Read by QxMD icon Read


Alexandra Zvereva, Florian Kamp, Helmut Schlattl, Maria Zankl, Katia Parodi
PURPOSE: Variance-based sensitivity analysis (SA) is described and applied to the radiation dosimetry model proposed by the Committee on Medical Internal Radiation Dose (MIRD) for the organ-level absorbed dose calculations in nuclear medicine. The uncertainties in the dose coefficients thus calculated are also evaluated. METHODS: A Monte Carlo approach was used to compute first-order and total-effect SA indices, which rank the input factors according to their influence on the uncertainty in the output organ doses...
May 17, 2018: Medical Physics
Michael G Lancina, Juan Wang, Geoffrey S Williamson, Hu Yang
In this work, we report synthesis and characterization of DenTimol, a dendrimer-based polymeric timolol analog as glaucoma medication. A timolol precursor (S)-4-[4-(oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine (OTM) was reacted with the heterobifunctional amine polyethylene glycol acetic acid (Amine-PEG-Acetic Acid, Mn=2000 g/mol) via the ring opening reaction of epoxide by an amine to form OTM-PEG conjugate. OTM-PEG was then coupled to ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimer G3 to generate DenTimol using the N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) coupling reaction...
May 16, 2018: Molecular Pharmaceutics
D Marian Szebenyi, Irina Kriksunov, Kevin J Howe, John S Ramsey, David G Hall, Michelle L Heck, Stuart B Krasnoff
The title compound C22 H39 NO9 ·CH3 OH [systematic name: ( S )- N -(( S )-{(2 S ,4 R ,6 R )-6-[( S )-2,3-di-hydroxy-prop-yl]-4-hy-droxy-5,5-di-methyl-tetra-hydro-2 H -pyran-2-yl}(hy-droxy)meth-yl)-2-hy-droxy-2-[(2 R ,5 R ,6 R )-2-meth-oxy-5,6-dimeth-yl-4-methyl-ene-tetra-hydro-2 H -pyran-2-yl]acetamide methanol monosolvate], was isolated from the Asian citrus psyllid, Diaphorina citri Kuwayama, and crystallizes in the space group P 21 . ' Candidatus Profftella armatura' a bacterial endosymbiont of D. citri , biosynthesizes diaphorin, which is a hybrid polyketide-nonribosomal peptide comprising two highly substituted tetra-hydro-pyran rings joined by an N -acyl aminal bridge [Nakabachi et al...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Logesh Mathivathanan, Guang Yang, Fenfei Leng, Raphael G Raptis
Crystal structure determination of doxorubicin nitrate, (DoxH)NO3 , systematic name (7 S ,9 S )-7-{[(2 R ,4 S ,5 S ,6 S )-4-azaniumyl-5-hy-droxy-6-methyl-oxan-2-yl]-oxy}-6,9,11-trihy-droxy-9-(2-hy-droxy-acet-yl)-4-meth-oxy-8,10-di-hydro-7 H -tetra-cen-5,12-dione nitrate, shows two formula units present in the asymmetric unit. In the crystal lattice, hydrogen-bonded pairs of (DoxH+ ) cations and segregation of the aglycone and sugar moieties are observed. Inspection of mol-ecular overlays reveals that the conformation of (DoxH)NO3 resembles that of DNA-inter-calated, but not of protein-docked (DoxH)+ ...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Liping Lu, Tingjie Zhan, Mei Ma, Chao Xu, Jingpeng Wang, Chunlong Zhang, Weiping Liu, Shulin Zhuang
Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as BPA alternatives. The global usage of BPS and its analogues (BPSs) caused the frequent detection of their residues in multiple environmental media. We investigated their potential endocrine disrupting effects toward thyroid hormone receptor (TR) β. The molecular interaction of BPSs toward TRβ ligand binding domain (LBD) was probed by fluorescence spectroscopy and molecular dynamics (MD) simulations. BPSs caused the static fluorescence quenching of TRβ LBD...
