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https://www.readbyqxmd.com/read/28427921/enhancement-of-ethyl-s-4-chloro-3-hydroxybutanoate-production-at-high-substrate-concentration-by-in-situ-resin-adsorption
#1
Li-Feng Chen, Hai-Yang Fan, Yi-Ping Zhang, Wei Wei, Jin-Ping Lin, Dong-Zhi Wei, Hua-Lei Wang
Asymmetric reduction of ethyl 4-chloro-3-oxobutyrate (COBE) by carbonyl reductases presents an efficient way to produce Ethyl (S)-4-chloro-3-hydroxybutanoate ((S)-CHBE), an important chiral intermediate for the synthesis of hydroxymethylglutaryl-CoA reductase inhibitors such as Lipitor(®). In this study, an NADPH-dependent carbonyl reductase (SrCR) from Synechocystis sp. was characterized to demonstrate a broad substrate spectrum, and the highest activity (53.1U/mg protein) with COBE. To regenerate the cofactor NADPH, Bacillus subtilis glucose dehydrogenase was successfully coexpressed with SrCR...
April 17, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28419755/a-diagnostic-algorithm-for-assessment-of-liver-fibrosis-by-liver-stiffness-measurement-in-patients-with-chronic-hepatitis-b
#2
Yi-Jing Cai, Jia-Jia Dong, Xiao-Dong Wang, Si-Si Huang, Rui-Cong Chen, Yi Chen, Yu-Qun Wang, Mei Song, Yong-Ping Chen, Zhuo Li, Meng-Tao Zhou, Ke-Qing Shi
Steatosis could affect liver stiffness measurement in patients with nonalcoholic fatty liver disease and chronic hepatitis C. In the current study, we aimed to investigate the impact of steatosis on liver stiffness in chronic hepatitis B virus infected patients and develop a diagnostic algorithm for prediction of liver fibrosis by liver stiffness based on the controlled attenuation parameter. A total of 488 HBV infected patients who underwent clinical examination, FibroScan and liver biopsy were prospectively enrolled...
April 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28412676/investigation-of-sub-health-status-of-neonates-in-heping-street-region-beijing-and-analysis-on-related-risk-factors
#3
Chen Jie, Shi Mai, Li Qiuju, Ye Fang, Liu Fang, Fan Qinying, Zhang Yong, Wang Lin
To investigate sub-health status of neonates in Heping Street Region and related risk factors. Then, 7436 maternal women admitted to hospital in Heping Street Region, Beijing were enrolled from October 2013 to September 2015, including 293 women, who gave birth to sub-health neonates. Questionnaire survey was conducted to collect maternal age, education degree, experiences and income, occupation, life habit, condition in pregnancy, condition in perinatal period, adverse reaction in pregnancy, etc. Finally, 281 effective questionnaires were regained with effective regain rate of 95...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28407352/copper-catalyzed-aminothiolation-of-1-3-dienes-via-a-dihydrothiazine-intermediate
#4
Christopher E Sleet, Uttam K Tambar
Heteroatom-containing organic molecules are of particular interest to medicinal chemists and materials scientists. A strategy to reach these architectures via direct difunctionalization of abundant 1,3-dienes is especially attractive. Herein, we describe the development of a regio- and diastereoselective 1,4-aminothiolation of 1,3-dienes with a sulfur diimide reagent, a copper catalyst, and alkyl Grignard reagents. This unique protocol provides remote nitrogen and sulfur functionalities with high levels of stereocontrol...
