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Tina Mallon, Annette Ernst, Christian Brettschneider, Hans-Helmut König, Tobias Luck, Susanne Röhr, Siegfried Weyerer, Jochen Werle, Edelgard Mösch, Dagmar Weeg, Angela Fuchs, Michael Pentzek, Luca Kleineidam, Kathrin Heser, Steffi Riedel-Heller, Wolfgang Maier, Birgitt Wiese, Martin Scherer
BACKGROUND: The prevalence of pain is very common in the oldest age group. Managing pain successfully is a key topic in primary care, especially within the ageing population. Different care settings might have an impact on the prevalence of pain and everyday life. METHODS: Participants from the German longitudinal cohort study on Needs, Health Service Use, Costs and Health-related Quality of Life in a large Sample of Oldest-old Primary Care Patients (85+) (AgeQualiDe) were asked to rate their severity of pain as well as the impairment with daily activities...
June 9, 2018: BMC Family Practice
Xudong Li, Kang Wang, Shuhong Jia, Zhi Zhou, Yi Jin, Xiangfei Zhang, Chunlei Hou, Wenjing Zheng, Pei Rong, Jinsong Jiao
BACKGROUND: Idiopathic rapid eye movement sleep behavior disorder (iRBD) likely represents the prodromal stage of synucleinopathy. The present study was to investigate if there was prospective memory (PM) impairment and the relationship between different PM tasks and traditional cognitive tests in patients with iRBD. METHODS: A total of 28 patients with iRBD, 25 with Parkinson's disease (PD) and 21 healthy controls were included. The Cambridge Prospective Memory Test (CAMPROMPT) was used to measure the PM including time-based (TBPM) and event-based PM (EBPM)...
July 2018: Sleep Medicine
Yue Hei, Rong Chen, Xicai Yi, Lizhou Wei, Qianfa Long, Weiping Liu
Permanent bilateral common carotid occlusion (2VO) is well-established to investigate the chronic cerebral hypoperfusion (CCH)-induced cognitive deficits. Besides, previous studies suggested that disturbance of Neuregulin1 (NRG1)/ErbB4 signaling is associated with cognitive impairments, as well as neuronal apoptosis and neuroinflammation in CNS. However, the expression pattern of hippocampal NRG1/ErbB4 has not been systematically investigated during CCH. Here, we aim to investigate the temporal changes of hippocampal NRG1/ErbB4 during CCH and their possible relationship with neuronal apoptosis and glial activation...
2018: Frontiers in Aging Neuroscience
Prasad Vijay Barre, Gadiraju Padmaja, Suvashisa Rana, Tiamongla
Background: Cancer pervades many dimensions of an individual's life - demanding a holistic treatment approach. However, studies with combined medical and psychological interventions (MPIs) are sparse. High-level stress and poor quality of life (QoL) can hinder patients' prognosis. The study thus aimed to analyze the impact of combined medical and psychological (psychoeducation, relaxation technique-guided imagery, and cognitive therapy) interventions on stress and QoL of cancer patients - head and neck, breast, and lung cancers...
May 2018: Indian Journal of Psychological Medicine
Lina Lu, Zongli Li, Yanhua Zuo, Libo Zhao, Bin Liu
OBJECTIVES: The use of X-ray for therapeutics always raises the problem of radiation hazards to living beings. In this research, we explored the radioprotective activity of glutathione (GSH) on cognitive ability of X-ray radiated tumor-bearing mice. METHODS: Forty C57BL/6 mice were chosen to establish the GL261 glioma model and randomly divided into four groups: Model group, X-ray group, Pre-GSH group and Pos-GSH group. Morris water maze test was used to test cognitive ability...
May 30, 2018: Neurological Research
Shisei Tei, Junya Fujino, Ryu-Ichiro Hashimoto, Takashi Itahashi, Haruhisa Ohta, Chieko Kanai, Manabu Kubota, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi
Inflexible behaviours in people with autism spectrum disorder (ASD) broadly obstruct social communication. Meanwhile, flexibility implicates cognitive control to resolve socially conflicting situations; however, it remains unclear how people with ASD behave in the face of these conflicts in this respect. We used the ultimatum game (UG) and the implicit-association test (IAT) to examine goal-directed/economic flexibility, both of which involve conflict and cognitive control. In addition, we used the Detail and Flexibility Questionnaire (DFlex) to measure inflexible everyday behaviour with diminished cognitive control and attention shifting...
