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https://www.readbyqxmd.com/read/29164052/development-of-novel-patient-derived-xenografts-from-breast-cancer-brain-metastases
#1
María J Contreras-Zárate, D Ryan Ormond, Austin E Gillen, Colton Hanna, Nicole L Day, Natalie J Serkova, Britta M Jacobsen, Susan M Edgerton, Ann D Thor, Virginia F Borges, Kevin O Lillehei, Michael W Graner, Peter Kabos, Diana M Cittelly
Brain metastases are an increasing burden among breast cancer patients, particularly for those with HER2(+) and triple negative (TN) subtypes. Mechanistic insight into the pathophysiology of brain metastases and preclinical validation of therapies has relied almost exclusively on intracardiac injection of brain-homing cells derived from highly aggressive TN MDA-MB-231 and HER2(+) BT474 breast cancer cell lines. Yet, these well characterized models are far from representing the tumor heterogeneity observed clinically and, due to their fast progression in vivo, their suitability to validate therapies for established brain metastasis remains limited...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29135896/vertical-skin-paddle-orientation-for-the-latissimus-dorsi-flap-in-breast-reconstruction-a-modification-to-simultaneously-correct-inferior-pole-constriction-and-improve-projection
#2
Megan Fracol, Michelle Grim, Steven Lanier, Neil A Fine
The latissimus dorsi myocutaneous flap (LDMF) is a reliable and frequently used option to bring vascularized skin and soft tissue to improve the stability and aesthetic result in breast reconstruction. Standard techniques with skin paddle inset in a horizontal or oblique fashion preferentially improve anterior projection (when inset at the mastectomy scar) or lower pole and infra-mammary fold (IMF) constriction (when inset into the IMF). Here, we describe a modification for inset of the LDMF that improves both anterior projection and lower pole/IMF constriction, while also allowing the latissimus muscle to fan out and provide complete implant coverage...
November 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29079540/il-18-contributes-to-bone-cancer-pain-by-regulating-glia-cells-and-neuron-interaction
#3
Su Liu, Yue-Peng Liu, You Lv, Jun-Li Yao, Dong-Mei Yue, Mao-Yin Zhang, Dun-Yi Qi, Gong-Jian Liu
BACKGROUND: Glia cells hyperactivity has been proposed to be responsible for chronic pain, however, the mechanisms remain unclear. IL-18, released from glial cells, has been reported to be involved in neuropathic pain. Here, we investigated the role of IL-18 in bone cancer pain. METHODS: Bone cancer pain was mimicked by injecting Walker-256 mammary gland carcinoma cells into the intramedullary space of the tibia in rats. Expression and location of IL-18 and IL-18 receptor were tested...
October 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29069320/breast-implant-q-fever-as-a-source-of-in-hospital-transmission
#4
Ayal Hassidim, Hila Elinav, Ayelet Michael-Gayego, Shmuel Benenson, Shlomi Yaalomy, Karen Meir, Uriel Elchalal, Tomer Tzur
Herein, we describe the first case of mammary implant infection caused by Coxiella b urnetii , resulting in delayed diagnosis and treatment and an in-hospital cross transmission of Q-fever to medical personnel.
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29048670/suppression-of-tumor-derived-semaphorin%C3%A2-7a-and-genetic-ablation-of-host-derived-semaphorin%C3%A2-7a-impairs-tumor-progression-in-a-murine-model-of-advanced-breast-carcinoma
#5
R Garcia-Areas, S Libreros, M Simoes, C Castro-Silva, N Gazaniga, S Amat, J Jaczewska, P Keating, K Schilling, M Brito, E P Wojcikiewicz, V Iragavarpu-Charyulu
Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine model of advanced breast carcinoma. We used anti-SEMA7A short hairpin RNA (shRNA) to gene silence SEMA7A in 4T1 mammary tumor cells. When implanted into the mammary fat pads of syngeneic mice, SEMA7A shRNA-expressing 4T1 tumors exhibited decreased growth rates, deferred metastasis and reduced mortality...
