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beta catenin and cervical cancer

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https://www.readbyqxmd.com/read/25450584/the-role-of-signaling-pathways-in-cervical-cancer-and-molecular-therapeutic-targets
#1
REVIEW
Joaquín Manzo-Merino, Adriana Contreras-Paredes, Elenaé Vázquez-Ulloa, Leticia Rocha-Zavaleta, Alma M Fuentes-Gonzalez, Marcela Lizano
Cervical cancer is a public health issue in developing countries. Although the Pap smear and colposcopy remain the major strategies for detection, most cases are diagnosed in the late stages. Therefore, a major concern has been to develop early diagnostic approaches and more effective treatments. Molecular pathways that participate in cervical malignant transformation have emerged as promising directed therapeutic targets. In this review, we explore some of the major pathways implicated in cervical cancer development, including RAF/MEK/ERK, phosphatidylinositol-3 kinase (PI3K/AKT), Wnt/b-catenin, apoptosis and coupled membrane receptor signaling...
October 2014: Archives of Medical Research
https://www.readbyqxmd.com/read/25348322/generation-of-k14-e7-%C3%A2-n87%C3%AE-cat-double-transgenic-mice-as-a-model-of-cervical-cancer
#2
Gülay Bulut, Aykut Üren
Nearly all cervical cancers are initiated by a subset of high-risk human papilloma viruses (HPVs). However, cervical cancers develop only in a small fraction of women who are infected with these viruses. HPV is required, but not sufficient for developing cervical cancer. Activation of complementary signaling pathways appears to be necessary for malignant transformation of cervical epithelial cells that are immortalized by HPV. Here, we describe the creation and maintenance of a double transgenic mouse model that is based on constitutively active Wnt/β-catenin signaling in cervical epithelial cells expressing the HPV oncoprotein E7...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/25193857/lgr5-promotes-the-proliferation-and-tumor-formation-of-cervical-cancer-cells-through-the-wnt-%C3%AE-catenin-signaling-pathway
#3
Qing Chen, Hao-Zhe Cao, Peng-Sheng Zheng
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a seven transmembrane receptor known as a potential stem cell marker for intestinal crypts and hair follicles, has recently been found to be overexpressed in some types of human cancers. However, the role of LGR5 in cervical cancer remains unclear. In this study, the expression of LGR5 gradually increases from normal cervix to cervical cancer in situ and to cervical cancers as revealed by immunohistochemistry and western blot analyses. Through knocking down or overexpressing LGR5 in SiHa and HeLa cells, the expression level of LGR5 was found to be positively related to cell proliferation in vitro and to tumor formation in vivo...
October 15, 2014: Oncotarget
https://www.readbyqxmd.com/read/25168372/role-of-epithelial-to-mesenchymal-transition-proteins-in-gynecological-cancers-pathological-and-therapeutic-perspectives
#4
REVIEW
Xiao-Mei Zhou, Hai Zhang, Xia Han
Gynecorelogic cancers like ovarian, cervical, and endometrial cancers are among the major threats to modern life, especially to female health. Like some other types of cancers, all of these gynecological cancers have found to be associated with the developmental stage epithelial to mesenchymal transition (EMT). More specifically, the aberrant expression of major EMT markers, such as lower expressions of E-cadherin and alpha-catenin, and overexpressions of N-cadherin, beta-catenin, vimentin, and matrix metalloproteinases, have been reported in ovarian, cervical, and endometrial cancers...
October 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25120767/nuclear-localizaiton-of-%C3%AE-catenin-is-associated-with-poor-survival-and-chemo-radioresistance-in-human-cervical-squamous-cell-cancer
#5
Yanna Zhang, Bangzhong Liu, Qingyu Zhao, Teng Hou, Xin Huang
Nuclear expression of β-catenin has been suggested as an independent prognostic marker in a variety of cancers. The objective of this study was to investigate the clinicopathologic significance of nuclear β-catenin expression in patients with cervical squamous cell carcinoma (CSCC). In this original research article, we detected nuclear β-catenin expression in 29/171 CSCC tissues (17.0%). Patients without nuclear β-catenin expression had a significantly better outcome than patients with nuclear β-catenin expression (93...
