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https://www.readbyqxmd.com/read/29157816/effect-of-ipomoea-aquatica-ethanolic-extract-in-streptozotocin-stz-induced-diabetic-rats-via-1-h-nmr-based-metabolomics-approach
#1
Azliana Abu Bakar Sajak, Ahmed Mediani, Maulidiani, Nur Sumirah Mohd Dom, Chandradevan Machap, Muhajir Hamid, Amin Ismail, Alfi Khatib, Faridah Abas
BACKGROUND: Ipomoea aquatica (locally known as "kangkung") has previously been reported to have hypoglycemic activities on glucose level in diabetes patients. However, the effect of I. aquatica ethanolic extract on the metabolites in the body has remained unknown. PURPOSE: This study provides new insights on the changes of endogenous metabolites caused by I. aquatica ethanolic extract and improves the understanding on the therapeutic efficacy and mechanism of I...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29155147/selective-and-membrane-permeable-small-molecule-inhibitors-of-nicotinamide-n-methyltransferase-reverse-high-fat-diet-induced-obesity-in-mice
#2
Harshini Neelakantan, Virginia Vance, Michael D Wetzel, Hua-Yu Leo Wang, Stanton F McHardy, Celeste C Finnerty, Jonathan D Hommel, Stanley J Watowich
There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities. A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis. To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors...
November 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29151305/comparison-of-nutritional-risk-screening-tools-for-predictingsarcopenia-in-hospitalized-patients
#3
(no author information available yet)
Background/aim: The aim of this study was to assess the risk of malnutrition in hospitalized patients with three different tests and to compare these tests in terms of long hospitalization periods and sarcopenia. Materials and methods: Hospitalized patients in an internal medicine clinic were enrolled in this cross-sectional study. Patients were grouped as under 65 years (Group 1 = G1) and over 65 years old (Group 2 = G2). The nutritional status of the patients was evaluated with the Nutritional Risk Screening (NRS) 2002, Universal Malnutrition Screening Tool (MUST), Mini Nutritional Assessment Short Form (MNA-SF), and total Mini Nutritional Assessment (MNA) tests...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29145472/replacing-methyl-bromide-with-a-combination-of-1-3-dichloropropene-and-metam-sodium-for-cucumber-production-in-china
#4
Liangang Mao, Hongyun Jiang, Lan Zhang, Yanning Zhang, Muhammad Umair Sial, Haitao Yu, Aocheng Cao
The combination of 1,3-dichloropropene (1,3-D) and metam sodium (MNa) is a potential resource to replace methyl bromide (MB) as a soil fumigant. The efficacy of 1,3-D+MNa as a crucial factor to limit soil-borne pests was evaluated in one laboratory experiment and two cucumber greenhouse studies conducted in commercial operations. Laboratory results revealed that 1,3-D and MNa (10+20 mg a.i. kg-1 soil) provided the best complementary control of the root-knot nematode, Fusarium oxysporum and two species of weed seeds...
