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homosexuality genes

Mengyan Zhang, Ruolei Xin, Wenhui Chang
Many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) of HIV-1 have been found in men who have sex with men (MSM) in recent years, in China. In this study, a unique HIV-1 recombinant genome (SN153) was characterized from an HIV-positive male infected through homosexual behavior in Shaanxi, China. The mosaic pattern had a complex intersubtype recombinant structure with six breakpoints, with three subtype C segments inserted into subtype B backbone. And three similar breakpoints with CRF07_BC were observed in the pol gene...
February 14, 2018: AIDS Research and Human Retroviruses
Youlian Zhou, Zhitao Ou, Xiaoping Tang, Yongjian Zhou, Haoming Xu, Xianfei Wang, Kang Li, Jie He, Yanlei Du, Hong Wang, Ye Chen, Yuqiang Nie
Acquired immune deficiency syndrome (AIDS), caused by infection with human immunodeficiency virus (HIV), is associated with gastrointestinal disease, systemic immune activation and changes in the gut microbiota. Here, we aim to investigate the gut microbiota patterns of HIV-infected individuals and HIV-uninfected individuals in populations from South China. We enrolled 33 patients with HIV (14 participants treated with highly active antiretroviral therapy [HAART] for more than 3 months; the remaining 19 individuals had not received treatment) and 35 healthy controls (HC) for a cross-sectional comparison of gut microbiota using stool samples...
February 7, 2018: Journal of Cellular and Molecular Medicine
J F Zhang, J M Yao, Q Fan, W J Chen, X H Pan, X B Ding, J Z Yang, T Fu
Objective: To understand the characteristics of distribution on HIV-1 subtypes and the transmission clusters in Yiwu in Zhejiang province. Methods: A cross-sectional study of molecular epidemiology was carried out on newly reported HIV/AIDS cases in Yiwu. RNA was extracted from 168 plasma samples, followed by RT-PCR and nest-PCR for pol gene amplification, sequencing, phylogenetic tree construction used for analyzing the subtypes and transmission clusters. Mutations on drug resistance was analyzed by CPR 6...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Jia-Bi Qin, Guang-Lu Zhao, Feng Wang, Yu-Mao Cai, Li-Na Lan, Lin Yang, Tie-Jian Feng
BACKGROUND: Although it is widely acknowledged that genetic and environmental factors are involved in the development of male homosexuality, the causes are not fully understood. AIM: To explore the association and interaction of childhood abuse experiences and genetic variants of the catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR) genes with the development of male homosexuality. METHODS: A case-control study of 537 exclusively homosexual men and 583 exclusively heterosexual men was conducted, with data collected from March 2013 to August 2015...
January 2018: Journal of Sexual Medicine
Alan R Sanders, Gary W Beecham, Shengru Guo, Khytam Dawood, Gerulf Rieger, Judith A Badner, Elliot S Gershon, Ritesha S Krishnappa, Alana B Kolundzija, Jubao Duan, Pablo V Gejman, J Michael Bailey, Eden R Martin
Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men using Affymetrix single nucleotide polymorphism (SNP) arrays. We identified several SNPs with p < 10-5 , including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10-7 ) and 14 (p = 4.7 × 10-7 ). The genes nearest to these peaks have functions plausibly relevant to the development of sexual orientation...
December 7, 2017: Scientific Reports
Chen Wang, Yan Wang, Desheng Kong, Ruolei Xin, Weisi Xu, Yi Feng, Yiming Shao, Liying Ma
Cocirculation of multiple subtypes in the same population contributes significantly to the emergence of recombinant viruses. BJ2015EU19, a novel CCR5-tropic human immunodeficiency virus (HIV)-1, second-generation recombinant virus, was isolated from a man who has sex with men in Beijing, China. Phylogenetic analysis of the near full-length genome showed that BJ2015EU19 consisted of seven fragments from CRF01_AE and CRF07_BC. There were six recombinant breakpoints in the pol, vpu, env, and nef genes of BJ2015EU19, which were different from the other circulating recombinant forms and unique recombinant forms (URFs)...
November 2017: AIDS Research and Human Retroviruses
Yan-Mei Jiao, Guang-Lei Chen, Wei-Jun Zhu, Hui-Huang Huang, Jun-Liang Fu, Wei-Wei Chen, Ming Shi, Tong Zhang, Hao Wu, Fu-Sheng Wang
To date, there have been no reports characterizing HIV-1 in the semen of Chinese men who have sex with men (MSM) with early infection. In this study, genetic diversity and viral load of HIV-1 in the seminal compartments and blood of Chinese MSM with early HIV-1 infection were examined. Viral load and genetic diversity of HIV-1 in paired samples of semen and blood were analyzed in seven MSM with early HIV-1 infection. HIV-1 RNA and DNA were quantitated by real-time PCR assays. Through sequencing the C2-V5 region of the HIV-1 env gene, the HIV-1 genotype and genetic diversity based on V3 loop amino acid sequences were determined by using Geno2pheno and PSSM programs co-receptor usage...
