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Alexandra Zvereva, Nina Petoussi-Henss, Wei Bo Li, Helmut Schlattl, Uwe Oeh, Maria Zankl, Frank Philipp Graner, Christoph Hoeschen, Stephan G Nekolla, Katia Parodi, Markus Schwaiger
The objective of this work was to investigate the influence of the definition of blood as a distinct source on organ doses, associated with the administration of a novel radiopharmaceutical for positron emission tomography-computed tomography (PET/CT) imaging-(S)-4-(3-(18)F-fluoropropyl)-L-glutamic acid ((18)F-FSPG). Personalised pharmacokinetic models were constructed based on clinical PET/CT images from five healthy volunteers and blood samples from four of them. Following an identifiability analysis of the developed compartmental models, person-specific model parameters were estimated using the commercial program SAAM II...
October 14, 2016: Physics in Medicine and Biology
Yubao Lv, Linuo Zhou, Zihui Tang, Jingcheng Dong
BACKGROUND: This study assessed the extent to which diabetes mellitus (DM) and SCN10A (rs7375036) and their interaction impact on cardiovascular autonomic neuropathy (CAN) susceptibility in a Chinese Han sample. METHOD: We performed a study in a cross-sectional dataset that included 419 patients with DM and 1557 controls who were genotyped for the presence of the SCN10A rs7375036 polymorphisms. Genotyping was performed by iPLEX technology. The associations of rs7375036 and DM with CAN was assessed by using univariate and multivariate logistic regression controlling for confounders...
October 11, 2016: Postgraduate Medical Journal
S V Madhu, Abhishek Raj, Stuti Gupta, S Giri, Usha Rusia
BACKGROUND: We investigated the effect of iron deficiency anemia (IDA) on levels of glycated hemoglobin (HbA1c) and to compare its levels before and after iron supplementations. METHODS: Age and sex matched subjects were enrolled and clustered in 2 groups: IDA (n=62) and healthy controls (HC; n=60). HbA1c levels were estimated by HPLC. Hemogram were estimated by hematology analyser. Serum ferritin (ELISA) and other parameters of iron profile were measured by standard guidelines of ICSH...
October 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Zhuotao Tan, Hongmin Ma, Qing Li, Lingling Pu, Yang Cao, Xudong Qu, Chenjie Zhu, Hanjie Ying
The increasing demand for biocatalysts in synthesizing enantiomerically pure chiral alcohols results from the outstanding characteristics of enzymes in reaction, economic, ecological issues. Many carbonyl reductases for producing chiral alcohols have been reported but there is still a lack of good catalytic efficacies. Herein, five carbonyl reductases from different Streptomyces were discovered by the strategy of genome mining. These reductases were overexpressed, and we chose SgCR for further study as it owned better enzyme activity...
November 2016: Enzyme and Microbial Technology
K Udeni Alwis, T Liz Bailey, Dhrusti Patel, Liqun Wang, Benjamin C Blount
Isoprene, the 2-methyl analog of 1,3-butadiene, is identified as a possible human carcinogen by the International Agency for Research on Cancer (IARC). Isoprene is ubiquitous in the environment with numerous natural and anthropogenic sources. Tobacco smoke is the main exogenous source of isoprene exposure in indoor environments. Among smoke constituents, isoprene is thought to contribute significantly to cancer risk; however, no selective urinary biomarkers of isoprene exposure have been identified for humans...
October 19, 2016: Analytica Chimica Acta
Young Ri Kim, Ji Won Choi, Woo Seog Sim, Chul Joong Lee, Choohoon Chang
STUDY OBJECTIVE: Elderly patients with degenerative knee disease may have accompanying degenerative spine conditions. There are no studies on lumbar epidural catheter withdrawal forces in these patients. The aim of this study was to investigate withdrawal forces and possible associated risk factors in patients undergoing total knee arthroplasty (TKA). DESIGN: Prospective randomized trial. SETTING: Operating room and ward in a university hospital...
November 2016: Journal of Clinical Anesthesia
F Z Mokrane, R Colleter, S Duchesne, P Gerard, F Savall, E Crubezy, C Guilbeau-Frugier, R Moreno, A Sewonu, H Rousseau, N Telmon, F Dedouit
INTRODUCTION: Among 800 burials dated between the 15th and 18th centuries and found in the center of Rennes (Brittany, France), a collection of five heart-shaped lead urns was discovered. This material was studied using classical methods (external study, autopsy and histology), and also modern imaging like computed tomography (CT), magnetic resonance (MR) before and after coronary opacification. The aim of this manuscript is to describe different steps of ancient soft tissues study, especially using imaging techniques...
September 14, 2016: Forensic Science International
Jocelyn K Mara, Kevin G Thompson, Kate L Pumpa, Stuart Morgan
The aim of this study was to determine the high-speed running and sprinting profiles of elite female soccer players during competitive matches using a new Optical Player Tracking System. Eight stationary video cameras were positioned at vantage points surrounding the soccer field so that when each camera view was combined the entire field could be viewed simultaneously. Following each match, an optical player tracking system detected the coordinates (x,y) of each player for every video frame. Algorithms applied to the x and y coordinates were used to determine activity variables for twelve elite female players across seven competitive matches...
