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sarcoidosis and radionuclide imaging

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This joint position paper illustrates the role and the correct use of echocardiography, radionuclide imaging with 18F-fluorodeoxyglucose positron emission tomography, radionuclide myocardial perfusion imaging and cardiovascular magnetic resonance imaging for the evaluation and management of patients with known or suspected cardiac sarcoidosis. This position paper will aid in standardizing imaging for cardiac sarcoidosis and may facilitate clinical trials and pooling of multi-centre data on cardiac sarcoidosis...
October 1, 2017: European Heart Journal Cardiovascular Imaging
Andreas Buck, Clemens Decristoforo
The EANM 2015 Annual Congress, held from October 10th to 14th in Hamburg, Germany, was outstanding in many respects. With 5550 participants, this was by far the largest European congress concerning nuclear medicine. More than 1750 scientific presentations were submitted, with more than 250 abstracts from young scientists, indicating that the future success of our discipline is fuelled by a high number of young individuals becoming involved in a multitude of scientific activities. Significant improvements have been made in molecular imaging of cancer, particularly in prostate cancer...
September 2016: European Journal of Nuclear Medicine and Molecular Imaging
Syahminan Suut, Zeid Al-Ani, Carolyn Allen, Prabhakar Rajiah, Durr-E-Sabih, Abdullah Al-Harbi, Hamdan Al-Jahdali, Ali Nawaz Khan
With increased exposure of patients to routine imaging, incidental benign intrathoracic masses are frequently recognized. Most have classical imaging features, which are pathognomonic for their benignity. The aim of this pictorial review is to educate the reader of radiological features of several types of intrathoracic masses. The masses are categorized based on their location/origin and are grouped into parenchymal, pleural, mediastinal, or bronchial. Thoracic wall masses that invade the thorax such as neurofibromas and lipomas are included as they may mimic intrathoracic masses...
October 2015: Annals of Thoracic Medicine
John P Bois, Panithaya Chareonthaitawee
Radionuclide imaging provides both established and emerging diagnostic and prognostic tools to assist clinicians in the management of patients with ischemic cardiomyopathy, cardiac sarcoidosis, and cardiac amyloidosis. This review highlights the underlying pathophysiology of each entity and associated diagnostic and clinical challenges, and describes the available radionuclide imaging techniques. Specific protocols, advantages and disadvantages, comparison with other noninvasive imaging modalities, and discussion of the evolving role of hybrid imaging are also included...
February 2016: Cardiology Clinics
Lieke S Kamphuis, Dik J Kwekkeboom, Tom O Missotten, G Seerp Baarsma, Virgil A Dalm, Willem A Dik, W Marieke Timmermans, Paul L van Daele, P Martin van Hagen, Jan A van Laar
PURPOSE: Sarcoidosis is a multisystem granulomatous disorder, most frequently involving the lungs, skin, or eyes. Somatostatin receptor scintigraphy (SRS) can visualize sarcoid granulomas through binding of a radionuclide-coupled somatostatin analog to somatostatin receptors that are expressed in sarcoidosis. Uptake and patterns on SRS were studied and correlated to clinical and conventional findings. PATIENTS AND METHODS: Data of 218 SRSs undertaken for the analysis of potential sarcoidosis were studied...
December 2015: Clinical Nuclear Medicine
V Kouranos, A U Wells, R Sharma, S R Underwood, K Wechalekar
INTRODUCTION: Radionuclide imaging for the diagnosis and monitoring of cardiac involvement in sarcoidosis has advanced significantly in recent years. SOURCES OF DATA: This article is based on published clinical guidelines, literature review and our collective clinical experience. AREAS OF AGREEMENT: Gallium-67 scintigraphy is among the diagnostic criteria for cardiac involvement in systemic sarcoidosis, and it is strongly associated with response to treatment...
September 2015: British Medical Bulletin
John P Bois, Panithaya Chareonthaitawee
No abstract text is available yet for this article.