2017: PloS One
https://www.readbyqxmd.com/read/29132738/impact-of-implant-supported-prostheses-on-nutritional-status-and-oral-health-perception-in-edentulous-patients
#5
Nada El Osta, Lana El Osta, Farah Moukaddem, Tatiana Papazian, Robert Saad, Martine Hennequin, Lydia Rabbaa Khabbaz
BACKGROUND & AIMS: Improvement of nutritional status and perception of oral health are supposed to be different with complete conventional denture or implant-supported fixed or removable prostheses. Since no study has been conducted in Lebanon, the aim of our study was to assess the nutritional status and oral heath related quality of life (OHRQoL) in totally edentulous patients after treatment with complete denture or implant supported-prostheses. MATERIAL AND METHODS: This was an observational clinical prospective study...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29130705/disability-and-its-influence-in-nutritional-assessment-tools-in-elderly-people-living-in-nursing-homes
#6
Beatriz Lardiés-Sánchez, Alejandro Sanz-París, Javier Pérez-Nogueras, Antonio Serrano-Oliver, María Elena Torres-Anoro, María Dolores Ballesteros-Pomar
INTRODUCTION: Poor nutritional status is associated with increased morbidity and mortality, especially in older people. OBJECTIVE: The aim of this study was to assess nutritional status in elderly nursing home residents with different nutritional test, and to determine which parameters used for nutritional assessment can be carried out in this population, which usually have a high prevalence of functionally dependent residents. METHODS: A cross-sectional study was performed in 383 elderly...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29129784/impact-of-prosthodontic-rehabilitation-on-the-masticatory-performance-of-partially-dentate-older-patients-can-it-predict-nutritional-state-results-from-a-rct
#7
Sara Wallace, Stefanie Samietz, Meriem Abbas, Gerald McKenna, Jayne V Woodside, Martin Schimmel
OBJECTIVES: With a decreased number of teeth, a reduction in chewing function can contribute to changes in food choices and ultimately impact on overall nutritional status. This study compared the impact of two tooth replacement strategies for partially dentate older patients on masticatory performance and nutritional status. METHODS: Patients aged 65 years and older were randomly allocated to two different treatment groups. For the RPDP-group (removable partial dental prostheses) each participant was restored to complete dental arches with cobalt-chromium removable prostheses...
November 10, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29118612/distributional-records-of-antarctic-and-sub-antarctic-ophiuroidea-from-samples-curated-at-the-italian-national-antarctic-museum-mna-check-list-update-of-the-group-in-the-terra-nova-bay-area-ross-sea-and-launch-of-the-mna-3d-model-virtual-gallery
#8
Matteo Cecchetto, Maria Chiara Alvaro, Claudio Ghiglione, Alice Guzzi, Claudio Mazzoli, Paola Piazza, Stefano Schiaparelli
The distributional records of Ophiuroidea stored at the Italian National Antarctic Museum (MNA, Section of Genoa) are presented, corresponding to 1595 individuals that belong to 35 species and 17 genera. Specimens were collected in 106 different sampling stations at depths ranging from 21 to 1652 m in the framework of 14 Antarctic expeditions to the Ross Sea, one to the Antarctic Peninsula, and one to the Falkland Islands (Islas Malvinas). Three species, Amphiura joubini Koehler, 1912, Amphiura (Amphiura) angularis Lyman, 1879, and Ophiura flexibilis (Koehler, 1911), are reported as new records for the Terra Nova Bay area, whose check-list of species increases from 15 to 18 species...
2017: ZooKeys
https://www.readbyqxmd.com/read/29111098/development-of-pre-activated-%C3%AE-cyclodextrin-as-a-mucoadhesive-excipient-for-intra-vesical-drug-delivery
#9
Muhammad Ijaz, Maximilian Prantl, Noemi Lupo, Flavia Laffleur, Mulazim Hussain, Barbara Matuszczak, Andreas Bernkop-Schnürch
The study was designed to synthesize and characterize pre-activated α-cyclodextrin (α-CD) derivatives as mucus adhering excipients for intra-vesical drug delivery. Sodium periodate (NaIO4) was used to oxidize α-CD and subsequently cysteamine was covalently attached to carbonyl groups of oxidized α-CD via reductive amination to produce thiolated α-CD. L-cysteine-2-mercaptonicotinic acid conjugate (Cys-MNA) was covalently attached to carbonyl groups of oxidized α-CD to produce pre-activated α-CD having enhance stability against oxidation at higher pH...
