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https://www.readbyqxmd.com/read/27914325/fabrication-of-metronidazole-loaded-poly-%C3%AE%C2%B5-caprolactone-zein-core-shell-nanofiber-membranes-via-coaxial-electrospinning-for-guided-tissue-regeneration
#1
Min He, Huiyi Jiang, Rui Wang, Yi Xie, Changsheng Zhao
To develop a biologically mimetic guided tissue regeneration (GTR) membrane with localized sustained drug release function to prevent infection, coaxial electrospinning technique was conducted to fabricate metronidazole (MNA)-loaded poly (ε-caprolactone) (PCL)/zein core/shell nanofibers. The nanofibers displayed a uniform bead-free round morphology as observed by scanning electron microscopy (SEM), and a core/shell structure as confirmed by transmission electron microscopy (TEM). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) characterizations demonstrated that the MNA was well dispersed in the nanofibers matrix...
November 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27893697/morbidity-and-mortality-predictivity-of-nutritional-assessment-tools-in-the-postoperative-care-unit
#2
Şule Özbilgin, Volkan Hanc, Dilek Ömür, Mücahit Özbilgin, Mine Tosun, Serhan Yurtlu, Semih Küçükgüçlü, Atalay Arkan
The aim was to evaluate the nutritional situation of patients admitted to the Postoperative Acute Care Unit using classic methods of objective anthropometry, systemic evaluation methods, and Nutrition Risk in Critically Ill (NUTRIC) score, and to compare them as a predictor of morbidity and mortality.At admission to the postoperative care unit, patients undergoing various surgeries were assessed for the following items: Subjective Global Assessment (SGA), Nutritional Risk Index (NRI), Nutritional Risk Screening (NRS)-2002, Mini Nutritional Assessment (MNA), Charlson comorbidity index (CCI), and NUTRIC score, anthropometric measurements, serum total protein, serum albumin, and lymphocyte count...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890621/nasal-drug-delivery-design-of-a-novel-mucoadhesive-and-in-situ-gelling-polymer
#3
Claudia Menzel, Max Jelkmann, Flavia Laffleur, Andreas Bernkop-Schnürch
The aim of the present study was to establish a novel polymeric excipient for liquid nasal dosage forms exhibiting viscosity increasing properties, improved mucoadhesion and stability towards oxidation in solution. In order to achieve this goal, 2-mercaptonicotinic acid was first coupled to L-cysteine by disulfide exchange reaction and after purification directly attached to the polymeric backbone of xanthan gum by carbodiimide mediated amide bond formation. The resulting conjugate was characterized with respect to the amount of coupled ligand, the in situ gelling behavior, mucoadhesive properties and stability towards oxidation...
November 24, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27887891/high-intake-of-nonmilk-extrinsic-sugars-is-associated-with-protein-and-micronutrient-dilution-in-home-dwelling-and-institutionalized-older-people
#4
Satu K Jyväkorpi, Kaisu H Pitkälä, Taija M Puranen, Mikko P Björkman, Hannu Kautiainen, Timo E Strandberg, Helena Soini, Merja H Suominen
BACKGROUND: High dietary sugar intake may compromise protein and micronutrient intakes in people with low energy intakes. The results of micronutrient dilution studies in older people have been few and conflicting. We examined the nutritional status and nutrient intakes associated with nonmilk extrinsic sugars (NMES) intakes in older people representing a broad spectrum of both healthy and vulnerable older populations. DESIGN AND PARTICIPANTS: This cross-sectional study combined five Finnish data sets covering home-dwelling (n = 526) and institutionalized (n = 374) older people...
