Read by QxMD icon Read


Ana Galán-Cobo, Elena Arellano-Orden, Rocío Sánchez Silva, José Luis López-Campos, César Gutiérrez Rivera, Lourdes Gómez Izquierdo, Nela Suárez-Luna, María Molina-Molina, José A Rodríguez Portal, Miriam Echevarría
Activation of the epithelial-mesenchymal transition process (EMT) by which alveolar cells in human lung tissue undergo differentiation giving rise to a mesenchymal phenotype (fibroblast/miofibroblasts) has been well recognized as a key element in the origin of idiopathic pulmonary fibrosis (IPF). Here we analyzed expression of AQP1 in lung biopsies of patients diagnosed with IPF, and compared it to biopsies derived from patients with diverse lung pneumonies, such as hypersensitivity pneumonitis, sarcoidosis or normal lungs...
2018: Frontiers in Molecular Biosciences
Jyotiranjan Champatiray, Jyotiranjan Satapathy, Baikunthanath Kashyap, Dipankar Mondal
Introduction: Pneumonia is a major cause of mortality under five-year-old children. In spite of recent advances in management, there is paucity of data on clinical, aetiological profile of severe and very severe pneumonia among under five-year-old children in developing countries. Aim: To determine the clinico-aetiological factors of severe and very severe pneumonia and its outcome in children aged two -months to five-years in a tertiary health care centre in Odisha, India...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Bahubali M Chougala, S Samundeeswari, Megharaja Holiyachi, Nirmala S Naik, Lokesh A Shastri, Suneel Dodamani, Sunil Jalalpure, Sheshagiri R Dixit, Shrinivas D Joshi, Vinay A Sunagar
A green and efficient protocol has been developed and a series of coumarin based pyrano[3,2-c]chromene derivatives (2) have been synthesized using multi-component reaction (MCR) approach. Unexpected 3-coumarinyl-3-pyrazolylpropanoic acids (3) and C4 -C4 chromenes (5) have been isolated instead of expected product 4 by the reaction of compound (2) in formic acid at 90 °C for about 4-5 h and at 130 °C for about 8-10 h respectively. Further, C4 -C4 chromenes (5) formation was confirmed by intramolecular cyclization of compounds (3)...
January 1, 2018: European Journal of Medicinal Chemistry
Andrés Augusto Arias, Carlos M Perez-Velez, Julio César Orrego, Marcela Moncada-Velez, Jessica Lineth Rojas, Alejandra Wilches, Andrea Restrepo, Mónica Trujillo, Carlos Garcés, Catalina Arango-Ferreira, Natalia González, Carmen Oleaga-Quintas, Diana Fernández, Johana Marcela Isaza-Correa, Diego Eduardo Gongóra, Daniel Gonzalez-Loaiza, Juan Esteban Sierra, Jean Laurent Casanova, Jacinta Bustamante, José Luis Franco
PURPOSE: Mendelian susceptibility to mycobacterial disease is a rare clinical condition characterized by a predisposition to infectious diseases caused by poorly virulent mycobacteria. Other infections such as salmonellosis and candidiasis are also reported. The purpose of this article is to describe a young boy affected with various infectious diseases caused by Mycobacterium tuberculosis complex, Salmonella sp, Klebsiella pneumonie, Citrobacter sp., and Candida sp, complicated with severe enteropathy and transient hypogammaglobulinemia...
October 2017: Journal of Clinical Immunology
Rakesh Bhadade, Minal Harde, Rosemarie deSouza, Ashwini More, Ramesh Bharmal
BACKGROUND: Nosocomial pneumonia poses great challenge to an intensivist. Detailed information about hospital-acquired pneumonia (HAP) and ventilator-acquired pneumonia (VAP) is crucial for prevention and optimal management, thus improving quality Intensive Care Unit (ICU) care. Hence, we aimed to study the current trend of nosocomial pneumonia in ICU. MATERIALS AND METHODS: It was a prospective observational cohort study, conducted in the ICU of a tertiary care teaching public hospital over a period of 18 months...
July 2017: Annals of African Medicine
M Beridze, N Khizanishvili, M Mdivani, O Samushia, N Gogokhia
The paper reported the verified case of neuroboreliosis with unusual clinical presentation of Parkinsonism. Study aimed at establishing the significance of a precise differential diagnosis with substantial analysis of the symptoms of several diseases to avoid the false diagnosis and to conduct the opportune and adequate therapeutic management. We described the case of the diagnosed neuroboreliosis with clinical expression of Multiple Sclerosis (MS) and Parkinsonism. A 44 years old man was diagnosed as MS according to the McDonald's Criteria, who within two years developed typical clinical signs of Parkinsonism...
