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https://www.readbyqxmd.com/read/28748044/visualizing-the-dental-biofilm-matrix-by-means-of-fluorescence-lectin-binding-analysis
#1
Pune N Tawakoli, Thomas R Neu, Mette M Busck, Ute Kuhlicke, Andreas Schramm, Thomas Attin, Daniel B Wiedemeier, Sebastian Schlafer
The extracellular matrix is a poorly studied, yet important component of dental biofilms. Fluorescence lectin-binding analysis (FLBA) is a powerful tool to characterize glycoconjugates in the biofilm matrix. This study aimed to systematically investigate the ability of 75 fluorescently labeled lectins to visualize and quantify extracellular glycoconjugates in dental biofilms. Lectin binding was screened on pooled supragingival biofilm samples collected from 76 subjects using confocal microscopy. FLBA was then performed with 10 selected lectins on biofilms grown in situ for 48 h in the absence of sucrose...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28731606/feasibility-of-home-based-dietetic-intervention-to-improve-the-nutritional-status-of-older-adults-post-hospital-discharge
#2
Aliza Haslinda Hamirudin, Karen Walton, Karen Charlton, Amanda Carrie, Linda Tapsell, Marianna Milosavljevic, Glen Pang, Jan Potter
AIM: To determine if a model of home-based dietetic care improves dietary intake and weight status in a specific group of older adults post-hospitalisation. METHODS: The Department of Veterans' Affairs clients aged 65 years and over were recruited from hospitals in a regional area of New South Wales, Australia (n = 32 men, n = 36 women). Nutritional status was assessed at home at baseline (within two weeks post-discharge) and three months post-discharge using a diet history, a food frequency checklist and Mini Nutritional Assessment (MNA)...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731551/sarcopenia-and-hospitalisation-costs-in-older-adults-a-cross-sectional-study
#3
Ana C Antunes, Daniela A Araújo, Manuel T Veríssimo, Teresa F Amaral
AIM: The impact of sarcopenia on hospitalisation has been under intense investigation; however, little is known about the association between sarcopenia and their costs among hospitalised patients. The aim of the present study was to quantify the association between sarcopenia and hospitalisation costs among older adults. METHODS: A cross-sectional study was conducted in 201 hospitalised older adults in a general hospital. Sarcopenia was identified according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28721433/oral-health-and-the-frail-elderly
#4
L Rapp, S Sourdet, B Vellas, M-H Lacoste-Ferré
INTRODUCTION: The relationships between oral health conditions and frailty have rarely been explored. A systematic review of frailty components and oral health concluded that differences in study population endpoint criteria and study design cannot establish a relationship between frailty and oral health. OBJECTIVE: This study aims to describe the distribution of the OHAT (Oral Health Assessment Tool) score in a population of frail subjects and to assess associated parameters (age, socio-economic status, living conditions, education level, nutritional habits, cognitive functioning, autonomy)...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28720493/crystal-structures-of-monkey-and-mouse-nicotinamide-n-methyltransferase-nnmt-bound-with-end-product-1-methyl-nicotinamide
#5
Srinivasan Swaminathan, Swarnakumari Birudukota, Manish Kumar Thakur, Reejuana Parveen, Saravanan Kandan, Suresh Juluri, Shama Shaik, Niranjan Naranapura Anand, Raghunadha Reddy Burri, Rajendra Kristam, Sridharan Rajagopal, Herman Schreuder, Thomas Langer, Christine Rudolph, Sven Ruf, Saravanakumar Dhakshinamoorthy, Ramachandraiah Gosu, Aimo Kannt
Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-L-methionine (SAM)-dependent enzyme that catalyzes N-methylation of nicotinamide (NA) and other pyridines to form N-methyl pyridinium ions. Here we report the first ternary complex X-ray crystal structures of monkey NNMT and mouse NNMT in bound form with the primary endogenous product, 1-methyl nicotinamide (MNA) and demethylated cofactor, S-adenosyl-homocysteine (SAH) determined at 2.30 Å and 1.88 Å respectively. The structural fold of these enzymes is identical to human NNMT...
