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https://www.readbyqxmd.com/read/29683937/patient-s-breast-perception-after-mastectomy-analysis-of-outcomes-in-208-patients-with-breast-q-following-mastectomy-alone-implant-of-tissue-expander-and-definitive-breast-reconstruction
#1
Mauro Barone, Annalisa Cogliandro, Antonella Grasso, Vittorio Altomare, Paolo Persichetti
No abstract text is available yet for this article.
March 31, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29668679/similarities-and-differences-between-helminth-parasites-and-cancer-cell-lines-in-shaping-human-monocytes-insights-into-parallel-mechanisms-of-immune-evasion
#2
Prakash Babu Narasimhan, Leor Akabas, Sameha Tariq, Naureen Huda, Sasisekhar Bennuru, Helen Sabzevari, Robert Hofmeister, Thomas B Nutman, Roshanak Tolouei Semnani
A number of features at the host-parasite interface are reminiscent of those that are also observed at the host-tumor interface. Both cancer cells and parasites establish a tissue microenvironment that allows for immune evasion and may reflect functional alterations of various innate cells. Here, we investigated how the phenotype and function of human monocytes is altered by exposure to cancer cell lines and if these functional and phenotypic alterations parallel those induced by exposure to helminth parasites...
April 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29668510/gauze-impregnated-with-quaternary-ammonium-salt-reduces-bacterial-colonization-of-surgical-drains-after-breast-reconstruction
#3
Amy L Strong, Emily T Wolfe, Nina Shank, Abigail E Chaffin, David A Jansen
Surgical site infection after breast reconstruction is associated with increased length of hospital stay, readmission rates, cost, morbidity, and mortality. Identifying methods to reduce surgical site infection without the use of antibiotics may be beneficial at reducing antimicrobial resistance, reserving the use of antibiotics for more severe cases. Quaternary ammonium salts have previously been shown to be a safe and effective antimicrobial agent in the setting of in vitro and in vivo animal experiments...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29664622/multi-stimuli-responsive-amphiphilic-poly-ester-urethane-nano-assemblies-based-on-l-tyrosine-for-intracellular-drug-delivery-to-cancer-cells
#4
Rajendra Aluri, Sonashree Saxena, Dheeraj Chandra Joshi, Manickam Jayakannan
Multi-stimuli-responsive L-tyrosine based amphiphilic poly(ester-urethane)s nano-carriers were designed and developed, for the first time, to administrate anticancer drugs at cancer tissue environment via thermo-responsiveness and lysosomal enzymatic-biodegradation from single polymer platform. For this purpose, multifunctional L-tyrosine monomer was tailor-made with PEG-lated side chain at the phenolic position along with urethane and carboxylic ester functionalities. Under melt dual ester-urethane polycondensation, the tyrosine-monomer reacted with diols to produce high molecular weight amphiphilic poly(ester-urethane)s...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29663320/predictors-of-complications-after-direct-to-implant-breast-reconstruction-with-an-acellular-dermal-matrix-from-a-multicentre-randomized-clinical-trial
#5
V L Negenborn, R E G Dikmans, M B Bouman, H A H Winters, J W R Twisk, P Q Ruhé, M A M Mureau, J M Smit, S Tuinder, J Hommes, Y Eltahir, N A S Posch, J M van Steveninck-Barends, M A Meesters-Caberg, R R W J van der Hulst, M J P F Ritt, M G Mullender
BACKGROUND: In the multicentre randomized trial BRIOS (Breast Reconstruction In One Stage), direct-to-implant (DTI) breast reconstruction with an acellular dermal matrix (ADM) was associated with a markedly higher postoperative complication rate compared with two-stage tissue expander/implant breast reconstruction. This study aimed to identify factors that contribute to the occurrence of complications after DTI ADM-assisted breast reconstruction. METHODS: Data were obtained from the BRIOS study, including all patients treated with DTI ADM-assisted breast reconstruction...