March 2017: Georgian Medical News
Paul Simusika, Allen C Bateman, Andros Theo, Geoffrey Kwenda, Christine Mfula, Edward Chentulo, Mwaka Monze
BACKGROUND: Morbidity and mortality from respiratory infections are higher in resource-limited countries than developed countries, but limited studies have been conducted in resource-limited settings to examine pathogens from patients with acute respiratory infections. Influenza surveillance has been conducted in Zambia since 2008; however, only 4.3% of patients enrolled in 2011-2012 were positive for influenza. Therefore, we examined non-influenza respiratory pathogens in children with severe acute respiratory illness (SARI) in Zambia, to estimate the scope of disease burden and determine commonly-identified respiratory pathogens...
2015: BMC Infectious Diseases
Lawrence Mugisha, Sophie Köndgen, Deogratias Kaddu-Mulindwa, Lynne Gaffikin, Fabian H Leendertz
Information on the chimpanzee nasopharygeal colonization in captive sanctuaries and in the wild is rare. This study was undertaken to establish the nasopharygeal colonization and potential bacterial pathogens in sanctuary chimpanzees as a basis for improving chimpanzee and employee health. Nasopharygeal colonization of 39 healthy chimpanzees were analyzed by microbiological cultivation method and polymerase chain reaction (PCR) targeting the bacterial 16S rRNA gene. We report four major phyla dominated by Proteobacteria (50%), Fermicutes (35...
February 2014: American Journal of Primatology
F Ö Eyüboğlu, E Küpeli, S S Bozbaş, Z E Ozen, E S Akkurt, C Aydoğan, G Ulubay, S Akçay, M Haberal
BACKGROUND: Recipients of solid organ transplants (SOTs) are at higher risk to develop pulmonary infections (PIs) owing to their immunocompromised state. Flexible bronchoscopy (FB) is frequently performed to diagnose nature of these infections. The aim of 12-year review was to evaluate the demographic characteristics of SOT recipients with PIs and to study diagnostic utility of FB in this group of patients. METHODS: Medical records of patients who underwent SOT as well as FB between 2000 and 2012 were retrospectively reviewed...
2013: Transplantation Proceedings
Lais Pinto de Almeida, Fabiana Puerro de Carvalho, Alexandre Gimenes Marques, Andrea Dos Santos Pereira, Renata Puzzo Bortoleto, Marinês Dalla Valle Martino
OBJECTIVE: To evaluate ertapenem disk performance to predict Klebsiella pneumonie carbapenemase production by Gram-negative bacilli. METHODS: All Gram-negative bacilli isolated between January 2010 and June 2011 were tested by disk diffusion (Oxoid™) for sensitivity to ertapenem, meropenem and imipenem. Resistant or intermediate sensitivity strains (diameter < 22 mm for ertapenem) were also tested for the blaKPC gene by polymerase chain reaction. Disk predictive positive value for Klebsiella pneumoniae carbapenemase and specificity were calculated...
October 2012: Einstein
Pornchai Simaroj, Suvicha Kompreyarat, Pitak Santanirand, Kaevalin Lekhanont
OBJECTIVE: To determine the rate of anterior chamber contamination during phacoemulsification after applying 5% povidone-iodine prior to surgery. MATERIAL AND METHOD: One hundred eyes from 100 patients having phacoemulsification cataract surgery by a single surgeon at Ramathibodi Hospital between October 2010 and March 2011 were included in the present study. Povidone-iodine 5% solution eye drops were used in all patients at least three minutes before the operation...
May 2012: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Y-T Lee, S-C Kuo, S-P Yang, Y-T Lin, D-H Chiang, F-C Tseng, T-L Chen, C-P Fung
The phenotypically indistinguishable Acinetobacter baumannii and Acinetobacter nosocomialis have become leading pathogens causing nosocomial pneumonia in critically ill patients. A. baumannii and A. nosocomialis nosocomial pneumonias were grouped as a single clinical entity previously. This study aimed to determine whether they are the same or a different clinical entity. A total of 121 patients with A. baumannii and 131 with A. nosocomialis bacteremic nosocomial pneumonia were included during an 8-year period...
