Furkan Bestepe, George F Ghanem, Colette M Fritsche, James Weston, Sumedha Sahay, Amanda K Mauro, Parul Sahu, Sude M Tas, Brooke Ruemmele, Sarah Persing, Miranda E Good, Abhishek Chatterjee, Gordon S Huggins, Payam Salehi, Basak Icli
Wound healing is facilitated by neoangiogenesis, a complex process that is essential to tissue repair in response to injury. MicroRNAs are small, noncoding RNAs that can regulate the wound healing process including stimulation of impaired angiogenesis that is associated with type-2 diabetes (T2D). Expression of miR-409-3p was significantly increased in the nonhealing skin wounds of patients with T2D compared to the non-wounded normal skin, and in the skin of a murine model with T2D. In response to high glucose, neutralization of miR-409-3p markedly improved EC growth and migration in human umbilical vein endothelial cells (HUVECs), promoted wound closure and angiogenesis as measured by increased CD31 in human skin organoids, while overexpression attenuated EC angiogenic responses...
February 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology