keyword
MENU ▼
Read by QxMD icon Read
search

Novel device

keyword
https://www.readbyqxmd.com/read/28813055/multivesicular-droplets-a-cell-model-system-to-study-compartmentalised-biochemical-reactions
#1
N Nuti, P E Verboket, P S Dittrich
Multivesicular vesicles (MVVs) are artificial liposomal structures widely used as a platform to study the compartmentalisation of cells and as a scaffold for artificial cell/protocell models. Current preparation techniques for MVVs, however, offer poor control on the size, lamellarity, and loading of inner lipid vesicles. Here, we introduce a microfluidic device for the production of multivesicular droplets (MVDs): a novel model system combining the ease of use and control of droplet microfluidics with the biological relevance of MVVs...
August 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28812983/a-microfluidic-platform-for-modeling-metastatic-cancer-cell-matrix-invasion
#2
Laura Blaha, Chentian Zhang, Mario Cabodi, Joyce Y Wong
Invasion of the extracellular matrix is a critical step in the colonization of metastatic tumors. The invasion process is thought to be driven by both chemokine signaling and interactions between invading cancer cells and physical components of the metastatic niche, including endothelial cells that line capillary walls and serve as a barrier to both diffusion and invasion of the underlying tissue. Transwell chambers, a tool for generating artificial chemokine gradients to induce cell migration, have facilitated recent work to investigate the chemokine contributions to matrix invasion...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812871/high-performance-porous-molybdenum-oxynitride-based-fiber-supercapacitors
#3
Dan Ruan, Rui Lin, Kui Jiang, Xiang Yu, Yaofeng Zhu, Yaqin Fu, Zilong Wang, He Yan, Wenjie Mai
Scalable manufacturing of flexible, fiber-shaped energy storage devices has enabled great technological advances in wearable and portable technology. Replacing inefficient oxides with inexpensive and high-performance oxynitrides with more favourable 3D structures is critical if the practical applications of these technologies are to be realised. Here we developed a facile and controllable approach for the synthesis of 3D porous micropillars of molybdenum oxynitride, which exhibit high conductivity, robust stability and excellent energy storage properties...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812354/3d-moldable-nanofiber-reinforced-transparent-composites-with-hierarchically-self-assembled-reverse-nacre-like-architecture
#4
Subir Kumar Biswas, Hironari Sano, Md Iftekhar Shams, Hiroyuki Yano
Achieving structural hierarchy and a uniform nanofiller dispersion simultaneously remains highly challenging for obtaining a robust polymer nanocomposite of immiscible components. In this study, a remarkably facile Pickering emulsification approach is developed to fabricate hierarchical composites of immiscible acrylic polymer and native cellulose nanofibers by taking advantage of the dual role of the nanofibers as both the emulsion stabilizer and polymer reinforcement. The composites feature a unique "reverse" nacre-like microstructure reinforced with well-dispersed two-tier hierarchical nanofiber network, leading to a synergistic high strength, modulus, and toughness (20, 50, and 53 times that of neat polymer, respectively), high optical transparency (89%), high flexibility and a drastically low thermal expansion (13 ppm/K, 1/15th of the neat polymer)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812281/preclinical-development-of-an-automated-injection-device-for-intradermal-delivery-of-a-cell-based-therapy
#5
Giulia Leoni, Alex Lyness, Patrick Ginty, Rindi Schutte, Gopalan Pillai, Gayatri Sharma, Paul Kemp, Natalie Mount, Michaela Sharpe
Current methods for intradermal delivery of therapeutic products in clinical use include manual injection via the Mantoux technique and the use of injection devices, primarily developed for the delivery of vaccines and small molecules. A novel automated injection device is presented specifically designed for accurate delivery of multiple doses of product through a number of adjustable injection parameters, including injection depth, dose volume and needle insertion speed. The device was originally conceived for the delivery of a cell-based therapy to patients with skin wounds caused by epidermolysis bullosa...
