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https://www.readbyqxmd.com/read/29791215/non-pharmacological-approaches-to-non-cognitive-symptoms-in-dementia
#1
Aysha Mendes
No abstract text is available yet for this article.
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29786916/herbal-medicine-as-a-promising-therapeutic-approach-for-the-management-of-vascular-dementia-a-systematic-literature-review
#2
REVIEW
Adel Ghorani-Azam, Samaneh Sepahi, Elham Khodaverdi, Seyed Ahmad Mohajeri
Vascular dementia (VaD) generally refers to memory deficits and cognitive abnormalities that are resulted from vascular disease. In this study, we aimed to systematically review the literature wherein therapeutic effects of medicinal plants have been studied on VaD. A systematic literature search was performed in the PubMed, Scopus, Web of Science, Google Scholar, and other databases using VaD, and medicinal plants as key terms. No strict inclusion criteria were defined, and almost all clinical studies were included...
May 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29785112/treatment-of-behavioral-and-psychological-symptoms-of-dementias-with-psychopharmaceuticals-a-review
#3
REVIEW
Jiří Masopust, Dita Protopopová, Martin Vališ, Zbyšek Pavelek, Blanka Klímová
Behavioral and psychological symptoms represent common complications in patients with different types of dementia. Predominantly, they comprise psychosis, agitation and mood disorders, disinhibited behavior, impairment of the sleep and wakefulness rhythm, wandering, perseveration, pathological collecting, or shouting. Their appearance is related to more rapid progression of the disease, earlier institutionalization, use of physical restraints, and higher risk of mortality. Consequently, appearance of behavioral and psychological symptoms of dementia leads to higher costs of care provided and greater distress for caregivers...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29783091/mind-at-home-streamlined-study-protocol-for-a-randomized-trial-of-home-based-care-coordination-for-persons-with-dementia-and-their-caregivers
#4
Quincy M Samus, Betty Smith Black, Melissa Reuland, Jeannie-Marie S Leoutsakos, Laura Pizzi, Kevin D Frick, David L Roth, Laura N Gitlin, Constantine G Lyketsos, Deirdre Johnston
BACKGROUND: Dementia is associated with high health care costs, premature long-term care (LTC) placement, medical complications, reduced quality of life, and caregiver burden. Most health care providers and systems are not yet organized or equipped to provide comprehensive long-term care management for dementia, although a range of effective symptoms and supportive care approaches exist. The Maximizing Independence at Home-Streamlined (MIND-S) is a promising model of home-based dementia care coordination designed to efficiently improve person-centered outcomes, while reducing care costs...
May 18, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29782317/dementia-research-populations-progress-problems-and-predictions
#5
Sally Hunter, Nadja Smailagic, Carol Brayne
Alzheimer's disease (AD) is a clinicopathologically defined syndrome leading to cognitive impairment. Following the recent failures of amyloid-based randomized controlled trials to change the course of AD, there are growing calls for a re-evaluation of basic AD research. Epidemiology offers one approach to integrating the available evidence. Here we examine relationships between evidence from population-based, clinicopathological studies of brain aging and a range of hypotheses from all areas of AD research...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782310/putative-gonadotropin-releasing-hormone-agonist-therapy-and-dementia-an-application-of-medicare-hospitalization-claims-data
#6
Mark A Smith, Richard L Bowen, Richard Q Nguyen, George Perry, Craig S Atwood, Alfred A Rimm
BACKGROUND: Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. OBJECTIVE: To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781791/the-facilitators-and-challenges-of-dying-at-home-with-dementia-a-narrative-synthesis
#7
Caroline Mogan, Mari Lloyd-Williams, Karen Harrison Dening, Christopher Dowrick
BACKGROUND: It is reported that, given the right support, most people would prefer to die at home, yet a very small minority of people with dementia do so. At present, knowledge gaps remain on how best to support end-of-life care at home for people with dementia. AIM: To identify and understand the challenges and facilitators of providing end-of-life care at home for people with dementia. DESIGN: Narrative synthesis of qualitative and quantitative data...
June 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29780092/-multifacial-approach-of-geriatric-medicine-at-the-basic-hospital-the-first-trial-of-department-of-general-geriatric-medicine-and-dementia-medical-center-in-the-toranomon-hospital-and-the-role-of-the-geriatrician
#8
(no author information available yet)
No abstract text is available yet for this article.
