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Tissue expander breast

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https://www.readbyqxmd.com/read/29240640/indocyanine-green-angiography-use-in-breast-reconstruction-a-national-analysis-of-outcomes-and-cost-in-110-320-patients
#1
Anmol Chattha, Alexandra Bucknor, Austin D Chen, Bernard T Lee, Samuel J Lin
BACKGROUND: Indocyanine Green (ICG) angiography has gained popularity in breast reconstruction due to its ability to assess the viability of both mastectomy skin and tissue flaps. We aim to analyze trends and outcomes associated with the use of ICG angiography in breast reconstruction. METHODS: Using 2012-2014 data from the Healthcare Cost and Utilization Project National Inpatient Sample, Agency for Healthcare Research and Quality, we identified breast reconstructions that were performed with or without the use of ICG angiography...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29240639/absorbable-antibiotic-beads-prophylaxis-in-immediate-breast-reconstruction
#2
Denise M Kenna, Busayo Irojah, Kimber Lee Mudge, Kendra Eveler
BACKGROUND: Breast reconstruction with tissue expander is the most common mode of reconstruction following mastectomy. Infection necessitating tissue expander removal is a significant complication leading to patient distress as well as increased health care costs. METHODS: Over 3 years, 127 breast reconstructions with tissue expanders were performed by a single surgeon. Fifty-nine of these reconstructions were performed using a standardized protocol in which patients washed with chlorhexidine several days prior to surgery and received intravenous antibiotics preoperatively...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29233522/subcutaneous-implant-based-breast-reconstruction-a-modern-challenge-in-postmastectomy-radiation-planning
#3
Melissa P Mitchell, Jamie Wagner, James Butterworth
PURPOSE: A growing trend in breast reconstruction has been placement of tissue expanders in the pre pectoral space. This is a change from the practice of placement under the pectoralis major with or without an acellular dermal matrix (ADM) sling. The move toward pre pectoral placement with an ADM wrap has the intent of decreasing post-operative pain and decreasing animation deformities. The cosmesis of pre pectoral reconstructions in the setting of post mastectomy radiation has also appeared improved in our early experience, when compared to submuscular reconstructions...
September 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29213346/safe-plastic-surgery-of-the-breast-ii-saving-nipple-sensation
#4
Steven Schulz, Matthew R Zeiderman, J Stephen Gunn, Charles A Riccio, Saeed Chowdhry, Ronald Brooks, Joshua H Choo, Bradon J Wilhelmi
Background: Since its inception, reduction mammoplasty has matured considerably. Primary evolution in clinical research and practice initially focused on developing techniques to preserve tissue viability; breast parenchyma, skin, and nipple tissue that has expanded to include sensation and erectile function play a large role in the physical intimacy of women. Studies regarding primary innervation to the nipple are few and often contradictory. Our past anatomical study demonstrated that primary innervation to the nipple to come from the lateral branch of the fourth intercostal nerve...
2017: Eplasty
https://www.readbyqxmd.com/read/29208440/radiotherapy-in-the-setting-of-breast-reconstruction-types-techniques-and-timing
#5
REVIEW
Alice Y Ho, Zishuo I Hu, Babak J Mehrara, Edwin G Wilkins
As the use of breast reconstruction and postmastectomy radiotherapy (PMRT) has increased over the past decade, the typical approach to integrating radiotherapy with breast reconstruction has provoked intense controversy in the management of breast cancer. PMRT can lead to an increased frequency of complications in the reconstructed breast. Conversely, the reconstructed breast can increase the complexity of radiotherapy delivery. How to minimise the frequency of complications without compromising oncological or cosmetic outcomes of the reconstructed breast is an important shared multidisciplinary goal for oncologists and their patients...
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29190764/selenium-requirements-based-on-muscle-and-kidney-selenoprotein-enzyme-activity-and-transcript-expression-in-the-turkey-poult-meleagris-gallopavo
#6
Rachel M Taylor, Roger A Sunde
The current NRC selenium (Se) requirement for turkeys is 0.2 μg Se/g diet. We previously fed turkey poults a Se-deficient diet (0.005 μg Se/g) supplemented with 10 graded levels of Se (0, 0.025, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.75, 1.0 μg Se/g as Na2SeO3, 5/treatment) for 4 wk, and found that the minimum dietary Se requirement was 0.3 μg Se/g based on selenoprotein enzyme activity in blood, liver, gizzard and pancreas. Because the turkey is primarily a production animal, we expanded this analysis to kidney, heart, breast and thigh...
