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JOURNAL ARTICLE
Glen Pridham, Andrew D Rutenberg
Using longitudinal study data, we dynamically model how aging affects homeostasis in both mice and humans. We operationalize homeostasis as a multivariate mean-reverting stochastic process. We hypothesize that biomarkers have stable equilibrium values, but that deviations from equilibrium of each biomarker affects other biomarkers through an interaction network-this precludes univariate analysis. We therefore looked for age-related changes to homeostasis using dynamic network stability analysis, which transforms observed biomarker data into independent "natural" variables and determines their associated recovery rates...
December 13, 2023: Scientific Reports
#22
JOURNAL ARTICLE
Tatyana Zotova, Anastasia Lukanina, Mikhail Blagonravov, Veronika Tyurina, Vyacheslav Goryachev, Anna Bryk, Anastasia Sklifasovskaya, Anastasia Kurlaeva
Changes in the activity of the renin-angiotensin-aldosterone system are responsible for a stable shift in the regulation of the cardiovascular system in essential hypertension (EH). They can be characterized as hemodynamic allostasis. The purpose of our study was to determine the role of hemodynamic parameters in allostatic load in patients with EH without metabolic syndrome. Twenty-four hours of ambulatory blood pressure monitoring was performed, followed by linear and non-linear rhythm analysis. Based on the daily index, patients with EH were divided into two groups: group 1-patients with no significant nighttime decrease in blood pressure (BP); group 2-patients who had a nocturnal decrease in BP...
November 28, 2023: Diagnostics
#23
JOURNAL ARTICLE
Yukie Saka-Kochi, Kenji Kanbara, Kohei Yoshida, Fumie Kato, Sadanobu Kawashima, Tetsuya Abe, Hideaki Hasuo
Functional somatic syndromes (FSSs) represent a clinically important group of disorders that are often stress-related. Their autonomic pathophysiology, including reduced heart rate variability (HRV), has been reported. However, the response pattern to mental stress and recovery in FSSs remains unclear. Thus, we aimed to clarify the pattern of autonomic stress response and recovery to mental arithmetic stress in patients with FSS compared to that in healthy controls. This cross-sectional study included 79 patients with FSS who visited the Department of Psychosomatic Medicine at a university hospital in Japan and 39 healthy controls...
December 7, 2023: Applied Psychophysiology and Biofeedback
#24
REVIEW
Vanessa Teckentrup, Nils B Kroemer
Survival is a fundamental physiological drive, and neural circuits have evolved to prioritize actions that meet the energy demands of the body. This fine-tuning of goal-directed actions based on metabolic states ('allostasis') is deeply rooted in our brain, and hindbrain nuclei orchestrate the vital communication between the brain and body through the vagus nerve. Despite mounting evidence for vagal control of allostatic behavior in animals, its broader function in humans is still contested. Based on stimulation studies, we propose that the vagal afferent pathway supports transitions between survival modes by gating the integration of ascending bodily signals, thereby regulating reward-seeking...
November 29, 2023: Trends in Cognitive Sciences
#25
REVIEW
Jan Chodkiewicz
PURPOSE: In recent years, research has yielded new information regarding the impact of intense, long-term alcohol consumption on the development of permanent changes in the central nervous system. The present study examines the mechanisms related to the existence of addiction memory, sensitization and allostasis. A dual-process model was also created, which analyses the role of conscious and automatic mechanisms in the functioning of addicts. The aim of the article is to present these mechanisms and to consider the implications of their existence for the course of therapy...
September 2023: Postepy psychiatrii neurologii
#26
JOURNAL ARTICLE
Sejla Gubucz-Pálfalvi, Tamás Kurimay, Ildikó Danis
Alcohol use disorder and its consequences are a major public health problem not only worldwide, but in Hungary as well. The problem is aggravated by the low rate of admission to treatment, and by the high dropout rate of the treatment prior to its completion date. The relapse rate is also high, up to more than half of the patients are not able to maintain their abstinence following the first few months after their treatment. Although most patients enrolling in the addiction care system are over the age of 35, the causes of alcohol use disorder often stem from early childhood experiences...
