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https://www.readbyqxmd.com/read/28064147/experimental-and-theoretical-studies-on-stability-of-new-stabilizers-for-n-methyl-p-nitroaniline-derivative-in-cmdb-propellants
#1
Qiufan Tang, Xuezhong Fan, Jizhen Li, Fuqiang Bi, Xiaolong Fu, Lianjie Zhai
Although N-methyl-P-nitroaniline (MNA) was a quite effective stabilizer in composite modified double base (CMDB) propellants, it undergoes crystallization easily from nitroglycerin (NG) during storage. In order to improve its solubility in nitroglycerin (NG) and the stability in propellants, several new stabilizers including N-ethyl-p-nitroaniline (ENA), N-n-propyl-p-nitroaniline (n-PNA), N-i-propyl-p-nitroaniline (i-PNA), N-n-butyl-p-nitroaniline (n-BNA) and N-t-butyl-p-nitroaniline (t-BNA) were designed and synthesized to replace MNA by increasing the carbon chain length...
December 28, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28063514/undernutrition-as-independent-predictor-of-early-mortality-in%C3%A2-elderly-cancer-patients
#2
Renata B Martucci, Mariana V Barbosa, Cristiane A D'Almeida, Viviane D Rodrigues, Anke Bergmann, Nivaldo B de Pinho, Luiz Claudio S Thuler
OBJECTIVES: The aim of this study was to evaluate the 1-y survival of elderly patients with cancer and the association between undernutrition and mortality. METHODS: This was a cohort study with elderly patients ages ≥65 y admitted between September and October 2014. A nutritionist performed a Mini Nutritional Assessment-Short Form (MNA-SF) assessment during 48 h of hospital admission and collected data about potential confounding variables (comorbidities, stage of cancer, treatment in the previous 3 mo, and reason for hospitalization)...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28049443/performance-of-edmonton-frail-scale-on-frailty-assessment-its-association-with-multi-dimensional-geriatric-conditions-assessed-with-specific-screening-tools
#3
Simone Perna, Matthew D'Arcy Francis, Chiara Bologna, Francesca Moncaglieri, Antonella Riva, Paolo Morazzoni, Pietro Allegrini, Antonio Isu, Beatrice Vigo, Fabio Guerriero, Mariangela Rondanelli
BACKGROUND: The aim of this study was to evaluate the performance of Edmonton Frail Scale (EFS) on frailty assessment in association with multi-dimensional conditions assessed with specific screening tools and to explore the prevalence of frailty by gender. METHODS: We enrolled 366 hospitalised patients (women\men: 251\115), mean age 81.5 years. The EFS was given to the patients to evaluate their frailty. Then we collected data concerning cognitive status through Mini-Mental State Examination (MMSE), health status (evaluated with the number of diseases), functional independence (Barthel Index and Activities Daily Living; BI, ADL, IADL), use of drugs (counting of drugs taken every day), Mini Nutritional Assessment (MNA), Geriatric Depression Scale (GDS), Skeletal Muscle Index of sarcopenia (SMI), osteoporosis and functionality (Handgrip strength)...
January 4, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28033549/combined-iron-and-sulfate-reduction-biostimulation-as-a-novel-approach-to-enhance-btex-and-pah-source-zone-biodegradation-in-biodiesel-blend-contaminated-groundwater
#4
Juliana B Müller, Débora T Ramos, Catherine Larose, Marilda Fernandes, Helen S C Lazzarin, Timothy M Vogel, Henry X Corseuil
The use of biodiesel as a transportation fuel and its growing mandatory blending percentage in diesel increase the likelihood of contaminating groundwater with diesel/biodiesel blends. A 100L-field experiment with B20 (20% biodiesel and 80% diesel, v/v) was conducted to assess the potential for the combined biostimulation of iron and sulfate reducing bacteria to enhance BTEX and PAH biodegradation in a diesel/biodiesel blend-contaminated groundwater. A B20 field experiment under monitored natural attenuation (MNA) was used as a baseline control...