August 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28812089/large-scale-all-polycrystalline-diamond-structures-transferred-onto-flexible-parylene-c-films-for-neurotransmitter-sensing
#6
Bin Fan, Yan Zhu, Robert Rechenberg, Cory A Rusinek, Michael F Becker, Wen Li
Boron-doped diamond (BDD) has superior electrochemical properties for bioelectronic systems. However, due to its high synthesis temperature, traditional microfabrication methods have limits to integrating BDD with emerging classes of flexible, polymer-based bioelectronic systems. This paper introduces a novel fabrication solution to this challenge, which features (i) a wafer-scale substrate transfer process with all diamond structures transferred onto a flexible Parylene-C substrate and (ii) Parylene anchors introduced to strengthen the bonding between BDD and Parylene substrates, as demonstrated by a peeling test...
August 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28811983/a-novel-spinal-implant-for-fusionless-scoliosis-correction-a-biomechanical-analysis-of-the-motion-preserving-properties-of-a-posterior-periapical-concave-distraction-device
#7
Roderick M Holewijn, Marinus de Kleuver, Albert J van der Veen, Kaj S Emanuel, Arno Bisschop, Agnita Stadhouder, Barend J van Royen, Idsart Kingma
STUDY DESIGN: Biomechanical study. OBJECTIVE: Recently, a posterior concave periapical distraction device for fusionless scoliosis correction was introduced. The goal of this study was to quantify the effect of the periapical distraction device on spinal range of motion (ROM) in comparison with traditional rigid pedicle screw-rod instrumentation. METHODS: Using a spinal motion simulator, 6 human spines were loaded with 4 N m and 6 porcine spines with 2 N m to induce flexion-extension (FE), lateral bending (LB), and axial rotation (AR)...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811586/modulating-sound-with-acoustic-metafiber-bundles
#8
Jian-Ping Xia, Hong-Xiang Sun, Shou-Qi Yuan
Acoustic metamaterials and metasurfaces provide great flexibility for manipulating sound waves and promise unprecedented functionality, ranging from transformation acoustics, acoustic cloaking, acoustic imaging to acoustic rerouting. However, the design of artificial structures with both broad bandwidth and multifunctionality remains challenging with traditional design approaches. Here we present a design and realization of a broadband acoustic metafiber bundle. Very different from previously reported acoustic metamaterials and metasurfaces, not only the metafiber structure is simple, flexible and tunable, but also the metafiber bundle has the advantages of broad bandwidth, high transmission, no resonance-induced energy loss and unchangeable output wavefront owing to eigenmodes in the passbands of the metafiber...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811577/dirac-point-induced-ultralow-threshold-laser-and-giant-optoelectronic-quantum-oscillations-in-graphene-based-heterojunctions
#9
Golam Haider, Rini Ravindranath, Tzu-Pei Chen, Prathik Roy, Pradip Kumar Roy, Shu-Yi Cai, Huan-Tsung Chang, Yang-Fang Chen
The occurrence of zero effective mass of electrons at the vicinity of the Dirac point is expected to create new paradigms for scientific research and technological applications, but the related discoveries are rather limited. Here, we demonstrate that a simple architecture composed of graphene quantum dots sandwiched by graphene layers can exhibit several intriguing features, including the Dirac point induced ultralow-threshold laser, giant peak-to-valley ratio (PVR) with ultra-narrow spectra of negative differential resistance and quantum oscillations of current as well as light emission intensity...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811481/leaky-integrate-and-fire-neuron-by-charge-discharge-dynamics-in-floating-body-mosfet
#10
Sangya Dutta, Vinay Kumar, Aditya Shukla, Nihar R Mohapatra, Udayan Ganguly