October 15, 2023: Orvosi Hetilap
#27
Glen Pridham, Andrew D Rutenberg
Using longitudinal study data, we dynamically model how aging affects homeostasis in both mice and humans. We operationalize homeostasis as a multivariate mean-reverting stochastic process. We hypothesize that biomarkers have stable equilibrium values, but that deviations from equilibrium of each biomarker affects other biomarkers through an interaction network - this precludes univariate analysis. We therefore looked for age-related changes to homeostasis using dynamic network stability analysis, which transforms observed biomarker data into independent "natural" variables and determines their associated recovery rates...
October 23, 2023: ArXiv
#28
REVIEW
Jesse S Bettinger, Karl J Friston
Bettinger, J. S., K. J. Friston. Conceptual Foundations of Physiological Regulation incorporating the Free Energy Principle & Self-Organized Criticality. NEUROSCI BIOBEHAV REV 23(x) 144-XXX, 2022. Since the late nineteen-nineties, the concept of homeostasis has been contextualized within a broader class of "allostatic" dynamics characterized by a wider-berth of causal factors including social, psychological and environmental entailments; the fundamental nature of integrated brain-body dynamics; plus the role of anticipatory, top-down constraints supplied by intrinsic regulatory models...
December 2023: Neuroscience and Biobehavioral Reviews
#29
JOURNAL ARTICLE
Akihiro Koreki, Yuri Terasawa
The classical concept of allostasis is proposed as a dynamic adaptive capacity to stressors. The overload of allostasis results in adaptive disorders, and then lead to various psychiatric disorders. The recent concept of allostasis explains not only physiological adaptation but also behavioural changes. Furthermore, the relationship between interoception and the sense of self as well as emotion has attracted attention in recent years. These conceptual extensions and their abnormalities could help in understanding the symptoms of schizophrenia...
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#30
JOURNAL ARTICLE
Yuri Terasawa, Akihiro Koreki
Feeling emotional responses, such as heartbeat and respiration, influence subjective feeling of emotion. The role of interoception as a link in this relationship has been the focus of much attention. The predictive coding model is suggested for understanding the mechanism of interoception, and the model is also closely related to allostasis. This paper introduces a perspective on emotion from the allostasis mediated by interoception.
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#31
JOURNAL ARTICLE
Toshio Inui
Homeostasis is maintained by neural reflex controls, which attempt to maintain the body's internal organs within a predetermined range. However, when deviations are significant, homeostasis may not be restored by these standard controls. Therefore, a function called allostasis is necessary to maximize the energy efficiency of bodily functions, anticipate changing needs (e.g., a future increase in body temperature or oxygen demand), and regulate the body's state before dyshomeostasis occurs. In terms of the free energy principle (FEP), the expectation to survive (i...
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#32
REVIEW
Emi Yuda
This paper reviews patterns of heart rate variability and mechanisms of allostasis. The paper focuses on traditional autonomic nervous system and brain-heart axis research, recent biological measurements, and ambulatory electrocardiogram (ECG) big data analysis. The importance of biological measurement of daily activities and the results of data-driven research that analyzes ECG big data will provide new insights into the use of bio-signals.
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#33
JOURNAL ARTICLE
Makoto Tsuda
Lesions or diseases affecting the somatosensory system cause neuropathic pain, a debilitating chronic pain condition. From our recent study using a mouse model of neuropathic pain, CD11c+ microglia that appear in the spinal cord after nerve injury are important cells required for the pain remission. In this article, we review the transition of microglial states after nerve injury and the allostatic control mechanisms of neuropathic pain by CD11c+ microglia.
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#34
JOURNAL ARTICLE
Wataru Sato, Masayuki Kanbara
Social allostasis, the process by which social interactions dynamically regulate psychophysiological states (e.g., emotions), is attracting attention. Social allostasis can significantly impact people's mental and physical wellbeing. However, adaptive social relationships are not necessarily available to all people. The use of robots is expected to solve this problem. In this paper, we present three studies of our group that prove the influence of social interactions with robots on human psychophysiological states...
