keyword
https://read.qxmd.com/read/38510907/effectiveness-of-ceftazidime-avibactam-in-gram-negative-nosocomial-pneumonia-a-real-world-study-in-india
#21
JOURNAL ARTICLE
Neha Gupta, Sanjith Saseedharan, Yashesh Paliwal
BACKGROUND AND OBJECTIVE: The incidences of nosocomial pneumonia in intensive care units (ICUs) in India have been reported to range from 9% to 58% and are associated with a mortality rate of 30-70%. Ceftazidime-avibactam has activity against OXA-48-like carbapenem-resistant Enterobacterales (CRE) and has a safer adverse effect profile as compared to the nephrotoxic colistin. The current study aimed to assess the effectiveness and usage pattern of ceftazidime-avibactam in gram-negative hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) in real-world settings in India...
February 2024: Curēus
https://read.qxmd.com/read/38508087/a-molecular-overview-of-the-polymyxin-lps-interaction-in-the-context-of-its-mode-of-action-and-resistance-development
#22
REVIEW
Indira Padhy, Sambit K Dwibedy, Saswat S Mohapatra
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action and the emergence of resistance to the existing drugs. Polymyxin, a cationic antimicrobial lipopeptide, is used to treat infections by Gram-negative bacterial pathogens as a last option. Though polymyxins were identified almost seventy years back, their use has been restricted owing to toxicity issues in humans. However, their clinical use has been increasing in recent times resulting in the rise of polymyxin resistance...
March 12, 2024: Microbiological Research
https://read.qxmd.com/read/38506533/outbreak-of-ndm-5-producing-klebsiella-pneumoniae-st307-an-emerging-high-risk-antimicrobial-resistance-clone-in-shanghai-china
#23
JOURNAL ARTICLE
Junying Zhu, Guangyu Wang, Min Li
The high-risk clone Klebsiella pneumoniae ST307, associated with various carbapenem resistance genes, exhibits a global distribution and prevalence. However, in China, it has remained sporadic and has rarely been detected. In this study, we reported an outbreak caused by nine ST307 CRKP isolates harboring bla NDM-5 in Shanghai, China, in 2022. We employed antimicrobial susceptibility testing, conjugation assay, whole-genome sequencing (WGS) and comparative genomics, phylogenetic analysis, and fitness and virulence comparison to further characterize the isolates causing the outbreak...
March 20, 2024: MSystems
https://read.qxmd.com/read/38506388/post-trauma-acinetobacter-baumanii-meningitis-treatment-approach
#24
Cem Erdoğan, Zeynep Betul Balcioglu, Isa Seida, Denız Kizilaslan
A. baumannii, which is said to be associated with nosocomial infections is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur in the aftermath of surgery or trauma. Our patient developed complicated A. baumannii meningitis with lateral ventriculitis and a lumbar abscess post surgery after suffering from a fall. The patient was treated with a 21-day regimen of intrathecally administered colistin and polymyxin B. Following this therapeutic period, the patient's condition improved, ultimately leading to successful recovery and subsequent discharge...
March 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
https://read.qxmd.com/read/38501368/in-vitro-activity-of-apramycin-ebl-1003-in-combination-with-colistin-meropenem-minocycline-or-sulbactam-against-xdr-pdr-acinetobacter-baumannii-isolates-from-greece
#25
JOURNAL ARTICLE
I Galani, M Souli, D Katsala, I Karaiskos, H Giamarellou, A Antoniadou
OBJECTIVES: To evaluate the in vitro activity of the combination of apramycin with colistin, meropenem, minocycline or sulbactam, against some well-characterized XDR Acinetobacter baumannii clinical isolates from Greece, to understand how apramycin can be best incorporated into clinical practice and optimize effectiveness. METHODS: In vitro interactions of apramycin (0.5×, 1× and 2× the MIC value) with colistin (2 mg/L), meropenem (30 mg/L), minocycline (3...
