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https://www.readbyqxmd.com/read/29925084/evaluation-of-stop-smoking-in-its-tracks-an-intensive-smoking-cessation-program-for-pregnant-aboriginal-women-incorporating-contingency-based-financial-rewards
#1
Megan E Passey, Janelle M Stirling
BACKGROUND: Smoking during pregnancy is three times as common among Aboriginal women as non-Aboriginal women, with consequent higher rates of adverse health outcomes. Effective interventions to support Aboriginal women to quit smoking have not yet been identified. OBJECTIVES: To assess the feasibility and acceptability of implementing a culturally tailored, intensive smoking cessation program, including contingency-based financial rewards (CBFR), for pregnant Aboriginal women...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925065/impact-of-laparoscopic-repair-of-large-hiatus-hernia-on-quality-of-life-observational-cohort-study
#2
Stefano Siboni, Emanuele Asti, Pamela Milito, Gianluca Bonitta, Andrea Sironi, Alberto Aiolfi, Luigi Bonavina
BACKGROUND: Laparoscopic surgery has proven safe and effective in the treatment of large hiatus hernia. Differences may exist between objectively assessed surgical outcomes, symptomatic scores, and patient-reported outcomes. METHODS: An observational, single-arm cohort study was conducted in patients undergoing primary laparoscopic repair with crura mesh augmentation and Toupet fundoplication for large (> 50% of intrathoracic stomach) type III-IV hiatus hernia...
June 20, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29925044/a-systematic-review-of-patient-reported-outcomes-in-phase-ii-or-iii-clinical-trials-of-myelodysplastic-syndromes-and-acute-myeloid-leukemia
#3
REVIEW
Ashley Leak Bryant, Sarah W Drier, Sejin Lee, Antonia V Bennett
The purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) instruments, and to summarize the symptom and other health related quality of life (HRQOL) concepts most frequently assessed and the PRO instruments that were used. Sixteen manuscripts describing 14 distinct trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published between 1996-2017. In trials evaluating anemia, PRO scores showed significant improvement in relevant domains (e...
June 7, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29925037/tspo-ligand-pk11195-improves-alzheimer-related-outcomes-in-aged-female-3xtg-ad-mice
#4
Amy Christensen, Christian J Pike
Alzheimer's disease (AD) pathogenesis is a multifactorial process that involves numerous pathways within the central nervous system. Thus, interventions that interact with several disease-related pathways may offer an increased opportunity for successful prevention and treatment of AD. Translocator protein 18 kD (TSPO) is a mitochondrial protein that is associated with regulation of many cellular processes including inflammation, steroid synthesis, apoptosis, and mitochondrial respiration. Although TSPO ligands have been shown to be protective in several neurodegenerative paradigms, little work has been done to assess their potential as treatments for AD...
June 17, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29924893/reliability-of-heartsmap-as-a-tool-for-evaluating-psychosocial-assessment-documentation-practices-in-emergency-departments-for-pediatric-mental-health-complaints
#5
Carson Gill, Brendan Arnold, Sean Nugent, Alykhan Rajwani, Michael Xu, Tyler Black, Quynh Doan
OBJECTIVES: The goal of this study was to assess the reliability of HEARTSMAP as a standardized tool for evaluating the quality of psychosocial assessment documentation of pediatric mental health presentations to the emergency department. In addition, we report on current documentation practices. METHODS: We conducted a retrospective cross-sectional study of pediatric (up to age 17) mental health-related visits to four emergency departments between April 1, 2013 and March 31, 2014...
