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https://www.readbyqxmd.com/read/28927249/gut-microbiota-obesity-and-metabolic-disorders
#1
Alessandro Federico, Marcello Dallio, Rosa DI Sarno, Valentina Giorgio, Luca Miele
Obesity, diabetes and metabolic disorders represent hugely significant problems concerning the health in Western countries and the study of gut microbiota in metabolic pathologies is part of this framework. Diet effects on intestinal microbial composition and its role in pathogenetic mechanisms responsible for both obesity and systemic, hepatic and adipose tissue inflammation, represent at the moment one of this mostpromising topic in gastroenterology research. Gut health safety is essential, but it needs to be further explored in order to understand and interrupt the pathogenetic mechanisms, which support a large number of diseases...
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28927218/endoscopic-assisted-median-aperture-approach-for-resection-of-fourth-ventricular-tumor-and-confirmation-of-patency-of-cerebral-aqueduct-using-an-adjustable-angle-endoscope-technical-case-report
#2
Ryan Austerman, Joshua Lucas, Alexandra Kammen, Gabriel Zada
BACKGROUND AND IMPORTANCE: Open microsurgical approaches to the roof of the fourth ventricle via a telovelar approach typically require cerebellar retraction and/or splitting of the vermis and may be associated with postoperative neurological morbidities. In this case report and technical note, we describe the use of an adjustable-angle endoscope inserted into the median aperture via suboccipital craniotomy, resulting in enhanced visualization of the roof of the fourth ventricle and cerebral aqueduct and maximal safe tumor resection...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28927057/effect-of-epithelial-growth-factor-on-matrix-metalloproteinase-2-and-e-cadherin-%C3%AE-catenin-expression-in-an-in-situ-model-of-tumorigenesis
#3
Natalia Festugatto Navarini, Vera Cavalcanti De Araújo, Marcelo Sperandio, Marcelo Henrique Napimoga, Lucas Novaes Teixeira, Ney Soares De Araújo, Elizabeth Ferreira Martinez
The aim of the present study was to analyze the in vitro effect of various doses of epidermal growth factor (EGF; 5 and 10 ng/ml) on matrix metalloproteinase-2 (MMP-2) secretion and E-cadherin/β-catenin expression by co-cultured cells that mimic an in situ carcinoma ex-pleomorphic adenoma, where benign myoepithelial cells from a pleomorphic adenoma surround malignant epithelial cells. EGF was supplemented in various doses and the effects were evaluated following four days of cell culture. ELISA was performed to determine MMP-2 secretion levels...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926802/patterns-of-trunk-muscle-activation-during-walking-and-pole-walking-using-statistical-non-parametric-mapping
#4
Luca Zoffoli, Massimiliano Ditroilo, Ario Federici, Francesco Lucertini
This study used surface electromyography (EMG) to investigate the regions and patterns of activity of the external oblique (EO), erector spinae longissimus (ES), multifidus (MU) and rectus abdominis (RA) muscles during walking (W) and pole walking (PW) performed at different speeds and grades. Eighteen healthy adults undertook W and PW on a motorized treadmill at 60% and 100% of their walk-to-run preferred transition speed at 0% and 7% treadmill grade. The Teager-Kaiser energy operator was employed to improve the muscle activity detection and statistical non-parametric mapping based on paired t-tests was used to highlight statistical differences in the EMG patterns corresponding to different trials...
