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Tipping point

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https://www.readbyqxmd.com/read/28925736/chronological-changes-in-tip-cells-during-sprouting-angiogenesis-of-development-of-the-retinal-vasculature-in-newborn-mice
#1
Chang Sik Cho, Sang-Mok Lee, Byung Joo Lee, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim, Young Suk Yu
PURPOSE: To investigate a sequential chronological change in tip cells during the development of the retinal vasculature in newborn mice. MATERIALS AND METHODS: Newborn C57BL/6 mice were used for this study. To elucidate the patterns in the developing retinal vasculature, histology, and immunohistochemistry-antiplatelet endothelial cell adhesion molecule-1, anticollagen type IV, isolectin IB4-were performed on sections of mouse retina on postnatal days (P)-4, -8, and -12...
September 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28924020/microindentation-a-tool-for-measuring-cortical-bone-stiffness-a-systematic-review
#2
M Arnold, S Zhao, S Ma, F Giuliani, U Hansen, J P Cobb, R L Abel, O Boughton
OBJECTIVES: Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. The question addressed with this systematic review is whether microindentation can accurately measure cortical bone stiffness. METHODS: A systematic review of all English language articles using a keyword search was undertaken using Medline, Embase, PubMed, Scopus and Cochrane databases...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28922078/the-tipping-point-of-change-in-an-qualitative-findings-from-an-online-study
#3
Sarah Fogarty, Lucie M Ramjan
OBJECTIVE: The aim of this study was to understand factors related to treatment and/or recovery from self-reported Anorexia Nervosa, including 'the tipping point of change'. METHOD: An online questionnaire was developed and administered from December 2014 to December 2015 to individuals ≥18 years of age with Anorexia Nervosa in the past or currently who were recruited through eating disorder organizations in Australia and the United Kingdom. Responses to a specific qualitative question on 'the tipping point of change' were analyzed using conventional content analysis...
September 18, 2017: Women & Health
https://www.readbyqxmd.com/read/28920963/tuning-a-circular-p-n-junction-in-graphene-from-quantum-confinement-to-optical-guiding
#4
Yuhang Jiang, Jinhai Mao, Dean Moldovan, Massoud Ramezani Masir, Guohong Li, Kenji Watanabe, Takashi Taniguchi, Francois M Peeters, Eva Y Andrei
The photon-like propagation of the Dirac electrons in graphene, together with its record-high electronic mobility, can lead to applications based on ultrafast electronic response and low dissipation. However, the chiral nature of the charge carriers that is responsible for the high mobility also makes it difficult to control their motion and prevents electronic switching. Here, we show how to manipulate the charge carriers by using a circular p-n junction whose size can be continuously tuned from the nanometre to the micrometre scale...
September 18, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28913733/a-prospective-feasibility-trial-of-a-novel-intravascular-catheter-system-with-retractable-coiled-tip-guidewire-placed-in-difficult-intravascular-access-diva-patients-in-the-emergency-department
#5
Christopher Raio, Robert Elspermann, Natwalee Kittisarapong, Brendon Stankard, Tanya Bajaj, Veena Modayil, Mathew Nelson, Gerardo Chiricolo, Benjamin Wie, Alexandra Snock, Michael Mackay, Adam Ash
The primary study objective was to evaluate insertion success rates. Secondary objectives included patient satisfaction, procedure time, complication rates, completion of therapy and dwell time of the novel AccuCath(®) 2.25″ Blood Control (BC) Catheter System (FDA approved) placed in difficult-access patients. This was a single-arm feasibility trial evaluating the AccuCath(®) 2.25″ BC Catheter System in a convenience sample of DIVA patients defined as at least two failed initial attempts or a history of difficult access plus the inability to directly visualize or palpate a target vein...
September 14, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28912453/measuring-critical-transitions-in-financial-markets
#6
Jan Jurczyk, Thorsten Rehberg, Alexander Eckrot, Ingo Morgenstern
Tipping points in complex systems are structural transitions from one state to another. In financial markets these critical points are connected to systemic risks, which have led to financial crisis in the past. Due to this, researchers are studying tipping points with different methods. This paper introduces a new method which bridges the gap between real-world portfolio management and statistical facts in financial markets in order to give more insight into the mechanics of financial markets.
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911792/facial-profile-and-frontal-changes-after-bimaxillary-surgery-in-patients-with-mandibular-prognathism
#7
Chun-Ming Chen, Michael Yuan-Chien Chen, Jung-Hsuan Cheng, Kwei-Jing Chen, Yu-Chuan Tseng
BACKGROUND/PURPOSE: Patients are always concerned about their postoperative appearance before surgery for facial deformity correction. The present study investigated the facial profile and frontal changes following two-jaw surgery. METHODS: Forty patients who underwent two-jaw surgery were divided by the amount of mandibular setback (group I: ≤8 mm and group II: >8 mm). Cephalometric radiograms (lateral and frontal) were collected and analyzed at three intervals: preoperatively (T1), immediately postoperatively (T2), and final follow-up (T3)...
