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https://www.readbyqxmd.com/read/27916280/novel-targeted-therapies-for-inflammatory-bowel-disease
#1
REVIEW
Mehmet Coskun, Severine Vermeire, Ole Haagen Nielsen
Our growing understanding of the immunopathogenesis of inflammatory bowel disease (IBD) has opened new avenues for developing targeted therapies. These advances in treatment options targeting different mechanisms of action offer new hope for personalized management. In this review we highlight emerging novel and easily administered therapeutics that may be viable candidates for the management of IBD, such as antibodies against interleukin 6 (IL-6) and IL-12/23, small molecules including Janus kinase inhibitors, antisense oligonucleotide against SMAD7 mRNA, and inhibitors of leukocyte trafficking to intestinal sites of inflammation (e...
December 1, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27824335/oxidative-insult-can-induce-malaria-protective-trait-of-sickle-and-fetal-erythrocytes
#2
Marek Cyrklaff, Sirikamol Srismith, Britta Nyboer, Kvetoslava Burda, Angelika Hoffmann, Felix Lasitschka, Sophie Adjalley, Cyrille Bisseye, Jacques Simpore, Ann-Kristin Mueller, Cecilia P Sanchez, Friedrich Frischknecht, Michael Lanzer
Plasmodium falciparum infections can cause severe malaria, but not every infected person develops life-threatening complications. In particular, carriers of the structural haemoglobinopathies S and C and infants are protected from severe disease. Protection is associated with impaired parasite-induced host actin reorganization, required for vesicular trafficking of parasite-encoded adhesins, and reduced cytoadherence of parasitized erythrocytes in the microvasculature. Here we show that aberrant host actin remodelling and the ensuing reduced cytoadherence result from a redox imbalance inherent to haemoglobinopathic and fetal erythrocytes...
November 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27781009/human-trafficking-identification-and-service-provision-in-the-medical-and-social-service-sectors
#3
Corinne Schwarz, Erik Unruh, Katie Cronin, Sarah Evans-Simpson, Hannah Britton, Megha Ramaswamy
The medical sector presents a unique opportunity for identification and service to victims of human trafficking. In this article, we describe local and site-specific efforts to develop an intervention tool to be used in an urban hospital's emergency department in the midwestern United States. In the development of our tool, we focused on both identification and intervention to assist trafficked persons, through a largely collaborative process in which we engaged local stakeholders for developing site-specific points of intervention...
June 2016: Health and Human Rights
https://www.readbyqxmd.com/read/27720629/-living-kidney-donation
#4
M-O Timsit, F Kleinclauss, M F Mamzer Bruneel, R Thuret
OBJECTIVES: To review ethical, legal and technical aspects of living kidney donor surgery. MATERIAL AND METHODS: An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords: Donor nephrectomy; Kidney paired donation; Kidney transplantation; Laparoscopic nephrectomy; Living donor; Organs trafficking; Robotic assisted nephrectomy; Vaginal extraction...
October 6, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27692897/optogenetic-immunomodulation-shedding-light-on-antitumor-immunity
#5
Peng Tan, Lian He, Gang Han, Yubin Zhou
Microbial opsin-based optogenetic tools have been transformative for neuroscience. To extend optogenetic approaches to the immune system to remotely control immune responses with superior spatiotemporal precision, pioneering tools have recently been crafted to modulate lymphocyte trafficking, inflammasome activation, dendritic cell (DC) maturation, and antitumor immunity through the photoactivation of engineered chemokine receptors and calcium release-activated calcium channels. We highlight herein some conceptual design strategies for installing light sensitivities into the immune signaling network and, in parallel, we propose potential solutions for in vivo optogenetic applications in living organisms with near-infrared light-responsive upconversion nanomaterials...
September 28, 2016: Trends in Biotechnology
https://www.readbyqxmd.com/read/27686675/progressive-multifocal-leukoencephalopathy-in-hiv-uninfected-individuals
#6
REVIEW
Deanna Saylor, Arun Venkatesan
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by the human neurotropic polyomavirus JC (JCV). The disease occurs virtually exclusively in immunocompromised individuals, and, prior to the introduction of antiretroviral therapy, was seen most commonly in the setting of HIV/AIDS. More recently, however, the incidence of PML in HIV-uninfected persons has increased with broader use of immunosuppressive and immunomodulatory medications utilized in a variety of systemic and neurologic autoimmune disorders...
