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https://www.readbyqxmd.com/read/28522333/development-of-qsars-for-parameterizing-physiology-based-toxicokinetic-models
#1
Dimosthenis Α Sarigiannis, Krystalia Papadaki, Periklis Kontoroupis, Spyros P Karakitsios
A Quantitative Structure Activity Relationship (QSAR) model was developed in order to predict physicochemical and biochemical properties of industrial chemicals of various groups. This model was based on the solvation equation, originally proposed by Abraham. In this work Abraham's solvation model got parameterized using artificial intelligence techniques such as artificial neural networks (ANNs) for the prediction of partitioning into kidney, heart, adipose, liver, muscle, brain and lung for the estimation of the bodyweight-normalized maximal metabolic velocity (Vmax) and the Michaelis - Menten constant (Km)...
May 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28509945/ant-mediated-indirect-negative-effects-of-aphids-on-spider-mites-living-on-the-same-plant
#2
Masaaki Adachi, Shuichi Yano
Some aphid species are known to have mutualistic relationships with tending ants; that is, the aphids supply the ants with honeydew and are protected by the ants. Although spider mites and honeydew-producing aphids often live on the same host plant, it has not previously been determined whether the ants tending these aphids affect spider mite survival. Using replicated microcosms, each containing an artificial ant nest, we compared experimentally the survival of two-spotted spider mites on kidney bean plants with and without cowpea aphids...
May 16, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28469243/reconstitution-of-ovarian-function-following-transplantation-of-primordial-germ-cells
#3
Ming Zeng, Xiaoyan Sheng, David L Keefe, Lin Liu
Ovarian aging occurs earlier than somatic aging. We tested the hypothesis that ovarian functions could be artificially reconstructed by transplantation of primordial germ cells (PGCs). We compared various methods for transplantation of PGCs aggregated with gonadal somatic cells and showed that reconstituted ovaries exhibited folliculogenesis after transplantation of PGCs-aggregates into either kidney capsule or ovarian bursa. Neo-oogenesis occurred early after transplantation, as evidenced by the presence of prophase I meiocytes displaying homologous pairing...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28466293/-renal-replacement-therapy-in-acute-kidney-injury
#4
REVIEW
S J Klein, M Joannidis
Acute kidney injury is still a common complication in intensive care units and is associated with a significantly increased risk for morbidity and mortality. Various treatment concepts, like continuous renal replacement therapy (RRT) or (modified) intermittent procedures, as well as different methods of anticoagulation and the general decision of when and if to initiate RRT have to be considered by the treating physician. While giving vital input on when to initiate RRT, the German ELAIN (Early versus late initiation of renal replacement therapy in critically ill patients) trial and the French AKIKI (The artificial kidney initiation in kidney injury) trial raised many more questions...
May 2, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28457645/toxicological-and-thermoregulatory-effects-of-feather-contamination-with-artificially-weathered-mc-252-oil-in-western-sandpipers-calidris-mauri
#5
Ivan Maggini, Lisa V Kennedy, Steven J Bursian, Karen M Dean, Alexander R Gerson, Kendal E Harr, Jane E Link, Chris A Pritsos, Karen L Pritsos, Christopher G Guglielmo
The external contamination of bird feathers with crude oil might have effects on feather structure and thus on thermoregulation. We tested the thermoregulatory ability of western sandpipers (Calidris mauri) in a respirometry chamber with oil applied either immediately prior, or three days before the experiment. The birds were then exposed to a sliding cold temperature challenge between 27°C and -3°C to calculate thermal conductance. After the experiment, a large blood sample was taken and the liver extracted to measure a range of parameters linked to toxicology and oxidative stress...
