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https://www.readbyqxmd.com/read/28602971/new-developments-in-hepatorenal-syndrome
#1
Ayse L Mindikoglu, Stephen C Pappas
Hepatorenal Syndrome (HRS) continues to be one of the major complications of decompensated cirrhosis leading to death in the absence of liver transplantation. Challenges in precisely evaluating renal function in the patient with cirrhosis remain due to the limitations of serum creatinine (Cr) alone in estimating glomerular filtration rate (GFR); current GFR estimating models appear to underestimate renal function. Newer models incorporating renal biomarkers, such as the Cr-Cystatin C GFR Equation for Cirrhosis appear to more accurately estimate true GFR...
June 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28583529/association-between-the-fertile-period-and-live-birth-post-kidney-transplantation-a-retrospective-single-center-cohort-study
#2
Y Itabashi, Y Ohashi, M Muramatsu, T Kawamura, Y Hyodo, Y Hamasaki, S Shishido, K Sakai, T Maemura, M Morita, A Aikawa
BACKGROUND: Despite restoration of fertility after kidney transplantation, the benefit is limited in female kidney recipients. Our objective is to determine the reasons for this discrepancy. METHODS: We evaluated 315 women who underwent kidney transplantation from 1983 to 2015 (a median of age at transplantation [10th-90th percentile] of 32 years [7-55 years]); 230 recipients between the ages of 15 to 49 years old as of March 2016 were observed. RESULTS: We experienced 10 abortions and 21 live births from our 23 recipients and 2 abortions and 7 live births in 7 recipients from other transplant center...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28571622/reprint-of-development-of-methods-for-avian-oil-toxicity-studies-using-the-double-crested-cormorant-phalacrocorax-auritus
#3
Fred Cunningham, Karen Dean, Katie Hanson-Dorr, Kendal Harr, Kate Healy, Katherine Horak, Jane Link, Susan Shriner, Steven Bursian, Brian Dorr
Oral and external dosing methods replicating field exposure were developed using the double crested cormorant (DCCO) to test the toxicity of artificially weathered Deepwater Horizon Mississippi Canyon 252 oil. The majority of previous oil dosing studies conducted on wild-caught birds used gavage methods to dose birds with oil and determine toxicity. However, rapid gut transit time of gavaged oil likely reduces oil absorption. In the present studies, dosing relied on injection of oil into live feeder fish for oral dosing of these piscivorous birds, or applying oil to body contour feathers resulting in transdermal oil exposure and oral exposure through preening...
May 29, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28570550/dissection-and-culture-of-mouse-embryonic-kidney
#4
Bejan Aresh, Christiane Peuckert
The goal of this protocol is to describe a method for the dissection, isolation, and culture of mouse metanephric rudiments. During mammalian kidney development, the two progenitor tissues, the ureteric bud and the metanephric mesenchyme, communicate and reciprocally induce cellular mechanisms to eventually form the collecting system and the nephrons of the kidney. As mammalian embryos grow intrauterine and therefore are inaccessible to the observer, an organ culture has been developed. With this method, it is possible to study epithelial-mesenchymal interactions and cellular behavior during kidney organogenesis...
