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Glabridin

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https://www.readbyqxmd.com/read/27803449/field-survey-of-glycyrrhiza-plants-in-central-asia-4-characterization-of-g-glabra-and-g-bucharica-collected-in-tajikistan
#1
Hiroaki Hayashi, Shinya Tamura, Ren Chiba, Isao Fujii, Nobuji Yoshikawa, Inoyat Fattokhov, Madibron Saidov
The characteristics of 2 Glycyrrhiza plants, G. glabra and G. bucharica (=Meristotropis bucharica), were investigated in Tajikistan. The glycyrrhizin content in the underground parts of G. glabra varied from 2.56 to 9.29% of the dry weight, and the content of glabridin, a species-specific flavonoid of G. glabra, varied from 0.09 to 0.92% of the dry weight. Seeds of G. glabra plants from Tajikistan were cultivated for 3 years in Japan, and the glycyrrhizin content of the harvested roots ranged from 0.75 to 1...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27696846/identification-and-chemical-standardization-of-licorice-raw-materials-and-dietary-supplements-using-uhplc-ms-ms
#2
Guannan Li, Dejan Nikolic, Richard B van Breemen
Defined as the roots and underground stems of principally three Glycyrrhiza species, G. glabra L., G.uralensis Fish. ex DC. and G. inflata Batalin, licorice has been used as a medicinal herb for millennia and is marketed as root sticks, powders and extracts. Identity tests described in most pharmacopeial monographs enabled the distinction of Glycyrrhiza species. Accordingly, an ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) assay using the method of standard addition was developed to quantify 14 licorice components (liquiritin, isoliquiritin, liquiritin apioside, isoliquiritin apioside, licuraside, liquiritigenin, isoliquiritigenin, glycyrrhizin, glycyrrhetinic acid, glabridin, glycycoumarin, licoricidin, licochalcone A, and p-hydroxybenzylmalonic acid), representing several natural product classes including chalcones, flavanones, saponins, and isoflavonoids...
October 4, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27695112/efficient-percutaneous-delivery-of-the-antimelanogenic-agent-glabridin-using-cationic-amphiphilic-chitosan-micelles
#3
Haruyoshi Seino, Yukari Arai, Norio Nagao, Noriyasu Ozawa, Kazuhiko Hamada
Partially myristoylated chitosan pyrrolidone carboxylate (PMCP) is a cationic amphiphilic chitosan derivative. Glabridin (Glab) from licorice root extracts is a hydrophobic antimelanogenic agent. Here we assessed the effects of cationic Glab-containing polymeric micelles derived from PMCP (Glab/PMCP-PM) on the ability of Glab to penetrate the skin and inhibit melanogenesis using a human skin model. The amount of Glab absorbed 24 h after the application of Glab/PMCP-PM was approximately four times higher than that of conventional oil-in-water micelles (control) prepared using Tween 60...
2016: PloS One
https://www.readbyqxmd.com/read/27686831/glabridin-induced-vasorelaxation-evidence-for-a-role-of-bkca-channels-and-cyclic-gmp
#4
Debrabata Chanda, Jesus Prieto-Lloret, Arjun Singh, Hina Iqbal, Pankaj Yadav, Vladimir Snetkov, Philip I Aaronson
BACKGROUND AND PURPOSE: Glabridin is a major flavonoid in Glycyrrhiza glabra (licorice) root, a traditional Asian medicine. Glabridin is reported to have anti-atherogenic, anti-inflammatory and anti-nephritic properties; however its effects on vascular tone remain unexplored. EXPERIMENTAL APPROACH: We examined the effect of glabridin on rat main mesenteric artery using isometric myography and also ELISA to measure cGMP levels. KEY RESULTS: Glabridin (30μM) relaxed arteries pre-constricted with the thromboxane A2 analog U46619 (0...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27681719/anti-cancer-effect-of-quercetin-in-xenograft-models-with-ebv-associated-human-gastric-carcinoma
#5
Hwan Hee Lee, Seulki Lee, Yu Su Shin, Miyeon Cho, Hyojeung Kang, Hyosun Cho
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The flavonoids in licorice are known to have strong anti-cancer activities. Quercetin, the most abundant flavonoid, has been shown to have anti-ulcer, anti-cancer, antioxidant, and anti-inflammatory properties. Latent Epstein-Barr virus (EBV) infection can lead to serious malignancies, such as, Burkitt's lymphoma, Hodgkin's disease and gastric carcinoma(GC), and (Epstein-Barr virus associated gastric carcinoma) EBVaGC is one of the most common EBV-associated cancers...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27539316/the-immunomodulatory-potential-of-selected-bioactive-plant-based-compounds-in-breast-cancer-a-review
#6
Yusha U Shu Aibu Baraya, Kah Keng Wong, Nik Soriani Yaacob
Breast cancer has continued to cause high cancer death rates among women worldwide. The use of plants' natural products in breast cancer treatment has received more attention in recent years due to their potentially wider safety margin and the potential to complement conventional chemotherapeutic drugs. Plant-based products have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth...
August 17, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27516832/punicalagin-induces-serum-low-density-lipoprotein-influx-to-macrophages
#7
Dana Atrahimovich, Soliman Khatib, Shifra Sela, Jacob Vaya, Abraham O Samson
High levels of circulating low-density lipoprotein (LDL) are a primary initiating event in the development of atherosclerosis. Recently, the antiatherogenic effect of polyphenols has been shown to be exerted via a mechanism unrelated to their antioxidant capacity and to stem from their interaction with specific intracellular or plasma proteins. In this study, we investigated the interaction of the main polyphenol in pomegranate, punicalagin, with apolipoprotein B-100 (ApoB100) that surrounds LDL. Punicalagin bound to ApoB100 at low concentrations (0...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27466044/antimutagenic-components-in-glycyrrhiza-against-n-methyl-n-nitrosourea-in-the-ames-assay
#8
Keiko Inami, Yusuke Mine, Yukiko Kojo, Satomi Tanaka, Satoko Ishikawa, Masataka Mochizuki
Antimutagenesis against N-nitroso compounds contribute to prevention of human cancer. We have found that Glycyrrhiza aspera ethanolic extract exhibits antimutagenic activity against N-methyl-N-nitrosourea (MNU) using the Ames assay with Salmonella typhimurium TA1535. In the present study, eight purified components from Glycyrrhiza, namely glabridin, glycyrrhetinic acid, glycyrrhizin, licochalcone A, licoricesaponin H2, licoricesaponin G2, liquiritigenin and liquiritin were evaluated for their antimutagenicity against MNU in the Ames assay with S...
July 28, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27434879/glabridin-and-glycyrrhizic-acid-show-no-beneficial-effect-on-the-chemical-composition-and-mechanical-properties-of-bones-in-ovariectomized-rats-when-administered-in-moderate-dose
#9
Ilona Kaczmarczyk-Sedlak, Sylwia Klasik-Ciszewska, Weronika Wojnar
BACKGROUND: One of the major causes of osteoporosis and bone fracture in postmenopausal women is estrogen deficiency. To prevent the fractures, and avoid the side effects of hormone replacement therapy, phytoestrogens including the isoflavonoids are used. In the presented study two constituents occurring in the licorice root-the isoflavane glabridin and triterpenoid saponin glycyrrhizic acid were examined on the skeletal system of ovariectomized rats. METHODS: The female Wistar rats were divided into five groups: control group, ovariectomized group as well as three ovariectomized groups treated with estradiol (0...
October 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27348968/glabridin-nanosuspension-for-enhanced-skin-penetration-formulation-optimization-in-vitro-and-in-vivo-evaluation
#10
COMPARATIVE STUDY
W P Wang, J Hul, H Sui, Y S Zhao, J Feng, C Liu
Glabridin, a polyphenolic flavonoid from licorice, has inspired great interest for its antioxidant, anti-inflammatory and skin-lightening activities. However, low water solubility and poor stability of glabridin impedes its topical application in cosmetic products and therapies of dermal diseases. The purpose of this study was to develop a nanosuspension formulation of glabridin to improve its skin permeation. Glabridin nanosuspensions were prepared using anti-solvent precipitation-homogenization method, and Box-Behnken design was adopted to investigate the effects of crucial formulation variables on particle size and to optimize the nanosuspension formulation...