April 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28395308/evaluation-of-a-training-program-to-reduce-stressful-trunk-postures-in-the-nursing-professions-a-pilot-study
#5
Agnessa Kozak, Sonja Freitag, Albert Nienhaus
Objectives: The aim of this pilot study was to evaluate metrologically the effectiveness of a training program on the reduction of stressful trunk postures in geriatric nursing professions. Methods: A training program, consisting of instruction on body postures in nursing, practical ergonomic work methods at the bedside or in the bathroom, reorganization of work equipment, and physical exercises, was conducted in 12 wards of 6 nursing homes in Germany. The Computer-Assisted Recording and Long-Term Analysis of Musculoskeletal Loads (CUELA) measurement system was used to evaluate all movements and trunk postures adopted during work before and 6 months after the training program...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28392421/phenylalanine-ammonia-lyase-from-arabidopsis-thaliana-atpal2-a-potent-enzyme-for-the-synthesis-of-non-canonical-aromatic-alpha-amino-acids-part-i-comparative-characterization-to-the-enzymes-from-petroselinum-crispum-pcpal1-and-rhodosporidium-toruloides-rtpal
#6
Alana Dreßen, Thomas Hilberath, Ursula Mackfeld, Arne Billmeier, Jens Rudat, Martina Pohl
Phenylalanine ammonia lyase (PAL) from Arabidopsis thaliana (AtPAL2) was comparatively characterized to the well-studied enzyme from parsley (PcPAL1) and Rhodosporidium toruloides (RtPAL) with respect to kinetic parameters for the deamination and the amination reaction, pH- and temperature optima and the substrate range of the amination reaction. Whereas both plant enzymes are specific for phenylalanine, the bifunctional enzyme from Rhodosporidium toruloides shows KM-values for L-Phe and L-Tyr in the same order of magnitude and, compared to both plant enzymes, a 10-15-fold higher activity...
April 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28389544/engineering-streptomyces-coelicolor-carbonyl-reductase-for-efficient-synthesis-of-atorvastatin-precursor
#7
Min Li, Zhi-Jun Zhang, Xu-Dong Kong, Hui-Lei Yu, Jiahai Zhou, Jian-He Xu
ScCR1 has been shown to be a promising biocatalyst for the synthesis of an atorvastatin precursor, ethyl (S)-4-chloro-3-hydroxybutyrate. However, limitations of ScCR1 observed for practical application include the low activity and poor stability. In this work, protein engineering was employed to improve the catalytic efficiency and stability of ScCR1. At first, the crystal structure of ScCR1 complexed with NADH and co-substrate 2-propanol was solved, and the specific activity of ScCR1 was increased from 38...
April 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28387663/quantitative-parameters-of-contrast-enhanced-ultrasound-in-breast-invasive-ductal-carcinoma-the-correlation-with-pathological-prognostic-factors
#8
Chen-Li Ji, Xiao-Long Li, Ya-Ping He, Dan-Dan Li, Xin-Gang Gu, Hui-Xiong Xu
PURPOSE: To investigate the correlation between quantitative parameters on contrast-enhanced ultrasound (CEUS) and pathological prognostic factors in patients with breast invasive ductal carcinomas (IDCs). MATERIALS AND METHODS: 102 patients with pathologically proven IDCs were retrospectively enrolled and all were preoperatively evaluated by CEUS. Quantitative analysis was conducted using the SonoLiver® software. On the parametric imaging, the data of rise time (RT), time to peak (TTP), mean transit time (mTT) and maximum intensity (IMAX) were recorded...
April 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28375005/expanding-the-chemical-repertoire-of-the-endophyte-streptomyces-albospinus-rle7-reveals-amphotericin-b-as-an-inducer-of-a-fungal-phenotype
#9
Fernanda Oliveira Chagas, Andrés Mauricio Caraballo-Rodríguez, Pieter C Dorrestein, Mônica Tallarico Pupo
During an investigation of the chemistry of the endophytic actinobacterium Streptomyces albospinus RLe7, which was isolated from the roots of the Brazilian medicinal plant Lychnophora ericoides, three new natural products, (2R*,4S*)-2-((1'S*)-hydroxy-4'-methylpentyl)-4-(hydroxymethyl)butanolide (1), (3R*,4S*,5R*,6S*)-tetrahydro-4-hydroxy-3,5,6-trimethyl-2-pyranone (2), and 1-O-(phenylacetyl)glycerol (3), together with known secondary metabolites (S)-4-benzyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (4), (S)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (5), and the diketopiperazines cyclo(l-Tyr-l-Pro) (6) and cyclo(l-Val-l-Pro) (7), were isolated...
