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B7-H3

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https://www.readbyqxmd.com/read/27874953/the-expression-of-b7-h3-and-b7-h4-in-human-gallbladder-carcinoma-and-their-clinical-implications
#1
C-L Liu, X-X Zang, H Huang, H Zhang, C Wang, Y-L Kong, H-Y Zhang
OBJECTIVE: To investigate the expression of B7-H3 and B7-H4 and their clinical implications in human gallbladder carcinoma. PATIENTS AND METHODS: The expression of B7-H3 and B7-H4 in the 252 samples (126 cases of chronic cholecystitis and 126 cases of gallbladder cancer) was detected by the streptavidin-peroxidase immunohistochemical method, and their associations with tumor classification, clinical grade, and recurrence were assessed. RESULTS: In chronic cholecystitis tissue, B7-H3 and B7-H4 were not detected...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27835582/overexpression-of-b7-h3-correlates-with-aggressive-clinicopathological-characteristics-in-non-small-cell-lung-cancer
#2
Shanshan Wu, Xiangfei Zhao, Sudong Wu, Rui Du, Qi Zhu, Henghu Fang, Xinhong Zhang, Chunyang Zhang, Wei Zheng, Jihua Yang, Huasong Feng
Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis. We searched the electronic databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the impact of B7-H3 on overall survival (OS)...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27801901/correlation-of-b7-h3-with-androgen-receptor-immune-pathways-and-poor-outcome-in-prostate-cancer-an-expression-based-analysis
#3
B Benzon, S G Zhao, M C Haffner, M Takhar, N Erho, K Yousefi, P Hurley, J L Bishop, J Tosoian, K Ghabili, M Alshalalfa, S Glavaris, B W Simons, P Tran, E Davicioni, R J Karnes, K Boudadi, E S Antonarakis, E M Schaeffer, C G Drake, F Feng, A E Ross
BACKGROUND: B7-H3 (CD276), part of the B7 superfamily of immune checkpoint molecules, has been shown to have an immunomodulatory role. Its regulation, receptor and mechanism of action remain unclear. B7-H3 protein expression correlates with prostate cancer outcomes, and humanized monoclonal antibodies (that is, enoblituzumab) are currently being investigated for therapeutic use. Here we used genomic expression data to examine the relationship between B7-H3 mRNA expression and prostate cancer...
November 1, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27785073/epidermal-growth-factor-receptor-and-b7-h3-expression-in-esophageal-squamous-tissues-correlate-to-patient-prognosis
#4
Jianxiang Song, Woda Shi, Yajun Zhang, Mingzhong Sun, Xiaodong Liang, Shiying Zheng
Biomarkers that can serve as diagnostic and prognostic indicators of esophageal squamous cell carcinoma (ESCC) are urgently needed to help improve patient outcomes. Here, the expression of epidermal growth factor receptor (EGFR) and costimulatory molecule B7-H3, both of which have been implicated in tumor onset and progression in certain tumors, was investigated in relation to the clinical characteristics and survival outcomes of patients with ESCC. ESCC tissue samples were analyzed for 100 patients. Tumor and patient characteristics were recorded...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27784389/-expression-and-subcellular-distribution-of-costimulatory-molecules-b7-h1-b7-h3-and-b7-h4-in-human-hematologic-malignancy-cell-lines
#5
Wei Zhang, Jing Wang, Yan-Fang Wang, Ming-Xia Zhu, Wen-Li Wan, Hai-Shen Li, Fei-Fei Wu, Xin-Xing Yan, Xiao-Yan Ke
OBJECTIVE: To investigate the expression and subcellular distribution of costimulatory molecules B7-H1, B7-H3 and B7-H4 in human hematologic malignancy cell lines. METHODS: The expression and subcellular distribution of B7-H1, B7-H3 and B7-H4 in 13 human hematologic malignancy cell lines were determined by RT-PCR, qPCR, Western blot and flow cytometry, the peripheral blood mononuclear cells (PB MNC) of 12 volunteers were used as control. RESULTS: The mRNA of B7-H1, B7-H3 and B7-H4 was widely expressed in PB MNC and hematologic malignancy cell lines, with a lower level of B7-H4...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27764786/assessment-of-combined-expression-of-b7-h3-and-b7-h4-as-prognostic-marker-in-esophageal-cancer-patients
#6
Lujun Chen, Quanqin Xie, Zhigang Wang, Liangrong Shi, Changping Wu, Jingting Jiang
The co-stimulatory ligands of B7-family have been confirmed to play an important role in negatively regulating the T-cell mediated anti-tumor immunity. In addition, these inhibitory molecules are also aberrantly expressed on various human cancers tissues, and significantly associated with cancer progression and patients' poor prognoses. We have previously reported that B7-H3 and B7-H4 ligands are highly expressed in human esophageal cancer tissues. Herein, we tried to further analyze the value of their combined expression on prognostic prediction for esophageal cancer patients...
