keyword
https://read.qxmd.com/read/38497297/effect-of-glabridin-combined-with-bakuchiol-on-uvb-induced-skin-damage-and-its-underlying-mechanism-an-experimental-study
#1
JOURNAL ARTICLE
Guanjie Peng, Yangsi Li, Yiyan Zeng, Bowen Sun, Lanyue Zhang, Qingqing Liu
BACKGROUND: Research has demonstrated the anti-photoaging properties of glabridin and bakuchiol. METHODS: The impact of glabridin, glabridin + bakuchiol, and bakuchiol on the levels of tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) in mice skin fibroblasts was observed. Furthermore, we investigated the potential roles of fibronectin (FN), interferon-γ (IFN-γ), interleukin-22 (IL-22), and transforming growth factor-β (TGF-β) in the tissues, and evaluated their impact on the enzymatic levels in the skin...
March 18, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38440026/in-silico-analysis-of-selected-glycyrrhiza-glabra-licorice-constituents-exploring-their-modulatory-effects-on-human-superoxide-dismutase-human-phosphodiesterase-9-and-human-dipeptidyl-peptidase-4
#2
JOURNAL ARTICLE
Naveena Tamilarasu, Radhakrishnan Narayanaswamy, Vasantha-Srinivasan Prabhakaran
Background Glycyrrhiza glabra (Licorice) has been known for its various biological activities. In the current investigation, we aimed to evaluate 11 (10 natural and one synthetic) selected constituents of G. glabra as potent modulatory agents of human superoxide dismutase (hSOD), human phosphodiesterase-9 (hPDE 9) and human dipeptidyl peptidase-4 (hDPP 4) using in silico method. Methodology The 11 selected constituents of G. glabra (Licorice) were investigated on the docking behaviour of hSOD, hPDE 9 and hDPP 4 by using the PatchDock method...
February 2024: Curēus
https://read.qxmd.com/read/38372849/glabridin-reduces-neuroinflammation-by-modulating-inflammatory-signals-in-lps-induced-in-vitro-and-in-vivo-models
#3
JOURNAL ARTICLE
Jiyu Weng, Ying Wang, Zekai Tan, Yanghe Yuan, Shiyuan Huang, Zexi Li, Yiming Li, Lanyue Zhang, Zhiyun Du
OBJECTIVES: Chronic neuroinflammation has become one of the important causes of common neurodegeneration disease. Therefore, the target of this study was to explore the protective action of glabridin on lipopolysaccharide (LPS)-induced neuroinflammation in vivo and in vitro and its mechanism. METHODS: The neuroinflammation model was established by LPS-induced BV2 cells. The cell viability with various concentrations of glabridin was determined by MTT assay, and the content of NO in each group was detected...
February 19, 2024: Inflammopharmacology
https://read.qxmd.com/read/38346287/the-therapeutic-role-and-mechanism-of-glabridin-under-aspergillus-fumigatus-infection
#4
JOURNAL ARTICLE
Lu Zhan, Xue Tian, Jing Lin, Yingxue Zhang, Guiqiu Zhao, Xudong Peng
Purpose: To characterize the efficiency of glabridin alone and in combination with clinical antifungals in Aspergillus fumigatus keratitis. Methods: The broth microdilution method was performed to investigate whether glabridin exerted an antifungal role on planktonic cells and immature and mature biofilm. Antifungal mechanism was evaluated by Sorbitol and Ergosterol Assays. The synergistic effect of glabridin and antifungals was assessed through the checkerboard microdilution method and time-killing test. Regarding anti-inflammatory role, inflammatory substances induced by A...
2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38316223/integration-of-network-pharmacology-with-experimental-validation-to-reveal-the-mechanism-of-action-of-longdan-xiegan-decoction-against-hsv2-infection-and-determine-its-effective-components
#5
JOURNAL ARTICLE
Yuyun Li, Siyan Li, Zeren Shou, Yibin Li, Axin Li, Wenli Liu, Xin Zhang, Chengliang Zhou, Daohua Xu, Lin Li
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese Medicine (TCM) has made enormous strides recently in the discovery of anti-herpes simplex virus (HSV) drugs under the guidance of TCM theory. Longdan Xiegan Decoction (LXD), a formulation recorded in the Pharmacopoeia of the People's Republic of China, has proved to be effective against HSV infection. However, its effective components and action mechanism remain unclear. AIM OF THE STUDY: To investigate the effective components and mechanisms of LXD in treating HSV infection based on network pharmacology and experimental validation...
