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Interleukin-2

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https://www.readbyqxmd.com/read/28315535/high-dose-interleukin-2-evaluation-of-a-standardized-order-set-for-biotherapy-in-an-intensive-care-unit%C3%A2
#1
Rusticio Portillas, Barbara Turner, Audrey Jeffers, Lee-Lynn Chen, Mary Champagne
BACKGROUND: Life-threatening toxicity may result from administration of high-dose (HD) interleukin-2 (IL-2). Patients receiving HD IL-2 treatment often experience severe adverse side effects, which result in the interruption of treatment. 
. OBJECTIVES: A standardized order set (SOS) was developed for patients with melanoma or renal cell carcinoma receiving HD IL-2. The aims of the study were to determine compliance of clinicians to the SOS, report the completed doses and major side effects of HD IL-2, and document the satisfaction level of clinicians...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28306530/ascorbic-acid-does-not-modulate-potassium-currents-in-cultured-human-lymphocytes
#2
Saravanakumar Snekalatha, Praghalathan Kanthakumar
BACKGROUND: Ascorbic acid (AA) is known to modulate lymphocyte function, but the mechanism of action is not clearly understood. As voltage-gated potassium currents play an important role in lymphocyte function, the effect of AA on voltage-gated potassium currents was studied. METHODS: Peripheral blood mononuclear cells were cultured in the presence of increasing concentrations of AA (0, 0.125, 0.25, 0.5, and 1 mM). Potassium currents in resting lymphocytes were studied by whole cell patch clamp technique using a depolarizing protocol...
March 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28295528/serum-soluble-interleukin-2-receptor-level-is-more-sensitive-than-angiotensin-converting-enzyme-or-lysozyme-for-diagnosis-of-sarcoidosis-and-may-be-a-marker-of-multiple-organ-involvement
#3
Chuyen Thi Hong Nguyen, Naotomo Kambe, Izumi Kishimoto, Ikuko Ueda-Hayakawa, Hiroyuki Okamoto
Skin lesions in sarcoidosis are often the initial symptoms that enable the dermatologist to be the first to diagnose this granulomatosis. However, diagnosis is sometimes very problematic. In 2015, the diagnostic criteria for sarcoidosis were updated in Japan, with elevated serum soluble interleukin-2 receptor (sIL-2R) replacing negative tuberculin reaction. Therefore, we assessed the clinical utility of sIL-2R compared with two other common markers, angiotensin-converting enzyme (ACE) and lysozyme, in patients who visited the dermatology clinic...
March 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28294085/serum-cytokine-profile-of-laryngeal-squamous-cell-carcinoma-patients
#4
J Sotirović, A Perić, D Vojvodić, N Baletić, I Zaletel, I Stanojević, M Erdoglija, M Milojević
OBJECTIVES: This study aimed to evaluate serum cytokine concentrations in healthy individuals and laryngeal squamous cell carcinoma patients. METHODS: A total of 59 laryngeal squamous cell carcinoma patients and 44 healthy controls were included. Multiplex analysis of interleukins 2, 4, 5, 6, 10, 12, 13 and 17 and interferon-gamma with respect to the presence of laryngeal carcinoma, tumour-node-metastasis T stage, nodal involvement and larynx subsite was performed...
March 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28290822/-immunological-analysis-of-human-atherosclerotic-plaques-in-ex-vivo-culture-system
#5
D A Vorobyova, A M Lebedev, M S Vagida, O I Ivanova, E I Felker, V N Gontarenko, A V Shpektor, L B Margolis, E Yu Vasilieva
THE AIM OF THE STUDY: to analyze the dynamics of lymphocytic composition of human atherosclerotic plaques in ex vivo culture system. MATERIALS AND METHODS: The study included 15 atherosclerotic plaques obtained from patients who underwent carotid endarterectomy. Plaques were cultured as ring-shaped explants on collagen rafts in culture medium of special composition in CO2 incubator according to the previously developed technique. On day 0, and also on the 4th and 19th days of culture we extracted cells from plaque explants and analyzed B- and T-lymphocytic content of the tissue, as well as the percentage of CD16+ natural killer (NK) cells, using multichromatic flow cytometry...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28288839/the-role-of-high-dose-interleukin-2-in-the-era-of-targeted-therapy
#6
Jessie Gills, William P Parker, Scott Pate, Sida Niu, Peter Van Veldhuizen, Moben Mirza, Jeffery M Holzbeierlein, Eugene K Lee
OBJECTIVE: To assess survival outcomes following high dose IL-2 (HDIL-2) in a contemporary cohort of patients during the era of targeted agents. METHODS: Retrospective review of metastatic RCC patients treated with HDIL-2 between July 2007 and September 2014. Clinicopathologic data were abstracted and patient response to therapy was based on RECIST v1.1 criteria. The Kaplan-Meier method was used to estimate progression-free survival (PFS) and overall survival (OS) for the entire cohort, response to HDIL-2 in regards to previous targeted agent therapy, and response to targeted agent in relationship to response to HDIL-2...
