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https://www.readbyqxmd.com/read/29334456/building-ion-conduction-highways-in-polymeric-electrolytes-by-manipulating-protein-configuration
#1
Xuewei Fu, Chunhui Li, Yu Wang, Lucas Paul Kovatch, Louis Scudiero, Jin Liu, Wei-Hong Zhong
Solid polymer electrolytes play a critical role in the development of safe, flexible and all-solid-state energy storage devices. However, the low ion-conductivity has been the primary challenge impeding them from practical applications. Here, we propose a new biotechnology to fabricate novel protein-ceramic hybrid nanofillers for simultaneously boosting the ionic conductivity, mechanical properties and even adhesion properties of solid polymer electrolytes. This hybrid nanofiller is fabricated by coating ion-conductive soy-proteins onto TiO2 nanoparticles via a controlled denaturation process in appropriate solvent and conditions...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29334364/compactness-of-viral-genomes-effect-of-disperse-and-localized-random-mutations
#2
Anže Lošdorfer Božič, Cristian Micheletti, Rudolf Podgornik, Luca Tubiana
Genomes of single-stranded RNA viruses have evolved to optimize several concurrent properties. One of them is the architecture of their genomic folds, which must not only feature precise structural elements at specific positions, but also allow for overall spatial compactness. The latter was shown to be disrupted by random synonymous mutations, a disruption which can consequently negatively affect genome encapsidation. In this study, we use three mutation schemes with different degrees of locality to mutate the genomes of phage MS2 and Brome Mosaic Virus in order to understand the observed sensitivity of the global compactness of their folds...
January 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29334362/investigation-of-resistance-switching-in-siox-rram-cells-using-a-3d-multi-scale-kinetic-monte-carlo-simulator
#3
Toufik Sadi, Adnan Mehonic, Luca Montesi, Mark Buckwell, Anthony Kenyon, Asen Asenov
We employ an advanced three-dimensional (3D) electro-thermal simulator to explore the physics and potential of oxide-based resistive random-access memory (RRAM) cells. The physical simulation model has been developed recently, and couples a kinetic Monte Carlo study of electron and ionic transport to the self-heating phenomenon while accounting carefully for the physics of vacancy generation and recombination, and trapping mechanisms. The simulation framework successfully captures resistance switching, including the electroforming, set and reset processes, by modeling the dynamics of conductive filaments in the 3D space...
January 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29333882/vaginoplasty-what-s-new-from-1946-to-date-commentary-on-vaginoplasty-with-acellular-dermal-matrix-after-radical-resection-for-carcinoma-of-the-uterine-cervix
#4
Roberto Cuomo, Luca Grimaldi, Cesare Brandi, Andrea Sisti, Giuseppe Nisi
No abstract text is available yet for this article.
January 15, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29333269/the-immune-system-of-the-liver-50-years-of-strangeness
#5
EDITORIAL
Michaela Lucas, Axel Kallies, Paul Klenerman
No abstract text is available yet for this article.
December 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29332999/an-integrated-electrolysis-electrospray-ionization-antimicrobial-platform-using-engineered-water-nanostructures-ewns-for-food-safety-applications
#6
Nachiket Vaze, Yi Jiang, Lucas Mena, Yipei Zhang, Dhimiter Bello, Stephen S Leonard, Anna M Morris, Mary Eleftheriadou, Georgios Pyrgiotakis, Philip Demokritou
Engineered water nanostructures (EWNS) synthesized utilizing electrospray and ionization of water, have been, recently, shown to be an effective, green, antimicrobial platform for surface and air disinfection, where reactive oxygen species (ROS), generated and encapsulated within the particles during synthesis, were found to be the main inactivation mechanism. Herein, the antimicrobial potency of the EWNS was further enhanced by integrating electrolysis, electrospray and ionization of de-ionized water in the EWNS synthesis process...
March 2018: Food Control
https://www.readbyqxmd.com/read/29332782/long-distance-nonstop-neonatal-transport-from-shanghai-china-to-genoa-italy
#7
Carlo Bellini, Simona Serveli, Luigi A, Pietro M, Daniele S, Luca A Ramenghi, Tiziana Cinti, Francesco Campone
The purpose of this article is to describe the long-distance, nonstop intercontinental transport of a severely ill, mechanically ventilated newborn from Shanghai, China, to Genoa, Italy focusing in particular on the clinical and planning difficulties. The aircraft equipment, the assessment and preparation for transport are discussed.