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29776973/challenges-in-end-of-life-dementia-care
#9
REVIEW
Anne A Fetherston, Grace Rowley, Charlotte L Allan
Dementia is a chronic, progressive disease that is now much more widely recognised and treated. Patients with dementia may require palliative care when they reach the end stage of their illness, or they may have mild-moderate cognitive symptoms comorbid with a life-limiting illness. The variety of presentations necessitates a highly individual approach to care planning, and patients should be encouraged to set their own goals and contribute to advanced care planning where possible. Assessment and management of distressing symptoms at the end of life can be greatly helped by a detailed knowledge of the individuals' prior wishes, interdisciplinary communication and recognition of changes in presentation that may result from new symptoms, for example, onset of pain, nutritional deficits and infection...
May 18, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29772396/understanding-the-conceptualisation-of-risk-in-the-context-of-community-dementia-care
#10
Marissa Dickins, Dianne Goeman, Fleur O'Keefe, Steve Iliffe, Dimity Pond
Risk has become a ubiquitous presence in modern society. For individuals diagnosed with dementia this preoccupation with risk can affect their day-to-day life in many ways. Maintaining autonomy while balancing risks is a continual struggle not only for those living with the disease, but also their carers, family and health professionals. To understand how these different groups of individuals conceptualise the issue of risk for those living with dementia, 83 semi-structured interviews were conducted with people living with dementia, carers, older people without significant experience of dementia, and registered nurses, and staff from a community nursing organisation...
May 9, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29770579/cholinesterase-targeting-by-polyphenols-a-therapeutic-approach-for-the-treatment-of-alzheimer-s-disease
#11
REVIEW
Nasimudeen R Jabir, Fayaz Rahman Khan, Shams Tabrez
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances...
May 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29762648/a-new-framework-for-conceptualizing-symptoms-in-frontotemporal-dementia-from-animal-models-to-the-clinic
#12
Stephanie Wong, Bernard W Balleine, Fiona Kumfor
Behavioural-variant frontotemporal dementia is characterized by a number of ostensibly disparate clinical features, which have largely been considered independently. This Update proposes an integrated conceptual framework for these symptoms, by bringing together findings from animal studies, functional neuroimaging and behavioural neurology. The combined evidence indicates that many of the clinical symptoms--such as altered eating behaviour; overspending and susceptibility to scams; reduced empathy and socially inappropriate behaviour; apathy and stereotyped/ritualistic behaviour--can be conceptualized as a common underlying deficiency in goal-directed behaviour and the concomitant emergence of habits...
May 11, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29762315/effectiveness-of-psychosocial-interventions-on-the-psychological-health-and-emotional-well-being-of-family-carers-of-people-with-dementia-following-residential-care-placement-a-systematic-review
#13
Deborah Brooks, Elaine Fielding, Elizabeth Beattie, Helen Edwards, Sonia Hines
OBJECTIVE: To identify, appraise and synthesize existing evidence regarding the effectiveness of psychosocial interventions on the psychological health and emotional well-being of family carers of people with dementia who have moved into residential care. INTRODUCTION: Many carers experience stress, guilt, grief and depression following placement of a relative with dementia into residential care. Psychosocial interventions to support family carers may help to improve psychological health and emotional well-being; however, evidence for such interventions delivered to family carers following placement has yet to be appraised and synthesized...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761296/neuroimaging-in-lewy-body-dementia
#14
REVIEW
Tayyabah Yousaf, George Dervenoulas, Polytimi-Eleni Valkimadi, Marios Politis
Lewy body dementia (DLB) is a common form of cognitive impairment, accounting for 30% of dementia cases in ages over 65 years. Early diagnosis of DLB has been challenging; particularly in the context of differentiation with Parkinson's disease dementia and other forms of dementias, such as Alzheimer's disease and rapidly progressive dementias. Current practice involves the use of [123 I]FP-CIT-SPECT, [18 F]FDG PET and [123 I]MIBG molecular imaging to support diagnostic procedures. Structural imaging techniques have an essential role for excluding structural causes, which could lead to a DLB-like phenotype, as well as aiding differential diagnosis through illustrating disease-specific patterns of atrophy...
