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Ethyl pyruvate

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https://www.readbyqxmd.com/read/29761062/glycosylceramide-modifies-the-flavor-and-metabolic-characteristics-of-sake-yeast
#1
Jannatul Ferdouse, Yuki Yamamoto, Seiga Taguchi, Yumiko Yoshizaki, Kazunori Takamine, Hiroshi Kitagaki
In the manufacture of sake, Japanese traditional rice wine, sake yeast is fermented with koji, which is steamed rice fermented with the non-pathogenic fungus Aspergillus oryzae . During fermentation, sake yeast requires lipids, such as unsaturated fatty acids and sterols, in addition to substances provided by koji enzymes for fermentation. However, the role of sphingolipids on the brewing characteristics of sake yeast has not been studied. In this study, we revealed that glycosylceramide, one of the sphingolipids abundant in koji, affects yeast fermentation...
2018: PeerJ
https://www.readbyqxmd.com/read/29725369/ethyl-pyruvate-can-alleviate-alcoholic-liver-disease-through-inhibiting-nrf2-signaling-pathway
#2
Fei Shen, Zhaohong Wang, Wei Liu, Yuji Liang
The effects of ethyl pyruvate (EP) on alcoholic liver disease and its related mechanism were investigated. Thirty male C57/BL6 mice were randomly divided to three groups: Control (n=10), alcoholic liver disease (ALD, n=10) and ethyl pyruvate group (EP, n=10). EP group was treated with gavage using EP (100 mg/kg) for 15 consecutive days. Control and ALD group were treated with the same volume of normal saline. After the last gavage, EP and ALD group were treated with the intraperitoneal injection of 50% alcoholic solution (10 ml/kg)...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29663989/-high-mobility-group-box-1-contributes-to-the-endoplasmic-reticulum-stress-of-liver-in-rats-with-trauma
#3
Qingjie Zhang, Jianfeng Lu, Xuehao Li, Yichang Liu, Guoqing Liu, Xinhua Han, Zhenyong Gu
OBJECTIVE: To investigate the role of high mobility group box 1 (HMGB1) in hepatic endoplasmic reticulum stress (ERS) in rats with trauma. METHODS: Sixty SPF Sprague-Dawley (SD) rats were randomly divided into groups (n = 6). The rat model of liver injury following traumatic stress was established by continuous compressing the bilateral hind-limbs of rats for 3 hours and then intermittent compressing and decompressing for 30 minutes respectively three times with standard weight of 15 kg...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29611132/modulation-of-diabetes-related-liver-injury-by-the-hmgb1-tlr4-inflammatory-pathway
#4
Sofija Jovanović Stojanov, Vesna Martinović, Desanka Bogojević, Goran Poznanović, Anja Petrović, Svetlana Ivanović-Matić, Ilijana Grigorov
Chronic inflammation plays an essential role in the development of diabetic complications. Understanding the molecular mechanisms that support inflammation is a prerequisite for the design of novel anti-inflammatory therapies. These would take into consideration circulating levels of cytokines and damage-associated molecular patterns (DAMPs) that include the high mobility group box 1 (HMGB1) protein which, in part, promotes the inflammatory response through TLR4 signaling. The liver, as the source of circulating cytokines and acute-phase proteins, contributes to the control of systemic inflammation...
April 2, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29560444/ethyl-pyruvate-attenuates-acetaminophen-induced-liver-injury-and-prevents-cellular-injury-induced-by-n-acetyl-p-benzoquinone-imine
#5
Minako Nagatome, Yuki Kondo, Daisuke Kadowaki, Yusuke Saishyo, Mitsuru Irikura, Tetsumi Irie, Yoichi Ishitsuka
Acetaminophen, a common analgesic/antipyretic, is a frequent cause of acute liver failure in Western countries. The development of an effective cure against acetaminophen hepatotoxicity is crucial. Ethyl pyruvate, an ethyl ester derivative of pyruvic acid, has been identified as a possible candidate against acetaminophen hepatotoxicity in animal experiments. However, the mode of the hepatoprotective action of ethyl pyruvate remains unclear. We examined the hepatoprotective effect of ethyl pyruvate against hepatocyte injury and oxidative stress in a mouse model of acetaminophen hepatotoxicity...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29534959/the-urinary-organic-acids-profile-in-single-large-scale-mitochondrial-dna-deletion-disorders
#6
Michela Semeraro, Sara Boenzi, Rosalba Carrozzo, Daria Diodato, Diego Martinelli, Giorgia Olivieri, Giacomo Antonetti, Elisa Sacchetti, Giulio Catesini, Cristiano Rizzo, Carlo Dionisi-Vici
Single large-scale mitochondrial DNA deletions disorders are classified into three main phenotypes with frequent clinical overlap: Pearson marrow-pancreas syndrome (PMS), Kearns-Sayre syndrome (KSS) and chronic progressive external ophtalmoplegia (PEO). So far, only few anecdotal studies have reported on the urinary organic acids profile in this disease class. In this single-center retrospective study, we performed quantitative evaluation of urinary organic acids in a series of 15 pediatric patients, 7 with PMS and 8 with KSS...