May 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28566885/artificial-liver-support-in-pigs-with-acetaminophen-induced-acute-liver-failure
#5
Guo-Lin He, Lei Feng, Lei Cai, Chen-Jie Zhou, Yuan Cheng, Ze-Sheng Jiang, Ming-Xin Pan, Yi Gao
AIM: To establish a reversible porcine model of acute liver failure (ALF) and treat it with an artificial liver system. METHODS: Sixteen pigs weighing 30-35 kg were chosen and administered with acetaminophen (APAP) to induce ALF. ALF pigs were then randomly assigned to either an experimental group (n = 11), in which a treatment procedure was performed, or a control group (n = 5). Treatment was started 20 h after APAP administration and continued for 8 h. Clinical manifestations of all animals, including liver and kidney functions, serum biochemical parameters and survival times were analyzed...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28550374/performance-of-an-artificial-multi-observer-deep-neural-network-for-fully-automated-segmentation-of-polycystic-kidneys
#6
Timothy L Kline, Panagiotis Korfiatis, Marie E Edwards, Jaime D Blais, Frank S Czerwiec, Peter C Harris, Bernard F King, Vicente E Torres, Bradley J Erickson
Deep learning techniques are being rapidly applied to medical imaging tasks-from organ and lesion segmentation to tissue and tumor classification. These techniques are becoming the leading algorithmic approaches to solve inherently difficult image processing tasks. Currently, the most critical requirement for successful implementation lies in the need for relatively large datasets that can be used for training the deep learning networks. Based on our initial studies of MR imaging examinations of the kidneys of patients affected by polycystic kidney disease (PKD), we have generated a unique database of imaging data and corresponding reference standard segmentations of polycystic kidneys...
May 26, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28537051/artificial-ureter-in-patients-with-extensive-ureteral-damage
#7
Mohammad Yazdani, Amir Javid, Mehrdad Mohammadi Sichani, Mohammad Reza Gharaati, Emad Yazdani
PURPOSE: loss of significant lengths of ureter when substitution with bowel or bladder fails is a disaster in urology. This study is conducted to evaluate the results of subcutaneous nephron-vesical bypass (SNVB) in ureteral damage of different etiologies. MATERIALS AND METHODS: Seventeen SNVB were employed in patients with ureteral injuries. We employed a device consisted of an internal silicone tube covered by a coiled PTFE tube to replace the ureter. This is called artificial ureter (AU)...
May 23, 2017: Urology Journal
https://www.readbyqxmd.com/read/28534088/the-ppar-gamma-binding-sequence-pal3-is-necessary-for-basal-but-dispensable-for-high-fat-diet-regulated-human-renin-expression-in-the-kidney
#8
Peter Lachmann, Jenny Selbmann, Linda Hickmann, Bernd Hohenstein, Christian Hugo, Vladimir T Todorov
We reported earlier that PPAR-gamma regulates renin transcription through a human-specific atypical binding sequence termed hRen-Pal3. Here we developed a mouse model to investigate the functional relevance of the hRen-Pal3 sequence in vivo since it might be responsible for the increased renin production in obesity and thus for the development of accompanying arterial hypertension. We used bacterial artificial chromosome construct and co-placement strategy to generate two transgenic mouse lines expressing the human renin gene from identical genomic locus without affecting the intrinsic mouse renin expression...
May 22, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28522333/development-of-qsars-for-parameterizing-physiology-based-toxicokinetic-models
#9
Dimosthenis Α Sarigiannis, Krystalia Papadaki, Periklis Kontoroupis, Spyros P Karakitsios
A Quantitative Structure Activity Relationship (QSAR) model was developed in order to predict physicochemical and biochemical properties of industrial chemicals of various groups. This model was based on the solvation equation, originally proposed by Abraham. In this work Abraham's solvation model got parameterized using artificial intelligence techniques such as artificial neural networks (ANNs) for the prediction of partitioning into kidney, heart, adipose, liver, muscle, brain and lung for the estimation of the bodyweight-normalized maximal metabolic velocity (Vmax) and the Michaelis - Menten constant (Km)...
May 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28509945/ant-mediated-indirect-negative-effects-of-aphids-on-spider-mites-living-on-the-same-plant
#10
Masaaki Adachi, Shuichi Yano
Some aphid species are known to have mutualistic relationships with tending ants; that is, the aphids supply the ants with honeydew and are protected by the ants. Although spider mites and honeydew-producing aphids often live on the same host plant, it has not previously been determined whether the ants tending these aphids affect spider mite survival. Using replicated microcosms, each containing an artificial ant nest, we compared experimentally the survival of two-spotted spider mites on kidney bean plants with and without cowpea aphids...
