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https://www.readbyqxmd.com/read/29326970/revisiting-sweat-chloride-test-results-based-on-recent-guidelines-for-diagnosis-of-cystic-fibrosis
#1
Jayson V Pagaduan, Mahesheema Ali, Michael Dowlin, Liye Suo, Tabitha Ward, Fadel Ruiz, Sridevi Devaraj
Objectives: Recent sweat chloride guidelines published by the Cystic Fibrosis Foundation changed the intermediate sweat chloride concentration range from 40-59 mmol/L to 30-59 mmol/L for age > 6 months. We wanted to know how this new guideline would impact detection of cystic fibrosis among patients who previously had sweat tests done at Texas Children's Hospital. Methods: We revisited sweat chloride test results (n = 3012) in the last 5 years at Texas Children's Hospital based on the new guidelines on diagnosis of cystic fibrosis from the Cystic Fibrosis Foundation...
March 2018: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/29325334/-analysis-on-the-novel-compound-heterozygous-mutation-f%C3%A2-%C2%AA-of-a-patient-with-hereditary-factor-%C3%A2-%C2%AA-deficiency
#2
K Xu, K Y Shu, F F Li, T Chen, J Liu, S S Jin, J J Guo, Z H Zhang, M H Jiang
Objective: To investigate the clinical phenotype and genotype characteristics of a Chinese hereditary factor Ⅺ deficiency pedigree. Methods: The activated partial thromboplastin time (APTT), prothrombin time (PT), FⅪ activity (FⅪ: C) were measured by clotting method using automatic coagulation analyzer. The FⅪ antigen (FⅪ: Ag) was assayed by enzyme-linked immunosorbent assay (ELISA). Fifteen exons of F11 from the proband and his pedigree members were amplified by polymerase chain reaction (PCR), then sequenced...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29318895/acute-effect-of-coffee-on-aortic-stiffness-and-wave-reflections-in-healthy-individuals-differential-effect-according-to-habitual-consumption
#3
Nikolaos Ioakeimidis, Vaios Tzifos, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Christos Georgakopoulos, Dimitrios Tousoulis
The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: (a) coffee espresso, (b) decaffeinated coffee espresso, (c) caffeine alone and (d) placebo (hot water). The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0...
January 10, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29315577/bidirectional-variation-in-glutamate-efflux-in-the-medial-prefrontal-cortex-induced-by-selective-positive-and-negative-allosteric-mglur5-modulators
#4
Sarah N Isherwood, Trevor W Robbins, Jeffrey W Dalley, Anton Pekcec
Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive dysfunction and impaired inhibitory control in such neuropsychiatric disorders as schizophrenia, attention deficit hyperactivity disorder and drug addiction. Although NMDA receptors functionally interact with metabotropic glutamate receptor 5 (mGluR5), the consequence of this interaction for glutamate release in the prefrontal cortex (PFC) is unknown. We therefore investigated the effects of positive and negative allosteric mGluR5 modulation on changes in extracellular glutamate efflux in the medial PFC (mPFC) induced by systemic administration of the non-competitive NMDA receptor antagonist dizocilpine (or MK801) in rats...
January 6, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29277384/effectiveness-of-visual-warnings-on-young-drivers-hazard-anticipation-and-hazard-mitigation-abilities
#5
Foroogh Hajiseyedjavadi, Tingru Zhang, Ravi Agrawal, Michael Knodler, Donald Fisher, Siby Samuel
Previous studies have demonstrated that young drivers fail both to scan for and mitigate latent hazards mostly due to their cluelessness. This study aims to investigate whether these skills could be improved by providing young drivers with alerts in advance of the upcoming threat using a driving simulator experiment. In particular, the warning was presented on the head-up displays (HUD) either 2 s, 3 s or 4 s in advance of a latent threat. The hazard anticipation, hazard mitigation and attention maintenance performance of forty-eight young drivers aged 18-25 was evaluated across eight unique scenarios either in the presence or in the absence of latent threat alerts displayed on a HUD...
