keyword
https://read.qxmd.com/read/36998906/metabolomic-analysis-of-the-effects-of-a-mixed-culture-of-saccharomyces-cerevisiae-and-lactiplantibacillus-plantarum-on-the-physicochemical-and-quality-characteristics-of-apple-cider-vinegar
#21
JOURNAL ARTICLE
Ya-Nan Li, Yue Luo, Zhen-Ming Lu, Yan-Lin Dong, Li-Juan Chai, Jin-Song Shi, Xiao-Juan Zhang, Zheng-Hong Xu
INTRODUCTION: This study compared differences in physicochemical characteristics of the vinegar made by a mixed culture (MC) of Saccharomyces cerevisiae and Lactiplantibacillus plantarum and a pure culture (PC) of Saccharomyces cerevisiae . METHODS: The fermentation process was monitored, and metabolomics analysis by Liquid Chromagraphy-Mass Spectrometry (LC-MS) was applied to the compositional differences between PC and MC vinegars, combined with quantification of organic acids, amino acids and B vitamins...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/36894321/glycolytic-system-in-axons-supplement-decreased-atp-levels-after-axotomy-of-the-peripheral-nerve
#22
JOURNAL ARTICLE
Tomofumi Takenaka, Yuichiro Ohnishi, Masamichi Yamamoto, Daiki Setoyama, Haruhiko Kishima
Wallerian Degeneration (WD) occurs in the early stages of numerous neurological disorders, and clarifying WD pathology is crucial for the advancement of neurological therapies. Adenosine triphosphate (ATP) is acknowledged as one of the key pathological substances in WD. The ATP-related pathological pathways that regulate WD have been defined. The elevation of ATP levels in axon contributes to delay WD and protects axons. While, ATP is necessary for the active processes to proceed WD, given that WD is stringently managed by auto-destruction programs...
March 9, 2023: ENeuro
https://read.qxmd.com/read/36857499/tubular-epithelial-cell-hmgb1-promotes-aki-ckd-transition-by-sensitizing-cycling-tubular-cells-to-oxidative-stress-a-rationale-for-targeting-hmgb1-during-aki-recovery
#23
JOURNAL ARTICLE
Zhi Bo Zhao, Julian A Marschner, Takamasa Iwakura, Chenyu Li, Manga Motrapu, Meisi Kuang, Bastian Popper, Andreas Linkermann, Jan Klocke, Philipp Enghard, Yoshiharu Muto, Benjamin D Humphreys, Helena Erlandsson Harris, Paola Romagnani, Hans-Joachim Anders
SIGNIFICANCE STATEMENT: Cells undergoing necrosis release extracellular high mobility group box (HMGB)-1, which triggers sterile inflammation upon AKI in mice. Neither deletion of HMGB1 from tubular epithelial cells, nor HMGB1 antagonism with small molecules, affects initial ischemic tubular necrosis and immediate GFR loss upon unilateral ischemia/reperfusion injury (IRI). On the contrary, tubular cell-specific HMGB1 deficiency, and even late-onset pharmacological HMGB1 inhibition, increased functional and structural recovery from AKI, indicating that intracellular HMGB1 partially counters the effects of extracellular HMGB1...
March 1, 2023: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/36842318/design-synthesis-antimicrobial-screening-and-molecular-modeling-of-novel-6-7-dimethylquinoxalin-2-1h-one-and-thiazole-derivatives-targeting-dna-gyrase-enzyme
#24
JOURNAL ARTICLE
Raghad M Alqurashi, Thoraya A Farghaly, Rehab Sabour, Mohamed R Shaabana
New 6,7-dimethylquinoxalin-2(1H)-one and hydrazineylidene thiazol-4-one derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The obtained results revealed marked antimicrobial potential against four bacterial, and two fungal strains. Both 6,7-dimethyl-3-(2-(4-nitrophenyl)-2-oxoethyl)quinoxalin-2(1H)-one (4d), and 2-(2-(9H-fluoren-9-ylidene)hydrazineyl)-5-(2-(p-tolyl)hydrazineylidene)thiazol-4(5H)-one (11b) displayed significant antibacterial and antifungal activities having MIC ranges (1...