May 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28469243/reconstitution-of-ovarian-function-following-transplantation-of-primordial-germ-cells
#11
Ming Zeng, Xiaoyan Sheng, David L Keefe, Lin Liu
Ovarian aging occurs earlier than somatic aging. We tested the hypothesis that ovarian functions could be artificially reconstructed by transplantation of primordial germ cells (PGCs). We compared various methods for transplantation of PGCs aggregated with gonadal somatic cells and showed that reconstituted ovaries exhibited folliculogenesis after transplantation of PGCs-aggregates into either kidney capsule or ovarian bursa. Neo-oogenesis occurred early after transplantation, as evidenced by the presence of prophase I meiocytes displaying homologous pairing...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28466293/-renal-replacement-therapy-in-acute-kidney-injury
#12
REVIEW
S J Klein, M Joannidis
Acute kidney injury is still a common complication in intensive care units and is associated with a significantly increased risk for morbidity and mortality. Various treatment concepts, like continuous renal replacement therapy (RRT) or (modified) intermittent procedures, as well as different methods of anticoagulation and the general decision of when and if to initiate RRT have to be considered by the treating physician. While giving vital input on when to initiate RRT, the German ELAIN (Early versus late initiation of renal replacement therapy in critically ill patients) trial and the French AKIKI (The artificial kidney initiation in kidney injury) trial raised many more questions...
June 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28457645/toxicological-and-thermoregulatory-effects-of-feather-contamination-with-artificially-weathered-mc-252-oil-in-western-sandpipers-calidris-mauri
#13
Ivan Maggini, Lisa V Kennedy, Steven J Bursian, Karen M Dean, Alexander R Gerson, Kendal E Harr, Jane E Link, Chris A Pritsos, Karen L Pritsos, Christopher G Guglielmo
The external contamination of bird feathers with crude oil might have effects on feather structure and thus on thermoregulation. We tested the thermoregulatory ability of western sandpipers (Calidris mauri) in a respirometry chamber with oil applied either immediately prior, or three days before the experiment. The birds were then exposed to a sliding cold temperature challenge between 27°C and -3°C to calculate thermal conductance. After the experiment, a large blood sample was taken and the liver extracted to measure a range of parameters linked to toxicology and oxidative stress...
April 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28449660/selective-measurement-of-%C3%AE-smooth-muscle-actin-why-%C3%AE-actin-can-not-be-used-as-a-housekeeping-gene-when-tissue-fibrosis-occurs
#14
Apor Veres-Székely, Domonkos Pap, Erna Sziksz, Eszter Jávorszky, Réka Rokonay, Rita Lippai, Kálmán Tory, Andrea Fekete, Tivadar Tulassay, Attila J Szabó, Ádám Vannay
BACKGROUND: Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increased expression of α smooth muscle actin (α-SMA) that belongs to the family of the six conserved actin isoforms showing high degree homology. The aim of the present study was to develop real-time PCRs that clearly discriminate α-SMA and ß-actin from other actin isoforms...
April 27, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28447929/five-year-follow-up-on-transplanted-organs-from-donors-after-brain-death-after-acute-stroke
#15
Vera Spatenkova, Eva Pokorna, Petr Suchomel
OBJECTIVES: Efficient intensive care donor management can help alleviate the shortage of organs for transplant. The aim of this study was to investigate the efficiency of management of donors after brain death from our neurointensive care unit. MATERIALS AND METHODS: We conducted a prospective observational 5-year follow-up on 29 transplanted organs from 14 brain-dead donors after acute stroke (7 subarachnoid and 4 intracerebral hemorrhages, 3 ischemic strokes)...
