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https://www.readbyqxmd.com/read/29677689/neural-and-behavioral-changes-after-the-use-of-hearing-aids
#1
Hanin Karawani, Kimberly A Jenkins, Samira Anderson
OBJECTIVE: Individuals with age-related hearing loss (ARHL) can restore some loss of the auditory function with the use of hearing aids (HAs). However, what remains unknown are the physiological mechanisms that underlie how the brain changes with exposure to amplified sounds though the use of HAs. We aimed to examine behavioral and physiological changes induced by HAs. METHODS: Thirty-five older-adults with moderate ARHL with no history of hearing aid use were fit with HAs tested in aided and unaided conditions, and divided into experimental and control groups...
April 7, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29677619/associations-of-early-childhood-adversities-with-mental-disorders-psychological-functioning-and-suitability-for-psychotherapy-in-adulthood
#2
Erkki Heinonen, Paul Knekt, Tommi Härkänen, Esa Virtala, Olavi Lindfors
Childhood adversities frequently precede adulthood depression and anxiety. Yet, how they impact needed treatment duration, type or focus in these common disorders, is unclear. For developing more individualized and precise interventions, we investigated whether specific early adversities associate with patients' distinct psychiatric problems, psychological vulnerabilities, and suitability for psychotherapy. A total of 221 depressed and anxious adult outpatients (excluding psychotic, severe personality, bipolar, and substance abuse disorders) referred from community, student, occupational, and private healthcare services filled the Childhood Family Atmosphere Questionnaire (CFAQ)...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677578/tobacco-outlet-density-and-tobacco-knowledge-beliefs-purchasing-behaviours-and-price-among-adolescents-in-scotland
#3
Helena Tunstall, Niamh K Shortt, Claire L Niedzwiedz, Elizabeth A Richardson, Richard J Mitchell, Jamie R Pearce
Despite long-term falls in global adult smoking prevalence and over 50 years of tobacco control policies, adolescent smoking persists. Research suggests greater densities of tobacco retail outlets in residential neighbourhoods are associated with higher adolescent smoking rates. Policies to reduce retail outlets have therefore been identified by public health researchers as a potential 'new frontier' in tobacco control. Better understanding of the pathways linking density of tobacco retailers and smoking behaviour could support these policies...
February 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29677572/temperament-and-character-profiles-are-associated-with-depression-outcome-in-psychiatric-secondary-care-patients-with-harmful-drinking
#4
Vesa Paavonen, Kaisa Luoto, Antero Lassila, Esa Leinonen, Olli Kampman
BACKGROUND: Temperament and character profiles have been associated with depression outcome and alcohol abuse comorbidity in depressed patients. How harmful alcohol use modifies the effects of temperament and character on depression outcome is not well known. Knowledge of these associations could provide a method for enhancing more individualized treatment strategies for these patients. METHODS: We screened 242 depressed patients with at least moderate level of depressive symptoms...
April 7, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29677398/does-stress-increase-risk-of-breast-cancer-a-15-year-prospective-study
#5
Phyllis Butow, Melanie Price, Joseph Coll, Katherine Tucker, Bettina Meiser, Roger Milne, Judith Wilson, Louise Heiniger, Brandi Baylock, Tracey Bullen, Prue Weideman, Kelly-Anne Phillips
OBJECTIVE: The possible impact of stress on cancer incidence remains controversial. We prospectively evaluated associations between life event stressors, social support, personality characteristics (optimism, anger control, anti-emotionality) and risk of developing primary breast cancer (BCa), in women at increased familial risk of BCa. METHODS: A prospective cohort, repeated measures design was employed. Recruitment was through the Kathleen Cuningham Foundation Consortium for Research into Familial breast cancer (kConFab), which collects genetic, epidemiological and clinical data from Australasian families with multiple BCa cases...