May 15, 2018: Environmental Science & Technology
Ryan C Fortenberry, Tarek Trabelsi, Joseph S Francisco
The well-studied hydrogen sulfide molecule is shown here for the first time to form a S-S bond barrierlessly with sulfur atomic cation to produce stable H2 SS+ , a compound for which there is nearly no literature data. Previous work has shown that the reaction of hydrogen sulfide with neutral atomic sulfur will likely only take place at high pressures. Conversely, this work shows that hydrogen sulfide will readily bind with atomic sulfur cation first through the 1 4 A'' state from association of H2 S with S+ (4 S) and then will relax down to the nearly degenerate 1 2 A' or 1 2 A'' states...
May 11, 2018: Journal of Physical Chemistry. A
Vincenzo Zanardo, Francesca Volpe, Matteo Parotto, Lara Giliberti, Alphonse Simbi, Lorenzo Severino, Gianluca Straface
BACKGROUND: The human female's areolar region is the point of arrival of a natural progression from birth to breastfeeding continuum, supported by numerous functional features. AIMS: The aim of this study was to look more closely into the areola' skin chemical signals that are uniquely important for mother-infant chemoemission, chemoreception, and breastfeeding continuum. STUDY DESIGN: A dermatological study of the areolae and corresponding breast quadrants was undertaken on 71 healthy, at-term women...
May 7, 2018: Early Human Development
Yolande T R Proroga, Federico Capuano, Rosanna Capparelli, Stefano Bilei, Mariano Bernardo, Maria Pia Cocco, Rosalba Campagnuolo, Vincenzo Pasquale
Non-typhoidal Salmonella enterica infection is a significant public health problem worldwide. The aim of this study was to characterize Salmonella enterica strains isolated from human specimens in central and southern Italy, for epidemiological studies. One hundred and fifty S. enterica strains were serotyped. Isolates were tested for their antimicrobial susceptibility, by disk diffusion method. The molecular characterizations, based on PCR, were carried out for the detection of invA gene and other virulence elements and phage marker genes...
March 31, 2018: Italian Journal of Food Safety
Hyun-Ji Shim, Won Beom Jung, Felix Schlegel, Joonsung Lee, Sangwoo Kim, Jungryun Lee, Seong-Gi Kim
Mouse fMRI is critically useful to investigate functions of transgenic mouse models. Until now, the somatosensory-evoked responses in anesthetized mice are often widespread and inconsistent across reports. Here, we adopted a ketamine and xylazine mixture for mouse fMRI, which is relatively new anesthetics in fMRI experiments. Forepaw stimulation frequency was optimized using cerebral blood volume (CBV)-weighted optical imaging (n = 11) and blood-oxygenation-level dependent (BOLD) fMRI with a gradient-echo time of 16 ms at 9...
May 3, 2018: NeuroImage
Eunji Lee, Seul-Gi Lee, In-Hyeok Park, Seulgi Kim, Huiyeong Ju, Jong Hwa Jung, Mari Ikeda, Yoichi Habata, Shim Sung Lee
A 20-membered N2 O2 S2 -macrocycle (L1 ) and a 40-membered N4 O4 S4 -macrocycle (L2 ) were employed as a [1:1] and a [2:2] cyclization product, respectively, for the preparation of diverse types of supramolecular complexes including a cascade complex. Six complexes (1-6) of the smaller macrocycle L1 including discrete to continuous forms, mono- to heteronuclear, and endo- to exo- and endo/exocoordination were prepared and their coordination modes were discussed systemically. First, the reaction of L1 with CuI in the presence of trifluoroacetic acid afforded an exocyclic 1-D coordination polymer {[(μ4 -Cu4 I4 )(HL1 )2 ](CF3 COO)2 } n (1)...