2017: PloS One
https://www.readbyqxmd.com/read/29184743/infectious-complications-following-breast-reconstruction-using-tissue-expanders-in-patients-with-atopic-dermatitis
#7
Mifue Taminato, Koichi Tomita, Kenji Yano, Ko Hosokawa
Infectious complications represent one of the most prominent factors contributing to tissue expander (TE) loss in breast reconstruction procedures. Several patient characteristics that increase the risk for surgical-site infection or TE infection have been reported, but no study has focused on the relationship between atopic dermatitis (AD) and TE infection or surgical-site infection. Recently, we investigated 203 cases of breast reconstruction surgeries performed using TEs and noted that all 3 patients who had AD developed infectious complications that ultimately led to TE removal...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29184742/a-breast-reconstruction-using-a-breast-prosthesis-and-capsular-flap-for-a-lymphocele-patient
#8
Tomoyuki Yano, Daisuke Shimizu, Yoshitaka Ishii, Osamu Ito, Masayuki Sawaizumi
We encountered a very rare condition where the patient had a lymphocele under the skin envelope of the breast following mastectomy during the course of breast reconstruction with a tissue expander. The incidence rate of axillary lymphoceles is reported as 2.2-50% in breast cancer patients, but there have been no reports mentioning lymphoceles under the breast skin during the course of breast reconstruction with a prosthesis. The patient had a lymphocele in the lower lateral part of the breast following mastectomy and had multiple cellulitis-like inflammations...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29184728/diep-flap-breast-reconstruction-in-patients-with-breast-ptosis-2-stage-reconstruction-using-3-dimensional-surface-imaging-and-a-printed-mold
#9
Koichi Tomita, Kenji Yano, Mifue Taminato, Michiko Nomori, Ko Hosokawa
Background: Autologous breast reconstruction can be performed for breasts with ptosis to a certain extent, but if patients desire to correct ptosis, mastopexy of the contralateral breast is indicated. However, accurate prediction of post-mastopexy breast shape is difficult to make, and symmetrical breast reconstruction requires certain experience. We have previously reported the use of three-dimensional (3D) imaging and printing technologies in deep inferior epigastric artery perforator (DIEP) flap breast reconstruction...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29180174/formalin-fixed-paraffin-embedded-sample-conditions-for-deep-next-generation-sequencing
#10
Masayuki Nagahashi, Yoshifumi Shimada, Hiroshi Ichikawa, Satoru Nakagawa, Nobuaki Sato, Koji Kaneko, Keiichi Homma, Takashi Kawasaki, Keisuke Kodama, Stephen Lyle, Kazuaki Takabe, Toshifumi Wakai
INTRODUCTION: Precision medicine is only possible in oncology practice if targetable genes in fragmented DNA, such as DNA from formalin-fixed paraffin-embedded (FFPE) samples, can be sequenced using next generation sequencing (NGS). The aim of this study was to examine the quality and quantity of DNA from FFPE cancerous tissue samples from surgically resected and biopsy specimens. METHODS: DNA was extracted from unstained FFPE tissue sections prepared from surgically resected specimens of breast, colorectal and gastric cancer, and biopsy specimens of breast cancer...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29168189/imaging-mass-spectrometry-for-novel-insights-into-contact-allergy%C3%A2-%C3%A2-a-proof-of-concept-study-on-nickel
#11
Per Malmberg, Thomas Guttenberg, Marica B Ericson, Lina Hagvall
BACKGROUND: In spite of extensive regulation to limit exposure, nickel remains the main cause of contact allergy in the general population. More detailed knowledge on the skin uptake of haptens is required. So far, no method exists for the visualization of clinically relevant haptens and their distribution in the skin. OBJECTIVES: To show, in terms of a proof of concept, that imaging mass spectrometry [time of flight secondary ion mass spectrometry (ToF-SIMS)] can be applied for investigation of the penetration and distribution of nickel in human skin...
November 23, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29166348/the-economics-of-prepectoral-breast-reconstruction
#12
REVIEW
Scot Bradley Glasberg
The world of breast reconstruction over the last several years has seen a dramatic shift in focus to discussion and the application of placing tissue expanders and implants back into the prepectoral space. Although this technique failed during the early advent of breast reconstruction, newer technologies such as advances in fat grafting, improved acellular dermal matrices, better methods of assessing breast flap viability, and enhanced implants appear to have set the stage for the resurgence and positive early results seen with this technique...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29166346/options-in-acellular-dermal-matrix-device-assembly
#13
Steven Sigalove
Prepectoral prosthetic breast reconstruction has become increasingly popular during the last several years. Original shortcomings and poor outcomes in the 1970s have been overcome with the use of the bioengineered breast concept-namely, use of improved form stable breast implants, autologous fat grafting, and acellular dermal matrices (ADMs). Careful use of these reconstructive tools combined with improved mastectomy skin flaps has lead to successful early outcomes. Prepectoral breast reconstruction mitigates the animation deformities and muscle tightness previously associated with dual-plane prosthetic breast reconstruction while at the same time producing reproducible and outstanding aesthetic outcomes...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29166344/two-stage-prosthetic-breast-reconstruction-a-comparison-between-prepectoral-and-partial-subpectoral-techniques