December 5, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28031994/covariation-between-plasma-phosphate-and-daytime-cortisol-in-early-parkinson-s-disease
#5
Lena Håglin, Lennart Bäckman
BACKGROUND: Disturbed phosphate homeostasis in early Parkinson's disease (PD) may originate from a stress-related condition and nutritional status among other risk factors, age, and gender. METHODS: Risk of malnutrition using Mini-nutritional assessment (MNA score) and plasma levels of protein markers and daytime cortisol at the time of diagnosis in PD (n = 75) were compared with a control group (n = 24). Cognition was assessed using the Mini-Mental State Examination (MMSE score) and motor function using Unified Parkinson's Disease Rating Scale (UPDRS-part III scale)...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28000247/investigation-of-nutritional-status-using-the-mini-nutritional-assessment-short-form-and-analysis-of-the-relevant-factors-in-patients-with-head-and-neck-tumour
#6
Ayaka Yanagi, Mai Murase, Yuka I Sumita, Hisashi Taniguchi
OBJECTIVE: The aims of this study were to reveal the nutritional status of patients after head and neck tumour treatment by using the Mini Nutritional Assessment-Short Form (MNA-SF) and to analyse the factors affecting nutritional status in patients with head and neck tumour. BACKGROUND: Elderly patients with loss of teeth and maxillary/mandibular bone due to head and neck tumour treatment could be at high risk of malnutrition. However, there are few reports on the nutritional status of these patients...
December 20, 2016: Gerodontology
https://www.readbyqxmd.com/read/27999853/nutritional-follow-up-after-discharge-prevents-readmission-to-hospital-a-randomized-clinical-trial
#7
J Lindegaard Pedersen, P U Pedersen, E M Damsgaard
OBJECTIVE: To compare the effects of two individualized nutritional follow-up intervention strategies (home visit or telephone consultation) with no follow-up, with regard to acute readmissions to hospital at two points in time, 30 and 90 days after discharge from hospital. DESIGN: Randomized clinical trial with two intervention groups and one control group, and monitoring on readmission at 30 and 90 days after discharge. SETTING: Intervention in the participants' homes after discharge from hospital...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27999846/comparison-of-nutritional-status-in-the-elderly-according-to-living-situations
#8
O Kucukerdonmez, S Navruz Varli, E Koksal
AIM: This study aimed to evaluate the nutritional status of elderly individuals living alone and with their families. PARTICIPANTS AND METHOD: The sample of the study included 872 elderly individuals who agreed to participate in the study, were aged 65 or over, and lived in Ankara. The data were gathered from a survey, using face-to-face interviews. The Mini Nutritional Assessment (MNA) was used in evaluating each individual's nutrition. RESULTS: The rate of malnutrition in the study population was 5% while the malnutrition risk was 67%...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27928120/effect-of-long-term-proton-pump-inhibitor-therapy-on-nutritional-status-in-elderly-hospitalized-patients
#9
Mariko Nakamichi, Hidetaka Wakabayashi
The purpose was to investigate the association between proton pump inhibitor (PPI) therapy and nutritional status in elderly hospitalized patients. Participants were 190 elderly patients admitted to the long-term care wards, convalescence rehabilitation wards, and community integrated care wards in January 2015. Nutritional status was assessed using the mini nutritional assessment short-form (MNA-SF). The PPI use group was compared with the PPI non-use group regarding nutrition status. Logistic regression analysis was used to examine whether the period of PPI therapy was associated independently with malnutrition following adjustment for covariates including gender, age, and serum albumin level...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27925144/nutrition-screening-practices-amongst-australian-residential-aged-care-facilities
#10
J Kellett, G Kyle, C Itsiopoulos, M Naunton
OBJECTIVES: To determine the proportion of Residential Aged Care Facilities (RACFs) in Australia who use a nutrition screening tool on residents to identify those at risk of malnutrition, and to review practice following identification of residents as being at high risk of malnutrition. DESIGN: Multi-center, cross sectional observational study. SETTING: Residential Aged Care Facilities. PARTICIPANTS: The Director of Nursing at each site was contacted by telephone and asked questions relating to current nutrition screening practices at their residential aged care facility...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27919768/proximal-femoral-fractures-in-centenarians-a-retrospective-analysis-of-39-patients
#11
A Morice, N Reina, G Gracia, P Bonnevialle, J-M Laffosse, K Wytrykowski, E Cavaignac, N Bonnevialle
BACKGROUND: A corollary of the current population ageing in France is an increase in proximal femoral fractures (PFFs), particularly among centenarians. The outcomes of PFFs in centenarians in France are unknown. We therefore conducted a retrospective study of centenarians with PFFs both to assess: (1) assess clinical outcomes according to geriatric and trauma scores, (2) and to determine whether routine surgery is warranted. HYPOTHESIS: Morbidity and mortality in a single-centre cohort of centenarians with surgically treated PFFs are consistent with previous reports...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27919767/internal-fixation-of-intra-capsular-proximal-femoral-fractures-in-patients-older-than-80-years-still-relevant-multivariate-analysis-of-a-prospective-multicentre-cohort
#12
N Reina, P Bonnevialle, B Rubens Duval, P Adam, F Loubignac, T Favier, P Massin
BACKGROUND: Arthroplasty is now widely used to treat intra-capsular proximal femoral fractures (PFFs) in older patients, even when there is little or no displacement. However, whether arthroplasty is associated with lower mortality and complication rates in non-displaced or mildly displaced PFFs is unknown. The objectives of this prospective study were: (1) to evaluate early mortality rates with the two treatment methods, (2) to identify risk factors for complications, (3) and to identify predictors of functional decline...
