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Antioxidant enzymes

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https://www.readbyqxmd.com/read/29334666/effects-of-berberine-chloride-on-the-liver-of-streptozotocin-induced-diabetes-in-albino-wistar-rats
#1
Govindasami Chandirasegaran, Chakkaravarthy Elanchezhiyan, Kavisa Ghosh
The goal of the present study is to evaluate the effect of Berberine chloride (BC) on the liver of streptozotocin (STZ) induced diabetic rat. Diabetic rats were treated with BC (50 mg/kg b.w) or glibenclamide (6 mg/kg b.w), daily for 45 days. After BC treatment in diabetic rats, there was a significant (P < 0.05) decline in the levels of hepatic markers, lipid peroxidation markers such as lipid hydroperoxides (LOOH) and thiobarbituric acid reactive substances (TBARS), and pro-inflammatory mediators like tumor necrosis factor-alpha (TNF-α), phosphorylated nuclear factor kappa-B-p65 (phospho-NF-κB p65), cyclooxygenase (COX-2), nitric oxide synthase (iNOS) as well as pro-apoptotic mediators such as Bax and cytochrome c...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334662/aqueous-extracts-of-two-tropical-ethnobotanicals-tetrapleura-tetraptera-and-quassia-undulata-improved-spatial-and-non-spatial-working-memories-in-scopolamine-induced-amnesic-rats-influence-of-neuronal-cholinergic-and-antioxidant-systems
#2
Veronica O Odubanjo, Emmanuel O Ibukun, Ganiyu Oboh, Stephen A Adefegha
BACKGROUND: Tetrapleura tetraptera (TT) and Quassia undulata (QU) are two predominant tropical ethnobotanicals with various medicinal values but are commonly used in folklore for the treatment of mental illness without justifiable mechanisms of action. AIM OF THE STUDY: To investigate the effects of aqueous extracts from TT fruits and QU leaves on the spatial and non-spatial working memory, antioxidant status and activities of neuronal marker enzymes of scopolamine-induced amnesic rats and thus, understand the possible mechanism of action of these plants...
January 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334650/environmentally-relevant-concentrations-of-glibenclamide-induce-oxidative-stress-in-common-carp-cyprinus-carpio
#3
Ericka María Guadalupe Martínez-Viveros, Hariz Islas-Flores, Octavio Dublán-García, Marcela Galar-Martínez, Nely SanJuan-Reyes, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván
The hypoglycemic pharmaceutical glibenclamide (GLB) is widely used around the world. This medication is released into the environment by municipal, hospital and industrial wastewater discharges. Although there are reports of its environmental occurrence in the scientific literature, toxicity studies on aquatic species of commercial interest such as the common carp Cyprinus carpio are scarce. The present study aimed to evaluate the oxidative stress induced on C. carpio by environmentally relevant concentrations of GLB...
January 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29334408/effects-of-metalaxyl-enantiomers-stress-on-root-activity-and-leaf-antioxidant-enzyme-activities-in-tobacco-seedlings
#4
Song Fang, Yi Tao, Yizhi Zhang, Fanyu Kong, Yunbai Wang
The objective of this experiment was to study the effects of metalaxyl enantiomers on the activity of roots and antioxidative enzymes in tobacco seedlings. Water culture experiment was conducted to analyze the effects of different concentrations of metalaxyl enantiomers (30 and 10 mg L-1 ) on root activity and leaf superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) activities and malondialdehyde (MDA) content of tobacco seedlings. The results showed that metalaxyl significantly inhibited root activity and significantly improved leaf SOD, POD, and CAT activities and MDA content...
