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https://www.readbyqxmd.com/read/29780304/a-potential-compensatory-role-of-panx3-in-the-vno-of-a-panx1-knock-out-mouse-model
#1
Paige Whyte-Fagundes, Stefan Kurtenbach, Christiane Zoidl, Valery I Shestopalov, Peter L Carlen, Georg Zoidl
Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of Panx1 in sensory systems. Extending previous work from our group on primary olfaction, the expression patterns of Panxs in the vomeronasal organ (VNO), an auxiliary olfactory sense organ with a role in reproduction and social behavior, were compared. Using qRT-PCR and Immunohistochemistry (IHC), we confirmed the loss of Panx1, found similar Panx2 expression levels in both models, and a significant upregulation of Panx3 in mice with a global ablation of Panx1...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29778240/the-autonomic-neural-mechanism-of-right-ventricular-outflow-tract-tachycardia
#2
Hung-Yu Chang, Li-Wei Lo, Yu-Ruey Chen, Yu-Hui Chou, Wei-Lun Lin, Yenn-Jiang Lin, Wei-Hsian Yin, An-Ning Feng, Shih-Ann Chen
BACKGROUND: Ventricular tachycardia (VT) and ventricular premature complexes (VPCs) originating from the right ventricular outflow tract (RVOT) are generally considered as benign arrhythmias, with ECG morphology showing LBBB pattern and inferior axis. Pathogenic mechanisms in the genesis of RVOT VT/VPC remain largely unknown. We aimed to investigate the neural mechanism in RVOT ventricular arrhythmias in canine model. METHODS: Twelve mongrel dogs (13.7 ± 1...
July 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29772927/design-and-simulation-of-novel-laparoscopic-renal-denervation-system-a-feasibility-study
#3
Eunbi Ye, Jinhwan Baik, Seunghyun Lee, Seon Young Ryu, Sunchoel Yang, Eue-Keun Choi, Won Hoon Song, Hyeong Dong Yuk, Chang Wook Jeong, Sung-Min Park
PURPOSE: In this study, we propose a novel laparoscopy-based renal denervation (RDN) system for treating patients with resistant hypertension. In this feasibility study, we investigated whether our proposed surgical instrument can ablate renal nerves from outside of the renal artery safely and effectively and can overcome the depth-related limitations of the previous catheter-based system with less damage to the arterial walls. METHOD: We designed a looped bipolar electrosurgical instrument to be used with laparoscopy-based RDN system...
May 18, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29772321/use-of-polidocanol-endovenous-microfoam-to-improve-hemodynamics-and-symptomology-in-patients-with-challenging-clinical-presentations-a-case-series
#4
Paul E Davis, John Phillips, Raghu Kolluri
BACKGROUND: We performed a retrospective review of treatment effects with FDA-approved Polidocanol endovenous microfoam (PEM, Varithena® 1%) on venous symptomology in ten (N=10) C3-C6 patients with chronic venous insufficiency (CVI) and concomitant complex disease/pathology that limited the use of endothermal ablation (ETA). METHODS: Pathology included: risk of bruising or bleeding, severe lipodermatosclerosis (LDS), Hydradenitis Suppurativa, chronic fibrosis of the vein from prior superficial thrombosis, risk for nerve injury and failed prior ETA...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29765790/direct-posterior-bipolar-cervical-facet-radiofrequency-rhizotomy-a-simpler-and-safer-approach-to-denervate-the-facet-capsule
#5
Ovidiu Palea, Haroon M Andar, Ramon Lugo, Michelle Granville, Robert E Jacobson
Radiofrequency cervical rhizotomy has been shown to be effective for the relief of chronic neck pain, whether it be due to soft tissue injury, cervical spondylosis, or post-cervical spine surgery. The target and technique have traditionally been taught using an oblique approach to the anterior lateral capsule of the cervical facet joint. The goal is to position the electrode at the proximal location of the recurrent branch after it leaves the exiting nerve root and loops back to the cervical facet joint. The standard oblique approach to the recurrent nerve requires the testing of both motor and sensory components to verify the correct position and ensure safety so as to not damage the slightly more anterior nerve root...