July 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28699419/chair-rise-capacity-and-associated-factors-in-older-home-care-clients
#6
Miia Tiihonen, Sirpa Hartikainen, Irma Nykänen
AIMS: The aim of this study was to investigate the ability of older home-care clients to perform the five times chair rise test and associated personal characteristics, nutritional status and functioning. METHODS: The study sample included 267 home-care clients aged ≥75 years living in Eastern and Central Finland. The home-care clients were interviewed at home by home-care nurses, nutritionists and pharmacists. The collected data contained sociodemographic factors, functional ability (Barthel Index, IADL), cognitive functioning (MMSE), nutritional status (MNA), depressive symptoms (GDS-15), medical diagnoses and drug use...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28699010/chemical-characterization-of-size-segregated-pm-from-different-public-transport-modes-and-implications-of-source-specific-contribution-to-public-exposure
#7
Sabrina Yanan Jiang, Nirmal Kumar Gali, Fenhuan Yang, Junke Zhang, Zhi Ning
To investigate the chemical properties of particulate matter (PM) in different public transport microenvironments in Hong Kong, the coarse (2.5-10 μm) and fine (<2.5 μm) PM samples were collected in three different types of transport modes including Mass Transit Railway (MTR)-Aboveground (AG), MTR Underground (UG), and Bus routes from October 2013 to April 2014. Average PM2.5 concentrations through UG, AG, and Bus routes were 47.9, 86.8, and 43.8 μg m(-3), respectively, whereas the coarse PM concentrations were 4-5 folds less...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28696504/association-of-mycn-copy-number-with-clinical-features-tumor-biology-and-outcomes-in-neuroblastoma-a-report-from-the-children-s-oncology-group
#8
Kevin Campbell, Julie M Gastier-Foster, Meegan Mann, Arlene H Naranjo, Collin Van Ryn, Rochelle Bagatell, Katherine K Matthay, Wendy B London, Meredith S Irwin, Hiroyuki Shimada, M Meaghan Granger, Michael D Hogarty, Julie R Park, Steven G DuBois
BACKGROUND: High-level MYCN amplification (MNA) is associated with poor outcome and unfavorable clinical and biological features in patients with neuroblastoma. To the authors' knowledge, less is known regarding these associations in patients with low-level MYCN copy number increases. METHODS: In this retrospective study, the authors classified patients has having tumors with MYCN wild-type tumors, MYCN gain (2-4-fold increase in MYCN signal compared with the reference probe), or MNA (>4-fold increase)...
July 11, 2017: Cancer
https://www.readbyqxmd.com/read/28688052/carboplatin-plus-weekly-nanoparticle-albumin-bound-paclitaxel-in-elderly-patients-with-previously-untreated-advanced-squamous-non-small-cell-lung-cancer-selected-based-on-mini-nutritional-assessment-short-form-scores-a-multicenter-phase-2-study
#9
Takayuki Shiroyama, Motohiro Tamiya, Seigo Minami, So Takata, Kentaro Masuhiro, Yu Futami-Nishijima, Takeshi Uenami, Masahide Mori, Taro Koba, Takanori Matsuki, Takayuki Takimoto, Hidekazu Suzuki, Norio Okamoto, Kiyoshi Komuta, Tomonori Hirashima, Atsushi Kumanogoh, Takashi Kijima
PURPOSE: This multicenter, single-arm, open-label, phase 2 study assessed the efficacy and safety of carboplatin plus weekly nanoparticle albumin-bound paclitaxel in elderly patients with previously untreated advanced squamous non-small-cell lung cancer, selected based on the Mini Nutritional Assessment short-form scores (MNA-SF). METHODS: Patients received carboplatin (area under the curve: 6) on Day 1, and nanoparticle albumin-bound paclitaxel (100 mg/m(2)) on Days 1, 8, and 15, every 28 days for ≤4 cycles...