April 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28434235/recirculation-zone-length-in-renal-artery-is-affected-by-flow-spirality-and-renal-to-aorta-flow-ratio
#16
Ashkan Javadzadegan, David Fulker, Tracie Barber
Haemodynamic perturbations such as flow recirculation zones play a key role in progression and development of renal artery stenosis, which typically originate at the aorta-renal bifurcation. The spiral nature of aortic blood flow, division of aortic blood flow in renal artery as well as the exercise conditions have been shown to alter the haemodynamics in both positive and negative ways. This study focuses on the combinative effects of spiral component of blood flow, renal-to-aorta flow ratio and the exercise conditions on the size and distribution of recirculation zones in renal branches using computational fluid dynamics technique...
April 24, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28388934/isolation-and-identification-of-a-new-strain-of-hirame-rhabdovirus-hirrv-from-japanese-flounder-paralichthys-olivaceus-in-china
#17
Jialin Zhang, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
BACKGROUND: Hirame rhabdovirus virus (HIRRV) is a rhabdovirus that causes acute hemorrhage disease in fish culture, resulting in a great economic loss in parts of Asia and Europe. METHODS: In this study, we isolated a virus strain named as CNPo2015 from cultured Japanese flounder in Shandong province, China. Cell isolation, electron microscopic observation, RT-PCR detection and phylogenetic analysis were used for virus identification. Further, artificial infection experiment was conducted for virulence testing...
April 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28385037/new-for-old-coagulum-lithotomy-vs-a-novel-bioadhesive-for-complete-removal-of-stone-fragments-in-a-comparative-study-in-an-ex-vivo-porcine-model
#18
Dominik Stefan Schoeb, Martin Schoenthaler, Daniel Schlager, Ralf Petzold, Katharina Richter, Ingo Grunwald, Ulrich Wetterauer, Arkadiusz Miernik, Simon Hein
OBJECTIVES: To evaluate a recently reported new bioadhesive system for the retrieval of small residual fragments (RFs) after intracorporeal lithotripsy, we systematically compared this system with coagulum lithotomy in retrograde intrarenal surgery. MATERIALS AND METHODS: We extracted 30 human stone fragments (≤1 mm) in an ex vivo porcine kidney model using a flexible ureteroscope for three groups: (1) the novel bioadhesive, (2) autologous blood as a natural adhesive, and (3) (control group) a conventional retrieval basket...
June 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28383772/aberrant-expression-of-mico1-and-mico1os-in-deceased-somatic-cell-nuclear-transfer-calves
#19
Guan-Nan Wang, Wen-Zhi Yang, Da Xu, Dong-Jie Li, Cui Zhang, Wei-Na Chen, Shi-Jie Li
Incomplete reprogramming of a donor nucleus following somatic cell nuclear transfer (SCNT) results in aberrant expression of developmentally important genes, and is the primary source of the phenotypic abnormalities observed in cloned animals. Expression of non-coding RNAs in the murine Dlk1-Dio3 imprinted domain was previously shown to correlate with the pluripotency of mouse induced pluripotent stem cells. In this study, we examined the transcription of the bovine orthologs from this locus, MICO1 (Maternal intergenic circadian oscillating 1) and MICO1OS (MICO1 opposite strand), in tissues from artificially inseminated and SCNT calves that died during the perinatal period...
April 6, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28381092/in-vitro-comparison-of-maximum-pressure-developed-by-irrigation-systems-in-a-kidney-model
#20
Silvia Proietti, Laurian Dragos, Bhaskar K Somani, Salvatore Butticè, Michele Talso, Esteban Emiliani, Mohammed Baghdadi, Guido Giusti, Olivier Traxer
PURPOSE: To evaluate in vitro the maximum pressure generated in an artificial kidney model when people of different levels of strengths used various irrigation systems. MATERIALS AND METHODS: Fifteen people were enrolled and divided in 3 groups based on their strengths. Individual strength was evaluated according to the maximum pressure each participant was able to achieve using an Encore™ Inflator. The irrigation systems evaluated were: T-FlowTM Dual Port, HilineTM, continuous flow single action pumping system (SAPSTM) with the system close and open, Irri-flo IITM, a simple 60-ml syringe and PeditrolTM ...
April 5, 2017: Journal of Endourology
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