June 2017: Microbiology and Immunology
Fan Li, Liying Ma, Yi Feng, Jing Hu, Na Ni, Yuhua Ruan, Yiming Shao
HIV-1 transmission in intravenous drug users (IDUs) has been characterized by high genetic multiplicity and suggests a greater challenge for HIV-1 infection blocking. We investigated a total of 749 sequences of full-length gp160 gene obtained by single genome sequencing (SGS) from 22 HIV-1 early infected IDUs in Xinjiang province, northwest China, and generated a transmitted and founder virus (T/F virus) consensus sequence (IDU.CON). The T/F virus was classified as subtype CRF07_BC and predicted to be CCR5-tropic virus...
June 2017: AIDS Research and Human Retroviruses
Xinli Lu, Cuiying Zhao, Wei Wang, Chenxi Nie, Yuqi Zhang, Hongru Zhao, Suliang Chen, Ze Cui
BACKGROUND: Since the first HIV-1 case in 1989, Hebei province has presented a clearly rising trend of HIV-1 prevalence, and HIV-1 genetic diversity has become the vital barrier to HIV prevention and control in this area. To obtain detailed information of HIV-1 spread in different populations and in different areas of Hebei, a cross-sectional HIV-1 molecular epidemiological investigation was performed across the province. METHODS: Blood samples of 154 newly diagnosed HIV-1 individuals were collected from ten prefectures in Hebei using stratified sampling...
January 19, 2016: AIDS Research and Therapy
Qiuyan Li, Yuandong Qiao, Guangfa Zhang, Ning He, Xuelong Zhang, Xueyuan Jia, Haiming Sun, Chuntao Wang, Lidan Xu
Men who have sex with men (MSM) are at high risk of HIV infection. The APOBEC3G (apolipoprotein B mRNA editing catalytic polypeptide 3G) protein is a component of innate antiviral immunity that inhibits HIV-1 replication. In the present study, a total of 483 HIV-1 seropositive men and 493 HIV-1 seronegative men were selected to investigate the association between single nucleotide polymorphisms (SNPs) of the APOBEC3G gene and susceptibility to HIV-1 infection and AIDS progression among MSM residing in northern China...
January 2017: Archives of Virology
Walter Geoffrey Roper
This hypothesis clearly proposes the true and previously undiscovered cause of male homosexuality or bisexuality and in most cases the predictability in infancy of the development of this sexuality in adulthood. It is based on compelling new evidence which has accumulated over many years. The fetal and neonatal periods are of the utmost importance in human development because they encompass critical periods which must be adhered to, for normal development. Biological variations may occur during these times, without implying the process of disease...
September 2016: Medical Hypotheses
Dan Tu, Ruiwei Xu, Guanglu Zhao, Binbin Wang, Tiejian Feng
Sexual orientation is influenced by both environmental factors and biological factors. Family and twin studies have shown that genetic factors play an important role in the formation of male homosexuality. Genome-wide scan also revealed candidate chromosomal regions which may be associated with male homosexuality, but so far no clearly related genes have been found. This article reviews the progress of relevant studies and candidate genes which are related to male homosexuality.
August 2016: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Giorgi Chaladze
Homosexuality has been documented throughout history and is found in almost all human cultures. Twin studies suggest that homosexuality is to some extent heritable. However, from an evolutionary perspective, this poses a problem: Male homosexuals tend to have on average five times fewer children than heterosexual males, so how can a phenomenon associated with low reproductive success be maintained at relatively stable frequencies? Recent findings of increased maternal fecundity of male homosexuals suggest that the genes responsible for homosexuality in males increase fecundity in the females who carry them...
October 2016: Archives of Sexual Behavior
Marina Pedroso Oliveira, Pollyanne Sousa Lemes, Márcia Alves Dias Matos, Nativa Helena Alves Del-Rios, Megmar Aparecida Santos Carneiro, Ágabo Macedo Costa Silva, Carmen Luci Rodrigues Lopes, Sheila Araújo Teles, Rodrigo Sebba Aires, Bárbara Vieira Lago, Natalia Motta Araujo, Regina Maria Bringel Martins
Although hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection is common, only few data are available on HBV among HIV patients including occult hepatitis B infection (OBI), regardless of serological markers. This study aims to determine the prevalence of OBI and overall HBV infection, associated factors, HBV genotypes, and surface (S) gene mutations in a population of treatment-naïve HIV-infected patients in Brazil. A cross-sectional study was conducted in treatment-naïve HIV-infected patients in Central Brazil...
