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https://www.readbyqxmd.com/read/29216344/prostate-cancer-updates-on-current-strategies-for-screening-diagnosis-and-clinical-implications-of-treatment-modalities
#1
Jing-Yan Tian, Feng-Jun Guo, Guo-You Zheng, Aamir Ahmad
Prostate cancer is the most common cancer in men by way of diagnosis, and a leading cause of cancer-related deaths. Early detection and intervention remains key to its optimum clinical management. This review provides the most updated information on the recent methods of prostate cancer screening, imaging and treatment modalities. Wherever possible, clinical trial data has been supplemented to provide a comprehensive overview of current prostate cancer research and development. Considering the recent success of immunotherapy in prostate cancer, we discuss cell, DNA and viruses based, as well as combinatorial immunotherapeutic strategies in detail...
December 5, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29189149/theranostic-aspects-treatment-of-cancer-by-nanotechnology
#2
Bidisha Sarkar, Priyankar Paira
Theranostic agents or theranostic imaging as its name suggests is a combination of two terms-'diagnosis' & 'therapy'. Efforts are being made to combine both the terms into clinical formulations. This theranostic imaging is found to be very much significant to complex diseases like cancer and proliferative tumors specially now that protionic and genomic profiling can provide an accurate 'fingerprint' of each tumor, with all such kinds of informations theranostic agents can be designed in such a way that it is specific in its action and selective towards the cancer cells only, without causing any adverse effects on the normal tissue cells...
November 29, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29186662/ultrasmall-in-nano-approach-enabling-the-translation-of-metal-nanomaterials-to-clinics
#3
Domenico Cassano, Salvador Pocoví-Martínez, Valerio Voliani
Currently, nanomaterials are of widespread use in daily commercial products. However, the most promising and potentially impacting application is in the medical field. In particular, nano-sized noble metals hold the promise to shift the current medical paradigms for the detection and therapy of neoplasms thanks to the: i) localized surface plasmon resonances (LSPRs), ii) high electron density, and iii) suitability for straightforward development of all-in-one nano-platforms. Nonetheless, there is still no clinically approved noble metal nanomaterial for cancer therapy/diagnostic...
November 29, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29161677/nanotechnology-based-recent-approaches-for-sensing-and-remediation-of-pesticides
#4
REVIEW
Deepak Rawtani, Nitasha Khatri, Sanjiv Tyagi, Gaurav Pandey
Pesticides are meant to control and destroy the pests and weeds. They are classified into different categories on the basis their origin and type of pest they target. Chemical pesticides such as insecticides, herbicides and fungicides are commonly used in agricultural fields. However, the excessive use of these agrochemicals have adverse effects on environment such as reduced population of insect pollinators, threat to endangered species and habitat of birds. Upon consumption; chemical pesticides also cause various health issues such as skin, eye and nervous system related problems and cancer upon prolonged exposure...
November 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29149830/diagnostic-devices-for-circulating-biomarkers-detection-and-quantification
#5
Chiara Bedin, Sara Crotti, Ennio Tasciotti, Marco Agostini
Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely in centralized laboratory testing. The development of small, fast and simple to use medical device that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotechnology. To develop diagnostic devices for cancer detection, nanomaterials-based systems have significant advantages over current conventional approaches in terms of simplicity, sensitivity, specificity and rapidity...
November 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29120818/near-infrared-dye-conjugated-oxidative-stress-amplifying-polymer-micelles-for-dual-imaging-and-synergistic-anticancer-phototherapy
#6
Wonseok Yang, Joungyoun Noh, Hoyeon Park, Sian Gwon, Berwin Singh, Chulgyu Song, Dongwon Lee
The recent advances in nanotechnology have led to the development of smart nanomaterials that combine diagnostic and therapeutic functions and provide synergistic anticancer effects through the combination of different treatment modalities. Here, we report a promising theranostic nanoconstruct that can translate into multiple functionalities: fluorescence/photoacoustic imaging, acid-triggered generation of ROS (reactive oxygen species), heat and singlet oxygen production under near infrared (NIR) laser irradiation, and coupling oxidative anticancer therapy to dual imaging-guided photothermal/photodynamic therapy...