October 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29108370/prevalence-of-malnutrition-in-patients-at-first-medical-oncology-visit-the-premio-study
#10
Maurizio Muscaritoli, Simone Lucia, Alessio Farcomeni, Vito Lorusso, Valeria Saracino, Carlo Barone, Francesca Plastino, Stefania Gori, Roberto Magarotto, Giacomo Carteni, Bruno Chiurazzi, Ida Pavese, Luca Marchetti, Vittorina Zagonel, Eleonora Bergo, Giuseppe Tonini, Marco Imperatori, Carmelo Iacono, Luigi Maiorana, Carmine Pinto, Daniela Rubino, Luigi Cavanna, Roberto Di Cicilia, Teresa Gamucci, Silvia Quadrini, Salvatore Palazzo, Stefano Minardi, Marco Merlano, Giuseppe Colucci, Paolo Marchetti
Background: In cancer patients, malnutrition is associated with treatment toxicity, complications, reduced physical functioning, and decreased survival. The Prevalence of Malnutrition in Oncology (PreMiO) study identified malnutrition or its risk among cancer patients making their first medical oncology visit. Innovatively, oncologists, not nutritionists, evaluated the nutritional status of the patients in this study. Methods: PreMiO was a prospective, observational study conducted at 22 medical oncology centers across Italy...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102322/a-systematic-review-and-meta-analysis-of-the-criterion-validity-of-nutrition-assessment-tools-for-diagnosing-protein-energy-malnutrition-in-the-older-community-setting-the-macro-study
#11
Skye Marshall, Dana Craven, Jaimon Kelly, Elizabeth Isenring
BACKGROUND & AIMS: Malnutrition is a significant barrier to healthy and independent ageing in older adults who live in their own homes, and accurate diagnosis is a key step in managing the condition. However, there has not been sufficient systematic review or pooling of existing data regarding malnutrition diagnosis in the geriatric community setting. The current paper was conducted as part of the MACRo (Malnutrition in the Ageing Community Review) Study and seeks to determine the criterion (concurrent and predictive) validity and reliability of nutrition assessment tools in making a diagnosis of protein-energy malnutrition in the general older adult community...
October 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29099635/nutritional-status-of-patients-with-chronic-obstructive-pulmonary-disease-in-relation-to-their-physical-performance
#12
Zinka Matkovic, Danijel Cvetko, Dario Rahelic, Cristina Esquinas, Marko Zarak, Marc Miravitlles, Neven Tudoric
Nutritional abnormalities and physical inactivity are highly prevalent in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to determine the association between nutritional status/body composition and physical performance in patients with COPD. A cross-sectional observational study was conducted in outpatients with clinically stable, moderate to very severe COPD. In the assessment of nutritional status, we used dual energy X-ray absorptiometry, anthropometry, serum biomarkers, and the Mini-Nutritional Assessment (MNA) questionnaire...
November 3, 2017: COPD
https://www.readbyqxmd.com/read/29095131/nutritional-and-functional-status-in-newly-hospitalized-older-patients-who-are-not-underweight
#13
Anna Kańtoch, Jolanta Wielek, Barbara Gryglewska, Tomasz Grodzicki
Although malnutrition is commonly associated with being underweight, it occurs whenever nutrient intakes are inadequate, regardless of current body weight. The aim of the study was to determine nutritional status as a predictor of functional status among older patients without underweight according to body mass index (BMI) at hospital admission. This cross-sectional study enrolled 90 patients aged ≥65 years (mean age 78.1 ± 6.4). Assessments included basic and Instrumental Activities of Daily Living (bADL, IADL), Mini Nutritional Assessment (MNA), and BMI...