December 2, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27914325/fabrication-of-metronidazole-loaded-poly-%C3%AE%C2%B5-caprolactone-zein-core-shell-nanofiber-membranes-via-coaxial-electrospinning-for-guided-tissue-regeneration
#13
Min He, Huiyi Jiang, Rui Wang, Yi Xie, Changsheng Zhao
To develop a biologically mimetic guided tissue regeneration (GTR) membrane with localized sustained drug release function to prevent infection, coaxial electrospinning technique was conducted to fabricate metronidazole (MNA)-loaded poly (ε-caprolactone) (PCL)/zein core/shell nanofibers. The nanofibers displayed a uniform bead-free round morphology as observed by scanning electron microscopy (SEM), and a core/shell structure as confirmed by transmission electron microscopy (TEM). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) characterizations demonstrated that the MNA was well dispersed in the nanofibers matrix...
November 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27893697/morbidity-and-mortality-predictivity-of-nutritional-assessment-tools-in-the-postoperative-care-unit
#14
Şule Özbilgin, Volkan Hanc, Dilek Ömür, Mücahit Özbilgin, Mine Tosun, Serhan Yurtlu, Semih Küçükgüçlü, Atalay Arkan
The aim was to evaluate the nutritional situation of patients admitted to the Postoperative Acute Care Unit using classic methods of objective anthropometry, systemic evaluation methods, and Nutrition Risk in Critically Ill (NUTRIC) score, and to compare them as a predictor of morbidity and mortality.At admission to the postoperative care unit, patients undergoing various surgeries were assessed for the following items: Subjective Global Assessment (SGA), Nutritional Risk Index (NRI), Nutritional Risk Screening (NRS)-2002, Mini Nutritional Assessment (MNA), Charlson comorbidity index (CCI), and NUTRIC score, anthropometric measurements, serum total protein, serum albumin, and lymphocyte count...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890621/nasal-drug-delivery-design-of-a-novel-mucoadhesive-and-in-situ-gelling-polymer
#15
Claudia Menzel, Max Jelkmann, Flavia Laffleur, Andreas Bernkop-Schnürch
The aim of the present study was to establish a novel polymeric excipient for liquid nasal dosage forms exhibiting viscosity increasing properties, improved mucoadhesion and stability towards oxidation in solution. In order to achieve this goal, 2-mercaptonicotinic acid was first coupled to l-cysteine by disulfide exchange reaction and after purification directly attached to the polymeric backbone of xanthan gum by carbodiimide mediated amide bond formation. The resulting conjugate was characterized with respect to the amount of coupled ligand, the in situ gelling behavior, mucoadhesive properties and stability towards oxidation...