Neuro-biology inspired Spiking Neural Network (SNN) enables efficient learning and recognition tasks. To achieve a large scale network akin to biology, a power and area efficient electronic neuron is essential. Earlier, we had demonstrated an LIF neuron by a novel 4-terminal impact ionization based n+/p/n+ with an extended gate (gated-INPN) device by physics simulation. Excellent improvement in area and power compared to conventional analog circuit implementations was observed. In this paper, we propose and experimentally demonstrate a compact conventional 3-terminal partially depleted (PD) SOI- MOSFET (100 nm gate length) to replace the 4-terminal gated-INPN device...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810771/switching-dynamics-in-cholesteric-liquid-crystal-emulsions
#11
F Fadda, G Gonnella, D Marenduzzo, E Orlandini, A Tiribocchi
In this work we numerically study the switching dynamics of a 2D cholesteric emulsion droplet immersed in an isotropic fluid under an electric field, which is either uniform or rotating with constant speed. The overall dynamics depend strongly on the magnitude and on the direction (with respect to the cholesteric axis) of the applied field, on the anchoring of the director at the droplet surface and on the elasticity. If the surface anchoring is homeotropic and a uniform field is parallel to the cholesteric axis, the director undergoes deep elastic deformations and the droplet typically gets stuck into metastable states which are rich in topological defects...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810732/tracking-radionuclide-fractionation-in-the-first-atomic-explosion-using-stable-elements
#12
Chloe E Bonamici, Richard L Hervig, William S Kinman
Compositional analysis of post-detonation fallout is a tool for forensic identification of nuclear devices. However, the relationship between device composition and fallout composition is difficult to interpret because of the complex combination of physical mixing, nuclear reactions, and chemical fractionations that occur in the chaotic nuclear fireball. Using a combination of in situ microanalytical techniques - electron microprobe analysis and secondary ion mass spectrometry - we show that some heavy stable elements (Rb, Sr, Zr, Ba, Cs, Ba, La, Ce, Nd, Sm, Dy, Lu, U, Th) in glassy fallout from the first nuclear test, Trinity, are reliable chemical proxies for radionuclides generated during the explosion...
August 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28809712/a-novel-intracranial-pressure-readout-circuit-for-passive-wireless-lc-sensor
#13
Fa Wang, Xuan Zhang, Mehdi Shokoueinejad, Bermans J Iskandar, Joshua E Medow, John G Webster
We present a wide frequency range, low cost, wireless intracranial pressure monitoring system, which includes an implantable passive sensor and an external reader. The passive sensor consists of two spiral coils and transduces the pressure change to a resonant frequency shift. The external portable reader reads out the sensor's resonant frequency over a wide frequency range (35 MHz-2.7 GHz). We propose a novel circuit topology, which tracks the system's impedance and phase change at a high frequency with low-cost components...
August 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28809704/kilohertz-electrical-stimulation-nerve-conduction-block-effects-of-electrode-material
#14
Yogi A Patel, Brian S Kim, Robert J Butera
Kilohertz electrical stimulation (KES) has enabled a novel new paradigm for spinal cord and peripheral nerve stimulation to treat a variety of neurological diseases. KES can excite or inhibit nerve activity and is used in many clinical devices today. However, the impact of different electrode materials on the efficacy of KES is unknown. We investigated the effect of different electrode materials and their respective charge injection mechanisms on KES nerve block thresholds using 20 and 40 kHz current-controlled sinusoidal KES waveforms...
August 10, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28809696/real-time-view-correction-for-mobile-devices
#15
Thomas Schops, Martin R Oswald, Pablo Speciale, Shuoran Yang, Marc Pollefeys
We present a real-time method for rendering novel virtual camera views from given RGB-D (color and depth) data of a different viewpoint. Missing color and depth information due to incomplete input or disocclusions is efficiently inpainted in a temporally consistent way. The inpainting takes the location of strong image gradients into account as likely depth discontinuities. We present our method in the context of a view correction system for mobile devices, and discuss how to obtain a screen-camera calibration and options for acquiring depth input...
