keyword
MENU ▼
Read by QxMD icon Read
search

Glabridin

keyword
https://www.readbyqxmd.com/read/28804245/dna-microarray-analysis-of-estrogen-responsive-genes-in-ishikawa-cells-by-glabridin
#1
Poh Su Wei Melissa, Yong Voon Chen Phelim, Visweswaran Navaratnam, Chia Yoke Yin
Based on a previous study, glabridin displayed a dose-dependent increase in estrogenic activity and cell proliferative activity in Ishikawa cells. However, when treated in combination with 17β-E2, synergistic estrogenic effect was observed but without the same synergistic increase in cell proliferative effect. This study aimed to identify the estrogen and nonestrogen-regulated activities induced by glabridin and in combination with 17β-E2 in comparison with 17β-E2. The results showed that 10 µM glabridin and the combination treatment of 100 nM glabridin with 1 nM 17β-E2 regulated both the genomic and nongenomic estrogen pathways to possibly provide benefits of estrogens in cardiovascular, circulatory, and vasculature systems...
2017: Biochemistry Insights
https://www.readbyqxmd.com/read/28774812/cytochrome-p450-inhibition-by-three-licorice-species-and-fourteen-licorice-constituents
#2
Guannan Li, Charlotte Simmler, Luying Chen, Dejan Nikolic, Shao-Nong Chen, Guido F Pauli, Richard B van Breemen
The potential of licorice dietary supplements to interact with drug metabolism was evaluated by testing extracts of three botanically identified licorice species (Glycyrrhiza glabra L., Glycyrrhiza uralensis Fish. ex DC. and Glycyrrhiza inflata Batalin) and 14 isolated licorice compounds for inhibition of 9 cytochrome P450 enzymes using a UHPLC-MS/MS cocktail assay. G. glabra showed moderate inhibitory effects against CYP2B6, CYP2C8, CYP2C9, and CYP2C19, and weak inhibition against CYP3A4 (testosterone). In contrast, G...
July 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28763878/-glabridin-attenuates-mptp-induced-parkinson-disease-by-inhibiting-extracellular-regulated-protein-kinases-signaling-pathway
#3
Y Zhao, Z N Lu
Objective: To investigate whether Glabridin had a beneficial effect on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(MPTP) induced parkinson disease (PD) in mice, and explore the possible underlying mechanisms. Methods: Forty C57BL/6N mice were randomly assigned into control group, MPTP group, Glabridin therapy(MPTP+ GLA)group, Levodopa therapy(MPTP+ LD)group, with 10 in each group. PD model was induced by intraperitoneal administration of MPTP(20 mg/kg). The mice in MPTP+ GLA group, MPTP+ LD group and control group were gavaged by glabridin (50 mg/kg), levodopa (40 mg/kg), and equal volume of normal saline, respectively...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28707183/downregulation-of-inos-and-elevation-of-camp-mediate-the-anti-inflammatory-effect-of-glabridin-in-rats-with-ulcerative-colitis
#4
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Samar A El-Adawy
BACKGROUND: Alternative medicine is widely accepted by public and becoming an attractive approach for treatment of various diseases. Glabridin (Gla), a major flavonoid present in licorice root, was reported to have antioxidant and anti-inflammatory properties. OBJECTIVE: The study aimed to investigate the possible protective role of Gla against dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in rats and to clarify the molecular mechanisms underlying Gla function...
