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Richard S E Keefe, George Nomikos, Wei Zhong, Michael Cronquist Christensen, William Jacobson
Background: We evaluated vortioxetine's effects on functional capacity in demographic and clinical subgroups of patients with major depressive disorder. Methods: This was an exploratory analysis of the CONNECT study (NCT01564862) that evaluated changes in functional capacity using University of California San Diego Performance-based Skills Assessment (UPSA) data, categorized by sex, age, education, employment status, and baseline disease severity (Montgomery-Åsberg Depression Rating Scale [MADRS], Clinical Global Impressions-Severity of Illness [CGI-S])...
March 12, 2018: International Journal of Neuropsychopharmacology
A H Reshak
Comprehensive ab initio calculations from first- to second-principles methods are performed to investigate the suitability of non-centro-symmetric CdLa2 S4 and CdLa2 Se4 to be used as active photocatalysts under visible light illumination. The calculations reveal the direct band gap nature of both compounds with large absorption coefficients (104 -105 cm-1 ). The absorption edges of CdLa2 S4 and CdLa2 Se4 occur at λ = 579.3 nm and λ = 670.1 nm, and the optical band gaps are estimated to be 2.14 eV and 1.85 eV for CdLa2 S4 and CdLa2 Se4 , respectively...
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
R Draganova, A Schollbach, F Schleger, J Braendle, S Brucker, H Abele, K O Kagan, D Wallwiener, A Fritsche, H Eswaran, H Preissl
The human fetal auditory system is functional around the 25th week of gestational age when the thalamocortical connections are established. Fetal magnetoencephalography (fMEG) provides evidence for fetal auditory brain responses to pure tones and syllables. Fifty-five pregnant women between 31 and 40 weeks of gestation were included in the study. Fetal MEG was recorded during the presentation of an amplitude modulated tone (AM) with a carrier frequency of 500 Hz to the maternal abdomen modulated by low modulation rates (MRs) - 2/s and 4/s, middle MR - 8/s and high MRs - 27/s, 42/s, 78/s and 91/s...
March 6, 2018: Hearing Research
Mahadeo A Mahadik, Pravin S Shinde, Hyun Hwi Lee, Min Cho, Jum Suk Jang
This data article presents the experimental evidences of the effect of TiO2 -fluorine doped tin oxide interface annealing and Ni(OH)2 cocatalysts on the photoelectrochemical, structural, morphological and optical properties of Ni(OH)2 /CdS/ZnIn2 S4 /TiO2 heterojunction. The Raman spectroscopy exhibits the sharp features of the rutile phase of TiO2 and in agreement with the X-ray diffraction data. The band gap energy of the 500 °C sample was found to be 3.12 eV, further it was increased to 3.20, 3.22 eV for samples annealed at 600 and 700 °C respectively...
April 2018: Data in Brief
María Eva González-Trujano, Gerardo Uribe-Figueroa, Sergio Hidalgo-Figueroa, Ana Laura Martínez, Myrna Déciga-Campos, Gabriel Navarrete-Vazquez
The aim of this work was to design, synthesize and characterize the potential anti-nociceptive and anti-inflammatory activities of a new series of bioisosteres and hybrids from known non-steroidal anti-inflammatory drugs (NSAIDs). The compounds 4-(acetylamino)phenyl (2S)-2-(6-methoxy-2-naphthyl)propanoate (GUF-1) and 4-(acetylamino)phenyl 2-(R,S)-(4-isobutylphenyl)propanoate (GUF-2) were synthesized as hybrids (also known as heterodimers); whereas those named 2-(R,S)-(4-isobutylphenyl)-N-1H-tetrazol-5-ylpropanamide (GUF-3), (2S)-2-(6-methoxy-2-naphthyl)-N-1H-tetrazol-5-ylpropanamide (GUF-4), [2-(R,S)-N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide] (GUF-5), and (2S)-N-hydroxy-2-(6-methoxy-2-naphthyl)propanamide (GUF-6) were synthesized as bioisosteres of the NSAIDs paracetamol, ibuprofen, and naproxen, respectively...