2014: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25081282/glucose-regulated-protein-58-modulates-%C3%AE-catenin-protein-stability-in-a-cervical-adenocarcinoma-cell-line
#6
Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chyong-Huey Lai, Shih-Ming Jung, Chuen Hsueh, Kwang-Huei Lin
BACKGROUND: Cervical cancer continues to threaten women's health worldwide, and the incidence of cervical adenocarcinoma (AD) is rising in the developed countries. Previously, we showed that glucose-regulated protein 58 (Grp58) served as an independent factor predictive of poor prognosis of patients with cervical AD. However, the molecular mechanism underlying the involvement of Grp58 in cervical carcinogenesis is currently unknown. METHODS: DNA microarray and enrichment analysis were used to identify the pathways disrupted by knockdown of Grp58 expression...
2014: BMC Cancer
https://www.readbyqxmd.com/read/25018014/microrna%C3%A2-10a-enhances-the-metastatic-potential-of-cervical-cancer-cells-by-targeting-phosphatase-and-tensin-homologue
#7
Tianhe Zeng, Guiling Li
Cervical cancer is one of the leading causes of cancer‑related mortality worldwide. Previously, the upregulation of microRNA (miR)‑10a has been identified in human cervical cancer. The present study firstly demonstrated that miR‑10a was markedly upregulated in primary tumor tissues in patients with positive lymph node metastasis (LN+) compared with negative (LN‑) by quantitative polymerase chain reaction. miR‑10a mimics markedly enhanced cervical cancer cell migration and invasion abilities, and accordingly the miR‑10a inhibitor suppressed those functions...
September 2014: Molecular Medicine Reports
https://www.readbyqxmd.com/read/24715170/peptidyl-prolyl-isomerase-pin1-mediated-abrogation-of-apc-%C3%AE-catenin-interaction-in-squamous-cell-carcinoma-of-cervix
#8
Poonam Jawanjal, Sudha Salhan, Indrani Dhawan, Richa Tripathi, Gayatri Rath
OBJECTIVE: The present study was aimed to investigate the importance of Pin1 expression in Squamous Cell Carcinoma (SCC) of cervix and to assess its level with β-catenin and APC to understand the possible involvement of Pin1 in the regulation of these proteins and subsequent activation of Wnt/β-catenin signaling. MATERIALS AND METHODS: Expression of Pin1, β-catenin and APC was examined in 153 SCC patients by immunohistochemistry and revalidated by western blotting...
2014: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/24503442/mir-135a-leads-to-cervical-cancer-cell-transformation-through-regulation-of-%C3%AE-catenin-via-a-siah1-dependent-ubiquitin-proteosomal-pathway
#9
Carmen O N Leung, Wen Deng, Tian-Min Ye, Hextan Y S Ngan, Sai Wah Tsao, Annie N Y Cheung, Ronald T K Pang, William S B Yeung
Human papillomaviruses (HPVs) is the principal etiological agent of cervical cancer (CC). However, exposure to the high-risk type HPV alone is insufficient for tumor formation, and additional factors are required for the HPV-infected cells to become tumorigenic. Dysregulated microRNAs (miRNAs) expression is frequently observed in cancer but their roles in the formation of CC have not been fully revealed. In this study, we compared the expression of miR-135a in laser capture microdissected cervical specimens and confirmed overexpression of the miRNA in malignant cervical squamous cell carcinoma compared with precancerous lesions...
September 2014: Carcinogenesis
https://www.readbyqxmd.com/read/24337893/allograft-inflammatory-factor-1-is-an-independent-prognostic-indicator-that-regulates-%C3%AE-catenin-in-gastric-cancer
#10
Yang Ye, Shuhan Miao, Rongzhu Lu, Xiaowei Xia, Yansu Chen, Jianbing Zhang, Xuming Wu, Song He, Fulin Qiang, Jianwei Zhou
Previous studies have revealed that expression of allograft inflammatory factor-1 (AIF-1) protein appears to be increased in malignancies and is correlated with a poorer prognosis in cervical cancer, while its role in gastric cancer has not been reported. We analyzed the expression of AIF-1 in 78 cancer lesions and the corresponding non-cancerous tissues by immunohistochemistry. In contrast with other cancers, we found that AIF-1 protein levels were significantly decreased in 53 of the 78 (67.9%) gastric cancer tissues when compared with the matched normal tissues...