April 4, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28374860/640-gbit-s-fast-physical-random-number-generation-using-a-broadband-chaotic-semiconductor-laser
#10
Limeng Zhang, Biwei Pan, Guangcan Chen, Lu Guo, Dan Lu, Lingjuan Zhao, Wei Wang
An ultra-fast physical random number generator is demonstrated utilizing a photonic integrated device based broadband chaotic source with a simple post data processing method. The compact chaotic source is implemented by using a monolithic integrated dual-mode amplified feedback laser (AFL) with self-injection, where a robust chaotic signal with RF frequency coverage of above 50 GHz and flatness of ±3.6 dB is generated. By using 4-least significant bits (LSBs) retaining from the 8-bit digitization of the chaotic waveform, random sequences with a bit-rate up to 640 Gbit/s (160 GS/s × 4 bits) are realized...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28368651/observation-of-%C3%AE-_-c-%C3%A2-nk_-s-0-%C3%AF
#11
M Ablikim, M N Achasov, S Ahmed, X C Ai, O Albayrak, M Albrecht, D J Ambrose, A Amoroso, F F An, Q An, J Z Bai, O Bakina, R Baldini Ferroli, Y Ban, D W Bennett, J V Bennett, N Berger, M Bertani, D Bettoni, J M Bian, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J F Chang, G Chelkov, G Chen, H S Chen, J C Chen, M L Chen, S Chen, S J Chen, X Chen, X R Chen, Y B Chen, X K Chu, G Cibinetto, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Z Fan, J Fang, S S Fang, X Fang, Y Fang, R Farinelli, L Fava, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, Y Gao, Z Gao, I Garzia, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, Y H Guan, A Q Guo, L B Guo, R P Guo, Y Guo, Y P Guo, Z Haddadi, A Hafner, S Han, X Q Hao, F A Harris, K L He, F H Heinsius, T Held, Y K Heng, T Holtmann, Z L Hou, C Hu, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Z L Huang, T Hussain, W Ikegami Andersson, Q Ji, Q P Ji, X B Ji, X L Ji, L W Jiang, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X L Kang, X S Kang, M Kavatsyuk, B C Ke, P Kiese, R Kliemt, B Kloss, O B Kolcu, B Kopf, M Kornicer, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, L Lavezzi, H Leithoff, C Leng, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, Jin Li, K Li, K Li, Lei Li, P R Li, Q Y Li, T Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Y B Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H H Liu, H H Liu, H M Liu, J Liu, J B Liu, J P Liu, J Y Liu, K Liu, K Y Liu, L D Liu, P L Liu, Q Liu, Q J Liu, S B Liu, X Liu, Y B Liu, Y Y Liu, Z A Liu, Z Q Liu, H Loehner, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Q A Malik, Y J Mao, Z P Mao, S Marcello, J G Messchendorp, G Mezzadri, J Min, T J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, P Musiol, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, P Patteri, M Pelizaeus, H P Peng, K Peters, J Pettersson, J L Ping, R G Ping, R Poling, V Prasad, H R Qi, M Qi, S Qian, C F Qiao, L Q Qin, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Ripka, G Rong, Ch Rosner, X D Ruan, A Sarantsev, M Savrié, C Schnier, K Schoenning, W Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, W M Song, X Y Song, S Sosio, S Spataro, G X Sun, J F Sun, S S Sun, X H Sun, Y J Sun, Y Z Sun, Z J Sun, Z T Sun, C J Tang, X Tang, I Tapan, E H Thorndike, M Tiemens, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, K Wang, L L Wang, L S Wang, M Wang, P Wang, P L Wang, W Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z H Wang, Z Y Wang, T Weber, D H Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, L G Xia, Y Xia, D Xiao, H Xiao, Z J Xiao, Y G Xie, Yuehong Xie, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y X Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, J S Yu, C Z Yuan, Y Yuan, A Yuncu, A A Zafar, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y Zhang, Y H Zhang, Y N Zhang, Y T Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, Q W Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, L Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, L Zotti, B S Zou, J H Zou