February 3, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38267702/prenylated-flavonoid-fractions-from-glycyrrhiza-glabra-alleviate-insulin-resistance-in-hepg2-cells-by-regulating-the-erk-irs-1-and-pi3k-akt-signaling-pathways
#6
JOURNAL ARTICLE
Defeng Li, Jinling Fan, Lin Du, Guoyan Ren
Insulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown significant hypoglycemic activity, its bioactive components remain to be identified, and their mechanisms of action, especially on hepatocyte glucose metabolism, are yet to be explored. In the present study, the primary compounds from Glycyrrhiza glabra [named prenylated flavonoid fractions (PFFs)] have been identified and their chemical structures have been elucidated...
January 24, 2024: Archives of Pharmacal Research
https://read.qxmd.com/read/38128979/effects-of-the-antimicrobial-glabridin-on-membrane-integrity-and-stress-response-activation-in-listeria-monocytogenes
#7
JOURNAL ARTICLE
Alberto Bombelli, Carla Araya-Cloutier, Sjef Boeren, Jean-Paul Vincken, Tjakko Abee, Heidy M W den Besten
Glabridin is a prenylated isoflavan which can be extracted from liquorice roots and has shown antimicrobial activity against foodborne pathogens and spoilage microorganisms. However, its application may be hindered due to limited information about its mode of action. In this study, we aimed to investigate the mode of action of glabridin using a combined phenotypic and proteomic approach on Listeria monocytogenes. Fluorescence and transmission electron microscopy of cells exposed to glabridin showed membrane permeabilization upon treatment with lethal concentrations of glabridin...
January 2024: Food Research International
https://read.qxmd.com/read/38086658/switching-the-polarity-of-mouse-enteroids-affects-the-epithelial-interplay-with-prenylated-phenolics-from-licorice-glycyrrhiza-roots
#8
JOURNAL ARTICLE
Sarah van Dinteren, Carla Araya-Cloutier, Edyta Robaczewska, Mellody den Otter, Renger Witkamp, Jean-Paul Vincken, Jocelijn Meijerink
The utility of 3D-small intestinal organoid (enteroid) models for evaluating effects of e.g. food (related) compounds is limited due to the apical epithelium facing the interior. To overcome this limitation, we developed a novel 3D-apical-out enteroid model for mice, which allows apical exposure. Using this model, we evaluated the effects on the enteroids' intestinal epithelium (including cytotoxicity, cell viability, and biotransformation) after exposure to glabridin, a prenylated secondary metabolite with antimicrobial properties from licorice roots ( Glycyrrhiza glabra )...
December 12, 2023: Food & Function
https://read.qxmd.com/read/38066431/glabridin-improves-autoimmune-disease-in-trex1-deficient-mice-by-reducing-type-i-interferon-production
#9
JOURNAL ARTICLE
Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu, Zhaofang Bai
BACKGROUND: The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING signaling pathway, a natural immune pathway mediated by the nucleic acid receptor cGAS, and the development and progression of autoimmune diseases. Therefore, it is important to identify an effective compound to specifically downregulate this pathway for disease. METHODS: The effect of Glabridin (Glab) was investigated in BMDMs and Peripheral blood mononuclear cell (PBMC) by establishing an in vitro model of cGAS-STING signaling pathway activation...
December 8, 2023: Molecular Medicine
https://read.qxmd.com/read/37986059/tracking-the-effect-of-roasting-and-fermentation-on-the-metabolites-of-licorice-root-glycyrrhiza-glabra-l-using-uplc-ms-analysis-combined-with-multivariate-statistical-analysis
#10
JOURNAL ARTICLE
Sarah S Takla, Eman Shawky, Yasmin A Mahgoub, Reham S Darwish
BACKGROUND: Roasting, honey-roasting and fermentation are the most common pre-processing procedures of licorice roots. They were shown to noticeably change the composition of extracts. In this work, the common alterations in licorice secondary metabolites by processing were interpreted. Comprehensive metabolic profiling of different studied samples was undergone. METHODS: UPLC-QqQ-MS/MS analysis coupled to various chemometric analysis models was implemented to unravel the effect of different pre-processing procedures on the chemical profile of licorice samples...
November 20, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37984749/natural-isoflavone-glabridin-targets-pi3k%C3%AE-as-an-adjuvant-to-increase-the-sensitivity-of-mda-mb-231-to-tamoxifen-and-du145-to-paclitaxel
#11
JOURNAL ARTICLE
Hongyan Lin, Dongxuan Ai, Qingqing Liu, Xinling Wang, Qingqing Chen, Zhongbin Hong, Yuheng Tao, Jian Gao, Liqun Wang
Glabridin is a natural isoflavone with estrogen receptor agonism and significant anti-tumor activity. Additionally, glabridin has a regulation effect on PI3K/AKT/mTOR pathway, but its exact target remains unclear. In this study, we evaluated the antitumor activity of glabridin against breast cancer and prostate cancer cells, and further clarified its targeting to PI3K. We found that glabridin could significantly inhibit the cell viability of human breast cancer and prostate cancer cell lines. It induced caspase activation cascade and cell apoptosis through decreasing the mitochondrial transmembrane potential and increasing the intracellular reactive oxygen species (ROS)...
