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https://www.readbyqxmd.com/read/28226896/evaluation-of-biofouling-for-implantable-micro-dialysis-system
#1
T Ota, N To, Y Kanno, N Miki, T Ota, N To, Y Kanno, N Miki, T Ota, Y Kanno, N Miki, N To
Implantable artificial kidney can drastically improve the quality of life of the renal disease patients. In previous study, our group has developed a multi-layered micro dialysis device which is composed of micro stainless steel channels and nano-porous polyethersulfone (PES) membranes. The device conducts hemofiltration without dialysis fluids, which is advantageous in miniaturization. We investigated the water-permeability of the PES membrane through in vivo experiments using rat model of renal disease for 5 hours and verified the effectiveness of the device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219431/assessment-of-triglyceride-and-cholesterol-in-overweight-people-based-on-multiple-linear-regression-and-artificial-intelligence-model
#2
Jing Ma, Jiong Yu, Guangshu Hao, Dan Wang, Yanni Sun, Jianxin Lu, Hongcui Cao, Feiyan Lin
BACKGROUND: The prevalence of high hyperlipemia is increasing around the world. Our aims are to analyze the relationship of triglyceride (TG) and cholesterol (TC) with indexes of liver function and kidney function, and to develop a prediction model of TG, TC in overweight people. METHODS: A total of 302 adult healthy subjects and 273 overweight subjects were enrolled in this study. The levels of fasting indexes of TG (fs-TG), TC (fs-TC), blood glucose, liver function, and kidney function were measured and analyzed by correlation analysis and multiple linear regression (MRL)...
February 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28217897/captopril-apparently-increase-and-cisplatin-apparently-decrease-human-albumin-concentration-in-artificial-urinary-solutions
#3
Rafał Kuzioła, Barbara Marczewska, Krzysztof Marczewski
BACKGROUND: Measurement of urinary albumin (HSA) is very important in diagnostic of kidney diseases. Much less is known about the possible impact of substances present in urine together with albumin on the results of measurements. METHODS: We investigated the effect of the presence of captopril and cisplatin in the solution on the result of the determination of HSA by native polyacrylamide gel electrophoresis. Protein conformation in the absence and presence of the drugs was examined using Fourier Transform Infrared Spectroscopy (FTIR)...
February 20, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28210225/increased-apoptosis-in-the-paraventricular-nucleus-mediated-by-at1r-ras-erk1-2-signaling-results-in-sympathetic-hyperactivity-and-renovascular-hypertension-in-rats-after-kidney-injury
#4
Hongguo Zhu, Lishan Tan, Yumin Li, Jiawen Li, Minzi Qiu, Lanying Li, Mengbi Zhang, Min Liang, Aiqing Li
Background: The central nervous system plays a vital role in the development of hypertension, but the molecular regulatory mechanisms are not fully understood. This study aimed to explore signaling in the paraventricular nucleus (PVN) which might contribute to renal hypertension. Methods: Renal hypertension model was established by five-sixth nephrectomy operation (5/6Nx) in male Sprague Dawley rats. Ten weeks afterwards, they were random assigned to no treatment, or intracerebroventricular injection (ICV) with artificial cerebrospinal fluid, losartan [angiotensin II receptor type 1 (AT1R) antagonist], farnesylthiosalicylic acid (Ras inhibitor), PD98059 (MEK inhibitor), or SB203580 (p38 inhibitor) and Z-DEVD-FMK (caspase-3 inhibitor)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28197024/nanotechnology-in-urology
#5
REVIEW
Sudhindra Jayasimha
