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PRAME

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https://www.readbyqxmd.com/read/27875783/prame-overexpression-predicted-good-outcome-in-pediatric-b-cell-acute-lymphoblastic-leukemia-patients-receiving-chemotherapy
#1
Yan-Huan Zhang, Ai-Dong Lu, Lu Yang, Ling-Di Li, Wen-Min Chen, Ling-Yu Long, Le-Ping Zhang, Ya-Zhen Qin
To investigate the prognostic value of PRAME expression in pediatric acute lymphoblastic leukemia(ALL), we measured PRAME transcript levels at diagnosis in 191 patients(146 B-ALL; 45T-ALL)receiving chemotherapy only. PRAME overexpression was defined as transcript levels higher than 0.30%, which is the upper limit of normal bone marrow and the optimal cutoff value derived from ROC curve analysis. PRAME overexpression was identified in 45.5% of patients. In B-ALL, PRAME overexpression was significantly associated with lower CIR(cumulative incidence of relapse), higher DFS (disease-freesurvival), and OS(overall survival) rates at 3 years, respectively (5...
November 11, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27843625/safety-and-immunogenicity-of-the-prame-cancer-immunotherapeutic-in-metastatic-melanoma-results-of-a-phase-i-dose-escalation-study
#2
R Gutzmer, L Rivoltini, E Levchenko, A Testori, J Utikal, P A Ascierto, L Demidov, J J Grob, R Ridolfi, D Schadendorf, P Queirolo, A Santoro, C Loquai, B Dreno, A Hauschild, E Schultz, T P Lesimple, N Vanhoutte, B Salaun, M Gillet, S Jarnjak, P M De Sousa Alves, J Louahed, V G Brichard, F F Lehmann
PURPOSE: The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. PATIENTS AND METHODS: Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic...
2016: ESMO Open
https://www.readbyqxmd.com/read/27794402/the-prevalence-of-expression-of-mage-a3-and-prame-tumor-antigens-in-east-and-south-east-asian-non-small-cell-lung-cancer-patients
#3
Sumitra Thongprasert, Pan-Chyr Yang, Jung Shin Lee, Ross Soo, Olivier Gruselle, Aung Myo, Jamila Louahed, Frédéric F Lehmann, Vincent G Brichard, Thierry Coche
INTRODUCTION: Treatment of non-small cell lung cancer (NSCLC) is an important and often unmet medical need regardless of the disease stage at the time of first diagnosis. Antigen-specific immunotherapy may be a feasible therapeutic option if tumor associated antigens (TAAs) that can be targeted by the patient's immune system are identified. The study objective (NCT01837511) was to investigate the expression rates of MAGE-A3 and PRAME in tumors from East Asian NSCLC patients, and the associations between TAA expression and clinico-pathologic patient characteristics...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27776018/inhibitor-of-vasculogenic-mimicry-restores-sensitivity-of-resistant-melanoma-cells-to-dna-damaging-agents
#4
Amalia Vartanian, Maria Baryshnikova, Olga Burova, Dariya Afanasyeva, Vsevolod Misyurin, Alexander Belyаvsky, Zoya Shprakh
The increasing incidence of melanoma makes this cancer an important public health problem. Therapeutic resistance is still a major obstacle to the therapy of patients with metastatic melanomas. The aim of this study was to develop the melanoma cell line resistant to DNA-alkylating agents and to elucidate the mechanisms involved in acquired drug resistance. We established a unique melanoma subline Mel MeR resistant to DNA-alkylating drug aranoza by continuous stepwise selection of the Mel Me/WT cell line with increasing concentrations of this drug...
October 21, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27707590/development-and-validation-of-a-noninvasive-2-gene-molecular-assay-for-cutaneous-melanoma
#5
Pedram Gerami, Zuxu Yao, David Polsky, Burkhard Jansen, Klaus Busam, Jonhan Ho, Mary Martini, Laura K Ferris
BACKGROUND: Clinical and histopathologic assessment of pigmented skin lesions remains challenging even for experts. Differentiated and accurate noninvasive diagnostic modalities are highly desirable. OBJECTIVE: We sought to provide clinicians with such a tool. METHODS: A 2-gene classification method based on LINC00518 and preferentially expressed antigen in melanoma (PRAME) gene expression was evaluated and validated in 555 pigmented lesions (157 training and 398 validation samples) obtained noninvasively via adhesive patch biopsy...