April 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28449660/selective-measurement-of-%C3%AE-smooth-muscle-actin-why-%C3%AE-actin-can-not-be-used-as-a-housekeeping-gene-when-tissue-fibrosis-occurs
#6
Apor Veres-Székely, Domonkos Pap, Erna Sziksz, Eszter Jávorszky, Réka Rokonay, Rita Lippai, Kálmán Tory, Andrea Fekete, Tivadar Tulassay, Attila J Szabó, Ádám Vannay
BACKGROUND: Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increased expression of α smooth muscle actin (α-SMA) that belongs to the family of the six conserved actin isoforms showing high degree homology. The aim of the present study was to develop real-time PCRs that clearly discriminate α-SMA and ß-actin from other actin isoforms...
April 27, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28447929/five-year-follow-up-on-transplanted-organs-from-donors-after-brain-death-after-acute-stroke
#7
Vera Spatenkova, Eva Pokorna, Petr Suchomel
OBJECTIVES: Efficient intensive care donor management can help alleviate the shortage of organs for transplant. The aim of this study was to investigate the efficiency of management of donors after brain death from our neurointensive care unit. MATERIALS AND METHODS: We conducted a prospective observational 5-year follow-up on 29 transplanted organs from 14 brain-dead donors after acute stroke (7 subarachnoid and 4 intracerebral hemorrhages, 3 ischemic strokes)...
April 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28434235/recirculation-zone-length-in-renal-artery-is-affected-by-flow-spirality-and-renal-to-aorta-flow-ratio
#8
Ashkan Javadzadegan, David Fulker, Tracie Barber
Haemodynamic perturbations such as flow recirculation zones play a key role in progression and development of renal artery stenosis, which typically originate at the aorta-renal bifurcation. The spiral nature of aortic blood flow, division of aortic blood flow in renal artery as well as the exercise conditions have been shown to alter the haemodynamics in both positive and negative ways. This study focuses on the combinative effects of spiral component of blood flow, renal-to-aorta flow ratio and the exercise conditions on the size and distribution of recirculation zones in renal branches using computational fluid dynamics technique...
April 24, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28388934/isolation-and-identification-of-a-new-strain-of-hirame-rhabdovirus-hirrv-from-japanese-flounder-paralichthys-olivaceus-in-china
#9
Jialin Zhang, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
BACKGROUND: Hirame rhabdovirus virus (HIRRV) is a rhabdovirus that causes acute hemorrhage disease in fish culture, resulting in a great economic loss in parts of Asia and Europe. METHODS: In this study, we isolated a virus strain named as CNPo2015 from cultured Japanese flounder in Shandong province, China. Cell isolation, electron microscopic observation, RT-PCR detection and phylogenetic analysis were used for virus identification. Further, artificial infection experiment was conducted for virulence testing...
April 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28385037/new-for-old-coagulum-lithotomy-vs-a-novel-bioadhesive-for-complete-removal-of-stone-fragments-in-a-comparative-study-in-an-ex-vivo-porcine-model
#10
Dominik Stefan Schoeb, Martin Schoenthaler, Daniel Schlager, Ralf Petzold, Katharina Richter, Ingo Grunwald, Ulrich Wetterauer, Arkadiusz Miernik, Simon Hein
OBJECTIVES: To evaluate a recently reported new bioadhesive system for the retrieval of small residual fragments (RFs) after intracorporeal lithotripsy, we systematically compared this system with coagulum lithotomy in retrograde intrarenal surgery. MATERIALS AND METHODS: We extracted 30 human stone fragments (≤1 mm) in an ex vivo porcine kidney model using a flexible ureteroscope for three groups: (1) the novel bioadhesive, (2) autologous blood as a natural adhesive, and (3) (control group) a conventional retrieval basket...