November 22, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27883167/frailty-is-a-geriatric-syndrome-characterized-by-multiple-impairments-a-comprehensive-approach-is-needed
#5
L-K Chen, A-C Hwang, L-K Liu, W-J Lee, L-N Peng
OBJECTIVE: To evaluate the prevalence of frailty and the associated multimorbidity and functional impairments among community-dwelling middle-aged and elderly people in Taiwan. DESIGN: a cross-sectional study. SETTING: communities in I-Lan County of Taiwan. PARTICIPANTS: 1839 community-dwelling people aged 50 years and older. INTERVENTION: None. MEASUREMENTS: Frailty defined by Fried's criteria, Charlson's comorbidity index (CCI), Functional Autonomy Measurement System (SMAF), Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Nutrition Assessment (MNA), Mini-Mental State Examination (MMSE), and Short Form-12 quality of life questionnaire...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27879669/synthesis-of-a-morpholino-nucleic-acid-mna-uridine-phosphoramidite-and-exon-skipping-using-mna-2-o-methyl-mixmer-antisense-oligonucleotide
#6
Suxiang Chen, Bao T Le, Kamal Rahimizadeh, Khalil Shaikh, Narinder Mohal, Rakesh N Veedu
In this study, we synthesised a morpholino nucleoside-uridine (MNA-U) phosphoramidite and evaluated the potential of a MNA-modified antisense oligonucleotide (AO) sequences to induce exon 23 skipping in mdx mouse myotubes in vitro towards extending the applicability of morpholino chemistry with other nucleotide monomers. We designed, synthesised, and compared exon skipping efficiencies of 20 mer MNA-modified 2'-O-methyl RNA mixmer AO on a phosphorothioate backbone (MNA/2'-OMePS) to the corresponding fully modified 2'-O-methyl RNA AO (2'-OMePS) as a control...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27853883/nutritional-status-and-its-effects-on-muscle-wasting-in-patients-with-chronic-heart-failure-insights-from-studies-investigating-co-morbidities-aggravating-heart-failure
#7
Masakazu Saitoh, Marcelo Rodrigues Dos Santos, Nicole Ebner, Amir Emami, Masaaki Konishi, Junichi Ishida, Miroslava Valentova, Anja Sandek, Wolfram Doehner, Stefan D Anker, Stephan von Haehling
BACKGROUND: Inadequate nutritional status has been linked to poor outcomes in patients with heart failure (HF). Skeletal muscle wasting affects about 20% of ambulatory patients with HF. The impact of nutritional intake and appetite on skeletal muscle wasting has not been investigated so far. We sought to investigate the impact of nutritional status on muscle wasting and mortality in ambulatory patients with HF. METHODS: We studied 130 ambulatory patients with HF who were recruited as a part of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF) program...
November 16, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27792245/malnutrition-and-risk-of-structural-brain-changes-seen-on-magnetic-resonance-imaging-in-older-adults
#8
Marian A E de van der Schueren, Sabine Lonterman-Monasch, Wiesje M van der Flier, Mark H Kramer, Andrea B Maier, Majon Muller
OBJECTIVES: To study the associations between protein energy malnutrition, micronutrient malnutrition, brain atrophy, and cerebrovascular lesions. DESIGN: Cross-sectional. SETTING: Geriatric outpatient clinic. PARTICIPANTS: Older adults (N = 475; mean age 80 ± 7). MEASUREMENTS: Nutritional status was assessed using the Mini Nutritional Assessment (MNA) and according to serum micronutrient levels (vitamins B1, B6, B12, D; folic acid)...
October 28, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27791228/mini-nutritional-assessment-and-mortality-after-hip-fracture-surgery-in-the-elderly
#9
J van Wissen, M F M van Stijn, H J Doodeman, A P J Houdijk
BACKGROUND: Hip fracture surgery in elderly patients is associated with a poor postoperative outcome and a high mortality. Malnutrition is a frequent problem in elderly patients and may be associated with mortality after hip fracture surgery. The Mini Nutritional Assessment (MNA) is a valuable tool to identify malnourished patients and those at risk for malnutrition. OBJECTIVE: To evaluate the association between the preoperative MNA score and mortality after surgery for hip fractures in elderly patients...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27791222/nutritional-and-functional-status-in-geriatric-day-hospital-patients-mna-short-form-versus-full-mna
#10
E Schrader, E Grosch, T Bertsch, C C Sieber, D Volkert
OBJECTIVES: The aims of this study were to determine the prevalence of malnutrition in patients of a geriatric day hospital using the Mini Nutritional Assessment short form (MNA-SF) and the full MNA, to compare both tools, and to examine the relationship between nutritional and functional status. DESIGN: Cross-sectional study. SETTING: Geriatric day hospital. PARTICIPANTS: 190 patients (72.1% female, median 80 years) aged 65 years or older...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27776178/molecular-study-of-the-amazonian-macabea-cattle-history
#11
Julio Vargas, Vincenzo Landi, Amparo Martínez, Mayra Gómez, María Esperanza Camacho, Luz Ángela Álvarez, Lenin Aguirre, Juan Vicente Delgado
Macabea cattle are the only Bos taurus breed that have adapted to the wet tropical conditions of the Amazon. This breed has integrated into the culture of the indigenous Shuar-Asuar nations probably since its origins, being one of the few European zoogenetic resources assimilated by the deep-jungle Amazon communities. Despite its potential for local endogenous sustainable development, this breed is currently endangered. The present study used molecular genetics tools to investigate the within- and between-breeds diversity, in order to characterize the breed population, define its associations with other breeds, and infer its origin and evolution...