We report the first direct measurement of decays of the Λ_{c}^{+} baryon involving the neutron. The analysis is performed using 567  pb^{-1} of e^{+}e^{-} collision data collected at sqrt[s]=4.599  GeV with the BESIII detector at the BEPCII collider. We observe the decay Λ_{c}^{+}→nK_{S}^{0}π^{+} and measure the absolute branching fraction to be B(Λ_{c}^{+}→nK_{S}^{0}π^{+})=[1.82±0.23(stat)±0.11(syst)]%. A comparison to B[Λ_{c}^{+}→p(K[over ¯]π)^{0}] provides an important test of isospin symmetry and final state interactions...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28368105/triazolyl-imidazolyl-and-carboxylic-acid-moieties-in-the-design-of-molybdenum-trioxide-hybrids-photophysical-and-catalytic-behavior
#12
Andrey B Lysenko, Ganna A Senchyk, Konstantin V Domasevitch, Merten Kobalz, Harald Krautscheid, Jakub Cichos, Miroslaw Karbowiak, Patrícia Neves, Anabela A Valente, Isabel S Gonçalves
Three organic ligands bearing 1,2,4-triazolyl donor moieties, (S)-4-(1-phenylpropyl)-1,2,4-triazole (trethbz), 4-(1,2,4-triazol-4-yl)benzoic acid (trPhCO2H), and 3-(1H-imidazol-4-yl)-2-(1,2,4-triazol-4-yl)propionic acid (trhis), were prepared to evaluate their coordination behavior in the development of molybdenum(VI) oxide organic hybrids. Four compounds, [Mo2O6(trethbz)2]·H2O (1), [Mo4O12(trPhCO2H)2]·0.5H2O (2a), [Mo4O12(trPhCO2H)2]·H2O (2b), and [Mo8O25(trhis)2(trhisH)2]·2H2O (3), were synthesized and characterized...
April 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28358882/proteomic-analysis-of-organic-sulfur-compound-utilisation-in-advenella-mimigardefordensis-strain-dpn7t
#13
Christina Meinert, Ulrike Brandt, Viktoria Heine, Jessica Beyert, Sina Schmidl, Jan Hendrik Wübbeler, Birgit Voigt, Katharina Riedel, Alexander Steinbüchel
2-Mercaptosuccinate (MS) and 3,3´-ditiodipropionate (DTDP) were discussed as precursor substance for production of polythioesters (PTE). Therefore, degradation of MS and DTDP was investigated in Advenella mimigardefordensis strain DPN7T, applying differential proteomic analysis, gene deletion and enzyme assays. Protein extracts of cells cultivated with MS, DTDP or 3-sulfinopropionic acid (SP) were compared with those cultivated with propionate (P) and/or succinate (S). The chaperone DnaK (ratio DTDP/P 9.2, 3SP/P 4...
2017: PloS One
https://www.readbyqxmd.com/read/28348215/plp-and-gaba-trigger-gabr-mediated-transcription-regulation-in-bacillus-subtilis-via-external-aldimine-formation
#14
Rui Wu, Ruslan Sanishvili, Boris R Belitsky, Jose I Juncosa, Hoang V Le, Helaina J S Lehrer, Michael Farley, Richard B Silverman, Gregory A Petsko, Dagmar Ringe, Dali Liu
The Bacillus subtilis protein regulator of the gabTD operon and its own gene (GabR) is a transcriptional activator that regulates transcription of γ-aminobutyric acid aminotransferase (GABA-AT; GabT) upon interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promotes the biosynthesis of glutamate from GABA. We show here that the external aldimine formed between PLP and GABA is apparently responsible for triggering the GabR-mediated transcription activation. Details of the "active site" in the structure of the GabR effector-binding/oligomerization (Eb/O) domain suggest that binding a monocarboxylic γ-amino acid such as GABA should be preferred over dicarboxylic acid ligands...
March 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28321483/distribution-of-kawasaki-disease-coronary-artery-aneurysms-and-the-relationship-to-coronary-artery-diameter
#15
Etsuko Tsuda, Nobuyuki Tsujii, Kohji Kimura, Atsuko Suzuki
We investigated how the diameter of coronary artery aneurysm (CAA) relates to the distribution immediately after Kawasaki disease (KD). Two hundred and four pts (155 males and 49 females) who had undergone selective coronary angiography (CAGs) less than 100 days after the onset of KD were studied. We measured the maximum diameter of each artery segment in the initial CAGs. We analyzed the relationship between the maximum diameters and the distribution of CAA. We divided the patients into four groups based on the maximum CAA diameter in each patient (large(L) ≥8 mm, medium(M) ≥6 and <8 mm, small(S) ≥4 and <6 mm, very small(VS) <4 mm) and counted the affected segments...