November 24, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27887891/high-intake-of-nonmilk-extrinsic-sugars-is-associated-with-protein-and-micronutrient-dilution-in-home-dwelling-and-institutionalized-older-people
#16
Satu K Jyväkorpi, Kaisu H Pitkälä, Taija M Puranen, Mikko P Björkman, Hannu Kautiainen, Timo E Strandberg, Helena Soini, Merja H Suominen
BACKGROUND: High dietary sugar intake may compromise protein and micronutrient intakes in people with low energy intakes. The results of micronutrient dilution studies in older people have been few and conflicting. We examined the nutritional status and nutrient intakes associated with nonmilk extrinsic sugars (NMES) intakes in older people representing a broad spectrum of both healthy and vulnerable older populations. DESIGN AND PARTICIPANTS: This cross-sectional study combined five Finnish data sets covering home-dwelling (n = 526) and institutionalized (n = 374) older people...
November 22, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27883167/frailty-is-a-geriatric-syndrome-characterized-by-multiple-impairments-a-comprehensive-approach-is-needed
#17
L-K Chen, A-C Hwang, L-K Liu, W-J Lee, L-N Peng
OBJECTIVE: To evaluate the prevalence of frailty and the associated multimorbidity and functional impairments among community-dwelling middle-aged and elderly people in Taiwan. DESIGN: a cross-sectional study. SETTING: communities in I-Lan County of Taiwan. PARTICIPANTS: 1839 community-dwelling people aged 50 years and older. INTERVENTION: None. MEASUREMENTS: Frailty defined by Fried's criteria, Charlson's comorbidity index (CCI), Functional Autonomy Measurement System (SMAF), Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Nutrition Assessment (MNA), Mini-Mental State Examination (MMSE), and Short Form-12 quality of life questionnaire...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27879669/synthesis-of-a-morpholino-nucleic-acid-mna-uridine-phosphoramidite-and-exon-skipping-using-mna-2-o-methyl-mixmer-antisense-oligonucleotide
#18
Suxiang Chen, Bao T Le, Kamal Rahimizadeh, Khalil Shaikh, Narinder Mohal, Rakesh N Veedu
In this study, we synthesised a morpholino nucleoside-uridine (MNA-U) phosphoramidite and evaluated the potential of a MNA-modified antisense oligonucleotide (AO) sequences to induce exon 23 skipping in mdx mouse myotubes in vitro towards extending the applicability of morpholino chemistry with other nucleotide monomers. We designed, synthesised, and compared exon skipping efficiencies of 20 mer MNA-modified 2'-O-methyl RNA mixmer AO on a phosphorothioate backbone (MNA/2'-OMePS) to the corresponding fully modified 2'-O-methyl RNA AO (2'-OMePS) as a control...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27853883/nutritional-status-and-its-effects-on-muscle-wasting-in-patients-with-chronic-heart-failure-insights-from-studies-investigating-co-morbidities-aggravating-heart-failure
#19
Masakazu Saitoh, Marcelo Rodrigues Dos Santos, Nicole Ebner, Amir Emami, Masaaki Konishi, Junichi Ishida, Miroslava Valentova, Anja Sandek, Wolfram Doehner, Stefan D Anker, Stephan von Haehling
BACKGROUND: Inadequate nutritional status has been linked to poor outcomes in patients with heart failure (HF). Skeletal muscle wasting affects about 20% of ambulatory patients with HF. The impact of nutritional intake and appetite on skeletal muscle wasting has not been investigated so far. We sought to investigate the impact of nutritional status on muscle wasting and mortality in ambulatory patients with HF. METHODS: We studied 130 ambulatory patients with HF who were recruited as a part of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF) program...
December 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27792245/malnutrition-and-risk-of-structural-brain-changes-seen-on-magnetic-resonance-imaging-in-older-adults
#20
Marian A E de van der Schueren, Sabine Lonterman-Monasch, Wiesje M van der Flier, Mark H Kramer, Andrea B Maier, Majon Muller
OBJECTIVES: To study the associations between protein energy malnutrition, micronutrient malnutrition, brain atrophy, and cerebrovascular lesions. DESIGN: Cross-sectional. SETTING: Geriatric outpatient clinic. PARTICIPANTS: Older adults (N = 475; mean age 80 ± 7). MEASUREMENTS: Nutritional status was assessed using the Mini Nutritional Assessment (MNA) and according to serum micronutrient levels (vitamins B1, B6, B12, D; folic acid)...
December 2016: Journal of the American Geriatrics Society
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