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Hypertensive disorders of pregnancy

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https://www.readbyqxmd.com/read/28428695/increased-oxidatively-modified-forms-of-albumin-in-association-with-decreased-total-antioxidant-activity-in-different-types-of-hypertensive-disorders-of-pregnancy
#1
Jyothi M P D'souza, Sindhu Harish, Vinitha Ramanath Pai, Chitra Shriyan
Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28427374/prenatal-determinants-of-physical-activity-and-cardiorespiratory-fitness-in-adolescence-northern-finland-birth-cohort-1986-study
#2
Marjaana Tikanmäki, Tuija Tammelin, Marja Vääräsmäki, Marika Sipola-Leppänen, Satu Miettola, Anneli Pouta, Marjo-Riitta Järvelin, Eero Kajantie
BACKGROUND: Lower levels of physical activity and cardiorespiratory fitness are key risk factors of chronic adult diseases. Physical activity and cardiorespiratory fitness are predicted by birth weight, but the underlying parental and pregnancy-related factors remain largely unknown. We examined how prenatal determinants are associated with physical activity and cardiorespiratory fitness in adolescence. METHODS: Of the 16-year-old members of the population-based Northern Finland Birth Cohort 1986 (NFBC 1986), 6682 singletons with no major physical disability reported their amount of physical activity outside school hours, and 4706 completed a submaximal cycle ergometer test assessing cardiorespiratory fitness...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28424221/association-between-fetal-congenital-heart-defects-and-maternal-risk-of-hypertensive-disorders-of-pregnancy-in-the-same-pregnancy-and-across-pregnancies
#3
Heather A Boyd, Saima Basit, Ida Behrens, Elisabeth Leirgul, Henning Bundgaard, Jan Wohlfahrt, Mads Melbye, Nina Øyen
Background -Pregnant women carrying fetuses with heart defects and women with hypertensive disorders of pregnancy both often exhibit angiogenic imbalances, suggesting that the same mechanisms are involved in the etiology of the former and the pathophysiology of the latter. We conducted a register-based cohort study to determine whether offspring congenital heart defects are associated with an increased risk of hypertensive disorders of pregnancy, and whether the mechanisms driving any association are primarily maternal or fetal...
April 19, 2017: Circulation
https://www.readbyqxmd.com/read/28419848/toll-like-receptor-activation-vascular-endothelial-function-and-hypertensive-disorders-of-pregnancy
#4
REVIEW
Dakshnapriya Balasubbramanian, Catalina A Lopez Gelston, Brett M Mitchell, Piyali Chatterjee
Aberrant innate immune system activation in the mother contributes greatly to the development of hypertension during pregnancy. Numerous groups have elicited vascular inflammation, endothelial dysfunction, and hypertension in animals during gestation by directly activating Toll-like receptors. Additionally, several experimental therapies that reduce pro-inflammatory immune cells and cytokines restore vascular endothelial function and normalize blood pressure. This review will summarize the research demonstrating that an excessive maternal innate immune response is sufficient to cause vascular inflammation and endothelial dysfunction, which contributes to the development of hypertension during pregnancy...
April 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28417507/understanding-the-roots-of-health-inequalities-requires-new-methods
#5
Shawn Walker
It is easy to teach health care professionals and students to follow a guideline, tricky to teach them to become aware of unconscious biases and assumptions which may influence how they execute that guideline. Substandard care may be easily recognised in retrospect, but understanding how and why it continues to happen, to some populations more than others, is key to reducing such disparities. Hypertensive disorders of pregnancy affect women of immigrant populations more often and with worse outcomes than native residents of industrialised countries...
April 17, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28409499/use-of-placental-vascularization-indices-and-uterine-artery-peak-systolic-velocity-in-early-detection-of-pregnancies-complicated-by-gestational-diabetes-chronic-or-gestational-hypertension-and-preeclampsia-at-risk
#6
Ábel T Altorjay, Andrea Surányi, Tibor Nyári, Gábor Németh
AIM: We aimed to investigate correlations between uterine artery peak systolic velocity (AUtPSV), and placental vascularization in groups of normal blood pressure (NBP) and hypertensive disorders of pregnancy (chronic hypertension (CHT), gestational hypertension (GHT) and preeclampsia (PE)) alone or in combination with gestational diabetes mellitus (GDM), and hypothesized that AUtPSV rises when GDM complicates pregnancy hypertension. METHODS: Placental 3-dimensional power Doppler indices, such as vascularization index (VI), flow index (FI), and vascularization-flow index (VFI), and uterine artery peak systolic velocity (AUtPSV) were measured in CHT (N=43), CHT+GDM (N=15), GHT (N=57), GHT+GDM (N=23) and PE (N=17) pregnancies, and compared to NBP (N=109)...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28401531/exercise-during-pregnancy-and-risk-of-gestational-hypertensive-disorders-a-systematic-review-and-meta-analysis
#7
Elena Rita Magro-Malosso, Gabriele Saccone, Mariarosaria Di Tommaso, Amanda Roman, Vincenzo Berghella
Gestational hypertensive disorders, including gestational hypertension and preeclampsia, are one of the leading causes of maternal morbidity and mortality. The aim of our study was to evaluate the effect of exercise during pregnancy on the risk of gestational hypertensive disorders MATERIAL AND METHODS: Electronic databases were searched from their inception to February 2017. Selection criteria included only randomized controlled trials of uncomplicated pregnant women assigned before 23 weeks to an aerobic exercise regimen or not...
