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https://www.readbyqxmd.com/read/29779316/-the-necessity-of-artificial-kidney-seeper-in-the-ultrasonography-guided-percutaneous-nephrolithotomy-a-randomized-controlled-study
#1
J J Ye, Y Yang, H J Zhang, Y C Zheng, Y Pan, H Xie
Objective: To investigate the necessity of artificial kidney seeper which made through inserting a ureteral tube in the ureter to the ultrasonography-guided percutaneous nephrolithotomy (PCNL). Methods: This was a randomized prospective study. Patients who conformed to the inclusion and exclusion criteria were enrolled at Department of Urology, Frist Affiliated Hospital of Wenzhou Medical University from January 2016 to May 2017. Totally 291 patients were included in the study. Patients were randomly assigned into two groups (artificial kidney seeper group and non-artificial kidney seeper group) in different kidney seeper level (5 to <10 mm, 10 to 20 mm) respectively...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29775503/artificial-rod-and-cone-photoreceptors-with-human-like-spectral-sensitivities
#2
Byeongho Park, Heehong Yang, Tai Hwan Ha, Hyun Seo Park, Seung Ja Oh, Yong-Sang Ryu, Youngho Cho, Hyo-Suk Kim, Juyeong Oh, Dong Kyu Lee, Chulki Kim, Taikjin Lee, Minah Seo, Jaebin Choi, Young Min Jhon, Deok Ha Woo, Seok Lee, Seok Hwan Kim, Hyuk-Jae Lee, Seong Chan Jun, Hyun Seok Song, Tai Hyun Park, Jae Hun Kim
Photosensitive materials contain biologically engineered elements and are constructed using delicate techniques, with special attention devoted to efficiency, stability, and biocompatibility. However, to date, no photosensitive material has been developed to replace damaged visual-systems to detect light and transmit the signal to a neuron in the human body. In the current study, artificial nanovesicle-based photosensitive materials are observed to possess the characteristics of photoreceptors similar to the human eye...
May 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29744412/biodegradation-behavior-of-magnesium-and-zk60-alloy-in-artificial-urine-and-rat-models
#3
Shiying Zhang, Yanze Bi, Jianye Li, Zhenguo Wang, Jingmin Yan, Jiawang Song, Haibo Sheng, Heqing Guo, Yan Li
In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy were investigated as new temporary implants for urinary applications. The corrosion mechanism in artificial urine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarization tests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively, and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm-2 , respectively. The in vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0...
June 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29730503/fibulin-7-a-heparin-binding-matricellular-protein-promotes-renal-tubular-calcification-in-mice
#4
Jun Tsunezumi, Hidekazu Sugiura, Lalhaba Oinam, Aktar Ali, Bui Quoc Thang, Aiko Sada, Yoshito Yamashiro, Makoto Kuro-O, Hiromi Yanagisawa
Ectopic calcification occurs during development of chronic kidney disease and has a negative impact on long-term prognosis. The precise molecular mechanism and prevention strategies, however, are not established. Fibulin-7 (Fbln7) is a matricellular protein structurally similar to elastogenic short fibulins, shown to bind dental mesenchymal cells and heparin. Here, we report that Fbln7 is highly expressed in renal tubular epithelium in the adult kidney and mediates renal calcification in mice. In vitro analysis revealed that Fbln7 bound heparin at the N-terminal coiled-coil domain...