November 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27555599/tackling-trafficking-by-targeting-sex-buyers-can-it-work
#7
Johanna Niemi, Jussi Aaltonen
The European legal instruments on human trafficking encourage states to tackle the demand for services of trafficked persons, for example, by making the use of services of a trafficked person a criminal offense. In Finland, buying sex from a trafficked person is a criminal offense. This article reports the results of an evaluation of the Finnish law and shows that the implementation has been inefficient. The authors argue that with an amendment of the law, the implementation could be improved but a truly efficient policy would require a total ban of sex purchase along the lines of the Swedish model...
August 23, 2016: Violence Against Women
https://www.readbyqxmd.com/read/27548692/emerging-therapies-for-inflammatory-bowel-diseases
#8
Reena Khanna, Brian G Feagan
BACKGROUND: The past decade has seen important advances in the management of chronic inflammatory bowel diseases (IBD), consisting of Crohn's disease (CD) and ulcerative colitis. The development of TNF antagonists, the recognition of interrupting lymphocyte trafficking as an effective treatment strategy, confirmation of the value of combination therapy, and the need, particularly in CD, for the treatment of high-risk patients early in the disease course are all fundamental concepts upon which the next generation of IBD treatment algorithms will be built...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27537695/human-trafficking-the-role-of-medicine-in-interrupting-the-cycle-of-abuse-and-violence
#9
Wendy Macias-Konstantopoulos
Human trafficking, a form of modern slavery, is an egregious violation of human rights with profound personal and public health implications. It includes forced labor and sexual exploitation of both U.S. and non-U.S. citizens and has been reported in all 50 states. Victims of human trafficking are currently among the most abused and disenfranchised persons in society, and they face a wide range of negative health outcomes resulting from their subjugation and exploitation. Medicine has an important role to play in mitigating the devastating effects of human trafficking on individuals and society...
October 18, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27500254/the-hague-recommendations-improving-nonlegislative-responses-to-trafficking-in-human-beings-for-the-purpose-of-organ-removal
#10
Frederike Ambagtsheer, Willem Weimar
Over the years, the trade in human organs has become an object of international concern. Since the 1980s, antiorgan trade initiatives have mainly involved the strengthening of legislative responses. Little attention however is given to nonlegislative responses by law enforcement authorities. The HOTT project is a European Union-funded research project titled "trafficking in human beings for the purpose of organ removal." Its objectives are to increase knowledge, raise awareness, and improve the nonlegislative response to the crime...
February 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27500250/stimulating-and-enhancing-partnerships-between-transplant-professionals-and-law-enforcement-recommendations
#11
Alexander Morgan Capron, Elmi Muller, Gilad Erlich, Manoj John, Ric Esther Bienstock, Mark McCarren, Robin Palmer, Nancy Scheper-Hughes, Dina Siegel, Jordan Yankov
To help combat trafficking in human beings for organ removal (THBOR), transplant professionals need to do more than carry out careful, multidisciplinary screening of potential living donors; they also need to communicate and collaborate with law enforcement professionals. This will involve transplant professionals educating investigators and prosecutors about transplant practices and in turn learning about THBOR and how it is prosecuted. Cases of illegal organ transplantation need to be detected at different levels...
February 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27500249/indicators-to-identify-trafficking-in-human-beings-for-the-purpose-of-organ-removal
#12
Jessica de Jong, Frederike Ambagtsheer
This article presents indicators to support transplant professionals, judicial and law enforcement authorities and victim support workers with the identification of trafficking in persons for the purpose of organ removal. It outlines the legal and illegal service providers that facilitate trafficking in human beings for the purpose of organ removal and guides the reader through the following criminal process: recruitment, transport, entrance, documents, housing, transplant, aftercare, and finance. Identification of illegal transplant activities by transplant professionals can support police and judiciary with the investigation, disruption, and prosecuting of trafficking networks...
February 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27355820/statement-of-the-declaration-of-istanbul-custodian-group-regarding-payments-to-families-of-deceased-organ-donors
#13
Alexander Morgan Capron, Francis L Delmonico, Beatriz Dominguez-Gil, Dominique Elizabeth Martin, Gabriel M Danovitch, Jeremy Chapman
Governmental and private programs that pay next of kin who give permission for the removal of their deceased relative's organs for transplantation exist in a number of countries. Such payments, which may be given to the relatives or paid directly for funeral expenses or hospital bills unrelated to being a donor, aim to increase the rate of donation. The Declaration of Istanbul Custodian Group-in alignment with the World Health Organization Guiding Principles and the Council of Europe Convention Against Trafficking in Human Organs-has adopted a new policy statement opposing such practices...