October 1, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27632898/prame-is-critical-for-breast-cancer-growth-and-metastasis
#6
Zhengwang Sun, Zhipeng Wu, Fenglin Zhang, Qunfeng Guo, Lin Li, Kun Li, Hui Chen, Juan Zhao, Dianwen Song, Quan Huang, Lei Li, Jianru Xiao
Breast cancer is the most common cause of cancer death in women and ranks second among cancer deaths. Metastasis is the main cause of death in breast cancer patients. However, the mechanisms underlying the invasion and metastasis of breast cancer cells remain largely elusive. Here we report that the protein PRAME, a tumor-associated antigen isolated from a melanoma, plays a role in preventing the proliferation and metastasis of breast cancer cells. Knocking down of PRAME promotes breast cancer cell proliferation and inhibits apoptosis...
December 5, 2016: Gene
https://www.readbyqxmd.com/read/27603913/cancer-testis-antigens-expression-regulation-tumor-invasion-and-use-in-immunotherapy-of-cancers
#7
Arash Salmaninejad, Mohammad Reza Zamani, Mehrnaz Pourvahedi, Zahra Golchehre, Ali Hosseini Bereshneh, Nima Rezaei
UNLABELLED: Cancer/testis antigens (CTAs) are named based on their expression pattern that is restricted in a number of normal and abnormal tissues. Tumor cells frequently express antigens whose expression is typically restricted to germ cells. Their unique expression pattern is guaranteed by precise epigenetic regulatory mechanisms. Because of their tumor-limited, high immunogenicity, and biased expression, discovery of these molecules provides unprecedented opportunities for further research and clinical development in the field of cancer diagnosis and immunotherapy...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27544054/safety-and-immunogenicity-of-the-prame-cancer-immunotherapeutic-in-patients-with-resected-non-small-cell-lung-cancer-a-phase-i-dose-escalation%C3%A2-study
#8
Jean-Louis Pujol, Tommaso De Pas, Achim Rittmeyer, Eric Vallières, Bartosz Kubisa, Eugeny Levchenko, Sebastian Wiesemann, Gregory A Masters, Robert Shen, Sergei A Tjulandin, Hans-Stefan Hofmann, Nicolas Vanhoutte, Bruno Salaun, Muriel Debois, Silvija Jarnjak, Pedro Miguel De Sousa Alves, Jamila Louahed, Vincent G Brichard, Frédéric F Lehmann
INTRODUCTION: Adjuvant platinum-based chemotherapy is standard treatment for surgically resected stage II to IIIA NSCLC, but the relapse rate is high. The preferentially expressed antigen of melanoma (PRAME) tumor antigen is expressed in two-thirds of NSCLC and offers an attractive target for antigen-specific immunization. A phase I dose escalation study assessed the safety and immunogenicity of a PRAME immunotherapeutic consisting of recombinant PRAME plus proprietary immunostimulant AS15 in patients with surgically resected NSCLC (NCT01159964)...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27519286/gene-expression-of-mage-a3-and-prame-tumor-antigens-and-egfr-mutational-status-in-taiwanese-non-small-cell-lung-cancer-patients
#9
Szu-Hua Pan, Kang-Yi Su, Bart Spiessens, Nicole Kusuma, Nicolas F Delahaye, Olivier Gruselle, Aung Myo, An de Creus, Jamila Louahed, Gee-Cheng Chang, Sung-Liang Yu, Pan-Chyr Yang
AIM: To determine the frequency of expression of the tumor-associated antigens (TAAs) melanoma-associated antigen A3 (MAGE-A3) and preferentially expressed antigen of melanoma (PRAME) and the rate of EGFR mutations in a Taiwanese non-small cell lung cancer (NSCLC) population including only adenocarcinomas and squamous cell carcinomas. Furthermore, to investigate associations between TAA expression and EGFR mutations and to evaluate these TAAs as prognostic markers for overall survival...
