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Şule Özbilgin, Volkan Hanc, Dilek Ömür, Mücahit Özbilgin, Mine Tosun, Serhan Yurtlu, Semih Küçükgüçlü, Atalay Arkan
The aim was to evaluate the nutritional situation of patients admitted to the Postoperative Acute Care Unit using classic methods of objective anthropometry, systemic evaluation methods, and Nutrition Risk in Critically Ill (NUTRIC) score, and to compare them as a predictor of morbidity and mortality.At admission to the postoperative care unit, patients undergoing various surgeries were assessed for the following items: Subjective Global Assessment (SGA), Nutritional Risk Index (NRI), Nutritional Risk Screening (NRS)-2002, Mini Nutritional Assessment (MNA), Charlson comorbidity index (CCI), and NUTRIC score, anthropometric measurements, serum total protein, serum albumin, and lymphocyte count...
October 2016: Medicine (Baltimore)
Iva Brabcová, Marie Trešlová, Sylva Bártlová, Jitka Vacková, Valerie Tóthová, Lenka Maťhová
BACKGROUND AND AIM: Nutrition is an important social determinant of health that influences the ageing process. The aim of this study was to evaluate the nutritional condition of a group of seniors and identify the bio-psycho-social factors that increase the risk of malnutrition. METHODS: The research was conducted using a quantitative method. The standardised scales Mini Nutritional Assessment - Short Form (MNA-SF) and the Geriatric depression scale (GDS-5) were used to evaluate the nutritional condition and tendency towards depression of the tested group...
September 2016: Central European Journal of Public Health
Renxin Wang, Wei Wang, Zhihong Li
Silicon microneedle arrays (MNAs) have been widely studied due to their potential in various transdermal applications. However, discrete MNAs, as a preferred choice to fabricate flexible penetrating devices that could adapt curved and elastic tissue, are rarely reported. Furthermore, the reported discrete MNAs have disadvantages lying in uniformity and height-pitch ratio. Therefore, an improved technique is developed to manufacture discrete MNA with tunable height-pitch ratio, which involves KOH-dicing-KOH process...
October 9, 2016: Sensors
Eun Kim, Geza Erdos, Shaohua Huang, Thomas Kenniston, Louis D Falo, Andrea Gambotto
Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA)...
October 3, 2016: EBioMedicine
Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co-administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t and AUC0-∞ of 6-MNA after co-administration with pure AN and APE has been observed. Tmax of 6-MNA has been increased to 2 h from 1.5 h in AN + NAB treated group...
October 7, 2016: Phytotherapy Research: PTR
Sami Hamdan Alzahrani, Ismail Abdelmoneim El Sayed, Sarah Mohammed Alshamrani
BACKGROUND: Malnutrition is highly prevalent among the elderly and is associated with poor clinical prognosis, decreased functional status, and increased morbidity and mortality. OBJECTIVE: To estimate the prevalence of geriatric malnutrition among outpatients of a geriatric clinic and to determine factors associated with malnutrition. DESIGN: Cross-sectional study. SETTING: Geriatric outpatient clinic of the King Abdul Aziz University Hospital, Jeddah...
September 2016: Annals of Saudi Medicine
V Soler, S Sourdet, L Balardy, G Abellan van Kan, D Brechemier, M E Rougé-Bugat, N Tavassoli, M Cassagne, F Malecaze, F Nourhashémi, B Vellas
OBJECTIVES: To evaluate visual performance and factors associated with abnormal vision in patients screened for frailty at the Geriatric Frailty Clinic (GFC) for Assessment of Frailty and Prevention of Disability at Toulouse University Hospital. DESIGN: Retrospective, observational cross-sectional, single-centre study. SETTING: Institutional practice. PARTICIPANTS: Patients were screened for frailty during a single-day hospital stay between October 2011 and October 2014 (n = 1648)...
2016: Journal of Nutrition, Health & Aging
J L Pedersen, P U Pedersen, E M Damsgaard
OBJECTIVES: To compare the effects of two nutritional follow-up interventions with regard to preventing short-term deterioration in ADL, and to compare their effects on physical function, emotional health, and health-related quality of life. DESIGN: Randomized clinical trial with two intervention groups and one control group, and a follow-up period of eight weeks. SETTING: Intervention in the participants' homes after discharge from hospital...