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#35
JOURNAL ARTICLE
Yuki Takayanagi, Tatsushi Onaka
Resilience is a term that describes the capacity of coping with and recovering from stress and adversity. In terms of the concept of allostasis, resilience is the ability to appropriately regulate allostasis, efficiently terminate the allostatic response, prevent the occurrence of allostatic load/overload or restore homeostasis. Recently, it has been shown that oxytocin may be involved in this series of stress adaptation systems. We aim to discuss the changes in oxytocin neuron activation, oxytocin release and its actions of stress adaptation in response to internal and external environmental changes, and the regulation of resilience by oxytocin...
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#36
JOURNAL ARTICLE
Hideki Ohira
Allostasis refers to the mechanism by which the brain changes bodily states to adapt to the environment in order to achieve stability or homeostasis. This concept was originally proposed by Sterling and Eyer in 1988. Recently, allostasis has been reconceptualized from the viewpoint of predictive processing, a theory arguing that the brain regulates perception and motor movement by generating predictions through inner models of the external world and self and minimizing the prediction error between the predictions and sensory signals...
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#37
JOURNAL ARTICLE
Hajime Mushiake
Homeostasis is a well-known physiological principle that refers to a stable internal environment. Allostasis, on the other hand, is a more recently understood physiological principle based on predictive control, in which the setpoint of the internal environment is dynamically adjusted to increase control efficiency. The concept of allostasis continues to evolve with advances in the field of neuroscience. This overview introduces some new findings and broadens the concept of allostasis to apply it to the inter-regulation of the cognitive, somatic, and autonomic nervous systems...
November 2023: Brain and Nerve, Shinkei Kenkyū No Shinpo
#38
REVIEW
Daniela Schiller, Alessandra N C Yu, Nelly Alia-Klein, Susanne Becker, Howard C Cromwell, Florin Dolcos, Paul J Eslinger, Paul Frewen, Andrew H Kemp, Edward F Pace-Schott, Jacob Raber, Rebecca L Silton, Elka Stefanova, Justin H G Williams, Nobuhito Abe, Moji Aghajani, Franziska Albrecht, Rebecca Alexander, Silke Anders, Oriana R Aragón, Juan A Arias, Shahar Arzy, Tatjana Aue, Sandra Baez, Michela Balconi, Tommaso Ballarini, Scott Bannister, Marlissa C Banta, Karen Caplovitz Barrett, Catherine Belzung, Moustafa Bensafi, Linda Booij, Jamila Bookwala, Julie Boulanger-Bertolus, Sydney Weber Boutros, Anne-Kathrin Bräscher, Antonio Bruno, Geraldo Busatto, Lauren M Bylsma, Catherine Caldwell-Harris, Raymond C K Chan, Nicolas Cherbuin, Julian Chiarella, Pietro Cipresso, Hugo Critchley, Denise E Croote, Heath A Demaree, Thomas F Denson, Brendan Depue, Birgit Derntl, Joanne M Dickson, Sanda Dolcos, Anat Drach-Zahavy, Olga Dubljević, Tuomas Eerola, Dan-Mikael Ellingsen, Beth Fairfield, Camille Ferdenzi, Bruce H Friedman, Cynthia H Y Fu, Justine M Gatt, Beatrice de Gelder, Guido H E Gendolla, Gadi Gilam, Hadass Goldblatt, Anne Elizabeth Kotynski Gooding, Olivia Gosseries, Alfons O Hamm, Jamie L Hanson, Talma Hendler, Cornelia Herbert, Stefan G Hofmann, Agustin Ibanez, Mateus Joffily, Tanja Jovanovic, Ian J Kahrilas, Maria Kangas, Yuta Katsumi, Elizabeth Kensinger, Lauren A J Kirby, Rebecca Koncz, Ernst H W Koster, Kasia Kozlowska, Sören Krach, Mariska E Kret, Martin Krippl, Kwabena Kusi-Mensah, Cecile