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Hypertensive disorders of pregnancy

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https://www.readbyqxmd.com/read/28087411/aspirin-prevents-tnf-%C3%AE-induced-endothelial-cell-dysfunction-by-regulating-the-nf-%C3%AE%C2%BAb-dependent-mir-155-enos-pathway-role-of-a-mir-155-enos-axis-in-preeclampsia
#1
Joohwan Kim, Kyu-Sun Lee, Ji-Hee Kim, Dong-Keon Lee, Minsik Park, Seunghwan Choi, Wonjin Park, Suji Kim, Yoon Kyoung Choi, Jong Yun Hwang, Jongseon Choe, Moo-Ho Won, Dooil Jeoung, Hansoo Lee, Sungwoo Ryoo, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim
Preeclampsia is an inflammatory disease with endothelial cell dysfunction that occurs via decreased endothelial nitric oxide synthase/nitric oxide (eNOS/NO) activity. Aspirin reduces the incidence of hypertensive pregnancy complications. However, the underlying mechanism has not been clearly explained. Here, we found that tumor necrosis factor (TNF)-α, microRNA (miR)-155, and eNOS levels as well as endothelial redox phenotype were differentially regulated in preeclamptic patients, implying the involvement of TNF-α- and redox signal-mediated miR-155 biogenesis and eNOS downregulation in the pathogenesis of preeclampsia...
January 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28076672/prenatal-psychostimulant-and-antidepressant-exposure-and-risk-of-hypertensive-disorders-of-pregnancy
#2
D Jeffrey Newport, Amy L Hostetter, Sarah H Juul, Sunny M Porterfield, Bettina T Knight, Zachary N Stowe
OBJECTIVE: To investigate the association, if any, of prenatal mental illness and psychotropic exposure with the risk of hypertensive disorders of pregnancy (HDP). METHODS: A case-cohort analysis was conducted of 686 pregnant women participating in prospective, longitudinal observational studies in a tertiary referral center between January 1998 and May 2012. Risk estimates were produced using multivariate logistic regression modeling. Medication- and diagnosis-specific data were utilized to conduct post hoc confirmatory analyses of the risk estimates...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28074637/moderately-elevated-blood-pressure-during-pregnancy-and-odds-of-hypertension-later-in-life-the-pouchmoms-longitudinal-study
#3
Galit Levi Dunietz, Kelly L Strutz, Claudia Holzman, Yan Tian, David Todem, Bertha L Bullen, Janet M Catov
OBJECTIVE: Hypertensive disorders in pregnancy signal an increased risk of cardiovascular disease for women. However, future hypertension risk among pregnant women with moderately elevated blood pressure (BP) is unknown. We examined associations among moderately elevated BP or hypertensive disorders during pregnancy and later prehypertension or hypertension. DESIGN: Longitudinal cohort study. SETTING: Five communities in Michigan, USA. SAMPLE: Data are from pregnant women enrolled in the Pregnancy Outcomes and Community Health Study...
January 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28071857/risk-of-hypertensive-disorders-in-pregnancy-following-assisted-reproductive-technology-overview-and-meta-analysis
#4
Costas Thomopoulos, George Salamalekis, Konstantinos Kintis, Iliana Andrianopoulou, Helena Michalopoulou, George Skalis, Stefanos Archontakis, Ourania Argyri, Costas Tsioufis, Thomas K Makris, Emmanuel Salamalekis
The extent of the increased risk of pregnancy hypertensive disorders following assisted reproductive technology (ART) was investigated. PubMed and the Cochrane Collaboration Library were used as data sources to identify and select longitudinal cohorts comparing pregnancies following ART with spontaneously conceived pregnancies, between 1978 and June 2016. Risk ratios and 95% confidence intervals (CIs) of three outcomes, ie, gestational hypertension (GH), preeclampsia (PE), and their sum (PHD), were calculated...