April 16, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29663271/regenerative-potential-and-inflammation-induced-secretion-profile-of-human-adipose-derived-stromal-vascular-cells-are-influenced-by-donor-variability-and-prior-breast-cancer-diagnosis
#6
Adrienne M Parsons, Deborah M Ciombor, Paul Y Liu, Eric M Darling
Adipose tissue contains a heterogeneous population of stromal vascular fraction (SVF) cells that work synergistically with resident cell types to enhance tissue healing. Ease of access and processing paired with therapeutic promise make SVF cells an attractive option for autologous applications in regenerative medicine. However, inherent variability in SVF cell therapeutic potential from one patient to another hinders prognosis determination for any one person. This study investigated the regenerative properties and inflammation responses of thirteen, medically diverse human donors...
April 16, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29660760/racial-disparities-in-postmastectomy-breast-reconstruction-national-trends-in-utilization-from-2005-to-2014
#7
Sherise Epstein, Bao N Tran, Justin B Cohen, Samuel J Lin, Dhruv Singhal, Bernard T Lee
BACKGROUND: Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify women who underwent mastectomy and/or breast reconstruction from 2005 to 2014. Patient demographics were recorded, and cases were grouped by reconstructive status and technique...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29659450/aseptic-freeze-dried-vs-sterile-wet-packaged-human-cadaveric-acellular-dermal-matrix-adm-in-immediate-tissue-expander-breast-reconstruction-a-propensity-score-analysis-study
#8
Summer E Hanson, Jesse D Meaike, Jesse C Selber, Jun Liu, Liang Li, Victor J Hassid, Donald P Baumann, Charles E Butler, Patrick B Garvey
BACKGROUND: Although multiple acellular dermal matrix (ADM) sources exist, it is unclear how ADM processing impacts complication rates. We compared complications between two preparations of human cadaveric ADM (freeze dried [hADM-FD] and ready to use [hADM-RTU]) in immediate tissue expander (TE) breast reconstruction to analyze the effect of processing on complications. HADM-FD is aseptic while hADM-RTU is sterilized and wet-packaged. METHODS: We retrospectively reviewed all TE breast reconstructions with hADM-FD or hADM-RTU at a single center between 2006 and 2016...
January 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29651400/management-of-a-case-of-mucor-colonization-in-breast-tissue-expander-seroma-pocket
#9
Danielle N Atwood, Pallavi A Kumbla, Brian Yuen, James C Yuen
Mucormycosis has a mortality rate reaching 90%, and is imperative that therapy be initiated rapidly once a diagnosis is made. Successful treatment consists of management of underlying risk factors, surgical debridement, and antifungal therapies. The dilemma whether or not to pursue extensive debridement presents when the wound is cultured positive but the patient is not systemically ill. We present the first reported case of successful medical treatment of a seroma pocket colonized with mucor in a patient undergoing bilateral reconstruction with tissue expander and acellular dermal matrix...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29644522/bioinformatic-analysis-reveals-the-key-pathways-and-genes-in-early-onset-breast-cancer
#10
Chuanlong Cui, Lun Li, Jing Zhen
Early-onset breast cancer is the most prevalent cancer in the female. To identify the differentially expressed genes and the key signaling pathways in early-onset breast cancer, we have carried out the bioinformatic analysis of an RNA array dataset in the GEO database, GSE109169, which was acquired from early-onset breast cancer patient. A total of 118 differentially expressed genes in early-onset breast cancer were significantly changed compared with that in adjacent normal tissues. Most of these genes are classified into three categories: signaling molecule, enzyme modulator, and hydrolase...