July 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28644019/metabolomics-analysis-to-evaluate-the-anti-inflammatory-effects-of-polyphenols-glabridin-reversed-metabolism-change-caused-by-lps-in-raw-264-7-cells
#5
Kaiqin Liu, Fuwei Pi, Hongxia Zhang, Jian Ji, Shuang Xia, Fangchao Cui, Jiadi Sun, Xiulan Sun
Inflammation has been shown to play a critical role in the development of many diseases. In this study, we used metabolomics to evaluate the inflammatory effect of lipopolysaccharide (LPS) and the anti-inflammatory effect of glabridin (GB, a polyphenol from Glycurrhiza glabra L. roots) in RAW 264.7 cells. Multivariate statistical analysis showed that in comparison with the LPS group, the metabolic profile of the GB group was more similar to that of the control group. LPS impacted the amino acid, energy, and lipid metabolisms in RAW 264...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28595940/glabridin-triggers-over-expression-of-mca1-and-nuc1-genes-in-candida-glabrata-is-it-an-apoptosis-inducer
#6
M Moazeni, M T Hedayati, M Nabili, S J Mousavi, A Abdollahi Gohar, S Gholami
The growing trends of emergence of antifungal-resistant Candida strains has recently been inspired the researchers to design new antifungal agents with novel mechanisms of action. Glabridin is an originally natural substrate with multiple biological activities which propose it as a novel anticancer, antimicrobial and antifungal agent. In the present study, the antifungal effect of glabridin against Candida glabrata isolates and its possible mechanism of action were investigated. The minimum inhibitory concentrations (MIC) for glabridin against fluconazole-resistant and fluconazole-SDD strains of C...
June 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28522265/screening-for-bioactive-natural-products-from-a-67-compound-library-of-glycyrrhiza-inflata
#7
Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye
Licorice shows a variety of pharmacological activities. This work aims to discover bioactive natural products from one botanical source of licorice, Glycyrrhiza inflata. A total of 67 free phenolics were isolated to form a compound library. Based on the bioactivities of licorice, these compounds were screened using cell- or enzyme-based bioassay methods. A total of 11 compounds exhibited potent cytotoxic activities against three human cancer cell lines (HepG2, SW480 and MCF7), while showed little toxicity on human normal cell lines LO2 and HEK293T...
May 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28464803/the-repressive-effect-of-mir-148a-on-wnt-%C3%AE-catenin-signaling-involved-in-glabridin-induced-anti-angiogenesis-in-human-breast-cancer-cells
#8
Juan Mu, Dongmei Zhu, Zhaoxia Shen, Shilong Ning, Yun Liu, Juan Chen, Yuan Li, Zhong Li
BACKGROUND: Glabridin (GLA), a major component extracted from licorice root, has anti-inflammatory and antioxidant activities, but few studies report its mechanism of inhibition of angiogenesis. This study was an extension of our previous work, which demonstrated that GLA suppressed angiogenesis in human breast cancer (MDA-MB-231 and Hs-578T) cells. Breast cancer is one of the most common malignant diseases in females worldwide, and the major cause of mortality is metastasis that is primarily attributed to angiogenesis...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28355591/effect-of-aquo-alchoholic-extract-of-glycyrrhiza-glabra-against-pseudomonas-aeruginosa-in-mice-lung-infection-model
#9
Ankita Singh Chakotiya, Ankit Tanwar, Pranay Srivastava, Alka Narula, Rakesh Kumar Sharma
The prevalence of lung infection caused by Pseudomonas aeruginosa strains that are classified as multi-drug resistant has increased considerably and is mainly attributed to relative insufficiency of potent chemotherapeutic modalities. The present study was conducted to evaluate the antimicrobial activity of aquo-alcoholic extract of Glycyrrhiza glabra against the P. aeruginosa causing lung infection in Swiss albino mice. The study involves evaluation of lethal dose of P. aeruginosa in Swiss albino mice and analysis of disease manifestation that includes bacteremia, hypothermia, reduction in body weight and other parameters for 48h of infection...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28188607/enhanced-skin-permeation-of-glabridin-using-eutectic-mixture-based-nanoemulsion
#10
Chen Liu, Jin Hu, Hong Sui, Qipeng Zhao, Xia Zhang, Wenping Wang
This study aimed to investigate the performance of the eutectic mixture of menthol and camphor (1:1, w/w) in nanoemulsion formulation for enhanced transdermal penetration of water-insoluble glabridin. Glabridin solubility in different media was determined by a shaking bottle method. The pseudoternary phase diagrams of the oil phase (drug-loaded eutectic mixture or IPM), the surfactant (Tween 80:glycerol = 2:1, w/w), and water were constructed using the aqueous titration method. The obtained glabridin nanoemulsions were characterized and compared on their particle sizes, in vitro and in vivo penetration performance on rat skin, and storage stability...