April 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
S Vaidyanathan, C N Patel, A F Scarsbrook, F U Chowdhury
Integrated positron emission tomography/computed tomography (PET/CT) with the glucose analogue, 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG), is an evolving hybrid imaging technique in the evaluation of an important and diverse group of pathological conditions, which are characterised by infection and aseptic inflammation. With a rapidly expanding body of evidence, it is being increasingly recognised that, in addition to its established role in oncological imaging, FDG PET/CT also has clinical utility in suspected infection and inflammation...
July 2015: Clinical Radiology
Mario Silva, Hilario Nunes, Dominique Valeyre, Nicola Sverzellati
The diagnostic imaging contributes significantly to the diagnosis and management of sarcoidosis. Imaging techniques are widely employed in the assessment of thoracic and extra-thoracic involvement from sarcoidosis. For the diagnosis of sarcoidosis, chest radiograph has been the cornerstone of sarcoidosis since 1961, when Scadding proposed a standardized staging system. Currently, computed tomography (CT) represents the reference standard for the assessment of both mediastinal lymph nodes and pulmonary findings...
August 2015: Clinical Reviews in Allergy & Immunology
Randeep Guleria, Amudhan Jyothidasan, Karan Madan, Anant Mohan, Rakesh Kumar, Ashu Seith Bhalla, Arun Malhotra
BACKGROUND: Radionuclide imaging modalities have increasingly been evaluated in the assessment of organ involvement in sarcoidosis. Fluoro-deoxyglucose positron emission tomography-computed tomography (FDG-PET-CT) scanning has received increasing attention in the recent years. The aim of our study was to evaluate the utility of FDG-PET-CT in determining the extent of organ involvement and disease activity in patients of sarcoidosis and to assess its utility in the evaluation of response to therapy...
October 2014: Lung India: Official Organ of Indian Chest Society
Ioannis Angomachalelis, Hercules Titopoulos, Nestor Angomachalelis
SESSION TITLE: Interstitial Lung Disease Posters ISESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: : The study aims to evaluate serum angiotensin converting enzyme levels (SACE) and coincident correlation with Technetium radionuclide myocardial imaging(Tc-99m-Pyp) in patients(pts) presented with pulmonary and/or systemic sarcoidosis. METHODS: Serum SACE levels were measured by Hurst's and Lorel-Smith's method in 52 biopsy-proven,Sarcoidosis Pts,15 males and 37 females(mean age 48±12years),without clinical evidence of any other cardiovascular pathology as well as 15 normal individuals (mean age 47±23 years)...
October 1, 2014: Chest
Anna Plitt, Sharmila Dorbala, Michelle A Albert, Robert P Giugliano
INTRODUCTION: Cardiovascular disease is the leading cause of death worldwide, with coronary heart disease being the most common manifestation disease. While deaths attributed to coronary heart disease are falling in the developed world, the number of patients with cardiomyopathy continues to increase. In this paper, the current literature on imaging modalities for infiltrative and inflammatory cardiomyopathies is reviewed, focusing on the three most common diagnoses, namely sarcoidosis, amyloidosis, and myocarditis...
December 2013: Cardiology and Therapy
Joseph P Lynch, Jennifer Hwang, Jason Bradfield, Michael Fishbein, Kalyanam Shivkumar, Roderick Tung
Clinically evident sarcoidosis involving the heart has been noted in at least 2 to 7% of patients with sarcoidosis, but occult involvement is much higher (> 20%). Cardiac sarcoidosis is often not recognized antemortem, as sudden death may be the presenting feature. Cardiac involvement may occur at any point during the course of sarcoidosis and may occur in the absence of pulmonary or systemic involvement. Sarcoidosis can involve any part of the heart, with protean manifestations. Prognosis of cardiac sarcoidosis is related to extent and site(s) of involvement...
June 2014: Seminars in Respiratory and Critical Care Medicine
Brian McArdle, Taylor F Dowsley, Myra S Cocker, Hiroshi Ohira, Robert A deKemp, Jean DaSilva, Terrance D Ruddy, Benjamin J Chow, Rob S Beanlands
Cardiac PET has evolved over the past 30 years to gain wider acceptance as a valuable modality for a variety of cardiac conditions. Wider availability of scanners as well as changes in reimbursement policies in more recent years has further increased its use. Moreover, with the emergence of novel radionuclides as well as further advances in scanner technology, the use of cardiac PET can be expected to increase further in both clinical practice and the research arena. PET has demonstrated superior diagnostic accuracy for the diagnosis of coronary artery disease in comparison with single-photon emission tomography while it provides robust prognostic value...
