keyword
https://read.qxmd.com/read/38510296/heart%C3%A2-failure-post-myocardial-infarction-promotes-mammary-tumor-growth-through-the-ngf-trka-pathway
#1
JOURNAL ARTICLE
Tetsuya Tani, Masayoshi Oikawa, Tomofumi Misaka, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Epidemiological investigations suggest that patients with heart failure have a higher incidence of cancer; however, the causal role of cardiac disease on cancer progression remains unclear. OBJECTIVES: This study aimed to investigate the impact and underlying mechanisms of myocardial infarction (MI)-induced heart failure on tumor cell growth. METHODS: We generated a syngeneic mouse model by implanting mammary tumor-derived 4T1 cells into BALB/c mice with MI resulting from ligation of the left anterior descending artery...
February 2024: JACC CardioOncology
https://read.qxmd.com/read/38471999/in-vivo-validation-of-an-in-situ-calibration-bead-as-a-reference-for-backscatter-coefficient-calculation
#2
JOURNAL ARTICLE
Yuning Zhao, Gregory J Czarnota, Trevor H Park, Rita J Miller, Michael L Oelze
OBJECTIVE: The study described here was aimed at assessing the capability of quantitative ultrasound (QUS) based on the backscatter coefficient (BSC) for classifying disease states, such as breast cancer response to neoadjuvant chemotherapy and quantification of fatty liver disease. We evaluated the effectiveness of an in situ titanium (Ti) bead as a reference target in calibrating the system and mitigating attenuation and transmission loss effects on BSC estimation. METHODS: Traditional BSC estimation methods require external references for calibration, which do not account for ultrasound attenuation or transmission losses through tissues...
March 12, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38459382/retrospective-study-on-optimizing-breast-augmentation-outcomes-in-transgender-patients-a-comprehensive-analysis-of-tumescent-local-anesthesia-technique
#3
JOURNAL ARTICLE
Matilde Tettamanzi, Federico Ziani, Manuela Rodio, Giovanni Arrica, Giovanni Muratore, Anna Manconi, Claudia Trignano, Edoardo Beatrici, Corrado Liperi, Corrado Rubino, Emilio Trignano
BACKGROUND: Tumescent local anesthesia (TLA) involves the infusion of a saline solution containing lidocaine and epinephrine into tissues to achieve localized anesthesia and vasoconstriction. While the use of TLA in sub-glandular augmentation mammoplasty has been documented, we present a modified TLA approach for primary sub-muscular breast augmentation in transgender patients based on our experience over the past years. METHODS: Between the years 2014 and 2021, we performed primary sub-muscular breast augmentation on 20 transgender patients under TLA and conscious sedation...
March 8, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38411352/super-resolution-ultrasound-imaging-for-monitoring-the-therapeutic-efficacy-of-a-vascular-disrupting-agent-in-an-animal-model-of-breast-cancer
#4
JOURNAL ARTICLE
Kenneth Hoyt
OBJECTIVE: Evaluate the use of super-resolution ultrasound (SRUS) imaging for the early detection of tumor response to treatment using a vascular-disrupting agent (VDA). METHODS: A population of 28 female nude athymic mice (Charles River Laboratories) were implanted with human breast cancer cells (MDA-MB-231, ATCC) in the mammary fat pad and allowed to grow. Ultrasound imaging was performed using a Vevo 3100 scanner (FUJIFILM VisualSonics Inc) equipped with the MX250 linear array transducer immediately before and after receiving bolus injections of a microbubble (MB) contrast agent (Definity, Lantheus Medical Imaging) via the tail vein...
February 27, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38396867/exosomes-from-adipose-tissue-derived-stem-cells-induce-proapoptotic-gene-expression-in-breast-tumor-cell-line
#5
JOURNAL ARTICLE
Oliver Felthaus, Simon Vedlin, Andreas Eigenberger, Silvan M Klein, Lukas Prantl
Lipofilling is an option for breast reconstruction after tumor resection to avoid the complications of an implant-based reconstruction. Although some concerns exist regarding the oncological safety of tissue rich in mesenchymal stem cells with their proangiogenic and proliferation-supportive properties, there are also reports that adipose-tissue-derived stem cells can exhibit antitumoral properties. We isolated primary adipose-tissue-derived stem cells. Both conditioned medium and exosomes were harvested from the cell culture and used to treat the breast cancer cell line MCF-7...
