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Serial reaction time task

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https://www.readbyqxmd.com/read/28223958/children-and-adults-both-learn-motor-sequences-quickly-but-do-so-differently
#1
Yue Du, Nadia C Valentini, Min J Kim, Jill Whitall, Jane E Clark
Both children and adults can learn motor sequences quickly in one learning session, yet little is known about potential age-related processes that underlie this fast sequence acquisition. Here, we examined the progressive performance changes in a one-session modified serial reaction time task in 6- and 10-year-old children and adults. We found that rapid sequence learning, as reflected by reaction time (RT), was comparable between groups. The learning was expressed through two behavioral processes: online progressive changes in RT while the task was performed in a continuous manner and offline changes in RT that emerged following a short rest...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28209774/methyl-donor-supplementation-alters-cognitive-performance-and-motivation-in-female-offspring-from-high-fat-diet-fed-dams
#2
Sarah E McKee, Nicola M Grissom, Christopher T Herdt, Teresa M Reyes
During gestation, fetal nutrition is entirely dependent on maternal diet. Maternal consumption of excess fat during pregnancy has been linked to an increased risk of neurologic disorders in offspring, including attention deficit/hyperactivity disorder, autism, and schizophrenia. In a mouse model, high-fat diet (HFD)-fed offspring have cognitive and executive function deficits as well as whole-genome DNA and promoter-specific hypomethylation in multiple brain regions. Dietary methyl donor supplementation during pregnancy or adulthood has been used to alter DNA methylation and behavior...
February 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28202787/dysregulated-glycine-signaling-contributes-to-increased-impulsivity-during-protracted-alcohol-abstinence
#3
Cristina Irimia, Matthew W Buczynski, Luis A Natividad, Sarah A Laredo, Nathaniel Avalos, Loren H Parsons
Persons with alcoholism who are abstinent exhibit persistent impairments in the capacity for response inhibition, and this form of impulsivity is significantly associated with heightened relapse risk. Brain-imaging studies implicate aberrant prefrontal cortical function in this behavioral pathology, although the underlying mechanisms are not understood. Here we present evidence that deficient activation of glycine and serine release in the ventral medial prefrontal cortex (vmPFC) contributes to increased motor impulsivity during protracted abstinence from long-term alcohol exposure...
February 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28198416/a-one-week-5-choice-serial-reaction-time-task-to-measure-impulsivity-and-attention-in-adult-and-adolescent-mice
#4
Esther Remmelink, Uyen Chau, August B Smit, Matthijs Verhage, Maarten Loos
Many psychiatric disorders emerge during adolescence. The study of executive functions in animal models of these disorders critically requires short-duration tasks measuring these functions before the animal ages. Here, a novel 5-choice serial reaction time task (5-CSRTT) protocol is presented, to measure attention and impulsivity within one week, without scheduled food deprivation and with little animal handling. Mice were allowed 24-h/day task access from their home-cage, during which they could self-pace task progression and earn unlimited food rewards depending on task performance...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197651/effects-of-early-life-stress-and-adolescent-ethanol-exposure-on-adult-cognitive-performance-in-the-5-choice-serial-reaction-time-task-in-wistar-male-rats
#5
Nathalie Boutros, Andre Der-Avakian, Athina Markou, Svetlana Semenova
RATIONALE: Early life stress combined with heavy adolescent alcohol use predicts impaired neuropsychological functioning in adulthood. We investigated whether adolescent intermittent ethanol (AIE) exposure combined with neonatal maternal separation in rats altered attentional processes and impulsivity in adulthood. METHODS: Male Wistar rat pups were exposed to maternal separation (postnatal days (PNDs) 1-14) and moderate AIE exposure (PNDs 28-57). Adult rats were tested in the five-choice serial reaction time task, which provides separate measures of attention, motor impulsivity, and compulsivity...
February 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28179180/developing-a-3-choice-serial-reaction-time-task-for-examining-neural-and-cognitive-function-in-an-equine-model
#6
Kirsty Roberts, Andrew J Hemmings, Sebastian D McBride, Matthew O Parker
BACKGROUND: Large animal models of human neurological disorders are advantageous compared to rodent models due to their neuroanatomical complexity, longevity and their ability to be maintained in naturalised environments. Some large animal models spontaneously develop behaviours that closely resemble the symptoms of neural and psychiatric disorders. The horse is an example of this; the domestic form of this species consistently develops spontaneous stereotypic behaviours akin to the compulsive and impulsive behaviours observed in human neurological disorders such as Tourette's syndrome...
February 5, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28176012/implicit-learning-of-a-finger-motor-sequence-by-patients-with-cerebral-palsy-after-neurofeedback
#7
Ana Alves-Pinto, Varvara Turova, Tobias Blumenstein, Conny Hantuschke, Renée Lampe
Facilitation of implicit learning of a hand motor sequence after a single session of neurofeedback training of alpha power recorded from the motor cortex has been shown in healthy individuals (Ros et al., Biological Psychology 95:54-58, 2014). This facilitation effect could be potentially applied to improve the outcome of rehabilitation in patients with impaired hand motor function. In the current study a group of ten patients diagnosed with cerebral palsy trained reduction of alpha power derived from brain activity recorded from right and left motor areas...