October 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27721121/withdrawn-tumor-b7-h3-cd276-expression-and-smoking-history-in-relation-to-lung-adenocarcinoma-prognosis
#7
Kentaro Inamura, Yusuke Yokouchi, Maki Kobayashi, Rie Sakakibara, Hironori Ninomiya, Sophia Subat, Hiroko Nagano, Kimie Nomura, Sakae Okumura, Tomoko Shibutani, Yuichi Ishikawa
The Publisher regrets that this article is an accidental duplication of an article that has already been published in The Journal of Lung Cancer - http://dx.doi.org/10.1016/j.lungcan.2016.11.013. Please see online announcement for additional details. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
October 1, 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27667469/-identification-and-characterization-of-monoclonal-antibody-y4f11-against-human-b7-h3
#8
Zhengpeng Shi, Yumin Hu, Hanqing Chen, Fengqing Fu, Xueguang Zhang
Objective To generate mouse anti-human monoclonal antibodies against the molecules expressed on immune cells from malignant pleural effusions, and identify the antigen recognized by the monoclonal antibody named Y4F11. Methods The cells separated from pleural effusions of lung cancer patients were used to immunize BALB/c mice. Hybridoma technology was used for cell fusion and screening; the monoclonal antibody named Y4F11 was chosen as the object for the following experiment. Flow cytometry was performed to analyze the molecules expressed on naive and activated T, B, NK cells and monocytes; Co-immunoprecipitation was conducted to get the antigen pulled down by Y4F11...
October 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27644254/the-tumor-suppressor-mir-124-inhibits-cell-proliferation-and-invasion-by-targeting-b7-h3-in-osteosarcoma
#9
Ling Wang, Fu-Biao Kang, Nan Sun, Juan Wang, Wei Chen, Dong Li, Bao-En Shan
Our previous studies have shown that the expression level of B7 homolog 3 (B7-H3) was correlated with clinical staging and prognosis of osteosarcoma (OS) patients, and its silencing inhibited the proliferation and invasion of OS cells in vitro. However, its overexpression mechanism behind was far from elucidated. On the basis of bioinformatics and the preliminary screening data, we hypothesized that miR-124 might play an important role in OS development and as a lead candidate for modulating B7-H3 expression...
September 20, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27626927/b7-h3-overexpression-predicts-poor-survival-of-cancer-patients-a-meta-analysis
#10
Zhimeng Ye, Zhuojun Zheng, Xiaodong Li, Yuandong Zhu, Zhaoping Zhong, Linrui Peng, Yanyan Wu
BACKGROUND: B7-H3 exhibits altered expression in various cancers. However, the correlation between B7-H3 expression and prognosis of cancer patients remains controversial. Therefore, we elicit a meta-analysis to investigate the potential value of B7-H3 in the prognostic prediction in human cancers. MATERIALS AND METHODS: We searched PubMed (last update by June 15th, 2016) to identify studies assessing the effect of B7-H3 on survival of cancer patients. Hazard ratios (HRs) for overall survival (OS), recurrence free survival (RFS) and progression-free survival (PFS) from individual studies were calculated and pooled by using a random-effect or fix-effect model, and heterogeneity and publication bias analyses were also performed...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27626488/tgf-%C3%AE-1-promotes-colorectal-cancer-immune-escape-by-elevating-b7-h3-and-b7-h4-via-the-mir-155-mir-143-axis
#11
Xinru Zhou, Yong Mao, Jianjie Zhu, Fanyi Meng, Qi Chen, Lihua Tao, Rui Li, Fengqing Fu, Cuiping Liu, Yuanjia Hu, Weipeng Wang, Hongjian Zhang, Dong Hua, Weichang Chen, Xueguang Zhang
Transforming growth factor-beta 1 (TGF-β1) suppresses T cell function, promoting tumor immune escape. Yet, whether the depression of TGF-β1 on T cell function is mediated by co-inhibitory molecules B7-H3 and B7-H4 remains largely unclear. Here, we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4. The upregulated miR-155 attenuated miR-143 by inhibiting its direct target, the transcription factor CEBPB. Consequently, the direct target genes of miR-143, B7-H3 and B7-H4, were augmented in the cytoplasm and membrane of tumor cells...