August 10, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28809573/intrinsic-plasmon-phonon-interactions-in-highly-doped-graphene-a-near-field-imaging-study
#16
Francisco J Bezares, Adolfo De Sanctis, Jose R M Saavedra, Achim Woessner, Pablo Alonso-González, Iban Amenabar, Jianing Chen, Thomas Bointon, Siyuan Dai, Michael M Fogler, D N Basov, Rainer Hillenbrand, Monica Felicia Craciun, F Javier Garcia de Abajo, Saverio Russo, Frank H L Koppens
As a two-dimensional semi-metal, graphene offers clear advantages for plasmonic applications over conventional metals, such as stronger optical field confinement, in situ tunability and relatively low intrinsic losses. However, the operational frequencies at which plasmons can be excited in graphene are limited by the Fermi energy EF, which in practice can be controlled electrostatically only up to a few tenths of an electronvolt. Higher Fermi energies open the door to novel plasmonic devices with unprecedented capabilities, particularly at mid-infrared and shorter-wave infrared frequencies...
August 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/28809085/electric-and-mechanical-switching-of-ferroelectric-and-resistive-states-in-semiconducting-batio3-%C3%AE-films-on-silicon
#17
Andrés Gómez, José Manuel Vila-Fungueiriño, Rahma Moalla, Guillaume Saint-Girons, Jaume Gázquez, María Varela, Romain Bachelet, Martí Gich, Francisco Rivadulla, Adrián Carretero-Genevrier
Materials that can couple electrical and mechanical properties constitute a key element of smart actuators, energy harvesters, or many sensing devices. Within this class, functional oxides display specific mesoscale responses which often result in great sensitivity to small external stimuli. Here, a novel combination of molecular beam epitaxy and a water-based chemical-solution method is used for the design of mechanically controlled multilevel device integrated on silicon. In particular, the possibility of adding extra functionalities to a ferroelectric oxide heterostructure by n-doping and nanostructuring a BaTiO3 thin film on Si(001) is explored...
August 15, 2017: Small
https://www.readbyqxmd.com/read/28808270/a-low-permeability-microfluidic-blood-brain-barrier-platform-with-direct-contact-between-perfusable-vascular-network-and-astrocytes
#18
Seokyoung Bang, Seung-Ryeol Lee, Jihoon Ko, Kyungmin Son, Dongha Tahk, Jungho Ahn, Changkyun Im, Noo Li Jeon
A novel three dimensional blood brain barrier (BBB) platform was developed by independently supplying different types of media to separate cell types within a single device. One channel (vascular channel, VC) is connected to the inner lumen of the vascular network while the other supplies media to the neural cells (neural channel, NC). Compared to co-cultures supplied with only one type of medium (or 1:1 mixture), best barrier properties and viability were obtained with culturing HUVECs with endothelial growth medium (EGM) and neural cells with neurobasal medium supplemented with fetal bovine serum (NBMFBS) independently...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807074/a-model-to-predict-central-line-associated-bloodstream-infection-among-patients-with-peripherally-inserted-central-catheters-the-mpc-score
#19
Erica Herc, Payal Patel, Laraine L Washer, Anna Conlon, Scott A Flanders, Vineet Chopra
BACKGROUND Peripherally inserted central catheters (PICCs) are associated with central-line-associated bloodstream infections (CLABSIs). However, no tools to predict risk of PICC-CLABSI have been developed. OBJECTIVE To operationalize or prioritize CLABSI risk factors when making decisions regarding the use of PICCs using a risk model to estimate an individual's risk of PICC-CLABSI prior to device placement. METHODS Using data from the Michigan Hospital Medicine Safety consortium, patients that experienced PICC-CLABSI between January 2013 and October 2016 were identified...
August 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28806989/maximising-value-from-a-united-kingdom-biomedical-research-centre-study-protocol
#20
Trisha Greenhalgh, Pavel V Ovseiko, Nick Fahy, Sara Shaw, Polly Kerr, Alexander D Rushforth, Keith M Channon, Vasiliki Kiparoglou
BACKGROUND: Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research...
August 14, 2017: Health Research Policy and Systems
keyword
keyword
8150
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"