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cancer detection, nanotechnology

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https://www.readbyqxmd.com/read/29458567/graphene-based-multifunctional-nanomaterials-in-cancer-detection-and-therapeutics
#1
Wenlin Gong, Zixi Hu, Ying Liang, Yiwei Wang, Rong Zheng, Juntao Tan, Zongqiang Lai, Xiaoxue Li, Jieping Li, Xiaoling Lu, Yongxiang Zhao
Nanotechnology for early diagnosis and treatment of malignant tumor is a forefront topic in the international field of biotechnology and medicine. In order to improve the effect of cancer therapy, the timely and accurate detection of the cancer is important and necessary. Graphene and its derivatives have various excellent characteristics. For example, biological sensors based on graphene are good at amplifying detection signals, and its derivatives play an important role in the early diagnosis and cancer therapy...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29434960/targeting-breast-cancer-cells-with-a-cuins2-zns-quantum-dot-labeled-ki-67-bioprobe
#2
Guang Sun, Wanying Xing, Ren Xing, Liu Cong, Sun Tong, Siyao Yu
The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive breast cancer. Ki-67 is a clinically used biomarker for breast cancer diagnosis, treatment and prognosis. Owing to the optical and chemical advantages of QDs, QD-based nanotechnology may aid the construction of a biomedical imaging platform for the study of cancer cell behavior...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29401387/ex-vivo-detection-of-circulating-tumor-cells-from-whole-blood-by-direct-nanoparticle-visualization
#3
Regivaldo G Sobral-Filho, Lindsay DeVorkin, Sarah Macpherson, Andrew Jirasek, Julian J Lum, Alexandre G Brolo
The detection of circulating tumor cells (CTCs) from blood samples can predict prognosis, response to systemic chemotherapy, and metastatic spread of carcinoma. Therefore, approaches for CTC identification is an important aspect of current cancer research. Here, a method for the direct visualization of nanoparticle-coated CTCs under dark field illumination is presented. A metastatic breast cancer cell line (4T1) was transduced with a non-native target protein (Thy1.1). Positive 4T1-Thy1.1 cells incubated with antibody-coated metallic nanoshells appeared overly bright at low magnification, allowing a quick screening of samples and easy visual detection of even single isolated CTCs...
February 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29366804/clinical-utility-of-non-epcam-based-circulating-tumor-cell-assays
#4
R Garland Austin, Tony Jun Huang, Mengxi Wu, Andrew J Armstrong, Tian Zhang
Methods enabling the isolation, detection, and characterization of circulating tumor cells (CTCs) in blood have clear potential to facilitate precision medicine approaches in patients with cancer, not only for prognostic purposes but also for prediction of the benefits of specific therapies in oncology. However, current CTC assays, which capture CTCs based on expression of epithelial cell adhesion molecule (EpCAM), fail to capture cells from de-differentiated tumors and carcinomas undergoing loss of the epithelial phenotype during the invasion/metastatic process...
January 20, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29348534/anti-cancer-activities-of-allyl-isothiocyanate-and-its-conjugated-silicon-quantum-dots
#5
Peng Liu, Mehrnaz Behray, Qi Wang, Wei Wang, Zhigang Zhou, Yimin Chao, Yongping Bao
Allyl isothiocyanate (AITC), a dietary phytochemical in some cruciferous vegetables, exhibits promising anticancer activities in many cancer models. However, previous data showed AITC to have a biphasic effect on cell viability, DNA damage and migration in human hepatoma HepG2 cells. Moreover, in a 3D co-culture of HUVEC with pericytes, it inhibited tube formation at high doses but promoted this at low doses, which confirmed its biphasic effect on angiogenesis. siRNA knockdown of Nrf2 and glutathione inhibition abolished the stimulation effect of AITC on cell migration and DNA damage...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29291161/nanotechnology-based-strategies-for-early-cancer-diagnosis-using-circulating-tumor-cells-as-a-liquid-biopsy
#6
REVIEW
Qinqin Huang, Yin Wang, Xingxiang Chen, Yimeng Wang, Zhiqiang Li, Shiming Du, Lianrong Wang, Shi Chen
Circulating tumor cells (CTCs) are cancer cells that shed from a primary tumor and circulate in the bloodstream. As a form of "tumor liquid biopsy", CTCs provide important information for the mechanistic investigation of cancer metastasis and the measurement of tumor genotype evolution during treatment and disease progression. However, the extremely low abundance of CTCs in the peripheral blood and the heterogeneity of CTCs make their isolation and characterization major technological challenges. Recently, nanotechnologies have been developed for sensitive CTC detection; such technologies will enable better cell and molecular characterization and open up a wide range of clinical applications, including early disease detection and evaluation of treatment response and disease progression...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29290827/local-intratracheal-delivery-of-perfluorocarbon-nanoparticles-to-lung-cancer-demonstrated-with-magnetic-resonance-multimodal-imaging
#7
Lina Wu, Xiaofei Wen, Xiance Wang, Chunan Wang, Xilin Sun, Kai Wang, Huiying Zhang, Todd Williams, Allen J Stacy, Junjie Chen, Anne H Schmieder, Gregory M Lanza, Baozhong Shen
Eighty percent of lung cancers originate as subtle premalignant changes in the airway mucosal epithelial layer of bronchi and alveoli, which evolve and penetrate deeper into the parenchyma. Liquid-ventilation, with perfluorocarbons (PFC) was first demonstrated in rodents in 1966 then subsequently applied as lipid-encapsulated PFC emulsions to improve pulmonary function in neonatal infants suffering with respiratory distress syndrome in 1996. Subsequently, PFC nanoparticles (NP) were extensively studied as intravenous (IV) vascular-constrained nanotechnologies for diagnostic imaging and targeted drug delivery applications...