November 2, 2017: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29083448/quality-indicators-of-nutritional-care-practice-in-elderly-care
#14
M Skinnars Josefsson, M Nydahl, I Persson, Y Mattsson Sydner
OBJECTIVES: The aim is to explore the effects of antecedent, structural and process quality indicators of nutritional care practice on meal satisfaction and screened nutritional status among older adults in residential care homes. DESIGN: Data for this Swedish cross-sectional study regarding older adults living in residential care homes were collected by i) a national questionnaire, ii) records from the quality registry Senior Alert, iii) data from an Open Comparison survey of elderly care in 2013/2014...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29083434/the-unhealthy-lifestyle-factors-associated-with-an-increased-risk-of-poor-nutrition-among-the-elderly-population-in-china
#15
W-Q Lin, H H X Wang, L-X Yuan, B Li, M-J Jing, J-L Luo, J Tang, B-K Ye, P-X Wang
OBJECTIVES: The associations between nutritional status and lifestyle factors have not been well established. This study aimed to investigate the prevalence of poor nutrition and to examine the relationships between nutritional status and unhealthy lifestyle and other related factors among the elderly. METHODS: This cross-sectional study was conducted in Liaobu Town, Dongguan city, China. A total of 708 community-dwelling older adults aged ≥60 years were recruited by stratified random sampling...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29080875/-application-of-molecular-descriptors-for-recognition-of-phosphorylation-sites-in-amino-acid-sequences
#16
D A Karasev, P I Savosina, B N Sobolev, D A Filimonov, A A Lagunin
Recognition of the phosphorylation sites in proteins is required for reconstruction of regulatory processes in living systems. This task is complicated because the phosphorylation motifs in amino acid sequences are considerably degenerated. To improve the prediction efficacy researchers often use additional descriptors, which should reflect physicochemical features of site-surrounding regions. We have evaluated the reasonability of this approach by applying molecular descriptors (MNA) for structural presentation of the peptide segments...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29076209/oral-health-matters-for-the-nutritional-status-of-older-persons-a-population-based-study
#17
Ulrika Lindmark, Henrik Jansson, Christina Lannering, Linda Johansson
AIM AND OBJECTIVE: The aim of this study was to explore the association between oral health and nutritional status in the context of daily care for older people. BACKGROUND: Oral problems often increase with age and affect a person's ability to chew and swallow. They might also influence the ability to maintain a satisfactory nutritional status. Oral health awareness is therefore of great importance in nursing care for older people. METHODS: Data from the Swedish quality register, Senior Alert, were used, including structured assessments of both oral and nutritional status using the Revised Oral Assessment Guide - Jönköping (ROAG-J) and the Mini Nutritional Assessment (MNA)...
October 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29069300/rosc-pred-web-service-for-rodent-organ-specific-carcinogenicity-prediction
#18
Alexey Lagunin, Anastasia Rudik, Dmitry Druzhilovsky, Dmitry Filimonov, Vladimir Poroikov
Motivation: Identification of rodent carcinogens is an important task in risk assessment of chemicals. SAR methods were proposed to reduce the number of animal experiments. Most of these methods ignore information about organ-specificity of tumorigenesis. Our study was aimed at the creation of classification models and a freely available online service for prediction of rodent carcinogens considering the species (rats, mice), sex, and tissue-specificity from structural formula of compounds...
October 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29042762/assessing-the-nutritional-status-of-hospitalized-elderly
#19
REVIEW
Nur Adilah Shuhada Abd Aziz, Nur Islami Mohd Fahmi Teng, Mohd Ramadan Abdul Hamid, Nazrul Hadi Ismail
PURPOSE: The increasing number of elderly people worldwide throughout the years is concerning due to the health problems often faced by this population. This review aims to summarize the nutritional status among hospitalized elderly and the role of the nutritional assessment tools in this issue. METHODS: A literature search was performed on six databases using the terms "malnutrition", "hospitalised elderly", "nutritional assessment", "Mini Nutritional Assessment (MNA)", "Geriatric Nutrition Risk Index (GNRI)", and "Subjective Global Assessment (SGA)"...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29033559/pressure-injuries-in-elderly-with-acute-myocardial-infarction
#20
Klara Komici, Dino F Vitale, Dario Leosco, Angela Mancini, Graziamaria Corbi, Leonardo Bencivenga, Alessandro Mezzani, Bruno Trimarco, Carmine Morisco, Nicola Ferrara, Giuseppe Rengo
OBJECTIVES: To assess pressure injury (PI) incidence among patients hospitalized for acute myocardial infarction (AMI) in an intensive coronary care unit (ICCU) and to detect the impact of specific risk factors on the development of PI in this clinical setting. PATIENTS AND METHODS: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67.5±11.5 years (n=165). Norton Scale, Mini Nutritional Assessment (MNA), demographic, clinical and biochemical data collected at the time of ICCU admission have been tested in a logistic model to assess the odds ratios (ORs) of PI risk development...
2017: Clinical Interventions in Aging
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