August 12, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27505074/analytical-characteristics-of-a-noninvasive-gene-expression-assay-for-pigmented-skin-lesions
#10
Zuxu Yao, Talisha Allen, Margaret Oakley, Carol Samons, Darryl Garrison, Burkhard Jansen
We previously reported clinical performance of a novel noninvasive and quantitative PCR (qPCR)-based molecular diagnostic assay (the pigmented lesion assay; PLA) that differentiates primary cutaneous melanoma from benign pigmented skin lesions through two target gene signatures, LINC00518 (LINC) and preferentially expressed antigen in melanoma (PRAME). This study focuses on analytical characterization of this PLA, including qPCR specificity and sensitivity, optimization of RNA input in qPCR to achieve a desired diagnostic sensitivity and specificity, and analytical performance (repeatability and reproducibility) of this two-gene PLA...
August 2016: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/27490939/the-in-vitro-generation-of-multi-tumor-antigen-specific-cytotoxic-t-cell-clones-candidates-for-leukemia-adoptive-immunotherapy-following-allogeneic-stem-cell-transplantation
#11
Yehia S Mohamed, Layla A Bashawri, Chittibabu Vatte, Eman Y Abu-Rish, Cyril Cyrus, Wafaa S Khalaf, Michael J Browning
Adoptive T-cell immunotherapy is a promising approach to manage and maintain relapse-free survival of leukemia patients, especially following allogeneic stem cell transplantation. Post-transplant adoptive immunotherapy using cytotoxic T lymphocytes (CTLs) of the donor origin provide graft-versus-tumor effects, with or without graft-versus-host disease. Myeloid leukemias express immunogenic leukemia associated antigens (LAAs); such as WT-1, PRAME, MAGE, h-TERT and others, most of them are able to induce specific T cell responses whenever associated with the proper co-stimulation...
September 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27486988/epigenetic-reprogramming-and-aberrant-expression-of-prame-are-associated-with-increased-metastatic-risk-in-class-1-and-class-2-uveal-melanomas
#12
Matthew G Field, Michael A Durante, Christina L Decatur, Bercin Tarlan, Kristen M Oelschlager, John F Stone, Jeffim Kuznetsov, Anne M Bowcock, Stefan Kurtenbach, J William Harbour
BACKGROUND: We previously identified PRAME as a biomarker for metastatic risk in Class 1 uveal melanomas. In this study, we sought to define a threshold value for positive PRAME expression (PRAME+) in a large dataset, identify factors associated with PRAME expression, evaluate the prognostic value of PRAME in Class 2 uveal melanomas, and determine whether PRAME expression is associated with aberrant hypomethylation of the PRAME promoter. RESULTS: Among 678 samples analyzed by qPCR, 498 (73...
July 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27441500/the-cancer-testis-antigen-prame-supports-the-pluripotency-network-and-represses-somatic-and-germ-cell-differentiation-programs-in-seminomas
#13
Daniel Nettersheim, Isabell Arndt, Rakesh Sharma, Stefanie Riesenberg, Sina Jostes, Simon Schneider, Michael Hölzel, Glen Kristiansen, Hubert Schorle
BACKGROUND: Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME is expressed in various cancers, antagonises retinoic acid signalling and is regulated by DNA methylation and histone acetylation. METHODS: We analysed the molecular function of the CTA PRAME in primordial germ cells (PGC) and testicular germ cell cancers (GCC)...
August 9, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27441497/prame-as-diagnostic-marker-and-as-regulator-for-cell-fate-decisions-in-germ-cell-cancers
#14
EDITORIAL
Nina Neuhaus
No abstract text is available yet for this article.
August 9, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27391090/preferentially-expressed-antigen-of-melanoma-prevents-lung-cancer-metastasis
#15
Quan Huang, Haifeng Wei, Zhipeng Wu, Lin Li, Liangfang Yao, Zhengwang Sun, Lei Li, Zaijun Lin, Wei Xu, Shuai Han, Wenjiao Cao, Yunfei Xu, Dianwen Song, Xinghai Yang, Jianru Xiao
Lung cancer is the most common cause of cancer death worldwide. The poor survival rate is largely due to the extensive local invasion and metastasis. However, the mechanisms underlying the invasion and metastasis of lung cancer cells remain largely elusive. In this study, we examined the role of preferentially expressed antigen of melanoma (PRAME) in lung cancer metastasis. Our results show that PRAME is downregulated in lung adenocarcinoma and lung bone metastasis compared with normal human lung. Knockdown of PRAME decreases the expression of E-Cadherin and promotes the proliferation, invasion, and metastasis of lung cancer cells by regulating multiple critical genes, most of which are related to cell migration, including MMP1, CCL2, CTGF, and PLAU...