September 6, 2016: Journal of Strength and Conditioning Research
Pengyu Li, Jia Song, Xiaomin Ni, Qin Guo, Hui Wen, Qiuyun Zhou, Yuanna Shen, Yijun Huang, Pengxin Qiu, Suizhen Lin, Haiyan Hu
Hydroxypropyl-β-cyclodextrin (HP-β-CD) has been widely used as an effective solubilizing agent in pharmaceutical industry for many years. However, the effect of degree of substitution (D.S.) of HP-β-CD on solubilizing capacity and toxicity has not been concerned. In this study, solubilizing capacity of HP-β-CDs with three different D.S. (4.55, 6.16 and 7.76) for 16 drugs were measured and their toxicities were compared by a 7-day i.v. administration (q.d.) study in rats. Generally, HP-β-CD with high D...
September 11, 2016: International Journal of Pharmaceutics
Han Wang, Rui Yu, Ting Fang, Ting Yu, Xiangyang Chi, Xiaopeng Zhang, Shuling Liu, Ling Fu, Changming Yu, Wei Chen
Tetanus neurotoxin (TeNT) produced by Clostridium tetani is one of the most poisonous protein substances. Neutralizing antibodies against TeNT can effectively prevent and cure toxicosis. Using purified Hc fragments of TeNT (TeNT-Hc) as an antigen, three specific neutralizing antibody clones recognizing different epitopes were selected from a human immune scFv antibody phage display library. The three antibodies (2-7G, 2-2D, and S-4-7H) can effectively inhibit the binding between TeNT-Hc and differentiated PC-12 cells in vitro...
2016: Toxins
Hyun-Gyu Lee, Sundas Munir, Soo-Young Park
By utilizing a microfluidics approach, we prepared uniformly sized cholesteric liquid crystal (CLC) droplets from MLC-2132 doped with a chiral dopant (S)-4-cyano-4'-(2-methylbutyl)biphenyl (CB15). We studied the helical structures and reflecting color patterns of high- and low-dopant CLC droplets coated with poly(vinyl alcohol) (PVA) and sodium dodecyl sulfate (SDS). One central large spot with reflecting color in the CLC droplets (initially coated with PVA for planar anchoring) changed to many small spots with the same reflecting color (chicken-skin pattern) when an SDS aqueous solution was introduced to increase the homeotropic anchoring power...
October 5, 2016: ACS Applied Materials & Interfaces
Lan Li, Man Zhang, Yuting Wang, Wenhong Zhou, Zhiming Zhou
A simple procedure for the synthesis of three new oxazolinyl-substituted β-cyclodextrins (6-deoxy-6-R-(-)-4-phenyl-4,5-dihydrooxazolinyl-β-cyclodextrin, 6-deoxy-6-S-(-)-4-phenyl-4,5-dihydrooxazolinyl-β-cyclodextrin, and 6-deoxy-6-S-(-)-(4-pyridin-1-ium-4-methyl-benzenesulphonate)-4,5-dihy-drooxazolinyl-β-cyclodextrin) and their covalent bonding to silica are reported. The ability of these chiral stationary phase columns for separating compounds is also presented and discussed. Twenty-eight compounds were examined in the polar-organic mobile phase mode, and 11 β-nitroethanols were tested in the reversed-phase mode...
September 9, 2016: Journal of Separation Science
William D G Brittain, Brette M Chapin, Wenlei Zhai, Vincent M Lynch, Benjamin R Buckley, Eric V Anslyn, John S Fossey
The Bull-James boronic acid assembly is used simultaneously as a chiral auxiliary for kinetic resolution and as a chiral shift reagent for in situ enantiomeric excess (ee) determination by (1)H NMR spectroscopy. Chiral terminal alkyne-containing amines, and their corresponding chiral triazoles formed via CuAAC, were probed in situ. Selectivity factors of up to s = 4 were imparted and measured, accurate to within ±3% when compared to chiral GC.
September 6, 2016: Organic & Biomolecular Chemistry
Keiichi Yoshida, Yoshiaki Itoigawa, Yuichiro Maruyama, Yoshitomo Saita, Yuji Takazawa, Hiroshi Ikeda, Kazuo Kaneko, Tatsuo Sakai, Toru Okuwaki
INTRODUCTION: Muscle strain of the gastrocnemius medial head mainly occurs at the musculotendinous junction (MTJ), and stiffness is a risk factor. Shear wave elastography (SWE) measures elasticity by determining the propagation velocity. The aim of this study was to measure the elasticity of the normal muscle and aponeurosis in the MTJ of the gastrocnemius medial head using SWE, thus obtaining information relevant to muscle strain at this point. MATERIALS AND METHODS: Forty-one volunteers (82 legs) were recruited and the gastrocnemius medial heads were examined at four points: three on the aponeurosis, namely at the center of the MTJ (Central), 10 mm proximal to it (Proximal) and 10 mm distal to it (Distal); and at one on the muscle belly (Muscle)...
