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https://www.readbyqxmd.com/read/28631331/missing-data-in-clinical-trials-control-based-mean-imputation-and-sensitivity-analysis
#1
Devan V Mehrotra, Fang Liu, Thomas Permutt
In some randomized (drug versus placebo) clinical trials, the estimand of interest is the between-treatment difference in population means of a clinical endpoint that is free from the confounding effects of "rescue" medication (e.g., HbA1c change from baseline at 24 weeks that would be observed without rescue medication regardless of whether or when the assigned treatment was discontinued). In such settings, a missing data problem arises if some patients prematurely discontinue from the trial or initiate rescue medication while in the trial, the latter necessitating the discarding of post-rescue data...
June 20, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28627621/identification-of-different-macrophage-subpopulations-with-distinct-activities-in-a-mouse-model-of-oxygen-induced-retinopathy
#2
Yanji Zhu, Ling Zhang, Qing Lu, Yushuo Gao, Yujuan Cai, Ailing Sui, Ting Su, Xi Shen, Bing Xie
The aim of the present study was to characterize the phenotypic shift, quantity and role changes in different subgroups of retinal macrophages in a mouse model of oxygen-induced retinopathy (OIR). The mRNA expression levels of macrophage M1 and M2 subgroup marker genes and polarization-associated genes were analyzed by RT-qPCR. The number of M1 and M2 macrophages in our mouse model of OIR was analyzed by flow cytometry at different time points during the progression of OIR. Immunofluorescence whole mount staining of the retinas of mice with OIR was performed at different time points to examine the influx of macrophages, as well as the morphological characteristics and roles of M1 and M2 macrophages...
June 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28626862/acoustic-field-characterization-of-a-clinical-magnetic-resonance-guided-high-intensity-focused-ultrasound-system-inside-the-magnet-bore
#3
Satya V V N Kothapalli, Michael B Altman, Ari Partanen, Leighton Wan, H Michael Gach, William Straube, Dennis E Hallahan, Hong Chen
PURPOSE: With the expanding clinical application of magnetic resonance-guided high intensity focused ultrasound (MR-HIFU), acoustic field characterization of MR-HIFU systems is needed for facilitating regulatory approval and ensuring consistent and safe power output of HIFU transducers. However, the established acoustic field measurement techniques typically use equipment that cannot be used in a magnetic resonance imaging (MRI) suite, thus posing a challenge to the development and execution of HIFU acoustic field characterization techniques...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28616274/remedial-localization-after-dislodgement-of-primary-mechanical-localization-in-lung-surgery
#4
Long Wang, Xufeng Zhang, Mu Li, Xiermaimaiti Kadeer, Chenyang Dai, Zhe Shi, Chang Chen
BACKGROUND: Unhooking or displacement of hookwire or microcoil due to technical failures is rather common. We aim to establish a new technique for remedial localization in the case of displacement or unhooking of primary mechanical localization during lung surgery. METHODS: From February 2014 to September 2015, 18 consecutive cases of intraoperative dislodgement during video-assisted thoracoscopic surgery (VATS) were enrolled. Nodule's projection on body surface was located by analyzing computed tomography (CT) images, and a needle was inserted into thoracic cavity through this point...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28612670/optimal-approach-for-complete-liver-tumor-ablation-using-radiofrequency-ablation-a-simulation-study
#5
Sogol Givehchi, Yin How Wong, Chai Hong Yeong, Basri Johan Jeet Abdullah
PURPOSE: To investigate the effect of radiofrequency ablation (RFA) electrode trajectory on complete tumor ablation using computational simulation. MATERIAL AND METHODS: The RFA of a spherical tumor of 2.0 cm diameter along with 0.5 cm clinical safety margin was simulated using Finite Element Analysis software. A total of 86 points inside one-eighth of the tumor volume along the axial, sagittal and coronal planes were selected as the target sites for electrode-tip placement...