May 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29725630/glomerular-disease-in-women
#5
REVIEW
Kate Wiles, Liz Lightstone
Gender differences exist in the prevalence of glomerular diseases. Data based on histological diagnosis underestimate the prevalence of preeclampsia, which is almost certainly the commonest glomerular disease in the world, and uniquely gender-specific. Glomerular disease affects fertility via disease activity, the therapeutic use of cyclophosphamide, and underlying chronic kidney disease. Techniques to preserve fertility during chemotherapy and risk minimization of artificial reproductive techniques are considered...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29696094/aquaporin-graphene-interface-relevance-to-point-of-care-device-for-renal-cell-carcinoma-and-desalination
#6
REVIEW
Jakub Jakowiecki, Agnieszka Sztyler, Slawomir Filipek, Pingzuo Li, Karthik Raman, Natarajan Barathiraja, Seeram Ramakrishna, Jairam R Eswara, Ali Altaee, Adel O Sharif, Pulickel M Ajayan, Venkatesan Renugopalakrishnan
The aquaporin superfamily of hydrophobic integral membrane proteins constitutes water channels essential to the movement of water across the cell membrane, maintaining homeostatic equilibrium. During the passage of water between the extracellular and intracellular sides of the cell, aquaporins act as ultra-sensitive filters. Owing to their hydrophobic nature, aquaporins self-assemble in phospholipids. If a proper choice of lipids is made then the aquaporin biomimetic membrane can be used in the design of an artificial kidney...
June 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29673324/gabriel-richet-when-medicine-combines-with-courage
#7
EDITORIAL
Pierre Ronco
Gabriel Richet, one of the fathers of the French and international Nephrology, was a man remarkable for his courage, vision and empathy. He was proud and brave, and he presented himself proud of being brave. He opens his interview speaking about his youth, when he was injured, and went back to the fight. He cites the number of stitches he received, but doesn't cite being decorated with the Légion d'Honneur, one of the highest honours of the French Republic. This anecdote perfectly illustrates his elegance and detachment from awards and self-satisfaction...
April 19, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29611340/the-targeted-anti-oxidant-mitoq-causes-mitochondrial-swelling-and-depolarization-in-kidney-tissue
#8
Esther M Gottwald, Michael Duss, Milica Bugarski, Dominik Haenni, Claus D Schuh, Ehud M Landau, Andrew M Hall
Kidney proximal tubules (PTs) contain a high density of mitochondria, which are required to generate ATP to power solute transport. Mitochondrial dysfunction is implicated in the pathogenesis of numerous kidney diseases. Damaged mitochondria are thought to produce excess reactive oxygen species (ROS), which can lead to oxidative stress and activation of cell death pathways. MitoQ is a mitochondrial targeted anti-oxidant that has shown promise in preclinical models of renal diseases. However, recent studies in nonkidney cells have suggested that MitoQ might also have adverse effects...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29597221/technical-complications-of-continuous-renal-replacement-therapy
#9
Zaccaria Ricci, Stefano Romagnoli
Continuous renal replacement therapy (CRRT) is commonly applied in critically ill patients affected by severe acute kidney injury for solute and volume control and to optimize acid-base and electrolytes balance. Although CRRT represents a life-saving procedure for these patients, it is a representation of a non-physiologic artificial kidney and the potential benefits of the treatment could be hampered by clinical and technical side effects. Different parts of the CRRT system can be a source of technical complications...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29596866/preliminary-report-on-stone-breakage-and-lesion-size-produced-by-a-new-extracorporeal-electrohydraulic-sparker-array-discharge-device
#10
Bret A Connors, Ray B Schaefer, John J Gallagher, Cynthia D Johnson, Guangyan Li, Rajash K Handa, Andrew P Evan
OBJECTIVE: To determine if an innovative extracorporeal electrohydraulic shock wave device (sparker array) can effectively fracture artificial stones in vitro and in vivo, and if sparker array treatment produces a renal lesion in our pig model of lithotripsy injury. Results of these experiments will be used to help evaluate the suitability of this device as a clinical lithotripter. METHODS: Utracal-30 artificial stones were placed in a holder at the focus of the sparker array and treated with 600 shock waves (21...