March 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29527403/highly-selective-oxidation-of-ethyl-lactate-to-ethyl-pyruvate-catalyzed-by-mesoporous-vanadia-titania
#7
Wei Zhang, Giada Innocenti, Paula Oulego, Vitaly Gitis, Haihong Wu, Bernd Ensing, Fabrizio Cavani, Gadi Rothenberg, N Raveendran Shiju
The direct oxidative dehydrogenation of lactates with molecular oxygen is a "greener" alternative for producing pyruvates. Here we report a one-pot synthesis of mesoporous vanadia-titania (VTN), acting as highly efficient and recyclable catalysts for the conversion of ethyl lactate to ethyl pyruvate. These VTN materials feature high surface areas, large pore volumes, and high densities of isolated vanadium species, which can expose the active sites and facilitate the mass transport. In comparison to homogeneous vanadium complexes and VO x /TiO2 prepared by impregnation, the meso-VTN catalysts showed superior activity, selectivity, and stability in the aerobic oxidation of ethyl lactate to ethyl pyruvate...
March 2, 2018: ACS Catalysis
https://www.readbyqxmd.com/read/29526883/ethyl-pyruvate-improves-pulmonary-function-in-mice-with-bleomycin-induced-lung-injury-as-monitored-with-hyperpolarized-129-xe-mr-imaging
#8
Shota Hodono, Akihiro Shimokawa, Neil J Stewart, Yukiko Yamauchi, Renya Nishimori, Mami Yamane, Hirohiko Imai, Hideaki Fujiwara, Atsuomi Kimura
PURPOSE: High Mobility Group Box1 (HMGB1), which is one of the damage-associated molecular pattern molecules relating to various inflammatory diseases, has gained interest as a therapeutic target because of its involvement in wound healing processes. In the present study, we investigated HMGB1 as a potential therapeutic target in a model of lung fibrosis using a preclinical hyperpolarized 129 Xe (HPXe) MRI system. METHODS: Lung injury was induced by intra-peritoneal injection of bleomycin (BLM) in 19 mice...
March 9, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29423860/schizosaccharomyces-pombe-biotechnological-applications-in-winemaking
#9
Ángel Benito, Fernando Calderón, Santiago Benito
The traditional way of producing wine is through the use of Saccharomyces cerevisiae in order to convert glucose and fructose into alcohol. In the case of red wines, after this alcoholic fermentation lactic bacteria Oenococus oeni is used to stabilize wine from a microbiological point of view by converting malic acid into lactic acid that it is not a microbiological substract. The yeast species Schizosaccharomyces pombe was traditionally considered spoilage yeast. Nevertheless, during the last decade it started to be used due to its unique malic acid deacidification ability to reduce the harsh acidity of wines from northern Europe, by converting malic acid to ethanol and CO2 without producing lactic acid as lactic bacteria does...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29420894/revealing-catalytically-relevant-surface-species-by-kinetic-isotope-effect-spectroscopy-h-bonding-to-ester-carbonyl-of-trans-ethyl-pyruvate-controls-enantioselectivity-on-a-cinchona-modified-pt-catalyst
#10
Fabian Meemken, Laura Rodríguez-García
Monitoring active surface species on an operating technical catalyst is a challenging task due to the presence of multiple different adsorption sites and the abundance of bulk species. In this work, kinetic isotope effect (KIE) spectroscopy is introduced to capture the signals of catalytically relevant hydrogenation species from the IR spectroscopic detection in attenuated total reflection mode. The catalytic interface formed between a cinchona-modified Pt/Al2 O3 catalyst and the solvent toluene is sensitively probed directly at the rate limiting step(s) during the asymmetric hydrogenation of ethyl pyruvate by measuring the effects of substituting H2 by D2 kinetically and spectroscopically in the same operando experiment...