March 19, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38494251/emergence-of-carbapenem-resistant-gram-negative-pathogens-with-high-rate-of-colistin-resistance-in-egypt-a-cross-sectional-study-to-assess-resistance-trends-during-the-covid-19-pandemic
#26
JOURNAL ARTICLE
Fatma A Afify, Ahmed H Shata, Nirmeen Aboelnaga, Dina Osama, Salma W Elsayed, Nehal A Saif, Shaimaa F Mouftah, Sherine M Shawky, Ahmed A Mohamed, Omar Loay, Mohamed Elhadidy
The current study investigated the temporal phenotypic and genotypic antimicrobial resistance (AMR) trends among multi-drug resistant and carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa recovered from Egyptian clinical settings between 2020 and 2021. Bacterial identification and antimicrobial sensitivity of 111 clinical isolates against a panel of antibiotics were performed. Molecular screening for antibiotic resistance determinants along with integrons and associated gene cassettes was implemented...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38491938/synthesis-stereochemical-resolution-and-analogue-synthesis-of-variabiline-an-aporphine-alkaloid-that-sensitizes-acinetobacter-baumannii-and-klebsiella-pneumoniae-to-colistin
#27
JOURNAL ARTICLE
Haoting Li, Ansley M Nemeth, Roberta J Melander, Christian Melander
Increasing antimicrobial resistance, coupled with the absence of new antibiotics, has led physicians to rely on colistin, a polymyxin with known nephrotoxicity, as the antibiotic of last resort for the treatment of infections caused by Gram-negative bacteria. One approach to increasing antibiotic efficacy and thereby reducing dosage is the use of small-molecule potentiators that augment antibiotic activity. We recently identified the aporphine alkaloid (±)-variabiline, which lowers the minimum inhibitory concentration of colistin in Acinetobacter baumannii and Klebsiella pneumoniae ...
March 16, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38491859/the-combination-of-membrane-disruption-and-ftsz-targeting-by-a-chemotherapeutic-hydrogel-synergistically-combats-pathogens-infections
#28
JOURNAL ARTICLE
Xianyuan Wei, Jintong Guo, Xiaorui Geng, Bin Xue, Shaohui Huang, Zhen Yuan
The emergence of multidrug-resistant (MDR) bacteria poses a significant challenge to global health. Due to a shortage of antibiotics, alternative therapeutic strategies are urgently needed. Unfortunately, colistin, the last-resort antibiotic, has unavoidable nephrotoxicity and hepatotoxicity, and its single killing mechanism is prone to drug resistance. To address this challenge, we propose a promising combinatorial approach that includes colistin, a membrane-disrupting antimicrobial agent, and chelerythrine (CHE), a FtsZ protein inhibitor...
March 16, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38490574/establishment-and-application-of-recombinase-polymerase-amplification-combined-with-lateral-flow-dipstick-for-detection-of-mcr-1-in-unculture-clinical-samples
#29
JOURNAL ARTICLE
Jun Feng, Zhen Xu, Yuan Zhuang, Jiayuan Luo, Yong Chen, Yitong Wu, Jiayi Fei, Mingxiang Liu, Jiahui Xia, Jing Zhang, Meihua Liu, Xiaohong Xie, Zhengan Yuan, Min Chen
OBJECTIVES: The rapid dissemination of the mcr-1 gene via plasmid-mediated transfer has raised concerns regarding the efficacy of colistin as a last-resort treatment for multidrug-resistant Gram-negative bacterial infections. Current mcr-1 gene detection methods mainly focus on cultured bacterial which suffer from complexity, time-consuming process, and skilled personnel requirements, making them unsuitable for field analysis. METHODS: A rapid detection technique combining recombinase polymerase amplification (RPA) with lateral flow dipstick (LFD) targeting on uncultured clinical samples was developed...
March 13, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38489813/the-identification-of-risk-factors-and-outcomes-of-cerebrospinal-fluid-shunt-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-in-children-a-retrospective-cohort
#30
JOURNAL ARTICLE
Gizem Guner Ozenen, Zumrut Sahbudak Bal, Elif Bolat, Zuhal Umit, Nimet M Bilen, Sema Yildirim Arslan, Tuncer Turhan, Feriha Cilli, Zafer Kurugol
OBJECTIVE: Cerebrospinal fluid (CSF) shunt infections caused by gram-negative bacteria are difficult to treat given the limited treatment options and the emergence of carbapenem-resistant (CR) strains. This study aimed to evaluate the demographic and clinical characteristics of children with CSF shunt and external ventricular drain (EVD) infections caused by gram-negative bacteria, to identify the risk factors for acquiring CR CSF shunt infections, and to report on the clinical outcomes of these infections...
March 15, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38489041/sub-inhibitory-concentrations-of-colistin-and-imipenem-impact-the-expression-of-biofilm-associated-genes-in-acinetobacter-baumannii
#31
JOURNAL ARTICLE
J N Bhavya, Sureddi Sai Anugna, Ramya Premanath
Acinetobacter baumannii is an opportunistic pathogen that is responsible for nosocomial infections. Imipenem and colistin are drugs that are commonly used to treat severe infections caused by A. baumannii, such as sepsis, ventilator-associated pneumonia, and bacteremia. However, some strains of A. baumannii have become resistant to these drugs, which is a concern for public health. Biofilms produced by A. baumannii increase their resistance to antibiotics and the cells within the inner layers of biofilm are exposed to sub-inhibitory concentrations (sub-MICs) of antibiotics...
