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Water electrolyte physiology

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https://www.readbyqxmd.com/read/29771471/fluorescent-ph-responsive-probes-based-on-water-soluble-bodipy-featuring-long-wavelength-emission
#1
Gilles Ulrich, Alexandra Sutter, Mourad Elhabiri
We describe here the synthesis of water soluble Red-NIR emissive BODIPY derivatives displaying optical (absorption and emission) responses in pH ranges of interest. Substitution effects close to the tertiary aniline or the phenol subunits selected as the proton sensitive sites allowed us to finely tune the pH ranges. Furthermore, introduction of sulfobetaine functions at the boron centre of these pH responsive BODIPYs afforded valuable fluorescent dyes in the Red-NIR region in aqueous media, for which the steric hindrance and electrostatic repulsions prevent their non emissive aggregation...
May 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29767557/polycystin-1-dysfunction-impairs-electrolyte-and-water-handling-in-a-renal-pre-cystic-mouse-model-for-adpkd
#2
Eric H J Verschuren, Sami G Mohammed, Wouter N Leonhard, Caro Overmars-Bos, Kimberly A M Veraar, Joost G J Hoenderop, René J M Bindels, Dorien J M Peters, Francisco J Arjona
The PKD1 gene encodes polycystin-1 (PC1), a mechanosensor triggering intracellular responses upon urinary flow sensing in kidney tubular cells. Mutations in PKD1 lead to autosomal dominant polycystic kidney disease (ADPKD). The involvement of PC1 in renal electrolyte handling remains unknown since renal electrolyte physiology in ADPKD patients has only been characterized in cystic ADPKD. We thus studied the renal electrolyte handling in inducible kidney-specific Pkd1 knockout (iKsp-Pkd1-/-) mice manifesting a pre-cystic phenotype...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29758100/diagnostic-approach-to-low-renin-hypertension
#3
Silvia Monticone, Isabel Losano, Martina Tetti, Fabrizio Buffolo, Franco Veglio, Paolo Mulatero
Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homeostasis and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanisms underlying the development of both essential and secondary hypertension has occurred. Approximatively 25% of the patients affected by arterial hypertension display low renin levels, a definition that is largely arbitrary and depends on the investigated population and the specific characteristics of the assay...
May 14, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29740578/using-electrolyte-free-water-balance-to-rationalize-and-treat-dysnatremias
#4
REVIEW
Sanjeev R Shah, Gautam Bhave
Dysnatremias or abnormalities in plasma [Na+ ] are often termed disorders of water balance, an unclear physiologic concept often confused with changes in total fluid balance. However, most clinicians clearly recognize that hypertonic or hypotonic gains or losses alter plasma [Na+ ], while isotonic changes do not modify plasma [Na+ ]. This concept can be conceptualized as the electrolyte free water balance (EFWB), which defines the non-isotonic components of inputs and outputs to determine their effect on plasma [Na+ ]...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29738573/1h-nmr-metabolomic-profiling-reveals-a-distinct-metabolic-recovery-response-in-shoots-and-roots-of-temporarily-drought-stressed-sugar-beets
#5
Rita Wedeking, Mickaël Maucourt, Catherine Deborde, Annick Moing, Yves Gibon, Heiner E Goldbach, Monika A Wimmer
Yield formation in regions with intermittent drought periods depends on the plant's ability to recover after cessation of the stress. The present work assessed differences in metabolic recovery of leaves and roots of drought-stressed sugar beets with high temporal resolution. Plants were subjected to drought for 13 days, and rewatered for 12 days. At one to two-day intervals, plant material was harvested for untargeted 1H-NMR metabolomic profiling, targeted analyses of hexose-phosphates, starch, amino acids, nitrate and proteins, and physiological measurements including relative water content, osmotic potential, electrolyte leakage and malondialdehyde concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29712884/imbalance-of-gut-microbiome-and-intestinal-epithelial-barrier-dysfunction-in-cardiovascular-disease
#6
Judith N Lezutekong, Anish Nikhanj, Gavin Y Oudit
The main function of the intestinal barrier is to regulate the absorption of nutrients, electrolytes, and water from the lumen into circulation and to prevent the entry of pathogenic microorganisms and toxic luminal substances. To maintain this function, an ideal microbiota balance is required and gut microbiota are critical for the intestinal epithelial barrier dysfunction and for the maintenance of physiological homeostasis. There is a demonstrable link between dysbiosis and intestinal dysfunction and diseases such as diabetes, obesity, and cardiovascular disease...