December 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29251548/rural-aging-in-america-proceedings-of-the-2017-connectivity-summit
#6
Alexis Skoufalos, Janice L Clarke, Dana Rose Ellis, Vicki L Shepard, Elizabeth Y Rula
Rural Aging in America: Proceedings of the 2017 Connectivity Summit Alexis Skoufalos, EdD, Janice L. Clarke, RN, BBA, Dana Rose Ellis, BA, Vicki L. Shepard, MSW, MPA, and Elizabeth Y. Rula, PhD Editorial: Creating a Movement to Transform Rural Aging David B. Nash, MD, MBA, with Donato J. Tramuto, and Joseph F. Coughlin, PhD   S-3 Introduction   S-4 Summit Proceedings   S-5 Roundtable 1: The Power of Community - Enabling Social Connections and Access to Health Resources Through Community-Based Programs   S-5 Roundtable 2: Technology and Rural Health: Innovative Solutions to Bridge the Distance, Improve Care, and Deliver Programs   S-7 Roundtable 3: An Integrated Experience: The Exponential Potential of a Collaborative Approach to Rural Aging   S-8 General Discussion and Recommendations   S-8 Post-Summit Debriefing   S-9 Strategy and objectives   S-9 6-12 month action plan   S-9 Conclusion   S-9...
December 2017: Population Health Management
https://www.readbyqxmd.com/read/29223189/the-evaluation-of-arterial-stiffness-of-essential-hypertension-and-white-coat-hypertension-in-children-a-case-control-study
#7
Semiha Terlemez Tokgöz, Dilek Yılmaz, Yavuz Tokgöz, Bülent Çelik, Yasin Bulut
BACKGROUND: The aim of this study was to determine and compare cardiovascular risks by assessing arterial stiffness in children with essential hypertension and white coat hypertension. METHODS: Paediatric patients followed up with essential hypertension and white coat hypertension diagnoses and with no established end organ damage were involved in the study. Arterial stiffness in children included in the study was evaluated and compared by using the oscillometric device (Mobil-O-Graph) method...
December 10, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29221672/cost-and-use-of-pasteurized-donor-human-milk-at-a-children-s-hospital
#8
Diane L Spatz, Abbey C Robinson, Elizabeth B Froh
OBJECTIVE: To determine the cost and use of pasteurized donor human milk (PDHM) at a children's hospital with a strong human milk culture. DESIGN: A retrospective descriptive cohort study. SETTING: A children's hospital in the northeastern region of the United States. PARTICIPANTS: Infants (N = 281) younger than 1 year of age at the time of hospitalization who received PDHM between January 2011 and November 2014. Infants older than 1 year of age at the time of hospitalization were excluded from the study sample...
December 5, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29200286/ligand-effect-on-the-single-molecule-magnetism-of-tetranuclear-co-ii-cubane
#9
Xiong-Feng Ma, Zhenxing Wang, Xue-Li Chen, Mohamedally Kurmoo, Ming-Hua Zeng
A clear dependence on the ligand has been observed for the magnetic properties of a closely related series of Co(II) cubane structures, viz. [Co4(mbm or bm)4(ROH)4Br4] (1-MeOH, 1-EtOH, 2-MeOH, and 2-EtOH, where 1 = [Co4(mbm)4Br4], 2 = [Co4(bm)4Br4], bm = (1H-benzo[d]imidazol-2-yl)methanolate. and mbm = 1-Me-bm.) The [Co4(OR)4] cubane core consists of an octahedral CoII center chelated by the alkoxide oxygen and imidazole nitrogen atoms from monoanionic bm or mbm and coordinated by methanol/alcohol and bromine...
December 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29180359/tegoprazan-a-novel-potassium-competitive-acid-blocker-to-control-gastric-acid-secretion-and-motility
#10
Nobuyuki Takahashi, Yukinori Take
Tegoprazan, (S)-4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide, a potassium-competitive acid blocker (P-CAB), is a novel potent and highly selective inhibitor of gastric H+/K+-ATPase. Tegoprazan inhibited porcine, canine, and human H+/K+-ATPases in vitro with IC50 values ranging 0.29 ~ 0.52 μM while that for canine kidney Na+/K+-ATPase was more than 100 μM. A kinetic analysis revealed that tegoprazan inhibited H+/K+-ATPase with potassium-competitive manner and the binding was reversible...