February 21, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/36818166/isolation-characterization-and-docking-studies-of-campesterol-and-%C3%AE-sitosterol-from-strychnos-innocua-delile-root-bark
#25
JOURNAL ARTICLE
Ahmed Jibrin Uttu, Muhammad Sani Sallau, Hamisu Ibrahim, Ogunkemi Risikat Agbeke Iyun
OBJECTIVES: Phytosterols obtained from medicinal plants are well known for their anti-diabetic, anti-cardiovascular, anti-cancer, and anti-microbial properties. Strychnos innocua (a member of the Loganiaceae family) grows in several African nations and is frequently used for medicinal purposes. METHODS: The chromatographic separation of S. innocua (root bark) ethyl acetate extract resulted in the isolation of campesterol ( 1 ) and β-sitosterol ( 2 ). RESULTS: The structures of 1 and 2 were confirmed by mass spectrometry, nuclear magnetic resonance (1D and 2D NMR), and literature data...
June 2023: Journal of Taibah University Medical Sciences
https://read.qxmd.com/read/36795720/ethyl-pyruvate-protects-shsy5y-cells-against-6-hydroxydopamine-induced-neurotoxicity-by-upregulating-autophagy
#26
JOURNAL ARTICLE
Yuening Luo, Kazuichi Sakamoto
Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a pyruvic acid derivative, on 6-hydroxydopamine-induced SH-SY5Y cell apoptosis. Ethyl pyruvate decreased protein levels of cleaved caspase-3, phosphorylated endoplasmic reticulum kinase (pERK), and extracellular signal-regulated kinase (ERK), suggesting that EP reduces apoptosis via the ERK signaling pathway...
2023: PloS One
https://read.qxmd.com/read/36379005/catalyst-free-aqueous-hyperpolarized-1-13-c-pyruvate-obtained-by-re-dissolution-signal-amplification-by-reversible-exchange
#27
JOURNAL ARTICLE
Andreas B Schmidt, Henri de Maissin, Isaiah Adelabu, Shiraz Nantogma, Jessica Ettedgui, Patrick TomHon, Boyd M Goodson, Thomas Theis, Eduard Y Chekmenev
Despite great successes in oncology, patient outcomes are often still discouraging, and hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of the pathology to better understand individual disease biology and to personalize therapies. The dissolution Dynamic Nuclear Polarization (d-DNP) hyperpolarization method has enabled unprecedented real-time MRI sensing of metabolism and tissue pH using hyperpolarized [1-13 C]pyruvate as a biosensor with great potential for diagnosis and monitoring of cancer patients...
November 15, 2022: ACS Sensors
https://read.qxmd.com/read/36371512/parahydrogen-induced-polarization-and-spin-order-transfer-in-ethyl-pyruvate-at-high-magnetic-fields
#28
JOURNAL ARTICLE
Andrey N Pravdivtsev, Arne Brahms, Frowin Ellermann, Tim Stamp, Rainer Herges, Jan-Bernd Hövener
Nuclear magnetic resonance has experienced great advances in developing and translating hyperpolarization methods into procedures for fundamental and clinical studies. Here, we propose the use of a wide-bore NMR for large-scale (volume- and concentration-wise) production of hyperpolarized media using parahydrogen-induced polarization. We discuss the benefits of radio frequency-induced parahydrogen spin order transfer, we show that 100% polarization is theoretically expected for homogeneous B0 and B1 magnetic fields for a three-spin system...