INTRODUCTION: Nanotechnology has revolutionized our approach to medical diagnostics as well as therapeutics and has spanned an entirely new branch of research. This review addresses the potential applications of Nanotechnology in Urology. This article is based on the Dr. Sitharaman Best Essay award of the Urological Society of India for 2016. METHODS: A PubMed search was performed for all relevant articles using the terms, "nanotechnology, nanoparticles, nanoshells, nanoscaffolds, and nanofibers...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28105119/clinical-observation-on-the-treatment-of-acute-liver-failure-by-combined-non-biological-artificial-liver
#6
Maoqin Li, Jingxi Sun, Jiaqiong Li, Zaixiang Shi, Jiyuan Xu, Bo Lu, Shuli Cheng, Yanjun Xu, Xiaomeng Wang, Xianjiang Zhang
The clinical efficacy and safety of different combinations of non-bio artificial liver in the treatment of acute liver failure was examined. A total of 61 cases were selected under blood purification treatment from the patients with severe acute liver failure admitted to the severe disease department of the hospital from December, 2010 to December, 2015. Three types of artificial liver combinations were observed, i.e., plasma exchange plus hemoperfusion plus continuous venovenous hemodiafiltration (PE+HP+CVVHDF), PE+CVVHDF and HP+CVVHDF...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28074528/respiratory-motion-prediction-and-prospective-correction-for-free-breathing-arterial-spin-labeled-perfusion-mri-of-the-kidneys
#7
Hao Song, Dan Ruan, Wenyang Liu, V Andrew Stenger, Rolf Pohmann, Maria A Fernandez Seara, Tejas Nair, Sungkyu Jung, Jingqin Luo, Yuichi Motai, Jingfei Ma, John D Hazle, H Michael Gach
PURPOSE: Respiratory motion prediction using an artificial neural network (ANN) was integrated with pseudocontinuous arterial spin labeling (pCASL) MRI to allow free-breathing perfusion measurements in the kidney. In this study, we evaluated the performance of the ANN to accurately predict the location of the kidneys during image acquisition. METHODS: A pencil-beam navigator was integrated with a pCASL sequence to measure lung/diaphragm motion during ANN training and the pCASL transit delay...
January 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28039937/quantitative-evaluation-of-the-effects-of-urinary-stone-composition-and-size-on-color-doppler-twinkling-artifact-a-phantom-study
#8
Mengmeng Shang, Xiao Sun, Qing Liu, Jie Li, Dandan Shi, Song Ning, Lin Cheng
OBJECTIVES: The present study was conducted to quantitatively evaluate the influence of urinary stone composition and size on color Doppler twinkling artifact. METHODS: Calcium oxalate monohydrate (COM), apatite, L-cystine, and uric acid (UA) stone phantoms with 10 different sizes were prepared artificially and embedded in the renal sinus of porcine kidneys in vitro. Color Doppler ultrasound scanning was performed on the phantoms and TA pictures were recorded. The length of the twinkling artifact (TAL) and width of twinkling artifact (TAW) were measured...
December 31, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28033128/renal-function-of-cyclin-m2-mg2-transporter-maintains-blood-pressure
#9
Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki
OBJECTIVES: Epidemiological studies have shown that magnesium intake/excretion is inversely correlated with blood pressure (BP), and artificial supplementation of magnesium was able to prevent hypertension. However, there has been no molecular genetic study showing the importance of magnesium homeostasis in BP regulation. METHODS: We analyzed magnesium content and BP of mice lacking genes encoding cyclin M (CNNM) Mg transporter family proteins. RESULTS: Systemic heterozygotes and the kidney-specific homozygotes for Cnnm2-deficient alleles are both viable and show hypomagnesemia, indicating the important function of CNNM2 in maintaining magnesium homeostasis in the kidney...