June 14, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28611962/clinical-results-of-complex-subtrochanteric-femoral-fractures-with-long-cephalomedullary-hip-nail
#6
Kwang-Kyoun Kim, Yougun Won, Danica H Smith, Gi-Soo Lee, Hee Young Lee
PURPOSE: Good results of the cephalomedullary nails have been reported in proximal femoral fractures recently. Based on length of nails and shape of screws fixed in a femoral head for proximal fragment fixation, the proper nail length was in dispute. The purpose of this study was to evaluate the clinical and radiological results of a long cephalomedullary hip nail for the treatment of comminuted subtrochanteric femoral fractures. MATERIALS AND METHODS: Twenty-one consecutive patients with severe subtrochanteric femoral fractures who had undergone intramedullary fixation using long-PFNA II between March 2010 and March 2013 were followed-up for over 12 months...
June 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28611797/characterization-and-regulation-of-aquaporin-genes-of-sorghum-sorghum-bicolor-l-moench-in-response-to-waterlogging-stress
#7
Suhas Kadam, Alejandra Abril, Arun P Dhanapal, Robert P Koester, Wilfred Vermerris, Shibu Jose, Felix B Fritschi
Waterlogging is a significant environmental constraint to crop production, and a better understanding of plant responses is critical for the improvement of crop tolerance to waterlogged soils. Aquaporins (AQPs) are a class of channel-forming proteins that play an important role in water transport in plants. This study aimed to examine the regulation of AQP genes under waterlogging stress and to characterize the genetic variability of AQP genes in sorghum (Sorghum bicolor). Transcriptional profiling of AQP genes in response to waterlogging stress in nodal root tips and nodal root basal regions of two tolerant and two sensitive sorghum genotypes at 18 and 96 h after waterlogging stress imposition revealed significant gene-specific pattern with regard to genotype, root tissue sample, and time point...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28611000/the-sterility-of-selected-operative-sites-during-total-laparoscopic-hysterectomy
#8
Marie E Shockley, Benjamin Beran, Heather Nutting, Katrin Arnolds, Michael L Sprague, Stephen Zimberg
STUDY OBJECTIVE: To describe the type and quantity of bacteria found intraoperatively on the abdomen, vagina, surgical gloves, instrument tips, and uterus at distinct time points during total laparoscopic hysterectomy (TLH). DESIGN: Observational study (Canadian Task Force classification III) SETTING: Academic affiliated hospital PATIENTS: 31 women undergoing TLH for benign indications in 2016 INTERVENTIONS: After antibiotic prophylaxis and chlorhexidine preparation, swabs were collected from the vaginal fornices and abdomen...
June 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28610140/three-new-i-batillipes-i-species-arthrotardigrada-batillipedidae-from-the-brazilian-coast
#9
Erika Santos, Clélia M C DA Rocha, Edivaldo Jr Gomes, Paulo Fontoura
Three new tardigrade species, Batillipes brasiliensis sp. nov., Batillipes dandarae sp. nov. and Batillipes potiguarensis sp. nov., are described from shallow subtidal sediments of the Brazilian coast. B. brasiliensis sp. nov. and B. dandarae sp. nov. have toes 3 and 4 on leg IV different in length, so they can be included in the D group of species, while B. potiguarensis sp. nov., with toes 3 and 4 on leg IV equal in length belong to the A group. Batillipes brasiliensis sp. nov. is characterized by having an ala-like caudal expansion; cuticular projections on the coxal region of legs I-III, and lateral projections...
March 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608718/apocalypse-now
#10
Michael T Rupp
Despite the wishful thinking of those who have long prophesied an imminent surge in demand for clinical pharmacists, the tipping point for healthy supply-demand balance in pharmacy has almost certainly been surpassed. Imprudent overbuilding of pharmacy programs has combined with trends toward increasing automation and consolidation in pharmacy practice to create an existential threat in pharmacy education. Surviving the looming industry shakeout will require schools and colleges of pharmacy to do what our colleagues in practice and the private sector have always done: compete...