February 7, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28168926/stimulation-of-nicotinic-acetylcholine-alpha7-receptors-rescue-schizophrenia-like-cognitive-impairments-in-rats
#8
Agnieszka Potasiewicz, Agnieszka Nikiforuk, Małgorzata Hołuj, Piotr Popik
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) dysfunction plays an important role in schizophrenia. Positive allosteric modulators of α7 nAChR have emerged as a promising therapeutic approach to manage cognitive deficits that are inadequately treated in schizophrenic patients. The aim of the present study was to evaluate the ability of type I (CCMI) and type II (PNU120596) α7 nAChR positive allosteric modulators to counteract MK-801-induced cognitive and sensorimotor gating deficits. The activity of these compounds was compared with the action of the α7 nAChR agonist A582941...
February 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28150963/a-specific-implicit-sequence-learning-deficit-as-an-underlying-cause-of-dyslexia-investigating-the-role-of-attention-in-implicit-learning-tasks
#9
Eva Staels, Wim Van den Broeck
OBJECTIVE: Recently, a general implicit sequence learning deficit was proposed as an underlying cause of dyslexia. This new hypothesis was investigated in the present study by including a number of methodological improvements, for example, the inclusion of appropriate control conditions. The second goal of the study was to explore the role of attentional functioning in implicit and explicit learning tasks. METHOD: In a 2 × 2 within-subjects design 4 tasks were administered in 30 dyslexic and 38 control children: an implicit and explicit serial reaction time (RT) task and an implicit and explicit contextual cueing task...
February 2, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28138754/motor-sequence-learning-and-the-effect-of-context-on-transfer-from-part-to-whole-and-from-whole-to-part
#10
Zipi Rhein, Eli Vakil
The present study attempts to characterize the contextual conditions (i.e., addition versus omission of elements) that enable or prevent transfer of an acquired skill. The effect of learning and transfer from part-to-whole and from whole-to-part was studied with the serial reaction time (SRT) task. In this study, two alternative sequences of the SRT task were utilized, a short (i.e., 'part') sequence consisting of six elements (ADBACD), and a long (i.e., 'whole') one consisting of 12 elements (BDCADBACDABC) in which the short sequence was embedded...
January 30, 2017: Psychological Research
https://www.readbyqxmd.com/read/28110352/effects-of-methylphenidate-on-attention-in-wistar-rats-treated-with-the-neurotoxin-n-2-chloroethyl-n-ethyl-2-bromobenzylamine-dsp4
#11
Joachim Hauser, Andreas Reissmann, Thomas-A Sontag, Oliver Tucha, Klaus W Lange
The aim of this study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on attention in rats as measured using the 5-choice-serial-reaction-time task (5CSRTT) and to investigate whether methylphenidate has effects on DSP4-treated rats. Methylphenidate is a noradrenaline and dopamine reuptake inhibitor and commonly used in the pharmacological treatment of individuals with attention deficit/hyperactivity disorder (ADHD). Wistar rats were trained in the 5CSRTT and treated with one of three doses of DSP4 or saline...
January 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28093027/effects-of-amphetamine-and-methylphenidate-on-attentional-performance-and-impulsivity-in-the-mouse-5-choice-serial-reaction-time-task
#12
Maitane Caballero-Puntiverio, Ciarán Martin Fitzpatrick, David Pd Woldbye, Jesper Tobias Andreasen
BACKGROUND: Few studies have investigated the effects of conventional attention deficit-hyperactivity disorder (ADHD) medication in the mouse 5-choice serial reaction time task (5-CSRTT), and rat studies have yielded inconsistent results. OBJECTIVE: We aimed to examine the effects of acute methylphenidate (MPH) and amphetamine (AMPH) treatment in the mouse 5-CSRTT. METHODS: Trained male C57Bl/6J mice were tested in a variable stimulus duration schedule...
February 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28087221/varenicline-provokes-impulsive-action-by-stimulating-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-in-the-infralimbic-cortex-in-a-nicotine-exposure-status-dependent-manner
#13
Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
Higher impulsivity is a risk factor for criminal involvement and drug addiction. Because nicotine administration enhances impulsivity, the effects of stop-smoking aids stimulating nicotinic acetylcholine receptors (nAChRs) on impulsivity must be determined in different conditions. Our goals were 1) to confirm the relationship between varenicline, a stop-smoking aid and α4β2 nAChR partial agonist, and impulsivity, 2) to elucidate the mechanisms underlying the effects of varenicline, 3) to examine whether a low dose of varenicline that does not evoke impulsive action could block the stimulating effects of nicotine on impulsive action, 4) to determine whether the route of administration could modulate the effects of varenicline on impulsive action, and 5) to determine whether the effects of varenicline on impulsivity could be altered by smoking status...
