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https://www.readbyqxmd.com/read/27919946/in-vivo-selection-of-intermediately-and-highly-malignant-variants-of-triple-negative-breast-cancer-in-orthotopic-nude-mouse-models
#1
Shuya Yano, Kiyoto Takehara, Hiroyuki Kishimoto, Hiroshi Tazawa, Yasuo Urata, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman
AIM: Triple-negative breast cancer (TNBC), defined by the absence of receptors for estrogen, progesterone and human epithelial receptor 2 (HER2), is a recalcitrant disease in need of effective therapy. We previously isolated very-highly metastatic variants of the TNBC cell line MDA-MB-231 using serial orthotopic implantation of MDA-MB-231 human breast cancer cells in nude mice. MATERIALS AND METHODS: MDA-MB-231 cells expressing red fluorescent protein (MDA-MB-231-RFP) (1×10(7) cells/site) were initially injected subcutaneously in the flank of nude mice...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27911269/the-matricellular-protein-cyr61-promotes-breast-cancer-lung-metastasis-by-facilitating-tumor-cell-extravasation-and-suppressing-anoikis
#2
Yu-Ting Huang, Qiang Lan, Girieca Lorusso, Nathalie Duffey, Curzio Rüegg
Matricellular proteins play multiple roles in primary tumor growth, local invasion and tumor angiogenesis. However, their contribution to metastasis and the putative mechanisms involved are less well characterized. In ER-negative human breast cancer, elevated expression levels of the matricellular protein Cysteine-rich angiogenic inducer 61 (CYR61) are associated with more aggressive progression. Here, we investigated the role of CYR61 in breast cancer lung metastasis using the triple negative human breast cancer cell lines MDA-MB-231 and SUM159...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27889857/accurate-control-of-17%C3%AE-estradiol-long-term-release-increases-reliability-and-reproducibility-of-preclinical-animal-studies
#3
Céline Gérard, Anne Gallez, Charline Dubois, Pierre Drion, Philippe Delahaut, Etienne Quertemont, Agnès Noël, Christel Pequeux
Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to-use slow releasing devices to administer steroids, especially estrogens, to small experimental animals remains the method of choice in terms of animal well-being and of safety for both the researcher and the animal. In this study, we evaluated and compared, in vitro and in vivo, the release kinetic of estradiol (E2) over sixty days from two different slow-releasing systems: the matrix pellet (MP) and the reservoir implant (RI)...
November 26, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27884590/physical-activity-induced-protection-against-breast-cancer-risk-associated-with-delayed-parity
#4
Kathleen M Sturgeon, Aaron Schweitzer, John J Leonard, Deirdre K Tobias, Ying Liu, Elizabeth Cespedes Feliciano, Vasanti S Malik, Amit Joshi, Bernard Rosner, Bart C De Jonghe
Epidemiological evidence indicates that physical activity between menarche and first pregnancy is associated with a lower risk of breast cancer among women with at least 20years between these reproductive events. The mechanism by which physical activity during this interval confers protection is unknown. This study used a novel animal model to assess potentially protective effects of physical activity on tumor development in delayed parity. Thirty-six female Sprague Dawley rats received an i.p. injection of 50mg/kg N-methyl-N-nitrosourea (MNU) at 5weeks of age...