June 20, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29924866/a-mobile-clinic-approach-to-the-delivery-of-community-based-mental-health-services-in-rural-haiti
#6
J Reginald Fils-Aimé, David J Grelotti, Tatiana Thérosmé, Bonnie N Kaiser, Giuseppe Raviola, Yoldie Alcindor, Jennifer Severe, Emmeline Affricot, Katherine Boyd, Rupinder Legha, Shin Daimyo, Stephanie Engel, Eddy Eustache
This study evaluates the use of a mental health mobile clinic to overcome two major challenges to the provision of mental healthcare in resource-limited settings: the shortage of trained specialists; and the need to improve access to safe, effective, and culturally sound care in community settings. Employing task-shifting and supervision, mental healthcare was largely delivered by trained, non-specialist health workers instead of specialists. A retrospective chart review of 318 unduplicated patients assessed and treated during the mobile clinic's first two years (January 2012 to November 2013) was conducted to explore outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29924786/-risk-factors-for-the-development-of-life-threatening-ventricular-arrhythmias-following-surgical-reconstruction-of-the-left-ventricle
#7
E V Rosseĭkin, E E Kobzev, O V Popyl'kova, S S Durmanov, V V Bazylev
Death in patients with postinfarction aneurysms of the left ventricle (LV) is mainly caused by life-threatening ventricular arrhythmias - ventricular tachycardias (VTs) and ventricular fibrillations (VFs). Surgical reconstruction of the LV may potentially lead to disruption of the re-entry mechanism, lying at the basis of ventricular tachyarrhythmias. A series of authors demonstrated high efficacy of such procedures as endocardectomy and radiofrequency ablation of the borderline zone of the LV. But high incidence of relapses, difficulty detecting the localization of VT and performing radiofrequency ablation (RFA), as well as high incidence of spontaneous and induced VTs in patients with postinfarction aneurysms of the LV have preserved dissatisfaction with the currently existing techniques...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924772/-biological-aspects-and-clinical-application-of-bone-marrow-stem-cells-in-critical-lower-limb-ischaemia
#8
P Iu Orekhov, A V Troitskiĭ, A V Chupin
Critical lower-limb ischaemia (CLLI) is associated with high risk of limb loss and a lethal outcome, as well as with decreased quality of life. The underlying cause of the disease is imbalance between blood supply of ischaemized tissues and their metabolic demands. Restoration of adequate perfusion with the help of standard medicamentous therapy or operative treatment is often inefficient or impossible. Cell therapy (CT) is a novel strategy making it possible to stimulate the growth of the microvascular bed and the mechanisms of molecular-cellular repair...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924737/outcomes-in-oligohydramnios-the-role-of-etiology-in-predicting-pulmonary-morbidity-mortality
#9
Ashley Hesson, Elizabeth Langen
OBJECTIVE: Early-onset oligohydramnios is typically secondary to renal-urinary anomalies (RUA) or preterm premature rupture of membranes (PPROM). We compared neonatal pulmonary outcomes between these etiologies. METHODS: We conducted a retrospective cohort study of women with oligohydramnios identified before 24 completed weeks of gestation attributed to either PPROM or RUA. Patients were excluded if other fetal anomalies were noted. Respiratory morbidity was assessed by the need for oxygen at 36 corrected weeks or at hospital discharge...
June 20, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29924719/functional-and-patient-reported-outcomes-improve-over-the-course-of-rehabilitation-a-secondary-analysis-of-the-acl-sports-trial
#10
Amelia J H Arundale, Jacob J Capin, Ryan Zarzycki, Angela Smith, Lynn Snyder-Mackler
BACKGROUND: The Anterior Cruciate Ligament-Specialized Post-Operative Return to Sports (ACL-SPORTS) randomized controlled trial was designed to address deficits in functional and patient-reported outcomes. The trial examined the effects of a secondary ACL prevention program that included progressive strengthening, agility training, plyometrics (SAP), and other components of current primary prevention protocols, with perturbation training (SAP + PERT group) and without PERT (SAP group)...