November 2013: Seminars in Nuclear Medicine
Ioannis Angomachalelis, George Kyriazis, Nestor Angomachalelis
SESSION TYPE: ILD PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: :Nearly 21% of pulmonary and/or systemic Sarcoidosis (S) patients (pts) appeared developing pericardial involvement in their initial Hospital admission.This study investigates evaluation of the total ,multi stage,pericardial effusion frequency (P.Ef),not well established and reported in the literature.METHODS: 178/278 biopsy-proven ,pulmonary and/or systemic Sarcoidosis Pts,56 males and 122 females,mean age 47,8 yrs,were free of other clinical cardiovascular pathology and investigated for the possible development of the multi-stage,symptomatic or latent,pericardial granulomatosis...
October 1, 2012: Chest
Q H Li, H P Li, Y P Shen, L Zhao, L Shen, Y Zhang, D H Jiang, R P Baughman
BACKGROUND: Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs. Tuberculosis is the world's second most common cause of death from infectious diseases. Due to the similar clinical, radiological and histopathological pictures in sarcoidosis and tuberculosis, Mycobacterium tuberculosis has been considered as potential infectious factor. However, it remains difficult to distinguish sarcoidosis from tuberculosis, especially when sputum examinations for mycobacterium are negative...
March 2012: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
K U Bauner, B Wintersperger
CLINICAL/METHODICAL ISSUE: Sarcoidosis and amyloidosis are both multisystem disorders, which may involve the heart; however, isolated cardiac disease is rare. Diagnosis of cardiac sarcoidosis and amyloidosis is crucial because the patient prognosis is dependent on cardiac involvement and early treatment. STANDARD RADIOLOGICAL METHODS: Echocardiography is the first line imaging modality in the diagnostic work-up of both diseases, possibly giving hints towards the correct diagnosis...
January 2013: Der Radiologe
Ruth G M Keijsers, Daniel A F van den Heuvel, Jan C Grutters
Accurate assessment of pulmonary and extrapulmonary organ involvement in sarcoidosis is one of the great challenges for clinicians. This assessment includes the evaluation of symptoms and of sarcoidosis activity in a specific organ and its functional consequences. In this review, radiological and nuclear techniques to image the inflammatory activity of sarcoidosis are described, in particular (18)F-FDG positron emission tomography/computed tomography. The current use of this technique in clinical practice is explained, particularly in patients with persistent symptoms, stage IV disease and cardiac sarcoidosis...
March 2013: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Grigorios T Sakellariou, Athanasios D Anastasilakis, Dimitrios Karanikolas, Periklis Vounotrypidis, Charalampos Berberidis
We report a case of multifocal involvement of the central skeleton in a patient with long-term stage I pulmonary sarcoidosis who experienced sustained clinical remission of musculoskeletal symptoms while on methotrexate (MTX) alone. Concomitant normalization of laboratory tests [inflammatory markers and angiotensin-converting enzyme (ACE) levels] was observed, and improvements were seen in follow-up magnetic resonance imaging (MRI) of the lumbar spine and bone scintigraphy. To date, there are no specific tools for the assessment of skeletal disease activity in sarcoidosis...
January 2013: Modern Rheumatology
Rajesh Janardhanan, George A Beller
This article discusses currently available radionuclide techniques in the diagnostic and prognostic evaluation of patients with chronic heart failure, with a focus on stage B/asymptomatic left ventricular dysfunction. Radionuclide imaging is promising for such patients because it can simultaneously determine left ventricular function, evaluate for the presence of obstructive coronary disease, determine the extent of viable myocardium, and evaluate dyssynchronous left ventricular contraction. Radionuclide imaging can thus provide important noninvasive insights into the pathophysiology, prognosis, and management of patients with asymptomatic left ventricular dysfunction as well as more advanced heat failure...
April 2012: Heart Failure Clinics
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