June 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28607062/biomechanical-coupling-facilitates-spinal-neural-tube-closure-in-mouse-embryos
#11
Gabriel L Galea, Young-June Cho, Gauden Galea, Matteo A Molè, Ana Rolo, Dawn Savery, Dale Moulding, Lucy H Culshaw, Evanthia Nikolopoulou, Nicholas D E Greene, Andrew J Copp
Neural tube (NT) formation in the spinal region of the mammalian embryo involves a wave of "zippering" that passes down the elongating spinal axis, uniting the neural fold tips in the dorsal midline. Failure of this closure process leads to open spina bifida, a common cause of severe neurologic disability in humans. Here, we combined a tissue-level strain-mapping workflow with laser ablation of live-imaged mouse embryos to investigate the biomechanics of mammalian spinal closure. Ablation of the zippering point at the embryonic dorsal midline causes far-reaching, rapid separation of the elevating neural folds...
June 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28606330/recognition-of-children-on-age-different-images-facial-morphology-and-age-stable-features
#12
Zuzana Caplova, Valentina Compassi, Silvio Giancola, Daniele M Gibelli, Zuzana Obertová, Pasquale Poppa, Remo Sala, Chiarella Sforza, Cristina Cattaneo
The situation of missing children is one of the most emotional social issues worldwide. The search for and identification of missing children is often hampered, among others, by the fact that the facial morphology of long-term missing children changes as they grow. Nowadays, the wide coverage by surveillance systems potentially provides image material for comparisons with images of missing children that may facilitate identification. The aim of study was to identify whether facial features are stable in time and can be utilized for facial recognition by comparing facial images of children at different ages as well as to test the possible use of moles in recognition...
July 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28601630/risk-factors-for-cut-out-failure-of-gamma3-nails-in-treating-unstable-intertrochanteric-fractures-an-analysis-of-176-patients
#13
Shang-Wen Tsai, Chien-Fu Jeff Lin, Yun-Hsuan Tzeng, Chun-Cheng Lin, Ching-Kuei Huang, Ming-Chau Chang, Chao-Ching Chiang
BACKGROUND: Cut-out failure is one of the most common complications in the Gamma3 nail fixation system. The purpose of this retrospective study was to determine pre-operative or intra-operative risk factors for cut-out failure of lag screws in unstable, intertrochanteric fractures fixed with short Gamma3 nails. METHODS: One hundred and seventy-six patients over 60 years of age, with unstable intertrochanteric fractures (AO/OTA 31-A2, 31-A3) treated with short Gamma3 nails were included in this study...
June 7, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28601561/the-3dbiopsy-prostate-biopsy-system-preclinical-investigation-of-a-needle-actuator-and-specimen-collection-device-allowing-sampling-of-individualized-prostate-lengths-between-20-and-60-mm
#14
Nelson N Stone, Vladimir Mouraviev, David Schechter, M Scott Lucia, Elizabeth E Smith, Paul Arangua, John Hoenemeyer, Jim Rosa, Rajan Bawa, E David Crawford
OBJECTIVE: To increase the likelihood of detecting anterior cancers within the prostate and provide a specimen that spans the length of the gland. Newly designed 17- and 15-gauge (G) biopsy needles, a variable actuator and integrated pathology system intended for the longer cores were developed and tested for this purpose. MATERIALS AND METHODS: Testing was performed comparing two common cannula tip grinds, a Vet-point (sharp tip) and Menghini-point (atraumatic tip) and were tested against 18-G Bard MonoptyTM in porcine kidney...