November 7, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28069909/pregnancy-increases-stroke-risk-up-to-one-year-postpartum-and-reduces-long-term-risk
#5
Chun-An Cheng, Jiunn-Tay Lee, Hung-Che Lin, Hui-Chen Lin, Chi-Hsiang Chung, Fu-Huang Lin, Chang-Huei Tsao, Yung-Fu Wu, Wu-Chien Chien, Hung-Wen Chiu
BackgroundThe incidence of stroke in pregnant women is low but trending upward. There are few studies of the topic in women of Asian ethnicity.AimWe aim to evaluate stroke risk in Asian women during and after pregnancy.DesignUsing the Taiwan National Health Insurance database (NHIRD), we designed a retrospective study that included 18-45-year-old pregnant women between the years 2000 and 2010. We selected a 1:1 age-matched control group of non-pregnant women. The endpoint was any type of stroke during pregnancy or the postpartum period; otherwise, the patients were tracked until December 31, 2010...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28069864/hydralazine-is-involved-in-tele-methylhistamine-metabolism-by-inhibiting-monoamine-oxidase-b-in-pregnancy-associated-hypertensive-mice
#6
Shohei Kawasaki, Koichiro Kako, Yusuke Nagashima, Akihiko Kanou, Junji Ishida, Akiyoshi Fukamizu
Hypertensive disorders of pregnancy globally affect 6-8% of gestation and remain a major cause of both foetal and maternal morbidity and mortality. However, the antihypertensive medications for the patients of this disease are strictly limited due to the teratogenic potentials. Here, we found that tele-methylhistamine (tMH) increased in response to the administration of hydralazine (Hdz), a vasodilative agent, in the pregnancy-associated hypertensive (PAH) mice. Hdz abrogated the degradation of tMH catalyzed by monoamine oxidase B (MAO-B) in vitro These results suggested that Hdz inhibited the MAO-B activity and consequently tMH increased in the maternal circulation of PAH mice...
January 7, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28065366/-characteristics-of-induced-labors-at-marqu%C3%A3-s-de-valdecilla-university-hospital
#7
Marta González-Maestro, Izaskun Laurrieta-Saiz, Casandra García-González, Marta López-Mirones, Oihane Terán-Muñoz, Alicia Alonso-Salcines
OBJECTIVE: Induction of labor (IOL) is a common obstetric practice which has increased in recent decades. The main objective of this study is to describe the characteristics of induced labor at Marqués de Valdecilla University Hospital. METHOD: A descriptive, retrospective study was performed between January 1st and April 30t(h) of 2014, by reviewing medical histories. A standardised registration has been used to collect data. RESULTS: There were a total of 376 IOL, the incidence was 35...
January 3, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28059847/angiogenic-and-antiangiogenic-markers-for-prediction-and-risk-classification-of-preeclampsia
#8
Amol K Malshe, Baha M Sibai
Preeclampsia is a pregnancy-specific hypertensive disorder with multisystem involvement and is a significant cause of obstetric morbidity and mortality worldwide. A major issue in the treatment of preeclampsia stems from its still significant rates of misclassification and misdiagnosis. Angiogenic factors have been speculated as a possible diagnostic modality due to a perceived imbalance in angiogenesis in preeclampsia. Factors currently studied include soluble fms-like protein kinase 1 and placental growth factor...
January 4, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28056855/symptomatic-congenital-cytomegalovirus-disease-following-non-primary-maternal-infection-a-retrospective-cohort-study
#9
Eran Hadar, Elizabeta Dorfman, Ron Bardin, Rinat Gabbay-Benziv, Jacob Amir, Joseph Pardo
BACKGROUND: Scarce data exist about screening, diagnosis and prognosis of non-primary Cytomegalovirus (CMV) during pregnancy. We aimed to examine antenatal diagnosis of maternal non-primary CMV infection and to identify risk factors for congenial CMV disease. METHODS: Retrospective cohort of 107 neonates with congenital symptomatic CMV infection, following either primary (n = 95) or non-primary (n = 12) maternal CMV infection. We compared the groups for the manifestations and severity of congenial CMV disease, as well as for possible factors associated with the risk of developing CMV related infant morbidity...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28055277/matrix-metalloproteinase-multiplex-screening-identifies-increased-mmp-2-urine-concentrations-in-women-predicted-to-develop-preeclampsia
#10
M L Martinez-Fierro, A Perez-Favila, I Garza Veloz, M A Espinoza-Juarez, L Avila-Carrasco, I Delgado-Enciso, Y Ortiz-Castro, E Cardenas Vargas, M Cid-Baez, R M Ramirez-Santoyo, V H Cervantes-Kardasch, I P Rodriguez-Sanchez, J I Badillo Almaraz, R Castañeda-Miranda, L O Solis-Sanchez, J M Ortiz-Rodriguez
BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary to improve the prognosis of patients with preeclampsia. OBJECTIVE: To evaluate the usefulness of nine urinary metalloproteinases to predict the risk of preeclampsia development...
