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https://www.readbyqxmd.com/read/29456260/rf-safety-evaluation-of-a-breast-tissue-expander-device-for-mri-numerical-simulation-and-experiment
#1
Bu S Park, Amir Razjouyan, Leonardo M Angelone, Brent McCright, Sunder S Rajan
This study describes the MRI-related radio frequency (RF) safety evaluation of breast tissue expander devices to establish safety criteria. Numerical simulations and experimental measurements were performed at 64 MHz with a gel phantom containing a breast expander. Additionally, computational modeling was performed (64 and 128 MHz) with an adult female model, containing a virtually implanted breast tissue expander device for four imaging landmark positions. The presence of the breast tissue expander device led to significant alterations in specific absorption rate (SAR) and|B1 + |distributions...
October 2017: IEEE Transactions on Electromagnetic Compatibility
https://www.readbyqxmd.com/read/29443834/does-2-stage-implant-based-breast-reconstruction-allow-for-a-larger-volume-of-the-definite-implant-compared-with-1-stage-reconstruction
#2
R C Killaars, J Hommes, R R van der Hulst, H J Tielemans, V L Negenborn, A Piatkowski
INTRODUCTION: Breast reconstruction using implants is still the main breast reconstruction technique worldwide. Current debate within implant-based breast reconstruction is whether to perform a 1-stage (direct implant) or 2-stage (tissue expander/implant) reconstruction. Volume differences between a woman's native breast and changes in volume after breast reconstruction might be an important factor for a patient's choice between these types of reconstruction. Three-dimensional imaging facilitates objective breast volume estimates...
February 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29422254/the-assisi-think-tank-meeting-and-survey-of-post-mastectomy-radiation-therapy-after-breast-reconstruction-the-attm-smart-report
#3
Cynthia Aristei, Orit Kaidar-Person, Luca Tagliaferri, Meritxell Arenas, Charlotte E Coles, Birgitte V Offersen, Giovanni Frezza, Maria Cristina Leonardi, Vincenzo Valentini, Céline Bourgier, Philip M P Poortmans
PURPOSE: To describe the current European practise on post-mastectomy radiation therapy (PMRT) in relation to breast reconstruction. METHODS: A 21-item questionnaire was distributed online via Survey Monkey. Items referred to 1. general topics (country, centre, years of experience in breast cancer); 2. clinical decision making; 3. RT techniques and dosimetry; 4. dose fractionation. RESULTS: 283 responses were received from 19 countries. Most responders worked in public health services and in academic institutions and had 5-20 years experience...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29401132/defining-infection-in-breast-reconstruction-a-literature-review
#4
Vitali Azouz, Shayda Mirhaidari, Douglas S Wagner
PURPOSE: Postoperative infection is the most common complications after implant-based immediate breast reconstruction (IBR), with reported rates ranging from less than 1% to 43%. This heterogeneity among the literature may be explained by a lack of consensus on the definition of postoperative infection. The purpose of this study was to review the prevalence of infection and how it is defined in studies involving prosthetic-based IBR. It is necessary to establish a clear definition of infection to standardize the reporting of complications...
February 2, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29398609/the-use-of-seri%C3%A2-surgical-scaffolds-in-direct-to-implant-reconstruction-after-skin-sparing-mastectomy-a-retrospective-study-on-surgical-outcomes-and-a-systematic-review-of-current-literature
#5
Arjen A W M van Turnhout, Charlotte J J Franke, Eline J C Vriens-Nieuwenhuis, Wouter B van der Sluis
INTRODUCTION: Little is reported on surgical outcomes of SERI Surgical Scaffold, a bioresorbable silk-derived surgical scaffold, developed to provide soft-tissue support and repair, in implant/expander breast reconstruction. METHODS: A retrospective chart study was conducted of all patients who underwent direct-to-implant reconstruction with a SERI surgical scaffold after skin-sparing mastectomy, recording surgical characteristics, perioperative complications and reoperations...
