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https://www.readbyqxmd.com/read/29677548/combination-of-curcumin-and-vagus-nerve-stimulation-attenuates-cerebral-ischemia-reperfusion-injury-induced-behavioral-deficits
#1
Jian Xu, Xinjuan Kong, Hong Xiu, Yihe Dou, Zeyu Wu, Peng Sun
AIM: Previous studies indicated that cerebral ischemia/reperfusion injury (CI/RI) could induce behavioral deficits. Single treatment of vagus nerve stimulation (VNS) or curcumin is reported to restore CI/RI-induced behavioral deficits. However, the synergic effect remains unclear. MATERIALS AND METHODS: Rats were divided into 6 groups: sham, CI/RI, VNS, CI/RI + VNS, VNS + curcumin and CI/RI + VNS + curcumin groups. Each group was further divided into three or four subgroups for further assessments...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29671021/protective-effect-of-vinpocetine-against-neurotoxicity-of-manganese-in-adult-male-rats
#2
Rania I Nadeem, Hebatalla I Ahmed, Bahia M El-Sayeh
Manganese (Mn) is required for many essential biological processes as well as in the development and functioning of the brain. Extensive accumulation of Mn in the brain may cause central nervous system dysfunction known as manganism, a motor disorder associated with cognitive and neuropsychiatric deficits similar to parkinsonism. Vinpocetine, a synthetic derivative of the alkaloid vincamine, is used to improve the cognitive function in cerebrovascular diseases. It possesses antioxidant and antiinflammatory properties...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29670520/two-behavioral-tests-allow-a-better-correlation-between-cognitive-function-and-expression-of-synaptic-proteins
#3
Marta Balietti, Giorgia Fattorini, Arianna Pugliese, Daniele Marcotulli, Luca Bragina, Fiorenzo Conti
The molecular substrate of age-associated cognitive decline (AACD) is still elusive. Evidence indicates that AACD is related to synaptic impairment in hippocampus, but different hippocampal regions play different roles, with the dorsal hippocampus (DH) associated to spatial learning, and the ventral hippocampus (VH) crucial for emotionality. If changes in hippocampal function contributes to AACD, this contribution may be reflected in alterations of synaptic protein levels. A commonly used approach to investigate this issue is western blotting...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29657693/the-effects-of-acceptance-and-commitment-therapy-on-man-smokers-comorbid-depression-and-anxiety-symptoms-and-smoking-cessation-a-randomized-controlled-trial
#4
Mohammadreza Davoudi, Abdollah Omidi, Mojtaba Sehat, Zahra Sepehrmanesh
Background: Besides physical problems, cigarette smoking is associated with a high prevalence of comorbid depression and anxiety symptoms. One of the reasons behind high post-cessation smoking lapse and relapse rates is inattentiveness to these symptoms during the process of cessation. The aim of this study was to examine the effects of acceptance and commitment therapy (ACT) on male smokers' comorbid depression and anxiety symptoms and smoking cessation. Methods: This two-group pre-test-post-test randomized controlled trial was done on a random sample of seventy male smokers...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29652298/-cognitive-processes-in-patients-with-different-structure-of-anxiety-disorders
#5
A A Chepelyuk, M G Vinogradova, T V Kovalenok, O A Dorofeeva, M V Metlina, G G Neznamov
AIM: To study the relationship between cognitive functions and psychopathological disturbances in anxiety disorders. MATERIAL AND METHODS: WAIS, the modified Witkin's Embedded figures test, a symptom scale (Yu.A. Aleksandrovsky et al. 1984) were administered to 111 patients, including 37 with generalized anxiety disorders (GAD, ICD-10 F41.1), 36 with anxiety-phobic disorders (AFD, ICD-10 F40) and 38 with anxiety-hypochondriac disorders (AHD, ICD-10 F45.2), and to 114 healthy people...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29608880/limitations-of-the-rat-medial-forebrain-lesion-model-to-study-prefrontal-cortex-mediated-cognitive-tasks-in-parkinson-s-disease
#6
Courtney Marshall, Kirsten M King, Sandhya Kortagere
Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive impairment (PD-MCI), which is comprised of deficits in executive function such as working memory, attention, cognitive flexibility, and spatial memory. The 6-hydroxydopamine (6-OHDA) induced unilateral medial forebrain bundle (MFB) lesion animal model successfully recapitulates PD motor impairment but is also used to assess non-motor deficits...
