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trafficking in persons

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https://www.readbyqxmd.com/read/29566751/engineering-a-multicellular-vascular-niche-to-model-hematopoietic-cell-trafficking
#1
Surya S Kotha, Brian J Hayes, Kiet T Phong, Meredith A Redd, Karol Bomsztyk, Aravind Ramakrishnan, Beverly Torok-Storb, Ying Zheng
BACKGROUND: The marrow microenvironment and vasculature plays a critical role in regulating hematopoietic cell recruitment, residence, and maturation. Extensive in vitro and in vivo studies have aimed to understand the marrow cell types that contribute to hematopoiesis and the stem cell environment. Nonetheless, in vitro models are limited by a lack of complex multicellular interactions, and cellular interactions are not easily manipulated in vivo. Here, we develop an engineered human vascular marrow niche to examine the three-dimensional cell interactions that direct hematopoietic cell trafficking...
March 23, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29499438/necroptotic-cancer-cells-mimicry-nanovaccine-boosts-anti-tumor-immunity-with-tailored-immune-stimulatory-modality
#2
Ting Kang, Yukun Huang, Qianqian Zhu, Hao Cheng, Yuanyuan Pei, Jingxian Feng, Minjun Xu, Gan Jiang, Qingxiang Song, Tianze Jiang, Hongzhuan Chen, Xiaoling Gao, Jun Chen
Recent breakthroughs in cancer immunotherapy offer new paradigm-shifting therapeutic options for combating cancer. Personalized therapeutic anti-cancer vaccines training T cells to directly fight against tumor cells endogenously offer tremendous benefits in working synergistically with immune checkpoint inhibitors. Biomimetic nanotechnology offers a versatile platform to boost anticancer immunity by efficiently co-delivering optimized immunogenic antigen materials and adjuvants to antigen presenting cells (APC)...
February 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/29470968/multiple-sclerosis-mechanisms-and-immunotherapy
#3
REVIEW
Clare Baecher-Allan, Belinda J Kaskow, Howard L Weiner
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. It features three clinical stages: a pre-clinical stage detectable only by MRI; a relapsing-remitting (RRMS) stage characterized by episodes of neurologic dysfunction followed by resolution; and a progressive stage, which usually evolves from the relapsing stage. Advances in our understanding of the immune mechanisms that contribute to MS have led to more than ten FDA-approved immunotherapeutic drugs that target effector T cells, regulatory cells, B cells, and cell trafficking into the nervous system...
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29459380/convergent-molecular-defects-underpin-diverse-neurodegenerative-diseases
#4
REVIEW
George K Tofaris, Noel J Buckley
In our ageing population, neurodegenerative disorders carry an enormous personal, societal and economic burden. Although neurodegenerative diseases are often thought of as clinicopathological entities, increasing evidence suggests a considerable overlap in the molecular underpinnings of their pathogenesis. Such overlapping biological processes include the handling of misfolded proteins, defective organelle trafficking, RNA processing, synaptic health and neuroinflammation. Collectively but in different proportions, these biological processes in neurons or non-neuronal cells lead to regionally distinct patterns of neuronal vulnerability and progression of pathology that could explain the disease symptomology...
February 19, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29412070/implications-of-human-trafficking-in-asia-a-scoping-review-of-aftercare-initiatives-centered-on-economic-development
#5
Meghan A Camp, John R Barner, David Okech
The trafficking of persons is one of the most egregious violations of human rights in modern society. Given the disproportionate effects across demographic categories of age and gender, as well as concentrated impacts within the developing world, there is a strong need for research and literature on program effectiveness and appropriate aftercare efforts for those persons whose lives and livelihoods have been impacted by trafficking. The purpose of this article is to provide a scoping review of what is known about effectively helping survivors of human trafficking experiencing lack of economic opportunity and the implications for practice and future research regarding the absence of literature...
February 7, 2018: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/29383027/inflammatory-bowel-disease-towards-a-personalized-medicine
#6
REVIEW
Mathurin Flamant, Xavier Roblin
The management of inflammatory bowel disease (IBD) has been transformed over the last two decades by the arrival of tumor necrosis factor (TNF) antagonist agents. Recently, alternative drugs have been approved, directed at leukocyte-trafficking molecules (vedolizumab) or other inflammatory cytokines (ustekinumab). New therapeutics are currently being developed in IBD and represent promising targets as they involve other mechanisms of action (JAK molecules, Smad 7 antisense oligonucleotide etc.). Beyond TNF antagonist agents, these alternative drugs are needed for early-stage treatment of patients with aggressive IBD or when the disease is resistant to conventional therapy...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29377354/redirecting-adult-mesenchymal-stromal-cells-to-the-brain-a-new-approach-for-treating-cns-autoimmunity-and-neuroinflammation
#7
REVIEW
Jasmine J Wilson, Kerrie Foyle, Jade Foeng, Todd Norton, Duncan R McKenzie, Natalie Payne, Claude C Bernard, Shaun R McColl, Iain Comerford
Mesenchymal stromal cells or stem cells (MSCs) have been shown to participate in tissue repair and are immunomodulatory in neuropathological settings. Given this, their potential use in developing a new generation of personalized therapies for autoimmune and inflammatory diseases of the central nervous system (CNS) will be explored. To effectively exert these effector functions, MSCs must first gain entry into damaged neural tissues, a process that has been demonstrated to be a limiting factor in their therapeutic efficacy...