October 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29040345/eight-year-safety-data-for-round-and-anatomical-silicone-gel-breast-implants
#6
Franck Duteille, Pierre Perrot, Marie-Hélène Bacheley, Sharon Stewart
Background: The safety and efficacy of all medical devices, including breast implants, is important and consistent performance is best shown by undertaking long-term clinical and vigilance studies. Local complications such as capsular contracture and rupture are risks often associated with breast implant surgery. Objectives: The authors investigate and evaluate the safety and performance of Eurosilicone's (Eurosilicone S.A.S, Apt Cedex, France) Cristalline Paragel breast implants at 8 years postimplantation...
June 24, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28972008/differential-gene-regulation-and-tumor-inhibitory-activities-of-alpha-delta-and-gamma-tocopherols-in-estrogen-mediated-mammary-carcinogenesis
#7
Soumyasri Das Gupta, Misaal Patel, Joseph Wahler, Min Ji Bak, Brian A Wall, Mao-Jung Lee, Yong Lin, Weichung Joe Shih, Li Cai, Chung S Yang, Nanjoo Suh
Despite experimental evidence elucidating the anti-tumor activities of tocopherols, clinical trials with α-tocopherol (α-T) have failed to demonstrate its beneficial effects in cancer prevention. This study compared the chemopreventive efficacy of individual tocopherols (α-, δ-, γ-T) and a γ-T rich tocopherol mixture (γ-TmT) in the August Copenhagen Irish (ACI) rat model of estrogen-mediated mammary cancer. Female ACI rats receiving 17β-estradiol (E2) implants were administered with 0.2% α-T, δ-T, γ-T or γ-TmT for 30 weeks...
September 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28944088/loss-of-the-vitamin-d-receptor-in-human-breast-and-prostate-cancers-strongly-induces-cell-apoptosis-through-downregulation-of-wnt-%C3%AE-catenin-signaling
#8
Yu Zheng, Trupti Trivedi, Ruby Cy Lin, Colette Fong-Yee, Rick Nolte, Jeline Manibo, Yunzhao Chen, Musharraf Hossain, Konstantin Horas, Colin Dunstan, Hong Zhou, Markus J Seibel
Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro...
2017: Bone Research
https://www.readbyqxmd.com/read/28890745/a-simple-and-practical-method-for-setting-up-a-criterion-of-projection-of-silicone-breast-implant-after-simple-mastectomy
#9
Naohiro Ishii, Jiro Ando, Michiko Harao, Masaru Takemae, Kazuo Kishi
Objective: In breast reconstruction, decision of projection of silicone breast implant in tissue expander replacement is difficult because of the need to consider several parameters that cannot be expressed in accurate numerical form. The present study aimed at a quantitative analysis based on decreased projection of the reconstructed side compared with silicone breast implant projection and to develop a new method for simple and practical decision of silicone breast implant projection. Methods: Thirty-five patients who had mammary carcinoma and were treated with simple mastectomy, tissue expander insertion, and replacement with anatomical silicone breast implant from April 2013 to March 2016 were retrospectively identified...