2016: Journal of Nutrition, Health & Aging
L Lera, H Sánchez, B Ángel, C Albala
OBJECTIVES: To validate the short-form of the MNA (MNA-SF) and the cut-off point of 31 cm for calf circumference (CC) in older people in Latin America. METHODS: A cross-sectional study was conducted with 5,722 community-dwelling older subjects (range: 60-102 years) in Latin America´s five main cities: Sao Paulo (Brazil), Santiago (Chile), Havana (Cuba), Mexico DF (Mexico) and Montevideo (Uruguay). All participants underwent an interview, which included anthropometric measurements, completing the MNA and obtaining socio-demographic, nutrition and health information...
2016: Journal of Nutrition, Health & Aging
Felix Prüfert, Sonja Bonengel, Claudia Menzel, Andreas Bernkop-Schnürch
The objective of this study was to develop a novel thiomer with enhanced mucoadhesive properties using a highly mucoadhesive polymeric backbone. Fixomer™ A-30 (poly(methacrylic acid-co-sodium acrylamidomethyl propane sulfonate)), exhibiting a mucoadhesive strength superior to that of all other polymers, was thiolated by conjugation with l-cysteine and furthermore preactivated with 2-mercaptonicotinic acid (MNA). The resulting derivatives Fix-SH and Fix-S-MNA exhibited coupling rates of 755μmol thiol groups and 304μmol MNA per gram polymer, respectively...
October 1, 2016: European Journal of Pharmaceutical Sciences
Nermine O Basta, Gail C Halliday, Guy Makin, Jillian Birch, Richard Feltbower, Nick Bown, Martin Elliott, Lucas Moreno, Giuseppe Barone, Andrew Dj Pearson, Peter W James, Deborah A Tweddle, Richard Jq McNally
BACKGROUND: Despite therapeutic advances, survival following relapse for neuroblastoma patients remains poor. We investigated clinical and biological factors associated with length of progression-free and overall survival following relapse in UK neuroblastoma patients. METHODS: All cases of relapsed neuroblastoma, diagnosed during 1990-2010, were identified from four Paediatric Oncology principal treatment centres. Kaplan-Meier and Cox regression analyses were used to calculate post-relapse overall survival (PROS), post-relapse progression-free survival (PRPFS) between relapse and further progression, and to investigate influencing factors...
October 4, 2016: British Journal of Cancer
Kotomi Sakai, Enri Nakayama, Haruka Tohara, Tomomi Maeda, Motonobu Sugimoto, Takahiro Takehisa, Yozo Takehisa, Koichiro Ueda
The aim of this cross-sectional study was to investigate whether tongue strength observed in older adult inpatients of a rehabilitation hospital is associated with muscle function, nutritional status, and dysphagia. A total of 174 older adult inpatients aged 65 years and older in rehabilitation (64 men, 110 women; median age, 84 years; interquartile range, 80-89 years) who were suspected of having reduced tongue strength due to sarcopenia were included in this study. Isometric tongue strength was measured using a device fitted with a disposable oral balloon probe...
September 29, 2016: Dysphagia
C Ihle, C Bahrs, T Freude, M Bickel, I Spielhaupter, E Wintermeyer, L Stollhof, L Grünwald, P Ziegler, S Pscherer, U Stöckle, A Nussler
Background: The prevalence of malnutrition in hospitalised patients is reported to be between 16 and 55 % across disciplines. Within hospital care, screening for malnutrition is required. However, in orthopaedics and trauma surgery, there is still no generally accepted recommendation for the methods for such a data survey. In the present study, the following aspects are to be investigated with the help of two established scores: (1) the prevalence of malnutrition in the patient population of geriatric trauma care, and (2) the correlation between methods of data survey...
September 29, 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
D Eschbach, T Kirchbichler, T Wiesmann, L Oberkircher, C Bliemel, S Ruchholtz, B Buecking
BACKGROUND: Most studies focusing on improving the nutritional status of geriatric trauma patients exclude patients with cognitive impairment. These patients are especially at risk of malnutrition at admission and of worsening during the perioperative fasting period. This study was planned as a feasibility study to identify the difficulties involved in including this high-risk collective of cognitively impaired geriatric trauma patients. PATIENTS AND METHODS: This prospective intervention study included cognitively impaired geriatric patients (Mini-Mental State Examination <25, age >65 years) with hip-related fractures...