April 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28059416/macroporous-resin-purification-and-characterization-of-flavonoids-from-platycladus-orientalis-l-franco-and-their-effects-on-macrophage-inflammatory-response
#11
Jiaoyan Ren, Yamei Zheng, Zehua Lin, Xin Han, Wenzhen Liao
The flavonoids (POFs) from the leaves of Platycladus orientalis (L.) Franco were purified using six different macroporous adsorption resins including polar resins NKA-9 and ADS-F8, semi-polar resins ADS-17 and AB-8, and non-polar resins D101 and ADS-5. Among semi-polar resins, AB-8 demonstrated the best adsorption and desorption capacities with an adsorption ratio of 86% and a desorption ratio of 52%. According to the Simultaneous Thermogravimetry-Differential Scanning Calorimetry (STA/TG-DSC) analysis, POFs showed three thermally decomposed temperatures (347...
January 6, 2017: Food & Function
https://www.readbyqxmd.com/read/28057160/-glabridin-reduces-lipopolysaccharide-induced-lung-injury-in-rats-by-inhibiting-p38-mitogen-activated-protein-kinase-extracellular-regulated-protein-kinases-signaling-pathway
#12
L P Zhang, J G Li
Objective: To investigate whether glabridin has a beneficial effect on lipopolysaccharide (LPS) induced acute respiratory distress syndrome (ARDS) in rats, and to explore the possible underlying mechanisms. Methods: Thirty-two Wistar rats were randomly assigned into control group, model group (LPS group), glabridin group (GLA group), and ulinastatin group (UTI group), with 8 rats in each group. ARDS rat model was reproduced by intraperitoneal injection of LPS (10 mg/kg). The rats in the control group received an equal volume of normal saline at the same times...
December 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28039487/glabridin-attenuates-lipopolysaccharide-induced-acute-lung-injury-by-inhibiting-p38mapk-erk-signaling-pathway
#13
Li-Peng Zhang, Yan Zhao, Guo-Juan Liu, Da-Gang Yang, Yi-Huan Dong, Li-Hua Zhou
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a complication caused by pulmonary and/or external factors. In this study, we investigated the protective mechanisms of glabridin in lipopolysaccharide (LPS) induced ARDS in rats. RESULTS: GLA treatment at dose of 30 mg/kg decreased LPS-induced lung W/D ratio and alleviated evident lung histopathological changes. Expressions of TNF-α and IL-18 were suppressed by GLA in plasma. The levels of SPA, MDA and NO in lung were down-regulated significantly in groups administrated with GLA...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28038744/characterization-of-glabridin-hydroxypropyl-%C3%AE-cyclodextrin-inclusion-complex-with-robust-solubility-and-enhanced-bioactivity
#14
Yongqin Wei, Jin Zhang, Yan Zhou, Weiya Bei, Yuan Li, Qipeng Yuan, Hao Liang
Various biological activities of glabridin have been reported in literature, however, the bioavailability and clinical application was limited by its low water solubility. In this study, we developed a novel inclusion complex of glabridin and hydroxypropyl-β-cyclodextrin (HP-β-CD) that features improved solubility and bioactivity. The formation of the inclusion complex was supported by data from FT-IR, PXRD, SEM and NMR. Specifically, the NMR results indicated that the aromatic ring of glabridin was merged into and located at the narrow side the cavity of HP-β-CD...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27803449/field-survey-of-glycyrrhiza-plants-in-central-asia-4-characterization-of-g-glabra-and-g-bucharica-collected-in-tajikistan
#15
Hiroaki Hayashi, Shinya Tamura, Ren Chiba, Isao Fujii, Nobuji Yoshikawa, Inoyat Fattokhov, Madibron Saidov
The characteristics of 2 Glycyrrhiza plants, G. glabra and G. bucharica (=Meristotropis bucharica), were investigated in Tajikistan. The glycyrrhizin content in the underground parts of G. glabra varied from 2.56 to 9.29% of the dry weight, and the content of glabridin, a species-specific flavonoid of G. glabra, varied from 0.09 to 0.92% of the dry weight. Seeds of G. glabra plants from Tajikistan were cultivated for 3 years in Japan, and the glycyrrhizin content of the harvested roots ranged from 0.75 to 1...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27696846/identification-and-chemical-standardization-of-licorice-raw-materials-and-dietary-supplements-using-uhplc-ms-ms
#16
Guannan Li, Dejan Nikolic, Richard B van Breemen
Defined as the roots and underground stems of principally three Glycyrrhiza species, G. glabra L., G.uralensis Fish. ex DC. and G. inflata Batalin, licorice has been used as a medicinal herb for millennia and is marketed as root sticks, powders and extracts. Identity tests described in most pharmacopeial monographs enabled the distinction of Glycyrrhiza species. Accordingly, an ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) assay using the method of standard addition was developed to quantify 14 licorice components (liquiritin, isoliquiritin, liquiritin apioside, isoliquiritin apioside, licuraside, liquiritigenin, isoliquiritigenin, glycyrrhizin, glycyrrhetinic acid, glabridin, glycycoumarin, licoricidin, licochalcone A, and p-hydroxybenzylmalonic acid), representing several natural product classes including chalcones, flavanones, saponins, and isoflavonoids...
