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https://www.readbyqxmd.com/read/28087437/hydrogen-rich-saline-attenuates-hippocampus-endoplasmic-reticulum-stress-after-cardiac-arrest-in-rats
#1
Yu Gao, Qinfang Gui, Li Jin, Pan Yu, Lin Wu, Liangbin Cao, Qiang Wang, Manlin Duan
BACKGROUND: Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest. METHODS: The rats were randomly divided into three groups, sham group (n=30), ischemia/reperfusion group (n=40) and hydrogen-rich saline group (n=40)...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28087255/unknown-face-of-known-drugs-what-else-can-we-expect-from-angiotensin-converting-enzyme-inhibitors
#2
REVIEW
Anna Wzgarda, Robert Kleszcz, Monika Prokop, Katarzyna Regulska, Milosz Regulski, Jaroslaw Paluszczak, Beata J Stanisz
The renin-angiotensin system (RAS) is one of important systems among homeostatic mechanisms that controls the function of cardiovascular, renal and adrenal systems. As RAS has a very complex nature, it has been also found as related to the control of cell migration and apoptosis. Angiotensin-converting enzyme inhibitors (ACEI) are drugs most commonly used in the modulation of RAS activity. ACEI have been extensively described as effective in the treatment of hypertension among adults, but also as drugs delaying progression in diabetic nephropathy and reducing mortality in left ventricular dysfunction and congestive heart failure...
January 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28087233/anti-diabetic-effects-of-inonotus-obliquus-polysaccharides-chromium-iii-complex-in-type-2-diabetic-mice-and-its-sub-acute-toxicity-evaluation-in-normal-mice
#3
Cong Wang, Zhongqin Chen, Yuxiang Pan, Xudong Gao, Haixia Chen
Polysaccharides are important bioactive ingredients from Inonotus obliquus. This study aimed to synthesize and characterize a novel I. obliquus polysaccharides-chromium (III) complex (UIOPC) and investigate the anti-diabetic effects in streptozotocin (STZ) induced type 2 diabetes mellitus (T2DM) mice and sub-acute toxicity in normal mice. The molecular weight of UIOPC was about 11.5 × 10 (4) Da with the chromium content was 13.01% and the chromium was linked with polysaccharides through coordination bond...
January 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28086894/c60-fullerene-as-promising-therapeutic-agent-for-correcting-and-preventing-skeletal-muscle-fatigue
#4
Yurij I Prylutskyy, Inna V Vereshchaka, Andriy V Maznychenko, Nataliya V Bulgakova, Olga O Gonchar, Olena A Kyzyma, Uwe Ritter, Peter Scharff, Tomasz Tomiak, Dmytro M Nozdrenko, Iryna V Mishchenko, Alexander I Kostyukov
BACKGROUND: Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats. RESULTS: During fatigue development, we observed decrease in the muscle effort level before C60FAS administration...
January 13, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28086854/in-vitro-assessment-of-hepatoprotective-agents-against-damage-induced-by-acetaminophen-and-ccl4
#5
Liliana Torres González, Noemí Waksman Minsky, Linda Elsa Muñoz Espinosa, Ricardo Salazar Aranda, Jonathan Pérez Meseguer, Paula Cordero Pérez
BACKGROUND: In vitro bioassays are important in the evaluation of plants with possible hepatoprotective effects. The aims of this study were to evaluate the pretreatment of HepG2 cells with hepatoprotective agents against the damage induced by carbon tetrachloride (CCl4) and paracetamol (APAP). METHODS: Antioxidative activity was measured using an assay to measure 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. The in vitro hepatotoxicity of CCl4 and APAP, and the cytotoxic and hepatoprotective properties of silymarin (SLM), silybinin (SLB), and silyphos (SLP) were evaluated by measuring cell viability; activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH); total antioxidant capacity (TAOxC); and reduced glutathione (GSH), superoxide dismutase (SOD), and lipid peroxidation (malondialdehyde (MDA) levels)...