November 27, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29153256/intraoperative-force-and-electrocochleography-measurements-in-an-animal-model-of-cochlear-implantation
#11
J Lo, C Bester, A Collins, C Newbold, A Hampson, S Chambers, H Eastwood, S O'Leary
To preserve residual hearing, techniques for monitoring and reducing the effects of trauma during cochlear implant surgery are being developed. This study examines the relationships between intraoperative recordings (electrode insertion force and electrocochleography), trauma, and hearing loss after cochlear implantation. The study also evaluated the efficacy of intravenous steroids for reducing hearing loss after implantation. Thirty-two normal-hearing guinea pigs were randomly implanted with electrode arrays of differing stiffness ('hard' or 'soft')...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29128943/effects-of-biochar-on-phytotoxicity-and-translocation-of-polybrominated-diphenyl-ethers-in-ni-fe-bimetallic-nanoparticle-treated-soil
#12
Juan Wu, Yunqiang Yi, Zhanqiang Fang, Eric Pokeung Tsang
In this study, soil culture experiments were conducted to explore the effects of biochar-supported Ni/Fe nanoparticles on the accumulation and translocation of polybrominated diphenyl ethers (PBDEs) in soil-plant system and its phytotoxicity to Brassica chinensis. Compared with those in BDE209 contaminated soils (S 1) and Ni/Fe nanoparticle-treated soil (S 3), the plant biomass, root, and shoot lengths in biochar-supported Ni/Fe nanoparticle-treated soil (S 4) were increased by 23 mg, 1.35 cm, and 2.08 cm and 27...
November 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29126977/enhancement-of-inosine-mediated-a2ar-signaling-through-positive-allosteric-modulation
#13
Ajith A Welihinda, Manmeet Kaur, Kaviya S Raveendran, Edward P Amento
Inosine is an endogenous nucleoside that is produced by metabolic deamination of adenosine. Inosine is metabolically more stable (half-life 15h) than adenosine (half-life <10s). Inosine exerts anti-inflammatory and immunomodulatory effects similar to those observed with adenosine. These effects are mediated in part through the adenosine A2A receptor (A2AR). Relative to adenosine inosine exhibits a lower affinity towards the A2AR. Therefore, it is generally believed that inosine is incapable of activating the A2AR through direct engagement, but indirectly activates the A2AR upon metabolic conversion to higher affinity adenosine...
November 8, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29089942/the-possible-influence-of-non-synonymous-point-mutations-within-the-fima-adhesin-of-non-typhoidal-salmonella-nts-isolates-in-the-process-of-host-adaptation
#14
Sahar Alshalchi, Shivdeep S Hayer, Ran An, Jeannette Munoz-Aguayo, Christian Flores-Figueroa, Ryan Nguyen, Dale Lauer, Karen Olsen, Julio Alvarez, David Boxrud, Carol Cardona, Sinisa Vidovic
Non-typhoidal Salmonella (NTS) remains a global pathogen that affects a wide range of animal species. We analyzed a large number of NTS isolates of different host origins, including Salmonella Heidelberg (n = 80, avian), S. Dublin (50, bovine), S. Typhimurium var 5- (n = 40, porcine), S. 4,5,12,:i:- (n = 40, porcine), S. Cerro (n = 16, bovine), and S. Montevideo (n = 14, bovine), using virulence profiling of the bcfC, mgtC, ssaC, invE, pefA, stn, sopB, and siiE virulence-associated genes, a biofilm production assay, pulsed field gel electrophoresis, and the full-length sequencing of the fimA (adhesin) and iroN (receptor) genes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29083904/insights-on-the-realgar-crystal-under-pressure-from-xp-pcm-and-periodic-model-calculations
#15
Chiara Caratelli, Roberto Cammi, Riccardo Chelli, Marco Pagliai, Gianni Cardini, Vincenzo Schettino
The spectroscopic properties of As4S4 with pressure have been computed by the quantum mechanical XP-PCM method and by density functional theory periodic calculations. The comparison has allowed the interpretation of the available experimental data. By comparison of the two methods and with experiments, we show that the XP-PCM method is able to reproduce the same behavior of the periodic calculations with much lower computational cost allowing to be adopted as a first choice computational tool for a qualitative interpretation of molecular crystals properties under pressure...
