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https://www.readbyqxmd.com/read/28930751/dementia-predicting-cognitive-risk-score-and-its-correlation-with-cortical-thickness-in-parkinson-disease
#1
Byoung Seok Ye, Seun Jeon, Jee Hyun Ham, Jae Jung Lee, Jong Min Lee, Hye Sun Lee, Phil Hyu Lee, Young H Sohn
BACKGROUND: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. METHODS: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk...
September 21, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28930593/precision-medicine-of-frontotemporal-dementia-from-genotype-to-phenotype
#2
Xiang-Qian Che, Ning Song, Ying Gao, Ru-Jing Ren, Gang Wang
Frontotemporal dementia (FTD) is the second most common neurodegenerative  cause of early-onset dementia. FTD has an important genetic component contributing to its pathogenic mechanisms. Currently, extensive research on neuroimaging biomarkers and neurochemical biomarkers in FTD is being conducted to address the clinical need for a sensitive and specific diagnostic marker. Here, we review the advances in genetics, biomarkers and treatment of FTD and how this may represent a shift towards precision medicine...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930543/eeg-and-erp-biomarkers-of-alzheimer-s-disease-a-critical-review
#3
Andras Horvath, Anna Szucs, Gabor Csukly, Anna Sakovics, Gabor Stefanics, Anita Kamondi
Here we critically review studies that used electroencephalography (EEG) or event-related potential (ERP) indices as a biomarker of Alzheimer's disease. In the first part we overview studies that relied on visual inspection of EEG traces and spectral characteristics of EEG. Second, we survey analysis methods motivated by dynamical systems theory (DST) as well as more recent network connectivity approaches. In the third part we review studies of sleep.  Next, we compare the utility of early and late ERP components in dementia research...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929901/the-dementia-friendly-emergency-department-an-innovation-to-reducing-incompatibilities-at-the-local-level
#4
Belinda Parke, Kathleen F Hunter
Emergency Departments (EDs) are an integral part of the Canadian healthcare system. Older people living with dementia challenge EDs. They have complex health profiles that pose multiple challenges for staff. The current one-size-fits-all approach that aids efficiency in a technologically dependent hospital setting may not always serve older people living with dementia, their caregivers, or staff well. The premise that older people living with dementia are a problem for Canadian EDs must be reconsidered. Understanding the complexity of the situation is aided by the dementia-friendly ED framework...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28927945/consensus-approaches-to-identify-incident-dementia-in-cohort-studies-systematic-review-and-approach-in-the-successful-aging-after-elective-surgery-study
#5
REVIEW
Eyal Y Kimchi, Tammy T Hshieh, Ray Guo, Bonnie Wong, Margaret O'Connor, Edward R Marcantonio, Eran D Metzger, Jason Strauss, Steven E Arnold, Sharon K Inouye, Tamara G Fong
OBJECTIVES: To survey the current methods used to ascertain dementia and mild cognitive impairment (MCI) in longitudinal cohort studies, to categorize differences in approaches and to identify key components of expert panel methodology in current use. METHODS: We searched PubMed for the past 10 years, from March 6, 2007 to March 6, 2017 using a combination of controlled vocabulary and keyword terms to identify expert panel consensus methods used to diagnose MCI or dementia in large cohort studies written in English...
September 16, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28924872/-alzheimer-s-disease-from-auguste-deter-to-the-present-progress-disappointments-and-open-questions
#6
REVIEW
Johannes Pantel
AIM: The present article aims to provide a short overview of the discovery history, conceptual development, as well as on current neurobiological and pharmacological research questions in the field of Alzheimer's disease (AD). In view of the long hoped for but so far unachieved therapeutic breakthrough, this also includes a critical reflection of current research paradigms. MATERIAL AND METHODS: Starting from the first case report described by Alois Alzheimer in 1906, the historical impact of his seminal discovery is reconstructed...