April 12, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28399439/maternal-and-pregnancy-related-factors-affecting-human-milk-cytokines-among-peruvian-mothers-bearing-low-birth-weight-neonates
#8
Mara Zambruni, Alex Villalobos, Anoma Somasunderam, Sarah Westergaard, Maitreyee Nigalye, Christie G Turin, Jaime Zegarra, Sicilia Bellomo, Erik Mercado, Theresa J Ochoa, Netanya S Utay
Several cytokines have been detected in human milk but their relative concentrations differ among women and vary over time in the same person. The drivers of such differences have been only partially identified, while the effect of luminal cytokines in the fine-regulation of the intestinal immune system is increasingly appreciated. The aim of this study was to investigate the associations between obstetrical complications and human milk cytokine profiles in a cohort of Peruvian women giving birth to Low Birth Weight (LBW) infants...
April 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28388642/association-of-maternal-hypertensive-disorders-with-retinopathy-of-prematurity-a-systematic-review-and-meta-analysis
#9
TingTing Zhu, Li Zhang, FengYan Zhao, Yi Qu, Dezhi Mu
BACKGROUD: The role of maternal hypertensive disorders in pregnancy (HDP) in the development of retinopathy of prematurity (ROP) is unclear. METHODS: Studies were retrieved through literature searches in PubMed, EMBASE, Web of Science and the Cochrane Library up to May 5, 2016 without language restrictions. Cohort or case-control studies that reported the association of maternal hypertensive disorders and retinopathy of prematurity were eligible. Either a fixed- or a random-effects model was used to calculate the overall combined risk estimates...
2017: PloS One
https://www.readbyqxmd.com/read/28386955/adult-pre-pregnancy-weight-change-and-risk-of-developing-hypertensive-disorders-in-pregnancy
#10
Akilew A Adane, Gita D Mishra, Leigh R Tooth
BACKGROUND: While the association of pre-pregnancy body mass index (BMI) and hypertensive disorders in pregnancy (HDP) is well documented, little is known about the relationship between pre-pregnancy weight change and HDP. We examined the impact of adult pre-pregnancy weight change on the development of HDP. METHODS: We included 2914 women, surveyed about every three years since 1996, from the 1973-78 cohort of the Australian Longitudinal Study on Women's Health...
April 7, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28384202/plasma-cross-gestational-sphingolipidomic-analyses-reveal-potential-first-trimester-biomarkers-of-preeclampsia
#11
Aneta Dobierzewska, Sony Soman, Sebastian E Illanes, Andrew J Morris
INTRODUCTION: Preeclampsia (PE) is a gestational disorder, manifested in the second half of pregnancy by maternal hypertension, proteinuria and generalized edema. PE is a major cause of maternal and fetal morbidity and mortality, accounting for nearly 40% of all premature births worldwide. Bioactive sphingolipids are emerging as key molecules involved in etiopathogenesis of PE, characterized by maternal angiogenic imbalance and symptoms of metabolic syndrome. The aim of this study was to compare the cross-gestational profile of circulating bioactive sphingolipids in maternal plasma from preeclamptic (PE) versus normotensive control (CTL) subjects with the goal of identifying sphingolipids as candidate first trimester biomarkers of PE for early prediction of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28383382/maternal-cardiovascular-mortality-in-illinois-2002-2011
#12
Joan Briller, Abigail R Koch, Stacie E Geller
OBJECTIVE: To describe the demographic characteristics of women in Illinois who died from cardiovascular disease during pregnancy or up until 1 year postpartum, addressing specific etiologies, timing of death, proportion of potentially preventable mortality, and factors associated with preventability. METHODS: This is a retrospective analysis from the Illinois Department of Public Health Maternal Mortality Review process using International Classification of Diseases, 9th Revision codes that attributed cardiovascular disease as the immediate or underlying cause of maternal death in Illinois from 2002 to 2011...
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28381873/from-apelin-to-exercise-emerging-therapies-for-management-of-hypertension-in-pregnancy
#13
Jeffrey S Gilbert
Studies over the last couple of decades have provided exciting new insights into mechanisms underlying the pathogenesis of preeclampsia. In addition, several novel and innovative molecules and ideas for management of the syndrome have also come forth. While our basic understanding of the initiating events of preeclampsia continues to be placental ischemia/hypoxia stimulating the release of a variety of factors from the placenta that act on the cardiovascular and renal systems, the number of candidate pathways for intervention continues to increase...