March 30, 2018: Brain Research
https://www.readbyqxmd.com/read/29599834/improvement-of-postoperative-cognitive-dysfunction-and-attention-network-function-of-patients-with-ischemic-cerebrovascular-disease-via-dexmedetomidine
#7
Jingchao Zhang, Guoliang Wang, Fangxiang Zhang, Qian Zhao
The protective effect of dexmedetomidine on cognitive dysfunction and decreased attention network function of patients with ischemic cerebrovascular disease after stenting was investigated. Fifty-eight patients with ischemic cerebrovascular disease undergoing stenting in Guizhou Provincial People's Hospital were selected and randomly divided into control group (n=29) and dexmedetomidine group (n=29). The dexmedetomidine group was treated with dexmedetomidine before induced anesthesia, while the control group was given the same dose of normal saline; and the normal volunteers of the same age were selected as the normal group (n=29)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29581965/involvement-of-cholinergic-dysfunction-and-oxidative-damage-in-the-effects-of-simulated-weightlessness-on-learning-and-memory-in-rats
#8
Yongliang Zhang, Qiong Wang, Hailong Chen, Xinmin Liu, Ke Lv, Tingmei Wang, Yanli Wang, Guohua Ji, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Qu
The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented. Cognitive function was assessed using the Morris water maze (MWM) and the shuttle box test. Additionally, parameters about cholinergic activity and oxidative stress were tested. Results showed that longer-than-14 d HU led to the inferior performances in the behavioral tasks...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29546728/ho-1-dependent-antioxidant-effects-of-ethyl-acetate-fraction-from-physalis-alkekengi-fruit-ameliorates-scopolamine-induced-cognitive-impairments
#9
Md Moniruzzaman, Young-Won Chin, Jungsook Cho
Physalis alkekengi var. francheti is an indigenous herb well known for its anti-inflammatory, sedative, antipyretic, and expectorant properties. However, the information regarding the impacts of P. alkekengi fruits (PAF) in modulation of oxidative stress and learning memory are still unknown. This study therefore evaluated the antioxidant properties of ethyl acetate (EA) fraction of PAF and its impacts on learning and memory. The antioxidant activities of PAF were evaluated in LPS-induced BV2 microglial cells...
March 15, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29514304/brain-connectivity-and-cognitive-flexibility-in-nonirradiated-adult-survivors-of-childhood-leukemia
#10
Thibo Billiet, Iris Elens, Charlotte Sleurs, Anne Uyttebroeck, Rudi D'Hooge, Jurgen Lemiere, Sabine Deprez
Background: This study aimed to assess functional and structural brain connectivity in adult childhood leukemia survivors and the link with cognitive functioning and previously identified risk factors such as intrathecal methotrexate dose and age at start of therapy. Methods: Thirty-one nonirradiated adult childhood leukemia survivors and 35 controls underwent cognitive testing and multimodal magnetic resonance imaging (resting state functional MRI, T1-weighted, diffusion-weighted, and myelin water imaging [MWI])...
March 5, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29501623/adenosine-a-2a-receptor-involves-in-neuroinflammation-mediated-cognitive-decline-through-activating-microglia-under-acute-hypobaric-hypoxia
#11
Peng-Zhi Chen, Wen-Juan He, Zhi-Ru Zhu, Guo-Ji E, Gang Xu, De-Wei Chen, Yu-Qi Gao
Hypobaric hypoxia (HH) at high altitudes leads to a wide range of cognitive impairments which can handicap human normal activities and performances. However, the underlying mechanism is still unclear. Adenosine A2A receptors (A2A Rs) of the brain are pivotal to synaptic plasticity and cognition. Besides, insult-induced up-regulation of A2A R regulates neuroinflammation and therefore induces brain damages in various neuropathological processes. The present study was designed to determine whether A2A R-mediate neuroinflammation involves in cognitive impairments under acute HH...
February 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29501577/correlations-between-csf-proteins-and-spontaneous-neuronal-activity-in-parkinson-s-disease
#12
Tao Guo, Xiaojun Guan, Qiaoling Zeng, Min Xuan, Quanquan Gu, Xiaojun Xu, Minming Zhang
The relationship between cerebrospinal fluid (CSF) proteins and brain function in Parkinson's disease (PD) is not explained clearly. We investigated the correlations between CSF proteins and spontaneous neuronal activity in PD patients via fractional amplitude of low-frequency fluctuation (fALFF) using the Parkinson's Progression Markers Initiative database. Twenty-eight PD patients underwent resting-state functional magnetic resonance imaging in "off" status and lumbar puncture within a month. Correlation analyses between CSF proteins and fALFF value in whole brain as well as clinical assessment scores were performed...
February 28, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29501411/social-cognition-differentiates-behavioral-variant-frontotemporal-dementia-from-other-neurodegenerative-diseases-and-psychiatric-disorders
#13
Flora Gossink, Sigfried Schouws, Welmoed Krudop, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols
OBJECTIVE: Although deficits in social cognition are established as core features in behavioral variant frontotemporal dementia (bvFTD), it remains unresolved if impaired social cognition distinguishes bvFTD from the broad differential diagnoses in clinical practice. Our aim was to study whether social cognition discriminates bvFTD from other neurodegenerative diseases and psychiatric disorders in patients presenting with late-onset frontal symptoms. Next, we studied the association of social cognition with frontal symptoms and cognitive functioning...