September 9, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28926706/structural-and-kinetic-characterization-of-the-intrinsically-disordered-protein-sev-ntail-through-enhanced-sampling-simulations
#5
Mattia Bernetti, Matteo Masetti, Fabio Pietrucci, Martin Blackledge, Malene Ringkjøbing Jensen, Maurizio Recanatini, Luca Mollica, Andrea Cavalli
Intrinsically disordered proteins (IDPs) are emerging as an important class of the proteome. Being able to interact with different molecular targets, they participate in many physiological and pathological activities. However, due to their intrinsically heterogeneous nature, determining the equilibrium properties of IDPs is still a challenge for biophysics. Herein, we applied state-of-the-art enhanced sampling methods to Sev NTAIL, a test case of IDPs, and constructed a bin-based kinetic model to unveil the underlying kinetics...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926683/salvage-rates-and-prognostic-factors-after-relapse-in-children-and-adolescents-with-malignant-peripheral-nerve-sheath-tumors
#6
Luca Bergamaschi, Gianni Bisogno, Carla Manzitti, Paolo D'Angelo, Giuseppe Maria Milano, Angela Scagnellato, Mirko Cappelletti, Stefano Chiaravalli, Patrizia Dall'Igna, Rita Alaggio, Antonio Ruggiero, Martina Di Martino, Maria Carmen Affinita, Marta Pierobon, Alberto Garaventa, Michela Casanova, Andrea Ferrari
BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it is generally characterized by poor outcome, particularly for relapsing patients. MATERIALS AND METHODS: This study considered 73 patients <21 years of age with relapsing MPNST observed among 120 patients enrolled in Italian pediatric protocols from 1979 to 2004. With the aim of possibly establishing a risk-adapted stratification, patients' outcome was examined using univariate and multivariate analysis based on clinical features at onset, first-line treatments, clinical findings at the time of first relapse, and second-line treatments...
September 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28926392/flexible-adult-acquired-flatfoot-deformity-comparison-between-weight-bearing-and-non-weight-bearing-measurements-using-cone-beam-computed-tomography
#7
Cesar de Cesar Netto, Lew C Schon, Gaurav K Thawait, Lucas Furtado da Fonseca, Apisan Chinanuvathana, Wojciech B Zbijewski, Jeffrey H Siewerdsen, Shadpour Demehri
BACKGROUND: The 3-dimensional nature of adult acquired flatfoot deformity can be challenging to characterize using radiographs. We tested the hypothesis that measurements on weight-bearing (WB) cone-beam computed tomography (CT) images were more useful for demonstrating the severity of the deformity than non-weight-bearing (NWB) measurements. METHODS: We prospectively enrolled 12 men and 8 women (mean age, 52 years; range, 20 to 88 years) with flexible adult acquired flatfoot deformity...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28926124/reliability-of-urinary-cytology-and-cystoscopy-for-the-screening-and-diagnosis-of-bladder-cancer-in-patients-with-neurogenic-bladder-a-systematic-review
#8
REVIEW
Quentin Alimi, Juliette Hascoet, Andrea Manunta, Solène-Florence Kammerer-Jacquet, Grégory Verhoest, Charlène Brochard, Lucas Freton, Jacques Kerdraon, Nelly Senal, Laurent Siproudhis, Nathalie Rioux-Leclercq, Benjamin Brucker, Xavier Gamé, Benoit Peyronnet
AIMS: To assess the reliability of urinary cytology and cystoscopy to screen and diagnose bladder cancer in patients with NB. PATIENTS AND METHODS: A systematic literature search of the Medline and Embase databases was performed in April 2017. Data extraction was performed by two independent reviewers. A narrative synthesis was made. RESULTS: Out of 220 records assessed, 15 were included in this systematic review. All studies were prospective or retrospective series with no control group...
September 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28926077/low-temperature-growth-of-fully-covered-single-layer-graphene-using-a-cocu-catalyst
#9
Hisashi Sugime, Lorenzo D'Arsié, Santiago Esconjauregui, Guofang Zhong, Xingyi Wu, Eugen Hildebrandt, Hikmet Sezen, Matteo Amati, Luca Gregoratti, Robert S Weatherup, John Robertson
A bimetallic CoCu alloy thin-film catalyst is developed that enables the growth of uniform, high-quality graphene at 750 °C in 3 min by chemical vapour deposition. The growth outcome is found to vary significantly as the Cu concentration is varied, with ∼1 at% Cu added to Co yielding complete coverage single-layer graphene growth for the conditions used. The suppression of multilayer formation is attributable to Cu decoration of high reactivity sites on the Co surface which otherwise serve as preferential nucleation sites for multilayer graphene...
September 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28926048/a-new-pu-iii-coordination-geometry-in-c5h5nbr-2-pucl3-h2o-5-%C3%A2-2cl%C3%A2-2h2o-as-obtained-via-supramolecular-assembly-in-aqueous-high-chloride-media
#10
Robert G Surbella, Lucas C Ducati, Kristi L Pellegrini, Bruce K McNamara, Jochen Autschbach, Jon M Schwantes, Christopher L Cahill
Crystals of a hydrated Pu(iii) chloride, (C5H5NBr)2[PuCl3(H2O)5]·2Cl·2H2O, were grown via slow evaporation from acidic aqueous, high chloride media. X-ray diffraction data reveals the neutral [PuCl3(H2O)5] tecton is assembled via charge assisted hydrogen and halogen bonds donated by 4-bromopyridinium cations and a series of inter-tecton hydrogen bonds.