January 10, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28070619/theory-of-visual-attention-tva-applied-to-mice-in-the-5-choice-serial-reaction-time-task
#14
C M Fitzpatrick, M Caballero-Puntiverio, U Gether, T Habekost, C Bundesen, S Vangkilde, D P D Woldbye, J T Andreasen, A Petersen
RATIONALE: The 5-choice serial reaction time task (5-CSRTT) is widely used to measure rodent attentional functions. In humans, many attention studies in healthy and clinical populations have used testing based on Bundesen's Theory of Visual Attention (TVA) to estimate visual processing speeds and other parameters of attentional capacity. OBJECTIVES: We aimed to bridge these research fields by modifying the 5-CSRTT's design and by mathematically modelling data to derive attentional parameters analogous to human TVA-based measures...
January 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28005989/action-video-game-playing-is-reflected-in-enhanced-visuomotor-performance-and-increased-corticospinal-excitability
#15
Olivier Morin-Moncet, Jean-Marc Therrien-Blanchet, Marie C Ferland, Hugo Théoret, Greg L West
Action video game playing is associated with improved visuomotor performance; however, the underlying neural mechanisms associated with this increased performance are not well understood. Using the Serial Reaction Time Task in conjunction with Transcranial Magnetic Stimulation, we investigated if improved visuomotor performance displayed in action video game players (actionVGPs) was associated with increased corticospinal plasticity in primary motor cortex (M1) compared to non-video game players (nonVGPs). Further, we assessed if actionVGPs and nonVGPs displayed differences in procedural motor learning as measured by the SRTT...
2016: PloS One
https://www.readbyqxmd.com/read/27992442/is-implicit-motor-learning-preserved-after-stroke-a-systematic-review-with-meta-analysis
#16
E Kal, M Winters, J van der Kamp, H Houdijk, E Groet, C van Bennekom, E Scherder
Many stroke patients experience difficulty with performing dual-tasks. A promising intervention to target this issue is implicit motor learning, as it should enhance patients' automaticity of movement. Yet, although it is often thought that implicit motor learning is preserved post-stroke, evidence for this claim has not been systematically analysed yet. Therefore, we systematically reviewed whether implicit motor learning is preserved post-stroke, and whether patients benefit more from implicit than from explicit motor learning...
2016: PloS One
https://www.readbyqxmd.com/read/27899713/when-do-individuals-with-autism-spectrum-disorder-show-superiority-in-visual-search
#17
Aya Shirama, Nobumasa Kato, Makio Kashino
Although superior visual search skills have been repeatedly reported for individuals with autism spectrum disorder, the underlying mechanisms remain controversial. To specify the locus where individuals with autism spectrum disorder excel in visual search, we compared the performance of autism spectrum disorder adults and healthy controls in briefly presented search tasks, where the search display was replaced by a noise mask at a stimulus-mask asynchrony of 160 ms to interfere with a serial search process while bottom-up visual processing remains intact...
November 29, 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/27872374/what-s-statistical-about-learning-insights-from-modelling-statistical-learning-as-a-set-of-memory-processes
#18
REVIEW
Erik D Thiessen
Statistical learning has been studied in a variety of different tasks, including word segmentation, object identification, category learning, artificial grammar learning and serial reaction time tasks (e.g. Saffran et al. 1996 Science 274: , 1926-1928; Orban et al. 2008 Proceedings of the National Academy of Sciences 105: , 2745-2750; Thiessen & Yee 2010 Child Development 81: , 1287-1303; Saffran 2002 Journal of Memory and Language 47: , 172-196; Misyak & Christiansen 2012 Language Learning 62: , 302-331). The difference among these tasks raises questions about whether they all depend on the same kinds of underlying processes and computations, or whether they are tapping into different underlying mechanisms...
January 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27846219/pharmacological-fingerprints-of-contextual-uncertainty
#19
Louise Marshall, Christoph Mathys, Diane Ruge, Archy O de Berker, Peter Dayan, Klaas E Stephan, Sven Bestmann
Successful interaction with the environment requires flexible updating of our beliefs about the world. By estimating the likelihood of future events, it is possible to prepare appropriate actions in advance and execute fast, accurate motor responses. According to theoretical proposals, agents track the variability arising from changing environments by computing various forms of uncertainty. Several neuromodulators have been linked to uncertainty signalling, but comprehensive empirical characterisation of their relative contributions to perceptual belief updating, and to the selection of motor responses, is lacking...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27844059/developmental-ethanol-exposure-leads-to-long-term-deficits-in-attention-and-its-underlying-prefrontal-circuitry
#20
Emma L Louth, Warren Bignell, Christine L Taylor, Craig D C Bailey
Chronic prenatal exposure to ethanol can lead to a spectrum of teratogenic outcomes that are classified in humans as fetal alcohol spectrum disorders (FASD). One of the most prevalent and persistent neurocognitive components of FASD is attention deficits, and it is now thought that these attention deficits differ from traditional attention deficit hyperactivity disorder (ADHD) in their quality and response to medication. However, the neuronal mechanisms underlying attention deficits in FASD are not well understood...
September 2016: ENeuro
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