February 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38370712/-in-vivo-validation-of-an-in-situ-calibration-bead-as-a-reference-for-backscatter-coefficient-calculation
#6
Yuning Zhao, Gregory J Czarnota, Trevor H Park, Rita J Miller, Michael L Oelze
OBJECTIVES: The study aims to assess the capability of Quantitative Ul-trasound (QUS) based on the backscatter coefficient (BSC) for classifying disease states, such as breast cancer response to neoadjuvant chemotherapy and quantifying fatty liver disease. We evaluate the effectiveness of an in situ titanium (Ti) bead as a reference target in calibrating the system and mitigating attenuation and transmission loss effects on BSC estimation. METHODS: Traditional BSC estimation methods require external references for calibration, which do not account for ultrasound attenuation or transmis-sion losses through tissues...
February 9, 2024: bioRxiv
https://read.qxmd.com/read/38364672/prevalence-clinical-characteristics-and-management-of-silicone-lymphadenopathy-a-systematic-review-of-the-literature
#7
REVIEW
Tatiana C Pelegrina Perez, Anshumi Desai, Kashyap K Tadisina, Devinder P Singh, Susan B Kesmodel, Kristin E Rojas, Juan R Mella-Catinchi
INTRODUCTION: Implant-based breast augmentations and reconstructions are one of the most common surgical procedures performed by plastic surgeons in the United States, which has rapidly increased in popularity since the 2000s. Silicone lymphadenopathy (SL) is a complication of breast implants that involves migration of silicone to nearby soft tissue/lymph nodes. Data on its clinical features and management is scarce. METHODS: SL-related search terms were used to find articles in 3 databases...
March 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38352476/mimicking-the-breast-metastatic-microenvironment-characterization-of-a-novel-syngeneic-model-of-her2-breast-cancer
#8
Aaron G Baugh, Edgar Gonzalez, Valerie H Narumi, Jesse Kreger, Yingtong Liu, Christine Rafie, Sofi Castanon, Julie Jang, Luciane T Kagohara, Dimitra P Anastasiadou, James Leatherman, Todd D Armstrong, Isaac Chan, George S Karagiannis, Elizabeth M Jaffee, Adam MacLean, Evanthia T Roussos Torres
UNLABELLED: Preclinical murine models in which primary tumors spontaneously metastasize to distant organs are valuable tools to study metastatic progression and novel cancer treatment combinations. Here, we characterize a novel syngeneic murine breast tumor cell line, NT2.5-lung metastasis (- LM), that provides a model of spontaneously metastatic neu-expressing breast cancer with quicker onset of widespread metastases after orthotopic mammary implantation in immune-competent NeuN mice...
January 30, 2024: bioRxiv
https://read.qxmd.com/read/38299590/biofilm-derived-oxylipin-10-home-mediated-immune-response-in-women-with-breast-implants
#9
JOURNAL ARTICLE
Tyler M Bauer, Katherine A Gallagher
Breast implant illness (BII) is a poorly understood disease in which patients develop symptoms typical of autoimmune conditions following breast implantation. There is no known underlying cause, and patients often resort to breast implant removal and capsulectomy to alleviate symptoms. In this issue of the JCI, Khan and colleagues examined 86 breast explants from patients that reported BII symptoms and 55 control explants. The BII group showed a disproportionally high degree of biofilm, which was associated with oxylipin (10-HOME) on the implant surfaces...
February 1, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38289494/fast-ultrasound-scanning-is-a-rapid-sensitive-precise-and-cost-effective-method-to-monitor-tumor-grafts-in-mice
#10
JOURNAL ARTICLE
Sébastien Molière, Arthur Martinet, Amélie Jaulin, Massimo Lodi, Thien-Nga Chamaraux-Tran, Fabien Alpy, Guillaume Bierry, Catherine Tomasetto
In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating therapeutic interventions. Traditional methods like caliper measurements and bioluminescence imaging (BLI) have limitations, prompting the need for improved imaging techniques. This study introduces a fast-scan high-frequency ultrasound (HFUS) protocol for the longitudinal assessment of syngeneic breast tumor grafts in mice, comparing its performance with caliper, BLI measurements and with histological analysis...