2017: Eplasty
https://www.readbyqxmd.com/read/28870114/alleviating-mechanical-allodynia-and-modulating-cellular-immunity-contribute-to-electroacupuncture-s-dual-effect-on-bone-cancer-pain
#10
Yi Liang, Jun-Ying Du, Jun-Fan Fang, Ruo-Yi Fang, Jie Zhou, Xiao-Mei Shao, Yong-Liang Jiang, Yi-Tian Chen, Jian-Qiao Fang
HYPOTHESIS: Electroacupuncture (EA) has been used as an alternative analgesic therapy for hundreds of years, yet its analgesic potency and therapeutic advantage against bone cancer pain (BCP) in comparison with morphine remains unclear. This study aimed to investigate the effects of EA on mechanical allodynia and cellular immunity of BCP rats, and to further explore the potential mechanism. METHODS: The BCP model was established by implanting Walker 256 mammary gland carcinoma cells into the left tibia of adult female Sprague-Dawley rats...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28862112/indications-of-the-magnetic-resonance-method-in-breast-pathology
#11
Adina Chiriţă
The high incidence of breast cancer is a known fact. The 5-year survival rate for women with correctly treated breast cancer is 90% around the world, and 50% in Romania, respectively. Correct diagnostic evaluation of the breasts allows for a competent therapeutic management. The primary diagnosis of breast cancer includes clinical examination of the breasts, breast ultrasound and mammography. Magnetic resonance imaging (MRI) examination is not a first line type of investigation, but targeted to selected patient groups...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28838284/enhancing-the-radiation-response-of-tumors-but-not-early-or-late-responding-normal-tissues-using-a-vascular-disrupting-agent
#12
Michael R Horsman
INTRODUCTION: Vascular disrupting agents (VDAs) damage tumor vasculature and enhance tumor radiation response. In this pre-clinical study, we combined radiation with the leading VDA in clinical development, combretastatin A-4 phosphate (CA4P), and compared the effects seen in tumors and relevant normal tissues. MATERIAL AND METHODS: Radiation was applied locally to tissues in CDF1 mice to produce full radiation dose-response curves. CA4P (250 mg/kg) was intraperitoneally (i...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28821931/targeting-angiogenesis-for-radioimmunotherapy-with-a-177-lu-labeled-antibody
#13
Emily B Ehlerding, Saige Lacognata, Dawei Jiang, Carolina A Ferreira, Shreya Goel, Reinier Hernandez, Justin J Jeffery, Charles P Theuer, Weibo Cai
PURPOSE: Increased angiogenesis is a marker of aggressiveness in many cancers. Targeted radionuclide therapy of these cancers with angiogenesis-targeting agents may curtail this increased blood vessel formation and slow the growth of tumors, both primary and metastatic. CD105, or endoglin, has a primary role in angiogenesis in a number of cancers, making this a widely applicable target for targeted radioimmunotherapy. METHODS: The anti-CD105 antibody, TRC105 (TRACON Pharmaceuticals), was conjugated with DTPA for radiolabeling with (177)Lu (t 1/2 6...
August 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28819689/beware-of-the-coronary-arteries-with-implantable-cardiac-electronic-devices
#14
REVIEW
S Serge Barold, Benjamin J Pang, Harry G Mond
The transvenous implantation of cardiac devices may sometimes cause serious complications involving the coronary arteries. The left anterior descending artery may be injured during nonapical right ventricular implantation while a right atrial lead may injure the right or circumflex coronary artery. Injury of a left internal mammary graft to a coronary artery may cause myocardial infarction.
September 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28804239/iatrogenic-great-cardiac-vein-anastomosis-during-coronary-artery-bypass-surgery
#15
Alireza Bagherli, Hilary Bews, Minh Vo, John Ducas, Davinder S Jassal, Amir Ravandi
Inadvertent anastomosis of the left internal mammary artery (LIMA) or a saphenous vein graft (SVG) to the great cardiac vein (GCV) is a rare complication of coronary artery bypass grafting (CABG). We present two cases with a LIMA to GCV and a SVG to GCV anastomosis, respectively, resulting in angina and dyspnea in the postoperative state. As an alternative to repeat CABG, both patients underwent percutaneous coronary intervention with percutaneous coil embolization or implantation of an Amplatzer vascular plug within the bypass graft to GCV conduit...