2016: PloS One
https://www.readbyqxmd.com/read/27775912/a-robust-motion-artifact-detection-algorithm-for-accurate-detection-of-heart-rates-from-photoplethysmographic-signals-using-time-frequency-spectral-features
#12
Duy Dao, S M A Salehizadeh, Yeon Noj, Jo Woon Chong, Chae Cho, Dave Mcmanus, Chad E Darling, Yitzhak Mendelson, Ki H Chon
Motion and noise artifacts (MNAs) impose limits on the usability of the photoplethysmogram (PPG), particularly in the context of ambulatory monitoring. MNAs can distort PPG, causing erroneous estimation of physiological parameters such as heart rate (HR) and arterial oxygen saturation (SpO2). In this study we present a novel approach, "TifMA," based on using the Time-frequency spectrum of PPG to first detect the MNA-corrupted data and next discard the non-usable part of the corrupted data. The term "non-usable" refers to segments of PPG data from which the HR signal cannot be recovered accurately...
October 21, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27749567/morbidity-and-mortality-predictivity-of-nutritional-assessment-tools-in-the-postoperative-care-unit
#13
Şule Özbilgin, Volkan Hancı, Dilek Ömür, Mücahit Özbilgin, Mine Tosun, Serhan Yurtlu, Semih Küçükgüçlü, Atalay Arkan
The aim was to evaluate the nutritional situation of patients admitted to the Postoperative Acute Care Unit using classic methods of objective anthropometry, systemic evaluation methods, and Nutrition Risk in Critically Ill (NUTRIC) score, and to compare them as a predictor of morbidity and mortality.At admission to the postoperative care unit, patients undergoing various surgeries were assessed for the following items: Subjective Global Assessment (SGA), Nutritional Risk Index (NRI), Nutritional Risk Screening (NRS)-2002, Mini Nutritional Assessment (MNA), Charlson comorbidity index (CCI), and NUTRIC score, anthropometric measurements, serum total protein, serum albumin, and lymphocyte count...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27743519/risk-factors-for-malnutrition-in-seniors-aged-75-living-in-home-environment-in-selected-regions-of-the-czech-republic
#14
Iva Brabcová, Marie Trešlová, Sylva Bártlová, Jitka Vacková, Valerie Tóthová, Lenka Motlová
BACKGROUND AND AIM: Nutrition is an important social determinant of health that influences the ageing process. The aim of this study was to evaluate the nutritional condition of a group of seniors and identify the bio-psycho-social factors that increase the risk of malnutrition. METHODS: The research was conducted using a quantitative method. The standardised scales Mini Nutritional Assessment - Short Form (MNA-SF) and the Geriatric depression scale (GDS-5) were used to evaluate the nutritional condition and tendency towards depression of the tested group...
September 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/27735837/an-improved-manufacturing-approach-for-discrete-silicon-microneedle-arrays-with-tunable-height-pitch-ratio
#15
Renxin Wang, Wei Wang, Zhihong Li
Silicon microneedle arrays (MNAs) have been widely studied due to their potential in various transdermal applications. However, discrete MNAs, as a preferred choice to fabricate flexible penetrating devices that could adapt curved and elastic tissue, are rarely reported. Furthermore, the reported discrete MNAs have disadvantages lying in uniformity and height-pitch ratio. Therefore, an improved technique is developed to manufacture discrete MNA with tunable height-pitch ratio, which involves KOH-dicing-KOH process...