2018: Theranostics
https://www.readbyqxmd.com/read/29247765/integration-of-biomimicry-and-nanotechnology-for-significantly-improved-detection-of-circulating-tumor-cells-ctcs
#8
Ja Hye Myung, Sin-Jung Park, Andrew Z Wang, Seungpyo Hong
Circulating tumor cells (CTCs) have received a great deal of scientific and clinical attention as a biomarker for diagnosis and prognosis of many types of cancer. Given their potential significance in clinics, a variety of detection methods, utilizing the recent advances in nanotechnology and microfluidics, have been introduced in an effort of achieving clinically significant detection of CTCs. However, effective detection and isolation of CTCs still remain a tremendous challenge due to their extreme rarity and phenotypic heterogeneity...
December 13, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29246318/size-shape-and-sequence-dependent-immunogenicity-of-rna-nanoparticles
#9
Sijin Guo, Hui Li, Mengshi Ma, Jian Fu, Yizhou Dong, Peixuan Guo
RNA molecules have emerged as promising therapeutics. Like all other drugs, the safety profile and immune response are important criteria for drug evaluation. However, the literature on RNA immunogenicity has been controversial. Here, we used the approach of RNA nanotechnology to demonstrate that the immune response of RNA nanoparticles is size, shape, and sequence dependent. RNA triangle, square, pentagon, and tetrahedron with same shape but different sizes, or same size but different shapes were used as models to investigate the immune response...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29216344/prostate-cancer-updates-on-current-strategies-for-screening-diagnosis-and-clinical-implications-of-treatment-modalities
#10
Jing-Yan Tian, Feng-Jun Guo, Guo-You Zheng, Aamir Ahmad
Prostate cancer is the most common cancer in men by way of diagnosis, and a leading cause of cancer-related deaths. Early detection and intervention remains key to its optimum clinical management. This review provides the most updated information on the recent methods of prostate cancer screening, imaging and treatment modalities. Wherever possible, clinical trial data has been supplemented to provide a comprehensive overview of current prostate cancer research and development. Considering the recent success of immunotherapy in prostate cancer, we discuss cell, DNA and viruses based, as well as combinatorial immunotherapeutic strategies in detail...
December 5, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29189149/theranostic-aspects-treatment-of-cancer-by-nanotechnology
#11
Bidisha Sarkar, Priyankar Paira
Theranostic agents or theranostic imaging as its name suggests is a combination of two terms-'diagnosis' & 'therapy'. Efforts are being made to combine both the terms into clinical formulations. This theranostic imaging is found to be very much significant to complex diseases like cancer and proliferative tumors specially now that protionic and genomic profiling can provide an accurate 'fingerprint' of each tumor, with all such kinds of informations theranostic agents can be designed in such a way that it is specific in its action and selective towards the cancer cells only, without causing any adverse effects on the normal tissue cells...
November 29, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29186662/ultrasmall-in-nano-approach-enabling-the-translation-of-metal-nanomaterials-to-clinics
#12
Domenico Cassano, Salvador PocovĂ­-MartĂ­nez, Valerio Voliani
Currently, nanomaterials are of widespread use in daily commercial products. However, the most promising and potentially impacting application is in the medical field. In particular, nano-sized noble metals hold the promise to shift the current medical paradigms for the detection and therapy of neoplasms thanks to the: i) localized surface plasmon resonances (LSPRs), ii) high electron density, and iii) suitability for straightforward development of all-in-one nano-platforms. Nonetheless, there is still no clinically approved noble metal nanomaterial for cancer therapy/diagnostic...