May 14, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29752254/cognitive-assessment-of-patients-with-alzheimer-s-disease-by-telemedicine-pilot-study
#15
Anna Carotenuto, Raffaele Rea, Enea Traini, Giovanna Ricci, Angiola Maria Fasanaro, Francesco Amenta
BACKGROUND: Approximately 46.8 million people are living with dementia worldwide and their number will grow in the next years. Any potential treatment should be administered as early as possible because it is important to provide an early cognitive assessment and to regularly monitor the mental function of patients. Information and communication technologies can be helpful to reach and follow patients without displacing them, but there may be doubts about the reliability of cognitive tests performed by telemedicine...
May 11, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29752034/validity-of-a-computerized-population-registry-of-dementia-based-on-clinical-databases
#16
J Mar, A Arrospide, M Soto-Gordoa, M Machón, Á Iruin, P Martinez-Lage, A Gabilondo, F Moreno-Izco, A Gabilondo, L Arriola
INTRODUCTION: The handling of information through digital media allows innovative approaches for identifying cases of dementia through computerized searches within the clinical databases that include systems for coding diagnoses. The aim of this study was to analyze the validity of a dementia registry in Gipuzkoa based on the administrative and clinical databases existing in the Basque Health Service. METHODS: This is a descriptive study based on the evaluation of available data sources...
May 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29751937/beyond-thiamine-treatment-for-cognitive-impairment-in-korsakoff-s-syndrome
#17
REVIEW
Justin M Johnson, Valerie Fox
BACKGROUND: Wernicke's encephalopathy is a condition whose treatment many consultation-liaison psychiatrists know quite well. Less clear, however, is the treatment of its dementia disorder descendent, the Korsakoff's syndrome (KS). OBJECTIVE: This article seeks to review treatment options and provide recommendations for consultation-liaison psychiatrists treating cognitive impairment in KS. METHODS: In this nonsystematic review, we reviewed PubMed, CINAHL Plus, and Google Scholar for published reports and studies regarding treatment of KS...
March 27, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29747721/longitudinal-changes-in-quality-of-life-among-elderly-people-with-and-without-dementia
#18
A E Ydstebø, S Bergh, G Selbæk, J Šaltytė Benth, K Brønnick, C Vossius
ABSTRACTObjective:To study longitudinal changes in the quality of life (QoL) in persons with and without dementia, and explore the factors associated with baseline QoL and changes of QoL over the follow-up period. DESIGN: Prospective longitudinal study. SETTING: Data were collected from 17 municipalities in Norway in the period from January 2009 to August 2012. A total of 412 persons were included, 254 (61.7 %) persons without dementia and 158 (38.3 %) with dementia at baseline...
May 11, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29747475/in-silico-investigation-of-the-pharmacological-mechanisms-of-beneficial-effects-of-ginkgo-biloba-l-on-alzheimer-s-disease
#19
Hongxiang Li, Xiaoyuan Sun, Fan Yu, Lijia Xu, Jianhua Miu, Peigen Xiao
Based on compelling experimental and clinical evidence, Ginkgo biloba L. exerts a beneficial effect in ameliorating mild to moderate dementia in patients with Alzheimer’s disease (AD) and other neurological disorders, although the pharmacological mechanisms remain unknown. In the present study, compounds, their putative target proteins identified using an inverse docking approach, and clinically tested AD-related target proteins were systematically integrated together with applicable bioinformatics methods in silico ...
May 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29744950/the-idemcare-study-improving-dementia-care-in-black-african-and-caribbean-groups-a-feasibility-cluster-randomised-controlled-trial
#20
REVIEW
Moïse Roche, Naaheed Mukadam, Simon Adelman, Gill Livingston
OBJECTIVE: We evaluated the feasibility and acceptability of a tailored evidence-based intervention, consisting of a leaflet and a letter, to encourage timely help-seeking for dementia in Black elders. METHODS: Participating GP surgeries were randomised to send either the intervention or a control leaflet about ageing well to Black patients aged ≥50 years old without known dementia. We interviewed patients 2 weeks later about the intervention's acceptability using closed and open-ended questions, and they completed a Theory-of-Planned-behaviour questionnaire about what they would do if they developed memory problems, which they also completed 4 months later...
May 9, 2018: International Journal of Geriatric Psychiatry
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