June 7, 2017: Urology
https://www.readbyqxmd.com/read/28598430/vegetation-recovery-in-tidal-marshes-reveals-critical-slowing-down-under-increased-inundation
#15
Jim van Belzen, Johan van de Koppel, Matthew L Kirwan, Daphne van der Wal, Peter M J Herman, Vasilis Dakos, Sonia Kéfi, Marten Scheffer, Glenn R Guntenspergen, Tjeerd J Bouma
A declining rate of recovery following disturbance has been proposed as an important early warning for impending tipping points in complex systems. Despite extensive theoretical and laboratory studies, this 'critical slowing down' remains largely untested in the complex settings of real-world ecosystems. Here, we provide both observational and experimental support of critical slowing down along natural stress gradients in tidal marsh ecosystems. Time series of aerial images of European marsh development reveal a consistent lengthening of recovery time as inundation stress increases...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28597843/dynamical-predictors-of-an-imminent-phenotypic-switch-in-bacteria
#16
Huijing Wang, Christian Ray
Single cells can stochastically switch across thresholds imposed by regulatory networks. Such thresholds can act as a tipping point, drastically changing global phenotypic states. In ecology and economics, imminent transitions across such tipping points can be predicted using dynamical early warning indicators. A typical example is "flickering" of a fast variable, predicting a longer-lasting switch from a low to a high state or vice versa. Considering the different timescales between metabolite and protein fluctuations in bacteria, we hypothesized that metabolic early warning indicators predict imminent transitions across a network threshold caused by enzyme saturation...
June 9, 2017: Physical Biology
https://www.readbyqxmd.com/read/28595164/imaging-and-analysis-of-individual-cavitation-microbubbles-around-dental-ultrasonic-scalers
#17
N Vyas, H Dehghani, R L Sammons, Q X Wang, D M Leppinen, A D Walmsley
Cavitation is a potentially effective and less damaging method of removing biofilm from biomaterial surfaces. The aim of this study is to characterise individual microbubbles around ultrasonic scaler tips using high speed imaging and image processing. This information will provide improved understanding on the disruption of dental biofilm and give insights into how the instruments can be optimised for ultrasonic cleaning. Individual cavitation microbubbles around ultrasonic scalers were analysed using high speed recordings up to a million frames per second with image processing of the bubble movement...
May 24, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28594917/taxicab-tipping-and-sunlight
#18
Srikant Devaraj, Pankaj C Patel
Does the level of sunlight affect the tipping percentage in taxicab rides in New York City? We examined this question using data on 13.82 million cab rides from January to October in 2009 in New York City combined with data on hourly levels of solar radiation. We found a small but statistically significant positive relationship between sunlight and tipping, with an estimated tipping increase of 0.5 to 0.7 percentage points when transitioning from a dark sky to full sunshine. The findings are robust to two-way clustering of standard errors based on hour-of-the-day and day-of-the-year and controlling for day-of-the-year, month-of-the-year, cab driver fixed effects, weather conditions, and ride characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28589120/a-crispr-new-world-attitudes-in-the-public-toward-innovations-in-human-genetic-modification
#19
Steven M Weisberg, Daniel Badgio, Anjan Chatterjee
The potential to genetically modify human germlines has reached a critical tipping point with recent applications of CRISPR-Cas9. Even as researchers, clinicians, and ethicists weigh the scientific and ethical repercussions of these advances, we know virtually nothing about public attitudes on the topic. Understanding such attitudes will be critical to determining the degree of broad support there might be for any public policy or regulation developed for genetic modification research. To fill this gap, we gave an online survey to a large (2,493 subjects) and diverse sample of Americans...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28583450/intraprocedural-rupture-of-unruptured-cerebral-aneurysms-during-coil-embolization-a-single-center-experience
#20
Su Hee Cho, Mohammed Denewer, Won Hyong Park, Jae Sung Ahn, Byung Duk Kwun, DeokHee Lee, Jung Cheol Park
OBJECTIVE: The incidence of intraprocedural rupture (IPR) during endovascular coiling is reported to range from 2% to 5%. In this study, we reviewed the single center experiences of IPR during coil embolization for unruptured intracranial aneurysm. METHODS: At our institution, 849 patients were treated with endovascular therapy for unruptured intracranial aneurysm between January 2011 and April 2016. Ten (1.18%) of these patients had documented IPR. We reviewed the medical data to evaluate the characteristics of the aneurysms, angiographic findings related to rupture, management, and outcomes...
June 2, 2017: World Neurosurgery
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