November 18, 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/37958031/the-power-of-licorice-radix-glycyrrhizae-to-improve-oral-health-a-comprehensive-review-of-its-pharmacological-properties-and-clinical-implications
#12
REVIEW
Hebah AlDehlawi, Ahoud Jazzar
Licorice ( Radix glycyrrhizae ) is a plant root extract widely used in various applications, including cosmetics, food supplements, and traditional medicine. It has a long history of medicinal use in different cultures due to its diverse pharmacological properties. Licorice has traditionally been used for treating gastrointestinal problems, respiratory infections, cough, bronchitis, arthritis, and skin conditions. In recent years, the potential therapeutic benefits of licorice for oral health have gained significant interest...
November 2, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37925093/revisiting-licorice-as-a-functional-food-in-the-management-of-neurological-disorders-bench-to-trend
#13
REVIEW
Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharma
Traditional and scientific evidence attribute numerous bioactivities of Licorice (Glycyrrhiza glabra Linn.) in aging-related disorders. In this state-of-art review, an extensive search in several databases was conducted to collect all relevant literature and comprehensively analyze Licorice's pharmacological attributes, neuroprotective properties, safety, and its mechanistic role in treating various neurological conditions. Network pharmacology was employed for the first time exploring the mechanistic role of Licorice in neurological disorders...
November 2, 2023: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/37876433/mechanistic-inhibition-of-gastric-cancer-associated-bacteria-helicobacter-pylori-by-selected-phytocompounds-a-new-cutting-edge-computational-approach
#14
JOURNAL ARTICLE
Shopnil Akash, Imren Bayıl, Sajjat Mahmood, Nobendu Mukerjee, Tamanna Akter Mili, Kuldeep Dhama, Md Anisur Rahman, Swastika Maitra, Mohamed Mohany, Salim S Al-Rejaie, Nemat Ali, Prabhakar Semwal, Rohit Sharma
BACKGROUND: Helicobacter pylori ( H. pylori ) is a persistent bacterial inhabitant in the stomachs of approximately half the global populace. This bacterium is directly linked to chronic gastritis, leading to a heightened risk of duodenal and gastric ulcer diseases, and is the predominant risk factor for gastric cancer - the second most common cause of cancer-related deaths globally. The increasing prevalence of antibiotic resistance necessitates the exploration of innovative treatment alternatives to mitigate the H...
October 2023: Heliyon
https://read.qxmd.com/read/37820716/local-delivery-of-glabridin-by-biomolecular-microneedle-to-accelerate-infected-wound-healing
#15
JOURNAL ARTICLE
Zesheng Chen, Tao Hu, Rui Wang, Bohan Huang, Lingfeng Tu, Guanyi Wang, Cao Li, Binghai Dong, Zijian Wang, Weikang Hu
Applying antibacterial polymers and pro-regenerative small molecules are two individual strategies for accelerating wound healing. However, integrating those two unique approaches into one therapeutic platform that meets clinical requirements is still a challenge. Herein, a series of antibacterial gelatin methacrylate (GelMA)/ε-polylysine (ε-PL) composite hydrogels (termed as GP-n HGs, n = 0, 10, 20 and 30, respectively) were innovatively fabricated by ultraviolet light (UV) crosslinking. The GP-n HGs were proved to be broad-spectrum antibacterial and biocompatible...
October 11, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37714449/glabridin-ameliorates-intracellular-events-caused-by-palmitic-acid-and-alcohol-in-mouse-hepatocytes-and-fast-food-diet-and-alcohol-induced-steatohepatitis-and-fibrosis-in-c57bl-6j-mice-model
#16
JOURNAL ARTICLE
Raghu Rai Sharma, Haroon Rashid, Aalim Maqsood Bhat, Archoo Sajida, Ragni Gupta, Sheikh Tasduq Abdullah
Steatohepatitis is a significant risk factor for end-stage liver disease. In this study, the therapeutic potential of Glabridin (GBD), an isoflavan derived from Glycyrrhiza glabra, is investigated in in-vitro and in-vivo models against palmitic acid (PA) or fast food (FF) diet + alcohol (EtOH). Mouse hepatocytes (AML-12 cells) were treated with PA; 250μM + EtOH; 250μM ± GBD (10μM and 25μM) for 24 hours. C57BL/6J mice fed with standard chow (SC) diet, fast food (FF) diet + intermittent oral ingestion of EtOH (10-50%v/v) ± GBD (20mg/kg and 40mg/kg) for eight (8) weeks, were analyzed for histological features of steatohepatitis and fibrosis, biochemical indexes, and protein and gene expression studies related to oxidative stress, inflammation, lipogenesis, fibrosis, and apoptosis...