September 18, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28923160/applying-the-neurodynamics-of-emotional-circular-causalities-in-psychosocial-and-cognitive-therapy-using-multi-sensory-environments-an-orbde-case-study-analysis
#7
Janice Ryan
This exploratory, evidence-based practice research study focuses on presenting a plausible mesoscopic brain dynamics hypothesis for the benefits of treating clients with psychosocial and cognitive challenges using a mindful therapeutic approach and multi-sensory environments. After an extensive neuroscientific review of the therapeutic benefits of mindfulness, a multi-sensory environment is presented as a window of therapeutic opportunity to more quickly and efficiently facilitate the neurobiological experience of becoming more mindful or conscious of self and environment...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28922291/population-based-models-of-planning-for-palliative-care-in-older-people
#8
David C Currow, Jane Phillips, Meera Agar
PURPOSE OF REVIEW: Health service planning requires demographic, clinical, and health systems data and is unique to each health system. Planning for palliative care in older people must include patients and their carers. This review explores literature from the last 24 months. RECENT FINDINGS: The proportion of people living in skilled nursing facilities is increasing and many residents require quality palliative care. Simultaneously, the complexity of care for older people is also increasing...
September 16, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28922189/acr-acnm-practice-parameter-for-the-performance-of-dopamine-transporter-dat-single-photon-emission-computed-tomography-spect-imaging-for-movement-disorders
#9
Rathan M Subramaniam, Kirk A Frey, Christopher H Hunt, Gustavo A Mercier, Lilja B Solnes, Patrick M Colletti, Yang Lu, Bital Savir-Baruch, Hadyn T Williams
This American College of Radiology and American College of Nuclear Medicine joint clinical practice parameter is for performance of dopamine transporter single photon emission computed tomography (SPECT) imaging, for patients with movement disorders. Parkinsonian syndrome (PS) consists of a group of neurodegenerative diseases including Parkinson disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB). Accurate diagnosis of PS is critical for clinical management...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28918818/the-dementias-a-review-and-a-call-for-a-disaggregated-approach
#10
Tobias Haeusermann
No abstract text is available yet for this article.
August 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28914217/-unexplained-behaviour-and-dementia
#11
C M P M Hertogh, J Klijnman, J F Bastiaans
Behavioural changes, often resulting in negative or challenging behaviour, are highly prevalent in patients with dementia. Here we describe two patients in whom challenging behaviour was the first sign of an evolving dementia process. We discuss the relevance of a multifactorial approach in analysis and treatment, starting from a biopsychosocial model of behaviour in dementia. One pitfall is underestimating the contribution of physical co-morbidity to challenging behaviour in these patients; a further pitfall is the 'attribution phenomenon', i...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28914089/art-museum-based-intervention-to-promote-emotional-well-being-and-improve-quality-of-life-in-people-with-dementia-the-artemis-project
#12
Arthur Schall, Valentina A Tesky, Ann-Katrin Adams, Johannes Pantel
ARTEMIS (ART Encounters: Museum Intervention Study) is an art-based intervention designed especially for people with dementia and their care partners that involves a combination of museum visits and artistic activity. This paper reports the results of a randomized wait-list controlled study on the influence of the ARTEMIS intervention on the emotional state, well-being, and quality of life of dementia patients. People with mild-to-moderate dementia (n = 44) and their care partners (n = 44) visited the Frankfurt Städel Museum once a week on six pre-arranged occasions...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28912709/extending-xnat-platform-with-an-incremental-semantic-framework
#13
Santiago Timón, Mariano Rincón, Rafael Martínez-Tomás
Informatics increases the yield from neuroscience due to improved data. Data sharing and accessibility enable joint efforts between different research groups, as well as replication studies, pivotal for progress in the field. Research data archiving solutions are evolving rapidly to address these necessities, however, distributed data integration is still difficult because of the need of explicit agreements for disparate data models. To address these problems, ontologies are widely used in biomedical research to obtain common vocabularies and logical descriptions, but its application may suffer from scalability issues, domain bias, and loss of low-level data access...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28912672/maximizing-the-potential-of-longitudinal-cohorts-for-research-in-neurodegenerative-diseases-a-community-perspective
#14
Catherine J Moody, Derick Mitchell, Grace Kiser, Dag Aarsland, Daniela Berg, Carol Brayne, Alberto Costa, Mohammad A Ikram, Gail Mountain, Jonathan D Rohrer, Charlotte E Teunissen, Leonard H van den Berg, Joanna M Wardlaw
Despite a wealth of activity across the globe in the area of longitudinal population cohorts, surprisingly little information is available on the natural biomedical history of a number of age-related neurodegenerative diseases (ND), and the scope for intervention studies based on these cohorts is only just beginning to be explored. The Joint Programming Initiative on Neurodegenerative Disease Research (JPND) recently developed a novel funding mechanism to rapidly mobilize scientists to address these issues from a broad, international community perspective...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28910367/a-novel-panel-of-%C3%AE-synuclein-antibodies-reveal-distinctive-staining-profiles-in-synucleinopathies
#15
Jess-Karan S Dhillon, Cara Riffe, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Todd E Golde, Benoit I Giasson
Synucleinopathies are a spectrum of neurodegenerative diseases characterized by the intracellular deposition of the protein α-synuclein leading to multiple outcomes, including dementia and Parkinsonism. Recent findings support the notion that across the spectrum of synucleinopathies there exist diverse but specific biochemical modifications and/or structural conformations of α-synuclein, which would give rise to protein strain specific prion-like intercellular transmission, a proposed model that could explain synucleinopathies disease progression...