July 2016: Journal of Medical Virology
Maria Elena Tosti, Valeria Alfonsi, Eleonora Lacorte, Alfonso Mele, Cristina Galli, Alessandro Remo Zanetti, Luisa Romanò
BACKGROUND: Hepatitis B vaccination has proven to be very safe and highly effective. This study assessed the proportion of successfully vaccinated individuals among cases with acute hepatitis B, the proportion of preventable cases if individuals were vaccinated as recommended, and the reasons for failures. METHODS: We analyzed data reported to the Italian Surveillance System for Acute Viral Hepatitis from 1993 to 2014. RESULTS: A total of 362 of 11 311 (3...
June 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Xinli Lu, Cuiying Zhao, Wei Wang, Chenxi Nie, Yuqi Zhang, Hongru Zhao, Suliang Chen, Ze Cui
BACKGROUND: Since the first HIV-1 case in 1989, Hebei province has presented a clearly rising trend of HIV-1 prevalence, and HIV-1 genetic diversity has become the vital barrier to HIV prevention and control in this area. To obtain detailed information of HIV-1 spread in different populations and in different areas of Hebei, a cross-sectional HIV-1 molecular epidemiological investigation was performed across the province. METHODS: Blood samples of 154 newly diagnosed HIV-1 individuals were collected from ten prefectures in Hebei using stratified sampling...
2016: AIDS Research and Therapy
Wei Yu, Dan Tu, Fuchang Hong, Jing Wang, Xiaoli Liu, Yumao Cai, Ruiwei Xu, Guanglu Zhao, Feng Wang, Hong Pan, Shinan Wu, Tiejian Feng, Binbin Wang
INTRODUCTION: Male sexual orientation is thought to have a genetic component. However, previous studies have failed to generate positive results from among candidate genes. Catechol-O-methyltransferase (COMT), located on chromosome 22, has six exons, spans 27 kb, and encodes a protein of 271 amino acids. COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens. COMT is also thought to be related to sexual orientation...
September 2015: Journal of Sexual Medicine
Ali Vahidnia, Pieter Jan van Empel, Sandra Costa, Rob T N Oud, Tahar van der Straaten, Harry Bliekendaal, Joke Spaargaren
A 53-year-old homosexual man presented at his general practitioner (GP) practice with a suspicion of sexually transmitted infection. Initial NAAT screening was performed for Chlamydia trachomatis and Neisseria gonorrhoeae. The patient was positive for Neisseria gonorrhoeae both for his urine and rectal sample. The subsequent confirmation test for Neisseria gonorrhoeae by a second laboratory was only confirmed for the urine sample and the rectal sample was negative. We report a case of a potential false-negative diagnosis of Neisseria gonorrhoeae due to mutations of DNA sequence in the probe region of opa-MGB assay of the rectal sample...
July 2015: New Microbiologica
Li-Juan Hou, Hong-Wei Wang, Shu-Peng Duan, Ya Zhuo, Yan-Cai Zhou, Hong-Jie Wu, Bao-Sheng Shen
To estimate the prevalence of human immunodeficiency virus (HIV) drug resistance (DR) in a population of men who have sex with men (MSM) from Henan Province of China and to identify the DR-associated HIV-1 mutations in these MSM. The HIV-positive status of the MSM subjects in this study was confirmed using ELISA and Western blotting. The MSM subjects were classified into non-treatment group (n = 106) and treatment group (n = 313). CD4(+) T-lymphocyte counts were obtained by flow cytometry, and viral load was measured by branched DNA (bDNA) signal amplification assay...
August 2015: Archives of Virology
Zheng Li, Jia Li, Yi Feng, Marcia L Kalish, Hongyan Lu, Lu Yin, Lingjie Liao, Han-Zhu Qian, Simon D W Frost, Yuhua Ruan, Sten H Vermund, Yiming Shao, Hui Xing
We report here two novel HIV-1 recombinant forms (CRF01_AE/B) isolated from two HIV-positive male subjects infected through homosexual contact in Beijing, China. Recombination contributes substantially to the genetic diversity of HIV-1, and is likely to occur in populations in which multiple subtypes circulate. Molecular epidemiological studies showed that subtype B, CRF01_AE, and CRF07_BC are currently cocirculating in parallel among men who have sex with men (MSM) in China, providing the opportunity for the emergence of new recombinants...
September 2015: AIDS Research and Human Retroviruses
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