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https://www.readbyqxmd.com/read/28748911/a-novel-and-quick-pcr-based-method-to-genotype-mice-with-a-leptin-receptor-mutation-db-db-mice
#1
Bao-Yu Peng, Qiang Wang, Yan-Hong Luo, Jian-Feng He, Tao Tan, Hua Zhu
db/db mice is one of most widely used animal models in studying the cellular and molecular mechanisms of metabolic disorders, such as diabetes, hyperlipidemia, and obesity. The mice carry spontaneous point mutations in the gene encoding the leptin receptor, leading to leptin receptor inactivation. Since homozygous db/db mice are sterile, the maintenance of db/db mice requires breeding between heterozygous pairs, which makes genotyping essential for the identification of offspring. The aim of this study was to develop a quick and highly repeatable method for genotyping db/db mice, which comprised only three simple steps: Genomic DNA is extracted from either tail tips or ear notches via alkaline lysis (∼20 min); Samples are then subjected to tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) using specially designed and validated primer sets (∼1...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28744991/utility-of-high-density-multielectrode-mapping-during-ablation-of-scar-related-ventricular-tachycardia
#2
Óscar Cano, Diego Plaza, Assumpció Saurí, Joaquín Osca, Pau Alonso, Ana Andrés, María-José Sancho-Tello, Luis Martínez-Dolz
INTRODUCTION: Multielectrode mapping catheters (MEMC) allow the performance of high resolution and density maps but the utility of these catheters in ventricular tachycardia (VT) ablation procedures has not been yet widely described. We sought to evaluate the utility of a MEMC during scar-related VT ablation procedures. METHODS: 85 consecutive scar-related VT ablation procedures were performed in 81 patients. In the first 26 procedures, a standard 3.5 mm tip linear catheter was employed for endocardial/epicardial mapping (control group)...
July 26, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28742610/near-point-of-convergence-and-gait-deficits-in-adolescents-after-sport-related-concussion
#3
David R Howell, Michael J OʼBrien, Aparna Raghuram, Ankoor S Shah, William P Meehan
OBJECTIVE: To prospectively examine gait characteristics of participants acutely after concussion with and without receded near point of convergence (NPC), compared with healthy controls. DESIGN: Cross-sectional study. SETTING: Sports-medicine clinic. PARTICIPANTS: Patients examined after concussion (n = 33; mean ± SD = 7.2 ± 3.1 days) and a group of uninjured athletes (n = 31) completed a Postconcussion Symptom Scale, underwent NPC testing, and single/dual-task gait assessments...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28741904/prevention-of-childhood-obesity-and-food-policies-in-latin-america-from-research-to-practice
#4
R Pérez-Escamilla, C K Lutter, C Rabadan-Diehl, A Rubinstein, A Calvillo, C Corvalán, C Batis, E Jacoby, S Vorkoper, L Kline, E Ewart-Pierce, J A Rivera
BACKGROUND: Addressing childhood obesity in Latin America requires a package of multisectoral, evidence-based policies that enable environments conducive to healthy lifestyles. OBJECTIVE: Identify and examine key elements to translating research into effective obesity policies in Latin America. METHODS: We examined obesity prevention policies through case studies developed with an expert in the specific policy. Policies were selected based on their level of implementation, visibility and potential impact to reduce childhood obesity...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28736124/implications-of-three-dimensional-modeling-of-the-proximal-femur-for-cephalomedullary-nailing-an-asian-cadaver-study
#5
Chang-Soo Chon, Bokku Kang, Han Sung Kim, Gu-Hee Jung
PURPOSE: To determine the variability in the ideal entry point of cephalomedullary (CM) nail around the greater trochanter (GT) and the consequent conformity with the proximal femur by analyzing three-dimensional (3D) modeling and virtual implantation MATERIALS AND METHODS: A total of 105 cadaveric femurs (50 males and 55 females) underwent continuous 1.0mm slice computed tomography (CT) scans. CT images imported into Mimics(®) software to reconstruct the 3D model of the proximal femur and medullary canal...
July 11, 2017: Injury
https://www.readbyqxmd.com/read/28732265/chronic-work-stress-and-decreased-vagal-tone-impairs-decision-making-and-reaction-time-in-jockeys
#6
Kathleen Landolt, Paul Maruff, Ben Horan, Michael Kingsley, Glynda Kinsella, Paul D O'Halloran, Matthew W Hale, Bradley J Wright
The inverse relationship between acute stress and decision-making is well documented, but few studies have investigated the impact of chronic stress. Jockeys work exhaustive schedules and have extremely dangerous occupations, with safe performance requiring quick reaction time and accurate decision-making. We used the effort reward imbalance (ERI) occupational stress model to assess the relationship of work stress with indices of stress physiology and decision-making and reaction time. Jockeys (N=32) completed computerised cognitive tasks (Cogstate) on two occasions; September and November (naturally occurring lower and higher stress periods), either side of an acute stress test...