March 26, 2018: Urology
https://www.readbyqxmd.com/read/29595122/population-pharmacokinetics-and-pharmacodynamics-of-fondaparinux-in-japanese-patients-after-artificial-total-knee-replacement
#11
Kazuhiko Hanada, Soichi Shibata, Yuki Takashima, Takuma Matsuo, Keisuke Iwa, Hajime Matsubara, Yasunori Tsukimura, Harumi Takahashi
OBJECTIVE: This study was designed to clarify the factors affecting the efficacy, adverse events, and pharmacokinetics of fondaparinux in Japanese patients undergoing artificial knee replacement surgery. MATERIALS AND METHODS: Fondaparinux (1.5 mg/d) was administered subcutaneously to patients (n = 30) at 24 hours after surgery, and blood samples were taken at various time points thereafter. Venous thromboembolism (VTE), presence of bleeding, and pharmacokinetics were evaluated...
March 29, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29594137/artificial-intelligence-for-the-artificial-kidney-pointers-to-the-future-of-a-personalized-hemodialysis-therapy
#12
REVIEW
Miguel Hueso, Alfredo Vellido, Nuria Montero, Carlo Barbieri, Rosa Ramos, Manuel Angoso, Josep Maria Cruzado, Anders Jonsson
Background: Current dialysis devices are not able to react when unexpected changes occur during dialysis treatment or to learn about experience for therapy personalization. Furthermore, great efforts are dedicated to develop miniaturized artificial kidneys to achieve a continuous and personalized dialysis therapy, in order to improve the patient's quality of life. These innovative dialysis devices will require a real-time monitoring of equipment alarms, dialysis parameters, and patient-related data to ensure patient safety and to allow instantaneous changes of the dialysis prescription for the assessment of their adequacy...
February 2018: Kidney Diseases
https://www.readbyqxmd.com/read/29577222/-establishment-of-comprehensive-prediction-model-of-acute-gastrointestinal-injury-classification-of-critically-ill-patients
#13
Yan Wang, Jianrong Wang, Weiwei Liu, Guangliang Zhang
OBJECTIVE: To develop the comprehensive prediction model of acute gastrointestinal injury (AGI) grades of critically ill patients. METHODS: From April 2015 to November 2015, the binary channel gastrointestinal sounds (GIS) monitor system which has been developed and verified by the research group was used to gather and analyze the GIS of 60 consecutive critically ill patients who were admitted in Critical Care Medicine of Chinese PLA General Hospital. Also, the AGI grades (Grande I(-IIII(, the higher the level, the heavier the gastrointestinal dysfunction) were evaluated...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29562206/semipermeable-membranes-and-hypernatremic-dehydration-in-preterms-a-randomized-controlled-trial
#14
Valentina Cardiello, Enrico Zecca, Mirta Corsello, Teresa Pianini, Francesca Serrao, Simonetta Costa, Francesco Cota
BACKGROUND: Hypernatremic dehydration is a complication of preterm infants with reportedly high morbility. In preterm infants, this happens due to a combination of low fluid intake, transepidermal water loss (TEWL), and immaturity of kidney function. Semipermeable membranes are self-adhesive membranes that can be applied as an artificial skin to reduce TEWL. AIMS: To test the hypothesis that early application of a semipermeable membrane (Tegaderm™) in preterm infants ≤30 weeks could result in a significant reduction of hypernatremia (serum Na > 145 mEq/l) during the first 15 days of life...
April 2018: Early Human Development
https://www.readbyqxmd.com/read/29549001/expression-of-recombinant-human-lysozyme-in-bacterial-artificial-chromosome-transgenic-mice-promotes-the-growth-of-bifidobacterium-and-inhibits-the-growth-of-salmonella-in-the-intestine
#15
Lu Dan, Shen Liu, Shengzhe Shang, Huihua Zhang, Ran Zhang, Ning Li
Targeted gene modification is a novel intervention strategy to increase disease resistance more quickly than traditional animal breeding. Human lysozyme, a natural, non-specific immune factor, participates in innate immunity, exerts a wide range of antimicrobial activities against pathogens, and has immuneregulatory effects. Therefore, it is a candidate gene for improved disease resistance in animals. In this study, we successfully generated a transgenic mouse model by microinjecting a modified bacterial artificial chromosome containing a recombinant human lysozyme (rhLZ) gene into the pronuclei of fertilized mouse embryos...