May 3, 2018: Inorganic Chemistry
Zhongjie Guan, Peng Wang, Qiuye Li, Guoqiang Li, Jianjun Yang
A zero-dimensional (0D)/two-dimensional (2D) heterojunction has an excellent advantage of boosting the photo-generated carrier separation and obtaining enhanced photocatalytic activities. Here, a ZnIn2S4 nanoparticle/MoS2-RGO nanosheet 0D/2D heterojunction was prepared by a rapid and low temperature hydrothermal method. TEM characterization results reveal that ZnIn2S4 nanoparticles are uniformly dispersed on the surface of MoS2-RGO nanosheets, which can provide abundant active sites and shorten the charge-migration distance, while the MoS2-RGO nanosheet acts as a support to avoid the aggregation of 0D ZnIn2S4 nanoparticles and also serves as a low-cost cocatalyst for effective hydrogen evolution...
May 3, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Felix J Rizzuto, Marion Kieffer, Jonathan R Nitschke
The molecular components of biological systems self-sort in different ways to function cooperatively and to avoid interfering with each other. Understanding the driving forces behind these different sorting modes enables progressively more complex self-assembling synthetic systems to be designed. Here we show that subtle ligand differences engender distinct M6 L4 cage geometries - an S 4 -symmetric scalenohedron, or pseudo-octahedra having T point symmetry. When two different ligands were simultaneously employed during self-assembly, a mixture of homo- and heteroleptic cages was generated...
February 21, 2018: Chemical Science
Eleonora Mastrorilli, Daniele Pietrucci, Lisa Barco, Serena Ammendola, Sara Petrin, Alessandra Longo, Claudio Mantovani, Andrea Battistoni, Antonia Ricci, Alessandro Desideri, Carmen Losasso
Over the past decades, Salmonella 4,[5],12:i:- has rapidly emerged and it is isolated with high frequency in the swine food chain. Although many studies have documented the epidemiological success of this serovar, few investigations have tried to explain this phenomenon from a genetic perspective. Here a comparative whole-genome analysis of 50 epidemiologically unrelated S . 4,[5],12:i:-, isolated in Italy from 2010 to 2016 was performed, characterizing them in terms of genetic elements potentially conferring resistance, tolerance and persistence characteristics...
2018: Frontiers in Microbiology
Yuxue Dai, Xiaodong Zhu, Hao Liu, Yanna Lin, Weiyan Sun, Yuanling Sun, Chaofan Ding, Chuannan Luo, Qin Wei
18-facet polyhedron Cu7 S4 nanocrystal and CuS sphere were prepared from Cu2 O precursor, and CuS flower was synthesized through a simple solvothermal approach. Their electrochemical performances were investigated towards H2 O2 and it was interesting to discover that Cu7 S4 nanocrystal had the best electrochemical catalysis compared with CuS sphere and CuS flower. It can deduce that the special structure of Cu7 S4 nanocrystal endowed it more exposed active points, higher surface area and higher Cu/S ratio. Therefore, Cu7 S4 nanocrystal was firstly employed to prepare a nonenzymatic biosensor for H2 O2 ...
March 15, 2018: Biosensors & Bioelectronics
Yao Lu, Lihua Li, Zefeng Lin, Liping Wang, Lijun Lin, Mei Li, Yu Zhang, Qingshui Yin, Qi Li, Hong Xia
Rheumatoid arthritis (RA) is a worldwide inflammatory disease that seriously threatens human health and needs more effective treatment approaches. Near infrared (NIR) light can efficiently penetrate inflamed joints affected by RA, so phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), may provide new opportunities. In this work, the unique Cu7.2 S4 nanoparticles (NPs) are prepared for RA treatment enlightened by the fact that copper (Cu)-based nanomaterials can simultaneously serve as PTT agents and photosensitizers (for PDT)...
April 26, 2018: Advanced Healthcare Materials
Jing Zhou, Chunling Fu, Shengming Ma
γ-(E)-Vinylic and γ-alkylic γ-butyrolactones are two different types of lactones existing extensively in animals and plants and many of them show interesting biological activities. Nature makes alkylic γ-butyrolactones by many different enzymatic lactonization processes. Scientists have been mimicking the natural strategy by developing new catalysts. However, direct and efficient access to γ-(E)-vinylic γ-butyrolactones is still extremely limited. Here, we wish to present our modular allene approach, which provides an efficient asymmetric approach to (E)-vinylic γ-butyrolactones from allenoic acids by identifying a new gold complex as the catalyst...