January 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29332741/abdominal-and-pelvic-floor-electromyographic-analysis-during-abdominal-hypopressive-gymnastics
#8
Lucas Ithamar, Alberto Galvão de Moura Filho, Marco Aurélio Benedetti Rodrigues, Kelly Cristina Duque Cortez, Vinícius Gomes Machado, Claudia Regina Oliveira de Paiva Lima, Eduarda Moretti, Andrea Lemos
INTRODUCTION: Abdominal hypopressive gymnastics appeared as an alternative to traditional abdominal exercises to promote abdominal muscles strength without overloading the pelvic floor muscles (PFM). To determine the activation level of abdominal muscles and PFM and the posture influence in the level of activation in these muscles during abdominal hypopressive gymnastics, we used surface electromyography in young and healthy multipara women. METHODS: This is an observational study with eutrophic nulliparous women aged between 18 and 35 years, with abdominal skinfold less than or equal to 3 cm and active or irregularly active physical activity...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332640/cognitive-impairment-in-patients-with-psoriasis-a-matched-case-control-study
#9
Marco Innamorati, Rossella M Quinto, David Lester, Luca Iani, Dario Graceffa, Claudio Bonifati
BACKGROUND: In the past decade, a few studies have suggested that psoriasis could be associated with the presence of mild cognitive deficits. OBJECTIVES: The aim of the present matched case-control study was to investigate several cognitive domains (executive functions, verbal memory, attention, and language) in a sample of outpatients with psoriasis. We also investigated whether cognitive impairment was associated with poor health-related quality of life (HRQoL) in patients with psoriasis...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29332554/evaluating-the-dose-dependent-mechanism-of-action-of-trazodone-by-estimation-of-occupancies-for-different-brain-neurotransmitter-targets
#10
Luca Settimo, David Taylor
Trazodone is a drug that was introduced in the clinic almost 40 years ago. It is licensed to treat depression, but it is also commonly used off-label to treat insomnia. A recent study shows that it could be promising in preventing neurodegeneration in mice, and clinical trials to assess its possible beneficial effects on dementia and Alzheimer's disease are expected to start soon in humans. In this study, we describe the dose-dependent pharmacology of trazodone by carrying out pharmacokinetic simulations aiming to predict the brain concentrations of trazodone for different drug-dosing regimens and calculating occupancy for 28 different targets for which published trazodone-binding data are available...
January 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29332378/role-of-psoriasis-on-subclinical-cardiovascular-disease
#11
Luca DI Vito, Damiano Abeni, Claudia Uras, Alessandra Magenta, Roberta Ciarapica, Maurizio C Capogrossi, Guido Melillo
No abstract text is available yet for this article.
January 11, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29332375/recurrent-aphtous-stomatitis
#12
Luca Giannetti, Alberto Murri Dello Diago, Lorenzo Lo Muzio
Recurrent aphtous stomatitis (RAS; recurrent aphtous ulcers, canker sores) is the most common ulcerative disease of the oral mucosa. In this paper we presented the main clinical features, epidemiologic data, etiopathogenetic factors and clinical management, based on the current medical literature reports.
January 11, 2018: Minerva Stomatologica
https://www.readbyqxmd.com/read/29332254/comparison-of-adjustable-continence-therapy-periurethral-balloons-and-artificial-urinary-sphincter-in-female-patients-with-stress-urinary-incontinence-due-to-intrinsic-sphincter-deficiency
#13
Lucas Freton, Lauranne Tondut, Isabelle Enderle, Juliette Hascoet, Andrea Manunta, Benoit Peyronnet
INTRODUCTION AND HYPOTHESIS: The objective was to compare the outcomes of the ACT® device with those of the artificial urinary sphincter (AUS) AMS 800 in the treatment of stress urinary incontinence (SUI) due to sphincter deficiency in women. METHODS: All the women who underwent surgical treatment for SUI due to intrinsic sphincter deficiency from 2007 to 2017 were included in a single-center retrospective study. The primary endpoint was the functional outcome...
January 13, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29332231/stage-specific-therapeutic-strategies-of-medication-related-osteonecrosis-of-the-jaws-a-systematic-review-and-meta-analysis-of-the-drug-suspension-protocol
#14
REVIEW
Luca Ramaglia, Agostino Guida, Vincenzo Iorio-Siciliano, Alessandro Cuozzo, Andrea Blasi, Anton Sculean
OBJECTIVE: The most debated topic about medication-related osteonecrosis of the jaws (MRONJ) is its therapy, as there are no definitive guidelines. The aims of this systematic review were (a) to outline the best therapeutic approach according to the stage at diagnosis and (b) to perform a meta-analysis to assess whether the drug-holiday protocol may be or not an effective method in the management of MRONJ patients. MATERIALS AND METHODS: The systematic review was performed following the PRISMA principles...
