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https://www.readbyqxmd.com/read/28103265/rabbit-model-of-human-gliomas-implications-for-intra-arterial-drug-delivery
#1
Huamin Qin, Miroslaw Janowski, Monica S Pearl, Izabela Malysz-Cymborska, Shen Li, Charles G Eberhart, Piotr Walczak
The prognosis for malignant brain tumors remains poor despite a combination of surgery, radiotherapy, and chemotherapy. This is partly due to the blood-brain barrier, a major obstacle that prevents therapeutic agents from effectively reaching the tumor. We have recently developed a method for precise and predictable opening of the blood-brain barrier via the intra-arterial administration of mannitol, a hyperosmolar agent, in a rabbit model, whose vascular anatomy facilitates the use of standard interventional neuroradiology techniques and devices...
2017: PloS One
https://www.readbyqxmd.com/read/28081152/increased-serum-sodium-and-serum-osmolarity-are-independent-risk-factors-for-developing-chronic-kidney-disease-5-year-cohort-study
#2
Masanari Kuwabara, Ichiro Hisatome, Carlos A Roncal-Jimenez, Koichiro Niwa, Ana Andres-Hernando, Thomas Jensen, Petter Bjornstad, Tamara Milagres, Christina Cicerchi, Zhilin Song, Gabriela Garcia, Laura G Sánchez-Lozada, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson
BACKGROUND: Epidemics of chronic kidney disease (CKD) not due to diabetes mellitus (DM) or hypertension have been observed among individuals working in hot environments in several areas of the world. Experimental models have documented that recurrent heat stress and water restriction can lead to CKD, and the mechanism may be mediated by hyperosmolarity that activates pathways (vasopressin, aldose reductase-fructokinase) that induce renal injury. Here we tested the hypothesis that elevated serum sodium, which reflects serum osmolality, may be an independent risk factor for the development of CKD...
2017: PloS One
https://www.readbyqxmd.com/read/28046026/comparison-of-in-vitro-and-ex-vivo-wound-healing-assays-for-the-investigation-of-diabetic-wound-healing-and-demonstration-of-a-beneficial-effect-of-a-triterpene-extract
#3
Christopher Ueck, Thomas Volksdorf, Pia Houdek, Sabine Vidal-Y-Sy, Susanne Sehner, Bernhard Ellinger, Ralf Lobmann, Axel Larena-Avellaneda, Konrad Reinshagen, Ina Ridderbusch, Klaas Kohrmeyer, Ingrid Moll, Rolf Daniels, Philipp Werner, Irmgard Merfort, Johanna M Brandner
Diabetes mellitus is a frequent cause for chronic, difficult-to-treat wounds. New therapies for diabetic wounds are urgently needed and in-vitro or ex-vivo test systems are essential for the initial identification of new active molecules. The aim of this study is to compare in-vitro and ex-vivo test systems for their usability for early drug screening and to investigate the efficacy of a birch bark triterpene extract (TE) that has been proven ex-vivo and clinically to accelerate non-diabetic wound healing (WH), in a diabetic context...
2017: PloS One
https://www.readbyqxmd.com/read/27974984/technical-innovation-case-report-ultrasound-guided-prolotherapy-injection-for-insertional-achilles-calcific-tendinosis
#4
Benjamin K Buchanan, Jesse P DeLuca, Kyle P Lammlein
We describe the use of ultrasound guidance for hyperosmolar dextrose (prolotherapy) injection of the distal calcaneal tendon specifically just anterior to identified enthesophytes in patients with insertional Achilles calcific tendinosis refractory to conservative treatment. This specific technique has not to our knowledge been described or used in literature previously.
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27941330/hyperosmolarity-and-benzalkonium-chloride-differently-stimulate-inflammatory-markers-in-conjunctiva-derived-epithelial-cells-in-vitro
#5
Elise Warcoin, Chloé Clouzeau, Christophe Roubeix, Anne-Laure Raveu, David Godefroy, Luisa Riancho, Christophe Baudouin, Françoise Brignole-Baudouin
Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva could give new insights into the effect of this preservative on the disease. In a hyperosmolar model on a conjunctiva-derived cell line, and in the presence of BAK, we evaluated key inflammatory markers [CCL2, IL-8, IL-6, macrophage migration inhibitory factor (MIF) and intercellular adhesion molecule (ICAM)-1] as well as the osmoprotectant element nuclear factor of activated T cells (NFAT)5 using ELISA, RT-qPCR or immunofluorescence staining...
December 10, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27928967/hot-topics-in-dry-eye-disease
#6
Pablo Alberto Chiaradia, Luis Alberto Zeman Bardeci, Sebastián Dankert, Marcos Omar Mendaro, Andrzej Grzybowski
BACKGROUND: Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that results in symptoms such as discomfort, visual disturbance, and tear film instability, with potential damage to the ocular surface. The principal pathological mechanisms of DED are hyperosmolarity and inflammation. These mechanisms are deeply interrelated and lead to a self-perpetuating "vicious circle". METHODS: The objective of this review is to describe novel pharmacological and non-pharmacological treatments for DED...
