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https://www.readbyqxmd.com/read/29689502/a-robust-electrochemical-immunosensor-based-on-hydroxyl-pillar-5-arene-aunps-g-c-3-n-4-hybrid-nanomaterial-for-ultrasensitive-detection-of-prostate-specific-antigen
#1
Xu Zhou, Long Yang, Xiaoping Tan, Genfu Zhao, Xiaoguang Xie, Guanben Du
Prostate specific antigen (PSA) is the most significant biomarker for the screening of prostate cancer in human serum. However, most methods for the detection of PSA often require major laboratories, precisely analytical instruments and complicated operations. Currently, the design and development of satisfying electrochemical biosensors based on biomimetic materials (e.g. synthetic receptors) and nanotechnology is highly desired. Thus, we focused on the combination of molecular recognition and versatile nanomaterials in electrochemical devices for advancing their analytical performance and robustness...
April 18, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29595962/cross-platform-cancer-cell-identification-using-telomerase-specific-spherical-nucleic-acids
#2
Zhengjie Liu, Jun Zhao, Ruilong Zhang, Guangmei Han, Cheng Zhang, Bianhua Liu, Zhongping Zhang, Ming-Yong Han, Xiaohu Gao
Distinguishing tumor cells from normal cells holds the key to precision diagnosis and effective intervention of cancers. The fundamental difficulties, however, are the heterogeneity of tumor cells and the lack of truly specific and ideally universal cancer biomarkers. Here, we report a concept of tumor cell detection, bypassing the specific genotypic and phenotypic features of different tumor cell types and directly going toward the hallmark of cancer, uncontrollable growth. Combining spherical nucleic acids (SNAs) with exquisitely engineered molecular beacons (SNA beacons, dubbed SNAB technology) is capable of identifying tumor cells from normal cells based on the molecular phenotype of telomerase activity, largely bypassing the heterogeneity problem of cancers...
April 2, 2018: ACS Nano
https://www.readbyqxmd.com/read/29593398/synthesis-and-in-vitro-studies-of-plga-dtx-nanoconjugate-as-potential-drug-delivery-vehicle-for-oral-cancer
#3
Parul Gupta, Manjri Singh, Rajiv Kumar, Jodi Belz, Rishi Shanker, Premendra D Dwivedi, Srinivas Sridhar, Surinder P Singh
Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic- co -glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29570270/cascade-amplification-mediated-in-situ-hot-spot-assembly-for-microrna-detection-and-molecular-logic-gate-operations
#4
Sha Yu, Yingying Wang, Li-Ping Jiang, Sai Bi, Jun-Jie Zhu
MicroRNAs (miRNAs) play important roles in many biological processes and are associated with various diseases, especially cancers. Combination of technological developments such as nanomaterials, functional enzyme-mediated reactions, and DNA nanotechnology holds great potential for high-performance detection of miRNAs in molecular diagnostic systems. In this work, we have fabricated a cascade signal amplification platform through integrating duplex-specific nuclease (DSN)-assisted target recycling with catalytic hairpin assembly (CHA) reaction for the detection of microRNA-141 (miR-141)...
March 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29545463/multivalent-binding-and-biomimetic-cell-rolling-improves-the-sensitivity-and-specificity-of-circulating-tumor-cell-capture
#5
Ja Hye Myung, Michael J Eblan, Joseph M Caster, Sinjung Park, Michael J Poellmann, Kyle Wang, Joel E Tepper, Kevin A Tam, Seth M Miller, Colette Shen, Ronald C Chen, Tian Zhang, Bhishamjit Chera, Andrew Z Wang, Seungpyo Hong
PURPOSE: We aimed to examine the effects of multivalent binding and biomimetic cell rolling on the sensitivity and specificity of circulating tumor cell (CTC) capture. We also investigated the clinical significance of CTCs and their kinetic profiles in cancer patients undergoing radiotherapy (RT) treatment. EXPERIMENTAL DESIGN: Patients with histologically confirmed primary carcinoma undergoing RT, with or without chemotherapy, were eligible for enrollment. Peripheral blood was collected prospectively at up to 5 time points, including prior to RT, at the first week, mid-point and final week of treatment, as well as 4 to 12 weeks after completion of RT...