March 1, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29420582/ethyl-pyruvate-ameliorates-hepatic-injury-following-blunt-chest-trauma-and-hemorrhagic-shock-by-reducing-local-inflammation-nf-kappab-activation-and-hmgb1-release
#11
Nils Wagner, Scott Dieteren, Niklas Franz, Kernt Köhler, Katharina Mörs, Luka Nicin, Julia Schmidt, Mario Perl, Ingo Marzi, Borna Relja
BACKGROUND: The treatment of patients with multiple trauma including blunt chest/thoracic trauma (TxT) and hemorrhagic shock (H) is still challenging. Numerous studies show detrimental consequences of TxT and HS resulting in strong inflammatory changes, organ injury and mortality. Additionally, the reperfusion (R) phase plays a key role in triggering inflammation and worsening outcome. Ethyl pyruvate (EP), a stable lipophilic ester, has anti-inflammatory properties. Here, the influence of EP on the inflammatory reaction and liver injury in a double hit model of TxT and H/R in rats was explored...
2018: PloS One
https://www.readbyqxmd.com/read/29370236/ethyl-pyruvate-inhibits-oxidation-of-ldl-in-vitro-and-attenuates-oxldl-toxicity-in-ea-hy926-cells
#12
Christine Rossmann, Christoph Nusshold, Margret Paar, Gerhard Ledinski, Erwin Tafeit, Martin Koestenberger, Eva Maria Bernhart, Wolfgang Sattler, Gerhard Cvirn, Seth Hallström
BACKGROUND: Ethyl pyruvate (EP) exerts anti-inflammatory and anti-oxidative properties. The aim of our study was to investigate whether EP is capable of inhibiting the oxidation of LDL, a crucial step in atherogenesis. Additionally, we examined whether EP attenuates the cytotoxic effects of highly oxidized LDL in the human vascular endothelial cell line EA.hy926. METHODS: Native LDL (nLDL) was oxidized using Cu2+ ions in the presence of increasing amounts of EP...
2018: PloS One
https://www.readbyqxmd.com/read/29355144/ethyl-pyruvate-improves-skin-flap-survival-after-ischaemia-reperfusion-injury
#13
Oguz Kayiran, Suat Sedat Cuzdan, Afsin Uysal, Ugur Kocer
BACKGROUND & OBJECTIVES: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. METHODS: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups)...
September 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29316268/crosstalk-between-hepatitis-b-virus-x-and-high-mobility-group-box-1-facilitates-autophagy-in-hepatocytes
#14
Sha Fu, Juan Wang, Xingwang Hu, Rong-Rong Zhou, Yongming Fu, Daolin Tang, Rui Kang, Yan Huang, Lunquan Sun, Ning Li, Xue-Gong Fan
Hepatitis B virus (HBV) X (HBx) protein is a pivotal regulator of HBV-triggered autophagy. However, the role of HBx-induced epigenetic changes in autophagy remains largely unknown. The cytoplasmic (Cyt) high-mobility group box 1 (HMGB1) has been identified as a positive regulator of autophagy, and its Cyt translocation is closely associated with its acetylation status. Here, we evaluated the function of HMGB1 in HBx-mediated autophagy and its association with histone deacetylase (HDAC). Using cell lines with enforced expression of HBx, we demonstrated that HBx upregulated the expression of HMGB1 and promoted its Cyt translocation by acetylation to facilitate autophagy...
March 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29259719/roles-of-nitric-oxide-and-ethyl-pyruvate-after-peripheral-nerve-injury
#15
REVIEW
Sandesh Panthi, Kripa Gautam
Short-lived reactive nitrogen species and reactive oxygen species have acquired significant attention in the field of biomedical science. Nitric oxide (NO), which was thought to be an unstable gas and pollutant, is now regarded as a gas transmitter like H2 S and CO. NO is synthesized inside the mammalian body by l-arginine via three different isoforms of NO synthase whereas pyruvate is a glycolysis product and substrate for TCA cycle. Due to poor solubility and stability, therapeutic potential of pyruvate is limited...