June 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29924684/whatsapp-a-real-time-tool-to-reduce-the-knowledge-gap-and-share-the-best-clinical-practices-in-psoriasis
#11
Luis D Mazzuoccolo, Maria Noel Esposito, Paula C Luna, Sharon Seiref, Mirtha Dominguez, Cristina M Echeverria
BACKGROUND: Psoriasis is a chronic inflammatory disease that affects around 100 million people worldwide. The burden of disease is high, but more recent therapies show promising results. Clinicians need, however, more training in the use of such therapies. INTRODUCTION: Project ECHO® (Extension for Community Healthcare Outcomes) is structured around the promise of delivering medical education at a distance, empowering clinicians who operate in remote areas. The use of instant messaging services, such as WhatsApp® Messenger, has the potential to improve on the existing framework and bridge the existing gap of knowledge...
June 20, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29924633/an-intra-articular-steroid-injection-at-6-weeks-postoperatively-for-shoulder-stiffness-after-arthroscopic-rotator-cuff-repair-does-not-affect-repair-integrity
#12
In-Bo Kim, Dong Wook Jung
BACKGROUND: Shoulder stiffness is a common complication after arthroscopic rotator cuff repair. However, there is no consensus on the treatment of stiffness after repair. Although one treatment option is an intra-articular steroid injection, it may negatively affect repair integrity, and there is a paucity of literature regarding the timing of intra-articular injections for stiffness after repair and its effect on repair integrity. PURPOSE: To compare repair integrity and clinical outcomes after an intra-articular steroid injection administered at 6 weeks and 12 weeks postoperatively for shoulder stiffness after arthroscopic rotator cuff repair...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29924498/microwave-ablation-with-continued-egfr-tyrosine-kinase-inhibitor-therapy-prolongs-disease-control-in-non-small-cell-lung-cancers-with-acquired-resistance-to-egfr-tyrosine-kinase-inhibitors
#13
Xin Li, Han Qi, Gou Qing, Ze Song, Lin Xie, Fei Cao, Xiaoming Chen, Weijun Fan
BACKGROUND: Although patients with EGFR-mutant non-small-cell lung cancer (NSCLC) benefit from treatment with EGFR-tyrosine kinase inhibitors (TKIs), outcomes are limited by the eventual development of acquired resistance. We conducted a retrospective study to evaluate the efficacy and feasibility of EGFR-TKI therapy beyond focal progression, associated with microwave ablation. METHODS: Patients with metastatic EGFR-mutant NSCLC treated with EGFR-TKIs at our institutions from May 2012 to December 2017 were identified...
June 20, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29924481/mental-versus-physical-fatigue-after-subarachnoid-hemorrhage-differential-associations-with-outcome
#14
Anne M Buunk, Rob J M Groen, Rianne A Wijbenga, Aaltje L Ziengs, Jan D M Metzemaekers, J Marc C van Dijk, Jacoba M Spikman
BACKGROUND: Fatigue is a major consequence of subarachnoid hemorrhage (SAH), but the specific characteristics are unclear. Our objective was to investigate the nature of post-SAH fatigue (mental or physical) and to determine the relationship with functional outcome in the chronic stage. Also, the possible influence of mood disorders and acute SAH-related factors (SAH type and external cerebrospinal fluid (CSF) drainage) on the presence of fatigue was investigated. METHODS: Patients with an aneurysmal SAH (aSAH) or angiographically negative SAH (anSAH) were assessed 3 to 10 years post-SAH (N = 221)...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924460/cc002-unc-females-are-mouse-models-of-exercise-induced-paradoxical-fat-response
#15
Rachel C McMullan, Martin T Ferris, Timothy A Bell, Vineet D Menachery, Ralph S Baric, Kunjie Hua, Daniel Pomp, Abbie E Smith-Ryan, Fernando Pardo-Manuel de Villena
Exercise results in beneficial health outcomes and protects against a variety of chronic diseases. However, U.S. exercise guidelines recommend identical exercise programs for everyone, despite individual variation in responses to these programs, including paradoxical fat gain. Experimental models of exercise-induced paradoxical outcomes may enable the dissection of underlying physiological mechanisms as well as the evaluation of potential interventions. Whereas several studies have identified individual mice exhibiting paradoxical fat gain following exercise, no systematic effort has been conducted to identify and characterize models of paradoxical response...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29924456/hereditary-amyloidosis-related-to-transthyretin-v30m-hattr-v30m-disease-progression-in-treated-and-untreated-patients