November 12, 2022: Scientific Reports
https://read.qxmd.com/read/36187352/protective-role-of-ethyl-pyruvate-in-spinal-cord-injury-by-inhibiting-the-high-mobility-group-box-1-toll-like-receptor4-nuclear-factor-kappa-b-signaling-pathway
#29
REVIEW
Ruihua Fan, Lvxia Wang, Benson O A Botchway, Yong Zhang, Xuehong Liu
Spinal cord injury (SCI) is a high incident rate of central nervous system disease that usually causes paralysis below the injured level. The occurrence of chronic inflammation with the axonal regeneration difficulties are the underlying barriers for the recovery of SCI patients. Current studies have paid attention to controlling the instigative and developmental process of neuro-inflammation. Ethyl pyruvate, as a derivative of pyruvate, has strong anti-inflammatory and neuroprotective functions. Herein, we reviewed the recent studies of ethyl pyruvate and high mobility group box-1 (HMGB1)...
2022: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36177925/-mechanism-of-high-mobility-group-protein-b1-in-lipopolysaccharide-induced-acute-lung-injury-acute-respiratory-distress-syndrome
#30
JOURNAL ARTICLE
Jianyu Qu, Jiali Feng, Jun Li, Xiao Huang, Boyang Qi, Tiantian Qian, Xiaozhi Wang
OBJECTIVE: To investigate the role and possible pathogenesis of high mobility group protein B1 (HMGB1) in lipopolysaccharide (LPS)-induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). METHODS: (1) In vivo, 24 SPFC57BL/6 male mice were randomly divided into normal control group, ALI/ARDS model group, ethyl pyruvate (EP) treatment group and EP control group, with 6 mice in each group. The ALI/ARDS model was established by intraperitoneal injection of 20 mg/kg LPS...
August 2022: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/36157036/neuroprotective-and-antioxidant-activities-of-different-polarity-parts-of-the-extracts-of-the-ginkgo-biloba-leaf-and-zingiber-officinale-rhizome-from-yongzhou
#31
JOURNAL ARTICLE
Zuoying Huang, Tingting Yuan, Jiayi Chen, Mihan Jiang, Rongling Yan, Wencai Yang, Liqian Wang, Yang Liao, Guowen Huang
In order to make better use of the two local dominant plant resources of Ginkgo biloba and Zingiber officinale from Yongzhou in Hunan province, the in vitro neuroprotective and antioxidant activities of extracts from the G. biloba leaf and Z. officinale rhizome, and the correlation between these two kinds of activities, were analyzed. The in vivo effects of these two plant extracts on aged mice blood physiology and central neuron cell activity were then determined after continuous gavage with the best polarity part at different concentrations (2, 4, 8 mg/ml)...
2022: Frontiers in Chemistry
https://read.qxmd.com/read/36139393/extracellular-hmgb1-as-inflammatory-mediator-in-the-progression-of-mycoplasma-gallisepticum-infection
#32
JOURNAL ARTICLE
Yingjie Wang, Lulu Wang, Fuli Hu, Mengyun Zou, Ronglong Luo, Yingfei Sun, Tengfei Wang, Qiao Guo, Xiuli Peng
High-mobility group box 1 (HMGB1), a member of damage-associated molecular patterns (DAMPs), is involved in the immune regulation of several infectious diseases. Mycoplasma gallisepticum (MG) infection is proved to cause an abnormal immune response, but the role of HMGB1 in MG-induced chronic respiratory disease (CRD) is unclear. In this study, we found that HMGB1 was released from the nucleus to the extracellular in macrophages upon infection with MG. Extracellular HMGB1 bound to TLR2 activating the NF-κB pathway triggering a severe inflammatory storm and promoting the progression of MG infection...