March 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28282218/immunotoxins-in-cancer-therapy-review-and-update
#7
Bahman Akbari, Safar Farajnia, Shiva Ahdi Khosroshahi, Fatemeh Safari, Mohammadreza Yousefi, Hassan Dariushnejad, Leila Rahbarnia
Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused to a targeting moiety. Various toxic agents from different sources are used in immunotoxin development, including bacterial, plant and human origin cytotoxic elements. Although bacterial and plant-derived toxins are highly toxic and commonly used in immunotoxins, their immunogenicity for human restricted their application in cancer therapy. Here, we discuss the advantages and limitations of bacterial toxins such as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes...
March 1, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28275903/correlations-of-kynurenic-acid-3-hydroxykynurenine-sil-2r-ifn-%C3%AE-and-il-4-with-clinical-symptoms-during-acute-relapse-of-schizophrenia
#8
Kinga Szymona, Barbara Zdzisińska, Hanna Karakuła-Juchnowicz, Tomasz Kocki, Martyna Kandefer-Szerszeń, Marta Flis, Wojciech Rosa, Ewa M Urbańska
Several lines of evidence suggest that up-regulation of immune response and alterations of kynurenine pathway function are involved in pathogenesis of schizophrenia. Correlations among clinical status (using PANNS, SANS and SAPS scales) and blood levels of kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK) and levels of selected immunoactive molecules, soluble interleukin-2 receptor (sIL-2R), interferon-α (IFN-α) and IL-4 were analyzed in 51 chronic schizophrenia patients during acute relapse, after four weeks of therapy and at remission...
March 8, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28274688/interleukin-2-and-interleukin-10-function-synergistically-to-promote-cd8-t-cell-cytotoxicity-which-is-suppressed-by-regulatory-t-cells-in-breast-cancer
#9
Xiaogang Li, Ping Lu, Bo Li, Wanfu Zhang, Rong Yang, Yan Chu, Kaiyuan Luo
The precise role of interleukin (IL)-10 in breast cancer is not clear. Previous studies suggested a tumor-promoting role of IL-10 in breast cancer, whereas recent discoveries that IL-10 activated and expanded tumor-resident CD8(+) T cells challenged the traditional view. Here, we investigated the role of IL-10 in HLA-A2-positive breast cancer patients with Grade III, Stage IIA or IIB in-situ and invasive ductal carcinoma, and compared it with that of IL-2, the canonical CD8(+) T cell growth factor. We first observed that breast cancer patients presented higher serum levels of IL-2 and IL-10 than healthy controls...
March 5, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28274048/evaluation-of-cyclosporine-a-with-%C3%AE-tcp-in-the-treatment-of-human-infra-bony-defects-a-randomized-controlled-pilot-study
#10
Jyotsna Amalakara, Krishnajaneya Reddy, Haritha Avula, Ashank Mishra, Butchibabu Kalakonda, Ruchi Pandey
INTRODUCTION: Cyclosporine A (CsA), an immunosuppressant, is considered a life saver drug in organ transplant cases. It has also been tested in animal and human studies for periodontal applications as it selectively inhibits T lymphocyte proliferation, Interleukin-2 (IL-2) and other cytokine production, without any effect on T suppressor cells, thereby suppressing the cell mediated immunity and suppressing the inflammation. Inflammatory and immunological responses have been found to be decreased and bone formation is found to be increased in immunosuppressed animals...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28268223/interleukin-2-and-interleukin-8-gene-polymorphisms-and-acquired-aplastic-anemia-risk-in-a-chinese-population
#11
Xuejie Zhang, Shengyun Lin, Yan Yang, Liucheng Rong, Guangsheng He, Hailong He, Yao Xue, Yongjun Fang, Yaping Wang
BACKGROUND/AIMS: Cytokines IL-2 and IL-8 both participate in immune regulation. However, the relationship between polymorphisms in these two cytokines and the risk of acquired aplastic anemia (acquired AA) has not been explored. METHODS: We selected five SNPs including rs11575812, rs2069772 and rs2069762 of IL-2, rs2227306 and rs2227543 of IL-8. SNaPshot genotyping was used to test the genotypes of IL-2 and IL-8 polymorphisms in a population of 101 acquired AA patients and 165 healthy controls...