March 14, 2018: Curēus
https://www.readbyqxmd.com/read/29760664/reduced-renal-mass-salt-sensitive-hypertension-is-resistant-to-renal-denervation
#6
Ionut Tudorancea, Thomas E Lohmeier, Barbara T Alexander, Dragos Pieptu, Dragomir N Serban, Radu Iliescu
Aim: Activation of the sympathetic nervous system is common in resistant hypertension (RHT) and also in chronic kidney disease (CKD), a prevalent condition among resistant hypertensives. However, renal nerve ablation lowers blood pressure (BP) only in some patients with RHT. The influence of loss of nephrons per se on the antihypertensive response to renal denervation (RDNx) is unclear and was the focus of this study. Methods: Systemic hemodynamics and sympathetically mediated low frequency oscillations of systolic BP were determined continuously from telemetrically acquired BP recordings in rats before and after surgical excision of ∼80% of renal mass and subsequent RDNx...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29750244/regulation-of-hepatic-lipid-accumulation-and-distribution-by-agouti-related-protein-in-male-mice
#7
Matthew T Maier, Anna Vilhelmsson, Sharon M Louie, Eirini Vagena, Daniel K Nomura, Suneil K Koliwad, Allison W Xu
Proper regulation of energy metabolism requires CNS neurons to respond dynamically to signals that reflect the body's energy reserve, and one such signal is leptin. Agouti-related protein (AgRP) is a hypothalamic neuropeptide that is markedly upregulated in leptin deficiency, a condition that is associated with severe obesity, diabetes and hepatic steatosis. Since deleting AgRP in mice does not alter energy balance, we sought to determine whether AgRP plays an indispensable role in regulating energy and hepatic lipid metabolism in the sensitized background of leptin deficiency...
May 9, 2018: Endocrinology
https://www.readbyqxmd.com/read/29737948/heat-stress-and-hepatic-laser-thermal-ablation-induce-hepatocellular-carcinoma-growth-role-of-pi3k-mtor-akt-signaling
#8
Danielle E Jondal, Scott M Thompson, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Rickey E Carter, Lewis R Roberts, Matthew R Callstrom, David A Woodrum
Purpose To determine if heat stress and hepatic laser thermal ablation induce hepatocellular carcinoma (HCC) growth and to identify growth factors induced by heat stress. Materials and Methods Non-heat-stressed HCC cells were cocultured with HCC cells or hepatocytes that were heat stressed at 37°C (physiologic), 45°C (moderate), or 50°C (severe) for 10 minutes and proliferation monitored with bioluminescence imaging for up to 6 days after heat stress (three experiments). Rats bearing orthotopic N1S1 HCC were randomly assigned to undergo immediate sham or laser thermal (3 W for 60 or 90 seconds; hereafter, 3W×60s and 3W×90s, respectively) ablation of the median (local) or left (distant) hepatic lobe, and tumor growth was monitored with magnetic resonance imaging for up to 18 days after ablation (six or more rats per group)...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29735654/identification-of-cytokine-specific-sensory-neural-signals-by-decoding-murine-vagus-nerve-activity
#9
Theodoros P Zanos, Harold A Silverman, Todd Levy, Tea Tsaava, Emily Battinelli, Peter W Lorraine, Jeffrey M Ashe, Sangeeta S Chavan, Kevin J Tracey, Chad E Bouton
The nervous system maintains physiological homeostasis through reflex pathways that modulate organ function. This process begins when changes in the internal milieu (e.g., blood pressure, temperature, or pH) activate visceral sensory neurons that transmit action potentials along the vagus nerve to the brainstem. IL-1β and TNF, inflammatory cytokines produced by immune cells during infection and injury, and other inflammatory mediators have been implicated in activating sensory action potentials in the vagus nerve...