January 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28081574/gstp1-and-cyp2b6-genetic-polymorphisms-and-the-risk-of-bronchopulmonary-dysplasia-in-preterm-neonates
#6
Sophia Zachaki, Aggeliki Daraki, Elena Polycarpou, Chrysa Stavropoulou, Kalliopi N Manola, Stavroula Gavrili
Objectives Antioxidant response plays a key role in bronchopulmonary dysplasia (BPD) pathogenesis. The glutathione-S-tranferases pi 1 (GSTP1) and cytochrome P450 (CYP) detoxification enzymes protect cells from oxidative damage. The aim of the study was to investigate whether the A(313)G GSTP1 and G(516)T CYP2B6 inactivating polymorphisms could be associated with BPD susceptibility. Study Design To test this hypothesis, we conducted a case-control study enrolled 138 premature neonates ≤32 weeks of gestational age; of the 138, 46 developed BPD and 92 did not develop BPD...
January 12, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28081489/protective-effect-of-chitosan-on-photosynthesis-and-antioxidative-defense-system-in-edible-rape-brassica-rapa-l-in-the-presence-of-cadmium
#7
Haiying Zong, Song Liu, Ronge Xing, Xiaolin Chen, Pengcheng Li
Chitosan (CTS) induces plant tolerance against several abiotic stresses, including salinity and drought exposure. However, the role of CTS in cadmium (Cd)-induced stress amelioration is largely unknown. In the present study, a hydroponic pot experiment was conducted to study the roles of CTS with different molecular weight (Mw) (10kDa,5kDa and 1kDa) in alleviating Cd toxicity in edible rape (Brassica rapa L .). The results showed that Cd stress significantly decreased plant growth, leaf chlorophyll contents and increased the malondialdehyde (MDA) level in rape leaves...
January 9, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28081247/changes-of-oxidative-stress-glutathione-and-its-dependent-antioxidant-enzyme-activities-in-patients-with-hepatocellular-carcinoma-before-and-after-tumor-resection
#8
Shao-Bin Cheng, Hsiao-Tien Liu, Sin-Yuan Chen, Ping-Ting Lin, Chia-Yu Lai, Yi-Chia Huang
The changes in and relationship between oxidative stress and the glutathione (GSH) antioxidant system in the plasma and tissues of patients with hepatocellular carcinoma (HCC) before and after tumor resection have not been clearly determined. We investigated the changes in oxidative stress, GSH status and its dependent antioxidant enzyme activities in HCC patients before and after tumor resection, and to determine the association of oxidative stress with GSH and its dependent antioxidant enzyme activities in plasma and tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28081213/transcriptome-profiling-to-understand-the-effect-of-citrus-rootstocks-on-the-growth-of-shatangju-mandarin
#9
Xiang-Yu Liu, Juan Li, Meng-Meng Liu, Qing Yao, Jie-Zhong Chen
To obtain insight into potential mechanisms underlying the influence of rootstock on scion growth, we performed a comparative analysis of 'Shatangju' mandarin grafted onto 5 rootstocks: Fragrant orange (Citrus junons Sieb. ex. Tanaka), Red tangerine (Citrus reticulata Blanco), 'Shatangju' mandarin (Citrus reticulata Blanco), Rough lemon (Citrus jambhiri Lush) and Canton lemon (Citrus limonia Osbeck). The tree size of 'Shatangju' mandarin grafted onto Canton lemon and Rough lemon were the largest, followed by self-rooted rootstock trees, and the lowest tree sizes correspond to ones grafted on Red tangerine and Fragrant orange rootstocks...
2017: PloS One
https://www.readbyqxmd.com/read/28081181/aronia-melanocarpa-extract-ameliorates-hepatic-lipid-metabolism-through-ppar%C3%AE-2-downregulation
#10
Chung-Hwa Park, Jung-Hee Kim, Eun Byul Lee, Wonhee Hur, Oh-Joo Kwon, Hyoung-Jin Park, Seung Kew Yoon
Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Studies have demonstrated that anthocyanin-rich foods may improve hyperlipidemia and ameliorate hepatic steatosis. Here, effects of Aronia melanocarpa (AM), known to be rich of anthocyanins, on hepatic lipid metabolism and adipogenic genes were determined. AM was treated to C57BL/6N mice fed with high fat diet (HFD) or to FL83B cells treated with free fatty acid (FFA). Changes in levels of lipids, enzymes and hormones were observed, and expressions of adipogenic genes involved in hepatic lipid metabolism were detected by PCR, Western blotting and luciferase assay...
