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anal intraepithelial neoplasia

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https://www.readbyqxmd.com/read/27917295/circulating-human-papillomavirus-dna-detected-using-droplet-digital-pcr-in-the-serum-of-patients-diagnosed-with-early-stage-human-papillomavirus-associated-invasive-carcinoma
#1
Emmanuelle Jeannot, Véronique Becette, Maura Campitelli, Marie-Ange Calméjane, Emmanuelle Lappartient, Evelyne Ruff, Stéphanie Saada, Allyson Holmes, Dominique Bellet, Xavier Sastre-Garau
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours. Here we took advantage of the sensitive droplet digital PCR method to identify circulating human papillomavirus DNA in patients with human papillomavirus-associated carcinomas...
October 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27845952/human-papillomavirus-as-a-cause-of-anal-cancer-and-the-role-of-screening
#2
Karien C M Gosens, Olivier Richel, Jan M Prins
PURPOSE OF REVIEW: Anal cancer is a serious health problem in HIV-positive men who have sex with men, and precursor lesions, anal intraepithelial neoplasia, are well defined. Given the similarities with cervical cancer, screening for and treatment of anal intraepithelial neoplasia might prevent anal cancer. Screening programmes should meet the Wilson and Jungner criteria. We used these criteria to evaluate the current body of evidence supporting a screening programme for anal dysplasia...
November 10, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27806411/anal-chromoendoscopy-using-gastroenterological-video-endoscopes-a-new-method-to-perform-high-resolution-anoscopy-for-diagnosing-intraepithelial-neoplasia-and-anal-carcinoma-in-hiv-infected-patients
#3
M Oette, U Wieland, M Schünemann, J Haes, S Reuter, B Jensen, A Sagir, H Pfister, D Häussinger
Introduction: Anal carcinoma represents an increasing problem in HIV-infected patients. Anal intraepithelial neoplasia (AIN), the precursor lesion, is currently diagnosed by high-resolution anoscopy (HRA) using optical magnification derived from gynecological colposcopy. This prospective study evaluates anal chromoendoscopy (ACE) using standard gastroenterological video-endoscopes in diagnosing AIN. Methods: After clinical examination, proctoscopy and surface staining with acetic acid followed by Lugol's solution, ACE was performed with a mucosectomy cap on the tip of the endoscope...
November 2, 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27772624/human-papillomavirus-in-kidney-transplant-recipients
#4
REVIEW
Peter V Chin-Hong
Human papillomavirus (HPV) is a common infection in kidney transplant recipients. HPV causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. Kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. Given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN) most HPV-cancers are preventable with screening and targeted treatment of disease. Pre-transplant vaccination of age-eligible kidney transplant recipients is otherwise ideal...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27770248/a-trial-of-radiofrequency-ablation-for-anal-intraepithelial-neoplasia
#5
Robert N Goldstone, Shirin R Hasan, Steven Drury, Teresa M Darragh, Annemieke van Zante, Stephen E Goldstone
PURPOSE: Radiofrequency ablation (RFA) effectively treats esophageal high-grade dysplasia, but its efficacy in treating anal canal high-grade squamous intraepithelial lesions (HSILs) is unsubstantiated. This prospective study assessed the safety and efficacy of applying hemi-circumferential RFA to anal canal HSIL. METHODS: Twenty-one HIV-negative participants with HSIL occupying ≤ half the anal canal circumference were treated with hemi-circumferential anal canal RFA...
October 21, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27749636/anal-intraepithelial-neoplasia
#6
Michele Limoges-Gonzalez, Amar Al-Juburi
Anal squamous cell cancer (SCC) is a relatively uncommon cancer in the United States. Anal SCC has long been associated with human immunodeficiency virus (HIV) positivity and/or men who have sex with men. The incidence of anal SCC has been increasing in both genders regardless of HIV status. Few clinicians are aware that white women, when not controlling for gender and sexual preference together, have the highest incidence of anal SCC. Anal intraepithelial neoplasia (AIN), dysplastic cells of the anal canal due to human papilloma virus infection, is believed to be the precursor to anal SCC...
October 4, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27708526/endoscopic-submucosal-dissection-for-anal-intraepithelial-neoplasia
#7
Junichi Miyazaki, Noriya Uedo, Zhao Liang Li, Shohei Matsuo
No abstract text is available yet for this article.
October 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/27618320/tumors-and-tumorlike-conditions-of-the-anal-canal-and-perianal-region-mr-imaging-findings
#8
Venkateswar R Surabhi, Christine O Menias, Ahmed M Amer, Mohamed Elshikh, Venkata S Katabathina, Amy K Hara, William C Baughman, Ania Kielar, Khaled M Elsayes, Cary L Siegel
Tumors and tumorlike conditions of the anus and perianal region originate from the anal canal and anal margin or result from direct extension of tumors from adjacent organs. The anatomy of the anal canal is complex, and its different histologic characteristics can lead to diverse pathologic conditions. The anal canal extends from the anorectal junction to the anal verge. The World Health Organization classification of anal canal tumors includes (a) anal intraepithelial neoplasia, the precursor of squamous cell carcinoma (SCC), and (b) invasive tumors...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27600328/screening-for-anal-intraepithelial-neoplasia-high-resolution-anoscopy-guided-biopsy-of-the-anal-canal
#9
J B Repiso Jiménez, L Padilla España, T Fernández Morano, M de Troya Martín
No abstract text is available yet for this article.
