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cancer detection, nanotechnology

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https://www.readbyqxmd.com/read/28223185/nanomedicine-as-a-potent-strategy-in-melanoma-tumor-microenvironment
#1
REVIEW
Vincent Pautu, Daniela Leonetti, Elise Lepeltier, Nicolas Clere, Catherine Passirani
Melanoma originated from melanocytes is the most aggressive type of skin cancer. Despite considerable progresses in clinical treatment with the discovery of BRAF or MEK inhibitors and monoclonal antibodies, the durability of response to treatment is often limited to the development of acquired resistance and systemic toxicity. The limited success of conventional treatment highlights the importance of understanding the role of melanoma tumor microenvironment in tumor developement and drug resistance. Nanoparticles represent a promising strategy for the development of new cancer treatments able to improve the bioavailability of drugs and increase their penetration by targeting specifically tumours cells and/or tumour environment...
February 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28217434/gold-nanoparticle-based-platforms-for-circulating-cancer-marker-detection
#2
Xiaohua Huang, Ryan O'Connor, Elyahb Allie Kwizera
Detection of cancer-related circulating biomarkers in body fluids has become a cutting-edge technology that has the potential to noninvasively screen cancer, diagnose cancer at early stage, monitor tumor progression, and evaluate therapy responses. Traditional molecular and cellular detection methods are either insensitive for early cancer intervention or technically costly and complicated making them impractical for typical clinical settings. Due to their exceptional structural and functional properties that are not available from bulk materials or discrete molecules, nanotechnology is opening new horizons for low cost, rapid, highly sensitive, and highly specific detection of circulating cancer markers...
2017: Nanotheranostics (Syd)
https://www.readbyqxmd.com/read/28203204/circulating-tumor-cells-from-theory-to-nanotechnology-based-detection
#3
REVIEW
Yue Ming, Yuanyuan Li, Haiyan Xing, Minghe Luo, Ziwei Li, Jianhong Chen, Jingxin Mo, Sanjun Shi
Cancer stem cells with stem-cell properties are regarded as tumor initiating cells. Sharing stem-cell properties, circulating tumor cells (CTCs) are responsible for the development of metastasis, which significant affects CTC analysis in clinical practice. Due to their extremely low occurrence in blood, however, it is challenging to enumerate and analyze CTCs. Nanotechnology is able to address the problems of insufficient capture efficiency and low purity of CTCs owing to the unique structural and functional properties of nanomaterials, showing strong promise for CTC isolation and detection...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28157583/identification-of-high-independent-prognostic-value-of-nanotechnology-based-circulating-tumor-cell-enumeration-in-first-line-chemotherapy-for-metastatic-breast-cancer-patients
#4
Xiao-Ran Liu, Bin Shao, Jia-Xi Peng, Hui-Ping Li, Yan-Lian Yang, Wei-Yao Kong, Guo-Hong Song, Han-Fang Jiang, Xu Liang, Ying Yan
Enumeration of circulating tumor cells (CTCs) is a promising tool in the management of metastatic breast cancer (MBC). This study investigated the capturing efficiency and prognostic value of our previously reported peptide-based nanomagnetic CTC isolation system (Pep@MNPs). We counted CTCs in blood samples taken at baseline (n = 102) and later at patients' first clinical evaluation after starting firstline chemotherapy (n = 72) in a cohort of women treated for MBC. Their median follow-up was 16.3 months (range: 9...
January 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28122423/microrna-biomarkers-in-neurodegenerative-diseases-and-emerging-nano-sensors-technology
#5
REVIEW
Pratik Shah, Seok Keun Cho, Peter Waaben Thulstrup, Morten Jannik Bjerrum, Phil Hyu Lee, Ju-Hee Kang, Yong-Joo Bhang, Seong Wook Yang
MicroRNAs (miRNAs) are essential small RNA molecules (20-24 nt) that negatively regulate the expression of target genes at the post-transcriptional level. Due to their roles in a variety of biological processes, the aberrant expression profiles of miRNAs have been identified as biomarkers for many diseases, such as cancer, diabetes, cardiovascular disease and neurodegenerative diseases. In order to precisely, rapidly and economically monitor the expression of miRNAs, many cutting-edge nanotechnologies have been developed...