March 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27992801/development-of-a-colloidal-gold-immunochromatographic-strip-for-rapid-detection-of-streptococcus-agalactiae-in-tilapia
#10
Wu Wen-de, Li Min, Chen Ming, Li Li-Ping, Wang Rui, Chen Hai-Lan, Chen Fu-Yan, Mi Qiang, Liang Wan-Wen, Chen Han-Zhong
A colloidal gold immunochromatographic strip was developed for rapid detection of Streptococcus agalactiae (S. agalactiae) infection in tilapia. The monoclonal antibodies (mAb) 4C12 and 3A9 were used to target S. agalactiae as colloidal gold-mAb conjugate and captured antibody, respectively. The colloidal gold immunochromatographic strip was assembled via routine procedures. Optimal pH and minimum antibody levels in the reaction system for gold colloidal-mAb 4C12 conjugation were pH 7.4 and 18μg/mL, respectively...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27987129/the-application-of-wrapping-ureter-by-a-pedicled-gastrocolic-omentum-flap-combined-with-an-artificial-external-scaffold-to-prevent-stoma-stenosis-in-rabbit-after-ureterocutaneostomy
#11
Shigeng Zhang, Fei Gao, Chong Xue, Nan Zhang, Feng Gao, Shaojiang Li, Jiaming Wen
OBJECTIVE: To evaluate the feasibility and possibility of wrapping ureter by a pedicled gastrocolic omentum flap combined with an artificial ureter external scaffold to prevent stoma stenosis in rabbit after ureterocutaneostomy. METHODS: Forty male New Zealand rabbits were involved in this study. For application of ureterocutaneostomy, the right ureter was wrapped by a pedicled gastrocolic omentum flap and combined with application of an artificial external scaffold, which served as experimental side...
December 16, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27977906/new-insights-into-the-effects-of-biomaterial-chemistry-and-topography-on-the-morphology-of-kidney-epithelial-cells
#12
Frits Hulshof, Carolien Schophuizen, Milos Mihajlovic, Clemens van Blitterswijk, Rosalinde Masereeuw, Jan de Boer, Dimitrios Stamatialis
Increasing incidence of renal pathology in the western world calls for innovative research for the development of cell-based therapies such as a Bio-artificial kidney (BAK) device. To fulfill the multitude of kidney functions, the core component of the BAK is a "living membrane" consisting of a tight kidney cell monolayer with preserved functional organic ion transporters cultured on a polymeric membrane surface. This membrane, on one side, is in contact with blood and therefore there should have excellent blood compatibility whereas on the other side should facilitate functional monolayer formation...
December 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27920250/renal-anemia-model-mouse-established-by-transgenic-rescue-with-an-erythropoietin-gene-lacking-kidney-specific-regulatory-elements
#13
Ikuo Hirano, Norio Suzuki, Shun Yamazaki, Hiroki Sekine, Naoko Minegishi, Ritsuko Shimizu, Masayuki Yamamoto
The erythropoietin (Epo) gene is under tissue-specific inducible regulation. Because the kidney is the primary EPO-producing tissue in adults, impaired EPO production in chronic kidney disorders results in serious renal anemia. The Epo gene contains a liver-specific enhancer in the 3' region, but the kidney-specific enhancer for gene expression in renal EPO-producing (REP) cells remains elusive. Here, we examined a conserved upstream element for renal Epo regulation (CURE) region that spans 17.4 kb to 3.6 kb upstream of the Epo gene and harbors several phylogenetically conserved elements...
February 15, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27901544/quantitative-urinalysis-using-aggregation-induced-emission-bioprobes-for-monitoring-chronic-kidney-disease
#14
Tong Chen, Ni Xie, Lucia Viglianti, Yabin Zhou, Hui Tan, Ben Zhong Tang, Youhong Tang
Early detection and appropriate management of chronic kidney disease can reduce the progression of kidney failure and cardiovascular disease. The urine albumin to creatinine ratio (UACR) test is a standard urine test for identifying individuals at high risk of developing progressive kidney disease. In this study, IDATPE, a novel fluorescent probe with aggregation-induced emission (AIE) features, is successfully developed for creatinine detection and quantitation. An excellent correlation between fluorescent light intensity and creatinine concentration is achieved...
