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https://www.readbyqxmd.com/read/28408051/beyond-body-mass-index-is-the-body-cell-mass-index-bcmi-a-useful-prognostic-factor-to-describe-nutritional-inflammation-and-muscle-mass-status-in-hospitalized-elderly-body-cell-mass-index-links-in-elderly
#1
Mariangela Rondanelli, Jacopo Talluri, Gabriella Peroni, Chiara Donelli, Fabio Guerriero, Krizia Ferrini, Emilia Riggi, Elisabetta Sauta, Simone Perna, Davide Guido
BACKGROUND & AIM: The aim of this study was to establish the effectiveness of Body Cell Mass Index (BCMI) as a prognostic index of (mal)nutrition, inflammation and muscle mass status in the elderly. METHODS: A cross-sectional observational study has been conducted on 114 elderly patients (80 women and 34 men), with mean age equal to 81.07 ± 6.18 years. We performed a multivariate regression model by Structural Equation Modelling (SEM) framework. We detected the effects over a Mini Nutritional Assessment (MNA) stratification, by performing a multi-group multivariate regression model (via SEM) in two MNA nutritional strata, less and bigger (or equal) than 17...
March 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28392164/relationship-of-nutritional-status-and-oral-health-in-elderly-systematic-review-with-meta-analysis
#2
Mirian Paola Toniazzo, Paula de Sant'Ana Amorim, Francisco Wilker Mustafa Gomes Muniz, Patricia Weidlich
This systematic review aimed to compare the nutritional status and oral health in older adults individuals. Three databases (Medline-Pubmed, Scopus and EMBASE) were searched up to October 28th 2016 for studies that performed the Subjective Global Assessment (SGA) or the Mini Nutritional Assessment (MNA) and an oral examination performed by a dental professional, either dental hygienist or a dentist. Both observational and interventional studies were screened for eligibility. Meta-analyses were performed comparing the malnourished/at risk of malnutrition and the normal nutrition subjects with three oral health parameters (edentulism, use of prosthesis and mean number of present teeth)...
March 28, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28390901/bcg-vaccine-powder-laden-and-dissolvable-microneedle-arrays-for-lesion-free-vaccination
#3
Fan Chen, Qinying Yan, Yang Yu, Mei X Wu
Live attenuated Bacille Calmette-Guerin (BCG) bacillus is the only licensed vaccine for tuberculosis prevention worldwide to date. It must be delivered intradermally to be effective, which causes severe skin inflammation and sometimes, permanent scars. To minimize the side effects, we developed a novel microneedle array (MNA) that could deliver live attenuated freeze-dried BCG powder into the epidermis in a painless, lesion-free, and self-applicable fashion. The MNA was fabricated with biocompatible and dissolvable hyaluronic acid with a deep cave formed in the basal portion of each microneedle, into which BCG powder could be packaged directly...
April 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28382608/malnutrition-and-quality-of-life-in-patients-with-non-small-cell-lung-cancer
#4
Jacek Polański, Beata Jankowska-Polańska, Izabella Uchmanowicz, Mariusz Chabowski, Dariusz Janczak, Grzegorz Mazur, Joanna Rosińczuk
Progressive weight loss, common reduces performance and quality of life in patients with advanced lung cancer. However, there is a paucity of studies that focus on nutritional status and quality of life of non-small cell lung cancer (NSCLC) patients. The present study seeks to determine the nutritional status, and its relation to quality of life, of NSCLC patients. One hundred and eighty NSCLC patients (mean age 62.8 ± 9.6 years) were evaluated during therapy at the Lower Silesian Center of Lung Diseases in Wroclaw, Poland...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28359364/age-dependent-risk-factors-for-malnutrition-in-traumatology-and%C3%A2-orthopedic-patients
#5
Christine Lambert, Andreas Nüssler, Hans Konrad Biesalski, Thomas Freude, Christian Bahrs, Gunnar Ochs, Ingo Flesch, Ulrich Stöckle, Christoph Ihle