November 29, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29161677/nanotechnology-based-recent-approaches-for-sensing-and-remediation-of-pesticides
#13
REVIEW
Deepak Rawtani, Nitasha Khatri, Sanjiv Tyagi, Gaurav Pandey
Pesticides are meant to control and destroy the pests and weeds. They are classified into different categories on the basis their origin and type of pest they target. Chemical pesticides such as insecticides, herbicides and fungicides are commonly used in agricultural fields. However, the excessive use of these agrochemicals have adverse effects on environment such as reduced population of insect pollinators, threat to endangered species and habitat of birds. Upon consumption; chemical pesticides also cause various health issues such as skin, eye and nervous system related problems and cancer upon prolonged exposure...
November 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29149830/diagnostic-devices-for-circulating-biomarkers-detection-and-quantification
#14
Chiara Bedin, Sara Crotti, Ennio Tasciotti, Marco Agostini
Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely in centralized laboratory testing. The development of small, fast and simple to use medical device that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotechnology. To develop diagnostic devices for cancer detection, nanomaterials-based systems have significant advantages over current conventional approaches in terms of simplicity, sensitivity, specificity and rapidity...
November 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29120818/near-infrared-dye-conjugated-oxidative-stress-amplifying-polymer-micelles-for-dual-imaging-and-synergistic-anticancer-phototherapy
#15
Wonseok Yang, Joungyoun Noh, Hoyeon Park, Sian Gwon, Berwin Singh, Chulgyu Song, Dongwon Lee
The recent advances in nanotechnology have led to the development of smart nanomaterials that combine diagnostic and therapeutic functions and provide synergistic anticancer effects through the combination of different treatment modalities. Here, we report a promising theranostic nanoconstruct that can translate into multiple functionalities: fluorescence/photoacoustic imaging, acid-triggered generation of ROS (reactive oxygen species), heat and singlet oxygen production under near infrared (NIR) laser irradiation, and coupling oxidative anticancer therapy to dual imaging-guided photothermal/photodynamic therapy...
February 2018: Biomaterials
https://www.readbyqxmd.com/read/29097909/molecular-imaging-of-cancer-with-nanoparticle-based-theranostic-probes
#16
REVIEW
Ying-Yu Ma, Ke-Tao Jin, Shi-Bing Wang, Hui-Ju Wang, Xiang-Min Tong, Dong-Sheng Huang, Xiao-Zhou Mou
Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29090067/magnetic-iron-oxide-nanoparticles-as-t2-mr-imaging-contrast-agent-for-detection-of-breast-cancer-mcf-7-cell
#17
Pegah Moradi Khaniabadi, Daryoush Shahbazi-Gahrouei, Mohammad Suhaimi Jaafar, Amin Malik Shah Abdul Majid, Bita Moradi Khaniabadi, Saghar Shahbazi-Gahrouei
BACKGROUND: Advances of nanotechnology have led to the development of nano-materials with both potential diagnostic and therapeutic applications. Among them, Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) have received particular attention. Modified EDC coupling fraction was used to fabricate the SPION-C595 as an MR imaging contrast agent for breast cancer detection in early stages. METHODS: Nanoprobe characterization was confirmed using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy with Energy Dispersive X-Ray Spectroscopy (SEM-EDAX), and Photon Correlation Spectroscopy (PCS)...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29033548/the-new-era-of-nanotechnology-an-alternative-to-change-cancer-treatment
#18
REVIEW
Ancuta Jurj, Cornelia Braicu, Laura-Ancuta Pop, Ciprian Tomuleasa, Claudia Diana Gherman, Ioana Berindan-Neagoe
In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29026204/engineering-and-physical-sciences-in-oncology-challenges-and-opportunities
#19
REVIEW
Michael J Mitchell, Rakesh K Jain, Robert Langer
The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology...
November 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28966883/micrornas-in-cancer-challenges-and-opportunities-in-early-detection-disease-monitoring-and-therapeutic-agents
#20
Namita Chatterjee, Shushan Rana, Cristina Espinosa-Diez, Sudarshan Anand
PURPOSE OF REVIEW: The goals of this review are to examine the usefulness of miRNAs as diagnostic and prognostic biomarkers for cancer and to evaluate the applicability of miRNAs as cancer therapeutics. RECENT FINDINGS: Examination of miRNA milieu from body fluids offers a new alternative for quick, affordable and easy analysis of disease status in patients. Blood-based exosomal miRNAs have increased stability and are an excellent choice for clinical cancer diagnostics and prognostics...
March 2017: Current Pathobiology Reports
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