March 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29534792/aptamer-integrated-dna-nanoassembly-a-simple-and-sensitive-dna-framework-to-detect-cancer-cells
#6
Akram Norouzi, Hadi Ravan, Abbas Mohammadi, Elyas Hosseinzadeh, Mahdieh Norouzi, Tahereh Fozooni
The development of powerful techniques to detect cancer cells at early stages plays a notable role in diagnosing and prognosing cancer patients and reducing mortality. This paper reports on a novel functional DNA nanoassembly capable of detecting cancer cells based on structural DNA nanotechnology. DNA nanoassemblies were constructed by the self-assembly of a DNA concatemer to a plenty of sticky-ended three-way junctions. While an aptamer moiety guided the nanoassembly to the target cancer cell, the peroxidase-mimicking DNAzymes embedded in the nanoassemblies were used as the sensing element to produce colorimetric signals...
August 9, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29525091/graphene-oxide-an-efficient-material-and-recent-approach-for-biotechnological-and-biomedical-applications
#7
REVIEW
Dinesh Pratap Singh, Carlos Eugenio Herrera, Brijesh Singh, Shipra Singh, Rajesh Kumar Singh, Rajesh Kumar
The two-dimensional (2D) derivative of graphite termed graphene has widespread applications in various frontiers areas of nanoscience and nanotechnologies. Graphene in its oxidized form named as graphene oxide (GO) has a mixed structure equipped with various oxygen containing functional groups (epoxy, hydroxyl, carboxylic and carbonyl etc.) provides attachment sites to various biological molecules including protein, deoxyribonucleic acid (DNA), ribonucleic acid (RNA) etc. The attached biological molecules with the help of functional groups make it a promising candidate in research field of biotechnological and biomedical applications...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29524914/recent-progresses-in-dna-nanostructure-based-biosensors-for-detection-of-tumor-markers
#8
REVIEW
Rongrong Huang, Nongyue He, Zhiyang Li
DNA has emerged as a promising biomaterial for assembling a variety of nanostructures based on its programmable base pairing. It also has other remarkable properties including stability, prominent biocompatibility, and can easily be modified with functional groups for further applications. In the past few decades, researchers have established various design rules and assembly technologies to improve the stability and complexity of DNA nanostructures. The detection of cancer-associated biomarkers has significant importance in identifying patients with different clinical stages and also in developing adaptive therapeutic strategies...
March 6, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29510526/nanotechnology-and-glycosaminoglycans-paving-the-way-forward-for-ovarian-cancer-intervention
#9
REVIEW
Yasar Hoosen, Priyamvada Pradeep, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Viness Pillay
Ovarian cancer (OC) has gained a great deal of attention due to its aggressive proliferative capabilities, high death rates and poor treatment outcomes, rendering the disease the ultimate lethal gynaecological cancer. Nanotechnology provides a promising avenue to combat this malignancy by the niche fabrication of optimally-structured nanomedicines that ensure potent delivery of chemotherapeutics to OC, employing nanocarriers to act as "intelligent" drug delivery vehicles, functionalized with active targeting approaches for precision delivery of chemotherapeutics to overexpressed biomarkers on cancer cells...
March 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29489335/radiolabeling-silica-based-nanoparticles-via-coordination-chemistry-basic-principles-strategies-and-applications
#10
Dalong Ni, Dawei Jiang, Emily B Ehlerding, Peng Huang, Weibo Cai
As one of the most biocompatible and well-tolerated inorganic nanomaterials, silica-based nanoparticles (SiNPs) have received extensive attention over the last several decades. Recently, positron emission tomography (PET) imaging of radiolabeled SiNPs has provided a highly sensitive, noninvasive, and quantitative readout of the organ/tissue distribution, pharmacokinetics, and tumor targeting efficiency in vivo, which can greatly expedite the clinical translation of these promising NPs. Encouraged by the successful PET imaging of patients with metastatic melanoma using124 I-labeled ultrasmall SiNPs (known as Cornell dots or C dots) and their approval as an Investigational New Drug (IND) by the United States Food and Drug Administration, different radioisotopes (64 Cu,89 Zr,18 F,68 Ga,124 I, etc...