September 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27609569/-elevated-expression-of-b7-h6-in-u87-cells-derived-glioma-stem-like-cells-is-associated-with-biological-characteristics
#12
Hanqing Chen, Zhengpeng Shi, Bing Gao, Fengqing Fu, Xueguang Zhang
Objective To investigate the expression and biological significance of costimulatory molecule B7-H6, a member of B7 family, in glioma stem like cells (GSLCs). Methods In virtue of the ability of forming neurospheres in vitro , GSLCs were isolated from U87 cells by cell sub-cloning. Real-time quantitative PCR and flow cytometry were performed to detect the expressions of stem cell related markers (c-myc, Sox2, CD133, nestin, and CXCR4), as well as the expressions of B7 family molecules. The different doses of adriamycin, carboplatin, cisplatin, were used to treat GSLCs for testing their chemotherapy-resistance...
September 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27599744/wide-application-of-a-novel-topoisomerase-i-inhibitor-based-drug-conjugation-technology
#13
Yusuke Ogitani, Yuki Abe, Takuma Iguchi, Junko Yamaguchi, Tomoko Terauchi, Michiko Kitamura, Koichi Goto, Mayumi Goto, Masataka Oitate, Hideo Yukinaga, Yoshiyuki Yabe, Takashi Nakada, Takeshi Masuda, Koji Morita, Toshinori Agatsuma
To establish a novel and widely applicable payload-linker technology for antibody-drug conjugates (ADCs), we have focused our research on applying exatecan mesylate (DX-8951f), a potent topoisomerase I inhibitor, which exhibits extensive antitumor activity as well as significant myelotoxicity, as the payload part. Through this study, we discovered a promising exatecan derivative (DX-8951 derivative, DXd), that has the characteristics of low membrane permeability and shows considerably less myelotoxicity than that shown by exatecan mesylate in an in vitro human colony forming unit-granulocyte macrophage assay...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27593566/tumor-derived-immuno-modulators-induce-overlapping-pro-tolerogenic-gene-expression-signatures-in-human-dendritic-cells
#14
Stefanie Trojandt, Iris Bellinghausen, Angelika B Reske-Kunz, Matthias Bros
Immature dendritic cells (iDCs) and tolerogenic DCs are essential for the induction and maintenance of peripheral tolerance. Tumors produce immuno-modulatory factors which imprint a pro-tolerogenic, maturation-resistant state in DCs. Here we asked for common markers of differentially tolerized human monocyte-derived DC populations. For this, PBMC-derived monocytes were differentiated to DCs in the presence of established immuno-modulators as released by tumors (IL-6, IL-10, TGF-ß, glucocorticoid [GC], prostaglandin E2 [PGE2])...