January 30, 2024: Journal of Mammary Gland Biology and Neoplasia
https://read.qxmd.com/read/38254126/vascular-access-challenges-in-hemodialysis-children
#11
JOURNAL ARTICLE
Doaa M Salah, Fatina I Fadel, Mohamed A Abdel Mawla, Hesham NAbdel Mooty, Mohamed El Ghobashy, Amr M Salem, Mohamed Gamal Fathallah, Eman Abobakr Abd Alazem
BACKGROUND: Hemodialysis (HD) success is dependent mainly on vascular access (VA). The aim of this study is to share the experience of Pediatric Nephrology Unit (PNU), Cairo University Children's Hospital (CUCH), with VA-related obstacles in end stage kidney disease (ESKD) HD children. METHODS: This is a retrospective analysis of VA related data of 187 ESKD children received regular HD over 3 year duration (2019-2021). Kaplan-Meier curves were used to present arteriovenous fistula (AVF) and cuffed catheters survivals...
January 22, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38245595/tumor-growth-and-population-modeling-in-a-toxicant-stressed-random-environment
#12
JOURNAL ARTICLE
Olusegun Michael Otunuga
When examining some factors that contribute to the growth or decline of a population or tumor, it is essential to consider a random hypothesis. By analyzing the effects of stress on a population (or volume of tumor growth) in a random environment, we develop stochastic models describing the dynamics of the population (or tumor growth) based on random adjustments to the population's intrinsic growth rate, carrying capacity, and harvesting efforts (or tumor treatments). Apart from the models' ability to capture fluctuations, the availability of a shape parameter in the models gives it the flexibility to describe a variety of population/tumor data with different shapes...
January 21, 2024: Journal of Mathematical Biology
https://read.qxmd.com/read/38237631/recommendations-of-the-german-radiological-society-s-breast-imaging-working-group-regarding-breast-mri
#13
JOURNAL ARTICLE
Evelyn Wenkel, Petra Wunderlich, Eva Maria Fallenberg, Natascha Platz Batista da Silva, Heike Preibsch, Stephanie Sauer, Katja Siegmann-Luz, Stefanie Weigel, Daniel Wessling, Caroline Wilpert, Pascal Andreas Thomas Baltzer
· Breast MRI is an essential part of breast imaging. · The recommendations for performing breast MRI have been updated. · A table provides a compact and quick overview. More detailed comments supplement the table.. · The "classic" breast MRI can be performed based on the recommendations. Tips for special clinical questions, such as implant rupture, mammary duct pathology or local lymph node status, are included.. ZITIERWEISE: · Wenkel E, Wunderlich P, Fallenberg E et al. Aktualisierung der Empfehlungen der AG Mammadiagnostik der Deutschen Röntgengesellschaft zur Durchführung der Mamma-MRT...
January 18, 2024: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://read.qxmd.com/read/38230224/blockade-of-spinal-dopamine-d1-d2-receptor-heteromers-by-levo-corydalmine-suppressed-calcium-signaling-cascade-in-spinal-neurons-to-alleviate-bone-cancer-pain-in-rats
#14
JOURNAL ARTICLE
Xiao-Nan Ma, Chang-Heng Yao, Yu-Jie Yang, Xue Li, Meng-Yuan Zhou, Jin Yang, Shen Zhang, Bo-Yang Yu, Wen-Ling Dai, Ji-Hua Liu
Background: Dopamine receptors have been reported to be involved in pain, while the exact effects and mechanism in bone cancer pain have not been fully explored. Methods: Bone cancer pain model was created by implanting walker 256 mammary gland carcinoma into right tibia bone cavity. Primary cultured spinal neurons were used for in vitro evaluation. FLIPR, western-blot, immunofluorescence, and Co-IP were used to detect cell signaling pathway. Results: Our results indicated that spinal dopamine D1 receptor (D1DR) and spinal dopamine D2 receptor (D2DR) could form heteromers in TCI rats, and antagonizing spinal D1DR and D2DR reduced heteromers formation and alleviated TCI-induced bone cancer pain...
2024: Journal of Cancer
https://read.qxmd.com/read/38202217/long-stent-implantation-on-the-left-anterior-descending-coronary-artery-at-a-follow-up-of-more-than-five-years
#15
JOURNAL ARTICLE
Alessandro Sticchi, Concetta Tatali, Massimo Ferraro, Arif A Khokhar, Alessandra Scoccia, Alberto Cereda, Marco Toselli, Francesco Gallo, Alessandra Laricchia, Antonio Mangieri, Francesco Grigioni, Gian Paolo Ussia, Francesco Giannini, Antonio Colombo
BACKGROUND: Stent implantation represents the standard of care in coronary intervention. While a short stent implanted on a focal lesion located on the left anterior descending artery (LAD) seems a reasonable alternative to an internal mammary implant, the same for long stents is still debated. METHODS: We reported the long-term data of 531 consecutive patients who underwent Percutaneous Coronary Intervention (PCI) with long stents in two highly specialized centres...