January 15, 2018: Chirality
https://www.readbyqxmd.com/read/29334211/curcumin-and-quercetin-ameliorated-cypermethrin-and-deltamethrin-induced-reproductive-system-impairment-in-male-wistar-rats-by-upregulating-the-activity-of-pituitary-gonadal-hormones-and-steroidogenic-enzymes
#5
Poonam Sharma, Irshad Aslam Khan, Rambir Singh
Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats. MATERIALS AND METHODS: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29333393/effect-of-monascus-fermented-soybean-extracts-on-antioxidant-and-skin-aging-related-enzymes-inhibitory-activities
#6
Yoo-Jeong Jin, Young-Hee Pyo
We investigated the in vitro inhibitory activity against skin aging-related enzymes and antioxidant activity of Monascus-fermented soybean extracts (MFSEs) obtained by using different solvents. The highest Trolox equivalent (TE) antioxidant capacity (3.13±0.06 mM TE/g) and oxygen radical absorbance capacity (2.79±0.09 mM TE/g) of MFSEs were evaluated for the methanol and 80% ethanol extracts, respectively. The antioxidant capacities increased with increasing concentration (0.5~50 mg/mL). In addition, the methanol and 80% ethanol extracts showed an effective inhibition against tyrosinase, hyaluronidase, and elastase compared with those of acetone and hot water extracts (P<0...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333384/antioxidant-and-cytoprotective-activities-of-enzymatic-extracts-from-rhizoid-of-laminaria-japonica
#7
Jae-Young Je, Soo Yeon Park, Chang-Bum Ahn
Rhizoid of Laminaria japonica was hydrolyzed with proteases and carbohydrases to obtain antioxidant materials. Oxygen radical absorbance capacity (ORAC) of the enzymatic extracts was evaluated and the Protamex extract (PE) exhibited the highest ORAC value. PE also potently scavenged 2,2-diphenyl-1-picrylhydrazyl radical, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic) acid cation radical, and hydrogen peroxide (H2O2) and had good reducing power. PE inhibited hydroxyl radical-induced DNA scission by measuring the conversion of supercoiled pBR322 plasmid DNA to the open circular form...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333048/astaxanthin-ameliorates-hepatic-damage-and-oxidative-stress-in-carbon-tetrachloride-administered-rats
#8
Md Ariful Islam, Md Abdullah Al Mamun, Md Faruk, Md Tauhid Ul Islam, Md Mizanur Rahman, Mohammad Nazmul Alam, A F M Towheedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Background: Astaxanthin is of carotenoids group which possess strong antioxidant properties. The present study was conducted to evaluate the hepatoprotective effects of astaxanthin in carbon tetrachloride (CCl4)-treated rats. Materials and Methods: Female Long-Evans rats were administered with CCl4 orally (1 ml/kg) twice a week for 2 weeks and were treated with astaxanthin (10 mg/kg) every day for 2 weeks. Blood plasma samples were isolated from each group and were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase activities...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29331724/diminution-of-arsenic-accumulation-in-rice-seedlings-co-cultured-with-anabaena-sp-modulation-in-the-expression-of-lower-silicon-transporters-two-nitrogen-dependent-genes-and-lowering-of-antioxidants-activity
#9
Ruma Ranjan, Navin Kumar, Arvind Kumar Dubey, Ambedkar Gautam, Shyam Narain Pandey, Shekhar Mallick
The present study was intended to investigate the role of algae, Anabaena sp. in the amelioration of As toxicity, when co-cultured with rice seedlings. The reduction of growth in rice seedlings against As(III) and As(V) was recovered with Anabaena sp. The Anabaena sp. also reduced the accumulation of As, where it was more efficient against 60µM As(III) (49%) than As(V) (23%) in rice shoot. Similarly, with reduction of As accumulation, lower silicon transporters (Lsi-1 and Lsi-2) was found to be suppressed against As treatments...
January 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29331653/gallic-acid-attenuates-type-i-diabetic-nephropathy-in-rats
#10
Mayuresh Sudamrao Garud, Yogesh Anant Kulkarni
Literatures suggest that TGF-β1 have a central role in the progression of diabetic nephropathy and its down regulation can improve the disease condition. Oxidative stress, generation of advanced glycation end products and activation of renin angiotensin system are the connecting links between hyperglycemia and TGF-β1 over expression. Gallic acid is a phytochemical having wide range of biological activities. Gallic acid is reported to have antioxidant and advanced glycation inhibitory activity. It has also shown inhibitory effects on angiotensin converting enzyme...