September 1, 2016: Human Immunology
https://www.readbyqxmd.com/read/27459969/assessment-of-plasma-b7-h3-levels-in-pediatric-patients-with-different-degrees-of-surgical-stress
#15
Yan Li, Qing Yuan, Jie Huang, Yi Ping Li, Jian Pan, Xing Feng, Xue Guang Zhang, Jiang Huai Wang, Jian Wang
BACKGROUND: Surgical stress initiates a series of host hormone, metabolism and immune responses, which predominantly affect the homeostatic mechanism of patients with major surgery. B7-H3 is a co-stimulatory molecule and has been shown to participate in both adaptive and innate immune responses. In this study we evaluated the clinical significance of plasma B7-H3 levels in pediatric patients with different types of operation and degrees of surgical stress. METHODS: A total of 48 children received pediatric general and cardiac surgery were recruited into this study...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27349980/immune-checkpoint-blockade-in-human-cancer-therapy-lung-cancer-and-hematologic-malignancies
#16
Murali Janakiram, Vipul Pareek, Haiying Cheng, Deepa M Narasimhulu, Xingxing Zang
Tumor immune evasion is one of the hallmarks of cancer, and expression of the B7 family of immune checkpoints (PD-L1, PD-L2, B7-H3, B7x and HHLA2) is one mechanism of immune evasion by tumors to suppress T-cell function. Antibodies blocking these interactions of B7-1/B7-2/CTLA-4 and PD-L1/PD-L2/PD-1 have had remarkable clinical success in several cancers and are less toxic than traditional chemotherapy. Even though only a small proportion of patients respond to checkpoint blockade, the duration of such responders due to immunological memory is remarkable and is longer than would be expected with any other agent in refractory disease...
June 2016: Immunotherapy
https://www.readbyqxmd.com/read/27347155/b7-h3-protein-expression-in-a-murine-model-of-osteosarcoma
#17
Jia-Li Zhao, Feng-Li Chen, Quan Zhou, Wei Pan, Xin-Hong Wang, Jin Xu, Shao-Xian Zhang, L I Ni, Hui-Lin Yang
Osteosarcoma is an aggressive type of bone tumor that commonly occurs in pediatric age groups. The complete molecular mechanisms behind osteosarcoma formation and progression require elucidation. B7-H3 is a protein of the B7 family that acts as a co-stimulatory molecule with a significant role in adaptive immune responses. The link between B7-H3 expression and its role in different types of cancer remains unclear. B7-H3 protein exhibits different functional roles in in vivo and in vitro conditions that remain controversial...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27292320/higher-preoperative-serum-levels-of-pd-l1-and-b7-h4-are-associated-with-invasive-and-metastatic-potential-and-predictable-for-poor-response-to-vegf-targeted-therapy-and%C3%A2-unfavorable-prognosis-of-renal-cell-carcinoma
#18
Takehiko Fukuda, Takao Kamai, Akinori Masuda, Akinori Nukui, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida
Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer. Although antivascular endothelial growth factor (VEGF) therapies achieve impressive responses in some patients, many tumors eventually develop resistance to such therapy. The B7 family molecules such as CTLA-4, PD-1, and PD-L1 are pivotal players in immune checkpoints that positively or negatively regulate various immune responses. Recently, immunotherapy based on blocking immune checkpoints with anti-CTLA4, anti-PD-1, or anti-PD-L1 antibodies has been proposed as a potential new approach to the treatment of metastatic RCC...
August 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27273624/soluble-b7-h3-promotes-the-invasion-and-metastasis-of-pancreatic-carcinoma-cells-through-the-tlr4-nf-%C3%AE%C2%BAb-pathway
#19
Chao Xie, Danqing Liu, Qijun Chen, Chong Yang, Bo Wang, Heshui Wu
Many studies have demonstrated a relationship between soluble B7-H3 (sB7-H3) and the poor prognosis of patients with malignant tumors, and increasing evidence has shown a connection between sB7-H3 and NF-κB in tumor progression. In the present study, we demonstrate for the first time that sB7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-κB pathway. In this study, we observed that sB7-H3 was highly expressed in mB7-H3-positive pancreatic carcinoma (PCa) cells. Exogenous sB7-H3 significantly increased NF-κB activity and promoted the migration and invasion of PCa cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27222007/preparation-and-application-of-a-novel-monoclonal-antibody-specific-for-human-b7-h3
#20
Jian Shi, Dong-Lei Zhang, Zhi-Chu Cui, Hui-Min Wang
Human B7-H3 (CD276), as a new member of the B7 family has been demonstrated to mediate T cell proliferation and the production of interferon‑γ. Two isoforms of B7-H3 have been identified in humans, 2IgB7‑H3 and 4IgB7‑H3. Since the costimulatory functions of the two isoforms remains to be fully elucidated, there are disagreements regarding their expression patterns as well as the T cell responses. In the present study, a single mouse anti‑human monoclonal antibody (mAb), specific for 2IgB7‑H3 and 4IgB7‑H3 was established, termed 11F4...
July 2016: Molecular Medicine Reports
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