March 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28262413/checkmate-025-randomized-phase-3-study-outcomes-by-key-baseline-factors-and-prior-therapy-for-nivolumab-versus-everolimus-in-advanced-renal-cell-carcinoma
#12
Bernard Escudier, Padmanee Sharma, David F McDermott, Saby George, Hans J Hammers, Sandhya Srinivas, Scott S Tykodi, Jeffrey A Sosman, Giuseppe Procopio, Elizabeth R Plimack, Daniel Castellano, Howard Gurney, Frede Donskov, Katriina Peltola, John Wagstaff, Thomas C Gauler, Takeshi Ueda, Huanyu Zhao, Ian M Waxman, Robert J Motzer
BACKGROUND: The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR). OBJECTIVE: To investigate which baseline factors were associated with OS and ORR benefit with nivolumab versus everolimus. DESIGN, SETTING, AND PARTICIPANTS: Subgroup OS analyses were performed using Kaplan-Meier methodology...
March 2, 2017: European Urology
https://www.readbyqxmd.com/read/28249615/secondary-hemophagocytic-lymphohistiocytosis-in-the-setting-of-metastatic-renal-cell-carcinoma-a-case-report
#13
Monica El-Masry, Lauren Eisenbud, Minh-Ha Tran
BACKGROUND: Hemophagocytic lymphohistiocytosis is a disease process characterized by unregulated hyperactivation of the immune system associated with multiorgan involvement and high mortality rates. Early recognition is crucial and a recently validated diagnostic schema, the H-Score, may facilitate diagnosis particularly in secondary hemophagocytic lymphohistiocytosis cases. We present a patient with secondary hemophagocytic lymphohistiocytosis in association with metastatic renal cell carcinoma in whom high-dose steroid therapy induced a remarkable response...
March 2, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28245398/-clinical-significance-of-serum-midkine-in-children-with-henoch-schonlein-purpura
#14
Mo-Min Li, Ni Liu, Miao Zhagn, Hai-Rong Xue
OBJECTIVE: To investigate the clinical significance of serum midkine (MK) in children with henoch-schnlein purpura(HSP). METHODS: One hundred and six children with HSP admitted in our hospital from March 2013 to March 2016 were enrolled in HSP group, but then 80 healthy volunteers were used as control. MK, interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor (TNF), interferon γ (IFN-γ) and IL-17 in peripheral blood were measured by ELISA, biochemical indicators including white blood cell count (WBC), platelet (Plt), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), D-dimer, immunoglobulin A (IgA), IgE, IgG, IgM and other clinical data were recorded and analyzed...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28243360/immune-profile-of-obese-people-and-in-vitro-effects-of-red-grape-polyphenols-on-peripheral-blood-mononuclear-cells
#15
COMPARATIVE STUDY
Thea Magrone, Emilio Jirillo, Anna Spagnoletta, Manrico Magrone, Matteo Antonio Russo, Sergio Fontana, Flavia Laforgia, Ilaria Donvito, Angelo Campanella, Franco Silvestris, Giovanni De Pergola
The in vitro ability of polyphenols, extracted from red grape, to modulate peripheral blood mononuclear cell responses has been evaluated in 20 obese (Ob) people. With regard to cytokine release in response to phorbol myristate acetate (PMA), levels of interleukin-2 (IL-2), interferon-γ (IFN-γ), IL-4, IL-10, and IL-17 were higher in the Ob than in healthy (H) subjects. Vice versa, IL-21 concentrations were detected only in H people but they were undetectable in the Ob counterpart. In general terms, levels of IL-1β, IL-6, IL-8, and tumor necrosis factor-α were higher in Ob people when compared to H controls...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28242522/targeting-the-programmed-death-1-pathway-in-lymphoid-neoplasms
#16
REVIEW
Chi Young Ok, Ken H Young
Programmed death-1 (PD-1) is a co-inhibitory molecule and is seen in CD4+ and CD8+ T cells. Upon binding to its ligands, programmed death ligand-1 (PD-L1) and -2 (PD-L2), PD-1 negatively regulates interleukin 2 (IL-2) production and T cell proliferation. Activated effector T-cells, which kill cancer cells, can be affected by PD-1 signaling in some lymphoid neoplasm that express PD-L1 or PD-L2. PD-L1 expression in tumor cells can be induced by extrinsic signal (i.e. interferon gamma) or intrinsic signals, such as genetic aberrations involving 9p24...