March 20, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28297842/numerical-evidence-of-hyperscaling-violation-in-wetting-transitions-of-the-random-bond-ising-model-in-d-2-dimensions
#16
Ezequiel V Albano, Luciana Luque, Marta L Trobo, Kurt Binder
We performed extensive simulations of the random-bond Ising model confined between walls where competitive surface fields act. By properly taking the thermodynamic limit we unambiguously determined wetting transition points of the system, as extrapolation of localization-delocalization transitions of the interface between domains of different orientation driven by the respective fields. The finite-size scaling theory for wetting with short-range fields [E. V. Albano and K. Binder, Phys. Rev. Lett. 109, 036101 (2012)PRLTAO0031-900710...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28294584/ige-igg1-and-igg4-response-to-specific-allergens-in-sensitized-subjects-showing-different-clinical-reactivity-to-anisakis-simplex
#17
M T Ventura, R Rodriguez-Perez, M L Caballero, M Garcia-Alonso, L Antonicelli, R Asero
Background. Anisakis simplex hypersensitive subjects may be sensitized without clinical allergy, or experience acute symptoms or chronic urticaria induced by raw fish. We studied whether the 3 subgroups differ in IgE, IgG1 or IgG4 reactivity to specific Anisakis simplex allergens. Methods. 28 Anisakis simplex-hypersensitive adults, 11 with acute symptoms, 9 with chronic urticaria, and 8 sensitized were studied. IgE, IgG1 and IgG4 to rAni s 1, 5, 9 and 10 were sought by ELISA. IgE and IgG4 to nAni s 4 were determined by WB...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28292464/intracellular-acidification-increases-adenosine-transport-in-human-umbilical-vein-endothelial-cells
#18
Natalia Celis, Joaquín Araos, Carlos Sanhueza, Fernando Toledo, Ana R Beltrán, Fabián Pardo, Andrea Leiva, Marco A Ramírez, Luis Sobrevia
INTRODUCTION: Adenosine is taken up via human equilibrative nucleoside transporters 1 (hENT1) and 2 (hENT2) at a physiological extracellular pH (pHo ∼7.4) in human umbilical vein endothelial cells (HUVECs). Acidic pHo increases the uptake of adenosine and 5-hydroxytryptamine (5HT) via hENT4 in this cell type. However, modulation of hENT1 and hENT2 transport activity by the pHi is unknown. We investigated whether hENT1 and hENT2-adenosine transport was regulated by acidic pHi. METHODS: HUVECs loaded with a pH sensitive probe were subjected to 0...
March 2017: Placenta
https://www.readbyqxmd.com/read/28270649/assessment-of-kidney-function-after-allograft-transplantation-by-texture-analysis
#19
Ali Abbasian Ardakani, Afshin Mohammadi, Bahareh Khalili Najafabad, Jamileh Abolghasemi
INTRODUCTION: Ultrasonography is the preferable imaging technique for monitoring and assessing complications in kidney allograft transplants. Computer-aided diagnostic system based on texture analysis in ultrasonographic imaging is recommended to identify changes in kidney function after allograft transplantation. MATERIALS AND METHODS: A total of 61 biopsy-proven kidney allograft recipients (11 rejected and 50 unrejected) were assessed by a computer-aided diagnostic system...
March 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28241896/salmonella-in-the-pork-production-chain-and-its-impact-on-human-health-in-the-european-union
#20
S Bonardi
Salmonella spp. comprise the second most common food-borne pathogens in the European Union (EU). The role of pigs as carriers of Salmonella has been intensively studied both on farm and at slaughter. Salmonella infection in pigs may cause fever, diarrhoea, prostration and mortality. However, most infected pigs remain healthy carriers, and those infected at the end of the fattening period could pose a threat to human health. Contamination of pig carcasses can occur on the slaughter line, and it is linked to cross-contamination from other carcasses and the presence of Salmonella in the environment...
February 28, 2017: Epidemiology and Infection
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