April 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29677205/anemia-in-tuberculosis-cases-and-household-controls-from-tanzania-contribution-of-disease-coinfections-and-the-role-of-hepcidin
#6
Jerry Hella, Colin I Cercamondi, Francis Mhimbira, Mohamed Sasamalo, Nicole Stoffel, Marcel Zwahlen, Thomas Bodmer, Sebastien Gagneux, Klaus Reither, Michael B Zimmermann, Lorenz Risch, Lukas Fenner
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat outcomes. We studied the contribution of anemia and the role of the iron regulatory hormone hepcidin among TB patients and household contacts. METHODS: We analyzed serum samples from 102 TB cases and 98 controls without TB, matched by age/sex, for hepcidin, iron, and inflammation parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29677197/a-novel-statistical-method-for-assessing-effective-adherence-to-medication-and-calculating-optimal-drug-dosages
#7
Garrett Greene, Richard W Costello, Breda Cushen, Imran Sulaiman, Elaine Mac Hale, Ronan M Conroy, Frank Doyle
OBJECTIVE: We derive a novel model-based metric for effective adherence to medication, and validate it using data from the INhaler Compliance Assessment device (INCATM). This technique employs dose timing data to estimate the threshold drug concentration needed to maintain optimal health. METHODS: The parameters of the model are optimised against patient outcome data using maximum likelihood methods. The model is fitted and validated by secondary analysis of two independent datasets from two remote-monitoring studies of adherence, conducted through clinical research centres of 5 Irish hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29677189/progress-in-the-pharmacological-treatment-of-human-cystic-and-alveolar-echinococcosis-compounds-and-therapeutic-targets
#8
Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29677170/development-of-the-who-environmental-noise-guidelines-for-the-european-region-an-introduction
#9
Dorota Jarosińska, Marie-Ève Héroux, Poonum Wilkhu, James Creswick, Jos Verbeek, Jördis Wothge, Elizabet Paunović
Following the Parma Declaration on Environment and Health adopted at the Fifth Ministerial Conference (2010), the Ministers and representatives of Member States in the WHO European Region requested the World Health Organization (WHO) to develop updated guidelines on environmental noise, and called upon all stakeholders to reduce children's exposure to noise, including that from personal electronic devices. The WHO Environmental Noise Guidelines for the European Region will provide evidence-based policy guidance to Member States on protecting human health from noise originating from transportation (road traffic, railway and aircraft), wind turbine noise, and leisure noise in settings where people spend the majority of their time...
April 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29677086/hematologic-adverse-events-associated-with-prolonged-valganciclovir-treatment-in-congenital-cytomegalovirus-infection
#10
Liron Ziv, Joanne Yacobovich, Joseph Pardo, Havatzelet Yarden-Bilavsky, Jacob Amir, Micky Osovsky, Efraim Bilavsky
BACKGROUND: Valganciclovir (2/d) therapy for 6 months in neonates with symptomatic congenital cytomegalovirus infection improves hearing and neurodevelopmental outcome. The only reported adverse event was neutropenia. Since 2009, our protocol for symptomatic congenital cytomegalovirus infection was a 1-year treatment of 2/d for the first 3 months followed by 9 months of 1/d. METHODS: A retrospective study. Infants with congenital cytomegalovirus treated with valganciclovir for 1 year were recruited...
April 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29677068/health-care-costs-for-the-evaluation-surgery-and-follow-up-care-of-living-kidney-donors
#11
Steven Habbous, Sisira Sarma, Lianne Barnieh, Eric McArthur, Scott Klarenbach, Braden Manns, Mehmet A Begen, Krista L Lentine, Amit X Garg
BACKGROUND: The health care costs to evaluate, perform surgery, and follow a living kidney donor for the year after donation are poorly described. METHODS: We obtained information on the health care costs of 1099 living kidney donors between April 1, 2004 and March 31, 2014 from Ontario, Canada using comprehensive health care administrative databases. We estimated the cost of 3 periods of the living donation process: the predonation evaluation period (start of evaluation until the day before donation), perioperative period (day of donation until 30-days postdonation), and 1 year of follow-up period (after perioperative period until 1-year postdonation)...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677062/opioid-oversupply-after-joint-and-spine-surgery-a-prospective-cohort-study
#12
Mark C Bicket, Elizabeth White, Peter J Pronovost, Christopher L Wu, Myron Yaster, G Caleb Alexander
BACKGROUND: Many patients receive prescription opioids at hospital discharge after surgery, yet little is known regarding how often these opioids go unused. We estimated the prevalence of unused opioids, use of nonopioid analgesics, and storage and disposal practices after same-day and inpatient surgery. METHODS: In this prospective cohort study at a large, inner-city tertiary care hospital, we recruited individuals ≥18 years of age undergoing elective same-day or inpatient joint and spine surgery from August to November 2016...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29677057/newborn-resuscitation-skills-in-health-care-providers-at-a-zambian-tertiary-center-and-comparison-to-world-health-organization-standards