September 2016: Transplantation
https://www.readbyqxmd.com/read/27217832/versatile-nanosystem-based-cancer-theranostics-design-inspiration-and-predetermined-routing
#14
REVIEW
Yaw Opoku-Damoah, Ruoning Wang, Jianping Zhou, Yang Ding
The relevance of personalized medicine, aimed at a more individualized drug therapy, has inspired research into nano-based concerted diagnosis and therapeutics (theranostics). As the intention is to "kill two birds with one stone", scientists have already described the emerging concept as a treasured tailor for the future of cancer therapy, wherein the main idea is to design "smart" nanosystems to concurrently discharge both therapeutic and diagnostic roles. These nanosystems are expected to offer a relatively clearer view of the ingenious cellular trafficking pathway, in-situ diagnosis, and therapeutic efficacy...
2016: Theranostics
https://www.readbyqxmd.com/read/27189733/trafficking-and-health-a-systematic-review-of-research-methods
#15
Abby C Cannon, Jennet Arcara, Laurie M Graham, Rebecca J Macy
Trafficking in persons (TIP) is a human rights violation with serious public health consequences. Unfortunately, assessing TIP and its health sequelae rigorously and reliably is challenging due to TIP's clandestine nature, variation in definitions of TIP, and the need to use research methods that ensure studies are ethical and feasible. To help guide practice, policy, and research to assess TIP and health, we undertook a systematic literature review of 70 peer-reviewed, published articles to (a) identify TIP and health research methods being used, (b) determine what we can learn about TIP and health from these varied methodologies, and (c) determine the gaps that exist in health-focused TIP research...
May 17, 2016: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/27087386/prescription-monitoring-program-trends-among-individuals-arrested-in-maine-for-trafficking-prescription-drugs-in-2014
#16
Kenneth McCall, Stephanie D Nichols, Christina Holt, Leslie Ochs, Gary Cattabriga, Chunhao Tu
OBJECTIVE: To evaluate controlled substance prescribing trends available in the Maine Prescription Monitoring Program (PMP) among individuals arrested for prescription drug "trafficking." The demographic characteristics of the individuals who had matching prescription records in the PMP within 90 days of the arrest were identified. STUDY DESIGN: A population-based, retrospective cohort study using data from the Maine Diversion Alert Program (DAP) and the Maine PMP...
June 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27068976/dopamine-d4-receptor-ubiquitination
#17
REVIEW
Kamila Skieterska, Pieter Rondou, Kathleen Van Craenenbroeck
Ubiquitination is a post-translational modification that targets proteins for degradation but can also regulate other cellular processes such as endocytosis, trafficking and DNA repair. We investigate ubiquitination of the dopamine D4receptor (D4R) which belongs to the superfamily of G protein-coupled receptors (GPCR). Several polymorphic variants of the D4R exist, which differ in the number of 16-amino acid repeats in the third intracellular loop (IC3) of the receptor. The functional role of this polymorphic region is not known but persons with the seven-repeat allele show a predisposition to develop attention deficit hyperactivity disorder (ADHD)...
April 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/26911863/a-novel-follicle-stimulating-hormone-receptor-mutation-causing-primary-ovarian-failure-a-fertility-application-of-whole-exome-sequencing
#18
Matthew S Bramble, Ellen H Goldstein, Allen Lipson, Tuck Ngun, Ascia Eskin, Jason E Gosschalk, Lara Roach, Neerja Vashist, Hayk Barseghyan, Eric Lee, Valerie A Arboleda, Daniel Vaiman, Zafer Yuksel, Marc Fellous, Eric Vilain
STUDY QUESTION: Can whole exome sequencing (WES) and in vitro validation studies be used to find the causative genetic etiology in a patient with primary ovarian failure and infertility? SUMMARY ANSWER: A novel follicle-stimulating hormone receptor (FSHR) mutation was found by WES and shown, via in vitro flow cytometry studies, to affect membrane trafficking. WHAT IS KNOWN ALREADY: WES may diagnose up to 25-35% of patients with suspected disorders of sex development (DSD)...
April 2016: Human Reproduction
https://www.readbyqxmd.com/read/26910264/trafficking-in-persons-q-a-with-dr-donna-sabella
#19
EDITORIAL
Cindy Peternelj-Taylor
No abstract text is available yet for this article.
January 2016: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/26894479/-treatment-of-cystic-fibrosis-with-cftr-modulators
#20
B Tümmler
Personalized medicine promises that medical decisions, practices and products are tailored to the individual patient. Cystic fibrosis, an inherited disorder of chloride and bicarbonate transport in exocrine glands, is the first successful example of customized drug development for mutation-specific therapy. There are two classes of CFTR modulators: potentiators that increase the activity of CFTR at the cell surface, and correctors that either promote the read-through of nonsense mutations or facilitate the translation, folding, maturation and trafficking of mutant CFTR to the cell surface...
May 2016: Pneumologie
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