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Alexandre Iarkov, Doreen Appunn, Valentina Echeverria
PURPOSE: Most cancer patients treated with systemic adjuvant chemotherapy endure long-lasting side effects including decrease in concentration, forgetfulness and slower thinking, which are globally termed "chemobrain." Cotinine, the main derivative of nicotine, improved visual and spatial working memory and decreased depressive-like behavior in an animal model of chemotherapy-induced cognitive impairment. METHODS: In this study, we investigated the effect of cotinine on weight gain, locomotor activity, cognitive abilities and depressive-like behavior in rats treated with the chemotherapy mix, cyclophosphamide, methotrexate and 5-fluorouracil...
October 5, 2016: Cancer Chemotherapy and Pharmacology
Ilhan Lim, Hye-Young Joung, A Ram Yu, Insop Shim, Jin Su Kim
A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy. In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET). We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments. According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus...
2016: BioMed Research International
Amelia Maria Gaman, Adriana Uzoni, Aurel Popa-Wagner, Anghel Andrei, Eugen-Bogdan Petcu
Chemobrain or chemotherapy induced cognitive impairment (CICI) represents a new clinical syndrome characterised by memory, learning and motor function impairment. As numerous patients with cancer are long-term survivors, CICI represent a significant factor which may interfere with their quality of life. However, this entity CICI must be distinguished from other cognitive syndromes and addressed accordingly. At the present time, experimental and clinical research suggests that CICI could be induced by numerous factors including oxidative stress...
May 2016: Aging and Disease
Grandhi Venkata Ramalingayya, Pawan G Nayak, Rekha R Shenoy, Chamallamudi Mallikarjuna Rao, Krishnadas Nandakumar
No abstract text is available yet for this article.
September 2016: Clinical and Experimental Pharmacology & Physiology
Sam V Kaplan, Ryan A Limbocker, Rachel C Gehringer, Jenny L Divis, Gregory L Osterhaus, Maxwell D Newby, Michael J Sofis, David P Jarmolowicz, Brooke D Newman, Tiffany A Mathews, Michael A Johnson
Chemotherapy-induced cognitive impairment, known also as "chemobrain", is a medical complication of cancer treatment that is characterized by a general decline in cognition affecting visual and verbal memory, attention, complex problem solving skills, and motor function. It is estimated that one-third of patients who undergo chemotherapy treatment will experience cognitive impairment. Alterations in the release and uptake of dopamine and serotonin, central nervous system neurotransmitters that play important roles in cognition, could potentially contribute to impaired intellectual performance in those impacted by chemobrain...
June 15, 2016: ACS Chemical Neuroscience
Grandhi Venkata Ramalingayya, Madhavan Nampoothiri, Pawan G Nayak, Anoop Kishore, Rekha R Shenoy, Chamallamudi Mallikarjuna Rao, Krishnadas Nandakumar
BACKGROUND: Cognitive decline or dementia is a debilitating problem of neurological disorders such as Alzheimer's and Parkinson's disease, including special conditions like chemobrain. Dietary flavonoids proved to be efficacious in delaying the incidence of neurodegenerative diseases. Two such flavonoids, naringin (NAR) and rutin (RUT) were reported to have neuroprotective potential with beneficial effects on spatial and emotional memories in particular. However, the efficacy of these flavonoids is poorly understood on episodic memory, which comprises an important form of autobiographical memory...
January 2016: Pharmacognosy Magazine
Wenjun Zhou, Annemieke Kavelaars, Cobi J Heijnen
RATIONALE: Chemotherapy-induced cognitive impairment, also known as 'chemobrain', is now widely recognized as a frequent adverse side effect of cancer treatment that often persists into survivorship. There are no drugs available to prevent or treat chemotherapy-induced cognitive deficits. The aim of this study was to establish a mouse model of cisplatin-induced cognitive deficits and to determine the potential preventive effects of the anti-diabetic drug metformin. RESULTS: Treatment of C57/BL6J mice with cisplatin (cumulative dose 34...
2016: PloS One
Grandhi Venkata Ramalingayya, Karthik Gourishetti, Anoop Kishore, Krishnadas Nandakumar
No abstract text is available yet for this article.
June 2016: Clinical and Experimental Pharmacology & Physiology
Dénes Kleiner, Ágnes Szilvás, Klára Szentmihályi, Krisztina Süle, Anna Blázovics
Nowadays it has been established that metals and metal-induced oxidative stress act on signal transduction pathways, and are in association with cancer growth and spreading as well as in neurodegenerative disorders. In cases of several neurodegenerative diseases metals, especially Al, can be considered as a risk factor. Frequency of chemotherapy-related cognitive impairment or "chemobrain" is mentioned to be significant in literature, although very little is known about the chemotherapy-caused chemobrain and its connection with metal homeostasis alteration...