May 8, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28383772/aberrant-expression-of-mico1-and-mico1os-in-deceased-somatic-cell-nuclear-transfer-calves
#11
Guan-Nan Wang, Wen-Zhi Yang, Da Xu, Dong-Jie Li, Cui Zhang, Wei-Na Chen, Shi-Jie Li
Incomplete reprogramming of a donor nucleus following somatic cell nuclear transfer (SCNT) results in aberrant expression of developmentally important genes, and is the primary source of the phenotypic abnormalities observed in cloned animals. Expression of non-coding RNAs in the murine Dlk1-Dio3 imprinted domain was previously shown to correlate with the pluripotency of mouse induced pluripotent stem cells. In this study, we examined the transcription of the bovine orthologs from this locus, MICO1 (Maternal intergenic circadian oscillating 1) and MICO1OS (MICO1 opposite strand), in tissues from artificially inseminated and SCNT calves that died during the perinatal period...
April 6, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28381092/in-vitro-comparison-of-maximum-pressure-developed-by-irrigation-systems-in-a-kidney-model
#12
Silvia Proietti, Laurian Dragos, Bhaskar K Somani, Salvatore Butticè, Michele Talso, Esteban Emiliani, Mohammed Baghdadi, Guido Giusti, Olivier Traxer
PURPOSE: To evaluate in vitro the maximum pressure generated in an artificial kidney model when people of different levels of strengths used various irrigation systems. MATERIALS AND METHODS: Fifteen people were enrolled and divided in 3 groups based on their strengths. Individual strength was evaluated according to the maximum pressure each participant was able to achieve using an Encore™ Inflator. The irrigation systems evaluated were: T-FlowTM Dual Port, HilineTM, continuous flow single action pumping system (SAPSTM) with the system close and open, Irri-flo IITM, a simple 60-ml syringe and PeditrolTM ...
April 5, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28363058/investigation-of-the-presence-of-atoxoplasma-spp-in-blue-crowned-laughingthrush-dryonastes-courtoisi-adults-and-neonates
#13
Florence Mohr, Martha Betson, Benoit Quintard
Between 1996 and 2013, 71 blue-crowned laughingthrush (Dryonastes courtoisi) chicks, a small passerine bird endemic to China, were born at Mulhouse Zoo in northeast France. None of them survived past 1 yr, and 82% died between 0 and 6 days old of an unidentified cause and despite an attempt to establish an artificial breeding protocol. Atoxoplasma spp., causing a disease known as systemic isosporosis, is a coccidian parasite that can infect several species of birds. Mulhouse's adult birds were suspected to be infected with Atoxoplasma spp...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28361319/making-a-kidney-organoid-using-the-directed-differentiation-of-human-pluripotent-stem-cells
#14
Minoru Takasato, Melissa H Little
An organoid can be defined as a three-dimensional organ-like structure formed from organ-specific progenitor cells. Organ progenitor cells were empirically found to self-organize three-dimensional tissues when they were aggregated and cultivated in vitro. While this nature power of progenitor cells has an amazing potential to recreate artificial organs in vitro, there had been difficulty to apply this technology to human organs due to the inaccessibility to human progenitor cells until human-induced pluripotent stem cell (hiPSC) was invented by Takahashi and Yamanaka in 2007...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28349871/development-of-methods-for-avian-oil-toxicity-studies-using-the-double-crested-cormorant-phalacrocorax-auritus
#15
Fred Cunningham, Karen Dean, Katie Hanson-Dorr, Kendal Harr, Kate Healy, Katherine Horak, Jane Link, Susan Shriner, Steven Bursian, Brian Dorr
Oral and external dosing methods replicating field exposure were developed using the double crested cormorant (DCCO) to test the toxicity of artificially weathered Deepwater Horizon Mississippi Canyon 252 oil. The majority of previous oil dosing studies conducted on wild-caught birds used gavage methods to dose birds with oil and determine toxicity. However, rapid gut transit time of gavaged oil likely reduces oil absorption. In the present studies, dosing relied on injection of oil into live feeder fish for oral dosing of these piscivorous birds, or applying oil to body contour feathers resulting in transdermal oil exposure and oral exposure through preening...