October 4, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27695112/efficient-percutaneous-delivery-of-the-antimelanogenic-agent-glabridin-using-cationic-amphiphilic-chitosan-micelles
#17
Haruyoshi Seino, Yukari Arai, Norio Nagao, Noriyasu Ozawa, Kazuhiko Hamada
Partially myristoylated chitosan pyrrolidone carboxylate (PMCP) is a cationic amphiphilic chitosan derivative. Glabridin (Glab) from licorice root extracts is a hydrophobic antimelanogenic agent. Here we assessed the effects of cationic Glab-containing polymeric micelles derived from PMCP (Glab/PMCP-PM) on the ability of Glab to penetrate the skin and inhibit melanogenesis using a human skin model. The amount of Glab absorbed 24 h after the application of Glab/PMCP-PM was approximately four times higher than that of conventional oil-in-water micelles (control) prepared using Tween 60...
2016: PloS One
https://www.readbyqxmd.com/read/27686831/glabridin-induced-vasorelaxation-evidence-for-a-role-of-bkca-channels-and-cyclic-gmp
#18
Debrabata Chanda, Jesus Prieto-Lloret, Arjun Singh, Hina Iqbal, Pankaj Yadav, Vladimir Snetkov, Philip I Aaronson
BACKGROUND AND PURPOSE: Glabridin is a major flavonoid in Glycyrrhiza glabra (licorice) root, a traditional Asian medicine. Glabridin is reported to have anti-atherogenic, anti-inflammatory and anti-nephritic properties; however its effects on vascular tone remain unexplored. EXPERIMENTAL APPROACH: We examined the effect of glabridin on rat main mesenteric artery using isometric myography and also ELISA to measure cGMP levels. KEY RESULTS: Glabridin (30μM) relaxed arteries pre-constricted with the thromboxane A2 analog U46619 (0...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27681719/anti-cancer-effect-of-quercetin-in-xenograft-models-with-ebv-associated-human-gastric-carcinoma
#19
Hwan Hee Lee, Seulki Lee, Yu Su Shin, Miyeon Cho, Hyojeung Kang, Hyosun Cho
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The flavonoids in licorice are known to have strong anti-cancer activities. Quercetin, the most abundant flavonoid, has been shown to have anti-ulcer, anti-cancer, antioxidant, and anti-inflammatory properties. Latent Epstein-Barr virus (EBV) infection can lead to serious malignancies, such as, Burkitt's lymphoma, Hodgkin's disease and gastric carcinoma(GC), and (Epstein-Barr virus associated gastric carcinoma) EBVaGC is one of the most common EBV-associated cancers...
September 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27539316/the-immunomodulatory-potential-of-selected-bioactive-plant-based-compounds-in-breast-cancer-a-review
#20
REVIEW
Yushau Shuaibu Baraya, Kah Keng Wong, Nik Soriani Yaacob
Breast cancer has continued to cause high cancer death rates among women worldwide. The use of plants' natural products in breast cancer treatment has received more attention in recent years due to their potentially wider safety margin and the potential to complement conventional chemotherapeutic drugs. Plantbased products have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth...
2017: Anti-cancer Agents in Medicinal Chemistry
keyword
keyword
81397
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"