May 2016: Die Pharmazie
https://www.readbyqxmd.com/read/27181267/simultaneous-deactivation-of-fak-and-src-improves-the-pathology-of-hypertrophic-scar
#11
Linlin Su, Xiaodong Li, Xue Wu, Bo Hui, Shichao Han, Jianxin Gao, Yan Li, Jihong Shi, Huayu Zhu, Bin Zhao, Dahai Hu
Hypertrophic scar (HS) is a serious fibrotic skin condition with currently no satisfactory therapy due to undefined molecular mechanism. FAK and Src are two important non-receptor tyrosine kinases that have been indicated in HS pathogenesis. Here we found both FAK and Src were activated in HS vs. normal skin (NS), NS fibroblasts treated with TGF-β1 also exhibited FAK/Src activation. Co-immunoprecipitation and dual-labelled immunofluorescence revealed an enhanced FAK-Src association and co-localization in HS vs...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27180445/effect-of-glabridin-and-glycyrrhizic-acid-on-histomorphometric-parameters-of-bones-in-ovariectomized-rats
#12
COMPARATIVE STUDY
Sylwia Klasik-Ciszewska, Ilona Kaczmarczyk-Sedlak, Weronika Wojnar
Licorice is a medicinal plant showing many therapeutic activities. Its roots contain numerous pharmacologically active compounds such as a triterpenoid saponin--glycyrrhizic acid and an isoflavan--glabridin. There are reports indicating that glabridin exhibits estrogen-like activity, therefore it can be classified into phytoestrogens, which may soothe menopause symptoms including postmenopausal osteoporosis. Due to this fact, the aim of the presented study was to evaluate the effect of glabridin and glycyrrhizic acid on histomorphometric parameters of bones in rats with ovariectomy-induced osteoporosis...
March 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/27103104/development-and-validation-of-hplc-and-hptlc-methods-for-estimation-of-glabridin-in-extracts-of-glycyrrhiza-glabra
#13
Vivek Viswanathan, Alka P Mukne
Glabridin is a major bioactive phytoconstituent of licorice. This work discusses the development and validation of HPLC and HPTLC methods for analysis of glabridin in licorice. The HPLC separation was performed using a Purospher STAR RP-18e column (5 μm silica particle size, 250 mm × 4.6 mm inner diameter) with gradient elution of 0.2% acetic acid in water-acetonitrile. The flow rate was 1 mL/min. Quantification was performed at a detection wavelength of 280 nm. HTPLC separation was performed on precoated silica gel 60 F254 aluminum plate (10 × 10 cm, 250 μm thickness)...
March 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27002406/glabridin-induces-apoptosis-and-autophagy-through-jnk1-2-pathway-in-human-hepatoma-cells
#14
Ming-Ju Hsieh, Mu-Kuan Chen, Chih-Jung Chen, Ming-Chang Hsieh, Yu-Sheng Lo, Yi-Ching Chuang, Hui-Ling Chiou, Shun-Fa Yang
BACKGROUND: Extensive research results support the use of herbal medicine or natural food to augment therapy for various cancers. Studies have associated glabridin with numerous biological activities, such as regulating energy metabolism and estrogenic, neuroprotective, antiosteoporotic, and skin-whitening activities. HYPOTHESIS/PURPOSE: However, how glabridin affects tumor cell autophagy has not been clearly determined. METHODS: Autophagy is a lysosomal degradation pathway essential for cell survival and tissue homeostasis...
April 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26795272/antitumoral-antioxidant-and-antimelanogenesis-potencies-of-hawthorn-a-potential-natural-agent-in-the-treatment-of-melanoma
#15
Nadia Mustapha, Imèn Mokdad-Bzéouich, Mouna Maatouk, Kamel Ghedira, Thierry Hennebelle, Leila Chekir-Ghedira
The lack of an efficient agent that does not have the disadvantage of low activity (kojic acid), high cytotoxicity, and mutagenicity (hydroquinone), poor skin penetration (arbutin), or low stability in formulation (glabridin) led us to continue our research on new antipigmentation/skin-lightening agents. Therefore, research of natural products that can modulate the metabolism of pigmentation is of great interest. Otherwise, malignant melanoma is one of the most aggressive forms of skin cancer, with high metastatic potential, and currently, there is no effective chemotherapy against invasive melanoma...