January 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28098821/tumor-microenvironment-modulation-via-gold-nanoparticles-targeting-malicious-exosomes-implications-for-cancer-diagnostics-and-therapy
#6
REVIEW
Catarina Roma-Rodrigues, Luís R Raposo, Rita Cabral, Fabiana Paradinha, Pedro V Baptista, Alexandra R Fernandes
Exosomes are nanovesicles formed in the endosomal pathway with an important role in paracrine and autocrine cell communication. Exosomes secreted by cancer cells, malicious exosomes, have important roles in tumor microenvironment maturation and cancer progression. The knowledge of the role of exosomes in tumorigenesis prompted a new era in cancer diagnostics and therapy, taking advantage of the use of circulating exosomes as tumor biomarkers due to their stability in body fluids and targeting malignant exosomes' release and/or uptake to inhibit or delay tumor development...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28093991/cancer-nanotechnology-recent-trends-and-developments-in-strategies-for-targeting-cancer-cells-to-improve-cancer-imaging-and-treatment
#7
Jingyao Xu, Xiaoling Zhou, Yifei Li, Yudan Tian
Nanotechnology is a multidisciplinary field, which have the potential to cover applications in many subjects such as biology, chemistry and physics. The combined efforts of these subjects can lead to the successful engineering of nanodevices and nanovectors for targeted delivery and sensing/detection of cancer cells/tissues. The modulation of nanomaterials at surface and bulk level further adds value to this technology and develop strategies for early detection of precancerous and malignant cells from biological fluids...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28075057/two-dimensional-nanomaterials-for-cancer-nanotheranostics
#8
Yongjiu Chen, Yakun Wu, Bingbing Sun, Sijin Liu, Huiyu Liu
Emerging nanotechnologies show unprecedented advantages in accelerating cancer theranostics. Among them, two-dimensional nanomaterials (2DNMs) represent a novel type of material with versatile physicochemical properties that have enabled a new horizon for applications in both cancer diagnosis and therapy. Studies have demonstrated that 2DNMs may be used in diverse aspects, including i) cancer detection due to their high propensity towards tumor markers; ii) molecular imaging for guided tumor therapies, and iii) drug and gene loading, photothermal and photodynamic cancer therapies...
January 11, 2017: Small
https://www.readbyqxmd.com/read/27993133/synthesis-and-functionalization-of-protease-activated-nanoparticles-with-tissue-plasminogen-activator-peptides-as-targeting-moiety-and-diagnostic-tool-for-pancreatic-cancer
#9
Sophie Dobiasch, Szilard Szanyi, Aleko Kjaev, Jens Werner, Albert Strauss, Christian Weis, Lars Grenacher, Katya Kapilov-Buchman, Liron-Limor Israel, Jean-Paul Lellouche, Erica Locatelli, Mauro Comes Franchini, Jennifer Vandooren, Ghislain Opdenakker, Klaus Felix
BACKGROUND: Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed delivery with a suitable target-biomarker to detect early pancreatic ductal adenocarcinoma (PDAC). Promising targets are galectins (Gal), due to their strong expression in and on PDAC-cells and occurrence at early stages in cancer precursor lesions, but not in adjacent normal tissues...
December 19, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27973767/new-advances-in-nanotechnology-based-diagnosis-and-therapeutics-for-breast-cancer-an-assessment-of-active-targeting-inorganic-nanoplatforms
#10
Priscila Falagan-Lotsch, Elissa M Grzincic, Catherine J Murphy
Breast cancer is a major cause of suffering and mortality among women. Limitations in the current diagnostic methods and treatment approaches have led to new strategies to positively impact the survival rates and quality of life of breast cancer patients. Nanotechnology offers a real possibility of mitigating breast cancer mortality by early-stage cancer detection and more precise diagnosis as well as more effective treatments with minimal side effects. The current nanoplatforms approved for breast cancer therapeutics are based on passive tumor targeting using organic nanoparticles and have not provided the expected significant improvements in the clinic...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27924334/a-protein-corona-enabled-blood-test-for-early-cancer-detection
#11
D Caputo, M Papi, R Coppola, S Palchetti, L Digiacomo, G Caracciolo, D Pozzi
Pancreatic cancer is a very aggressive malignancy that is often diagnosed in the advanced stages, with the implication that long-term survivors are extremely rare. Thus, developing new methods for the early detection of pancreatic cancer is an urgent task for current research. To date, nanotechnology offers unprecedented opportunities for cancer therapeutics and diagnosis. The aim of this study is the development of a new pancreatic cancer diagnostic technology based on the exploitation of the nano-bio-interactions between nanoparticles and blood samples...
January 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/27917642/can-nanotechnology-improve-cancer-diagnosis-through-mirna-detection
#12
Roberto Fiammengo
miRNAs are key regulators of gene expression, and alterations in their expression levels correlate with the onset and progression of cancer. Although miRNAs have been proposed as biomarkers for cancer diagnosis, their application in routine clinical praxis is yet to come. Current quantification strategies have limitation, and there is a great interest in developing innovative ones. Since a few years, nanotechnology-based approaches for miRNA quantification are emerging at fast pace but there is urgent need to go beyond the proof-of-concept stage...