January 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29330822/biochemical-changes-in-mussels-submitted-to-different-time-periods-of-air-exposure
#11
Madalena Andrade, Amadeu Soares, Etelvina Figueira, Rosa Freitas
Intertidal species face multiple stressors on a daily basis due to their particular habitat. The submergence at high tide in the aquatic environment and emergence at low tide to the aerial environment, associated with a wide variation of abiotic parameters, along with anthropogenic contamination are some of the daily stresses that these organisms are exposed to. With such a dynamic environment, organisms developed strategies that allow them to avoid or tolerate these stressors. Among these species, bivalves are some of the most hypoxia tolerant, being commonly used as a biomonitoring tool due to their capacity to accumulate pollutants from the environment and reflect the imposed toxic impacts...
January 13, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29329854/enzymatic-preparation-of-functional-oil-rich-in-feruloylated-structured-lipids-with-solvent-free-ultrasound-pretreatment
#12
Haiping Zhang, Mingming Zheng, Jie Shi, Hu Tang, Qianchun Deng, Fenghong Huang, Dan Luo
In this study, a series of functional oils rich in feruloylated structured lipids (FSLs) was prepared by enzymatic transesterification of ethyl ferulate (EF) with triglycerides under ultrasound pretreatment. A conversion of more than 92.7% and controllable FSLs (3.1%-26.3%) can be obtained under the following conditions: 16% enzyme, substrate ratio 1:5 (oil/EF, mol/mol), 85 °C, ultrasound 1 h, pulse mode 3 s/3s (working/waiting), and 17.0 W/mL. Compared to conventional mechanical stirring, the activation energy decreased from 50...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329853/ph-controlled-fermentation-in-mild-alkaline-conditions-enhances-bioactive-compounds-and-functional-features-of-lentil-to-ameliorate-metabolic-disturbances
#13
Sara Bautista-Expósito, Elena Peñas, José Manuel Silván, Juana Frias, Cristina Martínez-Villaluenga
Lentil fermentation has a promising potential as a strategy for development of multifunctional ingredients targeting metabolic syndrome (MetS). Response surface methodology was applied to optimize lentil fermentation and study its effects on generation of peptides, soluble phenolics and bioactivities. Fermentation using Lactobacillus plantarum and Savinase® 16 L was carried out at different pH (6.5-8.5) and times (5.5-30 h). Analysis of variance was performed to evaluate linear, quadratic and interaction effects between fermentation parameters...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329843/partial-substitution-of-nacl-by-kcl-and-addition-of-flavor-enhancers-on-probiotic-prato-cheese-a-study-covering-manufacturing-ripening-and-storage-time
#14
Hugo L A Silva, Celso F Balthazar, Erick A Esmerino, Roberto P C Neto, Ramon S Rocha, Jeremias Moraes, Rodrigo N Cavalcanti, Robson M Franco, Maria Inês B Tavares, Jânio S Santos, Daniel Granato, Renata G B Costa, Mônica Q Freitas, Márcia C Silva, Renata S L Raices, C Senaka Ranadheera, Filomena Nazzaro, Amir M Mortazavian, Adriano G Cruz
Cheese is a suitable matrix to deliver probiotic strains but it contains a high amount of sodium. The effect of partial substitution of NaCl by KCl and the addition of flavor enhancers (l-arginine, yeast and oregano extract) on probiotic Prato cheese was investigated after 1, 30, and 60 d of refrigerated storage (immediately after manufacturing, and during ripening and storage). Microbiological (lactic acid bacteria and probiotic Lactobacillus casei 01 counts and survival under gastrointestinal conditions), physicochemical (pH, proteolysis, fatty acids), bioactivity (antioxidant effect and angiotensin I-converting enzyme inhibitory activity), rheological, and water mobility by means of time domain low-field nuclear magnetic resonance were investigated...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329610/bacopa-monnieri-extracts-prevent-hydrogen-peroxide-induced-oxidative-damage-in-a-cellular-model-of-neuroblastoma-imr32-cells
#15
Gaurav Bhatia, Vikram Dhuna, Kshitija Dhuna, Manpreet Kaur, Jatinder Singh
Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is well known for its nerve relaxing and memory enhancing properties. The present study was designed to evaluate the protective effects of extracts from Bacopa monnieri against H2O2 induced oxidative stress using a cellular model, neuroblastoma IMR32 cell line...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329609/garcinia-xanthochymus-extract-protects-pc12-cells-from-h2o2-induced-apoptosis-through-modulation-of-pi3k-akt-and-nrf2-ho-1-pathways
#16
Jing Xu, Sheng Gan, Jun Li, De-Bing Wand, Yu Chen, Xin Hu, Guang-Zhong Yang
The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit EtOAc fraction (fruit-EFr., 12.5-50 µmol·L-1) of G. xanthochymus for 24 h prior to H2O2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes (superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases (MMP), and scavenged reactive oxygen species (ROS)...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329033/onjisaponin-b-prevents-cognitive-impairment-in-a-rat-model-of-d-galactose-induced-aging
#17
Gaowen Li, Jimian Yu, Ling Zhang, Yong Wang, Chuang Wang, Qun Chen
In this study, we investigated the potential effect of onjisaponin B (OB) on aging rats induced by D-gal (D-galactose). Sub-acute aging model was established in rats by the subcutaneous injection of D-gal (120 mg/kg) for 42 days, accompanied with OB (10, 20 mg/kg, p.o.) or normal saline intervention for 28 days since the 14th day after the beginning of D-gal stimulation. Morris water maze test and step-down passive avoidance test were conducted to evaluate the cognitive function of the rats. The superoxidase dismutase (SOD), malondialdehyde (MDA), glutathione (GSH) and glutathione peroxidase (GSH-px) contents in hippocampus were measured by according kits, respectively...
January 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29329013/antiobesity-effect-of-lactobacillus-reuteri-263-associated-with-energy-metabolism-remodeling-of-white-adipose-tissue-in-high-energy-diet-fed-rats
#18
Li-Han Chen, Yi-Hsing Chen, Kuan-Chen Cheng, Ting-Yi Chien, Ching-Hung Chan, Shu-Ping Tsao, Hui-Yu Huang
Obesity is a serious and costly issue to the medical welfare worldwide. Probiotics have been suggested as one of the candidates to resolve the obesity-associated problems, but how they combat obesity is not fully understood. Herein, we investigated the effects of Lactobacillus reuteri 263 (L. reuteri 263) on antiobesity using four groups of Sprague-Dawley rats (n=10/group), namely, C (normal diet with vehicle treatment), HE [high-energy diet (HED) with vehicle treatment], 1X (HED with 2.1×109 CFU/kg/day of L...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29328478/arctigenin-exerts-protective-effects-against-myocardial-infarction-via-regulation-of-inos-cox%C3%A2-2-erk1-2-and-ho%C3%A2-1-in-rats
#19
Yanmin Zhang, Yong Yang
The present study aimed to determine the protective effects of arctigenin against myocardial infarction (MI), and its effects on oxidative stress and inflammation in rats. Left anterior coronary arteries of Sprague‑Dawley rats were ligated, in order to generate an acute MI (AMI) model. Arctigenin was administered to AMI rats at 0, 50, 100 or 200 µmol/kg. Western blotting and ELISAs were performed to analyze protein expression and enzyme activity. Arctigenin was demonstrated to effectively inhibit the levels of alanine transaminase, creatine kinase‑MB and lactate dehydrogenase, and to reduce infarct size in AMI rats...
January 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327633/biochemical-basis-for-the-age-related-sensitivity-of-broilers-to-aflatoxin-b1
#20
He Wang, Wei Li, Ishfaq Muhammad, Xiaoqi Sun, Xiaoxu Cui, Ping Cheng, Qayum Abdul, Xiuying Zhang
In this study, we investigated the mechanism underlying age-related susceptibility in broilers to aflatoxin B1 (AFB1). The results showed that AFB1 induced significant changes in serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) activity & liver superoxide dismutase (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) activity at day 7, 21 and 42 relative to control group. However, AFB1-induced changes in serum biochemical parameters and liver antioxidant activities becomes less severe with increasing age of broilers...
January 12, 2018: Toxicology Mechanisms and Methods
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