September 3, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27561134/2016-ians-international-guidelines-for-practice-standards-in-the-detection-of-anal-cancer-precursors
#10
Richard John Hillman, Tamzin Cuming, Teresa Darragh, Mayura Nathan, Michael Berry-Lawthorn, Stephen Goldstone, Carmella Law, Joel Palefsky, Luis F Barroso, Elizabeth A Stier, Céline Bouchard, Justine Almada, Naomi Jay
OBJECTIVES: To define minimum standards for provision of services and clinical practice in the investigation of anal cancer precursors. METHODS: After initial face to face meetings of experts at the International Papillomavirus meeting in Lisbon, September 17 to 21, 2015, a first version was drafted and sent to key stakeholders. A complete draft was reviewed by the Board of the International Anal Neoplasia Society (IANS) and uploaded to the IANS Web site for all members to provide comments...
October 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27507125/-early-diagnosis-of-anal-intraepithelial-neoplasia-associated-with-human-papillomavirus-what-is-the-best-strategy
#11
Joaquin Burgos, Adrian Curran
No abstract text is available yet for this article.
August 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27505112/progression-from-perianal-high-grade-anal-intraepithelial-neoplasia-to-anal-cancer-in-hiv-positive-men-who-have-sex-with-men
#12
Jill Tinmouth, Valentina Peeva, Henok Amare, Sandra Blitz, Janet Raboud, Marie Sano, Leah Steele, Irving E Salit
BACKGROUND: High-grade intraepithelial neoplasia is known to progress to invasive squamous-cell carcinoma of the anus. There are limited reports on the rate of progression from high-grade intraepithelial neoplasia to anal cancer in HIV-positive men who have sex with men. OBJECTIVES: The purpose of this study was to describe in HIV-positive men who have sex with men with perianal high-grade intraepithelial neoplasia the rate of progression to anal cancer and the factors associated with that progression...
September 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27358257/long-term-risk-for-noncervical-anogenital-cancer-in-women-with-previously-diagnosed-high-grade-cervical-intraepithelial-neoplasia-a-danish-nationwide-cohort-study
#13
Freja Lærke Sand, Christian Munk, Signe Marie Jensen, Malene Frøsig Svahn, Kirsten Frederiksen, Susanne K Kjær
BACKGROUND: High-risk human papillomavirus (HPV) is essential for developing high-grade cervical intraepithelial neoplasia (CIN2 and CIN3) and has also been associated with noncervical anogenital cancers. However, limited knowledge exists about the long-term risk for anal, vulvar, and vaginal cancer following CIN2 or CIN3 diagnosis. METHODS: In a nationwide cohort study, we followed nearly 2.8 million women born in 1918-1990 who were recorded as living in Denmark between January 1, 1978 and December 31, 2012...
July 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27297278/evaluation-of-cervical-and-anal-intraepithelial-neoplasia-in-women-attending-a-sexually-transmitted-infection-clinic
#14
Kavita Bisherwal, Deepika Pandhi, Archana Singal, Kiran Guleria, Kiran Mishra
BACKGROUND: The incidence of anal and cervical cancers and their precursors have increased in the past decades. Women with HIV and sexually transmitted infections are at a higher risk. Cervical human papilloma virus infection may serve as a reservoir and source of anal infection or vice versa. A higher incidence of anal cytological abnormality has been observed in patients with abnormal cervical cytology. OBJECTIVES: This cross sectional study was designed to estimate the prevalence and associations of anal and cervical cytological abnormalities in a cohort of sexually active women using Papanicolaou smears...
September 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27152637/the-potential-impact-of-prophylactic-human-papillomavirus-vaccination-on-oropharyngeal-cancer
#15
REVIEW
Theresa Guo, David W Eisele, Carole Fakhry
The incidence of oropharyngeal cancer (OPC) is significantly increasing in the United States. Given that these epidemiologic trends are driven by human papillomavirus (HPV), the potential impact of prophylactic HPV vaccines on the prevention of OPC is of interest. The primary evidence supporting the approval of current prophylactic HPV vaccines is from large phase 3 clinical trials focused on the prevention of genital disease (cervical and anal cancer, as well as genital warts). These trials reported vaccine efficacy rates of 89% to 98% for the prevention of both premalignant lesions and persistent genital infections...
