Stefan Kurtenbach, Margaret I Sanchez, Jeffim Kuznetsoff, Daniel A Rodriguez, Natalia Weich, James J Dollar, Anthony Cruz, Sarah Kurtenbach, Matthew G Field, Michael A Durante, Christina Decatur, Mahsa Sorouri, Fan Lai, Gulum Yenisehirli, Bin Fang, Ramin Shiekhattar, Daniel Pelaez, Zelia M Correa, Ramiro E Verdun, J William Harbour
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in spermatogonia around the time of meiotic crossing-over in coordination with genes mediating DNA double strand break repair. Expression of PRAME in somatic cells upregulates pathways involved in meiosis, chromosome segregation and DNA repair, and it leads to increased DNA double strand breaks, telomere dysfunction and aneuploidy in neoplastic and non-neoplastic cells...
November 29, 2023: Oncogene