OBJECTIVE: The aim of this study was to investigate the prevalence of risk of malnutrition (RoM) in an orthopedic and traumatology patient cohort with a broad range of ages. In addition to the classical indicators for risk assessment (low body mass index, weight loss, and comorbidity), this study aimed to analyze the effects of lifestyle factors (eating pattern, smoking, physical activity) on RoM. METHODS: The prospective cohort study included 1053 patients in a level 1 trauma center in Germany...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28346570/tolerance-and-long-term-efficacy-of-polyethylene-glycol-4000-forlax%C3%A2-compared-to-lactulose-in-elderly-patients-with-chronic-constipation
#6
P Chassagne, P Ducrotte, P Garnier, H Mathiex-Fortunet
OBJECTIVES: To assess the tolerance and potential nutritional consequences of long-term repeated doses of PEG 4000 (10 to 30 g/day) in elderly patients with chronic constipation as compared to lactulose (10-30 g/day). DESIGN: Single blind, randomised, multicentre, parallel group comparative study. SETTING: Community-dwelling patients and nursing homes residents aged 70 years and older with a history of chronic constipation. Treatment intervention: PEG 4000 (10-30 g/day) or lactulose (10-30 g/day) for six months...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28345773/screening-for-malnutrition-in-hospitalised-older-people-comparison-of-the-mini-nutritional-assessment-with-its-short-form-versions
#7
Elsa Dent, Ian Chapman, Cynthia Piantadosi, Renuka Visvanathan
OBJECTIVE: To determine how well the Mini Nutritional Assessment (MNA) Short Form (MNA-SF) performed as a nutritional screening tool when calf circumference replaced body mass index (BMI) as the included anthropometric measurement. METHODS: A total of 100 patients ≥70 years were recruited from a Geriatric Evaluation and Management Unit. RESULTS: Mean age of patients was 85.2 (6.1) years. By the full MNA, 40% of patients were malnourished...
March 27, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28320137/what-increases-the-risk-of-malnutrition-in-parkinson-s-disease
#8
Svetlana Tomic, Vlasta Pekic, Zeljka Popijac, Tomislav Pucic, Marta Petek, Tihana Gilman Kuric, Sanja Misevic, Ruzica Palic Kramaric
Parkinson's disease (PD) patients are at a higher risk of malnutrition. The prevalence has been estimated to 0-24%, while 3%-60% of PD patients are reported to be at risk of malnutrition. To date, there is no clear explanation for malnutrition in these patients. The aim of this study was to determine the prevalence of malnutrition and to analyze factors that influence its appearance. The Mini Nutritional Assessment (MNA) was used to determine normal nutritional status; at risk of malnutrition; and already malnourished status...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28314293/assessment-of-nutritional-and-inflammatory-status-to-determine-the-prevalence-of-malnutrition-in-patients-undergoing-surgery-for-colorectal-carcinoma
#9
Antonella Daniele, Rosa Divella, Ines Abbate, Addolorata Casamassima, Vito Michele Garrisi, Eufemia Savino, Porzia Casamassima, Eustachio Ruggieri, Raffaele DE Luca
BACKGROUND/AIM: Colorectal Cancer is the fourth most frequent cause of cancer death worldwide and its incidence increases from 50 years of age. It is often associated with protein-caloric malnutrition and 20% of cancer deaths occur due to this event. The aim of this study was to assess the prevalence of malnutrition and inflammatory status in 78 patients undergoing surgery for colorectal carcinoma. PATIENTS AND METHODS: Nutritional Status was assessed by Mini Nutritional Assessment (MNA)...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28283859/combination-of-sedds-and-preactivated-thiomer-technology-incorporation-of-a-preactivated-thiolated-amphiphilic-polymer-into-self-emulsifying-delivery-systems
#10
Gergely Hetényi, Janine Griesser, Isabelle Nardin, Andreas Bernkop-Schnürch
PURPOSE: The aim of the study was to create novel mucoadhesive drug delivery systems by incorporating amphiphilic hydrophobically modified, thiolated and preactivated polymers (preactivated thiomers) into self-emulsifying drug delivery systems (SEDDS). METHODS: L-Cysteine methyl ester was covalently attached to the polymeric backbone of Pemulen TR-2 and preactivated using 2-mercaptonicotinic acid (2-MNA). These thiomers were incorporated in a concentration of 0...