December 7, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27924173/predictors-of-recurrent-hospital-admission-for-patients-presenting-with-diabetic-ketoacidosis-and-hyperglycemic-hyperosmolar-state
#7
Annabel L Bradford, Courtney Champagne Crider, Xizheng Xu, Syed Hasan Naqvi
BACKGROUND: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two serious, preventable complications of diabetes mellitus. Analysis of variables associated with recurrent DKA and HHS admission has the potential to improve patient outcomes by identifying possible areas for intervention. The aim of this study was to evaluate potential predictors of recurrent DKA or HHS admission. METHODS: This was a retrospective case-control study of 367 patients presenting during a 5-year period with DKA or HHS at a US tertiary academic medical center...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27913232/visual-acuity-and-quality-of-life-in-dry-eye-disease-proceedings-of-the-ocean-group-meeting
#8
José Benítez-Del-Castillo, Marc Labetoulle, Christophe Baudouin, Maurizio Rolando, Yonca A Akova, Pasquale Aragona, Gerd Geerling, Jesús Merayo-Lloves, Elisabeth M Messmer, Kostas Boboridis
Dry eye disease (DED) results in tear film instability and hyperosmolarity, inflammation of the ocular surface and, ultimately, visual disturbance that can significantly impact a patient's quality of life. The effects on visual acuity result in difficulties with driving, reading and computer use and negatively impact psychological health. These effects also extend to the workplace, with a loss of productivity and quality of work causing substantial economic losses. The effects of DED and the impact on vision experienced by patients may not be given sufficient importance by ophthalmologists...
November 29, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27896327/a-case-of-mediastinitis-accompanied-with-hyperosmolar-nonketotic-coma
#9
Mazhar Muslum Tuna, Faruk Kilinc, Zafer Pekkolay, Hikmet Soylu, Alpaslan Kemal Tuzcu
Mediastinitis is a serious infection involving mediastinal spaces after cervical infections spread along the facial planes. A late diagnosis of mediastinitis may result in death. Here we present a diabetic patient suffered from mediastinit accompanied with hyperosmolar nonketotic coma. A 61 years old male patient with type 2 diabetes was admitted to our hospital, with complaint of generalized worsening and fever. A diagnosis of nonketotic hyperosmolar coma was done and proper treatment started immediately. Neck tomography revealed abscess formation in the upper mediastinum...
June 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27890860/renal-denervation-by-ct-guided-periarterial-injection-of-hyperosmolar-saline-vincristine-paclitaxel-and-guanethidine-in-a-pig-model
#10
Patrick Freyhardt, Ricardo Donners, Alex Riemert, Jörg Schnorr, Nicola Stolzenburg, Jan Leo Rinnenthal, Ulrich Bernhardt, Bernd Hamm, Rolf W Günther, Florian Streitparth
AIMS: To evaluate feasibility, safety and efficacy of renal sympathetic denervation with CT- guided periarterial injection of potentially neurolytic agents in pigs. METHODS AND RESULTS: Unilateral injection of formulations containing either 5 M hyperosmolar saline, vincristine, paclitaxel or guanethidine around the renal artery was performed in 24 normotensive pigs with 6 animals per group. Needle placement and injections were performed under CT-fluoroscopy guidance...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27878040/effect-of-contrast-media-on-urinary-cytopathology-specimens
#11
Sebastian Frees, Samir Bidnur, Michael Metcalfe, Peter Raven, Claudia Chavez-Munoz, Igor Moskalev, Ladan Fazli, Alan So
INTRODUCTION: Urological dogma dictates that washings collected from the urinary tract for cytological assessment must be performed without interference from contrast agents that may alter cellular integrity and diagnostic interpretation. In practice, the initial contrast used to outline the upper tracts is commonly discarded with subsequent saline washings sent for cytology. We hypothesize that contrast washings do not affect the morphology of urothelial carcinoma cells or the integrity of cytology interpretation...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27875539/secular-trends-in-admissions-and-mortality-rates-from-diabetes-mellitus-in-the-central-belt-of-ghana-a-31-year-review
#12
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Benjamin Eghan, Nana Kwame Ayisi-Boateng, Emmanuel Acheamfour-Akowuah
INTRODUCTION: Diabetes Mellitus is currently a leading cause of morbidity and mortality throughout the world, particularly in sub-Saharan Africa where a significant proportion of diabetes cases are now found. Longitudinal profiling of in-patient admissions and mortality trends from diabetes provide useful insights into the magnitude of the burden of diabetes, serve as a sentinel on the state of out-patient diabetes care and provide effective tools for planning, delivering and evaluating the health care needs relating to the disease in sub-Saharan Africa...