D Ladouceur, Steven Laureys, Alistair Lawrence, Chiang-Shan R Li, Belinda J Liddell, Navdeep K Lidhar, Christopher A Lowry, Kelsey Magee, Marie-France Marin, Veronica Mariotti, Loren J Martin, Hilary A Marusak, Annalina V Mayer, Amanda R Merner, Jessica Minnier, Jorge Moll, Robert G Morrison, Matthew Moore, Anne-Marie Mouly, Sven C Mueller, Andreas Mühlberger, Nora A Murphy, Maria Rosaria Anna Muscatello, Erica D Musser, Tamara L Newton, Michael Noll-Hussong, Seth Davin Norrholm, Georg Northoff, Robin Nusslock, Hadas Okon-Singer, Thomas M Olino, Catherine Ortner, Mayowa Owolabi, Caterina Padulo, Romina Palermo, Rocco Palumbo, Sara Palumbo, Christos Papadelis, Alan J Pegna, Silvia Pellegrini, Kirsi Peltonen, Brenda W J H Penninx, Pietro Pietrini, Graziano Pinna, Rosario Pintos Lobo, Kelly L Polnaszek, Maryna Polyakova, Christine Rabinak, S Helene Richter, Thalia Richter, Giuseppe Riva, Amelia Rizzo, Jennifer L Robinson, Pedro Rosa, Perminder S Sachdev, Wataru Sato, Matthias L Schroeter, Susanne Schweizer, Youssef Shiban, Advaith Siddharthan, Ewa Siedlecka, Robert C Smith, Hermona Soreq, Derek P Spangler, Emily R Stern, Charis Styliadis, Gavin B Sullivan, James E Swain, Sébastien Urben, Jan Van den Stock, Michael A Vander Kooij, Mark van Overveld, Tamsyn E Van Rheenen, Michael B VanElzakker, Carlos Ventura-Bort, Edelyn Verona, Tyler Volk, Yi Wang, Leah T Weingast, Mathias Weymar, Claire Williams, Megan L Willis, Paula Yamashita, Roland Zahn, Barbra Zupan, Leroy Lowe
Over the last decades, theoretical perspectives in the interdisciplinary field of the affective sciences have proliferated rather than converged due to differing assumptions about what human affective phenomena are and how they work. These metaphysical and mechanistic assumptions, shaped by academic context and values, have dictated affective constructs and operationalizations. However, an assumption about the purpose of affective phenomena can guide us to a common set of metaphysical and mechanistic assumptions...
March 2024: Neuroscience and Biobehavioral Reviews
#39
REVIEW
Rohit Menon, Inga D Neumann
Many social behaviours are evolutionarily conserved and are essential for the healthy development of an individual. The neuropeptide oxytocin (OXT) is crucial for the fine-tuned regulation of social interactions in mammals. The advent and application of state-of-the-art methodological approaches that allow the activity of neuronal circuits involving OXT to be monitored and functionally manipulated in laboratory mammals have deepened our understanding of the roles of OXT in these behaviours. In this Review, we discuss how OXT promotes the sensory detection and evaluation of social cues, the subsequent approach and display of social behaviour, and the rewarding consequences of social interactions in selected reproductive and non-reproductive social behaviours...
December 2023: Nature Reviews. Neuroscience
#40
JOURNAL ARTICLE
Jaden Penhaskashi, Olivia Sekimoto, Francesco Chiappelli
The immune system, an exquisitely regulated physiological system, utilizes a wide spectrum of soluble factors and multiple cell populations and subpopulations at diverse states of maturation to monitor and protect the organism against foreign organisms. Immune surveillance is ensured by distinguishing self-antigens from self-associated with non-self (e.g., viral) peptides presented by major histocompatibility complexes (MHC). Pathology is often identified as unregulated inflammatory responses (e.g., cytokine storm), or recognizing self as a non-self entity (i...
2023: Bioinformation
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