September 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28925907/atrial-fibrillation-ablation-increases-inflammation-chemokine-modulation-suppresses-activation-of-leukocytes-isolated-after-ablation
#11
Alexandra Lucas, Mohammad Al-Ani, Sriram Ambadapadi, Jordan R Yaron, Donghang Zheng, Adisson Fortunel, Maia Doroton-Guevara, Liying Liu, Sufi Morshed, Jay Fricker, William Miles, Matthew McKillop
AIMS: Atrial fibrillation (AF) ablation is associated with increased circulating markers of inflammation. Innate immune, or inflammation, pathways up-regulate mononuclear cell responses and may increase risk for recurrent arrhythmia. Chemokines and serine protease coagulation pathways both activate innate immune responses. Here, we measured inflammatory markers in peripheral blood samples from patients after cryoballoon and/or radiofrequency pulmonary vein isolation and assessed the capacity for inhibition of chemokine and serine protease pathways to block cell activation...
September 18, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28925732/interleukin-10-gene-transfer-in-rat-limbal-transplantation
#12
Claude Kaufmann, Lauren A Mortimer, Helen M Brereton, Yazad D Irani, Douglas Ga Parker, Donald S Anson, Lucas M Bachmann, Keryn A Williams
PURPOSE: To evaluate the gene transfer of the interleukin (IL)-10 cytokine as a treatment modality for prolonging limbal allograft survival in a rat model. MATERIALS AND METHODS: Adenoviral (AV) and lentiviral (LV) vectors were produced for ex vivo gene transfer into limbal graft tissue prior to orthotopic transplantation. Experimental groups comprised unmodified isografts, unmodified allografts, allografts transfected with a reporter gene, and allografts transfected with IL-10...
September 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28925725/light-sensitive-drugs-in-topical-formulations-stability-indicating-methods-and-photostabilization-strategies
#13
Giuseppina Ioele, Lorena Tavano, Michele De Luca, Rita Muzzalupo, Annalisa Mancuso, Gaetano Ragno
Photostability tests applied on commercial specialties for topical use have demonstrated a greater vulnerability of several drugs, due to greater exposure to light than other pharmaceutical forms. Photodegradation of a drug can considerably modify its pharmacokinetic behavior by varying the therapeutic index. The evaluation of the degradation profile of a drug, according to the ICH rules, is of primary importance in developing an appropriate topical formulation. Advanced strategies have been proposed to increase the protection from the light of the photolabile drugs...
September 19, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28925604/epidemiology-and-prognosis-of-congenital-diaphragmatic-hernia-a-population-based-cohort-study-in-utah
#14
Hari Shanmugam, Luca Brunelli, Lorenzo D Botto, Sergey Krikov, Marcia L Feldkamp
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a relatively frequent and severe malformation. Population-based data on clinical presentation and associated mortality are scarce. We examined a state-wide cohort of infants with a clinically validated diagnosis of CDH to assess their clinical profile, sociodemographic patterns, and infant mortality. METHODS: We identified CDH cases from Utah's statewide population-based surveillance program among the cohort of all pregnancy outcomes (live births, stillbirths, and pregnancy terminations) delivered from 1999 to 2011...
September 19, 2017: Birth defects research
https://www.readbyqxmd.com/read/28925575/evaluation-of-neonatal-transport-in-a-european-country-shows-that-regional-provision-is-not-cost-effective-or-sustainable-and-needs-to-be-re-organised
#15
Carlo Bellini, Michela Pasquarella, Luca A Ramenghi, Daniela Ambrosino, Anna F Sciomachen
AIM: There are three dedicated and 41 on-call neonatal emergency transport services (NETS) in Italy and activity levels vary dramatically. We examined the cost-effectiveness of a hub-and-spoke NETS by looking at the costs and activity levels in the Liguria region and established the financial needs for improving NETS across Italy. METHODS: The cost of running NETS in the Liguria region from 2012-2015 was evaluated and analysed and three different models determined the transports needed each year to provide the best organisational model...