February 1, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29389701/evaluation-of-modifications-to-tissue-expander-breast-reconstruction-a-quality-improvement-assessment-within-a-private-practice
#6
Henry Wilson, Adam Varnadore
BACKGROUND: As technology advances, surgical practice evolves over time. The author assesses a new approach to implant-based breast reconstruction and the impact of two changes implemented over several years. METHODS: A series of tissue-expander reconstructions performed early in the author's experience were retrospectively compared with a similar number of cases prospectively performed. Demographics, perioperative characteristics, and postoperative outcomes were assessed...
January 31, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29384865/postoperative-outcomes-of-breast-reconstruction-after-mastectomy-a-retrospective-study
#7
Qinghong Qin, Qixing Tan, Bin Lian, Qinguo Mo, Zhen Huang, Changyuan Wei
Breast reconstruction after mastectomy plays an active role in improving the quality-of-life (QoL) and alleviating the psychological trauma of breast cancer patients, and has become an indispensable part of the comprehensive treatment in breast cancer. However, compared with mastectomy alone, breast reconstruction also increase operative complications. The surgical, oncological outcomes, and cosmetic effect of breast reconstruction remains to be evaluated. Data for patients with breast cancer who underwent breast reconstruction after mastectomy from February 2009 to November 2015 in our hospital were retrospectively analyzed, with a median follow-up time of 44 months...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383121/targeting-the-sumo-pathway-as-a-novel-treatment-for-anaplastic-thyroid-cancer
#8
James P De Andrade, Allison W Lorenzen, Vincent T Wu, Maria V Bogachek, Jung M Park, Vivian W Gu, Claire M Sevenich, Victoria C Cassady, Anna C Beck, Mikhail V Kulak, Robert A Robinson, Geeta Lal, Ronald J Weigel
Cancer stem cells (CSCs) are expanded in anaplastic thyroid cancer (ATC) and standard treatment approaches have failed to improve survival, suggesting a need to specifically target the CSC population. Recent studies in breast and colorectal cancer demonstrated that inhibition of the SUMO pathway repressed CD44 and cleared the CSC population, mediated through SUMO-unconjugated TFAP2A. We sought to evaluate effects of inhibiting the SUMO pathway in ATC. ATC cell lines and primary ATC tumor samples were evaluated...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29371915/expansion-of-tumor-infiltrating-lymphocytes-and-their-potential-for-application-as-adoptive-cell-transfer-therapy-in-human-breast-cancer
#9
Hee Jin Lee, Young-Ae Kim, Chan Kyu Sim, Sun-Hee Heo, In Hye Song, Hye Seon Park, Suk Young Park, Won Seon Bang, In Ah Park, Miseon Lee, Jung Hoon Lee, Yeon Sook Cho, Suhwan Chang, Jaeyun Jung, Jisun Kim, Sae Byul Lee, Sung Youl Kim, Myeong Sup Lee, Gyungyub Gong
Adoptive cell transfer (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs) has been successful in treating a considerable proportion of patients with metastatic melanoma. In addition, some patients with several other solid tumors were recently reported to have benefited clinically from such ACT. However, it remains unclear whether ACT using TILs is broadly applicable in breast cancer, the most common cancer in women. In this study, the utility of TILs as an ACT source in breast cancers was explored by deriving TILs from a large number of breast cancer samples and assessing their biological potentials...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29369976/direct-to-implant-breast-reconstruction-in-women-older-than-65-years-a-retrospective-analysis-of-complication-rate-and-overall-outcomes
#10
Rebecca Knackstedt, James Gatherwright, Andrea Moreira
BACKGROUND: Half of all cancers occur in women older than 65 years, yet only 4 to 14 percent of these women undergo reconstruction. Most studies on reconstruction in the elderly have focused on tissue expander/implant or autologous reconstruction. A direct-to-implant approach theoretically reduces the number of operations and postoperative visits, but has yet to be investigated in the elderly. METHODS: Institutional review board approval was granted for a retrospective chart review for patients who underwent direct-to-implant reconstruction from 2012 to 2015 with any staff in the authors' department...