March 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Y Jiao, J D Wang, J P Deng
OBJECTIVE: To investigate the effects of 3 surface different treatments on the crystal structure, shear bond strength,roughness value and flexural strength of zirconia. METHODS: The zirconia specimens were prepared and randomly divided into 4 groups and received the following treatments: (1) blank control group,the specimens without treatments; (2)sandblasting with alumina group, sandblasting the specimens with 110 μm alumina particles for 21 s as working pressure 0...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Stephan Rodrigo Marticorena Garcia, Markus Grossmann, Sophia Theresa Lang, Manh Nguyen Trong, Michael Schultz, Jing Guo, Bernd Hamm, Jürgen Braun, Ingolf Sack, Heiko Tzschätzsch
The purpose of this study was to analyze full-field-of-view maps of renal shear wave speed (SWS) measured by time-harmonic elastography (THE) in healthy volunteers in terms of reproducibility, regional variation and physiologic effects. The kidneys of 37 healthy volunteers were investigated by multifrequency THE. The complete renal parenchyma, as well as cortex and medulla, was analyzed. A subgroup was investigated to test reproducibility (n = 3). Significant differences between SWS in cortex, medulla and full parenchyma were observed (2...
February 22, 2018: Ultrasound in Medicine & Biology
Jason B Hedges, Eugene Kuatsjah, Yi-Ling Du, Lindsay D Eltis, Katherine S Ryan
Enzymes that catalyze hydroxylation of unactivated carbons normally contain heme- and non-heme iron cofactors. By contrast, how a pyridoxal phosphate (PLP)-dependent enzyme could catalyze such a hydroxylation was unknown. Here, we investigate RohP, a PLP-dependent enzyme that converts L-arginine to (S)-4-hydroxy-2-ketoarginine. We determine that the RohP reaction consumes oxygen, with stoichiometric release of H2 O2 . To understand this unusual chemistry, we obtain ~1.5 Å resolution structures that capture intermediates along the catalytic cycle...
February 21, 2018: ACS Chemical Biology
Xinglong Tu, Jing Lu, Ming Li, Yanjie Su, Guilin Yin, Dannong He
Hierarchically ZnIn2 S4 nanosheet-constructed microwire arrays (NCMAs) on a zinc substrate have been synthesized for the first time through a one-step solvothermal method without using any template or surfactant. The as-synthesized ZnIn2 S4 microwires are constructed by vertical nanosheets preferentially exposing (006) facets, which are about 1-5 μm in diameters and larger than 10 μm in average length. Experimental results demonstrate that the hierarchically ZnIn2 S4 NCMAs are converted from intermediate components of single crystalline indium nanowires, which are generated along the direction of (101) planes by a displacement reaction between Zn and In3+ during the initial synthesis process...
February 21, 2018: Nanoscale
Martin Schoenthaler, Karl-Dietrich Sievert, Dominik Stefan Schoeb, Arkadiusz Miernik, Thomas Kunit, Simon Hein, Thomas R W Herrmann, Konrad Wilhelm
PURPOSE: The aim of the study was to evaluate the feasibility and safety of combining prostatic urethral lift (PUL) and a limited resection of the prostatic middle lobe or bladder neck incision in the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). METHODS: Twenty-eight patients were treated at two tertiary centers and followed prospectively. Patient evaluations included patient characteristics, relief of LUTS symptoms, erectile and ejaculatory function, continence, operative time and adverse events...
February 15, 2018: World Journal of Urology
Liangli Cao, Yuren Jiang, Zhencheng Chen
In the present research an attempt was made to develop and optimize rapamycin (Rapa) loaded hollow magnetic Fe3O4/graphene oxide (Fe3O4/GO) nanocomposites using solvent evaporation technique and response surface methodology (RSM). A Box-Behnken design (BBD) with a three-level, three-factor was used to determine preparation parameters that would achieve the highest encapsulation efficiency (EE) and drug loading capacity (DLC). At optimum conditions such as mass ratio of Rapa to Fe3O4/GO (Rapa: Fe3O4/GO) 0.45, oscillation rate 144...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Isabel Hottmann, Valentina M T Mayer, Markus B Tomek, Valentin Friedrich, Matthew B Calvert, Alexander Titz, Christina Schäffer, Christoph Mayer
Tannerella forsythia is an anaerobic, Gram-negative oral pathogen that thrives in multispecies gingival biofilms associated with periodontitis. The bacterium is auxotrophic for the commonly essential bacterial cell wall sugar N-acetylmuramic acid (MurNAc) and, thus, strictly depends on an exogenous supply of MurNAc for growth and maintenance of cell morphology. A MurNAc transporter (Tf_MurT; Tanf_08375) and an ortholog of the Escherichia coli etherase MurQ (Tf_MurQ; Tanf_08385) converting MurNAc-6-phosphate to GlcNAc-6-phosphate were recently described for T...