April 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29700220/intensive-care-management-of-severe-hypernatraemia-in-the-context-of-group-a-streptococcal-septicaemia
#7
Bethan Davies, Robert Jesty, Shahana Uddin, Victoria Metaxa
This case describes a 54-year-old woman with exudative eczema, who was admitted to the intensive care unit with a serum sodium concentration of 191 mmol/L, secondary to profound dehydration in the context of group A streptococcal septicaemia. Successful rehydration and electrolyte normalisation was achieved with continuous venovenous haemodiafiltration (CVVHDF), the replacement fluid of which was infused with hypertonic saline to limit the rate of sodium reduction. This case report comments on three areas of interest...
April 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29687889/slc9-gene-family-function-expression-and-regulation
#8
Hua Xu, Fayez K Ghishan, Pawel R Kiela
The Slc9 family of Na+ /H+ exchangers (NHEs) plays a critical role in electroneutral exchange of Na+ and H+ in the mammalian intestine as well as other absorptive and secretory epithelia of digestive organs. These transport proteins contribute to the transepithelial Na+ and water absorption, intracellular pH and cellular volume regulation as well as the electrolyte, acid-base, and fluid volume homeostasis at the systemic level. They also influence the function of other membrane transport mechanisms, affect cellular proliferation and apoptosis as well as cell migration, adherence to the extracellular matrix, and tissue repair...
March 26, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29650370/open-boundary-molecular-dynamics-of-a-dna-molecule-in-a-hybrid-explicit-implicit-salt-solution
#9
Julija Zavadlav, Jurij Sablić, Rudolf Podgornik, Matej Praprotnik
The composition and electrolyte concentration of the aqueous bathing environment have important consequences for many biological processes and can profoundly affect the behavior of biomolecules. Nevertheless, because of computational limitations, many molecular simulations of biophysical systems can be performed only at specific ionic conditions: either at nominally zero salt concentration, i.e., including only counterions enforcing the system's electroneutrality, or at excessive salt concentrations. Here, we introduce an efficient molecular dynamics simulation approach for an atomistic DNA molecule at realistic physiological ionic conditions...
April 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29602756/tolvaptan-for-heart-failure-in-chronic-kidney-disease-patients-a-systematic-review-and-meta-analysis
#10
REVIEW
Jonathan Sen, Erin Chung, Darryl McGill
BACKGROUND: Heart failure (HF) is frequently associated with renal impairment. Tolvaptan is reported to be effective in treating congestion in HF without significant electrolyte loss compared to conventional diuretics. However, the safety and efficacy of its use in patients with chronic kidney disease (CKD) is uncertain. This systematic review and meta-analysis evaluated the efficacy and safety outcomes of tolvaptan for HF management in patients with CKD, with a focus at a physiologic basis related to safety...
February 13, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29556787/dysregulation-of-the-renin-angiotensin-system-and-the-vasopressinergic-system-interactions-in-cardiovascular-disorders
#11
REVIEW
Ewa Szczepanska-Sadowska, Katarzyna Czarzasta, Agnieszka Cudnoch-Jedrzejewska
PURPOSE OF REVIEW: In many instances, the renin-angiotensin system (RAS) and the vasopressinergic system (VPS) are jointly activated by the same stimuli and engaged in the regulation of the same processes. RECENT FINDINGS: Angiotensin II (Ang II) and arginine vasopressin (AVP), which are the main active compounds of the RAS and the VPS, interact at several levels. Firstly, Ang II, acting on AT1 receptors (AT1R), plays a significant role in the release of AVP from vasopressinergic neurons and AVP, stimulating V1a receptors (V1aR), regulates the release of renin in the kidney...