February 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29369110/moffitt-cancer-center-experience-of-tissue-expander-breast-reconstruction-does-acellular-dermal-matrix-increase-return-to-the-operating-room
#11
Brielle Weinstein, Ambuj Kumar, Paul Smith, Deniz Dayicioglu
BACKGROUND: Tissue expander and implant remains the most common technique for breast reconstruction. A controversial topic within this method is routine use of acellular dermal matrix (ADM). Acellular dermal matrices have increased risks of infection, seroma, hematoma, skin flap necrosis, and total complications. METHODS: After an institutional review board approval, a retrospective chart review was conducted of 756 tissue expander with implant cases from November 2010 to November 2016 at Moffitt Cancer Center with 2 breast reconstruction surgeons...
January 24, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29368031/efficacy-of-partial-versus-full-sling-acellular-dermal-matrix-use-in-implant-based-breast-reconstruction-a-head-to-head-comparison
#12
Kyeong-Tae Lee, Yeseul Eom, Goo-Hyun Mun, Sa Ik Bang, Byung-Joon Jeon, Jai-Kyong Pyon
BACKGROUND: Acellular dermal matrix (ADM), popularly used in tissue expander-based breast reconstruction, is applied either as a partial or full sling, but without any consensus regarding which method of application produces better outcomes. We aimed to compare the outcomes between two patient groups who underwent tissue expander-based breast reconstruction using these techniques. METHODS: A retrospective review was conducted for consecutive patients who underwent immediate two-stage implant-based breast reconstruction using ADM between January 2013 and June 2016...
January 24, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29360922/salvage-of-implant-based-breast-reconstruction-in-nipple-sparing-mastectomies-with-autologous-flaps
#13
Ali A Qureshi, Jeremie D Oliver, Rajiv P Parikh, Marissa M Tenenbaum, Terence M Myckatyn
Background: Implant-based breast reconstruction (IBR) after nipple-sparing mastectomies (NSM) can have complications that require explantation of a tissue expander or permanent prosthesis. When complications occur, preservation of the nipple-areola complex (NAC) remains critical to ensure aesthetic breast reconstruction. To date, there are minimal data on outcomes for patients experiencing unplanned explantations in IBR after NSM. Objectives: To evaluate final reconstructive outcomes for NSM patients who undergo IBR and have an unplanned explanation and to separately analyze the outcome of the NAC aesthetic subunit...
January 18, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29342302/determination-of-the-appropriate-physical-density-of-internal-metallic-ports-in-temporary-tissue-expanders-for-the-treatment-planning-of-post-mastectomy-radiation-therapy
#14
Norifumi Mizuno, Haruna Takahashi, Jiro Kawamori, Naoki Nakamura, Mami Ogita, Shogo Hatanaka, Ryouhei Yamauchi, Masatsugu Hariu, Kenji Sekiguchi
Some patients undergoing breast reconstruction require post-mastectomy radiation therapy, but the metallic ports used in temporary tissue expanders attenuate the X-rays. In this study, we evaluated by the film method, the attenuation of 4 MV and 6 MV X-rays after passing through a metallic port, with the aim of identifying a useful method for determining the appropriate density to use in the radiation treatment planning system (RTPS), taking into account the distance between the metallic port and the targets...
January 12, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29341112/conditionally-reprogrammed-cells-crc-methodology-does-not-allow-the-in-vitro-expansion-of-patient-derived-primary-and-metastatic-lung-cancer-cells
#15
Giovanni Sette, Valentina Salvati, Ilenia Giordani, Emanuela Pilozzi, Denise Quacquarini, Enrico Duranti, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Mario Falchi, Roberto Pallini, Ruggero De Maria, Adriana Eramo
Availability of tumor and non-tumor patient-derived models would promote the development of more effective therapeutics for non-small cell lung cancer (NSCLC). Recently, conditionally reprogrammed cells (CRC) methodology demonstrated exceptional potential for the expansion of epithelial cells from patient tissues. However, the possibility to expand patient-derived lung cancer cells using CRC protocols is controversial. Here, we used CRC approach to expand cells from non-tumoral and tumor biopsies of patients with primary or metastatic NSCLC as well as pulmonary metastases of colorectal or breast cancers...