September 9, 2022: Cells
https://read.qxmd.com/read/36126784/liver-protection-and-hemostatic-effects-of-medicinal-plant-arnebia-euchroma-royle-i-m-johnst-extract-in-a-rat-model
#33
JOURNAL ARTICLE
Nuramatjan Ablat, Mihray Ablimit, Abudoureheman Abudoukadier, Buhaiqiemu Kadeer, Abulaitijiang Maihemuti, Alibati Bakewaiyi, Atike Tuerxun, Adilijiang Aihemaiti
ETHNOPHARMACOLOGICAL RELEVANCE: Arnebia euchroma (Royle) I.M.Johnst. (AE) is a Chinese medicinal herb that is traditionally used to treat various circulatory diseases. It exhibits certain effects, such as the promotion of blood circulation and cooling, rash clearance, and detoxification. AIM OF THE STUDY: This study was designed to explore the hepatoprotective and hemostatic effects of the ethyl acetate extract of AE in rats with carbon tetrachloride (CCl4)-induced liver injury...
September 17, 2022: Journal of Ethnopharmacology
https://read.qxmd.com/read/36088112/bioremediation-of-degraded-pit-mud-by-indigenous-microbes-for-baijiu-production
#34
JOURNAL ARTICLE
Mao-Ke Liu, Cheng-Yuan Liu, Xin-Hui Tian, Jun Feng, Xiao-Jiao Guo, Ying Liu, Xin-Yu Zhang, Yu-Ming Tang
Microbes in pit mud play key roles in fermentation cellars for Chinese strong-flavor Baijiu (SFB) production. Pit mud, however, is frequently degraded during production, compromising the quality of the end product. In this study, a bioremediation method was used to restore degraded pit mud (DPM) using indigenous microbes derived from SFB production. Metabolomics and metagenomics were used to determine the dynamics of prokaryotes during DPM restoration and their link to SFB production. The composition of flavor compounds in SFB changed (P = 0...
December 2022: Food Microbiology
https://read.qxmd.com/read/36045807/-cli-nical%C3%A2-p-rofile-and%C3%A2-s-ide%C3%A2-e-ffects-of-chronic-use-of-oral%C3%A2-a-miodarone-in-cardiology-outpatients-department-clipse-a-study-a-prospective-observational-study
#35
JOURNAL ARTICLE
Nabeela Fatima, Kiranmai Mandava, Fatima Khatoon, Juveria Badar, Syeda Fatima Begum, C Narasimhan, K Daljeet, Walli Mohammed
BACKGROUND: Amiodarone belongs to Class-III anti-arrhythmic drugs. It is one of the most effective anti-arrhythmic drugs used to treat or prevent several types of arrhythmias including atrial fibrillation, atrial flutter, ventricular tachycardia, and wide complex tachycardia, but unfortunately carries a high toxicity profile. Also, side effects of amiodarone involving various organs can be life-threatening. MATERIALS & METHODS: This was an observational study carried out for six months i...
August 2022: Annals of Medicine and Surgery
https://read.qxmd.com/read/36000773/efficacy-of-alternative-forms-of-creatine-supplementation-on-improving-performance-and-body-composition-in-healthy-subjects-a-systematic-review
#36
JOURNAL ARTICLE
Carly Fazio, Craig L Elder, Margaret M Harris
Fazio, C, Elder, CL, and Harris, MM. Efficacy of alternative forms of creatine supplementation on improving performance and body composition in healthy subjects: a systematic review. J Strength Cond Res 36(9): 2663-2670, 2022-Novel forms of creatine have appeared in the marketplace with substantial claims of improved efficacy compared to creatine monohydrate (CrM). The purpose of this study was to conduct a systematic review on alternative forms of creatine to determine (a) whether they are effective ergogenic aids and (b) whether they outperform CrM...