March 24, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28343953/development-and-validation-of-a-novel-and-cost-effective-animal-tissue-model-for-training-transurethral-resection-of-the-prostate
#16
Sichuan Hou, Gillian Ross, Iain Tait, Paul Halliday, Benjie Tang
OBJECTIVES: To develop and validate a new and cost-effective animal tissue training model for practicing resection skills of transurethral resection of the prostate (TURP). METHODS AND MATERIALS: A porcine kidney was prepared and restructured to simulate the relevant anatomy of the human prostate. The restructured prostate was connected to an artificial urethra and bladder. Face, content, and construct validity of the model was carried out using a 5-point Likert scale questionnaire, and comparison in task performance between participants and experts was made using observational clinical human reliability analysis...
March 23, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28342847/na-k-atpase-interaction-with-methylglyoxal-as-reactive-metabolic-side-product
#17
Marika Svrckova, Martina Zatloukalova, Petra Dvorakova, Dominika Coufalova, David Novak, Lenka Hernychova, Jan Vacek
Proteins are subject to oxidative modification and the formation of adducts with a broad spectrum of reactive species via enzymatic and non-enzymatic mechanisms. Here we report that in vitro non-enzymatic methylglyoxal (MGO) binding causes the inhibition and formation of MGO advanced glycation end-products (MAGEs) in Na(+)/K(+)-ATPase (NKA). Concretely, MGO adducts with NKA amino acid residues (mainly Arg) and N(ε)-(carboxymethyl)lysine (CML) formation were found. MGO is not only an inhibitor for solubilized NKA (IC50=91±16μM), but also for reconstituted NKA in the lipid bilayer environment, which was clearly demonstrated using a DPPC/DPPE liposome model in the presence or absence of the NKA-selective inhibitor ouabain...
March 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28322169/potential-therapeutic-strategies-of-regenerative-medicine-for-renal-failure
#18
Monica Maribel Mata-Miranda, Raul Jacobo Delgado-Macuil, Marlon Rojas-Lopez, Ricardo Martinez-Flores, Gustavo Jesus Vazquez-Zapien
Kidney diseases are a public health problem worldwide; the mortality rate is between 50 and 80%. Available therapies include replacement function by dialysis or transplant, associated with a high morbidity and mortality; kidney transplantation is limited by the shortage of donor organs, immune rejection and lifelong treatment with immunosuppressive. Likewise, none of these treatments compensates all kidney functions. There is a great concern in developing more effective therapies with the ability to replace the wide range of renal functions, so that, new researches on developing therapeutic strategies have focused on regenerative medicine, science that includes artificial creation of tissues and organs, in order to repair or replace a tissue or organ function...
March 17, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28290973/total-artificial-heart-implantation-as-a-bridge-to-heart-transplantation-in-an-active-duty-service-member-with-amyloid-cardiomyopathy
#19
Michael S Scully, Dylan E Wessman, James M McKee, Gregory M Francisco, Keshav R Nayak, Jon A Kobashigawa
INTRODUCTION: Cardiac involvement by light-chain (AL) amyloid occurs in up to 50% of patients with primary AL amyloidosis. The prognosis of amyloid heart disease is poor with 1-year survival rates of 35 to 40%. Historically, heart transplantation was considered controversial for patients with AL amyloid cardiomyopathy (CM) given the systemic nature of the disease and poor survival. We present a case report of an active duty service member diagnosed with advanced cardiac amyloid who underwent total artificial heart transplant as a bridge to heart transplant and eventual autologous stem cell transplant...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28268708/evaluation-of-biofouling-for-implantable-micro-dialysis-system
#20
T Ota, N To, Y Kanno, N Miki
Implantable artificial kidney can drastically improve the quality of life of the renal disease patients. In previous study, our group has developed a multi-layered micro dialysis device which is composed of micro stainless steel channels and nano-porous polyethersulfone (PES) membranes. The device conducts hemofiltration without dialysis fluids, which is advantageous in miniaturization. We investigated the water-permeability of the PES membrane through in vivo experiments using rat model of renal disease for 5 hours and verified the effectiveness of the device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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