May 22, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29732527/electrical-isolation-of-the-superior-vena-cava-by-laser-balloon-ablation-in-patients-with-atrial-fibrillation
#10
Martín R Arceluz, Pedro F Cruz, Estela Falconi, Rosa Montes de Oca, Reina Delgado, Jorge Figueroa, Marta Ortega, José L Merino
PURPOSE: The aim of the present study is to evaluate the feasibility and safety of SVC electrical isolation by LB ablation in patients with atrial fibrillation (AF) referred for pulmonary vein isolation (PVI). METHODS: Electrical disconnection of the SVC was attempted by LB in 13 consecutive patients (59 ± 10.5 years, 11 male) with AF following PVI. PVI was successfully achieved by standard LB in all before attempting SVC isolation. RESULTS: A laser beam was delivered with 6...
May 7, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29729780/mechanisms-of-and-adjuvants-for-bone-pain
#11
REVIEW
Nicholas Figura, Joshua Smith, Hsiang-Hsuan Michael Yu
Metastatic bone pain is a complex, poorly understood process. Understanding the unique mechanisms causing cancer-induced bone pain may lead to potential therapeutic targets. This article discusses the effects of osteoclast overstimulation within the tumor microenvironment; the role of inflammatory factors at the tumor-nociceptor interface; the development of structural instability, causing mechanical nerve damage; and, ultimately, the neuroplastic changes in the setting of sustained pain. Several adjuvant therapies are available to attenuate metastatic bone pain...
June 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29725383/therapeutic-effect-of-radiofrequency-ablation-on-children-with-supraventricular-tachycardia-and-the-risk-factors-for-postoperative-recurrence
#12
Chunli Li, Libo Jia, Zhenzhou Wang, Ling Niu, Xinjiang An
The present study investigated the therapeutic effect of radiofrequency ablation on children with supraventricular tachycardia (SVT), and explored the risk factors for postoperative recurrence. A total of 312 patients with pediatric SVT were selected in the Affiliated Children's Hospital of Xuzhou Medical University from April, 2011 to March, 2017. All the patients were subjected to radiofrequency ablation, and clinical data were retrospectively analyzed. Tilt table test was performed before and after treatment, and heart rate, systolic and diastolic blood pressure before and after treatment were compared...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29722913/the-tsc1-mtor-plk-axis-regulates-the-homeostatic-switch-from-schwann-cell-proliferation-to-myelination-in-a-stage-specific-manner
#13
Minqing Jiang, Rohit Rao, Jincheng Wang, Jiajia Wang, Lingli Xu, Lai Man Wu, Jonah R Chan, Huimin Wang, Q Richard Lu
Proper peripheral myelination depends upon the balance between Schwann cell proliferation and differentiation programs. The serine/threonine kinase mTOR integrates various environmental cues to serve as a central regulator of cell growth, metabolism, and function. We report here that tuberous sclerosis complex 1 (TSC1), a negative regulator of mTOR activity, establishes a stage-dependent program for Schwann cell lineage progression and myelination by controlling cell proliferation and myelin homeostasis. Tsc1 ablation in Schwann cell progenitors in mice resulted in activation of mTOR signaling, and caused over-proliferation of Schwann cells and blocked their differentiation, leading to hypomyelination...
May 3, 2018: Glia
https://www.readbyqxmd.com/read/29720816/short-lasting-unilateral-neuralgiform-headache-attacks
#14
REVIEW
Andrew Levy, Manjit S Matharu
Short-lasting unilateral neuralgiform headache attacks (SUNHA) is characterized by strictly unilateral trigeminal distribution pain that occurs in association with ipsilateral cranial autonomic features. There are two subtypes: short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). These disorders are rare but highly disabling. The management of SUNHA can be challenging...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720369/genomic-status-of-met-potentiates-sensitivity-to-met-and-mek-inhibition-in-nf1-related-malignant-peripheral-nerve-sheath-tumors
#15
Jacqueline D Peacock, Matthew G Pridgeon, Elizabeth A Tovar, Curt J Essenburg, Megan J Bowman, Zachary B Madaj, Julie Koeman, Elissa A Boguslawski, Jamie Grit, Rebecca D Dodd, Vadim Khachaturov, Diana M Cardona, Mark Chen, David G Kirsch, Flavio Maina, Rosanna Dono, Mary E Winn, Carrie R Graveel, Matthew R Steensma
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly resistant sarcomas that occur in up to 13% of individuals with Neurofibromatosis Type 1 (NF1). Genomic analysis of longitudinally collected tumor samples in a case of MPNST disease progression revealed early hemizygous microdeletions in NF1 and TP53, with progressive amplifications of MET, HGF, and EGFR. To examine the role of MET in MPNST progression, we developed mice with enhanced MET expression and Nf1 ablation (Nf1fl/KO;lox-stop-loxMETtg/+;Plp-creERTtg/+; referred to as NF1 MET)...