February 28, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29488022/taribavirin-and-5-fluorouracil-loaded-pegylated-lipid-nanoparticle-synthesis-p38-docking-and-antiproliferative-effects-on-mcf-7-breast-cancer
#11
Ahmed A Abd-Rabou, Dhruba J Bharali, Shaker A Mousa
PURPOSE: Breast cancer is the second most common cause of mortality in women in the United States. Targeted delivery of antitumor breast cancer drugs as a drug-delivery strategy may allow direct delivery into the tumor. Currently, chemotherapy is one of the principle strategies for cancer treatment, but it can have toxic side effects. Nanotechnology attempts to resolve these challenges by loading drugs in nanoparticles, such as solid lipid nanoparticles (SLN). In response to the breast cancer drug 5-fluorouracil (5-FU), p38MAPK signaling has been investigated since the 1990s...
February 27, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29458567/graphene-based-multifunctional-nanomaterials-in-cancer-detection-and-therapeutics
#12
Wenlin Gong, Zixi Hu, Ying Liang, Yiwei Wang, Rong Zheng, Juntao Tan, Zongqiang Lai, Xiaoxue Li, Jieping Li, Xiaoling Lu, Yongxiang Zhao
Nanotechnology for early diagnosis and treatment of malignant tumor is a forefront topic in the international field of biotechnology and medicine. In order to improve the effect of cancer therapy, the timely and accurate detection of the cancer is important and necessary. Graphene and its derivatives have various excellent characteristics. For example, biological sensors based on graphene are good at amplifying detection signals, and its derivatives play an important role in the early diagnosis and cancer therapy...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29434960/targeting-breast-cancer-cells-with-a-cuins2-zns-quantum-dot-labeled-ki-67-bioprobe
#13
Guang Sun, Wanying Xing, Ren Xing, Liu Cong, Sun Tong, Siyao Yu
The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive breast cancer. Ki-67 is a clinically used biomarker for breast cancer diagnosis, treatment and prognosis. Owing to the optical and chemical advantages of QDs, QD-based nanotechnology may aid the construction of a biomedical imaging platform for the study of cancer cell behavior...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29401387/ex-vivo-detection-of-circulating-tumor-cells-from-whole-blood-by-direct-nanoparticle-visualization
#14
Regivaldo G Sobral-Filho, Lindsay DeVorkin, Sarah Macpherson, Andrew Jirasek, Julian J Lum, Alexandre G Brolo
The detection of circulating tumor cells (CTCs) from blood samples can predict prognosis, response to systemic chemotherapy, and metastatic spread of carcinoma. Therefore, approaches for CTC identification is an important aspect of current cancer research. Here, a method for the direct visualization of nanoparticle-coated CTCs under dark field illumination is presented. A metastatic breast cancer cell line (4T1) was transduced with a non-native target protein (Thy1.1). Positive 4T1-Thy1.1 cells incubated with antibody-coated metallic nanoshells appeared overly bright at low magnification, allowing a quick screening of samples and easy visual detection of even single isolated CTCs...
February 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29366804/clinical-utility-of-non-epcam-based-circulating-tumor-cell-assays
#15
R Garland Austin, Tony Jun Huang, Mengxi Wu, Andrew J Armstrong, Tian Zhang
Methods enabling the isolation, detection, and characterization of circulating tumor cells (CTCs) in blood have clear potential to facilitate precision medicine approaches in patients with cancer, not only for prognostic purposes but also for prediction of the benefits of specific therapies in oncology. However, current CTC assays, which capture CTCs based on expression of epithelial cell adhesion molecule (EpCAM), fail to capture cells from de-differentiated tumors and carcinomas undergoing loss of the epithelial phenotype during the invasion/metastatic process...