March 15, 2024: Archives of Microbiology
https://read.qxmd.com/read/38487887/regional-dissemination-of-ndm-1-producing-enterobacter-hormaechei-st1740-with-a-subset-of-strains-co-producing-vim-4-or-imp-13-france-2019-to-2022
#32
JOURNAL ARTICLE
Inès Rezzoug, Cécile Emeraud, Christophe Rodriguez, Jean-Michel Pawlotsky, Rémy A Bonnin, Laurent Dortet
BackgroundFrom 2019 to 2022, the French National Reference Centre for Antibiotic Resistance (NRC) received a total of 25 isolates of Enterobacter hormaechei subsp. hoffmannii sequence type (ST)1740. All produced metallo-β-lactamase(s) and were from the Lyon area.AimTo understand these strains' spread and evolution, more extended microbiological and molecular analyses were conducted.MethodsPatients' demographics and specimen type related to isolates were retrieved. All strains underwent short-read whole genome sequencing, and for 15, long-read sequencing to understand carbapenemase-gene acquisition...
March 2024: Euro Surveillance
https://read.qxmd.com/read/38485761/characterisation-of-colistin-resistance-in-gram-negative-microbiota-of-pregnant-women-and-neonates-in-nigeria
#33
JOURNAL ARTICLE
E A R Portal, K Sands, C Farley, I Boostrom, E Jones, M Barrell, M J Carvalho, R Milton, K Iregbu, F Modibbo, S Uwaezuoke, C Akpulu, L Audu, C Edwin, A H Yusuf, A Adeleye, A S Mukkadas, D Maduekwe, S Gambo, J Sani, T R Walsh, O B Spiller
A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing prevalence across South-East Asia. Here we survey the presence of mcr genes in 4907 rectal swabs from mothers and neonates from three hospital sites across Nigeria; a country with limited availability or history of colistin use clinically. Forty mother and seven neonatal swabs carried mcr genes in a range of bacterial species: 46 Enterobacter spp. and single isolates of; Shigella, E. coli and Klebsiella quasipneumoniae...
March 14, 2024: Nature Communications
https://read.qxmd.com/read/38484958/phenotypic-and-molecular-characterization-of-multi-drug-resistant-klebsiella-spp-isolates-recovered-from-clinical-settings
#34
JOURNAL ARTICLE
Hassan Diab, Kelven Rahy, Tamima Jisr, Mira El Chaar, Edmond Abboud, Sima Tokajian
Klebsiella pneumoniae is a Gram-negative bacterium that colonizes the gastrointestinal tract and nasopharynx with many being linked to nosocomial infections. Extended-spectrum β-lactamases (ESBL)-producing and carbapenem-resistant K. pneumoniae is recognized by the World Health Organization (WHO) as a critical public health concern. In this study, whole-genome sequencing (WGS) - based analysis was performed to understand the molecular epidemiology of multi-drug resistant Klebsiella spp. clinical isolates...