November 10, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29072464/enantioselective-iridium-catalyzed-hydrogenation-of-%C3%AE-keto-amides-to-%C3%AE-hydroxy-amides
#16
Guoxian Gu, Tilong Yang, Ouran Yu, Hua Qian, Jiang Wang, Jialin Wen, Li Dang, Xumu Zhang
A highly enantioselective iridium-catalyzed hydrogenation of α-keto amides to form α-hydroxy amides has been achieved with excellent results (up to >99% conversion and up to >99% ee, TON up to 100 000). As an example, this protocol was applied to the synthesis of (S)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol, the enantiomer of norepinephrine, which is widely used as an injectable drug for the treatment of critically low blood pressure. Density functional theory (DFT) calculations were also carried out to reveal the reaction mechanism...
October 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/29069323/salmonella-enterica-serotype-4-5-12-i-in-swine-in-the-united-states-midwest-an-emerging-multidrug-resistant-clone
#17
Ehud Elnekave, Samuel Hong, Alison E Mather, Dave Boxrud, Angela J Taylor, Victoria Lappi, Timothy J Johnson, Fabio Vannucci, Peter Davies, Craig Hedberg, Andres Perez, Julio Alvarez
Background: Salmonella 4,[5],12:i:-, a worldwide emerging pathogen that causes many foodborne outbreaks mostly attributed to pig and pig products, is expanding in the U.S. Methods: Whole genome sequencing was applied to conduct multiple comparisons of 659 S. 4,[5],12:i:- and 325 S. Typhimurium from different sources and locations (i.e. U.S. and Europe) to assess their genetic heterogeneity, with a focus on strains recovered from swine in the U.S. Midwest. In addition, presence of resistance genes and other virulence factors was detected and the antimicrobial resistance phenotype of 50 and 22 isolates of livestock and human origin, respectively, was determined...
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29055025/contribution-of-equilibrative-nucleoside-transporter-s-to-intestinal-basolateral-and-apical-transports-of-anticancer-trifluridine
#18
Koichi Takahashi, Kunihiro Yoshisue, Masato Chiba, Takeo Nakanishi, Ikumi Tamai
Trifluridine (FTD) exhibits anticancer activities after its oral administration despite its hydrophilic nature. We previously reported that concentrative nucleoside transporter (CNT) 1 mediates the apical uptake of FTD in human small intestinal epithelial cells (HIECs). In the present study, FTD was also identified as a substrate for equilibrative nucleoside transporter (ENT) 1 and ENT2 in transporter gene-transfected cells. An immunocytochemical analysis revealed that ENT1 was expressed at the basolateral and apical membranes of HIECs...
October 20, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29041760/10-m-9-51-gb-s-rgb-laser-diodes-based-wdm-underwater-wireless-optical-communication
#19
Meiwei Kong, Weichao Lv, Tariq Ali, Rohail Sarwar, Chuying Yu, Yang Qiu, Fengzhong Qu, Zhiwei Xu, Jun Han, Jing Xu
The availability of the underwater wireless optical communication (UWOC) based on red (R), green (G) and blue (B) lights makes the realization of the RGB wavelength division multiplexing (WDM) UWOC system possible. By properly mixing RGB lights to form white light, the WDM UWOC system has prominent potentiality for simultaneous underwater illumination and high-speed communication. In this work, for the first time, we experimentally demonstrate a 9.51-Gb/s WDM UWOC system using a red-emitting laser diode (LD), a single-mode pigtailed green-emitting LD and a multi-mode pigtailed blue-emitting LD...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29038973/production-of-ethylene-glycol-or-glycolic-acid-from-d-xylose-in-saccharomyces-cerevisiae
#20
Laura Salusjärvi, Mervi Toivari, Maija-Leena Vehkomäki, Outi Koivistoinen, Dominik Mojzita, Klaus Niemelä, Merja Penttilä, Laura Ruohonen
The important platform chemicals ethylene glycol and glycolic acid were produced via the oxidative D-xylose pathway in the yeast Saccharomyces cerevisiae. The expression of genes encoding D-xylose dehydrogenase (XylB) and D-xylonate dehydratase (XylD) from Caulobacter crescentus and YagE or YjhH aldolase and aldehyde dehydrogenase AldA from Escherichia coli enabled glycolic acid production from D-xylose up to 150 mg/L. In strains expressing only xylB and xylD, 29 mg/L 2-keto-3-deoxyxylonic acid [(S)-4,5-dihydroxy-2-oxopentanoic acid] (2K3DXA) was produced and D-xylonic acid accumulated to ca...
October 16, 2017: Applied Microbiology and Biotechnology
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