January 13, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29332043/serum-non-ceruloplasmin-non-albumin-copper-elevation-in-mild-cognitive-impairment-and-dementia-due-to-alzheimer-s-disease-a-case-control-study
#15
Luca Rozzini, Francesco Lanfranchi, Andrea Pilotto, Simona Catalani, Maria Enrica Gilberti, Matteo Paganelli, Pietro Apostoli, Alessandro Padovani
Several studies showed high serum copper levels in Alzheimer's disease (AD). The present study applied a newly developed method to detect serum copper free from proteins (free-Cu). Forty-four patients affected by dementia due to AD, thirty-six patients affected by mild cognitive impairment (MCI) due to AD, and twenty-eight healthy controls underwent clinical, cognitive, and MRI assessment. The new method showed higher free-Cu concentrations in MCI and dementia due to AD compared to controls (p < 0.0001)...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331979/now-you-see-me-a-pragmatic-cohort-study-comparing-first-and-final-radiological-diagnoses-in-the-emergency-department
#16
Björn Mattsson, David Ertman, Aristomenis Konstantinos Exadaktylos, Luca Martinolli, Wolf E Hautz
OBJECTIVES: To (1) compare timely but preliminary and definitive but delayed radiological reports in a large urban level 1 trauma centre, (2) assess the clinical significance of their differences and (3) identify clinical predictors of such differences. DESIGN, SETTING AND PARTICIPANTS: We performed a retrospective record review for all 2914 patients who presented to our university affiliated emergency department (ED) during a 6-week period. In those that underwent radiological imaging, we compared the patients' discharge letter from the ED to the definitive radiological report...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331564/direct-renin-inhibition-is-not-enough-to-prevent-reactive-oxygen-species-generation-and-vascular-dysfunction-in-renovascular-hypertension
#17
Alisson Martins-Oliveira, Danielle A Guimaraes, Carla S Ceron, Elen Rizzi, Diogo M M Oliveira, Carlos R Tirapelli, Dulce E Casarini, Fernanda B Fernandes, Lucas C Pinheiro, Jose E Tanus-Santos
Renin-angiotensin system activation promotes oxidative stress and endothelial dysfunction. However, no previous study has examined the effects of the renin inhibitior aliskiren, either alone or combined with angiotensin II type 1 antagonists on alterations induced by two-kidney, one-clip (2K1C) hypertension. We compared the vascular effects of aliskiren (50mg/kg/day), losartan (10mg/kg/day), or both by gavage for 4 weeks in 2K1C and control rats. Treatment with losartan, aliskiren, or both exerted similar antihypertensive effects...
January 10, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29331243/tolerance-and-potential-for-adaptation-of-a-baltic-sea-rockweed-under-predicted-climate-change-conditions
#18
Luca Rugiu, Iita Manninen, Eva Rothäusler, Veijo Jormalainen
Climate change is threating species' persistence worldwide. To predict species responses to climate change we need information not just on their environmental tolerance but also on its adaptive potential. We tested how the foundation species of rocky littoral habitats, Fucus vesiculosus, responds to combined hyposalinity and warming projected to the Baltic Sea by 2070-2099. We quantified responses of replicated populations originating from the entrance, central, and marginal Baltic regions. Using replicated individuals, we tested for the presence of within-population tolerance variation...
December 18, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29331082/mechanistic-target-of-rapamycin-complex-1-and-2-in-human-temporal-lobe-epilepsy
#19
Delia M Talos, Leah M Jacobs, Sarah Gourmaud, Carlos A Coto, Hongyu Sun, Kuei-Cheng Lim, Timothy H Lucas, Kathryn A Davis, Maria Martinez-Lage, Frances E Jensen
OBJECTIVE: Temporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) and Complex 2 (mTORC2) activities in the brain, as both pathways may represent unique targets for treatment. METHODS: Surgically resected hippocampal and temporal lobe samples from therapy-resistant TLE patients were analyzed by Western blotting to quantify the expression of established mTORC1 and mTORC2 activity markers and upstream or downstream signaling pathways involving the two complexes...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29330621/nonuniversal-behaviour-of-helical-two-dimensional-three-component-turbulence
#20
Moritz Linkmann, Michele Buzzicotti, Luca Biferale
The dynamics of two-dimensional three-component (2D3C) flows is relevant to describe the long-time evolution of strongly rotating flows and/or of conducting fluids with a strong mean magnetic field. We show that in the presence of a strong helical forcing, the out-of-plane component ceases to behave as a passive advected quantity and develops a nontrivial dynamics which deeply changes its large-scale properties. We show that a small-scale helicity injection correlates the input on the 2D component with the one on the out-of-plane component...
January 15, 2018: European Physical Journal. E, Soft Matter
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