April 20, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29523820/zfp226-is-a-novel-artificial-transcription-factor-for-selective-activation-of-tumor-suppressor-kibra
#16
Katrin Schelleckes, Boris Schmitz, Malte Lenders, Mirja Mewes, Stefan-Martin Brand, Eva Brand
KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design an artificial transcription factor capable of re-activating expression of the tumor suppressor KIBRA and the hippo pathway. We engineered a new gene named 'ZFP226' encoding for a ~23 kDa fusion protein...
March 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29519278/-effect-of-early-intervention-with-heparin-on-function-of-coagulopathy-liver-and-kidney-in-rats-with-exertional-heatstroke-under-the-ambient-air-of-high-temperature-and-low-humidity
#17
Yang Yu, Yuying Wei, Xiangrong Zhang, Xinyu Li
OBJECTIVE: To explore the effects of early intervention with heparin on function of coagulopathy, liver and kidney as well as the prognosis in rats with exertional heatstroke (EHS) under the ambient air of high temperature and low humidity. METHODS: 108 healthy SPF male Sprague-Dawley (SD) rats were randomly divided into normal temperature control group, EHS + normal saline (NS) group and EHS + heparin group. Of which 54 rats were collected for survival analysis (18 rats in each group), the weight change and 8-hour survival rate were observed, and Kaplan-Meier survival curves were drawn...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29518558/leucaena-leucocephala-pod-seed-protein-as-an-alternate-to-animal-protein-in-fish-feed-and-evaluation-of-its-role-to-fight-against-infection-caused-by-vibrio-harveyi-and-pseudomonas-aeruginosa
#18
Vipin Kumar Verma, Kumari Vandana Rani, Shiva Raj Kumar, Om Prakash
The laboratory acclimatized Clarias gariepinus (80 ± 10 g) were divided into six groups and five subgroups each containing 10 fish. A fish feed was reconstituted by adding 33% powder of Leucaena leucocephala seed in place of fish trash. Group B, C and E were fed on reconstituted feed and group A, D and F were fed on artificial feed containing animal protein for 7 days prior to start of experiments. Then Group B was challenged with BSA while other groups were challenged with Vibrio harveyi (Group C, D) and Pseudomonas aeruginosa (Group E, F)...
May 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29517917/nanoscale-electrochemical-sensing-and-processing-in-microreactors
#19
Mathieu Odijk, Albert van den Berg
In this review, we summarize recent advances in nanoscale electrochemistry, including the use of nanoparticles, carbon nanomaterials, and nanowires. Exciting developments are reported for nanoscale redox cycling devices, which can chemically amplify signal readout. We also discuss promising high-frequency techniques such as nanocapacitive CMOS sensor arrays or heterodyning. In addition, we review electrochemical microreactors for use in (drug) synthesis, biocatalysis, water treatment, or to electrochemically degrade urea for use in a portable artificial kidney...
March 8, 2018: Annual Review of Analytical Chemistry
https://www.readbyqxmd.com/read/29482907/does-fluid-type-and-amount-affect-kidney-function-in-critical-illness
#20
REVIEW
Neil J Glassford, Rinaldo Bellomo
Acute kidney injury (AKI) is common, although commonly used clinical diagnostic markers are imperfect. Intravenous fluid administration remains a cornerstone of therapy worldwide, but there is minimal evidence of efficacy for the use of fluid bolus therapy outside of specific circumstances, and emerging evidence associates fluid accumulation with worse renal outcomes and even increased mortality among critically ill patients. Artificial colloid solutions have been associated with harm, and chloride-rich solutions may adversely affect renal function...
April 2018: Critical Care Clinics
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