2017: PloS One
https://www.readbyqxmd.com/read/28078521/exogenously-applied-poly-%C3%AE-glutamic-acid-alleviates-salt-stress-in-wheat-seedlings-by-modulating-ion-balance-and-the-antioxidant-system
#11
Zhengfei Guo, Na Yang, Changhua Zhu, Lijun Gan
Salt stress is a main abiotic stress that limits agricultural productivity in many parts of the world. To investigate whether poly-γ-glutamic acid (γ-PGA) can alleviate the negative effects of salt stress on wheat, a foliar application of 400 mg/L γ-PGA was applied to wheat seedlings, which were then subjected to 150 mM NaCl. Our results showed that after application of γ-PGA, the plant height, the plant weight, and the antioxidant enzymes including superoxide dismutase, peroxidase, and catalase were significantly increased compared with the treatment of 150 mM NaCl alone...
January 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28078262/the-leaf-of-diospyros-kaki-thumb-ameliorates-renal-oxidative-damage-in-mice-with-type-2-diabetes
#12
Myung-Sook Choi, Mi Ji Jeong, Yong Bok Park, Sang Ryong Kim, Un Ju Jung
Diabetic kidney disease is the most common and severe chronic complication of diabetes. The leaf of Diospyros kaki Thumb (persimmon) has been commonly used for herbal tea and medicinal purposes to treat a variety of conditions, including hypertension and atherosclerosis. However, the effect of persimmon leaf on kidney failure has not been investigated. This study aimed to examine the role of persimmon leaf in protecting the diabetes-associated kidney damage in a mouse model of type 2 diabetes. Mice were fed either a normal chow diet with or without powered persimmon leaf (5%, w/w) for 5 weeks...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28078249/effects-of-urtica-dioica-supplementation-on-blood-lipids-hepatic-enzymes-and-nitric-oxide-levels-in-type-2-diabetic-patients-a-double-blind-randomized-clinical-trial
#13
Alidad Amiri Behzadi, Hamid Kalalian-Moghaddam, Amir Hossein Ahmadi
OBJECTIVE: Oxidative stress plays an important role in the development of diabetic complications including metabolic abnormality-induced diabetic micro-vascular and macro-vascular complications. Urtica dioica L. (U. dioica) has been traditionally used in Iranian medicine as an herbal remedy for hypoglycemic or due to its anti-inflammatory properties. The aim of the present study was to evaluate the effects of hydro-alcoholic extract of U. dioica on blood lipids, hepatic enzymes and nitric oxide levels in patients with type 2 diabetes mellitus...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28077734/intake-of-up-to-3-eggs-per-day-is-associated-with-changes-in-hdl-function-and-increased-plasma-antioxidants-in-healthy-young-adults
#14
Diana M DiMarco, Gregory H Norris, Courtney L Millar, Christopher N Blesso, Maria Luz Fernandez
BACKGROUND: HDL function may be more important than HDL concentration in determining risk for cardiovascular disease. In addition, HDL is a carrier of carotenoids and antioxidant enzymes, which protect HDL and LDL particles against oxidation. OBJECTIVE: The goal of this study was to determine the impact of consuming 0-3 eggs/d on LDL and HDL particle size, HDL function, and plasma antioxidants in a young, healthy population. METHODS: Thirty-eight healthy men and women [age 18-30 y, body mass index (in kg/m(2)) 18...
January 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28077192/dietary-probiotic-supplementation-improves-growth-and-the-intestinal-morphology-of-nile-tilapia
#15
M A Ramos, S Batista, M A Pires, A P Silva, L F Pereira, M J Saavedra, R O A Ozório, P Rema
Probiotic administration can be a nutritional strategy to improve the immune response and growth performance of fish. The current study aimed to evaluate the effects of a probiotic blend (Bacillus sp., Pediococcus sp., Enterococcus sp., Lactobacillus sp.) as a dietary supplement on growth performance, feed utilization, innate immune and oxidative stress responses and intestinal morphology in juvenile Nile tilapia (Oreochromis niloticus). The probiotic was incorporated into a basal diet at three concentrations: 0 g/kg (A0: control), 3 g/kg (A1: 1...