January 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29334788/latissimus-dorsi-flap-in-breast-reconstruction-recent-innovations-in-the-workhorse-flap
#16
Rachita Sood, Jeena M Easow, Geoffrey Konopka, Zubin J Panthaki
BACKGROUND: Surgeons employ the latissimus dorsi flap (LDF) for reconstruction of a large variety of breast cancer surgery defects, including quadrantectomy, lumpectomy, modified radical mastectomy, and others. The LDF may be used in delayed or immediate reconstruction, in combination with tissue expanders for a staged reconstruction, with implant-based immediate reconstruction, or alone as an autogenous flap. METHODS: The authors discuss the historical uses and more recent developments in the LDF...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29325422/outcomes-in-deep-inferior-epigastric-perforator-flap-and-implant-based-reconstruction-does-age-really-matter
#17
Lauren V Kuykendall, Angie Zhang, Bugra Tugertimur, Sara Bijan, Corin Agoris, Ambuj Kumar, Deniz Dayicioglu
Despite the growing elderly population, there is limited research specific to this demographic concerning breast reconstruction (BR). Lack of evidence-based BR recommendations in older populations may contribute to misconceptions and subsequent underutilization of BR, especially autologous BR. Patients who received either deep inferior epigastric perforator (DIEP) flap BR or tissue expander/implant (TE/I) BR by a single surgeon between July 2011 and July 2015 were surveyed postoperatively by using the psychometrically validated BREAST-Q questionnaire to determine patient satisfaction...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29320921/benefits-and-risks-with-acellular-dermal-matrix-adm-and-mesh-support-in-immediate-breast-reconstruction-a-systematic-review-and-meta-analysis
#18
Håkan Hallberg, Svanheidur Rafnsdottir, Gennaro Selvaggi, Annika Strandell, Ola Samuelsson, Ida Stadig, Therese Svanberg, Emma Hansson, Richard Lewin
In modern implant-based immediate breast reconstruction, it has become common to use biological acellular dermal and synthetic matrices in combination with a tissue expander or an implant. The aim of this systematic review was to examine differences in recurrence of cancer, impact on oncological treatment, health related quality of life, complications and aesthetic outcome between matrix and no matrix in immediate breast reconstruction. Systematic searches, data extraction and assessment of methodological quality were performed according to predetermined criteria...
January 10, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29316048/does-response-to-neo-adjuvant-chemotherapy-impact-breast-reconstruction
#19
Michael R Cassidy, Emily C Zabor, Michelle Stempel, Babak Mehrara, Mary L Gemignani
Neo-adjuvant chemotherapy (NAC) is administered in breast cancer treatment for downstaging of disease. Here, we determined the impact of response to NAC on breast reconstruction uptake. A prospective NAC and mastectomy database with or without reconstruction were reviewed with IRB approval. Univariable analyses were conducted using Kruskal-Wallis or Fisher's exact tests. Multivariable logistic regression was used to adjust for potential confounders. We identified 271 patients with unilateral breast cancer receiving NAC and either unilateral or bilateral mastectomy from 9/2013 to 5/2016...
January 8, 2018: Breast Journal
https://www.readbyqxmd.com/read/29302496/selective-pectoralis-major-muscle-denervation-in-breast-reconstruction-a-technical-modification-for-more-effective-and-cosmetic-results
#20
Marco Bernini, Donato Casella, Carlo Mariotti
The use of pectoralis major muscle (PMM) in breast reconstruction has been a mainstay for decades. In recent years, although, a novel approach, the so-called subcutaneous or pre-pectoral breast reconstruction, has been introduced advocating the advantages of sparing the pectoralis muscle. Such advantages include more natural implant ptosis and appearance, significant reduction of capsular contracture and also avoidance of implant animation and animation deformities. These are all drawbacks that the use of muscles in implant coverage inevitably involves overtime...
December 2017: Gland Surgery
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