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https://www.readbyqxmd.com/read/28260915/prevalence-of-mild-cognitive-impairment-in-employable-patients-after-acute-coronary-event-in-cardiac-rehabilitation
#1
Annett Salzwedel, Maria-Dorothea Heidler, Kathrin Haubold, Martin Schikora, Rona Reibis, Karl Wegscheider, Michael Jöbges, Heinz Völler
INTRODUCTION: Adequate cognitive function in patients is a prerequisite for successful implementation of patient education and lifestyle coping in comprehensive cardiac rehabilitation (CR) programs. Although the association between cardiovascular diseases and cognitive impairments (CIs) is well known, the prevalence particularly of mild CI in CR and the characteristics of affected patients have been insufficiently investigated so far. METHODS: In this prospective observational study, 496 patients (54...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28235543/protective-effects-of-linalool-against-amyloid-beta-induced-cognitive-deficits-and-damages-in-mice
#2
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Li Gao, Ming Yan, Silafu Aibai, Yanyan Yang, Xinmin Liu
AIM: Amyloid-beta (Aβ)-mediated neurotoxicity plays a pivotal role in the pathogenesis of Alzheimer's disease (AD), which induces oxidative stress and apoptosis. Linalool (LI) is a volatile monoterpene showing positive effect in AD treatment. This study was designed to research the protective effect of LI against neurotoxicity and cognitive deficits induced by Aβ1-40 in mice. MAIN METHODS: Aβ1-40 (4μg) solution was injected in the bilateral hippocampus to induce cognitive deficits of mice...
February 21, 2017: Life Sciences
https://www.readbyqxmd.com/read/28229380/cognitive-impairment-is-correlated-with-insulin-resistance-degree-the-pa-nico-study
#3
Antonietta Fava, Carmen Colica, Massimiliano Plastino, Demetrio Messina, Dario Cristiano, Carlo Opipari, Antonio Vaccaro, Gaetano Gorgone, Francesca Bosco, Alessandra Fratto, Matteo De Bartolo, Domenico Bosco
Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also evaluated whether a greater magnitude of cognitive decline could be related with their IR degree. We enrolled 335 diabetic patients and 142 non-diabetic subjects; participants were subdivided into three groups in accordance with their IRdegree assessed by Homa-Index (HI): Normal-HI (non-diabetic NHI < 2,6), Moderate-HI (MHI > 2,6 < 10) and High-HI (HHI > 10)...
February 23, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28133526/2-2-4-benzoylpiperazin-1-yl-ethyl-isoindoline-1-3-dione-derivatives-synthesis-docking-and-acetylcholinesterase-inhibitory-evaluation-as-anti-alzheimer-agents
#4
Ahmad Mohammadi-Farani, Nasibeh Abdi, Alireza Moradi, Alireza Aliabadi
OBJECTIVES: Alzheimer's disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of new donepezil like analogs. MATERIALS AND METHODS: A new series of phthalimide derivatives (compounds 4a-4j) were synthesized via Gabriel protocol and subsequently amidation reaction was performed using various benzoic acid derivatives...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28107681/enhancement-of-numeric-cognition-in-children-with-low-achievement-in-mathematic-after-a-non-instrumental-musical-training
#5
Fabiana Silva Ribeiro, Flávia H Santos
Studies suggest that musical training enhances spatial-temporal reasoning and leads to greater learning of mathematical concepts. The aim of this prospective study was to verify the efficacy of a Non-Instrumental Musical Training (NIMT) on the Numerical Cognition systems in children with low achievement in math. For this purpose, we examined, with a cluster analysis, whether children with low scores on Numerical Cognition would be grouped in the same cluster at pre and post-NIMT. Participants were primary school children divided into two groups according to their scores on an Arithmetic test...
March 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28070464/the-acceptability-of-tv-based-game-platforms-as-an-instrument-to-support-the-cognitive-evaluation-of-senior-adults-at-home
#6
Carlos Rivas Costa, Manuel José Fernández Iglesias, Luis Eulogio Anido Rifón, Miguel Gómez Carballa, Sonia Valladares Rodríguez
INTRODUCTION: The computing capabilities of state-of-the-art television sets and media centres may facilitate the introduction of computer-assisted evaluation at home. This approach would help to overcome the drawbacks of traditional pen-and-paper evaluations administered in clinical facilities, as they could be performed in a more comfortable environment, the subject's home, and they would be more flexible for designing complex environments for the evaluation of neuropsychological constructs that are difficult to assess through traditional testing...