January 12, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28076832/dietary-supplementation-of-grape-seed-and-skin-flour-mitigates-brain-oxidative-damage-induced-by-a-high-fat-diet-in-rat-gender-dependency
#16
Kamel Charradi, Mohamed Mahmoudi, Takwa Bedhiafi, Safwen Kadri, Salem Elkahoui, Ferid Limam, Ezzedine Aouani
It is unknown whether gender has an impact on brain injury in obesity, and, if so, whether treatment with grape seed and skin flour could exert a protective effect. Both male and female rats were fed a standard diet (SD) or a high fat diet (HFD) during eight weeks and treated with high dosage grape seed and skin flour (GSSF). Fat-induced oxidative stress was evaluated into the brain with a special emphasis on transition metals determination. HFD induced male-cholesterol overload (+78.12%) and an oxidative stress status characterized by increased lipoperoxidation (+68...
January 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076831/dosing-time-dependent-oxidative-effects-of-an-immunosuppressive-drug-mycophenolate-mofetil-on-rat-kidneys
#17
Ichrak Dridi, Wafa Ben-Cherif, Hassiba Chahdoura, Zohra Haouas, Mossadok Ben-Attia, Karim Aouam, Alain Reinberg, Naceur A Boughattas
This study investigates whether the toxicity in kidneys as well as oxidative stress varied according to the dosing time of an immunosuppressive agent "mycophenolate mofetil (MMF)" in Wistar Rat. 300mg/kg of MMF was injected by intraperitonal at four different circadian stages (1, 7, 13 and 19h after light onset, HALO). Rats were sacrificed after 3days, and the kidneys were removed for determination of oxidative stress and histological analysis. Biochemical variable (creatinine, urea) was performed. Statistical analysis showed that MMF administration at 7 HALO produced a renal toxicity assessed by the significant increase in both blood creatinine and urea and antioxidant activity assessed by malondialdehyde and protein carbonyl levels indicating an induction of lipid peroxidation in oxidative damage...
January 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076691/removal-of-copper-from-aqueous-solutions-by-rhizofiltration-using-genetically-modified-hairy-roots-expressing-a-bacterial-cu-binding-protein
#18
Patricia Pérez-Palacios, Elizabeth Agostini, Sabrina G Ibáñez, Melina A Talano, Ignacio D Rodríguez-Llorente, Miguel A Caviedes, Eloísa Pajuelo
The aim of this work was developing a biotechnological tool to hyperaccumulate high copper (Cu) concentrations from wastewaters. Transgenic tobacco hairy roots were obtained by expressing, either the wild type version of the gene copC from Pseudomonas fluorescens in the cytoplasm of plant cells (CuHR), or a modified version targeted to the vacuole (CuHR-V). Control hairy roots transformed with the empty vector (HR) were also generated. The roots were incubated in the presence of solutions containing Cu (from 1 to 50 mM)...
January 11, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28076619/oxidative-stress-in-human-aorta-of-patients-with-advanced-aortoiliac-occlusive-disease
#19
Márcio Luís Lucas, Cristina Campos Carraro, Adriane Belló-Klein, Antonio Nocchi Kalil, Newton Aerts
Introduction: Oxidative stress seems to be a role in the atherosclerosis process, but research in human beings is scarce. Objective: To evaluate the role of oxidative stress on human aortas of patients submitted to surgical treatment for advanced aortoiliac occlusive disease. Methods: Twenty-six patients were divided into three groups: control group (n=10) formed by cadaveric organ donors; severe aortoiliac stenosis group (patients with severe aortoiliac stenosis; n=9); and total aortoiliac occlusion group (patients with chronic total aortoiliac occlusion; n=7)...
November 2016: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28076505/therapeutic-effect-of-low-molecular-weight-chitosan-containing-sepia-ink-on-ethanol-induced-gastric-ulcer-in-rats
#20
Wei Zhang, Kang Liu, Lei Li, Yingxin Li, Xianxian Sui, Yinzhu Rao, Jiahao Wu, Qiuping Wu
PURPOSE: To evaluate the role of low molecular chitosan containing sepia ink (LMCS) in ethanol-induced (5 ml/kg) gastric ulcer in rats. METHODS: Animals were divided into four groups (n = 12): normal group (Normal), negative control group (Con), experiment group (LMCS) and positive control Omeprazole group (OMZ). Gastric empty rate was detected in the first 7 days. Rats were sacrificed at 7, 14 and 21 day for histology and ELISA detections. RESULTS: Gastric empty was no significant differences among the groups (P > 0...
December 2016: Acta Cirúrgica Brasileira
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