April 11, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29623151/nipple-areolar-complex-reconstruction-a-review-of-the-literature-and-introduction-of-the-rectangle-to-cube-nipple-flap
#11
Joshua T Henderson, Thomas J Lee, Andrew M Swiergosz, Andrea R Hiller, Joshua Choo, Bradon J Wilhelmi
Objective : There are many approaches to nipple-areola complex reconstruction. Tissue quality and thickness, desired nipple location and size, scar position, and surgeon preference all play a role in selecting a technique. We present the rectangle-to-cube nipple flap, a new technique for challenging nipple reconstruction. A review of published techniques is compared and contrasted with this flap design. Methods : Following bilateral total skin-sparing mastectomies, a patient with breast cancer underwent breast reconstruction with tissue expanders and subsequent nipple reconstruction with the rectangle-to-cube nipple flap...
2018: Eplasty
https://www.readbyqxmd.com/read/29620551/practical-applications-of-delayed-immediate-autologous-breast-reconstruction-a-flexible-and-safe-operative-strategy
#12
Gloria R Sue, Arhana Chattopadhyay, Chao Long, Eva Huis 't Veld, Gordon K Lee
BACKGROUND: Timing is an important consideration in patients undergoing mastectomy for breast cancer. While immediate reconstruction results in superior aesthetic outcomes, the need for postmastectomy radiation can often only be ascertained after review of surgical pathology. Delayed-immediate autologous reconstruction (DIAR) is a reconstructive approach that consists of mastectomy with tissue expander placement in the first stage and flap-based breast reconstruction in the second stage...
April 3, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29603586/modeling-of-the-metallic-port-in-breast-tissue-expanders-for-photon-radiotherapy
#13
Jihyung Yoon, Yibo Xie, David Heins, Rui Zhang
The purpose of this study was to model the metallic port in breast tissue expanders and to improve the accuracy of dose calculations in a commercial photon treatment planning system (TPS). The density of the model was determined by comparing TPS calculations and ion chamber (IC) measurements. The model was further validated and compared with two widely used clinical models by using a simplified anthropomorphic phantom and thermoluminescent dosimeters (TLD) measurements. Dose perturbations and target coverage for a single postmastectomy radiotherapy (PMRT) patient were also evaluated...
March 30, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29595721/trends-in-physician-payments-for-breast-reconstruction
#14
Clifford C Sheckter, Day Yi, Hina J Panchal, Shantanu N Razdan, Andrea L Pusic, Colleen M McCarthy, Peter G Cordeiro, Joseph J Disa, Babak Mehrara, Evan Matros
BACKGROUND: Prosthetic breast reconstruction rates have risen in the United States, whereas autologous techniques have stagnated. Meanwhile, single-institution data demonstrate that physician payments for prosthetic reconstruction are rising, while payments for autologous techniques are unchanged. This study aims to assess payment trends and variation for tissue expander and free flap breast reconstruction. METHODS: The Blue Health Intelligence database was queried from 2009 to 2013, identifying women with claims for breast reconstruction...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29595716/sientra-allox2-short-term-case-study-surgical-pearls-and-roundtable-discussion
#15
Kamakshi R Zeidler, Peter J Capizzi, Troy A Pittman
BACKGROUND: The AlloX2 Breast Tissue Expander (Sientra, Santa Barbara, Calif.) is a unique device that contains a second port to allow for transdermal communication with the pocket around the implant. The injection dome of this expander contains two ports; one is used for traditional saline injection, and a new second port facilitates fluid drainage from the periprosthetic space through an integral drain. The AlloX2 allows for the treatment of seromas and diagnostic fluid sampling to identify bacteria and hone antibiotic treatment in the setting of periprosthetic infection...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29579025/a-novel-small-animal-model-of-irradiated-implant-based-breast-reconstruction
#16
Kasandra R Dassoulas, Jessica S Wang, Madeline M Stovall, Serena S Lei, Jenna M Thuman, Lisa S Salopek, Patrick S Cottler, Angela Pineros-Fernandez, Taeho Kim, CheukKai B Hui, Anthony Archual, Kant Y Lin
PURPOSE: There is currently a need for a clinically relevant small animal model for irradiated, implant based breast reconstruction. Present models are inadequate in terms of suboptimal location of expander placement and mode of radiation delivery, correlating poorly with the human clinical scenario. We hypothesized that by delivering fractionated radiation and placing an expander under the scalp of the animal, we would achieve histologically analogous soft tissue changes seen in human irradiated, implant based breast reconstruction...