January 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28046205/dietary-advice-interventions-in-pregnancy-for-preventing-gestational-diabetes-mellitus
#11
REVIEW
Joanna Tieu, Emily Shepherd, Philippa Middleton, Caroline A Crowther
BACKGROUND: Gestational diabetes mellitus (GDM) is a form of diabetes occurring during pregnancy which can result in short- and long-term adverse outcomes for women and babies. With an increasing prevalence worldwide, there is a need to assess strategies, including dietary advice interventions, that might prevent GDM. OBJECTIVES: To assess the effects of dietary advice interventions for preventing GDM and associated adverse health outcomes for women and their babies...
January 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28044196/maternal-fasting-glycemia-and-adverse-pregnancy-outcomes-in-a-mediterranean-population
#12
G Sesmilo, E Meler, V Perea, I Rodríguez, A Rodríguez-Melcón, M Guerrero, B Serra
AIMS: The hyperglycemia and adverse pregnancy outcome study demonstrated a continuous association between fasting plasma glucose (FPG) levels below those diagnostic of diabetes and adverse neonatal outcomes. We aimed to investigate whether the same association was found in a Mediterranean population. METHODS: A retrospective analysis of singleton pregnancies attended at our Hospital between 2008 and 2015 (n = 5203). FPG was evaluated in the second trimester, and it was divided into 7 categories (1 < 75, 2 75-79, 3 80-84, 4 85-89, 5 90-94, 6 95-99 and 7 100-124 mg/dL)...
January 3, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28033561/post-pregnancy-aspirin-resistance-appears-not-to-be-related-with-recurrent-hypertensive-disorders-of-pregnancy
#13
Carolien N H Abheiden, Wessel W Fuijkschot, Arda Arduç, Jeske J K van Diemen, Ankie M Harmsze, Marjon A de Boer, Abel Thijs, Johanna I P de Vries
OBJECTIVE: The FRUIT-RCT concluded that low-molecular-weight heparin added to aspirin compared to treatment with aspirin alone is beneficial in the prevention of early-onset hypertensive disorders of pregnancy (HD) in women with inheritable thrombophilia and prior HD and/or a small-for-gestational age (SGA) infant leading to delivery before 34 weeks gestation. The aim of this study is to answer the question whether aspirin resistance is associated with recurrent HD. STUDY DESIGN: Women with and without recurrent HD matched for age, study arm, and chronic hypertension were invited for this follow-up study 6-16 years after they participated in the FRUIT-RCT...
December 21, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28032339/maternal-uniparental-disomy-of-chromosome-16-upd-16-mat-clinical-features-are-rather-caused-by-hidden-trisomy-16-mosaicism-than-by-upd-16-mat-itself
#14
Ruth Scheuvens, Matthias Begemann, Lukas Soellner, Dieter Meschede, Gisela Raabe-Meyer, Miriam Elbracht, Regine Schubert, Thomas Eggermann
Maternal uniparental disomy of chromosome 16 (upd(16)mat) as the result of trisomy 16 is one of the most frequently reported uniparental disomies in humans, but a consistent phenotype is not obvious. Particularly, it is difficult to discriminate between features resulting from upd(16)mat and mosaic trisomy 16. By evaluating literature data (n = 74) and three own cases we aimed to determine whether the clinical features are due to upd(16)mat or to trisomy 16 mosaicism. Whereas in single cases the clinical symptoms were caused by homozygosity of autosomal recessive mutations on chromosome 16, it turned out that clinical features in upd(16)mat are caused by (hidden) trisomy 16 mosaicism and a specific chromosome 16 associated imprinting disorder does not exist...