May 24, 2018: Scientific Reports
Yue Hei, Rong Chen, Xicai Yi, Qianfa Long, Dakuan Gao, Weiping Liu
High mobility group box-1 (HMGB1) acts as a proinflammatory molecule once released into the extracellular space and inhibition of HMGB1 signaling has been reported be neuroprotective in neurodegenerative diseases. Besides, chronic cerebral hypoperfusion (CCH) causes cognitive impairment in neurodegenerative diseases. Here we tested the protective role of HMGB1 inhibition using anti-HMGB1 neutralizing antibody (Ab) against CCH in rats after bilateral common carotid artery occlusion (2VO). 169 male Sprague-Dawley rats underwent 2VO or sham operation...
May 16, 2018: Neuroscience
Wei Ouyang, Wenhui Wu, Zhiheng Fan, Jihui Wang, Huiju Pan, Weibin Yang
Fluid percussion (FP) injury model is a popular animal model of traumatic brain injury (TBI), but still there are some issues need to be addressed. To increase the validity and reliability of this technique, we adapted the FP device using electromagnetic protractor, stainless-steel cylinder, changing pressure transducer position, and foam pads to adjust the parameters of FP pulse. Besides, the adjusted FP device is more automatic. The FP pulse is promptly measured and displayed in a graphic user interface software...
May 18, 2018: Journal of Neuroscience Research
Shalini Sharma, Christoph Mueller, Robert Stewart, Nicola Veronese, Davy Vancampfort, Ai Koyanagi, Sarah E Lamb, Gayan Perera, Brendon Stubbs
OBJECTIVES: Investigate predictors of falls and fractures leading to hospitalization in a large cohort of people with dementia. DESIGN: A retrospective cohort study. SETTING AND PARTICIPANTS: People with diagnosed dementia between January 2007 and March 2013, aged >65 years, were assembled using data from the Maudsley Biomedical Research Centre Case Register, from 4 boroughs in London serving a population of 1.3 million people. MEASURES: Falls and/or fractures leading to hospitalization were ascertained from linked national records...
May 2, 2018: Journal of the American Medical Directors Association
Elena Pretegiani, Pietro Piu, Francesca Rosini, Pamela Federighi, Valeria Serchi, Gemma Tumminelli, Maria Teresa Dotti, Antonio Federico, Alessandra Rufa
Objective: Increasing evidence suggests a cerebellar contribution to modulate cognitive aspects of motor behavior and executive functions. Supporting findings come from studies on patients with neurodegenerative diseases, in which however, given the extent of the disease, the specific role of the cerebellum, could not be clearly isolated. Anti-saccades are considered a sensitive tool to test executive functions. The anti-saccade underlying neural network, consisting of different cortical areas and their downstream connections including the lateral cerebellum, has been largely clarified...
2018: Frontiers in Neurology
Jørgen Lous, Maj-Britt Glenn Lauritsen
OBJECTIVE: To search for predictive factors for language development measured by two receptive language tests for children, the Galker test (a word-recognition-in-noise test) testing hearing and vocabulary, and the Danish version of Reynell Developmental Language Scale (2nd revision, RDLS II) test, a language comprehension test. The study analysed if information about background variables and parents and pre-school teachers was predictive for test scores; if earlier middle ear disease, actual hearing loss and tympanometry was important for language development; and if the two receptive tests differed in terms of the degree to which variables were able to predict test scores at the age of three to five years...
June 2018: International Journal of Pediatric Otorhinolaryngology
Yuwei Zhang, Ge Wang, Lin Wang, Jian Zhao, Rui Huang, Qianying Xiong
OBJECTIVE: To study the effect of enriched environment (EE) on cognitive function and pathological changes in Alzheimer's disease (AD) mice. METHOD: 6-month-old of the male mice were divided into 3 groups (n = 8), the wild type C57BL/6 mice in the control group, the APP/PS1 transgenic mice of AD reared in either the standard environment or the EE. Mice were feeding for 8 weeks, and then moved into standard environment. The activity and cognitive function were measured by Open-field test and Morris-water Maze...
April 30, 2018: Human Vaccines & Immunotherapeutics
Eliana Vassena, Robin Gerrits, Jelle Demanet, Tom Verguts, Roma Siugzdaite
Preparing for a mentally demanding task calls upon cognitive and motivational resources. The underlying neural implementation of these mechanisms is receiving growing attention because of its implications for professional, social, and medical contexts. While several fMRI studies converge in assigning a crucial role to a cortico-subcortical network including Anterior Cigulate Cortex (ACC) and striatum, the involvement of Dorsolateral Prefrontal Cortex (DLPFC) during mental effort anticipation has yet to be replicated...