November 21, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27863373/tumor-targeting-adenovirus-obp-401-inhibits-primary-and-metastatic-tumor-growth-of-triple-negative-breast-cancer-in-orthotopic-nude-mouse-models
#5
Shuya Yano, Kiyoto Takehara, Hiroyuki Kishimoto, Hiroshi Tazawa, Yasuo Urata, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman
Our laboratory previously developed a highly-invasive, triple-negative breast cancer (TNBC) variant using serial orthotopic implantation of the human MDA-MB-231 cell line in nude mice. The isolated variant was highly-invasive in the mammary gland and lymphatic channels and metastasized to lymph nodes in 10 of 12 mice compared to 2 of 12 of the parental cell line. In the present study, the tumor-selective telomerase dependent OBP-401 adenovirus was injected intratumorally (i.t.) (1 × 108 PFU) when the high-metastatic MDA-MB-231 primary tumor expressing red fluorescent protein (MDA-MB-231-RFP) reached approximately 500 mm3 (diameter; 10 mm)...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27826457/distant-migration-of-multiple-siliconomas-in-lower-extremities-following-breast-implant-rupture-case-report
#6
Joo Hyun Oh, Seung Yong Song, Dae Hyun Lew, Dong Won Lee
Siliconoma from ruptured breast implants has been reported in multiple body sites, including but not limited to the breast parenchyma, axillary lymph nodes, upper arm, and even lower leg. In this regard, we report a rare case of distant silicone migration to the lower extremities after traumatic breast implant rupture. A 55-year-old Asian woman who received bilateral augmentation mammoplasty 20 years ago presented with ruptured breast implants from a car accident 2 years earlier. Magnetic resonance imaging confirmed intracapsular and extracapsular rupture of the right breast implant, showing "linguine sign...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27773734/liposomal-prednisolone-inhibits-tumor-growth-in-a-spontaneous-mouse-mammary-carcinoma-model
#7
Anil K Deshantri, Sander A A Kooijmans, Sylvia A Kuijpers, Maria Coimbra, Astrid Hoeppener, Gert Storm, Marcel H A M Fens, Raymond M Schiffelers
Cancers are abundantly infiltrated by inflammatory cells that are modulated by tumor cells to secrete mediators fostering tumor cell survival and proliferation. Therefore, agents that interfere with inflammatory signaling molecules or specific immune cell populations have been investigated as anticancer drugs. Corticosteroids are highly potent anti-inflammatory drugs, whose activity is intensified when targeted by nanocarrier systems. Liposome-targeted corticosteroids have been shown to inhibit tumor growth in different syngeneic murine tumor models as well as human xenograft mouse models, which is attributed to a switch in the tumor microenvironment from a pro-inflammatory to an anti-inflammatory state...
October 20, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27766402/management-of-implant-exposure-in-one-stage-breast-reconstruction-using-titanium-coated-polypropylene-mesh-sub-mammary-intercostal-perforator-flap
#8
Michele Antonio De Riggi, Nicola Rocco, Giulio Gherardini, Emanuela Esposito, Massimiliano D'Aiuto
INTRODUCTION: One-stage implant-based breast reconstruction using titanium-coated polypropylene mesh is a novel approach widely used in Europe. Complication rates in breast reconstruction with the use of titanium-coated meshes seem to be comparable to those in patients with implant-based breast reconstruction alone. However, the use of synthetic meshes in implant-based breast reconstructive surgery leads to new clinical scenarios with the need for the breast surgeon to face new complications...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27727088/cardiac-surgery-or-interventional-cardiology-why-not-both-let-s-go-hybrid
#9
Nikolaos A Papakonstantinou, Nikolaos G Baikoussis, Panagiotis Dedeilias, Michalis Argiriou, Christos Charitos
A hybrid strategy, firstly performed in the 1990s, is a combination of tools available only in the catheterization laboratory with those available only in the operating room in order to minimize surgical morbidity and face with any cardiovascular lesion. The continuous evolution of stent technology along with the adoption of minimally invasive surgical approaches, make hybrid approaches an attractive alternative to standard surgical or transcatheter techniques for any given set of cardiovascular lesions. Examples include hybrid coronary revascularization, when an open surgical anastomosis of the left internal mammary artery to the left anterior descending coronary artery is performed along with stent implantation in non-left anterior descending coronary vessels, open heart valve surgery combined with percutaneous coronary interventions to coronary lesions, hybrid aortic arch debranching combined with endovascular grafting for thoracic aortic aneurysms, hybrid endocardial and epicardial atrial fibrillation procedures, and carotid artery stenting along with coronary artery bypass grafting...