2018: Frontiers in Microbiology
Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
Currently used antipsychotics are characterized by multireceptor mode of action. While antagonism of dopamine D2 receptors is responsible for the alleviation of "positive" symptoms of schizophrenia and the effects at other, particularly serotonergic receptors are necessary for their additional therapeutic effects, there is no consensus regarding an "ideal" target engagement. Here, a detailed SAR analysis in a series of 45 novel azinesulfonamides of cyclic amine derivatives, involving the aryl-piperazine/piperidine pharmacophore, central alicyclic amine and azinesulfonamide groups has led to the selection of (S)-4-((2-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)isoquinoline (62)...
February 10, 2018: European Journal of Medicinal Chemistry
Qin Zhou, Long Wang, Xi Wang, Qiong Xiong, Yanian Wei, Song Dang, Liang Zhong
OBJECTIVE: To explore the protective effect of neuregulin-1 (NRG-1) on heart function and myocardium in rats with sepsis and its mechanism. METHODS: Healthy male Sprague-Dawly (SD) rats were divided into three groups according to random number table method, with 6 rats in each group. Sepsis model was established by cecal ligation and puncture (CLP group); rats in sham operation group (sham group) underwent the same procedure except ligation. Rats in NRG-1 pre-treatment group (NRG group) were intravenously injected with recombinant human NGR-1 (rhNRG-1) at the dose of 10 μg/kg through tail vein; rats in CLP group and sham group were treated with the same amount of saline...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Kelly A Durbin, David Clewett, Ringo Huang, Mara Mather
When faced with threat, people often selectively focus on and remember the most pertinent information while simultaneously ignoring any irrelevant information. Filtering distractors under arousal requires inhibitory mechanisms, which take time to recruit and often decline in older age. Despite the adaptive nature of this ability, relatively little research has examined how both threat and time spent preparing these inhibitory mechanisms affect selective memory for goal-relevant information across the life span...
February 1, 2018: Emotion
Yi Ning, Zhiming Zhang, Feng Teng, Xiaosheng Fang
A novel self-powered UV photodetector based on electrospun ZnO nanofiber arrays is introduced. Aligned pure ZnO nanofibers and Ag-doped p-type ZnO nanofibers are processed perpendicular to each other, and p-n junction arrays of ZnO nanofibers are fabricated as a result. Owing to the intrinsic intervals between nanofibers, the device is fully transparent on quartz substrate. Various characterization methods including TEM, XRD, and XPS are used to testify the existence form of Ag element in ZnO nanofibers, and a field effect transistor is constructed to judge their conductivity...
January 31, 2018: Small
Paul S Sung, Pamela Danial
Postural responses following slip perturbations are critical to fall prevention strategies. It is unclear how postural reactions with a handheld task can validly be transferred to treadmill-induced slip perturbations in subjects with recurrent low back pain (LBP). The purpose of this study was to investigate trunk reaction times and trunk flexion angle as well as velocity following the slips between subjects with and without LBP. There were 29 subjects with LBP and 40 control subjects who participated in the study...
January 25, 2018: Annals of Biomedical Engineering
Marc Jambon, Judith G Smetana
Drawing on the framework of social domain theory, this multi-method, multi-informant longitudinal study examined whether callous-unemotional (CU) tendencies moderated the association between U.S. 4 to 7 year olds' (n = 135; Mage = 5.65, 50% male; 75% White) ability to differentiate hypothetical, prototypical moral and conventional transgressions along theoretical criteria and teacher (n = 49) and parent (n = 128, 91% mothers) ratings of physical aggression. Deficits in domain distinction ability were associated with greater teacher-reported aggression both concurrently and 9 months later, but only for children high in CU traits...
January 22, 2018: Developmental Psychology
Mehrez Hammami, Nawel Gaamouri, Roy J Shephard, Mohamed Souhaiel Chelly
The aim was to compare the effects of two differing 8-week in-season strength training programs (contrast strength training [CST] vs. plyometric training [PT]) on selected performance tests (5 and 40m sprints, S 4 X 5 m change of direction test, squat (SJ) and countermovement (CMJ) jumps , leg peak power on a cycle ergometer force-velocity test, 1-repetition maximal (1-RM) half squat, and electromyographic [EMG] activity of the vastus lateralis, vastus medialis and rectus femoris muscles during vertical jump tests)...
January 17, 2018: Journal of Strength and Conditioning Research
(no author information available yet)
In 2016, 51.5% of adult day services center participants lived in a private residence with relative(s), 19.9% lived alone in a private residence, 16.3% lived in an assisted living/residential care community, 5.3% lived in a private residence with nonrelative(s), 4.5% had another living arrangement, and 1.5% lived in a nursing home.
January 19, 2018: MMWR. Morbidity and Mortality Weekly Report
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