July 7, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28677423/usefulness-of-cytologic-criteria-in-ultrasound-guided-fine-needle-aspirates-from-subcentimeter-canine-mammary-tumors
#10
Alessio Pierini, Francesca Millanta, Roberta Zanforlin, Iacopo Vannozzi, Veronica Marchetti
We determined cytologic features of histologically confirmed subcentimeter canine mammary tumors (CMTs) to determine reasonable criteria for an accurate cytologic diagnosis. Fifty-three CMTs from 28 bitches were included. All cytologic samples were collected by ultrasound-guided fine-needle aspiration biopsy, stained with May-Grünwald/Giemsa, and retrospectively evaluated using a scoring system established for 18 cytologic features. Mean nuclear area (MNA) was also measured for each sample by a computer-assisted program...
July 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28673255/prevalence-of-malnutrition-and-associated-factors-among-hospitalized-elderly-patients-in-king-abdulaziz-university-hospital-jeddah-saudi-arabia
#11
Sami H Alzahrani, Sultan H Alamri
BACKGROUND: Malnutrition is a nutritional disorder that adversely affects the body from a functional or clinical perspective. It is very often observed in the elderly population. This study aimed to estimate the prevalence of malnutrition among hospitalized elderly patients and its associated factors and outcomes in terms of length of stay and mortality in King Abdulaziz University Hospital, Jeddah, Saudi Arabia. METHODS: In a cross-sectional study, we evaluated the nutritional status of hospitalized elderly patients using the most recent version of the short form of Mini Nutritional Assessment (MNA-SF)...
July 3, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28672199/changes-in-malnutrition-and-quality-of-nutritional-care-among-aged-residents-in-all-nursing-homes-and-assisted-living-facilities-in-helsinki-2003-2011
#12
Riitta K T Saarela, Seija Muurinen, Merja H Suominen, Niina N Savikko, Helena Soini, Kaisu H Pitkälä
BACKGROUND: While nutritional problems have been recognized as common in institutional settings for several decades, less is known about how nutritional care and nutrition has changed in these settings over time. OBJECTIVES: To describe and compare the nutritional problems and nutritional care of residents in all nursing homes (NH) in 2003 and 2011 and residents in all assisted living facilities (ALF) in 2007 and 2011, in Helsinki, Finland. METHODS: We combined four cross-sectional datasets of (1) residents from all NHs in 2003 (N=1987), (2) residents from all ALFs in 2007 (N=1377), (3) residents from all NHs in 2011 (N=1576) and (4) residents from all ALFs in 2011 (N=1585)...
September 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28671332/association-between-malnutrition-and-hyperhomocysteine-in-alzheimer-s-disease-patients-and-diet-intervention-of-betaine
#13
Jianying Sun, Shiling Wen, Jing Zhou, Shuling Ding
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease, which is associated with malnutrition and hyperhomocysteine. The current study aimed to analyze the relationship between malnutrition and hyperhomocysteine in AD patients, and effects of diet intervention with betaine on the disease. METHODS: The nutritional statuses of the AD patients were assessed by short form mini nutritional assessment (MNA-SF). The levels of Hcy, tau hyperphosphorylation, synaptic proteins, blood inflammatory factors were measured by enzymatic cycling assay, Western blot and ELISA...
November 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28656557/distribution-and-assessment-of-heavy-metal-toxicity-in-sediment-cores-from-bizerte-lagoon-tunisia
#14
Haïfa Ben Mna, Walid Oueslati, Mohamed Amine Helali, Noureddine Zaaboub, Ayed Added, Lotfi Aleya
To examine the state of pollution of Bizerte Lagoon which is exposed to intense anthropogenic pressure, two sediment cores were taken at two sites, one undergoes the dual effects of both marine waters arriving from the Mediterranean Sea through the Channel, and also of freshwater from the Tinja River; the other core is located at the center of the lagoon where water depth is maximal (12 m). Heavy metal concentrations in the two cores were assessed, with calculated enrichment factors and geo-accumulation indexes...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28647292/risk-factors-of-refeeding-syndrome-in-malnourished-older-hospitalized-patients
#15
Maryam Pourhassan, Ingeborg Cuvelier, Ilse Gehrke, Christian Marburger, Mirja Katrin Modreker, Dorothee Volkert, Hans-Peter Willschrei, Rainer Wirth