September 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28910491/a-double-epsps-gene-mutation-endowing-glyphosate-resistance-shows-a-remarkably-high-resistance-cost
#8
Heping Han, Martin M Vila-Aiub, Adam Jalaludin, Qin Yu, Stephen B Powles
A novel glyphosate resistance double point mutation (T102I/P106S, TIPS) in the 5-enolpyruvylshikimate-3 phosphate synthase (EPSPS) gene has been recently identified for the first time only in the weed species Eleusine indica. Quantification of plant resistance cost associated with the TIPS and the often reported glyphosate resistance single P106S mutation was performed. A significant resistance cost (50% in seed number currency) associated with the homozygous TIPS but not the homozygous P106S EPSPS variant was identified in E...
September 14, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28904899/virtue-quadratic-male-sling-for-stress-incontinence-surgical-guide-for-placement-and-delayed-revision
#9
REVIEW
Rachel S Rubin, Keith R Xavier, Eugene Rhee
The algorithm for surgical management of post prostatectomy incontinence classically includes male slings and artificial urinary sphincter (AUS) placement. The Virtue Quadratic Male Sling was designed to provide both urethral elevation and prepubic compression making it a viable option for a wider spectrum of incontinent men whose symptoms range from mild to severe. With a focus on two key steps of the surgery, (I) sling fixation (II) use of intraoperative retrograde leak point pressure (RLPP), this guide is intended to outline a safe and efficacious treatment for post-prostatectomy incontinence...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28902876/postoperative-lead-migration-in-deep-brain-stimulation-surgery-incidence-risk-factors-and-clinical-impact
#10
Takashi Morishita, Justin D Hilliard, Michael S Okun, Dan Neal, Kelsey A Nestor, David Peace, Alden A Hozouri, Mark R Davidson, Francis J Bova, Justin M Sporrer, Genko Oyama, Kelly D Foote
INTRODUCTION: Deep brain stimulation (DBS) is an effective treatment for multiple movement disorders and shows substantial promise for the treatment of some neuropsychiatric and other disorders of brain neurocircuitry. Optimal neuroanatomical lead position is a critical determinant of clinical outcomes in DBS surgery. Lead migration, defined as an unintended post-operative displacement of the DBS lead, has been previously reported. Despite several reports, however, there have been no systematic investigations of this issue...
2017: PloS One
https://www.readbyqxmd.com/read/28902592/tipping-point-for-patent-foramen-ovale-closure
#11
EDITORIAL
Allan H Ropper
New England Journal of Medicine, Volume 377, Issue 11, Page 1093-1095, September 2017.
September 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28894099/statistical-modelling-predicts-almost-complete-loss-of-major-periglacial-processes-in-northern-europe-by-2100
#12
Juha Aalto, Stephan Harrison, Miska Luoto
The periglacial realm is a major part of the cryosphere, covering a quarter of Earth's land surface. Cryogenic land surface processes (LSPs) control landscape development, ecosystem functioning and climate through biogeochemical feedbacks, but their response to contemporary climate change is unclear. Here, by statistically modelling the current and future distributions of four major LSPs unique to periglacial regions at fine scale, we show fundamental changes in the periglacial climate realm are inevitable with future climate change...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28892407/nonparametric-bootstrap-technique-for-calibrating-surgical-smartforceps-theory-and-application
#13
Parisa Azimaee, Mohammad Jafari Jozani, Yaser Maddahi, Kourosh Zareinia, Garnette R Sutherland
Knowledge of forces, exerted on the brain tissue during the performance of neurosurgical tasks, is critical for quality assurance, case rehearsal, and training purposes. Quantifying the interaction forces has been made possible by developing SmartForceps, a bipolar forceps retrofitted by a set of strain gauges. The forces are estimated using voltages read from strain gauges. We therefore need to quantify the force-voltage relationship to estimate the interaction forces during microsurgery. This problem has been addressed in the literature by following the physical and deterministic properties of the force-sensing strain gauges without obtaining the precision associated with each estimate...
September 11, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28892109/the-effect-of-stm-parameters-on-tip-enhanced-raman-spectra
#14
Natalia Martín Sabanés, Amala Elizabeth, Jonas H K Pfisterer, Katrin F Domke
In this work, we evaluate the dependence of tip-enhanced Raman (TER) spectra of a monolayer of thiophenol at a Au(111) electrode on the scanning tunneling microscope's tunneling current set-point and bias voltage parameters. We find an increase of the TER intensity upon set-point increase or bias decrease as expected from a gap-distance reduction. The relations obtained follow a theoretical model considering a simple gap-distance change when tuning the mentioned parameters. We find that the value of the bias voltage affects the TER intensity to a larger extent than the current set-point...