June 2016: Melanoma Research
https://www.readbyqxmd.com/read/26631549/licorice-root-components-in-dietary-supplements-are-selective-estrogen-receptor-modulators-with-a-spectrum-of-estrogenic-and-anti-estrogenic-activities
#16
Nittaya Boonmuen, Ping Gong, Zulfiqar Ali, Amar G Chittiboyina, Ikhlas Khan, Daniel R Doerge, William G Helferich, Kathryn E Carlson, Teresa Martin, Pawinee Piyachaturawat, John A Katzenellenbogen, Benita S Katzenellenbogen
Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extracts also contain a number of other flavonoids, isoflavonoids, and chalcones. We have investigated the estrogenic activity of 7 of these components, obtained from an extract of Glycyrrhiza glabra powder, namely Glabridin (L1), Calycosin (L2), Methoxychalcone (L3), Vestitol (L4), Glyasperin C (L5), Glycycoumarin (L6), and Glicoricone (L7), and compared them with Liq, Iso-Liq, and estradiol (E2)...
January 2016: Steroids
https://www.readbyqxmd.com/read/26586395/glabridin-arrests-cell-cycle-and-inhibits-proliferation-of-hepatocellular-carcinoma-by-suppressing-braf-mek-signaling-pathway
#17
Ziyou Wang, Shengqun Luo, Zheng Wan, Chuyan Chen, Xiangning Zhang, Binbin Li, GuoLiang Huang, Liyong Chen, Zhiwei He, Zunnan Huang
Glabridin, an isoflavone isolated from licorice, owns a variety of pharmacological effects. Several reports have demonstrated that glabridin could regulate multiple cellular signaling pathways to inhibit the progression of cancer. However, the target proteins have not been elucidated yet. We used shape screening and induced fit docking to screen the protein data bank against glabridin. Braf and MEK1/2, important intermediate molecules of the braf/MEK cascade, were identified as the potential targets of glabridin...
May 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26537652/-determination-of-the-plant-origin-of-licorice-oil-extract-a-natural-food-additive-by-principal-component-analysis-based-on-chemical-components
#18
Atsuko Tada, Kyoko Ishizuki, Naoki Sugimoto, Kayo Yoshimatsu, Nobuo Kawahara, Takako Suematsu, Kazunori Arifuku, Toshio Fukai, Yukiyoshi Tamura, Takashi Ohtsuki, Maiko Tahara, Takeshi Yamazaki, Hiroshi Akiyama
"Licorice oil extract" (LOE) (antioxidant agent) is described in the notice of Japanese food additive regulations as a material obtained from the roots and/or rhizomes of Glycyrrhiza uralensis, G. inflata or G. glabra. In this study, we aimed to identify the original Glycyrrhiza species of eight food additive products using LC/MS. Glabridin, a characteristic compound in G. glabra, was specifically detected in seven products, and licochalcone A, a characteristic compound in G. inflata, was detected in one product...
2015: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/26526087/cardiovascular-protective-effect-of-glabridin-implications-in-ldl-oxidation-and-inflammation
#19
REVIEW
Moo Rim Kang, Ki Hwan Park, Soo Jin Oh, Jieun Yun, Chang Woo Lee, Myeong Youl Lee, Sang-Bae Han, Jong Soon Kang
Atherosclerosis is one of the most common causes of death in Western countries and now considered as a chronic inflammatory disease in broad outline. Glaridin, a flavonoid isolated from licorice root, has been shown to exert a variety of biological activities, including antimicrobial, antioxidant, anti-inflammatory and cardiovascular protective effects. Among these, the most extensive research area in the past two decades was a cardiovascular protection-related activity of glabridin. The protective effect of glabridin on LDL oxidation, which is one of the important processes involved in the development of atherosclerosis, was demonstrated in vitro and in vivo and the mechanisms involved in this process were established well...
December 2015: International Immunopharmacology
https://www.readbyqxmd.com/read/26455358/glabridin-an-isoflavan-from-licorice-root-upregulates-paraoxonase-2-expression-under-hyperglycemia-and-protects-it-from-oxidation
#20
Itamar Yehuda, Zecharia Madar, Alicia Leikin-Frenkel, Andrea Szuchman-Sapir, Faiga Magzal, Gilad Markman, Snait Tamir
SCOPE: Hyperglycemia is associated with oxidative stress, which accelerates cardiovascular complications. This study investigates the potential of glabridin to regulate paraoxonase 2 (PON2) levels, in vivo, and explores the glabridin protective effect on PON2 through tryptophan-fluorescence quenching and mass spectrometry. METHODS AND RESULTS: Adult mouse offspring of saturated fatty acids fed mothers, which developed hyperglycemia after exposure to a high fat diet in their adult life, had lower levels of heart PON2 mRNA and protein expression than did the control mice (64 and 26%, respectively)...
February 2016: Molecular Nutrition & Food Research
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