October 9, 2016: Sensors
https://www.readbyqxmd.com/read/27717627/preventative-vaccines-for-zika-virus-outbreak-preliminary-evaluation
#16
Eun Kim, Geza Erdos, Shaohua Huang, Thomas Kenniston, Louis D Falo, Andrea Gambotto
Since it emerged in Brazil in May 2015, the mosquito-borne Zika virus (ZIKV) has raised global concern due to its association with a significant rise in the number of infants born with microcephaly and neurological disorders such as Guillain-Barré syndrome. We developed prototype subunit and adenoviral-based Zika vaccines encoding the extracellular portion of the ZIKV envelope gene (E) fused to the T4 fibritin foldon trimerization domain (Efl). The subunit vaccine was delivered intradermally through carboxymethyl cellulose microneedle array (MNA)...
October 3, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27714886/pharmacokinetic-and-pharmacodynamic-interaction-of-andrographolide-and-standardized-extract-of-andrographis-paniculata-nees-with-nabumetone-in-wistar-rats
#17
Aishwarya Balap, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
The aim of the study was to investigate the herb-drug interaction of Andrographis paniculata Nees (Acanthaceae) and Andrographolide (AN) with nabumetone (NAB) in wistar rats. Pharmacokinetic and pharmacodynamic interactions were studied after co-administration of APE and AN with NAB in Wistar rats. In pharmacokinetic studies, significant decrease in Cmax, AUC0-t and AUC0-∞ of 6-MNA after co-administration with pure AN and APE has been observed. Tmax of 6-MNA has been increased to 2 h from 1.5 h in AN + NAB treated group...
October 7, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27710987/prevalence-and-factors-associated-with-geriatric-malnutrition-in-an-outpatient-clinic-of-a-teaching-hospital-in-jeddah-saudi-arabia
#18
Sami Hamdan Alzahrani, Ismail Abdelmoneim El Sayed, Sarah Mohammed Alshamrani
BACKGROUND: Malnutrition is highly prevalent among the elderly and is associated with poor clinical prognosis, decreased functional status, and increased morbidity and mortality. OBJECTIVE: To estimate the prevalence of geriatric malnutrition among outpatients of a geriatric clinic and to determine factors associated with malnutrition. DESIGN: Cross-sectional study. SETTING: Geriatric outpatient clinic of the King Abdul Aziz University Hospital, Jeddah...
September 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27709237/visual-impairment-screening-at-the-geriatric-frailty-clinic-for-assessment-of-frailty-and-prevention-of-disability-at-the-g%C3%A3-rontop%C3%A3-le
#19
V Soler, S Sourdet, L Balardy, G Abellan van Kan, D Brechemier, M E Rougé-Bugat, N Tavassoli, M Cassagne, F Malecaze, F Nourhashémi, B Vellas
OBJECTIVES: To evaluate visual performance and factors associated with abnormal vision in patients screened for frailty at the Geriatric Frailty Clinic (GFC) for Assessment of Frailty and Prevention of Disability at Toulouse University Hospital. DESIGN: Retrospective, observational cross-sectional, single-centre study. SETTING: Institutional practice. PARTICIPANTS: Patients were screened for frailty during a single-day hospital stay between October 2011 and October 2014 (n = 1648)...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27709234/early-nutritional-follow-up-after-discharge-prevents-deterioration-of-adl-functions-in-malnourished-independent-geriatric-patients-who-live-alone-a-randomized-clinical-trial
#20
J L Pedersen, P U Pedersen, E M Damsgaard
OBJECTIVES: To compare the effects of two nutritional follow-up interventions with regard to preventing short-term deterioration in ADL, and to compare their effects on physical function, emotional health, and health-related quality of life. DESIGN: Randomized clinical trial with two intervention groups and one control group, and a follow-up period of eight weeks. SETTING: Intervention in the participants' homes after discharge from hospital...
2016: Journal of Nutrition, Health & Aging
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