September 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28798322/luciferase-expression-allows-bioluminescence-imaging-but-imposes-limitations-on-the-orthotopic-mouse-4t1-model-of-breast-cancer
#16
V P Baklaushev, A Kilpeläinen, S Petkov, M A Abakumov, N F Grinenko, G M Yusubalieva, A A Latanova, I L Gubskiy, F G Zabozlaev, E S Starodubova, T O Abakumova, M G Isaguliants, V P Chekhonin
Implantation of reporter-labeled tumor cells in an immunocompetent host involves a risk of their immune elimination. We have studied this effect in a mouse model of breast cancer after the orthotopic implantation of mammary gland adenocarcinoma 4T1 cells genetically labelled with luciferase (Luc). Mice were implanted with 4T1 cells and two derivative Luc-expressing clones 4T1luc2 and 4T1luc2D6 exhibiting equal in vitro growth rates. In vivo, the daughter 4T1luc2 clone exhibited nearly the same, and 4T1luc2D6, a lower growth rate than the parental cells...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770293/case-series-of-patients-with-pathological-dyaphiseal-fractures-from-metastatic-bone-disease
#17
Dinu Vermesan, Radu Prejbeanu, Horia Haragus, Alis Dema, Manuel D Oprea, Diana Andrei, Dan V Poenaru, Marius Niculescu
INTRODUCTION: Fractures on pathologic bone have major impact on life quality. The appropriate treatment is not standardized, but the current literature delineates that surgery must provide adequate stabilization for the life expectancy. We aimed to review the epidemiology, treatment outcomes and survival in our department. MATERIAL AND METHODS: The electronic database from a major referral centre was searched for patients treated for tumours and fractures by the corresponding ICM-10 codes over five years...
October 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28755943/feeding-an-enhanced-diet-to-holstein-heifers-during-the-preweaning-period-alters-steroid-receptor-expression-and-increases-cellular-proliferation
#18
A J Geiger, C L M Parsons, R M Akers
Preweaning diet and estradiol treatment alters mammary development. Our objectives were to study the effects of diet and estradiol on proliferation of mammary epithelial cells and expression of estrogen receptor α (ESR1) and progesterone receptors (PGR) in these cells. Thirty-six Holstein heifer calves were raised on (1) a control milk replacer fed at 0.44 kg of powder/head per day, dry matter (DM) basis (restricted, R; 20.9% crude protein, 19.8% fat, DM basis), or (2) an enhanced milk replacer fed at 1.08 kg of powder/head per day, DM basis (Enhanced, EH; 28...
July 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28739500/breast-implant-capsule-associated-squamous-cell-carcinoma-a-report-of-2-cases
#19
Daniel L Olsen, Gary L Keeney, Beiyun Chen, Daniel W Visscher, Jodi M Carter
The use of prosthetic implants for breast augmentation has become commonplace. Although implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report 2 cases of breast implant capsule-associated squamous cell carcinoma with poor clinical outcomes. Both patients (56-year-old woman and 81-year-old woman) had long-standing implants (>25 years) and presented with acute unilateral breast enlargement. In both cases, squamous cell carcinoma arose in (focally dysplastic) squamous epithelium-lined breast implant capsules and widely invaded surrounding breast parenchyma or chest wall...
September 2017: Human Pathology
https://www.readbyqxmd.com/read/28736690/decellularization-of-human-internal-mammary-artery-biomechanical-properties-and-histopathological-evaluation
#20
Abdol-Mohammad Kajbafzadeh, Reza Khorramirouz, Seyede Maryam Kameli, Javad Hashemi, Amin Bagheri
This study undertook to create small-diameter vascular grafts and assess their structure and mechanical properties to withstand arterial implantation. Twenty samples of intact human internal mammary arteries (IMAs) were collected and decellularized using detergent-based methods. To evaluate residual cellular and extracellular matrix (ECM) components, histological analysis was performed. Moreover, collagen typing and ECM structure were analyzed by Picrosirius red and Movat's pentachrome staining. Scanning electron microscopy was also applied to assess microarchitecture of both endothelial and adventitial surfaces of native and decellularized arterial samples...
2017: BioResearch Open Access
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