April 26, 2018: Neuropsychologia
Ping-Huang Tsai, Jian-Liang Liu, Ker-Neng Lin, Chiung-Chih Chang, Ming-Chyi Pai, Wen-Fu Wang, Jen-Ping Huang, Tzung-Jeng Hwang, Pei-Ning Wang
OBJECTIVES: To develop a simple dementia screening tool to assist primary care physicians in identifying patients with cognitive impairment among subjects with memory complaints or at a high risk for dementia. DESIGN: The Brain Health Test (BHT) was developed by several experienced neurologists, psychiatrists, and clinical psychologists in the Taiwan Dementia Society. Validation of the BHT was conducted in the memory clinics of various levels of hospitals in Taiwan...
2018: PloS One
Jian Xu, Xinjuan Kong, Hong Xiu, Yihe Dou, Zeyu Wu, Peng Sun
AIM: Previous studies indicated that cerebral ischemia/reperfusion injury (CI/RI) could induce behavioral deficits. Single treatment of vagus nerve stimulation (VNS) or curcumin is reported to restore CI/RI-induced behavioral deficits. However, the synergic effect remains unclear. MATERIALS AND METHODS: Rats were divided into 6 groups: sham, CI/RI, VNS, CI/RI + VNS, VNS + curcumin and CI/RI + VNS + curcumin groups. Each group was further divided into three or four subgroups for further assessments...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rania I Nadeem, Hebatalla I Ahmed, Bahia M El-Sayeh
Manganese (Mn) is required for many essential biological processes as well as in the development and functioning of the brain. Extensive accumulation of Mn in the brain may cause central nervous system dysfunction known as manganism, a motor disorder associated with cognitive and neuropsychiatric deficits similar to parkinsonism. Vinpocetine, a synthetic derivative of the alkaloid vincamine, is used to improve the cognitive function in cerebrovascular diseases. It possesses antioxidant and antiinflammatory properties...
July 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Marta Balietti, Giorgia Fattorini, Arianna Pugliese, Daniele Marcotulli, Luca Bragina, Fiorenzo Conti
The molecular substrate of age-associated cognitive decline (AACD) is still elusive. Evidence indicates that AACD is related to synaptic impairment in hippocampus, but different hippocampal regions play different roles, with the dorsal hippocampus (DH) associated to spatial learning, and the ventral hippocampus (VH) crucial for emotionality. If changes in hippocampal function contributes to AACD, this contribution may be reflected in alterations of synaptic protein levels. A commonly used approach to investigate this issue is western blotting...
2018: Frontiers in Aging Neuroscience
Mohammadreza Davoudi, Abdollah Omidi, Mojtaba Sehat, Zahra Sepehrmanesh
Background: Besides physical problems, cigarette smoking is associated with a high prevalence of comorbid depression and anxiety symptoms. One of the reasons behind high post-cessation smoking lapse and relapse rates is inattentiveness to these symptoms during the process of cessation. The aim of this study was to examine the effects of acceptance and commitment therapy (ACT) on male smokers' comorbid depression and anxiety symptoms and smoking cessation. Methods: This two-group pre-test-post-test randomized controlled trial was done on a random sample of seventy male smokers...
July 2017: Addiction & Health
A A Chepelyuk, M G Vinogradova, T V Kovalenok, O A Dorofeeva, M V Metlina, G G Neznamov
AIM: To study the relationship between cognitive functions and psychopathological disturbances in anxiety disorders. MATERIAL AND METHODS: WAIS, the modified Witkin's Embedded figures test, a symptom scale (Yu.A. Aleksandrovsky et al. 1984) were administered to 111 patients, including 37 with generalized anxiety disorders (GAD, ICD-10 F41.1), 36 with anxiety-phobic disorders (AFD, ICD-10 F40) and 38 with anxiety-hypochondriac disorders (AHD, ICD-10 F45.2), and to 114 healthy people...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Courtney A Marshall, Kirsten M King, Sandhya Kortagere
Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive impairment (PD-MCI), which is comprised of deficits in executive function such as working memory, attention, cognitive flexibility, and spatial memory. The 6-hydroxydopamine (6-OHDA) induced unilateral medial forebrain bundle (MFB) lesion animal model successfully recapitulates PD motor impairment but is also used to assess non-motor deficits...
March 30, 2018: Brain Research
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