February 2014: Oncology Reports
https://www.readbyqxmd.com/read/24310984/methylomics-analysis-identifies-epigenetically-silenced-genes-and-implies-an-activation-of-%C3%AE-catenin-signaling-in-cervical-cancer
#11
Yu-Chih Chen, Rui-Lan Huang, Yung-Kai Huang, Yu-Ping Liao, Po-Hsuan Su, Hui-Chen Wang, Cheng-Chang Chang, Ya-Wen Lin, Mu-Hsien Yu, Tang-Yuan Chu, Hung-Cheng Lai
Using DNA methylation biomarkers in cancer detection is a potential direction in clinical testing. Some methylated genes have been proposed for cervical cancer detection; however, more reliable methylation markers are needed. To identify new hypermethylated genes in the discovery phase, we compared the methylome between a pool of DNA from normal cervical epithelium (n = 19) and a pool of DNA from cervical cancer tissues (n = 38) using a methylation bead array. We integrated the differentially methylated genes with public gene expression databases, which resulted in 91 candidate genes...
July 1, 2014: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/24260446/targeting-of-histone-deacetylases-to-reactivate-tumour-suppressor-genes-and-its-therapeutic-potential-in-a-human-cervical-cancer-xenograft-model
#12
Dingqing Feng, Jiao Wu, Yuan Tian, Hu Zhou, Ying Zhou, Weiping Hu, Weidong Zhao, Haiming Wei, Bin Ling, Chunhong Ma
Aberrant histone acetylation plays an essential role in the neoplastic process via the epigenetic silencing of tumour suppressor genes (TSGs); therefore, the inhibition of histone deacetylases (HDAC) has become a promising target in cancer therapeutics. To investigate the correlation of histone acetylation with clinicopathological features and TSG expression, we examined the expression of acetylated H3 (AcH3), RARβ2, E-cadherin, and β-catenin by immunohistochemistry in 65 cervical squamous cell carcinoma patients...
2013: PloS One
https://www.readbyqxmd.com/read/24244294/the-role-of-nuclear-%C3%AE-catenin-accumulation-in-the-twist2-induced-ovarian-cancer-emt
#13
Yubin Mao, Jinfei Xu, Zhihan Li, Nini Zhang, Hao Yin, Zuguo Liu
BACKGROUND: Twist2 has been shown to promote human tumor invasion as in breast cancer and cervical cancer. However, whether Twist2 promotes human ovarian cancer progression remains to be elucidated. Here, we investigate the role of Twist2 in ovarian cancer invasion and metastasis as well as the underlying molecular mechanisms. METHODS: Twist2 expression was detected by Immunohistochemistry (IHC) on tissue microarray of human ovarian cancers with scoring procedure according to the staining intensity and pattern...
2013: PloS One
https://www.readbyqxmd.com/read/24030860/through-the-glass-darkly-intraepithelial-neoplasia-top-down-differentiation-and-the-road-to-ovarian-cancer
#14
REVIEW
Christopher P Crum, Michael Herfs, Gang Ning, Jonathan G Bijron, Brooke E Howitt, Cynthia A Jimenez, Suchanan Hanamornroongruang, Frank D McKeon, Wa Xian
It is currently hoped that deaths from extra-uterine high-grade serous cancer (HGSC) will be reduced via opportunistic salpingectomy in healthy women. Accumulated data implicate the fimbria as a site of origin and descriptive molecular pathology and experimental evidence strongly support a serous carcinogenic sequence in the Fallopian tube. Both direct and indirect ('surrogate') precursors suggest that the benign tube undergoes important biological changes after menopause, acquiring abnormalities in gene expression that are often shared with malignancy, including PAX2, ALDH1, LEF1, RCN1, RUNX2, beta-catenin, EZH2, and others...
December 2013: Journal of Pathology
https://www.readbyqxmd.com/read/24020724/high-risk-human-papillomavirus-load-and-biomarkers-in-cervical-intraepithelial-neoplasia-and-cancer
#15
Mee Soo Chang, Sohee Oh, Eun-Jung Jung, Jeong Hwan Park, Hye-Won Jeon, Taek Sang Lee, Jung Ho Kim, Euno Choi, Sun-Ju Byeon, In-Ae Park
The purpose of this study was to examine the implication of high-risk human papillomavirus (HPV) load in cervical intraepithelial neoplasia (CIN) and cancer, and to detect biomarkers in cervical disease. We conducted high-risk HPV DNA load and cervical cytology tests in 343 women, cervical tissue biopsy in 143 women, and immunohistochemistry for p16(INK4A), cyclin D1, p53, cyclooxygenase-2, Ki-67, GLUT1, hPygopus2, and beta-catenin. As a result, HPV load [relative light units (RLU) value] was correlated with the histological severity of cervical disease (p < 0...