October 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29097909/molecular-imaging-of-cancer-with-nanoparticle-based-theranostic-probes
#7
REVIEW
Ying-Yu Ma, Ke-Tao Jin, Shi-Bing Wang, Hui-Ju Wang, Xiang-Min Tong, Dong-Sheng Huang, Xiao-Zhou Mou
Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29090067/magnetic-iron-oxide-nanoparticles-as-t2-mr-imaging-contrast-agent-for-detection-of-breast-cancer-mcf-7-cell
#8
Pegah Moradi Khaniabadi, Daryoush Shahbazi-Gahrouei, Mohammad Suhaimi Jaafar, Amin Malik Shah Abdul Majid, Bita Moradi Khaniabadi, Saghar Shahbazi-Gahrouei
BACKGROUND: Advances of nanotechnology have led to the development of nano-materials with both potential diagnostic and therapeutic applications. Among them, Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) have received particular attention. Modified EDC coupling fraction was used to fabricate the SPION-C595 as an MR imaging contrast agent for breast cancer detection in early stages. METHODS: Nanoprobe characterization was confirmed using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy with Energy Dispersive X-Ray Spectroscopy (SEM-EDAX), and Photon Correlation Spectroscopy (PCS)...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29033548/the-new-era-of-nanotechnology-an-alternative-to-change-cancer-treatment
#9
REVIEW
Ancuta Jurj, Cornelia Braicu, Laura-Ancuta Pop, Ciprian Tomuleasa, Claudia Diana Gherman, Ioana Berindan-Neagoe
In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29026204/engineering-and-physical-sciences-in-oncology-challenges-and-opportunities
#10
REVIEW
Michael J Mitchell, Rakesh K Jain, Robert Langer
The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology...
November 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28966883/micrornas-in-cancer-challenges-and-opportunities-in-early-detection-disease-monitoring-and-therapeutic-agents
#11
Namita Chatterjee, Shushan Rana, Cristina Espinosa-Diez, Sudarshan Anand
PURPOSE OF REVIEW: The goals of this review are to examine the usefulness of miRNAs as diagnostic and prognostic biomarkers for cancer and to evaluate the applicability of miRNAs as cancer therapeutics. RECENT FINDINGS: Examination of miRNA milieu from body fluids offers a new alternative for quick, affordable and easy analysis of disease status in patients. Blood-based exosomal miRNAs have increased stability and are an excellent choice for clinical cancer diagnostics and prognostics...
March 2017: Current Pathobiology Reports
https://www.readbyqxmd.com/read/28957779/a-sensitive-liquid-chromatography-electrospray-tandem-mass-spectroscopy-method-for-simultaneous-quantification-of-a-disulfide-bond-doxorubicin-conjugation-prodrug-and-activated-doxorubicin-application-to-cellular-pharmacokinetic-and-catabolism-studies
#12
Nan Zheng, Xing Wang, Yaoqi Wang, Guobing Xu, Hua Zhang, Wenbing Dai, Bing He, Qiang Zhang, Jiafu Ji, Xueqing Wang
In recent years, drug conjugates as a prodrug strategy have been widely studied, especially combined with nanotechnology. Disulfide-linked doxorubicin drug-drug conjugate (DOX-S-S-DOX) nanoparticles, have recently been developed as a doxorubicin prodrug nanoparticles with greater anticancer activity and less toxicity than doxorubicin in vivo, while its intracellular kinetics and metabolism is unclear which may provide us with a deeper understanding of its pharmacological mechanism and antitumor effect. Hence, in this study, a rapid and sensitive ultra high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to detect doxorubicin (DOX) activated from DOX-S-S-DOX, as well as the prodrug itself in human breast cancer tumor cells (MCF-7)...
October 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28957706/shifting-paradigm-of-cancer-diagnoses-in-clinically-relevant-samples-based-on-miniaturized-electrochemical-nanobiosensors-and-microfluidic-devices
#13
REVIEW
Kuldeep Mahato, Ashutosh Kumar, Pawan Kumar Maurya, Pranjal Chandra
Cancer is one of leading causes of death in the world and occurs in more than two hundred types according to the National Cancer Institute. Its early diagnosis has been remained a prime focus amongst scientists and clinicians since long, not only to understand the complications but also to mitigate its chance of further proliferation. Nowadays, tremendous advances in nanotechnology-empowered diagnostics are serving a substantial input to identify biomarkers associated with various cancers. These biomarkers are found in different forms including overexpressed proteins/surface antigens, metabolites, miRNA, and the entire cell as well...
September 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28948388/effect-of-gold-nanoparticles-on-radiation-doses-in-tumor-treatment-a-monte-carlo-study
#14
H A Al-Musywel, A Laref
Radiotherapy is an extensively used treatment for most tumor types. However, ionizing radiation does not discriminate between cancerous and normal cells surrounding the tumor, which can be considered as a dose-limiting factor. This can lead to the reduction of the effectiveness of tumor cell eradication with this treatment. A potential solution to this problem is loading the tumor with high-Z materials prior to radiotherapy as this can induce higher toxicity in tumor cells compared to normal ones. New advances in nanotechnology have introduced the promising use of heavy metal nanoparticles to enhance tumor treatment...