September 1, 2022: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/35795216/administration-of-phosphonate-inhibitors-of-dehydrogenases-of-2-oxoglutarate-and-2-oxoadipate-to-rats-elicits-target-specific-metabolic-and-physiological-responses
#37
JOURNAL ARTICLE
Victoria I Bunik, Artem V Artiukhov, Alexey V Kazantsev, Vasily A Aleshin, Alexandra I Boyko, Alexander L Ksenofontov, Nikolay V Lukashev, Anastasia V Graf
In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL ) and 2-oxoadipate (OADH, encoded by DHTKD1 ), respectively. To assess the selectivity in animals, the effects of SP, AP, and their membrane-penetrating triethyl esters (TESP and TEAP) on the rat brain metabolism and animal physiology are compared. Opposite effects of the OGDH and OADH inhibitors on activities of OGDH, malate dehydrogenase, glutamine synthetase, and levels of glutamate, lysine, citrulline, and carnosine are shown to result in distinct physiological responses...
2022: Frontiers in Chemistry
https://read.qxmd.com/read/35737477/mitochondria-targeting-polymer-micelle-of-dichloroacetate-induced-pyroptosis-to-enhance-osteosarcoma-immunotherapy
#38
JOURNAL ARTICLE
Jiakang Jin, Pengcheng Yuan, Wei Yu, Jinti Lin, Ankai Xu, Xiaodan Xu, Jianan Lou, Tao Yu, Chao Qian, Bing Liu, Jiashi Song, Lijun Li, Ying Piao, Tao Xie, Youqing Shen, Huimin Tao, Jianbin Tang
Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment and may be a strategy to enhance osteosarcoma treatment. The extent to which modulation of mitochondria could induce tumor pyroptosis to enhance immunotherapy has not been characterized. We synthesized a mitochondria-targeting polymer micelle (OPDEA-PDCA), in which poly[2-( N -oxide- N , N -diethylamino)ethyl methacrylate] (OPDEA) was used to target mitochondria and the conjugated dichloroacetate (DCA) was used to inhibit pyruvate dehydrogenase kinase 1 (PDHK1)...
June 23, 2022: ACS Nano
https://read.qxmd.com/read/35695514/endogenous-glutamine-is-rate-limiting-for-anti-cd3-and-anti-cd28-induced-cd4-t-cell-proliferation-and-glycolytic-activity-under-hypoxia-and-normoxia
#39
JOURNAL ARTICLE
Jonas A Wik, Azazul Chowdhury, Shrikant Kolan, Nasser E Bastani, Gaoyang Li, Kazi Alam, Franco Grimolizzi, Bjørn S Skålhegg
To meet the demand for energy and biomass, T lymphocytes (T cells) activated to proliferation and clonal expansion, require uptake and metabolism of glucose (Gluc) and the amino acid (AA) glutamine (Gln). Whereas exogenous Gln is converted to glutamate (Glu) by glutaminase (GLS), Gln is also synthesized from the endogenous pool of AA through Glu and activity of glutamine synthase (GS). Most of this knowledge comes from studies on cell cultures under ambient oxygen conditions (normoxia, 21% O2). However, in vivo, antigen induced T-cell activation often occurs under moderately hypoxic (1-4% O2) conditions and at various levels of exogenous nutrients...
June 17, 2022: Biochemical Journal
https://read.qxmd.com/read/35680823/-effect-of-anti-oxidative-of-ethyl-pyruvate-and-taurine-on-the-red-blood-cell-storage-at-4-%C3%A2
#40
JOURNAL ARTICLE
Shu-Qiang Gao, Shu-Hui Gao, Chen-Hui Zhu, Xiao-Yan Yuan, Li-Xia Ren
OBJECTIVE: To investigate the anti-oxidative effect of ethyl pyruvate (EP) and taurine (TAU) on the quality of red blood cells stored at 4±2 ℃, hemolysis, energy metabolism and lipid peroxidation of the red blood cells in the preservation solution were studied at different intervals. METHODS: At 4±2 ℃, the deleukocyte red blood cells were stored in the citrate-phosphate-dextrosesaline-adenine-1 (CPDA-1) preservation (control group), preservation solution with EP (EP-AS), and TAU (TAU-AS) for long-term preservation...
June 2022: Zhongguo Shi Yan Xue Ye Xue za Zhi
keyword
keyword
81483
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.