August 1, 2016: Cancer
https://www.readbyqxmd.com/read/27149102/secretory-leukocyte-protease-inhibitor-expression-and-high-risk-hpv-infection-in-anal-lesions-of-hiv-positive-patients
#16
Alcina F Nicol, Laurie L Brunette, Gerard J Nuovo, Beatriz Grinsztejn, Ruth K Friedman, Valdiléa G Veloso, Cynthia B Cunha, José R Coutinho, Cecilia Vianna de Andrade, Nathalia S Oliveira, Andrew W Woodham, Diane M Da Silva, W Martin Kast
OBJECTIVE: The aim of this study was to evaluate secretory leukocyte protease inhibitor (SLPI) expression in anal biopsies from HIV-positive (HIV+) individuals, and compare that to anal intraepithelial neoplasia (AIN) diagnoses and human papillomavirus (HPV) status. DESIGN: This is a cross-sectional study of a cohort of 54 HIV+ (31 males and 23 females) from an AIDS clinic in Rio de Janeiro, Brazil. METHODS: The study material consisted of anorectal tissue biopsies obtained from HIV+ subjects, which were used to construct tissue microarray paraffin blocks for immunohistochemical analysis of SLPI expression...
September 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27103359/high-grade-anal-intraepithelial-neoplasia-progression-to-invasive-cancer-is-not-a-certainty
#17
Mathilde Gautier, Charlène Brochard, Annie Lion, Sébastien Henno, Anne Laure Mallet, Anaïs Bodere, Guillaume Bouguen, Astrid Lièvre, Laurent Siproudhis
BACKGROUND: The incidences of high-grade anal intraepithelial neoplasia (HSIL) and superficially invasive squamous cell carcinomas (SISCCA) related to human papillomavirus (HPV) have increased. These lesions can progress to invasive anal cancer. The aim of the study was to assess the clinical outcome with a special focus on the healing rate. METHODS: Forty-six consecutive patients (M/F: 35/11; HIV+: 30) with histologically proven HSIL lesions (N=41) or SISCCA (N=5) were enrolled in a follow-up survey...
July 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27095188/evaluation-of-anal-cytology-and-dysplasia-in-women-with-a-history-of-lower-genital-tract-dysplasia-and-malignancy
#18
Beth Cronin, Amy Bregar, Christine Luis, Steven Schechter, Paul Disilvestro, Latha Pisharodi, C James Sung, Christina Raker, Melissa Clark, Katina Robison
OBJECTIVE: To compare the prevalence of abnormal anal cytology, high-risk anal HPV and biopsy proven anal dysplasia among women with a history of lower genital tract malignancy compared to those with dysplasia. METHODS: A prospective cohort study was performed from December 2012 to February 2014 at outpatient clinics at an academic medical center. Women with a history of high-grade cervical, vulvar, or vaginal dysplasia, or malignancy were recruited. Anal cytology and HPV genotyping were performed...
June 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/26994411/low-and-high-risk-human-papillomavirus-genotype-infections-in-intra-anal-warts-in-hiv-positive-men-who-have-sex-with-men
#19
M L Siegenbeek van Heukelom, O Richel, H J C de Vries, M M van de Sandt, S Beck, H A M van den Munckhof, E C Pirog, M N C de Koning, J M Prins, K D Quint
BACKGROUND: Anogenital warts are often presumed to represent nondysplastic or low-grade anal intraepithelial neoplasia (LGAIN). We previously demonstrated that up to 20% of intra-anal warts in HIV-positive men who have sex with men (MSM) contain regions of high-grade AIN (HGAIN). OBJECTIVES: To determine the causative human papillomavirus (HPV) types of low- and high- grade dysplastic areas in warts from HIV-positive MSM. METHODS: A total of 42 intra-anal warts from 41 HIV-positive MSM were graded as nondysplastic, LGAIN or HGAIN...
October 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26976378/-effectiveness-of-human-papillomavirus-genotyping-for-detection-of-high-grade-anal-intraepithelial-neoplasia-compared-to-anal-cytology
#20
Laura Padilla-España, Juan Bosco Repiso-Jiménez, Fernando Fernández-Sánchez, Teresa Pereda, Francisco Rivas-Ruiz, Teresa Fernández-Morano, Javier de la Torre-Lima, Fermín Palma, Maximino Redondo, Magdalena de Troya-Martín
INTRODUCTION: The incidence of high-grade anal intraepithelial neoplasia (HGAIN) -with an aetiological based on high-risk types of human papillomavirus- is increasing in some high-risk groups. Screening for HGAIN includes routine anal cytology and, more recently, HPV genotyping. The main objective of this study was to determine the sensitivity and specificity of anal cytology and HPV genotyping for the detection of HGAIN. MATERIALS AND METHODS: This is a study to determine the correlation of cytological and microbiological findings with anal biopsy findings in a cohort of patients at high risk of developing AIN referred to the department of sexually transmitted infections of the Hospital Costa del Sol, Spain, between January 2008 and December 2014...
August 2016: Enfermedades Infecciosas y Microbiología Clínica
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