March 19, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29570895/repeatability-reproducibility-and-accuracy-of-quantitative-mri-of-the-breast-in-the-community-radiology-setting
#17
Anna G Sorace, Chengyue Wu, Stephanie L Barnes, Angela M Jarrett, Sarah Avery, Debra Patt, Boone Goodgame, Jeffery J Luci, Hakmook Kang, Richard G Abramson, Thomas E Yankeelov, John Virostko
BACKGROUND: Quantitative diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) have the potential to impact patient care by providing noninvasive biological information in breast cancer. PURPOSE/HYPOTHESIS: To quantify the repeatability, reproducibility, and accuracy of apparent diffusion coefficient (ADC) and T1 -mapping of the breast in community radiology practices. STUDY TYPE: Prospective. SUBJECTS/PHANTOM: Ice-water DW-MRI and T1 gel phantoms were used to assess accuracy...
March 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29564032/postmastectomy-breast-reconstruction-with-the-totally-autologous-latissimus-dorsi-flap-in-the-thin-small-breasted-woman-give-it-more-thought
#18
Fawz Kazzazi, Rosanna C Ching, Charles M Malata
Introduction: Thin women have fewer autologous tissue breast reconstructive options than their higher body mass index counterparts-due to a lack of adequate donor sites. They are therefore usually offered expander/implant techniques. The total autologous latissimus dorsi flap is generally used in "well-padded" individuals, as they have enough fat on their back on which a completely autologous reconstruction could be based. When implant-based reconstruction is contraindicated (for instance due to planned adjuvant radiotherapy) or unacceptable to the patient, the total autologous latissimus dorsi flap can provide adequate tissue volume by utilizing the additional back fat deposits even in the thin, small-breasted patient...
2018: Eplasty
https://www.readbyqxmd.com/read/29556759/from-the-fat-capsule-to-the-fat-belt-limiting-protective-lipofilling-on-irradiated-expanders-for-breast-reconstruction-to-selective-key-areas
#19
Nicola Vaia, Federico Lo Torto, Marco Marcasciano, Donato Casella, Claudia Cacace, Carlo De Masi, Fabio Ricci, Diego Ribuffo
BACKGROUND: The number of patients undergoing mastectomy and immediate breast reconstruction with tissue expanders followed by post-mastectomy radiotherapy (PMRT) is exponentially increasing. To reduce the rate of complications, in 2011, the senior author of this manuscript described the use of protective lipofilling in patients undergoing unplanned PMRT to the expander with a specific protocol aiming to decrease the rate of complications. OBJECTIVES: A study was performed to evaluate the thickness of the breast irradiated tissue to create a standard pattern of "protective" lipofilling infiltration on limited key areas that could re-establish a thickness similar to non-radiotreated tissues...
March 19, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29553980/analysis-of-aesthetic-outcomes-and-patient-satisfaction-after-delayed-immediate-autologous-breast-reconstruction
#20
Eva A Huis ʼt Veld, Chao Long, Gloria R Sue, Arhana Chattopadhyay, Gordon K Lee
BACKGROUND: Patients with breast cancer frequently opt to undergo breast reconstruction after mastectomy. The timing and aesthetic outcome of the breast reconstruction may be affected by the need for radiation therapy (RT). Delayed-immediate autologous reconstruction (DIAR) is a novel surgical approach for patients in whom the need for adjuvant RT after mastectomy is preoperatively unknown. AIM: We sought to evaluate the difference in clinical outcomes, patient satisfaction, and cosmetic results between DIAR and patients who underwent delayed autologous reconstruction...
March 16, 2018: Annals of Plastic Surgery
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