February 1, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29491716/psychiatric-and-physical-comorbidities-and-pain-in-patients-with-multiple-sclerosis
#14
Rogier Scherder, Neeltje Kant, Evelien T Wolf, Bas Pijnenburg, Erik Ja Scherder
Background: It has been observed that patients with multiple sclerosis (MS), who have psychiatric and physical comorbidities such as depression and COPD, have an increased risk of experiencing more pain. In this study, we have distinguished between pain intensity and pain affect, as the latter, particularly, requires treatment. Furthermore, while pain and comorbidities have been assessed using questionnaires, this is possibly a less reliable method for those who are cognitively vulnerable...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29490706/early-long-term-administration-of-the-csf1r-inhibitor-plx3397-ablates-microglia-and-reduces-accumulation-of-intraneuronal-amyloid-neuritic-plaque-deposition-and-pre-fibrillar-oligomers-in-5xfad-mouse-model-of-alzheimer-s-disease
#15
Justyna Sosna, Stephan Philipp, Ricardo Albay, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M LaFerla, Charles G Glabe
BACKGROUND: Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer's disease (AD). Microglia are believed to be key mediators of neuroinflammation during AD and responsible for the regulation of brain homeostasis by balancing neurotoxicity and neuroprotective events. We have previously reported evidence that neuritic plaques are derived from dead neurons that have accumulated intraneuronal amyloid and further recruit Iba1-positive cells, which play a role in either neuronal demise or neuritic plaque maturation or both...
March 1, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29486213/predication-of-different-stages-of-alzheimer-s-disease-using-neighborhood-component-analysis-and-ensemble-decision-tree
#16
Mingwu Jin, Weishu Deng
BACKGROUND: There is a spectrum of the progression from healthy control (HC) to mild cognitive impairment (MCI) without conversion to Alzheimer's disease (AD), to MCI with conversion to AD (cMCI), and to AD. This study aims to predict the different disease stages using brain structural information provided by MRI data. NEW METHOD: The neighborhood component analysis (NCA) is applied to select most powerful features for prediction. The ensemble decision tree classifier is built to predict which group the subject belongs to...
February 24, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29466775/novel-tacrine-hydroxyphenylbenzimidazole-hybrids-as-potential-multitarget-drug-candidates-for-alzheimer-s-disease
#17
Asha Hiremathad, Rangappa S Keri, A Raquel Esteves, Sandra M Cardoso, Sílvia Chaves, M Amélia Santos
Alzheimer's disease (AD) is a severe age-dependent neurodegenerative disorder affecting millions of people, with no cure so far. The current treatments only achieve some temporary amelioration of the cognition symptoms. The main characteristics of the patient brains include the accumulation of amyloid plaques and neurofibrillary tangles (outside and inside the neurons) but also cholinergic deficit, increased oxidative stress and dyshomeostasis of transition metal ions. Considering the multi-factorial nature of AD, we report herein the development of a novel series of potential multi-target directed drugs which, besides the capacity to recover the cholinergic neurons, can also target other AD hallmarks...
February 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29462665/cognitive-assessment-in-patients-with-multiple-sclerosis-from-neuropsychological-batteries-to-ecological-tools
#18
Aurélie Ruet, Bruno Brochet
BACKGROUND: Cognitive impairment (CI) is frequent in patients with multiple sclerosis (PwMS) and could negatively affect family social and vocational activities. Detecting CI is clinically relevant, so the emerging question is the strategy for assessing cognition in MS. OBJECTIVE: An update on cognitive assessment in PwMS with use of standard neuropsychological (NP) tests and ecological tools. RESULTS: The minimal cognitive assessment in MS should include at least NP tests assessing information processing speed (IPS) and verbal and visuospatial episodic memory...
February 17, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29357320/ginsenoside-rb1-protects-the-brain-from-damage-induced-by-epileptic-seizure-via-nrf2-are-signaling
#19
Yunbo Shi, Wang Miao, Junfang Teng, Lingli Zhang
BACKGROUND/AIMS: Ginsenoside Rb1 (Rb1) has been reported to have varieties of neuroprotective effects. This study aimed to evaluate the effects of Rb1 on pentylenetetrazol (PTZ)-induced rat brain injury and Mg2+ free-induced neuron injury and analyzed the detailed molecular mechanisms in vivo and in vitro. METHODS: Seizure duration and latency were measured in epilepsy kindled rat. The cognitive impairment was assessed by Morris water maze (MWM) test. Oxidative stress parameters, malondialdehyde (MDA) and glutathione (GSH) were measured by the 2-thiobarbituric acid methods and the DTNB-GSSG reductase recycling methods...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29339018/nicotine-alleviates-chronic-stress-induced-anxiety-and-depressive-like-behavior-and-hippocampal-neuropathology-via-regulating-autophagy-signaling
#20
Xi Xiao, Xueliang Shang, Baohui Zhai, Hui Zhang, Tao Zhang
Recently, we reported that chronic nicotine significantly improved chronic stress-induced impairments of cognition and the hippocampal synaptic plasticity in mice, however, the underlying mechanism still needs to be explored. In the present study, 32 male C57BL/6 mice were divided into four groups: control (CON), stress (CUS), stress with chronic nicotine administration (CUS + Nic) and chronic nicotine administration (Nic). The anxiety-like behavior and neuropathological alteration of DG neurons were examined...
March 2018: Neurochemistry International
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