April 25, 2018: Nature Communications
Shang Gao, O Zaharko, V Tsurkan, L Prodan, E Riordan, J Lago, B Fåk, A R Wildes, M M Koza, C Ritter, P Fouquet, L Keller, E Canévet, M Medarde, J Blomgren, C Johansson, S R Giblin, S Vrtnik, J Luzar, A Loidl, Ch Rüegg, T Fennell
Excitations in a spin ice behave as magnetic monopoles, and their population and mobility control the dynamics of a spin ice at low temperature. CdEr_{2}Se_{4} is reported to have the Pauling entropy characteristic of a spin ice, but its dynamics are three orders of magnitude faster than the canonical spin ice Dy_{2}Ti_{2}O_{7}. In this Letter we use diffuse neutron scattering to show that both CdEr_{2}Se_{4} and CdEr_{2}S_{4} support a dipolar spin ice state-the host phase for a Coulomb gas of emergent magnetic monopoles...
March 30, 2018: Physical Review Letters
Yang Chi, Liang-Zhen Rong, Nian-Tzu Suen, Huai-Guo Xue, Sheng-Ping Guo
Reported are the synthesis and structural characterization of a new series of ternary rare-earth mix-chalcogenides RE4 S4 Te3 (RE = Gd, Ho, Er, Tm) that have been obtained from high-temperature solid state reactions. These compounds crystallize in Ho4 S4 Te2.68 structure types with monoclinic C2/ m and/or orthorhombic Immm space groups. The space group variation within this series is due to the position disorder along the Te plane (Te to TeA and TeB). The structural relationship and change between these two space groups are analyzed...
April 25, 2018: Inorganic Chemistry
Masato Hioki, Takuya Shimada, Tian Yuan, Takeo Nakanishi, Hidehiro Tajima, Maiko Yamazaki, Rina Yokono, Makiko Takabayashi, Kazuki Sawamoto, Gaku Akashita, Ken-Ichi Miyamoto, Tetsuo Ohta, Ikumi Tamai, Tsutomu Shimada, Yoshimichi Sai
Hepatic arterial infusion (HAI) chemotherapy is expected to be a more effective and safer method to treat the hepatic metastasis of pancreatic cancer than intravenous (i.v.) administration because of higher tumor exposure and lower systemic exposure. To clarify the uptake mechanism of nucleoside anticancer drugs, including gemcitabine (GEM), in pancreatic cancer, we investigated the uptakes of radiolabeled uridine (a general substrate of nucleoside transporters) and GEM in pancreatic cancer cell lines MIA-PaCa2 and As-PC1...
April 22, 2018: Biopharmaceutics & Drug Disposition
Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly
The in vitro antidiabetic and antihyperlipidemic activities of an alcoholic extract of Trigonella stellata were evaluated in terms of the activation of PPARα and PPARγ in human hepatoma (HepG2) cells. The extract was investigated phytochemically, aiming at the isolation of the most active compounds to be used as a platform for drug discovery. Three new isoflavans, (3 S,4 R)-4,2',4'-trihydroxy)-7-methoxyisoflavan (1), (3 R,4 S)-4,2',4'-trihydroxy-7-methoxy-4'- O-β-d-glucopyranosylisoflavan (2), and (2 S,3 R,4 R)-4,2',4'-trihydroxy-2,7-dimethoxyisoflavan (3), were isolated and characterized along with the five known compounds p-hydroxybenzoic acid (4), 7,4'-dihydroxyflavone (5), dihydromelilotoside (6), quercetin-3,7- O-α-l-dirhamnoside (7), and soyasaponin I (8)...
April 20, 2018: Journal of Natural Products
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"