2017: PeerJ
https://www.readbyqxmd.com/read/28025042/quercetin-ameliorates-chronic-unpredicted-stress-mediated-memory-dysfunction-in-male-swiss-albino-mice-by-attenuating-insulin-resistance-and-elevating-hippocampal-glut4-levels-independent-of-insulin-receptor-expression
#7
Vineet Mehta, Arun Parashar, Arun Sharma, Tiratha Raj Singh, Malairaman Udayabanu
Chronic stress is associated with impaired neuronal functioning, altered insulin signaling, and behavioral dysfunction. Quercetin has shown neuroprotective and antidiabetic effects, besides modulating cognition and insulin signaling. Therefore, in the present study, we explored whether or not quercetin ameliorates stress-mediated cognitive dysfunction and explored the underlying mechanism. Swiss albino male mice were subjected to an array of unpredicted stressors for 21days, during which 30mg/kg quercetin treatment was given orally...
December 23, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/28000907/-cognitive-reserve-scale-testing-the-theoretical-model-and-norms
#8
I Leon-Estrada, J Garcia-Garcia, L Roldan-Tapia
INTRODUCTION: The cognitive reserve theory may contribute to explain cognitive performance differences among individuals with similar cognitive decline and among healthy ones. However, more psychometric analysis are needed to guarantee the usage of tests for assessing cognitive reserve. AIMS: To study validity evidences in relation to the structure of the Cognitive Reserve Scale (CRS) and to create reference norms to interpret the scores. SUBJECTS AND METHODS: A total of 172 participants completed the scale and they were classified into two age groups: aged 36-64 years (n = 110) and 65-88 years (n = 62)...
January 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/27979475/ginsenoside-rg1-protects-against-sepsis-associated-encephalopathy-through-beclin-1-independent-autophagy-in-mice
#9
Yinjiao Li, Fang Wang, Yan Luo
BACKGROUND: Sepsis-associated encephalopathy (SAE), a commonly complicated syndrome, is associated with increased mortality in patients with sepsis. Currently, no specific diagnostic test or effective intervention exists to improve long-term consequences on cerebral function. Ginsenoside Rg1 (Rg1), a major component in ginseng, was reported to have pleiotropic properties including anti-inflammation and neuroprotection. The aim of our study was to investigate the protective effect of Rg1 on SAE and the potential mechanism...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27932195/sex-related-differences-in-attention-and-memory
#10
Rima Solianik, Marius Brazaitis, Albertas Skurvydas
BACKGROUND AND OBJECTIVES: The sex differences and similarities in cognitive abilities is a continuing topic of major interest. Besides, the influences of trends over time and possible effects of sex steroid and assessment time on cognition have expanded the necessity to re-evaluate differences between men and women. Therefore, the aim of this study was to compare cognitive performance between men and women in a strongly controlled experiment. MATERIALS AND METHODS: In total, 28 men and 25 women were investigated...
2016: Medicina
https://www.readbyqxmd.com/read/27928377/macular-thickness-in-subjective-memory-complaints-and-mild-cognitive-impairment-a-non-invasive-biomarker
#11
Domingo Giménez Castejón, Miriama Dudekova, Maria Gómez Gallego, Jerónimo Lajara Blesa
Alzheimer's disease (AD) is the main cause of dementia worldwide, which implies an important socioeconomic problem in developed countries. Efforts to find biomarkers to diagnose AD have been intensified, especially, to detect cognitive impairment in its early stages, also known as mild cognitive impairment (MCI). Besides, there are individuals referring memory loss that is unnoticeable in the family environment and presenting normal neuropsychological tests. The former patients are included in a clinical picture that has been recently called subjective memory complaints (SMC)...
February 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27881815/investigation-of-eligible-picture-categories-for-use-as-environmental-cues-in-dementia-sensitive-environments
#12
Tom Motzek, Kathrin Bueter, Gesine Marquardt
OBJECTIVES: Environmental cues, such as pictures, could be helpful in improving room-finding and wayfinding abilities among older patients. The aim of this study was to identify picture categories that are preferred and easily remembered by older patients and cognitively impaired patients and which therefore might be suitable for use as environmental cues in acute care settings. METHODS: Twelve pictures were presented to a sample of older patients (n = 37). The pictures represented different categories: familiarity (familiar vs...