July 2013: Clinical Microbiology and Infection
Cristina Tecu, Maria E Mihai, Viorel I Alexandrescu, Dumitru Orăşanu, Carmen Zapucioiu, Dumitru Matei, M Craiu, Alexis Cochino
UNLABELLED: The objective of this study was to investigate the percent of infections with adenovirus (ADV) in children who had pneumonia, acute bronchiolitis or viral respiratory infections and were admitted to two pediatrics hospitals in Bucharest (Grigore Alexandrescu Hospital and Alfred Rusescu Hospital). MATERIALS AND METHODS: <AbstractText Label="SUBJECTS" NlmCategory="METHODS">70 children aged one month - five years, admitted to the above mentioned pediatrics hospitals in Bucharest, who were negative for the Respiratory Syncytial Virus (RSV) and the human Metapneumovirus (hMPV) by Reverse Transcription -Polymerase Chain Reaction (RT-PCR)...
January 2012: Roumanian Archives of Microbiology and Immunology
Nura Suleiman Gwaram, Hapipah Mohd Ali, Hamid Khaledi, Mahmood Ameen Abdulla, A Hamid A Hadi, Thong Kwai Lin, Chai Lay Ching, Cher Lin Ooi
A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ben Rao, Liao Yuan Zhang, Jian'an Sun, Gang Su, Dongzhi Wei, Ju Chu, Jiawen Zhu, Yaling Shen
Serratia marcescens has been proved to be a potential strain for industrial 2,3-butanediol production for its high yield, productivity, and other advantages. In this study, the genes slaA, slaB, slaC, and slaR were successfully cloned which were further confirmed to be encoding acetolactate decarboxylase, acetolactate synthase, 2,3-butanediol dehydrogenase, and a LysR-like regulator, respectively. Unlike in Klebsiella sp. or Klebsiella pneumonie and Vibrio sp. or Vibrio cholerae, the gene slaC is separated from other genes...
March 2012: Applied Microbiology and Biotechnology
Veljko Flego, Marina Kurpis, Flavija Milevoj-Ribić, Ljiljana Bulat-Kardum, Dubravka Matanić
We present a case of 23-year-old student misdiagnosed for two months. Radiological finding showed a pneumonial infiltrate of left lung lower lobe. Antibiotical therapy was not resulting in a radiological regression. Biopsy of the lung infiltrate by transthoracic computed tomography guided histology needle, showed granulomatous inflammation with necrosis. Bronchial aspirate received by bronchoscopy was positive in culture on Mycobacterium tuberculosis. After 6 months of antituberculotic therapy advance the complete regression of lung infiltrate...
December 2010: Collegium Antropologicum
G Barten, H Schütte, R Bals, M Pletz, G Rohde
Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. It ranks as the fourth leading cause of death in the Western industrialized countries. New insights in the epidemiology and pathogenesis, recent developments in diagnosis and risk-stratification, and current recommendations on prevention and therapy were presented at the symposium "Pneumonie 2010 - State of the Art", held in Kassel, Germany, on the 4. - 5. November 2010. This symposium was organized by the CAPNETZ STIFTUNG...
April 2011: Pneumologie
F Vyhnánek, V Adámková, V Duchác, V Teplan, T Jirásek
INTRODUCTION: Nosocomial, intra-abdominal infections are extremely serious conditions, considering possibilities for their early diagnosis, as well as for their effective therapy. Multiresistant bacteria (Enterobacteriacae producing extended-spectrum beta-lactamases - ESBL Escherichia coli, Klebsiella species, vancomycin-resistant enterococci [VRE], and methicillin-resistant Staphylococcus aureus [MRSA]) are frequently isolated as pathogens of these infections. Tygecycline is among the novel wide- spectrum antibiotics affecting multiresistant bacteria, which are being introduced in clinical practice...
September 2009: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Izabela Szczerba, Katarzyna Gortat, Karol Majewski
The aim of this study was to determine a susceptibility of 223 clinical strains Klebsiella to 11 antimicrobial agents and occurrence ESBL-positive strains. These strains were isolated from clinical specimens during 2006 year. Susceptibility of these strains against antimicrobial agents was determined with disc diffusion method according to CLSI recommendation. None of the analysed strains was resistant to imipenem. The Klebsiella pneumonie strains were most frequently isolated from respiratory tract.
2009: Medycyna Doświadczalna i Mikrobiologia
Pasi Huttunen, Maija Lappalainen, Eeva Salo, Tuula Lönnqvist, Pia Jokela, Timo Hyypiä, Heikki Peltola
AIM: Except bacterial meningitis, the agents causing acute central nervous system (CNS) infections in children are disclosed in only approximately half of the cases, and even less in encephalitis. We studied the potential of modern microbiological assays to improve this poor situation. METHODS: In a prospective study during 3 years, all children attending hospital with suspected CNS infection were examined using a wide collection of microbiological tests using samples from the cerebrospinal fluid, serum, nasal swabs and stool...
August 2009: Acta Paediatrica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"