December 29, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/28012449/placental-maternal-vascular-malperfusion-and-adverse-pregnancy-outcomes-in-gestational-diabetes-mellitus
#15
Christina M Scifres, W Tony Parks, Maisa Feghali, Steve N Caritis, Janet M Catov
INTRODUCTION: Maternal vascular malperfusion (MVM) lesions represent hypoxic-ischemic damage to the placenta, and they are associated with adverse pregnancy outcomes. Women with gestational diabetes (GDM) are at increased risk for pregnancy complications, so we set out to characterize the prevalence and clinical correlates of MVM lesions in this cohort. METHODS: This was a retrospective cohort study of 1187/1374 (86.4%) women with GDM delivered between 2009 and 2012 who had placental pathology available...
January 2017: Placenta
https://www.readbyqxmd.com/read/28011814/associations-of-lipid-levels-during-gestation-with-hypertensive-disorders-of-pregnancy-and-gestational-diabetes-mellitus-a-prospective-longitudinal-cohort-study
#16
Hong Shen, Xiaohua Liu, Yan Chen, Biwei He, Weiwei Cheng
OBJECTIVE: To assess associations of elevated lipid levels during gestation with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM). METHODS: This prospective cohort study was conducted in a tertiary maternal hospital in Shanghai, China from February to November 2014. Lipid constituents, including triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) of 1310 eligible women were assessed in the first (10-13+ weeks), second (22-28 weeks) and third (30-35 weeks) trimesters consecutively...
December 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/28008305/magnesium-sulfate-prevents-placental-ischemia-induced-increases-in-brain-water-content-and-cerebrospinal-fluid-cytokines-in-pregnant-rats
#17
Linda W Zhang, Junie P Warrington
Magnesium sulfate (MgSO4) is the most widely used therapy in the clinic to prevent the progression of preeclampsia, a hypertensive disorder of pregnancy, to eclampsia. Eclampsia, manifested as unexplained seizures and/or coma during pregnancy or postpartum, accounts for ~13% of maternal deaths worldwide. While MgSO4 continues to be used in the clinic, the mechanisms by which it exerts its protective actions are not well understood. In this study, we tested the hypothesis that MgSO4 protects against placental ischemia-induced increases in brain water content and cerebrospinal fluid cytokines...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28008286/pregnancy-after-bariatric-surgery-improving-outcomes-for-mother-and-child
#18
REVIEW
Irene González, Albert Lecube, Miguel Ángel Rubio, Pedro Pablo García-Luna
The significant increase in the prevalence of obesity has led to an increase in the number of obese women who become pregnant. In this setting, in recent years, there has been an exponential rise in the number of bariatric procedures, with approximately half of them performed in women of childbearing age, and a remarkable surge in the number of women who become pregnant after having undergone bariatric surgery (BS). These procedures entail the risk of nutritional deficiencies, and nutrition is a crucial aspect during pregnancy...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27966762/case-report-low-level-trisomy-14-mosaicism-in-a-male-newborn-with-ectrodactyly
#19
M A Rodrigues, L F Morgade, L F A Dias, R V Moreira, P D Maia, A F H Sales, P D Ribeiro
Complete trisomy 14 mosaicism is a rare chromosome disorder and was first reported in 1970. We describe a case of a male neonate who presented complete trisomy 14 mosaicism in only 4% of the cells from peripheral blood. A nineteen-day-old male neonate was born as result of the second pregnancy. The infant was delivered by cesarean section due to gestational hypertension and chronic fetal distress. The length of the term pregnancy was 37 weeks, the birth weight was 3.105 g, the length was 48 cm, and the head circumference was 35...
December 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27957708/hypertension-in-pregnancy
#20
Roopa Malik, Viral Kumar
Hypertensive disorders of pregnancy remain an unresolved and unpreventable problem in obstetrics. They remain one of the leading member of deadly triad causing maternal mortality, the other two being hemorrhage and sepsis which are preventable. The incidence of hypertensive disorders worldwide is 12 %. We have discussed various terminologies used to describe hypertension during pregnancy, risk factors, etiopathogenesis, pathophysiology, management guidelines, complications and long term consequences of hypertensive disorders of pregnancy in this chapter...
December 13, 2016: Advances in Experimental Medicine and Biology
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