#16
Isabel Conceição, Bruno Miranda, José Castro, Mamede de Carvalho
BACKGROUND: Hereditary amyloidosis related to transthyretin V30M (hATTR V30M) is a progressive length-dependent sensory-motor axonal neuropathy. Here, we aim to compare the disease progression of treated (liver transplant or tafamidis) versus untreated patients with hATTR V30M. METHODS: Eighty-one hATTR V30M patients were included: 27 untreated, 25 treated with liver transplantation (LT) and 29 undergoing tafamidis. Neuropathy was assessed at baseline, 12, 24 and 36 months after study entry...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924429/number-location-and-time-since-prior-fracture-as-predictors-of-future-fracture-in-elderly-from-the-general-population
#17
Claudia Beaudoin, Sonia Jean, Lynne Moore, Philippe Gamache, Louis Bessette, Louis-Georges Ste-Marie, Jacques P Brown
Prognostic tools are available to identify individuals at high risk of osteoporotic fracture and assist physicians in management decisions. Some authors have suggested improving the predictive ability of current tools by integrating characteristics of prior fractures (number, location and time since prior fracture). The objectives of this study were i) to evaluate the sex-age-specific association between characteristics of prior fractures and the occurrence of a future osteoporotic fracture and ii) to assess whether the characteristics of prior fractures could increase the discriminative ability of fracture risk prediction tools...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29924428/a-new-fracture-risk-assessment-tool-frem-based-on-public-health-registries
#18
Katrine Hass Rubin, Sören Möller, Teresa Holmberg, Mette Bliddal, Jens Søndergaard, Bo Abrahamsen
BACKGROUND: Some conditions are already known to be associated with increased risk of osteoporotic fractures. Other conditions may also be significant indicators of increased risk. The aim of the study was to identify conditions for inclusion in a fracture prediction model (FREM - Fracture Risk Evaluation Model) for automated case finding of high-risk individuals of hip or major osteoporotic fractures (MOF). MATERIALS AND METHODS: We included the total population in Denmark aged 45+ years (N= 2,495,339)...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29924391/proposal-for-standardized-prenatal-ultrasound-assessment-of-the-fetus-with-congenital-diaphragmatic-hernia-by-the-european-reference-network-on-rare-inherited-and-congenital-anomalies-ernica
#19
REVIEW
Francesca Maria Russo, Anne-Gael Cordier, Luc De Catte, Julien Saada, Alexandra Benachi, Jan Deprest
Congenital diaphragmatic hernia is a rare disease associated with high mortality and morbidity. Antenatal ultrasound screening identifies more than 70% of cases, providing the opportunity for in-utero referral to a tertiary care center for expert assessment and perinatal management. Additional genetic and morphologic assessment may be used to rule out associated anomalies. In isolated cases, the outcome may be predicted prenatally by medical imaging. The combination of lung size and liver herniation is a widely accepted method to stratify fetuses into groups with an increasing degree of pulmonary hypoplasia and corresponding mortality rates...
June 20, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29924388/fat-supplementation-of-human-milk-for-promoting-growth-in-preterm-infants
#20
REVIEW
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: As preterm infants do not experience the nutrient accretion and rapid growth phase of the third trimester of pregnancy, they are vulnerable to postnatal nutritional deficits, including of fat. Consequently, they require higher fat intakes compared to their full term counterparts to achieve adequate growth and development. Human milk fat provides the major energy needs of the preterm infant and also contributes to several metabolic and physiological functions. Although human milk has many benefits for this population, its fat content is highly variable and may be inadequate for their optimum growth and development...
June 19, 2018: Cochrane Database of Systematic Reviews
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