March 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28238270/effects-of-trimetazidine-on-interleukin-2-and-interleukin-8-concentrations-in-patients-with-coronary-artery-disease
#17
Aleksander Danikiewicz, Janusz Szkodziński, Bartosz Hudzik, Ilona Korzonek-Szlacheta, Mariusz Gasior, Barbara Zubelewicz-Szkodzińska
Trimetazidine (TMZ) exhibits metabolic and cardioprotective effects. The aim of this study was to access the effects of TMZ on IL-2 and IL-8 serum concentrations in 156 patients with stable coronary artery disease. They underwent treadmill exercise test (TET) before and after 3-month TMZ treatment. IL-2 and IL-8 concentrations were determined before and after each TET. Before treatment, TET didn't influence IL-2 concentrations, whereas IL-8 concentrations increased. TMZ treatment led to a decrease in IL-2 concentrations before TET, as well as it made the observed difference in IL-8 concentrations become statistically insignificant following the second TET...
February 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28231569/biomarkers-in-autoimmune-salivary-gland-disorders-a-review
#18
Benedikt Hofauer, Klaus Thuermel, Constanze Gahleitner, Andreas Knopf
Salivary glands are frequent sites of manifestations of autoimmune disorders in the head and neck. Sjögren syndrome, sarcoidosis, granulomatosis with polyangiitis, and IgG4-related sialadenitis represent the most important autoimmune salivary gland disorders. Due to the lack of specific symptoms, diagnosis of these conditions remains a challenge. Diagnosis is usually based on classification criteria involving clinical tests, histopathological evaluation, and serological examinations. Depending on the disease, biomarkers are of different value and have to be interpreted carefully...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28230639/mammalian-target-of-rapamycin-inhibition-clinical-transplantation-liver
#19
Björn Nashan
The evidence base concerning use of mammalian target of rapamycin (mTOR) inhibitor therapy after liver transplantation is evolving rapidly, clarifying their benefits and disadvantages in different clinical scenarios. The H2304 trial showed that starting everolimus at 1 month posttransplant, with reduced tacrolimus, achieves a sustained improvement in renal function versus standard tacrolimus-based therapy, with at least equivalent immunosuppressive efficacy. Randomized studies evaluating early discontinuation of CNI therapy after introduction of an mTOR inhibitor consistently demonstrated a substantial improvement in renal function versus standard CNI therapy...
February 23, 2017: Transplantation
https://www.readbyqxmd.com/read/28222071/combination-of-the-histone-deacetylase-inhibitor-vorinostat-with-bevacizumab-in-patients-with-clear-cell-renal-cell-carcinoma-a-multicentre-single-arm-phase-i-ii-clinical-trial
#20
Roberto Pili, Glenn Liu, Sreenivasulu Chintala, Hendrick Verheul, Shabnam Rehman, Kristopher Attwood, Martin A Lodge, Richard Wahl, James I Martin, Kiersten Marie Miles, Silvia Paesante, Remi Adelaiye, Alejandro Godoy, Serina King, James Zwiebel, Michael A Carducci
BACKGROUND: Class II histone deacetylase (HDAC) inhibitors induce hypoxia-inducible factor-1 and -2α degradation and have antitumour effects in combination with vascular endothelial growth factor (VEGF) inhibitors. In this study, we tested the safety and efficacy of the HDAC inhibitor vorinostat and the VEGF blocker bevacizumab in metastatic clear-cell renal cell carcinoma (ccRCC) patients previously treated with different drugs including sunitinib, sorafenib, axitinib, interleukin-2, interferon, and temsirolimus...
February 21, 2017: British Journal of Cancer
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