January 29, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29327391/molecular-phenotype-of-slc4a11-missense-mutants-setting-the-stage-for-personalized-medicine-in-corneal-dystrophies
#8
Kumari Alka, Joseph R Casey
SLC4A11 mutations cause cases of congenital hereditary endothelial dystrophy (CHED), Harboyan syndrome (HS), and Fuchs endothelial corneal dystrophy (FECD). Defective water reabsorption from corneal stroma by corneal endothelial cells (CECs) leads to these corneal dystrophies. SLC4A11, in the CEC basolateral membrane, facilitates transmembrane movement of H2 O, NH3 , and H+ -equivalents. Some SLC4A11 disease mutants have impaired folding, leading to a failure to move to the cell surface, which in some cases can be corrected by the drug, glafenine...
January 11, 2018: Human Mutation
https://www.readbyqxmd.com/read/29320614/deep-tumor-penetrating-bioparticulates-inspired-burst-intracellular-drug-release-for-precision-chemo-phototherapy
#9
Ruoning Wang, Yue Han, Bo Sun, Ziqiang Zhao, Yaw Opoku-Damoah, Hao Cheng, Huaqing Zhang, Jianping Zhou, Yang Ding
The relevance of personalized medicine has inspired research for individually concerted diagnosis and therapy. Numerous efforts are devoted to designing drug particulates with capabilities of tumor penetrating and subcellular trafficking to concurrently discharge theranostics in response to multistimulations. In this study, a bioinspired particulate, formulated with whole components of native high-density lipoproteins (HDLs) and decorated with the tumor-penetrating peptide iRGD, is proposed to promote tumor penetration of HDLs (pHDLs) together with payloads...
March 2018: Small
https://www.readbyqxmd.com/read/29299208/the-relationship-between-personality-disorders-and-the-type-of-crime-committed-and-substance-used-among-prisoners
#10
Shahin Fakhrzadegan, Hossein Gholami-Doon, Bagher Shamloo, Solmaz Shokouhi-Moqhaddam
Background: Prisoners are a vulnerable group within societies, and also threaten society due to their dangerous behavior. The objective of the present study was to evaluate the relationship between prisoners' personality disorders and their crime and substance use. Methods: This was a descriptive-correlational study. The statistical population consisted of all prisoners of Kerman, Iran. Through stratified random sampling, 228 prisoners (114 women and 114 men) were selected as the study subjects...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29294728/trafficking-experiences-and-psychosocial-features-of-domestic-minor-sex-trafficking-victims
#11
Jessica L Moore, Christopher Houck, Priyadarshini Hirway, Christine E Barron, Amy P Goldberg
Domestic minor sex trafficking (DMST) is an increasingly recognized traumatic crime premised upon the control, abuse, and exploitation of youth. By definition, DMST is the "recruitment, harboring, transportation, provision, or obtaining of a person for the purpose of a commercial sex act" within domestic borders, in which the person is a U.S. citizen or lawful permanent resident under the age of 18 years. The present study described the demographics, psychosocial features, and trafficking experiences (e...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29242522/amyloid-%C3%AE-and-tau-complexity-towards-improved-biomarkers-and-targeted-therapies
#12
REVIEW
Juan Carlos Polanco, Chuanzhou Li, Liviu-Gabriel Bodea, Ramon Martinez-Marmol, Frederic A Meunier, Jürgen Götz
Most neurodegenerative diseases are proteinopathies, which are characterized by the aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to aggregate, particularly when cellular clearance systems start to fail in the context of ageing, only a few form fibrillar aggregates. In Alzheimer disease, the peptide amyloid-β (Aβ) and the protein tau aggregate to form plaques and tangles, respectively, which comprise the histopathological hallmarks of this disease. This Review discusses the complexity of Aβ biogenesis, trafficking, post-translational modifications and aggregation states...
January 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29223888/neighborhood-crime-undermines-parenting-violence-in-the-vicinity-of-households-as-a-predictor-of-aggressive-discipline
#13
Jorge Cuartas
Child discipline is a central component of parent-child interactions. Evidence suggests corporal discipline impairs children's physical, cognitive, and socioemotional development and compromises their future chances, especially since it is more frequently used against at-risk children. Using geocoded data for 1209 children under the age of five and their mothers, this study analyses the relation between the occurrence of crimes in close proximity to households in four major urban municipalities of Colombia and a particularly violent corporal discipline practice: hitting children with objects...
