Andrew M Clark, Alexander Ingold, Christopher F Reiche, Donald Cundy, Justin L Balsor, Frederick Federer, Niall McAlinden, Yunzhou Cheng, John D Rolston, Loren Rieth, Martin D Dawson, Keith Mathieson, Steve Blair, Alessandra Angelucci
Optogenetics has transformed studies of neural circuit function, but remains challenging to apply to non-human primates (NHPs). A major challenge is delivering intense, spatiotemporally-precise, patterned photostimulation across large volumes in deep tissue. Such stimulation is critical, for example, to modulate selectively deep-layer corticocortical feedback circuits. To address this need, we have developed the Utah Optrode Array (UOA), a 10×10 glass needle waveguide array fabricated atop a novel opaque optical interposer, and bonded to an electrically addressable µLED array...
March 14, 2024: Communications Biology