May 2014: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/23301094/ampk-activators-suppress-cervical-cancer-cell-growth-through-inhibition-of-dvl3-mediated-wnt-%C3%AE-catenin-signaling-activity
#16
H T Kwan, David W Chan, Patty C H Cai, Celia S L Mak, Mingo M H Yung, Thomas H Y Leung, Oscar G W Wong, Annie N Y Cheung, Hextan Y S Ngan
Recent evidence has suggested that AMPK activators may be applied as therapeutic drugs in suppressing cancer cell growth. However, the molecular mechanism of their suppressive function in cancer cells is still unclear. Here we show that AMPK activators impair cervical cancer cell growth through the reduction of DVL3, a positive regulator in Wnt/β-catenin signaling and an oncogenic player in cervical cancer tumorigenesis. By western blot and immunohistochemical analyses, we demonstrated that DVL3 was frequently upregulated and significantly associated with elevated β-catenin (P = 0...
2013: PloS One
https://www.readbyqxmd.com/read/23226522/phytochemicals-attenuating-aberrant-activation-of-%C3%AE-catenin-in-cancer-cells
#17
Dan Wang, Mitchell L Wise, Feng Li, Moul Dey
Phytochemicals are a rich source of chemoprevention agents but their effects on modulating the Wnt/β-catenin signaling pathway have remained largely uninvestigated. Aberrantly activated Wnt signaling can result in the abnormal stabilization of β-catenin, a key causative step in a broad spectrum of cancers. Here we report the modulation of lithium chloride-activated canonical Wnt/β-catenin signaling by phytochemicals that have antioxidant, anti-inflammatory or chemopreventive properties. The compounds were first screened with a cervical cancer-derived stable Wnt signaling reporter HeLa cell line...
2012: PloS One
https://www.readbyqxmd.com/read/23154266/reduced-expression-of-dkk3-is-associated-with-adverse-clinical-outcomes-of-uterine-cervical-squamous-cell-carcinoma
#18
Seok-Woo Ryu, Jae Hyung Kim, Mi Kyung Kim, Youn-Jeong Lee, Jun-Soo Park, Hyoung-Moo Park, Dong-Ho Kim, Sang-Hoon Lee, Eun-Ju Lee
OBJECTIVE: The aim of this study was to assess the expression of DKK3 protein and its target, beta-catenin, in uterine cervical squamous cell carcinoma and to determine potential clinical correlations. MATERIALS AND METHODS: Six carcinoma in-situ (CIS) tissues and 88 invasive cervical cancer tissues were included in the study. Twenty-two normal cervical tissues and one gastric cancer tissue were used as controls. The expression of DKK3 and beta-catenin proteins was evaluated by immunohistochemical analysis...
January 2013: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/23097631/tight-junction-proteins-claudin-3-and-claudin-4-control-tumor-growth-and-metastases
#19
Xiying Shang, Xinjian Lin, Edwin Alvarez, Gerald Manorek, Stephen B Howell
The extent of tight junction (TJ) formation is one of many factors that regulate motility, invasion, and metastasis. Claudins are required for the formation and maintenance of TJs. Claudin-3 (CLDN3) and claudin-4 (CLDN4) are highly expressed in the majority of ovarian cancers. We report here that CLDN3 and CLDN4 each serve to constrain the growth of human 2008 cancer xenografts and limit metastatic potential. Knockdown of CLDN3 increased in vivo growth rate by 2.3-fold and knockdown of CLDN4 by 3.7-fold in the absence of significant change in in vitro growth rate...
October 2012: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/23067217/altered-expression-of-ezrin-e-cadherin-and-%C3%AE-catenin-in-cervical-neoplasia
#20
COMPARATIVE STUDY
E Auvinen, O Carpen, T Korpela, M Ronty, A Vaheri, J Tarkkanen
High-grade cervical squamous intraepithelial lesions (CIN) as well as squamous cell carcinoma and adenocarcinoma of the cervix are associated with persistent high-risk human papillomavirus (HPV) infection. A number of cellular events play a role in HPV pathogenesis and in the development of cervical lesions, including alterations in cell adhesion and motility. The crucial plasma membrane - cytoskeleton linker protein ezrin of the Ezrin-Radixin-Moesin (ERM) protein family is involved in the regulation of cell morphology, cell adhesion and invasion...
2013: Neoplasma
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