September 13, 2023: Food and Chemical Toxicology
https://read.qxmd.com/read/37711984/development-and-optimization-of-culture-medium-for-the-production-of-glabridin-by-aspergillus-eucalypticola-an-endophytic-fungus-isolated-from-glycyrrhiza-glabra-l-fabaceae
#17
JOURNAL ARTICLE
Parisa Bahadori Ganjabadi, Mohsen Farzaneh, Mohammad Hossein Mirjalili
Glabridin is a well-known active isoflavone found in the root of licorice ( Glycyrrhiza glabra L.) that possess a wide range of biological activity. Plant cells, hairy roots, and fungal endophytes cultures are the most important alternative methods for plant resources conservation and sustainable production of natural compounds, which has received much attention in recent decades. In the present study, an efficient culture condition was optimized for the biomass accumulation and glabridin production from fungal endophyte Aspergillus eucalypticola SBU-11AE isolated from licorice root...
2023: Mycobiology
https://read.qxmd.com/read/37693914/effect-of-anti-obesity-agent-hsg4112-on-overweight-and-obese-patients-following-12-weeks-of-oral-treatment-a-study-protocol-for-a-randomised-double-blind-placebo-controlled-parallel-group-phase-2a-clinical-trial
#18
JOURNAL ARTICLE
Kyungha Min, Bumjo Oh, Hye Yeon Koo, Yang-Hyun Kim, Ji-Won Lee, Sangsub Lee, Youngah Kim, Hyuktae Kwon
BACKGROUND: Glaceum Inc. has proposed HSG4112, a structural analogue of glabridin, as a novel anti-obesity compound. Animal studies and phase I human trials have shown that HSG4112 improves energy consumption, normalises weight, and is safe and drug-resistant. Based on these results, the company plans to conduct a phase 2a clinical trial to determine the safety and efficacy of HSG4112 in overweight and obese patients. METHODS: A 16-week randomised, double-blind, placebo-controlled, parallel-group trial will be conducted at five large hospitals in South Korea to assess the safety and efficacy of HSG4112 in overweight and obese patients...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37667809/glabridin-functions-as-a-quorum-sensing-inhibitor-to-inhibit-biofilm-formation-and-swarming-motility-of-multidrug-resistant-acinetobacter-baumannii
#19
JOURNAL ARTICLE
Hang Lin, Cui Zhou, Kai-Hang Yu, Yi-Shuai Lin, Ling-Bo Wang, Ying Zhang, Shi-Xing Liu, Wen-Ya Xu, Yao Sun, Tie-Li Zhou, Jian-Ming Cao, Jian-Zhong Ye
OBJECTIVE: Acinetobacter baumannii is a hazardous bacterium that causes hospital-acquired nosocomial infections, and the advent of multidrug-resistant A. baumannii (MDR-AB) strains is concerning. Novel antibacterial therapeutic strategies must be developed. The biological effects of glabridin on MDR-AB were investigated in this study. METHODS: The minimum inhibitory concentrations (MICs) of glabridin against eight clinical MDR-AB strains were determined using the broth microdilution technique...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37584465/immunomodulatory-effect-of-glabridin-in-ovalbumin-induced-allergic-asthma-and-its-comparison-with-methylprednisolone-in-a-preclinical-rodent-model
#20
JOURNAL ARTICLE
Hafsa Muhammad, Zari Salahuddin, Tasleem Akhtar, Usman Aftab, Ali Rafi, Safdar Hussain, Muhammad Shahzad
Glabridin, a polyphenolic flavonoid derived from Glycyrrhiza glabra (licorice) roots, has shown anti-inflammatory and antioxidant properties. The current study sought to investigate glabridin's immunomodulatory effect in ovalbumin induced allergic asthma. Healthy male Wistar rats were divided into five groups. Group I served as a control group. Asthma was induced in groups II- IV. Groups III and IV were treated with glabridin (40 mg/kg) and methylprednisolone (15 mg/kg), respectively. Inflammatory cells counts were determined in blood and bronchoalveolar lavage fluid (BALF)...
August 16, 2023: Journal of Cellular Biochemistry
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