November 22, 2016: HERD
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#13
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27828583/stress-and-cognitive-reserve-as-independent-factors-of-neuropsychological-performance-in-healthy-elderly
#14
João Carlos Centurion Cabral, Gessyka Wanglon Veleda, Martina Mazzoleni, Elton Pinto Colares, Lucas Neiva-Silva, Vera Torres das Neves
Exposure to high levels of cortisol and self-reported stress, as well as cognitive reserve, have been linked to Alzheimer's disease pathology. However, there are no studies on the interaction of these variables. The present study aims to assess the associations of measures of cortisol, self-reported stress, and cognitive reserve with neuropsychological performance in healthy elderly people; besides, to test the interactions between these variables. Cross-sectional analyzes were conducted using data on stress, cognitive reserve and clinical conditions in 145 healthy elderly adults...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27823981/repetitive-transcranial-magnetic-stimulation-improves-cognitive-function-of-alzheimer-s-disease-patients
#15
Junwu Zhao, Zhenguang Li, Yannan Cong, Jinbiao Zhang, Ming Tan, Haixia Zhang, Na Geng, Mengfan Li, Wenwen Yu, Peiyan Shan
Repetitive transcranial magnetic stimulation (rTMS) acts as a kind of widely-applied and non-invasive method in the intervention of some neurological disorders. This prospective, randomized, double-blind, placebo-controlled trial investigates the effect of rTMS on 30 cases of Alzheimer's disease (AD) participants, who were classified into mild and moderate groups. Neuropsychological tests were carried out using the AD Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and World Health Organization University of California-Los Angeles, Auditory Verbal Learning Test (WHO-UCLA AVLT) before, immediately after, and 6 weeks after the intervention...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27786581/the-effect-of-pre-eclampsia-like-syndrome-induced-by-l-name-on-learning-and-memory-and-hippocampal-glucocorticoid-receptor-expression-a-rat-model
#16
Hao Zhu, Weimin Zhu, Rong Hu, Huijun Wang, Duan Ma, Xiaotian Li
OBJECTIVE: We aimed to study the impacts of pre-eclampsia on the cognitive and learning capabilities of adolescent rat offspring and to explore the possible underlying mechanisms at the molecular level. METHODS: Pregnant rats were subcutaneously injected with saline solution (control) (n = 16) or NG-nitro-L-arginine methyl ester (L-NAME) (n = 16) from the 13th day of gestation until parturition. The brain tissues from fetal rats delivered by cesarean section were examined in both groups with hematoxylin and eosin (H&E) staining...
October 27, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27720868/the-use-of-the-emotional-object-recognition-as-an-assay-to-assess-learning-and-memory-associated-to-an-aversive-stimulus-in-rodents
#17
Anna Brancato, Gianluca Lavanco, Angela Cavallaro, Fulvio Plescia, Carla Cannizzaro
BACKGROUND: Emotionally salient experiences induce the formation of explicit memory traces, besides eliciting automatic or implicit emotional memory in rodents. This study aims at investigating the implementation of a novel task for studying the formation of limbic memory engrams as a result of the acquisition- and retrieval- of fear-conditioning - biased declarative memory traces, measured by animal discrimination of an "emotional-object". Moreover, by using this new method we investigated the potential interactions between stimulation of cannabinoid transmission and integration of emotional information and cognitive functioning...
December 1, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27711939/the-ege-agraphia-test-battery-for-identifying-the-writing-disorders-in-cases-with-mild-cognitive-impairment-and-alzheimer-s-disease
#18
Dilek Evyapan Akkuş, Ayşe Güler
OBJECTIVE: The purpose of this study is to create an agraphia test battery specific to Turkish language, to obtain normative data for the performance and error types of this test and to demonstrate its success in detecting cognitive disorders in mild cognitive impairment (MCI) cases that can't be diagnosed by formal neuropsychological tests due to the fact that writing is a complex function. METHOD: For this purpose, 20 healthy control (HC) subjects, 20 MCI cases and 20 Alzheimer's disease (AD) patients with Clinical Dementia Rating (CDR) of 1 were evaluated with Ege Agraphia Test Battery...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27701009/cannabis-and-its-effects-on-driving-skills
#19
REVIEW
Percy Bondallaz, Bernard Favrat, Haïthem Chtioui, Eleonora Fornari, Philippe Maeder, Christian Giroud
Traffic policies show growing concerns about driving under the influence of cannabis, since cannabinoids are one of the most frequently encountered psychoactive substances in the blood of drivers who are drug-impaired and/or involved in accidents, and in the context of a legalization of medical marijuana and of recreational use. The neurobiological mechanisms underlying the effects of cannabis on safe driving remain poorly understood. In order to better understand its acute and long-term effects on psychomotor functions involved in the short term ability and long-term fitness to drive, experimental research has been conducted based on laboratory, simulator or on-road studies, as well as on structural and functional brain imaging...
November 2016: Forensic Science International
https://www.readbyqxmd.com/read/27678482/scanning-the-world-in-three-seconds-mismatch-negativity-as-an-indicator-of-temporal-segmentation
#20
Lingyan Wang, Yan Bao, Jiyuan Zhang, Xiaoxiong Lin, Lang Yang, Ernst Pöppel, Bin Zhou
It has been shown recently that a temporal window of approximately 3 s has a modulatory effect on mismatch negativity (MMN). This special temporal window has been interpreted as representing the "subjective present," and reflecting a temporal segmentation in behavioral and cognitive functions. A more detailed look into the temporal structure of the MMN appeared to be reasonable as group data might shadow the underlying mechanisms because of too-high response variance. In this study, we tested one subject on 11 successive days at the same circadian phase using a passive auditory oddball paradigm with interstimulus intervals (ISIs) ranging from 1 s to 6 s...
September 2016: PsyCh Journal
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