2017: PloS One
https://www.readbyqxmd.com/read/28906268/new-pet-markers-for-the-diagnosis-of-dementia
#16
Pierre Payoux, Anne Sophie Salabert
PURPOSE OF REVIEW: To present the new PET markers that could become in the coming years, relevant to advanced clinical approaches to dementia diagnosis, drug trials, and treatment strategies and discuss their advantages and limitations. RECENT FINDINGS: The most advanced new PET tracers are the markers of the amyloid plaques, the τ compounds and the tracers of the translocator protein as markers of neuroinflammation. The main advantages but also the weaknesses of each of these markers are discussed...
September 12, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28905649/participatory-arts-programs-in-residential-dementia-care-playing-with-language-differences
#17
Aagje Swinnen, Kate de Medeiros
This article examines connections between language, identity, and cultural difference in the context of participatory arts in residential dementia care. Specifically, it looks at how language differences become instruments for the language play that characterizes the participatory arts programs, TimeSlips and the Alzheimer's Poetry Project. These are two approaches that are predominantly spoken-word driven. Although people living with dementia experience cognitive decline that affects language, they are linguistic agents capable of participating in ongoing negotiation processes of connection, belonging, and in- and exclusion through language use...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28902409/binswanger-s-disease-biomarkers-in-the-inflammatory-form-of-vascular-cognitive-impairment-and-dementia
#18
REVIEW
Gary A Rosenberg
Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer's disease. VCID is a heterogeneous group of diseases for which there are no proven treatments. Biomarkers can be used to select more homogeneous populations. Small vessel disease is the most prevalent form of VCID and is the optimal form for treatment trials because there is a progressive course with characteristic pathological changes...
September 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28901562/involving-institutionalised-people-with-dementia-in-their-care-planning-meetings-lessons-learnt-by-the-staff
#19
Feliciano Villar, Montserrat Celdrán, Josep Vila-Miravent, Rodrigo Serrat
BACKGROUND: Applying a person-centred care (PCC) approach is an aspiration for many services attending people with dementia (PwD). However, the implementation and assessment of PCC practices represent a challenge to health professionals. AIM: To evaluate the impact on staff of a programme aiming to involve people with dementia (PwD) in their individualised care-planning (ICP) meetings in long-term residential settings; specifically, to explore the lessons that staff perceived they had learned from the experience...
September 13, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28899416/alzheimer-s-disease-prevention-from-risk-factors-to-early-intervention
#20
REVIEW
Marta Crous-Bou, Carolina Minguillón, Nina Gramunt, José Luis Molinuevo
Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a healthcare burden of epidemic proportions for which there is currently no cure. Disappointing results from clinical trials performed in mild-moderate AD dementia combined with clear epidemiological evidence on AD risk factors are contributing to the development of primary prevention initiatives. In addition, the characterization of the long asymptomatic stage of AD is allowing the development of intervention studies and secondary prevention programmes on asymptomatic at-risk individuals, before substantial irreversible neuronal dysfunction and loss have occurred, an approach that emerges as highly relevant...
September 12, 2017: Alzheimer's Research & Therapy
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