September 11, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28882379/reliable-anatomical-landmarks-for-minimizing-leg-length-discrepancy-during-hip-arthroplasty-using-the-lateral-transgluteal-approach-for-femoral-neck-fracture
#15
Jeung Il Kim, Nam Hoon Moon, Won Chul Shin, Kuen Tak Suh, Jae Yoon Jeong
BACKGROUND: The purpose of this study was to describe our experience of a preoperative templating technique, and to investigate the most reliable anatomical reference to minimize leg length discrepancy (LLD) during hip arthroplasty using the lateral transgluteal approach for femoral neck fractures. We hypothesized that the medial fracture tip and greater trochanter would be viable alternative anatomical References METHODS: A total of 156 hip arthroplasty cases were enrolled in the present study (103 women, 114 hemiarthroplasties, 42 total hip arthroplasties)...
September 1, 2017: Injury
https://www.readbyqxmd.com/read/28881257/the-length-of-pre-existing-fissures-effects-on-the-mechanical-properties-of-cracked-red-sandstone-and-strength-design-in-engineering
#16
Jiangyu Wu, Meimei Feng, Bangyong Yu, Guansheng Han
It is important to study the mechanical properties of cracked rock to understand the engineering behavior of cracked rock mass. Consequently, the influence of the length of pre-existing fissures on the strength, deformation, acoustic emission (AE) and failure characteristics of cracked rock specimen was analyzed, and the optimal selection of strength parameter in engineering design was discussed. The results show that the strength parameters (stress of dilatancy onset and uniaxial compressive strength) and deformation parameters (axial strain and circumferential strain at dilatancy onset and peak point) of cracked rock specimen decrease with the increase of the number of pre-existing fissures, and the relations which can use the negative exponential function to fit...
August 30, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28877282/two-point-discrimination-values-vary-depending-on-test-site-sex-and-test-modality-in-the-orofacial-region-a-preliminary-study
#17
Sang-Yeun Won, Hye-Kyoung Kim, Mee-Eun Kim, Ki-Suk Kim
Objective: The aims of the present study were to determine the normal values of TPD in the six trigeminal sites (the forehead, cheek, mentum, upper lip, lower lip, and the tongue tip) and to investigate the effect of the site, sex, and test modality on the TPD perception. Material and Methods: Forty healthy volunteers consisting of age-matched men (20) and women (20) with a mean age of 27.1 years were recruited. One examiner performed the TPD test using a simple hand-operated device, i...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28874307/prosthetic-mitral-valve-paravalvular-leak-a-problem-that-requires-dexterity
#18
James W Hansen, Gautam Gadey, Thomas C Piemonte
Prosthetic valve paravalvular leak (PVL) is a known and relatively common complication of surgical valve replacement, which may lead to significant morbidity. Patients with significant mitral valve replacement (MVR) PVL typically present with symptoms of heart failure and elevated filling pressures or with hemolytic anemia. Percutaneous closure of these leaks has become the preferred therapy. Percutaneous closure of MVR PVL can be technically challenging, given the anatomy of the approach (trans-septal, trans-apical), the level of associated comorbidities and the geographic location of the paravalvular defect...
July 24, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28874167/forecasting-infectious-disease-emergence-subject-to-seasonal-forcing
#19
Paige B Miller, Eamon B O'Dea, Pejman Rohani, John M Drake
BACKGROUND: Despite high vaccination coverage, many childhood infections pose a growing threat to human populations. Accurate disease forecasting would be of tremendous value to public health. Forecasting disease emergence using early warning signals (EWS) is possible in non-seasonal models of infectious diseases. Here, we assessed whether EWS also anticipate disease emergence in seasonal models. METHODS: We simulated the dynamics of an immunizing infectious pathogen approaching the tipping point to disease endemicity...
September 6, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28871013/understanding-symptom-appraisal-and-help-seeking-in-people-with-symptoms-suggestive-of-pancreatic-cancer-a-qualitative-study
#20
Katie Mills, Linda Birt, Jon D Emery, Nicola Hall, Jonathan Banks, Margaret Johnson, John Lancaster, William Hamilton, Greg P Rubin, Fiona M Walter
OBJECTIVE: Pancreatic cancer has poor survival rates due to non-specific symptoms leading to later diagnosis. Understanding how patients interpret their symptoms could inform approaches to earlier diagnosis. This study sought to explore symptom appraisal and help-seeking among patients referred to secondary care for symptoms suggestive of pancreatic cancer. DESIGN: Qualitative analysis of semistructured in-depth interviews. Data were analysed iteratively and thematically, informed by the Model of Pathways to Treatment...
September 3, 2017: BMJ Open
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