October 8, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27722056/life-threatening-cardiac-episode-in-a-polish-patient-carrying-contiguous-gene-microdeletion-of-the-tbx5-and-the-tbx3-genes
#10
Katarzyna Iwanicka-Pronicka, Magdalena Socha, Maria Jędrzejowska, Małgorzata Krajewska-Walasek, Aleksander Jamsheer
Holt-Oram syndrome (HOS) features radial ray hypoplasia, heart defect and cardiac conduction impairment. Ulnar-mammary syndrome (UMS) characterizes congenital defects of the ulnar side of the upper limbs, underdevelopment of apocrine glands including hypoplasia and the dysfunction of mammary glands, hypogonadism and obesity. Inheritance of both conditions is autosomal dominant, mutations or deletions are found in the TBX5 and TBX3 gene, respectively. The Polish patient presented short stature, obesity, congenital malformation of the radial and ulnar side of the upper limbs, heart block, hypogonadism and dysmorphic features...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27716382/gender-differences-in-outcomes-following-isolated-coronary-artery-bypass-grafting-long-term-results
#11
Francesco Nicolini, Antonella Vezzani, Daniela Fortuna, Giovanni Andrea Contini, Davide Pacini, Davide Gabbieri, Claudio Zussa, Rossana De Palma, Tiziano Gherli
BACKGROUND: The main purpose of this study was to evaluate the impact of gender on outcomes after isolated coronary artery bypass grafting, in terms of 5-year rates of overall death, cardiac-related death, myocardial infarction, re-hospitalization, repeat percutaneous or surgical revascularization, stroke, new pacemaker implantation, postoperative renal failure, heart failure and need for long-term care. METHODS: Two propensity-score matched cohorts, each of 1331 patients, undergoing isolated surgical coronary revascularization at the regional public and private centers of Emilia-Romagna region (Italy) from January 1st 2003 to December 31th 2013, were used to compare long-term outcomes of male (5976 patients) versus female gender (1332 patients)...
September 30, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27676678/evaluation-of-bone-cancer-pain-induced-by-different-doses-of-walker-256-mammary-gland-carcinoma-cells
#12
Changsheng Dong, RuiXin Wu, Jing Wu, Jing Guo, Fangyuan Wang, Yanli Fu, Qing Wang, Ling Xu, Juyong Wang
BACKGROUND: Cancer pain is a complex medical syndrome. Understanding its underlying mechanisms relies on the use of animal models which can mimic the human condition. A crucial component of this model is the quantity of tumor cells; however, the exact relationship between the doses of tumor cells on bone cancer pain is yet unknown. OBJECTIVE: We explored the relationship of different doses of Walker 256 carcinoma cells using a bone cancer pain model in rats, and evaluated its success and stability...
September 2016: Pain Physician
https://www.readbyqxmd.com/read/27635043/enhanced-survival-with-implantable-scaffolds-that-capture-metastatic-breast-cancer-cells-in-vivo
#13
Shreyas S Rao, Grace G Bushnell, Samira M Azarin, Graham Spicer, Brian A Aguado, Jenna R Stoehr, Eric J Jiang, Vadim Backman, Lonnie D Shea, Jacqueline S Jeruss
The onset of distant organ metastasis from primary breast cancer marks the transition to a stage IV diagnosis. Standard imaging modalities often detect distant metastasis when the burden of disease is high, underscoring the need for improved methods of detection to allow for interventions that would impede disease progression. Here, microporous poly(ε-caprolactone) scaffolds were developed that capture early metastatic cells and thus serve as a sentinel for early detection. These scaffolds were used to characterize the dynamic immune response to the implant spanning the acute and chronic foreign body response...
September 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27627068/capsular-contracture-in-silicone-breast-implants-insights-from-rat-models
#14
Vilberto J Vieira, Armando D'Acampora, Fernanda S Neves, Paulo R Mendes, Zulmar A DE Vasconcellos, Rodrigo D'Eça Neves, Claudia P Figueiredo
Breast augmentation with silicone implants is one of the most common procedures performed by plastic surgeons around the world. Capsular contracture is a frequent complication in breast augmentation and reconstructive surgery, that requires invasive intervention. The inflammatory response to implanted mammary prostheses appears to be directly associated to capsular contracture. This review discusses the evidences from rat models studies, on the role of inflammation and fibrosis in capsular contraction and its relation to silicone breast implants surface...