May 2, 2018: Cancer Research
https://www.readbyqxmd.com/read/29717380/selective-vs-global-renal-denervation-a-case-for-less-is-more
#16
REVIEW
Marat Fudim, Asher A Sobotka, Yue-Hui Yin, Joanne W Wang, Howard Levin, Murray Esler, Jie Wang, Paul A Sobotka
PURPOSE OF REVIEW: Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN. RECENT FINDINGS: Recent trials testing the efficacy of RDN showed mixed results. Initial investigations targeted global RDN as a therapeutic goal. The repeat observation of heterogeneous response to RDN including non-responders with lack of a BP reduction, or even more unsettling, BP elevations after RDN has raised concern for the detrimental effects of unselective global RDN...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29701371/surgical-treatment-of-complications-55-years-after-extraperiosteal-lucite-ball-plombage-for-pulmonary-tuberculosis
#17
Telma Calado, Magda Alvoeiro, Daniel Cabral, Mariana Antunes, Francisco Félix
INTRODUCTION: In the 1930-50s, before the introduction of antimicrobial drugs and development of techniques of pulmonary resssection, collapse therapy was the mainstream of treatment for cavitary pulmonary tuberculosis. The methods to achieve the collapse included artificial pneumothorax with air refills, phrenic nerve crush, thoracoplasty and extrapleural plombage. The plombage involves creating a cavity surgically under the ribs in the upper chest wall and filling the space with inert material, such fat, paraffin wax, rubber ballons, oil and methyl-methacrylate (Lucite) balls...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700056/ablation-of-the-ligament-of-marshall-and-left-stellate-ganglion-similarly-reduces-ventricular-arrhythmias-during-acute-myocardial-infarction
#18
Shan Liu, Xiaomei Yu, Da Luo, Zhiliang Qin, Xiaoying Wang, Wenbo He, Ruisong Ma, Huihui Hu, Jing Xie, Bo He, Zhibing Lu, Hong Jiang
BACKGROUND: Sympathetic denervation exerts protective effects against ventricular arrhythmias (VAs) induced by acute myocardial infarction. The results of a previous study indicated that the distal part of the ligament of Marshall (LOMLSPV ) might be a sympathetic conduit between the left stellate ganglion (LSG) and the ventricles. The present study was designed to compare the effects between LSG and LOMLSPV ablation on ischemia-induced VAs. METHODS: Twenty-nine dogs were randomly divided into sham ablation group (group 1, n=9), LOMLSPV ablation group (group 2, n=10), and LSG ablation group (group 3, n=10)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29692534/ultrasound-guided-peripheral-nerve-interventions-for-common-pain-disorders
#19
B P Krishna Prasad, Binu Joy, Vijayakumar A Raghavendra, Ajith Toms, Danny George, Brijesh Ray
There are a number of common pain disorders that can be managed effectively by injections around or ablation of peripheral nerves. Ultrasound is a universally available imaging tool, is safe, cost-effective, and is excellent in imaging many peripheral nerves and guiding needles to the site of the nerves. This article aims to present an overview of indications and techniques of such procedures that can be effectively performed by a radiologist.
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29691410/control-of-mechanical-pain-hypersensitivity-in-mice-through-ligand-targeted-photoablation-of-trkb-positive-sensory-neurons
#20
Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G Lechner, Paul A Heppenstall
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optogenetic activation of these neurons after nerve injury evokes marked nociceptive behavior...
April 24, 2018: Nature Communications
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