March 12, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38482272/spectrum-of-pathogens-and-their-antimicrobial-susceptibility-pattern-isolated-from-bronchoalveolar-lavage-specimens-at-a-hilly-area-in-uttarakhand
#35
JOURNAL ARTICLE
Nidhi Negi, Pankaj Rawat, Iva Chandola, Uneza Husain, Ketan Priyadarshi
BACKGROUND: Lower respiratory tract infections (LRTIs) are associated with significant morbidity and mortality in all age groups, especially young children and the elderly population. Various gram-positive and gram-negative organisms such as Streptococcus spp., Pseudomonas spp., and Klebsiella spp. have been implicated as a pathogen in bronchoalveolar lavage (BAL) specimens collected from such patients. AIMS AND RATIONALE OF THE STUDY: The present study is aimed at assessing the spectrum of the bacterial isolates and determining the antimicrobial resistance obtained from the BAL fluid from admitted patients at various wards and intensive care units (ICUs) of a tertiary care hospital in Dehradun...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38481664/molecular-epidemiology-of-multidrug-resistant-klebsiella-pneumoniae-enterobacter-cloacae-and-escherichia-coli-outbreak-among-neonates-in-tembisa-hospital-south-africa
#36
JOURNAL ARTICLE
John Osei Sekyere, Masego Mmatli, Anel Bosch, Ramathetje Virginia Ntsoane, Harishia Naidoo, Sinenhlanhla Doyisa, Nontuthuko E Maningi, Nontombi Marylucy Mbelle, Mohamed Said
BACKGROUND: An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within a tertiary hospital in South Africa resulted in the mortality of 10 patients within six months. In this work, the genomic epidemiology of and the molecular factors mediating this outbreak were investigated. METHODS: Bacterial cultures obtained from clinical samples collected from the infected neonates underwent phenotypic and molecular analyses to determine their species, sensitivity to antibiotics, production of carbapenemases, complete resistance genes profile, clonality, epidemiology, and evolutionary relationships...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38479059/molecular-epidemiology-and-mechanisms-of-carbapenem-and-colistin-resistance-in-klebsiella-and-other-enterobacterales-from-treated-wastewater-in-croatia
#37
JOURNAL ARTICLE
Ana Puljko, Ivan Barišić, Svjetlana Dekić Rozman, Stela Križanović, Ivana Babić, Marko Jelić, Ana Maravić, Nikolina Udiković-Kolić
Among the most problematic bacteria with clinical relevance are the carbapenem-resistant Enterobacterales (CRE), as there are very limited options for their treatment. Treated wastewater can be a route for the release of these bacteria into the environment and the population. The aim of this study was to isolate CRE from treated wastewater from the Zagreb wastewater treatment plant and to determine their phenotypic and genomic characteristics. A total of 200 suspected CRE were isolated, 148 of which were confirmed as Enterobacterales by MALDI-TOF MS...
March 11, 2024: Environment International
https://read.qxmd.com/read/38477004/study-of-colistin-resistant-gram-negative-organism-in-hospitalized-patients-a-retrospective-study
#38
JOURNAL ARTICLE
Dnyaneshwar Diwane, Prasad A Rajhans, Sameer A Jog, Mousami Dalvi
BACKGROUND: Intensive care units have become hotspots for antimicrobial resistance, particularly concerning colistin resistance, posing a threat of untreatable infections. AIM: This study aims to analyze the epidemiological and clinical aspects of patients carrying colistin-resistant organisms. It focuses on identifying risk factors, the microbiological profile, susceptibility patterns, and treatment outcomes. MATERIALS AND METHODS: Isolates with colistin MIC >2 µg/mL, identified via BD PHOENIX, were subjected to colistin broth disc elution testing (as per CLSI guidelines) in our Microbiology Department between January and December 2022...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38476937/mechanistic-and-biophysical-characterization-of-polymyxin-resistance-response-regulator-pmra-in-acinetobacter-baumannii
#39
JOURNAL ARTICLE
Zhenlin Ouyang, Wenbo He, Min Jiao, Qinyue Yu, Yucheng Guo, Moath Refat, Qian Qin, Jiaxin Zhang, Qindong Shi, Fang Zheng, Yurong Wen
INTRODUCTION: Acinetobacter baumannii PmrAB is a crucial two-component regulatory system (TCS) that plays a vital role in conferring resistance to polymyxin. PmrA, a response regulator belonging to the OmpR/PhoB family, is composed of a C-terminal DNA-binding effector domain and an N-terminal receiver domain. The receiver domain can be phosphorylated by PmrB, a transmembrane sensor histidine kinase that interacts with PmrA. Once phosphorylated, PmrA undergoes a conformational change, resulting in the formation of a symmetric dimer in the receiver domain...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38476757/case-report-hip-arthroplasty-after-fracture-related-joint-infection-caused-by-extensively-drug-resistant-klebsiella-pneumoniae
#40
Maximilian Fischer, Lars Nonnenmacher, Johannes C Reichert, Jürgen A Bohnert, Evgeny A Idelevich, Eyüp Doğan, Karsten Becker, Georgi I Wassilew
This case-report focuses on a 23-year-old soldier suffering from a fracture-related hip joint infection (FRI) due to extensively drug-resistant Klebsiella pneumoniae and S. epidermidis . The patient underwent multiple septic revision surgeries including the removal of remaining shrapnel accompanied by last-resort antimicrobial therapy with cefiderocol and colistin. Additionally, the surgeries included repeated tissue sampling for microbiological and histopathological analysis. An antibiotic-loaded cemented filler containing cefiderocol was used to improve local antimicrobial therapy...
2024: Frontiers in Surgery
keyword
keyword
81405
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.