2016: Clinical Interventions in Aging
Chih-Jen Wang, Cheng-Hao Hung, Ting-Ching Tang, Liang-Yu Chen, Li-Ning Peng, Fei-Yuan Hsiao, Liang-Kung Chen
AIMS: To evaluate the prevalence of urinary incontinence (UI) and its association with frailty among men aged 80 years and older in Taiwan METHODS: Residents living in four veterans retirement communities were invited for study and 440 men aged 80 years and older weer enrolled. Comprehensive geriatric assessment was performed for them, including using the following measurements: Clinical Frailty Scale, Northern Health and Social Care Trust (HSC)-Continence Assessment Form, Charlson's Comorbidity Index (CCI), Barthel Index (BI), Instrumental Activities of Daily Living (IADL), Mini-Mental State Examination (MMSE), Geriatric Depression Scale-5 (GDS-5), Mini-Nutritional Assessment-Short Form (MNA-SF)...
September 21, 2016: Rejuvenation Research
Dolores Sánchez-Rodríguez, Ester Marco, Natalia Ronquillo-Moreno, Ramón Miralles, Olga Vázquez-Ibar, Ferran Escalada, Josep M Muniesa
BACKGROUNDS & AIMS: The European Society of Clinical Nutrition and Metabolism (ESPEN) consensus definition of malnutrition has been applied in hospitalized older diabetics and middle-aged patients, geriatric outpatients, and healthy elderly and young individuals. In a post-acute care setting, our aim was to assess malnutrition (ESPEN definition) and determine its relationship with sarcopenia in older in-patients deconditioned due to an acute process. METHODS: Eighty-eight in-patients aged ≥70 years with body mass index (BMI) <30 kg/m(2) were included (84...
September 9, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Mario Tombini, Maura Sicari, Giovanni Pellegrino, Francesca Ursini, Pasqualina Insardá, Vincenzo Di Lazzaro
BACKGROUND: Malnutrition is one of the most important conditions that negatively affects the health of elder people, particularly in patients with dementia. OBJECTIVE: To provide an assessment of nutritional status of patients affected by Alzheimer's disease (AD) living at home and of their caregivers by means of Mini Nutritional Assessment (MNA), and to explore the influence of different factors on nutrition. METHODS: 90 patients affected by AD living at home and 90 age- and sex-matched caregivers were enrolled...
September 12, 2016: Journal of Alzheimer's Disease: JAD
Tatsuro Inoue, Syogo Misu, Toshiaki Tanaka, Hiroki Sakamoto, Kentaro Iwata, Yuki Chuman, Rei Ono
BACKGROUND & AIMS: Malnutrition is common in patients with hip fractures, and elderly patients with hip fractures lose functional independence and often fail to recover previous functional status. The aim of this study was to determine whether pre-fracture nutritional status predicts functional status of patients with hip fracture at discharge from acute hospitals. METHODS: In the present multicenter prospective cohort study, pre-fracture nutritional status was assessed using the Mini Nutritional Assessment Short-Form (MNA-SF)...
August 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Ivan Tanasić, Tijana Radaković, Ljiljana Tihaček Šojić, Aleksandra Milić Lemić, Ivan Soldatović
PURPOSE: The aim of this study was to find the correlation between the number, type, and placement of symmetric functional tooth units and the nutritional status using body mass index (BMI) and Mini Nutritional Assessment (MNA) in patients with both maxillary and mandibular removable partial dentures. MATERIALS AND METHODS: A randomized study was conducted at the Clinic for Prosthodontics, School of Dentistry, University of Belgrade, Serbia, followed by determination of number of functional tooth units...
September 2016: International Journal of Prosthodontics
Ellisiv Lærum Jacobsen, Therese Brovold, Astrid Bergland, Asta Bye
OBJECTIVES: Data on acute geriatric patients' nutritional status are lacking, and the associations among physical function, sarcopenia, health status and nutritional status are not sufficiently investigated in this population. The aims of this study are to investigate (1) nutritional status and sarcopenia in a group of acute geriatric patients, (2) the association between nutritional status, physical function and sarcopenia in acute geriatric patients, controlling for health status. DESIGN: A cross-sectional study...
2016: BMJ Open
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