September 4, 2016: Clinical Anatomy
Hai-Sen Xu, San-Yuan Ding, Wan-Kai An, Han Wu, Wei Wang
Covalent organic frameworks (COFs) represent a new type of crystalline porous materials that are covalently assembled from organic building blocks. Construction of functional COFs is, however, a difficult task because it has to meet simultaneously the requirements for crystallinity and functionality. We report herein a facile strategy for the direct construction of chiral-functionalized COFs from chiral building blocks. The key design is to use the rigid scaffold 4,4'-(1H-benzo[d]imidazole-4,7-diyl)dianiline (2) for attaching a variety of chiral moieties...
September 14, 2016: Journal of the American Chemical Society
Maria Domercq, Boguslaw Szczupak, Jon Gejo, Vanessa Gómez-Vallejo, Daniel Padro, Kiran Babu Gona, Frédéric Dollé, Makoto Higuchi, Carlos Matute, Jordi Llop, Abraham Martín
In vivo Positron Emission Tomography (PET) imaging of the cystine-glutamate antiporter (system xc(-)) activity with [(18)F]FSPG is meant to be an attractive tool for the diagnosis and therapy evaluation of brain diseases. However, the role of system xc(-) in cerebral ischemia and its involvement in inflammatory reaction has been scarcely explored. In this work, we report the longitudinal investigation of the neuroinflammatory process following transient middle cerebral artery occlusion (MCAO) in rats using PET with [(18)F]FSPG and the translocator protein (TSPO) ligand [(18)F]DPA-714...
2016: Theranostics
Xavier Guitart, Jordi Bonaventura, William Rea, Marco Orrú, Lucrezia Cellai, Ilaria Dettori, Felicita Pedata, Marc Brugarolas, Antonio Cortés, Vicent Casadó, Ching-Pang Chang, Manikandan Narayanan, Yijuang Chern, Sergi Ferré
The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2AR) density or function in a rat model of Huntington disease (HD) with reported insensitivity to an A2AR antagonist. Unsuspected negative results led to the hypothesis of a low striatal adenosine tone and to the search for the mechanisms involved. Extracellular striatal concentrations of adenosine were measured with in vivo microdialysis in two rodent models of early neuropathological stages of HD disease, the Tg51 rat and the zQ175 knock-in mouse...
August 24, 2016: Neurobiology of Disease
Rita Megyesi, Enikő Forró, Ferenc Fülöp
Many alkaloids containing a tetrahydro-β-carboline skeleton have well-known therapeutic effects, leading to increased interest in the synthesis of these natural products. Enantiomers of N-Boc-protected 1-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline [(±)-7], 1-hydroxymethyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline [(±)-8], and 1-hydroxymethyl-6-fluoro-1,2,3,4-tetrahydro-β-carboline [(±)-9] were prepared through enzymecatalyzed asymmetric acylation of their primary hydroxyl group. The preliminary experiments were performed in a continuous-flow system, while the preparative-scale resolutions were done as batch reactions...
June 2016: ChemistryOpen
Laura Fernandes, Maria Madalena Centeno, Natacha Couto, Telmo Nunes, Virgílio Almeida, Lis Alban, Constança Pomba
Swine have been described as an important reservoir of multidrug resistant monophasic Salmonella Typhimurium, though information on its ecology is scarce. A longitudinal study was performed in order to elucidate the Salmonella 4,[5],12:i:- dynamics throughout the pig's production cycle. A total of 209 faecal samples were collected from 10 sows and in six sampling times during the life of 70 pigs from a Portuguese industrial farm, and 43 isolates of S. 4,[5],12:i:- were identified and characterized regarding clonality and antimicrobial resistance phenotype and genotype...
August 30, 2016: Veterinary Microbiology
Nicole E Chakov, Annaliese E Thuijs, Wolfgang Wernsdorfer, Arnold L Rheingold, Khalil A Abboud, George Christou
Three complexes are reported from the initial use of dimethylarsinic acid (Me2AsO2H) in Mn(III/IV) cluster chemistry, [Mn4O4(O2AsMe2)6] (3; 2Mn(III), 2Mn(IV)), and [Mn16X4O8(O2CPh)16(Me2AsO2)24] (X = Ca(2+) (4) or Sr(2+) (5); 16Mn(III)). They were obtained from reactions with [Mn12O12(O2CR)16(H2O)4] (R = Me, Ph) either without (3) or with (4 and 5) the addition of X(2+) salts. Complex 3 contains a [Mn4O4](6+) cubane, whereas isostructural 4 and 5 contain a planar loop structure comprising four Mn4 asymmetric "butterfly" units linked by alternating anti,anti μ-O2AsMe2 and {X2(O2AsMe2)(O2CPh)2} units...
September 6, 2016: Inorganic Chemistry
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