January 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27859448/nanotechnology-in-glycomics-applications-in-diagnostics-therapy-imaging-and-separation-processes
#13
REVIEW
Erika Dosekova, Jaroslav Filip, Tomas Bertok, Peter Both, Peter Kasak, Jan Tkac
This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery...
November 15, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#14
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27834798/development-of-an-fpw-biosensor-with-low-insertion-loss-and-high-fabrication-yield-for-detection-of-carcinoembryonic-antigen
#15
Je-Wei Lan, I-Yu Huang, Yu-Cheng Lin, Chang-Yu Lin, Jian-Lin Chen, Chia-Hsu Hsieh
In the last two decades, various flexural plate-wave (FPW)-based biosensors with low phase velocity, low operation frequency, high sensitivity, and short response time, have been developed. However, conventional FPW transducers have low fabrication yield because controlling the thickness of silicon/isolation/metal/piezoelectric multilayer floating thin-plate is difficult. Additionally, conventional FPW devices usually have high insertion loss because of wave energy dissipation to the silicon substrate or outside area of the output interdigital transducers (IDTs)...
November 8, 2016: Sensors
https://www.readbyqxmd.com/read/27824433/preparation-surface-properties-and-therapeutic-applications-of-gold-nanoparticles-in-biomedicine
#16
Yunes Panahi, Majid Mohammadhosseini, Kazem Nejati-Koshki, Azam Jafari Najaf Abadi, Hadi Fallah Moafi, Abolfazl Akbarzadeh, Masoud Farshbaf
Gold nanoparticles (AuNPs) due to their unique properties and manifold surface functionalities have been applied in bio-nanotechnology. The application of GNPs in recent medical and biological research is very extensive. Especially it involves applications such as detection and photothermalysis of microorganisms and cancer stem cells, biosensors; optical bio-imaging and observing of cells and these nanostructures also serve as practical platforms for therapeutic agents. In this review we studied all therapeutic applications of gold nanoparticles in biomedicine, synthesis methods, and surface properties...
February 2017: Drug Research
https://www.readbyqxmd.com/read/27799773/quantum-dot-based-immunofluorescent-imaging-and-quantitative-detection-of-top2a-and-prognostic-value-in-triple-negative-breast-cancer
#17
Hongmei Zheng, Xiang Li, Chuang Chen, Jian Chen, Jinzhong Sun, Si Sun, Liting Jin, Juanjuan Li, Shengrong Sun, Xinhong Wu
BACKGROUND: Topoisomerase 2 alpha (TOP2A) is a key enzyme in DNA replication and a target of various cytotoxic agents including anthracyclines. Previous studies evaluating the predictive and prognostic values of TOP2A in breast cancer are contradictory, likely secondary to the use of both different detection methods and different cutoff thresholds for positive status. Our own studies have previously confirmed the advantages of quantum dot-based nanotechnology for quantitative analysis of biomarkers relative to conventional immunohistochemistry (IHC)...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27784402/-research-progress-in-detection-of-malignant-hematologic-diseases-by-bio-electrochemistry-review
#18
Yu-Jie Wang, Bao-An Chen
Hematologic disease has become a common disease that produces harm and burdens to human individuals today, seriously threatening public health care. Particularly, the damage caused by malignant hematologic disease has been recognized by doctors and patients. However, low cure rate and high recurrence rate are the main issues when treating malignant hematologic disease by current methods. The survival rate could be significantly improved if the early metaphase diagnosis rate could be improved. Therefore, early diagnosis is important for malignant hematologic disease at molecular level...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27746277/precision-targeted-therapy-of-ovarian-cancer
#19
REVIEW
Justin Sapiezynski, Oleh Taratula, Lorna Rodriguez-Rodriguez, Tamara Minko
The review is aimed at describing modern approaches to detection as well as precision and personalized treatment of ovarian cancer. Modern methods and future directions of nanotechnology-based targeted and personalized therapy are discussed.
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27665475/cancer-nanotheranostics-strategies-promises-and-impediments
#20
REVIEW
Moumita Roy Chowdhury, Canan Schumann, Dipita Bhakta-Guha, Gunjan Guha
Cancer has remained one of the most indomitable conundrums for scientists over centuries due to its multifarious etiology. While improved therapeutic and diagnostic approaches have commendably augmented the rate of survival of cancer patients, a holistic riddance from the ailment is still implausible. Hence, further explorations to scout for novel strategies of cancer therapy and diagnosis are necessary. Theranostics (amalgamation of therapy and diagnostics) has emerged as one of the avant-garde strategies, which provides a two-pronged advantage in cancer management...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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