March 19, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29541861/internalization-of-nkcc2-is-impaired-in-thick-ascending-limb-of-henle-in-moesin-knockout-mice
#12
Kotoku Kawaguchi, Ryo Hatano, Mitsunobu Matsubara, Shinji Asano
Moesin is expressed in several types of cells including epithelial and endothelial cells. Several groups reported that moesin plays important roles in the regulation of the cellular motility, and the process of internalization of membrane proteins. However, the physiological roles of moesin in the kidney still remain unclear. Herein, we examined the physiological function of moesin in the kidney using moesin knockout (Msn -/y ) mice. There was no obvious abnormality in the renal morphology of Msn -/y mice. However, we found that Msn -/y mice exhibited mild hyperchloremia, and reduced glomerular filtration rate compared to wild type (WT) mice...
March 15, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29520986/assessment-of-electrolytes-and-metals-profile-of-the-faro-lake-capo-peloro-lagoon-sicily-italy-and-its-impact-on-mytilus-galloprovincialis
#13
Gioele Capillo, Serena Silvestro, Marilena Sanfilippo, Emma Fiorino, Giuseppe Giangrosso, Vincenzo Ferrantelli, Irene Vazzana, Caterina Faggio
Faro Lake is a coastal meromictic lagoon with singular characteristics in the Mediterranean (Messina, Sicily - Italy). It is part of the Natural Oriented Reserve of Capo Peloro (38° 15' 57″ N; 15° 37' 50″ E). In this area, traditional mollusc farming activity persists, producing 'autochthonous' mussels. This study reports of the Mytilus galloprovincialis haemolymph chemical profile and water variables determination of 1 year-lasted survey (April 2016 - March 2017). The determinations of electrolytes (Na+ , Cl- , K+ , Ca2+ , Mg2+ , P inorganic) and heavy metals in both Faro lake water and haemolymph have been carried out...
March 9, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29518657/magnesium-and-organic-biostimulant-integrative-application-induces-physiological-and-biochemical-changes-in-sunflower-plants-and-its-harvested-progeny-on-sandy-soil
#14
Hafeez Ur Rehman, Hesham F Alharby, Yahya Alzahrani, Mostafa M Rady
Magnesium (Mg) often leaches down in sandy soils due to high mobility and its foliar application proves to be beneficial. Organic biostimulants also prove to be helpful to affect plant physio-biochemistry and antioxidative defense system. The present study evaluated the beneficial effects of seed soaking in maize grain extract (MGE; 3%) in integration with or without foliar Mg (1 mM) in comparison to control (no treatment) on growth, yield performance, seed oil and fatty acid profile including physiological and biochemical basis of Hysun-336 sunflower hybrid grown on a sandy soil under greenhouse conditions...
May 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29479433/blood-analytes-of-oceanic-juvenile-loggerhead-sea-turtles-caretta-caretta-from-azorean-waters-reference-intervals-size-relevant-correlations-and-comparisons-to-neritic-loggerheads-from-western-atlantic-coastal-waters
#15
Nicole I Stacy, Karen A Bjorndal, Justin R Perrault, Helen R Martins, Alan B Bolten
Blood analyte reference intervals are scarce for immature life stages of the loggerhead sea turtle ( Caretta caretta ). The objectives of this study were to (1) document reference intervals of packed cell volume (PCV) and 20 plasma chemistry analytes from wild oceanic-juvenile stage loggerhead turtles from Azorean waters, (2) investigate correlations with body size (minimum straight carapace length: SCLmin ) and (3) compare plasma chemistry data to those from older, larger neritic juveniles (<80 cm SCLmin ) and adult loggerheads (≥80 cm SCLmin ) that have recruited to the West Atlantic in waters around Cape Canaveral, Florida...