2016: PloS One
https://www.readbyqxmd.com/read/27323861/expression-of-tumor-antigens-on-primary-ovarian-cancer-cells-compared-to-established-ovarian-cancer-cell-lines
#16
Kamila Kloudová, Hana Hromádková, Simona Partlová, Tomáš Brtnický, Lukáš Rob, Jiřina Bartůňková, Michal Hensler, Michael J Halaška, Radek Špíšek, Anna Fialová
In order to select a suitable combination of cancer cell lines as an appropriate source of antigens for dendritic cell-based immunotherapy of ovarian cancer, we analyzed the expression level of 21 tumor associated antigens (BIRC5, CA125, CEA, DDX43, EPCAM, FOLR1, Her-2/neu, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A10, MAGE-A12, MUC-1, NY-ESO-1, PRAME, p53, TPBG, TRT, WT1) in 4 established ovarian cancer cell lines and in primary tumor cells isolated from the high-grade serous epithelial ovarian cancer tissue...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27322684/prame-expression-and-promoter-hypomethylation-in-epithelial-ovarian-cancer
#17
Wa Zhang, Carter J Barger, Kevin H Eng, David Klinkebiel, Petra A Link, Angela Omilian, Wiam Bshara, Kunle Odunsi, Adam R Karpf
PRAME is a cancer-testis antigen (CTA) and potential immuno-therapeutic target, but has not been well-studied in epithelial ovarian cancer (EOC) or its high grade serous (HGSC) subtype. Compared to normal ovary, PRAME expression was significantly increased most EOC, regardless of stage and grade. Interestingly, PRAME mRNA expression was associated with improved survival in the HGSC subtype. The PRAME locus was a frequent target for copy number alterations (CNA) in HGSC but most changes were heterozygous losses, indicating that elevated PRAME expression is not typically due to CNA...
June 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27302479/minimal-residual-disease-monitoring-and-preemptive-immunotherapy-in-myelodysplastic-syndrome-after-allogeneic-hematopoietic-stem-cell-transplantation
#18
Xiao-Dong Mo, Ya-Zhen Qin, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang
This study investigated the efficacy of minimal residual disease (MRD) monitoring and MRD-directed preemptive immunotherapy in high-risk myelodysplastic syndrome (MDS) patients who received allogeneic hematopoietic stem cell transplantation (HSCT). MRD assessment consisted of Wilms' tumor gene 1 (WT1) detection with PCR and leukemia-associated immunophenotypic pattern examination with multiparameter flow cytometry (FCM). Post-HSCT, 31 patients were positive for WT1, and 8, for FCM; positivity for WT1 (18.6 vs...
August 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27283990/sox2-is-essential-for-in-vivo-reprogramming-of-seminoma-like-tcam-2-cells-to-an-embryonal-carcinoma-like-fate
#19
Daniel Nettersheim, Alena Heimsoeth, Sina Jostes, Simon Schneider, Martin Fellermeyer, Andrea Hofmann, Hubert Schorle
Type II germ cell cancers (GCC) are divided into seminomas, which are highly similar to primordial germ cells and embryonal carcinomas (EC), often described as malignant counterparts to embryonic stem cells.Previously, we demonstrated that the development of GCCs is a highly plastic process and strongly influenced by the microenvironment. While orthotopic transplantation into the testis promotes seminomatous growth of the seminoma-like cell line TCam-2, ectopic xenotransplantation into the flank initiates reprogramming into an EC-like fate...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27241212/identification-of-preferentially-expressed-antigen-of-melanoma-as-a-potential-tumor-suppressor-in-lung-adenocarcinoma
#20
Quan Huang, Lin Li, Zaijun Lin, Wei Xu, Shuai Han, Chenglong Zhao, Lei Li, Wenjiao Cao, Xinghai Yang, Haifeng Wei, Jianru Xiao
BACKGROUND Preferentially expressed antigen of melanoma (PRAME) is known as a tumor-associated antigen that is altered in a variety of malignancies, including lung cancer. However, the role of PRAME in lung cancer remains unclear. MATERIAL AND METHODS We analyzed the expression of PRAME in human lung adenocarcinomas and studied the function of PRAME using small interfering RNA (siRNA)-induced gene knockdown in lung cancer cell lines PC9 and A549. RESULTS We found that PRAME expression is down-regulated in lung adenocarcinomas...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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