April 6, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28378235/the-impact-of-pregnancy-on-headache-evaluation-in-the-emergency-department-a-retrospective-cohort-study
#14
Ian Waldman, Stephen Wagner, Kristine Posadas, Timothy A Deimling
BACKGROUND: Headache is one of the most common emergency department complaints with three million visits annually in the USA. This is further complicated with 30% of those emergency visits being for a hypertensive disorder of pregnancy. There is no currently well-established guideline for diagnostic imaging with a common concern being ionizing radiation exposure in pregnancy. The purpose of this study was to assess the difference in imaging studies ordered for pregnant and non-pregnant patients who reported to a tertiary care emergency department with headache...
April 5, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28369876/a-systematic-review-and-meta-analysis-of-hypocalciuria-in-pre-eclampsia
#15
REVIEW
Kristen M McMaster, Andrew M Kaunitz, Prardhana Burbano de Lara, Luis Sanchez-Ramos
BACKGROUND: Small observational studies have demonstrated that hypocalciuria is associated with pre-eclampsia. OBJECTIVES: To compare urinary calcium excretion in pre-eclampsia, gestational hypertension, and chronic hypertension with that in normotensive pregnancies. SEARCH STRATEGY: Online databases were searched through February 2016 using medical subject headings "calcium homeostasis," "calcium excretion," "hypocalciuria," and "pre-eclampsia...
March 31, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28366706/-maternal-and-neonatal-outcomes-according-to-gestational-weight-gain-in-twin-pregnancies-are-the-iom-guidelines-associated-with-better-issues
#16
O Pécheux, C Garabedian, S Mizrahi, S Cordiez, S Deltombe, P Deruelle
OBJECTIVE: Our objective was to evaluate the relevance of the Institute of medicine (IOM) guidelines of weight gain during twin pregnancies, published in 2009. METHODS: We systematically reviewed the data from Medline and the Cochrane Library databases. We only selected the articles which studied the neonatal and maternal outcomes according to maternal gestational weight gain (GWG), depending on the prepregnancy BMI (body mass index). Five clinical parameters had been mainly studied: gestational hypertensive disorders (gestational hypertension and preeclampsia), gestational diabetes mellitus (GDM), preterm births, and birth weights...
March 30, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28365201/pregnancy-after-bariatric-surgery-balancing-risks-and-benefits
#17
REVIEW
Anne-Marie Carreau, Mélanie Nadeau, Simon Marceau, Picard Marceau, S John Weisnagel
The majority of bariatric surgeries in Canada are performed in women of reproductive age. Clinicians encounter more and more often pregnancies that occur after bariatric surgeries. The appropriate management and education of women who want to conceive after bariatric surgery is still unclear due to the lack of consistent data about maternal and neonatal outcomes following bariatric surgery. Maternal obesity during pregnancy confers a higher risk for gestational diabetes, hypertensive disorders, congenital malformations, prematurity and perinatal mortality...
March 29, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28360187/growth-throughout-childhood-of-children-born-growth-restricted
#18
Fenny Beukers, Joost Rotteveel, Mirjam M van Weissenbruch, Wessel Ganzevoort, Johannes B van Goudoever, Aleid G van Wassenaer-Leemhuis
OBJECTIVE: Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds true for FGR. Our aim was to study postnatal growth until age 12.5 years in a cohort of children born FGR due to early onset placental insufficiency, and its relation to FGR severity...
March 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28348564/lower-serum-vitamin-d-metabolite-levels-in-relation-to-circulating-cytokines-chemokines-and-metabolic-hormones-in-pregnant-women-with-hypertensive-disorders
#19
Ramu Adela, Roshan M Borkar, Navneeta Mishra, Murali Mohan Bhandi, Gayatri Vishwakarma, B Aparna Varma, Srinivas Ragampeta, Sanjay K Banerjee
The aim of this study was to investigate whether lower serum vitamin D metabolite levels were associated with altered cytokine/chemokine and metabolic hormone levels in three different hypertensive disorders in pregnancy (HDP). Healthy pregnancy (n = 30) and hypertensive disorders in pregnancy (HDP) (n = 30), i.e., gestational hypertension (GH), preeclampsia (PE), and eclampsia (EC) subjects were enrolled. Vitamin D metabolites were measured by UPLC/APCI/HRMS method. Circulatory 27 cytokines/chemokines and 10 metabolic hormones were measured...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28344956/maternal-serum-placental-growth-factor-and-pregnancy-associated-plasma-protein-a-measured-in-the-first-trimester-as-parameters-of-subsequent-pre-eclampsia-and-small-for-gestational-age-infants-a-prospective-observational-study
#20
Kyung Uk Sung, Jeong A Roh, Kyung Jin Eoh, Eui Hyeok Kim
OBJECTIVE: To examine the first-trimester maternal serum placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A) levels in pregnancies associated with pre-eclampsia (PE) or small-for-gestational-age (SGA) infants, and determine the predictive accuracy of PlGF and of PAPP-A for either PE or SGA infants. METHODS: This prospective, observational study included 175 pregnant women, and of these women, due to participant withdrawal or loss to follow-up, delivery data were collected from the medical records of 155 women, including 4 who had twin pregnancies...
March 2017: Obstetrics & Gynecology Science
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