September 19, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28924967/postoperative-radiotherapy-for-prostate-cancer-the-sooner-the-better-and-potential-to-reduce-toxicity-even-further
#16
Paolo Borghetti, Luigi Spiazzi, Claudia Cozzaglio, Sara Pedretti, Bruno Caraffini, Luca Triggiani, Diana Greco, Lilia Bardoscia, Fernando Barbera, Michela Buglione, Stefano Maria Magrini
PURPOSE: To evaluate biochemical relapse-free survival (bRFS), overall survival (OS), late rectal and bladder toxicities in a retrospective single institution series, also applying an in-house software for biological dose calculation. METHODS: 258 patients submitted to radiotherapy after prostatectomy were considered. Differences between groups were calculated using the log-rank test and the relevant clinical and therapeutic variables were considered for multivariate analysis...
September 18, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28924249/validating-a-therapy-oriented-complication-grading-system-in-lumbar-spine-surgery-a-prospective-population-based-study
#17
David Bellut, Jan-Karl Burkhardt, Dania Schultze, Howard J Ginsberg, Luca Regli, Johannes Sarnthein
The aim of the present study was to validate a therapy-oriented complication grading system in a well-defined neurosurgical patient population in which complications may entrain neurological deficits, which are severe but not treated. The prospective patient registry of the Department of Neurosurgery, University of Zurich provides extensive population-based data. In this study we focused on complications after lumbar spine surgeries and rated their severity by Clavien-Dindo grade (CDG). Analyzing 138 consecutive surgeries we noted 44 complications...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923954/macroevolutionary-shifts-of-wnta-function-potentiate-butterfly-wing-pattern-diversity
#18
Anyi Mazo-Vargas, Carolina Concha, Luca Livraghi, Darli Massardo, Richard W R Wallbank, Linlin Zhang, Joseph D Papador, Daniel Martinez-Najera, Chris D Jiggins, Marcus R Kronforst, Casper J Breuker, Robert D Reed, Nipam H Patel, W Owen McMillan, Arnaud Martin
Butterfly wing patterns provide a rich comparative framework to study how morphological complexity develops and evolves. Here we used CRISPR/Cas9 somatic mutagenesis to test a patterning role for WntA, a signaling ligand gene previously identified as a hotspot of shape-tuning alleles involved in wing mimicry. We show that WntA loss-of-function causes multiple modifications of pattern elements in seven nymphalid butterfly species. In three butterflies with a conserved wing-pattern arrangement, WntA is necessary for the induction of stripe-like patterns known as symmetry systems and acquired a novel eyespot activator role specific to Vanessa forewings...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923860/in-silico-modeling-of-immunotherapy-and-stroma-targeting-therapies-in-human-colorectal-cancer
#19
Jakob Nikolas Kather, Jan Poleszczuk, Meggy Suarez-Carmona, Johannes Krisam, Pornpimol Charoentong, Nektarios A Valous, Cleo-Aron Weis, Luca Tavernar, Florian Leiss, Esther Herpel, Fee Klupp, Alexis Ulrich, Martin Schneider, Alexander Marx, Dirk Jaeger, Niels Halama
Despite the fact that the local immunological microenvironment shapes the prognosis of colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal cancer patients. A better understanding of the complex immunological interplay within the microenvironment is required. In this study, we utilized wet lab migration experiments and quantitative histological data of human colorectal cancer tissue samples (n=20) including tumor cells, lymphocytes, stroma and necrosis to generate a multi-agent spatial model...
September 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28923578/coastal-dynamics-vs-beach-users-attitudes-and-perceptions-to-enhance-environmental-conservation-and-management-effectiveness
#20
Roberta Aretano, Luca Parlagreco, Teodoro Semeraro, Giovanni Zurlini, Irene Petrosillo
This work carries out a landscape analysis for the last 60years to compare the degree of preservation of two areas on the same Italian coastline characterized by different environmental protection levels: a National designated protected areas and a highly tourist coastal destination. The conversion of natural land-covers into human land uses were detected for protected and unprotected coastal stretches highlighting that the only establishment of a protected area is not enough to stem undesirable land-use outcomes...
September 15, 2017: Marine Pollution Bulletin
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