March 10, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28276543/large-scale-qm-mm-calculations-of-the-camn4o5-cluster-in-the-s3-state-of-the-oxygen-evolving-complex-of-photosystem-ii-comparison-between-water-inserted-and-no-water-inserted-structures
#11
Mitsuo Shoji, Hiroshi Isobe, Takahito Nakajima, Yasuteru Shigeta, Michihiro Suga, Fusamichi Akita, Jian-Ren Shen, Kizashi Yamaguchi
Large-scale QM/MM calculations were performed to elucidate an optimized geometrical structure of a CaMn4O5 cluster with and without water insertion in the S3 state of the oxygen evolving complex (OEC) of photosystem II (PSII). The left (L)-opened structure was found to be stable under the assumption of no hydroxide anion insertion in the S3 state, whereas the right (R)-opened structure became more stable if one water molecule is inserted to the Mn4Ca cluster. The optimized Mna(4)-Mnd(1) distance determined by QM/MM was about 5...
March 9, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28270133/the-effects-of-1-4-dimethylpyridine-in-metastatic-prostate-cancer-in-mice
#12
Agnieszka Denslow, Marta Switalska, Marcin Nowak, Magdalena Maciejewska, Stefan Chlopicki, Andrzej Marcinek, Jerzy Gebicki, Joanna Wietrzyk
BACKGROUND: We previously showed that 1-methylnicotinamide (1-MNA) and its analog 1,4-dimethylpyridine (1,4-DMP) could inhibit the formation of lung metastases and enhance the efficacy of cyclophosphamide-based chemotherapy in the model of spontaneously metastasizing 4T1 mouse mammary gland tumors. In the present study, we aimed to investigate whether the previously observed activity of pyridine compounds pertains also to the prevention and the treatment of metastatic prostate tumors, in a combined chemotherapy with docetaxel...
March 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28263371/association-between-preoperative-malnutrition-and-postoperative-delirium-after-hip-fracture-surgery-in-older-adults
#13
Paolo Mazzola, Libby Ward, Sara Zazzetta, Valentina Broggini, Alessandra Anzuini, Breanna Valcarcel, Justin S Brathwaite, Giulio M Pasinetti, Giuseppe Bellelli, Giorgio Annoni
OBJECTIVES: To determine whether poor nutritional status can predict postoperative delirium in elderly adults undergoing hip fracture surgery. DESIGN: Prospective observational cohort study. SETTING: Italian orthogeriatric unit. PARTICIPANTS: Individuals aged 70 and older (mean age 84.0 ± 6.6, 74.5% female) consecutively admitted for surgical repair of a proximal femur fracture between September 2012 and April 2016 (N = 415)...
March 6, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28249678/comparison-of-the-mini-nutritional-assessment-short-and-long-form-and-serum-albumin-as-prognostic-indicators-of-hip-fracture-outcomes
#14
Heli Helminen, Tiina Luukkaala, Juha Saarnio, Maria Nuotio
INTRODUCTION: Malnutrition is common among older hip fracture patients and associated with adverse outcomes. We examined Mini Nutritional Assessment short (MNA-SF) and long form (MNA-LF) and serum albumin as prognostic indicators of mobility, living arrangements and mortality after hip fracture. METHODS: Population-based prospective data were collected on 594 hip fracture patients aged 65 and over. MNA-SF, MNA-LF and serum albumin were assessed on admission. Outcomes were poorer mobility; transfer to more assisted living accommodation and mortality one month, four months and one year post fracture...
February 22, 2017: Injury
https://www.readbyqxmd.com/read/28214764/recurrent-falls-and-its-risk-factors-among-older-men-living-in-the-veterans-retirement-communities-a-cross-sectional-study
#15
Cheng-Hao Hung, Chih-Jen Wang, Ting-Ching Tang, Liang-Yu Chen, Li-Ning Peng, Fei-Yuan Hsiao, Liang-Kung Chen
AIM: To evaluate the prevalence of recurrent falls and their risk factors among older men living in the Veterans Homes in Taiwan. METHODS: This cross-sectional study enrolled 871 residents and all participants received the comprehensive geriatric assessment, including Barthel Index, Mini-Mental Status Examination (MMSE), Geriatric Depression Scale-5 questions (GDS-5), Mini-Nutrition Assessment Short Form (MNA-SF), the status of urinary incontinence, stool incontinence, polypharmacy, past history of falls, multimorbidity, and medication history...