#14
COMPARATIVE STUDY
Maurice Y Nahabedian, Costanza Cocilovo
BACKGROUND: Prosthetic breast reconstruction with prepectoral placement may confer clinical advantages compared with subpectoral placement. The purpose of this study was to assess and compare clinical outcomes following 2-stage reconstruction following prepectoral and partial subpectoral placement of tissue expanders and implants. METHODS: A retrospective review of 39 (prepectoral) and 50 (partial subpectoral) patients was completed. Acellular dermal matrix was used in all patients...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29164052/development-of-novel-patient-derived-xenografts-from-breast-cancer-brain-metastases
#15
María J Contreras-Zárate, D Ryan Ormond, Austin E Gillen, Colton Hanna, Nicole L Day, Natalie J Serkova, Britta M Jacobsen, Susan M Edgerton, Ann D Thor, Virginia F Borges, Kevin O Lillehei, Michael W Graner, Peter Kabos, Diana M Cittelly
Brain metastases are an increasing burden among breast cancer patients, particularly for those with HER2(+) and triple negative (TN) subtypes. Mechanistic insight into the pathophysiology of brain metastases and preclinical validation of therapies has relied almost exclusively on intracardiac injection of brain-homing cells derived from highly aggressive TN MDA-MB-231 and HER2(+) BT474 breast cancer cell lines. Yet, these well characterized models are far from representing the tumor heterogeneity observed clinically and, due to their fast progression in vivo, their suitability to validate therapies for established brain metastasis remains limited...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29159005/field-specific-intensity-modulated-proton-therapy-optimization-technique-for-breast-cancer-patients-with-tissue-expanders-containing-metal-ports
#16
Maura Kirk, Gary Freedman, Thorsten Ostrander, Lei Dong
This report aims to propose and present an evaluation of a robust pencil beam scanning proton multi-field optimized treatment planning technique for postmastectomy radiation of breast cancer patients with implanted tissue expanders containing an internal metal port. Field-specific split targets were created for optimization to prevent spots from traveling through the metal port, while providing uniform coverage of the target with the use of a multi-field intensity modulated optimization approach. Two beam angles were strategically selected to provide complementary target coverage and plan robustness...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/29139613/nipple-sparing-mastectomy-as-treatment-for-patients-with-ductal-carcinoma-in%C3%A2-situ-a-10-year-follow-up-study
#17
Víctor Lago, Vincenzo Maisto, Julia Gimenez-Climent, Jose Vila, Carlos Vazquez, Rafael Estevan
The objective was to determine the 10-year oncological safety of nipple-sparing mastectomy (NSM) in patients diagnosed with ductal carcinoma in situ (DCIS). The use of NSM preserves the nipple-areola complex (NAC). As residual fibroglandular breast tissue can remain behind the spared NAC, its use for patient with breast cancer is controversial. The oncologic outcomes and complication rates after performing NSM compared to other techniques are still under debate and a concern when treating patients with breast cancer...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29136407/phospholipase-d-inhibitors-reduce-human-prostate-cancer-cell-proliferation-and-colony-formation
#18
Amanda R Noble, Norman J Maitland, Daniel M Berney, Martin G Rumsby
BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastric, kidney and thyroid carcinomas but its role in prostate cancer (PCa), the major cancer of men in the western world, is unclear. METHODS: PLD1 protein expression in cultured PNT2C2, PNT1A, P4E6, LNCaP, PC3, PC3M, VCaP, 22RV1 cell lines and patient-derived PCa cells was analysed by western blotting...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29136180/bcntb-bioinformatics-the-next-evolutionary-step-in-the-bioinformatics-of-breast-cancer-tissue-banking
#19
Emanuela Gadaleta, Stefano Pirrò, Abu Zafer Dayem Ullah, Jacek Marzec, Claude Chelala
Here, we present an update of Breast Cancer Now Tissue Bank bioinformatics, a rich platform for the sharing, mining, integration and analysis of breast cancer data. Its modalities provide researchers with access to a centralised information gateway from which they can access a network of bioinformatic resources to query findings from publicly available, in-house and experimental data generated using samples supplied from the Breast Cancer Now Tissue Bank. This in silico environment aims to help researchers use breast cancer data to their full potential, irrespective of any bioinformatics barriers...
October 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29135896/vertical-skin-paddle-orientation-for-the-latissimus-dorsi-flap-in-breast-reconstruction-a-modification-to-simultaneously-correct-inferior-pole-constriction-and-improve-projection
#20
Megan Fracol, Michelle Grim, Steven Lanier, Neil A Fine
The latissimus dorsi myocutaneous flap (LDMF) is a reliable and frequently used option to bring vascularized skin and soft tissue to improve the stability and aesthetic result in breast reconstruction. Standard techniques with skin paddle inset in a horizontal or oblique fashion preferentially improve anterior projection (when inset at the mastectomy scar) or lower pole and infra-mammary fold (IMF) constriction (when inset into the IMF). Here, we describe a modification for inset of the LDMF that improves both anterior projection and lower pole/IMF constriction, while also allowing the latissimus muscle to fan out and provide complete implant coverage...
November 8, 2017: Plastic and Reconstructive Surgery
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