February 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29196472/first-person-ana-nascimento
#14
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Ana Nascimento is the first author on 'KIF13A mediates trafficking of influenza A virus ribonucleoproteins', published in Journal of Cell Science. Ana conducted the work in this article in Maria João Amorim's lab at the Instituto Gulbenkian de Ciência, Portugal. She is now a PhD student in the lab of Beate Sodeik at the Institute of Virology at Hannover Medical School, investigating host-pathogen interactions, particularly involving viruses...
December 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29166394/maternity-care-for-trafficked-women-survivor-experiences-and-clinicians-perspectives-in-the-united-kingdom-s-national-health-service
#15
Debra Bick, Louise M Howard, Sian Oram, Cathy Zimmerman
BACKGROUND: Although trafficked women and adolescents are at risk of unprotected or forced sex, there is little research on maternity care among trafficking survivors. We explored health care needs, service use and challenges among women who became pregnant while in the trafficking situation in the United Kingdom (UK) and clinicians' perspectives of maternity care for trafficked persons. METHODS: Cross-sectional survey and qualitative interviews with trafficking survivors recruited from statutory and voluntary sector organisations in England and qualitative interviews with maternity clinicians and family doctors undertaken to offer further insight into experiences reported by these women...
2017: PloS One
https://www.readbyqxmd.com/read/29095121/survivors-voices-complex-needs-of-sex-trafficking-survivors-in-the-midwest
#16
Sriyani Tidball, Shireen S Rajaram
Human trafficking is a serious public health issue and has long-term physical, mental, social, and economic consequences for survivors, their families, and communities. The Victims of Trafficking and Violence Protection Act of 2000 defines sex trafficking as a commercial sex act that is induced by force, fraud or coercion, or when a commercial sex act involves a person below 18 years of age. There is inadequate research from the perspectives of survivors. The purpose of this study was to gather data from survivors on their complex needs...
November 2, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/29027216/the-long-pentraxin-ptx3-a-prototypical-sensor-of-tissue-injury-and-a-regulator-of-homeostasis
#17
REVIEW
Marco Erreni, Angelo A Manfredi, Cecilia Garlanda, Alberto Mantovani, Patrizia Rovere-Querini
Tissue damage frequently occurs. The immune system senses it and enforces homeostatic responses that lead to regeneration and repair. The synthesis of acute phase molecules is emerging as a crucial event in this program. The prototypic long pentraxin PTX3 orchestrates the recruitment of leukocytes, stabilizes the provisional matrix in order to facilitate leukocyte and stem progenitor cells trafficking, promotes swift and safe clearance of dying cells and of autoantigens, limiting autoimmunity and protecting the vasculature...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29024922/isolation-and-whole-genome-analysis-of-endospore-forming-bacteria-from-heroin
#18
Jörn Kalinowski, Björn Ahrens, Arwa Al-Dilaimi, Anika Winkler, Daniel Wibberg, Uwe Schleenbecker, Christian Rückert, Roman Wölfel, Gregor Grass
Infections caused by endospore-forming bacteria have been associated with severe illness and death among persons who inject drugs. Analysis of the bacteria residing in heroin has thus been biased towards species that affect human health. Similarly, exploration of the bacterial diversity of seized street market heroin correlated with the skin microflora of recreational heroin users insofar as different Staphylococus spp. or typical environmental endospore formers including Bacillus cereus and other Bacilli outside the B...
January 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28966163/first-person-brandy-hyndman-and-mathieu-crupi
#19
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Brandy Hyndman and Mathieu Crupi are co-first authors on 'Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization', published in Journal of Cell Science. Brandy is a Research Associate and Mathieu is a PhD student, both in the lab of Dr Lois Mulligan at the Queen's University Cancer Research Institute in Kingston, ON, Canada, investigating the ubiquitylation and trafficking of RET receptor tyrosine kinase isoforms...
October 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28945674/trafficking-and-trauma-insight-and-advice-for-the-healthcare-system-from-sex-trafficked-women-incarcerated-on-rikers-island
#20
Anita Ravi, Megan R Pfeiffer, Zachary Rosner, Judy A Shea
BACKGROUND: Sex-trafficked persons experience significant trauma while exploited, resulting in complex health issues and barriers to health care. Incorporating survivor perspectives is critical in optimizing health care delivery for this population. OBJECTIVES: We interviewed sex-trafficking survivors regarding their experiences with trauma while being trafficked and elicited advice about health care delivery. RESEARCH DESIGN: Qualitative interviews were conducted in New York City's Rikers Island jail from July to September 2015...
December 2017: Medical Care
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