2018: Conservation Physiology
https://www.readbyqxmd.com/read/29475124/the-defensive-role-of-silicon-in-wheat-against-stress-conditions-induced-by-drought-salinity-or-cadmium
#16
Yahya Alzahrani, Alpaslan Kuşvuran, Hesham F Alharby, Sebnem Kuşvuran, Mostafa M Rady
In the crust of earth, silicon (Si) is one of the two major elements. For plant growth and development, importance of Si remains controversial due to the widely differences in ability of plants to take up this element. In this paper, pot experiments were done to study Si roles in improving salt, drought or cadmium (Cd) stress tolerance in wheat. Up to full emergence, all pots were watered at 100% field capacity (FC) every other day with nutrient solution without any treatments. Fifteen days after sowing, pots were divided into four plots, each with 40 pots for no stress (control) and three stress treatments; drought (50% FC), salinity (200 mM NaCl) and cadmium (2 mM Cd)...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29460274/a-perfusion-chamber-for-monitoring-transepithelial-nacl-transport-in-an-in-vitro-model-of-the-renal-tubule
#17
Jose Yeste, Laura Martínez-Gimeno, Xavi Illa, Pablo Laborda, Anton Guimerà, Juan P Sánchez-Marín, Rosa Villa, Ignacio Giménez
Transepithelial electrical measurements in the renal tubule have provided a better understanding of how kidney regulates electrolyte and water homeostasis through the reabsorption of molecules and ions (e.g., H2 O and NaCl). While experiments and measurement techniques using native tissue are difficult to prepare and to reproduce, cell cultures conducted largely with the Ussing chamber lack the effect of fluid shear stress which is a key physiological stimulus in the renal tubule. To overcome these limitations, we present a modular perfusion chamber for long-term culture of renal epithelial cells under flow that allows the continuous and simultaneous monitoring of both transepithelial electrical parameters and transepithelial NaCl transport...
June 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29430274/direct-enrichment-of-pathogens-from-physiological-samples-of-high-conductivity-and-viscosity-using-h-filter-and-positive-dielectrophoresis
#18
Dongyang Cai, Qiaolian Yi, Chaohua Shen, Ying Lan, Gerald Urban, Wenbin Du
The full potential of microfluidic techniques as rapid and accurate methods for the detection of disease-causing agents and foodborne pathogens is critically limited by the complex sample preparation process, which commonly comprises the enrichment of bacterial cells to detectable levels. In this manuscript, we describe a microfluidic device which integrates H-filter desalination with positive dielectrophoresis (pDEP) for direct enrichment of bacterial cells from physiological samples of high conductivity and viscosity, such as cow's milk and whole human blood...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29398845/genetic-diversity-of-cucumber-estimated-by-morpho-physiological-and-est-ssr-markers
#19
Sudhakar Pandey, Waquar Akhter Ansari, Maneesh Pandey, Bijendra Singh
In the present study, genetic variation among 40 cucumber genotypes was analyzed by means of morpho-physiological traits and 21 EST-SSR markers. Diversity was observed for morpho-physiological characters like days to 50% female flowering (37-46.9, number of fruits/plant (1.33-5.80), average fruit weight (41-333), vine length (36-364), relative water content (58.5-92.7), electrolyte leakage (15.9-37.1), photosynthetic efficiency (0.40-0.75) and chlorophyll concentration index (11.1-28.6). The pair wise Jaccard similarity coefficient ranged from 0...
February 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29357439/circadian-regulation-of-kidney-function-finding-a-role-for-bmal1
#20
Dingguo Zhang, David M Pollock
Mounting evidence suggests that there is an internal molecular "clock" within the kidney to help maintain normal renal function. Disturbance of the kidney circadian rhythm may pose a threat to water and electrolyte homeostasis and blood pressure regulation, amongst many other problems. The identification of circadian genes facilitated a more comprehensive appreciation of the importance of "keeping the body on time"; however, our knowledge is very limited with regard to how circadian genes regulate kidney function...
December 20, 2017: American Journal of Physiology. Renal Physiology
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