July 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28732159/remote-single-molecule-switching-identification-and-nano-engineering-of-hot-electron-induced-tautomerization
#7
Jens Kügel, Markus Leisegang, Markus Böhme, Andreas Krönlein, Aimee Sixta, Matthias Bode
Molecular electronics where single molecules perform basic functionalities of digital circuits is a fascinating concept that one day may augment or even replace nowadays semiconductor technologies. The tautomerization of molecules, i.e., the bistable functional position of hydrogen protons within an organic frame, has recently been intensively discussed as a potential avenue towards nano-scale switches. It has been shown that tautomerization can be triggered locally or non-locally, i.e. by a scanning tunneling microscope (STM) tip positioned directly above or in close vicinity to the molecule...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28729793/assessment-of-consistency-in-the-dimension-of-gutta-percha-cones-of-protaper-next-and-waveone-with-their-corresponding-number-files
#8
Nitika Bajaj, Prashant Monga, Pardeep Mahajan
OBJECTIVES: To compare the dimensions of gutta-percha (GP) cones of ProTaper Next (25/0.06) and WaveOne (25/0.08) in relation to their corresponding instruments of the same dimension, respectively. MATERIALS AND METHODS: Two groups of GP cones were made with 25 cones in each group. Group 1 consisted of 25 GP cones # 25/0.06 (ProTaper Next). Group 2 consisted of 25 GP cones # 25/0.08 (WaveOne). Measurements were done at D1 (1 mm short of the tip), D3 (3 mm short of the tip), and D11 (11 mm short of the tip) for GP cones of both groups and were compared with their corresponding instruments...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28727793/effect-of-child-marriage-on-girls-school-dropout-in-nepal-analysis-of-data-from-the-multiple-indicator-cluster-survey-2014
#9
Kazutaka Sekine, Marian Ellen Hodgkin
School dropout and child marriage are interrelated outcomes that have an enormous impact on adolescent girls. However, the literature reveals gaps in the empirical evidence on the link between child marriage and the dropout of girls from school. This study identifies the 'tipping point' school grades in Nepal when the risk of dropout due to marriage is highest, measures the effect of child marriage on girls' school dropout rates, and assesses associated risk factors. Weighted percentages were calculated to examine the grades at highest risk and the distribution of reasons for discontinuing school...
2017: PloS One
https://www.readbyqxmd.com/read/28727586/moisture-balance-the-tipping-point
#10
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28727493/sibilant-production-in-hebrew-speaking-adults-apical-versus-laminal
#11
Michal Icht, Boaz M Ben-David
The Hebrew IPA charts describe the sibilants /s, z/ as 'alveolar fricatives', where the place of articulation on the palate is the alveolar ridge. The point of constriction on the tongue is not defined - apical (tip) or laminal (blade). Usually, speech and language pathologists (SLPs) use the apical placement in Hebrew articulation therapy. Some researchers and SLPs suggested that acceptable /s, z/ could be also produced with the laminal placement (i.e. the tip of the tongue approximating the lower incisors)...
July 20, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28726265/how-to-havest-the-greatest-length-of-tibialis-posterior-tendon-in-tibialis-posterior-tendon-transfer-a-cadaveric-study
#12
Korakot Thamphongsri, Thos Harnroongroj, Atthakorn Jarusriwanna, Bavornrit Chuckpaiwong
INTRODUCTION: In anterior transfer of the tibialis posterior tendon, the tendon was harvested using two incisions, the first at its attachment point on the navicular bone and second on the medial side of the leg above the medial malleolus. To provide the maximum tendon length, the second incision needs to be as proximal as possible but injury to the muscle origin must be avoided. The purpose of this study is to establish the location of the second incision that yields the greatest tendon length...
July 20, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28725285/free-will-black-swans-and-addiction
#13
Ted Fenton, Reinout W Wiers
The current dominant perspective on addiction as a brain disease has been challenged recently by Marc Lewis, who argued that the brain-changes related to addiction are similar to everyday changes of the brain. From this alternative perspective, addictions are bad habits that can be broken, provided that people are motivated to change. In that case, autonomous choice or "free will" can overcome bad influences from genes and or environments and brain-changes related to addiction. Even though we concur with Lewis that there are issues with the brain disease perspective, we also argue that pointing to black swans can be important, that is: there can be severe cases where addiction indeed tips over into the category of brain disease, but obviously that does not prove that every case of addiction falls into the disease category, that all swans are black...
2017: Neuroethics
https://www.readbyqxmd.com/read/28721521/expression-patterns-of-the-native-shrunken-2-promoter-in-sorghum-bicolor-visualised-through-use-of-the-gfp-reporter-gene
#14
Kyle C Lamont, Stephen R Mudge, Guoquan Liu, Ian D Godwin
The AGPase large subunit (shrunken-2) promoter was demonstrated to be active in the placentochalaza and endosperm of developing grain as well as the root tips in transgenic sorghum. The temporal and spatial expression patterns of the Sorghum bicolor Shrunken-2 (Sh2) promoter were evaluated using the green fluorescence protein reporter gene (gfp) in transgenic sorghum, within the context of upregulating starch biosynthesis in the developing grain. GFP fluorescence was analysed throughout development in various tissue types using confocal laser scanning microscopy techniques...