2016: PloS One
https://www.readbyqxmd.com/read/27875309/rna-sequencing-reveals-a-role-of-tonebp-transcription-factor-in-regulation-of-pro-inflammatory-genes-in-response-to-hyperosmolarity-in-healthy-nucleus-pulposus-cells-a-homeostatic-response
#13
Zariel I Johnson, Irving M Shapiro, Makarand V Risbud
Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche. Recent studies implicate TonEBP signaling in inflammatory disease and rheumatoid arthritis pathogenesis. However, broader functions of TonEBP in the disc remain unknown. RNA sequencing was performed on NP cells with TonEBP knockdown under hypertonic conditions. 1140 TonEBP-dependent genes were identified and categorized using Ingenuity Pathway Analysis...
December 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27863115/reversible-splenial-lesion-syndrome-with-a-hyperosmolar-hyperglycemic-state-and-neuroleptic-malignant-syndrome-caused-by-olanzapine
#14
Kenta Kaino, Ryo Kumagai, Shoko Furukawa, Momoko Isono, Aiko Muramatsu, Masanao Fujii, Yumiko Muta, Tomoyuki Asada, Kazuya Fujihara, Hiroaki Yagyu
A 27-year-old woman with panic disorder taking 20 mg olanzapine daily for 4 months was admitted to our hospital because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity, and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state (HHS) and neuroleptic malignant syndrome (NMS). Brain magnetic resonance imaging (MRI) showed transiently restricted diffusion in the splenium of the corpus callosum (SCC), with a high signal intensity on diffusion-weighted imaging...
November 18, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27861271/extreme-hyperglycemia-and-hyperosmolar-hyperglycemic-syndrome
#15
Susan J Appel
No abstract text is available yet for this article.
December 16, 2016: Nurse Practitioner
https://www.readbyqxmd.com/read/27852737/role-of-fructose-and-fructokinase-in-acute-dehydration-induced-vasopressin-gene-expression-and-secretion-in-mice
#16
Zhilin Song, Carlos A Roncal-Jimenez, Miguel A Lanaspa-Garcia, Sarah A Oppelt, Masanari Kuwabara, Thomas Jensen, Tamara Milagres, Ana Andres-Hernando, Takuji Ishimoto, Gabriela E Garcia, Ginger C Johnson, Paul S MacLean, Laura-Gabriela Sanchez-Lozada, Dean R Tolan, Richard J Johnson
BACKGROUND: Fructose stimulates vasopressin in humans and can be generated endogenously by activation of the polyol pathway with hyperosmolarity. We hypothesized that fructose metabolism in the hypothalamus might partly control vasopressin responses after acute dehydration. METHODS: Wildtype and fructokinase-knockout mice were deprived of water for 24 hours. The supraoptic nucleus was evaluated for vasopressin and the aldose reductase-fructokinase pathway. The posterior pituitary vasopressin and serum copeptin levels were examined...
November 16, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27851592/1958-unique-survival-story-of-hyperosmolar-coma-due-to-huge-co-ingestion-of-ethylene-glycol-and-ethanol
#17
Jessita S Natasha Albert Messiah Dhas, Raghad Hussein, Mohammed Mogri, Lokendra Thakur
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851450/1815-opsoclonus-a-rare-and-interesting-neurologic-manifestation-of-hyperosmolar-hyperglycemic-state
#18
Shyam Shankar, Hatem Desoky, Ishan Malhotra, Mangalore Amith Shenoy, Anand Kumar Rai, Benhoor Shamian, Yizhak Kupfer
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836573/human-mesenchymal-stromal-cells-undergo-apoptosis-and-fragmentation-after-intravenous-application-in-immune-competent-mice
#19
Johannes Leibacher, Katrin Dauber, Sabrina Ehser, Veronika Brixner, Katarina Kollar, Anja Vogel, Gabi Spohn, Richard Schäfer, Erhard Seifried, Reinhard Henschler
BACKGROUND AIMS: The biodistribution of human MSCs after systemic delivery is incompletely understood. We investigated the changes in cell size and cell surface markers of human MSCs after intravenous (IV) injection in immune competent mice. METHODS: Male human MSCs were labeled with fluorescent vital dye PKH67 and tracked after IV administration in C57/BL6 mice. MSCs were tracked in blood and different murine tissues by human SRY gene quantitative polymerase chain reaction (qPCR) analysis, flow cytometry and fluorescence microscopy...
January 2017: Cytotherapy
https://www.readbyqxmd.com/read/27807609/osmolality-of-enteral-formula-and-severity-of-experimental-necrotizing-enterocolitis
#20
Hiromu Miyake, Yong Chen, Yuhki Koike, Alison Hock, Bo Li, Carol Lee, Augusto Zani, Agostino Pierro
PURPOSE: Administration of hyperosmolar formula is regarded as a risk factor for the development of necrotizing enterocolitis (NEC). However, there are limited number of reports about the relationship between formula osmolality and NEC. The aim of this study is to evaluate the effects of formula concentration in an experimental model of NEC. METHODS: We studied experimental NEC in C57BL/6 mice. NEC was induced by giving hypoxia, gavage administration of lipopolysaccharide and gavage formula feeding from postnatal day 5-9...
December 2016: Pediatric Surgery International
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