January 2016: Journal of Trace Elements in Medicine and Biology
Diane F Morean, Linda O'Dwyer, Leora R Cherney
OBJECTIVE: To systematically review evidence of treatments for cognitive impairments experienced by at least 20% of all women who undergo chemotherapy for breast cancer. DATA SOURCES: Searches of 5 databases (PubMed, Embase, Cochrane CENTRAL, PsycINFO, CINAHL), with no date or language restrictions, identified 1701 unique results. Search terms included breast cancer, chemotherapy, chemobrain, chemofog, and terms on cognition and language deficits. STUDY SELECTION: Included only peer-reviewed journal articles that described therapies for cognitive dysfunction in women undergoing (or who had undergone) chemotherapy for breast cancer and provided objective measurements of cognition or language...
October 2015: Archives of Physical Medicine and Rehabilitation
Akina Natori, Toru Ogata, Hideko Yamauchi
No abstract text is available yet for this article.
May 2015: Aging
Charlotte K Callaghan, Shane M O'Mara
Clinical studies report evidence of long-term cognitive and other deficits following adjunctive chemotherapy treatment, which is often termed "chemobrain" or "chemo-fog". The neurological bases of these impairments are poorly understood. Here, we hypothesize that systemic chemotherapy treatment causes long-term neurobehavioral deficits, and that these deficits are reversed by manipulation of cAMP by the PDE4 inhibitor, rolipram. Male han Wistar rats were treated with docetaxel (an adjunctive chemotherapeutic agent (1mg/kg i...
September 1, 2015: Behavioural Brain Research
Brent J Small, Stacey B Scott, Heather S L Jim, Paul B Jacobsen
With advances in screening and early detection, coupled with improved treatment and care, the number of cancer survivors has risen exponentially over the past several decades. Moreover, because age is the most significant risk factor for cancer, the majority of cancer survivors are over 65 years of age. Finally, cancer survivors often experience significant health issues for many years after the treatment has subsided. In the current article, we describe select research that has focused on changes to cognitive performance associated with cancer and its treatment, i...
2015: Gerontology
Munjal M Acharya, Vahan Martirosian, Nicole N Chmielewski, Nevine Hanna, Katherine K Tran, Alicia C Liao, Lori-Ann Christie, Vipan K Parihar, Charles L Limoli
The frequent use of chemotherapy to combat a range of malignancies can elicit severe cognitive dysfunction often referred to as "chemobrain," a condition that can persist long after the cessation of treatment in as many as 75% of survivors. Although cognitive health is a critical determinant of therapeutic outcome, chemobrain remains an unmet medical need that adversely affects quality of life in pediatric and adult cancer survivors. Using a rodent model of chemobrain, we showed that chronic cyclophosphamide treatment induced significant performance-based decrements on behavioral tasks designed to interrogate hippocampal and cortical function...
February 15, 2015: Cancer Research
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0108002.].
2015: PloS One
Xiao-Min Wang, Brian Walitt, Leorey Saligan, Agnes F Y Tiwari, Chi Wai Cheung, Zhang-Jin Zhang
One consequence of modern cancer therapy is chemotherapy related cognitive dysfunction or "chemobrain", the subjective experience of cognitive deficits at any point during or following chemotherapy. Chemobrain, a well-established clinical syndrome, has become an increasing concern because the number of long-term cancer survivors is growing dramatically. There is strong evidence that correlates changes in peripheral cytokines with the development of chemobrain in commonly used chemotherapeutic drugs for different types of cancer...
March 2015: Cytokine
Maryam Hafsah Selamat, Siew Yim Loh, Lynette Mackenzie, Janette Vardy
BACKGROUND: Cognitive impairment, colloquially termed "chemobrain", occurs in 10-40% of all cancer patients, and is an emerging target of cancer survivorship research. AIM: This study reviews published qualitative studies to explore cognitive impairments or chemobrain among breast cancer survivors, with particular attention given to the impact on quality of life. METHOD: Using keywords, we searched ten electronic databases (CINAHL, EMBASE, Proquest, OVID SP, MEDLINE, Oxford Journal, Science Direct, PubMED)...
2014: PloS One
Sunita K Patel, Arti Hurria, Jeanne S Mandelblatt
No abstract text is available yet for this article.
September 2014: Oncology (Williston Park, NY)
Halle C F Moore
Chemotherapy can improve prospects for long-term survival after a cancer diagnosis, but it may also be associated with long-term toxicity, including the possibility of cognitive dysfunction. While a variety of factors may contribute to cognitive impairment in cancer survivors, there is increasing evidence that chemotherapy contributes to both subjective and objective changes in cognition. These effects appear to be most pronounced in the short-term, with improvement over time expected for most patients. Pharmacologic treatments do not have proven value in the management of chemotherapy-related cognitive dysfunction, but patients may benefit from cognitive rehabilitation...
September 2014: Oncology (Williston Park, NY)
Laura L Boles Ponto, Yusuf Menda, Vincent A Magnotta, Torricia H Yamada, Natalie L Denburg, Susan K Schultz
PURPOSE: The term "chemobrain" is sometimes used to denote deficits in neuropsychological functioning that may occur as a result of cancer treatment. As breast cancer survivors now commonly reach late life, it is not known whether previous exposure to chemotherapy may affect long-term risk for cognitive impairment. To help address this concern, this study tested whether successfully surviving chemotherapy earlier in life was associated with later differences in brain metabolic function as an older adult compared to controls...
June 2015: International Journal of Geriatric Psychiatry
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