July 18, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28715542/simultaneous-analysis-of-elastic-and-non-specific-adhesive-properties-of-thin-sample-and-biological-cell-considering-bottom-substrate-effect
#15
Viswanath Managuli, Sitikantha Roy
A new asymptotically correct contact model has been developed for conical tip based AFM nanoindentation. This new model provides both elastic and non-specific adhesion properties of cells and soft gels by taking sample thickness at the point of indentation and its depth of indentation into consideration. The bottom substrate effect is the most common source of error in the study of "AFM force maps" of the cellular sample. The present model incorporates an asymptotically correct correction term as a function of depth of indentation to eliminate the substrate effect in the analysis...
July 17, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28714857/comparative-analysis-on-resistance-profiling-along-tapered-semiconductor-nanowires-multi-tip-technique-vs-transmission-line-method
#16
Andreas Nägelein, Lisa Liborius, Matthias Steidl, Christian Blumberg, Peter Kleinschmidt, Artur Poloczek, Thomas Hannappel
The detection of doping dependent values like contact- and path resistances along nanowires (NWs) still proves to be rather challenging compared to planar structures. Unfortunately, the usually used and well established TLM (transmission line measurement) setup exhibits some drawbacks. Complex preliminary preparation steps and the necessity of ohmic contacts limit the investigation to certain semiconductor materials. The simultaneous determination of contact- and path resistances with an unknown distribution makes an analysis on complex structures like tapered nanowires very challenging...
July 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28710708/the-bridge-between-design-and-analysis
#17
Jimmie Leppink, Patricia O'Sullivan, Kal Winston
The overall purpose of the 'Statistical Points and Pitfalls' series is to help readers and researchers alike increase awareness of how to use statistics and why/how we fall into inappropriate choices or interpretations. We hope to help readers understand common misconceptions and give clear guidance on how to avoid common pitfalls by offering simple tips to improve your reporting of quantitative research findings. Each entry discusses a commonly encountered inappropriate practice and alternatives from a pragmatic perspective with minimal mathematics involved...
July 14, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28710678/breast-magnetic-resonance-imaging-tips-for-the-diagnosis-of-silicone-induced-granuloma-of-a-breast-implant-capsule-sigbic
#18
REVIEW
Eduardo de Faria Castro Fleury, Ana Claudia Gianini, Veronica Ayres, Luciana C Ramalho, Rodrigo Oliveira Seleti, Decio Roveda
Complications resulting from the placement of silicone breast implants are becoming more frequent in our clinical practice. This is due to the increase in breast aesthetic surgeries at the beginning of the century, where breast augmentation using silicone implants was the main intervention performed. Generally, studies that discuss the complications of breast implants are restricted to reports of intra- or extra-capsular ruptures, contractures and haematomas. Currently, much importance has been given to anaplastic large cell lymphoma (ALCL) as a more severe complication related to silicone implants...
August 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28709676/fracture-load-of-complete-arch-implant-supported-prostheses-reinforced-with-nylon-silica-mesh-an-in%C3%A2-vitro-study
#19
Fernanda de Cássia Papaiz Gonçalves, Marina Amaral, Alexandre Luiz Souto Borges, Luiz Fernando Martins Gonçalves, Tarcisio José de Arruda Paes-Junior
STATEMENT OF PROBLEM: Complete-arch implant-supported prostheses without a framework have a high risk of failure: a straightforward and inexpensive reinforcement material, such as nylon mesh, could improve their longevity. PURPOSE: The purpose of this in vitro study was to evaluate a nylon-silica mesh compound on the fracture strength of acrylic resin and the fracture load of complete-arch implant-supported prostheses. MATERIAL AND METHODS: Twenty-four complete mandibular arch implant-supported prostheses were divided into 2 groups according to cantilever length (molar and premolar) and subdivided into another 2 subgroups according to the presence or absence of reinforcing mesh...
July 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28709194/effects-of-communication-burstiness-on-consensus-formation-and-tipping-points-in-social-dynamics
#20
C Doyle, B K Szymanski, G Korniss
Current models for opinion dynamics typically utilize a Poisson process for speaker selection, making the waiting time between events exponentially distributed. Human interaction tends to be bursty though, having higher probabilities of either extremely short waiting times or long periods of silence. To quantify the burstiness effects on the dynamics of social models, we place in competition two groups exhibiting different speakers' waiting-time distributions. These competitions are implemented in the binary naming game and show that the relevant aspect of the waiting-time distribution is the density of the head rather than that of the tail...
June 2017: Physical Review. E
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