September 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27626220/enhanced-metastatic-recurrence-via-lymphatic-trafficking-of-a-high-metastatic-variant-of-human-triple-negative-breast-cancer-after-surgical-resection-in-orthotopic-nude-mouse-models
#15
Shuya Yano, Kiyoto Takehara, Hiroshi Tazawa, Hiroyuki Kishimoto, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M Hoffman
We previously developed and characterized a highly invasive and metastatic triple-negative breast cancer (TNBC) variant by serial orthotopic implantation of MDA-MB-231 human breast cancer cells in nude mice. Eventually, a highly invasive and metastatic variant of human TNBC was isolated after lymph node metastases was harvested and orthotopically re-implanted into the mammary gland of nude mice for two cycles. The variant thereby isolated is highly invasive in the mammary gland and metastasized to lymph nodes in 10 of 12 mice compared to 2 of 12 of the parental cell line...
September 14, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27625032/in-vivo-changes-of-breast-perfusion-after-augmentation
#16
Edward Teng, P Niclas Broer, Paul I Heidekrueger, Antonio J Forte, Rachel Lentz, Melissa Durand, Madhavi Raghu, Stephanie L Kwei
BACKGROUND: Revision surgeries after breast augmentation are associated with an increased risk of complications (eg, nipple areolar complex [NAC]) necrosis. Consequently, maintaining perfusion to the NAC is a critical aspect of secondary breast surgery. OBJECTIVES: The purpose of this study was to examine in vivo changes in perfusion to the NAC after implant breast augmentation using magnetic resonance imaging (MRI) technology. METHODS: High-resolution 3 Tesla MRI images of 10 women (20 breasts) with previous breast augmentation were compared to a control population of 15 women (30 breasts)...
September 13, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27600054/glucosamine-and-n-acetyl-glucosamine-as-new-cest-mri-agents-for-molecular-imaging-of-tumors
#17
Michal Rivlin, Gil Navon
The efficacy of glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) as agents for chemical exchange saturation transfer (CEST) magnetic resonance molecular imaging of tumors is demonstrated. Both agents reflect the metabolic activity and malignancy of the tumors. The method was tested in two types of tumors implanted orthotopically in mice: 4T1 (mouse mammary cancer cells) and MCF7 (human mammary cancer cells). 4T1 is a more aggressive type of tumor than MCF7 and exhibited a larger CEST effect. Two methods of administration of the agents, intravenous (IV) and oral (PO), gave similar results...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27581027/modeling-breast-tumor-development-with-a-humanized-mouse-model
#18
Lisa M Arendt
The tumor microenvironment plays a critical role in breast cancer growth and progression to metastasis. Here, we describe a method to examine stromal-epithelial interactions during tumor formation and progression utilizing human-derived mammary epithelial cells and breast stromal cells. This method outlines the isolation of each cell type from reduction mammoplasty tissue, the culture and genetic modification of both epithelial and stromal cells using lentiviral technology, and the method of humanizing and implantation of transformed epithelial cells into the cleared mammary fat pads of immunocompromised mice...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27567946/-correction-of-thoraco-mammary-deformity-of-poland-syndrome
#19
E Delay, S La Marca, S Guerid
Breast deformity of Poland syndrome is a malformation known to be difficult to treat. Numerous descriptions of surgical corrections have been published but none achieved to correct severe cases before description of lipomodeling technique. The aim of this article is to present thoraco-mammary deformity of Poland syndrome, corrections techniques already available and therapeutical indications in primary and secondary cases. Constant anomaly of Poland syndrome is agenesis of sternocostal part of pectoralis major muscle but other muscular anomalies can be associated...
October 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27553115/a-retrospective-comparison-study-of-the-infra-mammary-approach-to-the-standard-mastectomy-scar-in-the-2nd-stage-of-tissue-expander-to-implant-breast-reconstruction
#20
M Karunanayake, E Boghossian, A Govshievich, C Bernier, M A Danino
BACKGROUND: Staged expander-to-implant breast reconstruction is plagued by a high prevalence of complications. We have employed an alternative approach of using the infra-mammary crease (IMF) for expander-to-implant exchange. The IMF approach was thought to utilize healthier tissues, which are believed to be less affected by the process of tissue expansion, and reside distant from the field of the radiotherapy boost. METHODS: A retrospective chart review was performed on all patients undergoing a staged implant-based breast reconstruction from 2009 to 2014...
August 20, 2016: Annales de Chirurgie Plastique et Esthétique
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