December 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28863308/clickable-and-imageable-multiblock-polymer-micelles-with-magnetically-guided-and-peg-switched-targeting-and-release-property-for-precise-tumor-theranosis
#15
Jing Wei, Xiaoyu Shuai, Rui Wang, Xueling He, Yiwen Li, Mingming Ding, Jiehua Li, Hong Tan, Qiang Fu
Targeted delivery of therapeutics and diagnostics using nanotechnology holds great promise to minimize the side effects of conventional chemotherapy and enable specific and real-time detection of diseases. To realize this goal, we report a clickable and imageable nanovehicle assembled from multiblock polyurethanes (MPUs). The soft segments of the polymers are based on detachable poly(ethylene glycol) (PEG) and degradable poly(ε-caprolactone) (PCL), and the hard segments are constructed from lysine- and cystine-derivatives bearing reduction-responsive disulfide linkages and click-active alkynyl moieties, allowing for post-conjugation of targeting ligands via a click chemistry...
August 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28835943/dna-tetrahedron-nanostructures-for-biological-applications-biosensors-and-drug-delivery
#16
REVIEW
Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang, Kemin Wang
With the rapid development of DNA nanotechnology, various DNA nanostructures with different shapes and sizes have been self-assembled using "bottom-up" fabrication strategies and applied to a wide range of fields such as biosensors, drug delivery and tools for molecular biology. As a classical and simple polyhedron, DNA tetrahedron can be easily synthesised by a one-step assembly. Due to the excellent biocompatibility and cellular permeability, it provides a universal and promising platform to construct a series of biosensors and drug delivery systems for living cells studies...
August 24, 2017: Analyst
https://www.readbyqxmd.com/read/28806615/graphene-gold-based-nanocomposites-applications-in-cancer-diseases-efficient-detection-and-therapeutic-tools
#17
REVIEW
Lina A Al-Ani, Mohammed A AlSaadi, Farkaad A Kadir, Najihah M Hashim, Nurhidayatullaili M Julkapli, Wageeh A Yehye
Early detection and efficient treatment of cancer disease remains a drastic challenge in 21st century. Throughout the bulk of funds, studies, and current therapeutics, cancer seems to aggressively advance with drug resistance strains and recurrence rates. Nevertheless, nanotechnologies have indeed given hope to be the next generation for oncology applications. According to US National cancer institute, it is anticipated to revolutionize the perspectives of cancer diagnosis and therapy. With such success, nano-hybrid strategy creates a marvelous preference...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28745363/novel-nanosensing-technologies-for-exosome-detection-and-profiling
#18
REVIEW
Hyungsoon Im, Kyungheon Lee, Ralph Weissleder, Hakho Lee, Cesar M Castro
Exosomes have recently emerged as highly promising cancer biomarkers because they are abundant in biofluids, carry proteins and RNA reflecting their originating cells and are stable over weeks. Beyond abundance and stability, detailed exosome analyses could be clinically useful for diagnosing and profiling cancers. Despite their clinical potential, simple, reliable and sensitive approaches for rapidly quantifying exosomes and their molecular information has been challenging. Therefore, there is a clear need to develop next-generation sensing technologies for exosome detection and analysis...
August 22, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28722430/multi-amplified-sensing-of-microrna-by-a-small-dna-fragment-driven-enzymatic-cascade-reaction
#19
Eunjung Kim, Philip D Howes, Spencer W Crowder, Molly M Stevens
Combining technological developments such as nanomaterials, DNA nanotechnology, and functional enzymes has great potential to facilitate next generation high performance molecular diagnostic systems. In this work, we describe a microRNA (miRNA) detection assay that combines target recycling and isothermal amplification in an elegantly designed enzyme-mediated cascade reaction. Target recycling is driven by the action of duplex-specific nuclease (DSN), resulting in highly amplified translation of input miRNA to short output DNA fragments...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28590117/nanotechnology-enhanced-no-wash-biosensors-for-in-vitro-diagnostics-of-cancer
#20
Xiaolin Huang, Yijing Liu, Bryant Yung, Yonghua Xiong, Xiaoyuan Chen
In vitro biosensors have been an integral component for early diagnosis of cancer in the clinic. Among them, no-wash biosensors, which only depend on the simple mixing of the signal generating probes and the sample solution without additional washing and separation steps, have been found to be particularly attractive. The outstanding advantages of facile, convenient, and rapid response of no-wash biosensors are especially suitable for point-of-care testing (POCT). One fast-growing field of no-wash biosensor design involves the usage of nanomaterials as signal amplification carriers or direct signal generating elements...
June 27, 2017: ACS Nano
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