Elder Sales da Silva, Patrícia Maria Ferreira, Carlos Henrique Castro, Lilian Fernanda Pacheco, Daniel Graziani, Carolina Nobre Ribeiro Pontes, Amanda de Sá Martins de Bessa, Erika Fernandes, Lara Marques Naves, Larissa Cristina Dos Santos Ribeiro, Michelle Mendanha Mendonça, Rodrigo Mello Gomes, Gustavo Rodrigues Pedrino, Reginaldo Nassar Ferreira, Carlos Henrique Xavier
Ghrelin is a peptide hormone whose effects are mediated by the growth hormone secretagogue receptor subtype 1a (GHS-R1a), mainly expressed in the brain but also in kidneys. The hypothesis herein raised is that GHS-R1a would be player in the renal contribution to the neurogenic hypertension pathophysiology. To investigate GHS-R1a role on renal function and hemodynamics, we used Wistar (WT) and spontaneously hypertensive rats (SHR). First, we assessed the effect of systemically injected vehicle, ghrelin, GHS-R1a antagonist PF04628935, ghrelin plus PF04628935 or GHS-R1a synthetic agonist MK-677 in WT and SHR rats housed in metabolic cages (24 h)...
December 1, 2020: Molecular and Cellular Endocrinology