2017: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29195782/hmgb1-mediates-depressive-behavior-induced-by-chronic-stress-through-activating-the-kynurenine-pathway
#16
Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wang
Our previous study has reported that the proactive secretion and role of central high mobility group box 1 (HMGB1) in lipopolysaccharide-induced depressive behavior. Here, the potential mechanism of HMGB1 mediating chronic-stress-induced depression through the kynurenine pathway (KP) was further explored both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS). Sucrose preference and Barnes maze test were performed to reflect depressive behaviors. The ratio of kynurenine (KYN)/tryptophan (Trp) represented the enzyme activity of indoleamine-2,3-dioxygenase (IDO)...
November 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29195627/ethyl-pyruvate-is-renoprotective-against-ischemia-reperfusion-injury-under-hyperglycemia
#17
Ji Hae Jun, Jong Wook Song, Eun-Jung Shin, Young-Lan Kwak, Nakcheol Choi, Jae-Kwang Shim
BACKGROUND: Hyperglycemia (HG) is common in cardiovascular surgeries due to diabetes, inflammation, and the neuroendocrine stress response. HG aggravates renal ischemia-reperfusion (I/R) injury through an increased inflammatory response, and blunts the protective effect of various measures. Ethyl pyruvate (EP) provides anti-inflammatory effects against I/R injury via inhibition of high-mobility group box 1 protein (HMGB1) release. This study aimed to determine the renoprotective effect of EP against I/R injury under HG...
November 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29178911/inhibition-of-hmgb1-reduces-rat-spinal-cord-astrocytic-swelling-and-aqp4-expression-after-oxygen-glucose-deprivation-and-reoxygenation-via-tlr4-and-nf-%C3%AE%C2%BAb-signaling-in-an-il-6-dependent-manner
#18
Lin Sun, Man Li, Xun Ma, Haoyu Feng, Junlai Song, Cong Lv, Yajun He
BACKGROUND: Spinal cord astrocyte swelling is an important component to spinal cord edema and is associated with poor functional recovery as well as therapeutic resistance after spinal cord injury (SCI). High mobility group box-1 (HMGB1) is a mediator of inflammatory responses in the central nervous system and plays a critical role after SCI. Given this, we sought to identify both the role and underlying mechanisms of HMGB1 in cellular swelling and aquaporin 4 (AQP4) expression in cultured rat spinal cord astrocytes after oxygen-glucose deprivation/reoxygenation (OGD/R)...
November 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29176872/para-hydroxyphenylpyruvate-inhibits-the-pro-inflammatory-stimulation-of-macrophage-preventing-lps-mediated-nitro-oxidative-unbalance-and-immunometabolic-shift
#19
Rosella Scrima, Marta Menga, Consiglia Pacelli, Francesca Agriesti, Olga Cela, Claudia Piccoli, Antonella Cotoia, Alessandra De Gregorio, Julia V Gefter, Gilda Cinnella, Nazzareno Capitanio
Targeting metabolism is emerging as a promising therapeutic strategy for modulation of the immune response in human diseases. In the presented study we used the lipopolysaccharide (LPS)-mediated activation of RAW 264.7 macrophage-like cell line as a model to investigate changes in the metabolic phenotype and to test the effect of p-hydroxyphenylpyruvate (pHPP) on it. pHPP is an intermediate of the PHE/TYR catabolic pathway, selected as analogue of the ethyl pyruvate (EP), which proved to exhibit antioxidant and anti-inflammatory activities...
2017: PloS One
https://www.readbyqxmd.com/read/29169909/ethyl-pyruvate-attenuates-myocardial-ischemia-reperfusion-injury-exacerbated-by-hyperglycemia-via-retained-inhibitory-effect-on-hmgb1
#20
Sarah Soh, Ji Hae Jun, Jong Wook Song, Eun-Jung Shin, Young-Lan Kwak, Jae-Kwang Shim
BACKGROUND: Hyperglycemia (HG) exacerbates myocardial ischemia/reperfusion (I/R) injury and renders protective strategies ineffective by amplified inflammatory response via enhanced high-mobility group box-1 (HMGB1) release. This study investigated the role of ethyl pyruvate (EP) against myocardial I/R injury under a clinically relevant HG condition. METHODS: Sprague-Dawley rats (n=76) were randomly assigned to 6 groups: normoglycemia (NG)-Sham, NG-I/R-control (C, saline), NG-I/R-EP treatment (50mg/kg) upon reperfusion, HG-Sham, HG-I/R-C, and HG-I/R-EP treatment upon reperfusion...
February 1, 2018: International Journal of Cardiology
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