December 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38199384/a-novel-translational-pet-imaging-approach-to-quantifying-distal-tumor-immune-activation-after-targeted-radiation-therapy-and-checkpoint-blockade
#16
JOURNAL ARTICLE
Yujun Zhang, Jessy S Deshane, Eddy S Yang, Benjamin Larimer
PURPOSE: This study aimed to provide a novel noninvasive method to quantify abscopal immune activation and predict combinational treatment response using [68 Ga]-NOTA-GZP positron emission tomography (PET) imaging. METHODS AND MATERIALS: 4T1 breast cancer cells were implanted bilaterally in the mammary fat pad of Balb/c mice and Lewis's lung cancer cells (LLC) were implanted bilaterally on the shoulders of C57/Bl6 mice. One of the tumors received a single fraction of 12 Gy irradiation followed by combination of concurrent PD-1 and CTLA-4 inhibitors or controls...
January 9, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38169171/subcutaneous-cardioverter-defibrillator-implantation-in-an-adult-with-congenital-heart-disease-and-left-infra-mammary-pacemaker
#17
Soham Dasgupta, Kevin Thomas, Christopher Johnsrude
The approach/type of an implantable cardioverter defibrillator (ICD) is determined by the underlying cardiac anatomy, venous access, and pre-existing cardiac implantable electronic devices. We describe a case of subcutaneous ICD implantation in an adult with congenital heart disease (CHD) with a pre-existing inframammary transvenous pacemaker. This was preferred over adding a defibrillator coil to existing pacing leads, extraction/replacement of pacing system, or a sternotomy/epicardial ICD placement. The procedure was accomplished uneventfully with successful defibrillation threshold testing...
December 31, 2023: Indian Pacing and Electrophysiology Journal
https://read.qxmd.com/read/38126640/histomorphological-evaluation-of-acellularized-bovine-pericardium-in-breast-implant-coverage
#18
JOURNAL ARTICLE
C Frutuoso Silva, V A Felzemburgh, L Q Vasconcelos, V L C Nunes, A A Barbosa Júnior, A F Giglioti, R P C Araújo, F B Miguel, J V L Meneses, F P Rosa
Bovine pericardium (BP) has been used as a biomaterial for several decades in many medical applications particularly due to its mechanical properties and the high collagen content. In the acellular form it favors faster tissue repair, providing a three-dimensional support for cellular and vascular events observed during tissue repair and due, to a low elastin content, may favor its use as a breast implant cover, resulting in a low possibility of contracture of the biomaterial, preventing the appearance of irregularities during the reconstruction process...
2023: Brazilian Journal of Biology
https://read.qxmd.com/read/38115362/perioperative-care-of-nipple-areola-complex-sparing-mastectomy-and-one-stage-breast-reconstruction-via-endoscopic-axillary-approach-for-ductal-carcinoma-in-situ-a-case-report
#19
JOURNAL ARTICLE
Li-Xia Zhang, Li Zhang, Li-Li Jiang, Hui Mi, Dong Lingling
RATIONALE: Breast cancer represents a prevalent malignancy that primarily impacts women, with pronounced consequences on their overarching health. The major therapeutic approach, encompassing surgical procedures, can often culminate in mastectomy, potentially inciting psychological turmoil and disorders. PATIENT CONCERNS: A patient was admitted to our facility on May 5, 2023, precipitated by the discovery of bilateral breast masses during a routine physical examination conducted 3 days before admission...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38114717/cough-induced-sudden-acute-chest-pain-and-massive-left-hemothorax-soon-after-pacemaker-implantation
#20
JOURNAL ARTICLE
Nicolò Martini, Federico Migliore, Raimondo Pittorru, Alessandro Rizzo, Raffaella Motta, Giulio Barbiero, Manuel De Lazzari
A 74-year-old man who recently undergone a definitive pacemaker implantation with an apical septal active lead fixation presented to the emergency department because of a new-onset acute chest pain that began soon after cough episodes. Pacemaker interrogation reported an increased bipolar pacing threshold (3.25 V at 1 ms). Contrast-enhanced chest CT scan and percutaneous angiography revealed the sequential perforation of the right ventricular apex and the left internal mammary artery by the ventricular pacemaker lead...
December 19, 2023: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
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