#13
Sara C Mistry, Richard Lin, Hazel Mumphansha, Laura C Kettley, Janaki A Pearson, Sonia Akrimi, David J Mayne, Wonder Hangoma, M Dylan Bould
BACKGROUND: Birth asphyxia is a leading cause of early neonatal death. In 2013, 32% of neonatal deaths in Zambia were attributable to birth asphyxia and trauma. Basic, timely interventions are key to improving outcomes. However, data from the World Health Organization suggest that resuscitation is often not initiated, or is conducted suboptimally. Currently, there are little data on the quality of newborn resuscitation in the context of a tertiary center in a lower-middle income country...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29677050/changes-in-albuminuria-and-renal-outcome-in-patients-with-type-2-diabetes-and-hypertension-a-real-life-observational-study
#14
Francesca Viazzi, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Eulalia Greco, Salvatore De Cosmo, Roberto Pontremoli
OBJECTIVES: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29677038/postoperative-b-type-natriuretic-peptide-as-predictor-for-postoperative-outcomes-in-patients-implanted-with-left-ventricular-assist-devices
#15
Gardner Yost, Geetha Bhat, Patroklos Pappas, Antone Tatooles
Brain natriuretic peptide (BNP) is a cardiac neurohormone known to correlate with left ventricular (LV) dilation, decreased contractility, and increased stiffness. Consequently, BNP has been used as a prognostic tool to assess the degree of LV unloading for patients supported by continuous-flow LV assist devices (LVADs). We assessed the prognostic value of changes in BNP in the 2 weeks after LVAD implantation. This retrospective study analyzed laboratory findings and outcomes of 189 LVAD patients. Patients were separated into two groups based on whether serum BNP levels had improved from preoperative levels by postoperative day 14...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29676975/eighteen-month-clinical-study-of-universal-adhesives-in-noncarious-cervical-lesions
#16
V C Ruschel, S Shibata, S C Stolf, Y Chung, L N Baratieri, H O Heymann, R Walter
OBJECTIVE: To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs). METHODS AND MATERIALS: This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29676936/pediatric-metabolic-outcome-comparisons-based-on-a-spectrum-of-obesity-and-asthmatic-symptoms
#17
Ashley D Perdue, Lesley A Cottrell, Christa L Lilly, William A Gower, Brian A Ely, Brad Foringer, Melvin L Wright, William A Neal
RATIONALE: Asthma and obesity are two of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk...
April 20, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29676861/spatial-processes-decouple-management-from-objectives-in-a-heterogeneous-landscape-predator-control-as-a-case-study
#18
Peter J Mahoney, Julie K Young, Kent R Hersey, Randy T Larsen, Brock R McMillan, David C Stoner
Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model...
April 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29676824/the-safety-effectiveness-and-cost-effectiveness-of-cytisine-in-achieving-six-month-continuous-smoking-abstinence-in-tuberculosis-patients-protocol-for-a-double-blind-placebo-controlled-randomised-trial
#19
Omara Dogar, Deepa Barua, Melanie Boeckmann, Helen Elsey, Razia Fatima, Rhian Gabe, Rumana Huque, Ada Keding, Amina Khan, Daniel Kotz, Eva Kralikova, James N Newell, Iveta Nohavova, Steve Parrott, Anne Readshaw, Lottie Renwick, Aziz Sheikh, Kamran Siddiqi
BACKGROUND AND AIMS: Tuberculosis (TB) patients who quit smoking have much better disease outcomes than those who continue to smoke. Behavioural support combined with pharmacotherapy is the most effective strategy in helping people to quit, in general populations. However, there is no evidence for the effectiveness of this strategy in TB patients who smoke. We will assess the safety, effectiveness and cost-effectiveness of cytisine - a low-cost plant-derived nicotine substitute - for smoking cessation in TB patients compared with placebo, over and above brief behavioural support...
April 20, 2018: Addiction
https://www.readbyqxmd.com/read/29676755/drinking-water-disinfection-by-products-exposure-and-health-effects-on-pregnancy-outcomes-a-systematic-review
#20
Funanani Mashau, Esper Jacobeth Ncube, Kuku Voyi
Epidemiological studies have found that maternal exposure to disinfection by-products (DBPs) may lead to adverse pregnancy outcomes although the findings tend to be inconsistent. The objective of this study was to systematically review the evidence in associated with drinking water DBP exposure in relation to adverse pregnancy outcomes. Peer-reviewed articles were identified using electronic databases searched for studies published in the English language. Studies selected for review were evaluated for exposure assessment, confounders, and analyses risks of bias in the selection, outcomes assessment, and attrition...
April 2018: Journal of Water and Health
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