January 31, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29348534/anti-cancer-activities-of-allyl-isothiocyanate-and-its-conjugated-silicon-quantum-dots
#16
Peng Liu, Mehrnaz Behray, Qi Wang, Wei Wang, Zhigang Zhou, Yimin Chao, Yongping Bao
Allyl isothiocyanate (AITC), a dietary phytochemical in some cruciferous vegetables, exhibits promising anticancer activities in many cancer models. However, previous data showed AITC to have a biphasic effect on cell viability, DNA damage and migration in human hepatoma HepG2 cells. Moreover, in a 3D co-culture of HUVEC with pericytes, it inhibited tube formation at high doses but promoted this at low doses, which confirmed its biphasic effect on angiogenesis. siRNA knockdown of Nrf2 and glutathione inhibition abolished the stimulation effect of AITC on cell migration and DNA damage...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29291161/nanotechnology-based-strategies-for-early-cancer-diagnosis-using-circulating-tumor-cells-as-a-liquid-biopsy
#17
REVIEW
Qinqin Huang, Yin Wang, Xingxiang Chen, Yimeng Wang, Zhiqiang Li, Shiming Du, Lianrong Wang, Shi Chen
Circulating tumor cells (CTCs) are cancer cells that shed from a primary tumor and circulate in the bloodstream. As a form of "tumor liquid biopsy", CTCs provide important information for the mechanistic investigation of cancer metastasis and the measurement of tumor genotype evolution during treatment and disease progression. However, the extremely low abundance of CTCs in the peripheral blood and the heterogeneity of CTCs make their isolation and characterization major technological challenges. Recently, nanotechnologies have been developed for sensitive CTC detection; such technologies will enable better cell and molecular characterization and open up a wide range of clinical applications, including early disease detection and evaluation of treatment response and disease progression...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29290827/local-intratracheal-delivery-of-perfluorocarbon-nanoparticles-to-lung-cancer-demonstrated-with-magnetic-resonance-multimodal-imaging
#18
Lina Wu, Xiaofei Wen, Xiance Wang, Chunan Wang, Xilin Sun, Kai Wang, Huiying Zhang, Todd Williams, Allen J Stacy, Junjie Chen, Anne H Schmieder, Gregory M Lanza, Baozhong Shen
Eighty percent of lung cancers originate as subtle premalignant changes in the airway mucosal epithelial layer of bronchi and alveoli, which evolve and penetrate deeper into the parenchyma. Liquid-ventilation, with perfluorocarbons (PFC) was first demonstrated in rodents in 1966 then subsequently applied as lipid-encapsulated PFC emulsions to improve pulmonary function in neonatal infants suffering with respiratory distress syndrome in 1996. Subsequently, PFC nanoparticles (NP) were extensively studied as intravenous (IV) vascular-constrained nanotechnologies for diagnostic imaging and targeted drug delivery applications...
2018: Theranostics
https://www.readbyqxmd.com/read/29247765/integration-of-biomimicry-and-nanotechnology-for-significantly-improved-detection-of-circulating-tumor-cells-ctcs
#19
Ja Hye Myung, Sin-Jung Park, Andrew Z Wang, Seungpyo Hong
Circulating tumor cells (CTCs) have received a great deal of scientific and clinical attention as a biomarker for diagnosis and prognosis of many types of cancer. Given their potential significance in clinics, a variety of detection methods, utilizing the recent advances in nanotechnology and microfluidics, have been introduced in an effort of achieving clinically significant detection of CTCs. However, effective detection and isolation of CTCs still remain a tremendous challenge due to their extreme rarity and phenotypic heterogeneity...
December 13, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29246318/size-shape-and-sequence-dependent-immunogenicity-of-rna-nanoparticles
#20
Sijin Guo, Hui Li, Mengshi Ma, Jian Fu, Yizhou Dong, Peixuan Guo
RNA molecules have emerged as promising therapeutics. Like all other drugs, the safety profile and immune response are important criteria for drug evaluation. However, the literature on RNA immunogenicity has been controversial. Here, we used the approach of RNA nanotechnology to demonstrate that the immune response of RNA nanoparticles is size, shape, and sequence dependent. RNA triangle, square, pentagon, and tetrahedron with same shape but different sizes, or same size but different shapes were used as models to investigate the immune response...
December 15, 2017: Molecular Therapy. Nucleic Acids
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