BACKGROUND & AIMS: Despite the high prevalence of malnutrition among older hospitalized persons, it is unknown how many of these malnourished patients are at risk of developing the refeeding syndrome (RFS). In this study, we sought to compare the prevalence and severity of malnutrition among older hospitalized patients with prevalence of known risk factors of RFS. METHODS: This cross-sectional multicenter-study investigated older participants who were consecutively admitted to the geriatric acute care ward...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28642623/predicting-long-term-mortality-in-hospitalized-elderly-patients-using-the-new-espen-definition
#16
Jiaojiao Jiang, Xiaoyi Hu, Jing Chen, Haozhong Wang, Lei Zhang, Birong Dong, Ming Yang
The European Society of Clinical Nutrition and Metabolism (ESPEN) recently published new diagnostic criteria for malnutrition. The aim of this study was to evaluate whether malnutrition by the new ESPEN diagnostic criteria can predict long-term mortality in elderly inpatients. We conducted a prospective study in the acute geriatric wards. Malnutrition was defined according to the new ESPEN criteria and the Mini Nutritional Assessment (MNA), respectively. The survival status was determined by telephone interviews at 3-years...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611344/plasma-ghrelin-and-leptin-in-patients-with-inflammatory-bowel-disease-and-its-association-with-nutritional-status
#17
Firas A Ghomraoui, Sami T Alotaibi, Meshal A Alharthi, Saeed S Asiri, Majid A Almadi, Othman R Alharbi, Nahla A Azzam, Abdulrahman M Aljebreen, Maria Saeed, Baraa Hajkhder, Waleed Saeed, Mohammad A Alzoghaibi
BACKGROUND/AIMS: Ghrelin and leptin are thought to play a role in the loss of appetite in active inflammatory bowel disease (IBD). This study seeks to probe into the association of these markers with regards to IBD and the nutritional status of these patients. A case-control study was conducted between May 2015 and March 2016 at King Khalid University Hospital (KKUH). Thirty-one patients with IBD (both active and non-active) and forty-one healthy controls (both non-fasting and fasting) were recruited...
May 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28600505/malnutrition-sarcopenia-syndrome-predicts-mortality-in-hospitalized-older-patients
#18
Xiaoyi Hu, Lei Zhang, Haozhong Wang, Qiukui Hao, Birong Dong, Ming Yang
A new term, malnutrition-sarcopenia syndrome (MSS), was recently coined to describe the clinical presentation of both malnutrition and sarcopenia. The aim of this study was to investigate the association between MSS and long-term mortality in older inpatients. We conducted a prospective study in acute geriatric wards of two local hospitals in China. Muscle mass and malnutrition were estimated by anthropometric measures and the Mini Nutritional Assessment (MNA). Of the 453 participants, 14 (3.1%) had sarcopenia with normal nutrition, 139 (30...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28595900/-study-of-the-nutritional-status-of-patients-over-65-years-included-in-the-home-care-program-in-an-urban-population
#19
Belén Muñoz Díaz, Antonio P Arenas de Larriva, Guillermo Molina-Recio, Rafael Moreno-Rojas, Jorge Martínez de la Iglesia
OBJECTIVE: To analyse the nutritional status of patients older than 65 years included in the home care program (PAD). DESIGN: Croos-sectional study. EMPLACEMENT: 3 urban health centers. PARTICIPANTS: 218 patients in the PAD. METHOD: Mini Nutritional Assessment questionnaire (MNA) was applied. Sociodemographic, anthropometric, dependency, emotional and cognitive status and analytical parameters: 57 variables were collected...
June 5, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28592356/use-of-health-resources-and-healthcare-costs-associated-with-nutritional-risk-the-fradea-study
#20
Marta Martínez-Reig, Isaac Aranda-Reneo, Luz M Peña-Longobardo, Juan Oliva-Moreno, Núria Barcons-Vilardell, Emiel O Hoogendijk, Pedro Abizanda
BACKGROUND: In spite of its high prevalence and its clinical relevance, the economic impact of malnutrition has not been sufficiently explored. OBJECTIVE: To study whether malnutrition predicts total hospital healthcare costs and costs related to specialist visits, emergency department visits and hospitalization in older adults. METHODS: Concurrent cohort study in Albacete City, Spain. The study sample included 827 subjects aged 70 and over from the FRADEA Study...
May 27, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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