May 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28214402/relationship-between-chewing-ability-and-cognitive-impairment-in-the-rural-elderly
#16
Eun-Kyong Kim, Sung Kook Lee, Youn-Hee Choi, Makiko Tanaka, Kimiko Hirotsu, Hyeon Chang Kim, Hee-Kyung Lee, Yun-Sook Jung, Atsuo Amano
OBJECTIVE: Relationship between masticatory function and cognitive impairment had been suggested but still understudied. We investigated the association between chewing ability and cognitive impairment among the elderly living in a rural region. METHODS: A total of 295 elderly individuals aged ≥70 years in a rural city of Korea participated in a cross-sectional study. Trained nurses conducted interviews and assessed chewing ability using gum that changed color based on chewing performance...
May 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28196115/nutritional-assessment-of-community-dwelling-older-adults-in-rural-nepal
#17
Saruna Ghimire, Binaya Kumar Baral, Karen Callahan
BACKGROUND: Demographic transition in Nepal, like in many developing countries, has resulted in a burgeoning elderly population whose health status is not currently monitored. One pillar of health is adequate nutrition. Yet, little is known about the nutritional health status of the elderly in Nepal. The financial, material, and personnel limitations in Nepal's health delivery services necessitate health screening instruments that require minimal clinical staff and resources. To our knowledge, no such nutritional assessment tool has been validated in Nepal...
2017: PloS One
https://www.readbyqxmd.com/read/28187148/nutritional-status-and-body-composition-by-bioelectrical-impedance-vector-analysis-a-cross-sectional-study-in-mild-cognitive-impairment-and-alzheimer-s-disease
#18
Ilaria Cova, Simone Pomati, Laura Maggiore, Marica Forcella, Valentina Cucumo, Roberta Ghiretti, Giulia Grande, Fulvio Muzio, Claudio Mariani
AIMS: Analysis of nutritional status and body composition in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). METHODS: A cross-sectional study was performed in a University-Hospital setting, recruiting 59 patients with AD, 34 subjects with MCI and 58 elderly healthy controls (HC). Nutritional status was assessed by anthropometric parameters (body mass index; calf, upper arm and waist circumferences), Mini Nutritional Assessment (MNA) and body composition by bioelectrical impedance vector analysis (BIVA)...
2017: PloS One
https://www.readbyqxmd.com/read/28174491/comprehensive-evaluation-of-nutritional-status-before-and-after-hematopoietic-stem-cell-transplantation-in-170-patients-with-hematological-diseases
#19
Peng Liu, Boshi Wang, Xia Yan, Jingjing Cai, Yu Wang
OBJECTIVE: To investigate the nutritional status of patients before and after hematopoietic stem cell transplantation (HSCT), and explore optimal methods for assessing nutritional status in patients with hematological diseases. METHODS: This cohort study enrolled 170 patients who were diagnosed with hematological diseases and underwent allogeneic HSCT in the Department of Hematology, Peking University People's Hospital between May 2011 and April 2013. We used fixed-point continuous sampling and four nutritional screening tools, Nutritional Risk Screening 2002 (NRS-2002), Mini Nutritional Assessment (MNA), Subjective Global Assessment (SGA) and Malnutrition Universal Screening Tools (MUST), in combination with body measurements, to extensively screen and evaluate nutritional risks and status in patients receiving HSCT before entering and after leaving laminar air flow rooms...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28153597/pharmacokinetic-profile-of-1-methylnicotinamide-nitrate-in-rats
#20
Malgorzata Szafarz, Kamil Kus, Maria Walczak, Agnieszka Zakrzewska, Michal Niemczak, Juliusz Pernak, Stefan Chlopicki
Treatment with 1-methylnicotinamide (MNA), a major metabolite of nicotinamide, exerts antithrombotic, anti-inflammatory, and vasoprotective effects. Yet, pharmacokinetic (PK) profile of MNA has not been fully characterized. In the present work, we analyze the PK profile of the MNA given as a nitrate (MNANO3) in comparison to nitrite (MNANO2) or chloride (MNACl) in rats. The bioavailability of MNA administered as MNANO3 equaled 22.4% as compared to MNANO2 or MNACl (9.2% and 9.1%, respectively). Moreover, in single-pass intestinal perfusion experiments, effective permeability of MNA given as MNANO3 was higher as compared to MNA administered as MNANO2 or MNACl...
January 30, 2017: Journal of Pharmaceutical Sciences
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