February 22, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/27875647/what-pacemakers-can-teach-us-about-the-ethics-of-maintaining-artificial-organs
#15
Katrina Hutchison, Robert Sparrow
One day soon it may be possible to replace a failing heart, liver, or kidney with a long-lasting mechanical replacement or perhaps even with a 3-D printed version based on the patient's own tissue. Such artificial organs could make transplant waiting lists and immunosuppression a thing of the past. Supposing that this happens, what will the ongoing care of people with these implants involve? In particular, how will the need to maintain the functioning of artificial organs over an extended period affect patients and their doctors and the responsibilities of those who manufacture such devices? Drawing on lessons from the history of the cardiac pacemaker, this article offers an initial survey of the ethical issues posed by the need to maintain and service artificial organs...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27866810/histological-characterisation-of-visceral-changes-in-a-patient-with-type-2-gaucher-disease-treated-with-enzyme-replacement-therapy
#16
Yuko Tezuka, Mitsumasa Fukuda, Shohei Watanabe, Takeshi Nakano, Kentaro Okamoto, Kazuyo Kuzume, Yoshiaki Yano, Mariko Eguchi, Minenori Ishimae, Eiichi Ishii, Tatsuhiko Miyazaki
Gaucher disease is a lysosomal storage disease caused by deficiency of glucocerebrosidase and accumulation of glucocerebroside. Three major sub-types have been described, type 2 is an acute neurological form that exhibits serious general symptoms and poor prognosis, compared with the other types. This case was a girl diagnosed with type 2 Gaucher disease at 12months of age who presented with poor weight gain from infancy, stridor, hypertonia, hepatosplenomegaly, trismus and an eye movement disorder. Enzyme replacement therapy (ERT) was administered, but she had frequent myoclonus and developmental regression...
November 12, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27863865/solubility-of-indium-tin-oxide-in-simulated-lung-and-gastric-fluids-pathways-for-human-intake
#17
Jens Christian Østergård Andersen, Alastair Cropp, Diane Caroline Paradise
From being a metal with very limited natural distribution, indium (In) has recently become disseminated throughout the human society. Little is known of how In compounds behave in the natural environment, but recent medical studies link exposure to In compounds to elevated risk of respiratory disorders. Animal tests suggest that exposure may lead to more widespread damage in the body, notably the liver, kidneys and spleen. In this paper, we investigate the solubility of the most widely used In compound, indium-tin oxide (ITO) in simulated lung and gastric fluids in order to better understand the potential pathways for metals to be introduced into the bloodstream...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27847969/-migration-speed-of-uropathogens-determination-in-the-ureteral-splint-in-a-practice-like-in-vitro-model
#18
H Braunwarth, F H H Brill, J Steinmann, D Hegeholz, W Droste
BACKGROUND: A urostomy with an ileum conduit or a skin fistula leads to a high infection risk for the kidneys and the ureter of the patient. Therefore, the prevention of retrograde colonization of the artificial drain (splint) with e. g. contaminated urine is the most important objective of infection prevention measurements. We performed an in vitro experiment to determine the migration speed of clinically relevant bacteria in a commercially available splint catheter system. METHODS: The migration speed of bacteria in commonly used splint catheters was determined in a practice-like in vitro model...
February 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27777049/molecular-changes-in-appearance-of-a-cancer-cell-among-normal-hek293t-cells
#19
Jihye Chung, Shunsuke Aburaya, Wataru Aoki, Mitsuyoshi Ueda
In very early stages of cancer development, one or a few cells expressing cancer-associated genes appear among a much larger number of surrounding normal cells. To analyze the molecular changes induced by this co-existence, we artificially prepared transformed cells with complete loss of tumor suppressor gene, SCRIB, among normal human embryonic kidney (HEK293T) cells. A cell strain with SCRIB-knockout was successfully constructed by using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 nuclease system and co-cultured with normal cells...
October 21, 2016: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/27770197/the-endogenous-development-and-pathogenicity-of-eimeria-anseris-kotlan-1932-in-domestic-goslings
#20
Hongqin Song, Dandan Liu, Jinjun Xu, Lili Wu, Yabin Dai, Mei Liu, Jianping Tao
Twenty-one, 25-day-old, artificially reared, coccidia-free goslings (Anser cygnoides var. domestica) were inoculated orally with 0.5 × 10(4), 1 × 10(4), or 100 × 10(4) sporulated oocysts of Eimeria anseris and sacrificed at intervals from 24 to 216 h post-inoculation (HPI). Nine uninfected goslings served as negative controls. Parts of the visceral organs from goslings, including the intestines, kidneys, and liver, were fixed, sectioned, and observed microscopically. The results revealed that two generations of meronts occurred in the life cycle of E...
January 2017: Parasitology Research
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