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Zhongbo Liu, Pasha Apontes, Ekaterina V Fomenko, Nan Chi, Victor L Schuster, Irwin J Kurland, Jeffrey E Pessin, Yuling Chi
One of the main causes of hyperglycemia is inefficient or impaired glucose utilization by skeletal muscle, which can be exacerbated by chronic high caloric intake. Previously, we identified a natural compound, mangiferin (MGF) that improved glucose utilization in high fat diet (HFD)-induced insulin resistant mice. To further identify the molecular mechanisms of MGF action on glucose metabolism, we conducted targeted metabolomics and transcriptomics studies of glycolyic and mitochondrial bioenergetics pathways in skeletal muscle...
January 9, 2018: International Journal of Molecular Sciences
Eugene E Kotomin, Vladimir Kuzovkov, Anatoli Popov, Joachim Maier, Rafael Vila
The annealing kinetics of the primary electronic $F$-type color centers (oxygen vacancies with trapped one or two electrons) is analysed for three ionic materials (Al$_2$O$_3$, MgO and MgF$_2$) exposed to intensive irradiation by electrons, neutrons and heavy swift ions. Phenomenological theory of diffusion- controlled recombination of the $F$-type centers with much more mobile interstitial ions (complementary hole centers) allows us to extract from experimental data the migration energy of interstitials and pre-exponential factor of diffusion...
December 12, 2017: Journal of Physical Chemistry. A
Jeffrey Crawford, Pamela Sue Becker, James O Armitage, Douglas W Blayney, Julio Chavez, Peter Curtin, Shira Dinner, Thomas Fynan, Ivana Gojo, Elizabeth A Griffiths, Shannon Hough, Dwight D Kloth, David J Kuter, Gary H Lyman, Mary Mably, Sudipto Mukherjee, Shiven Patel, Lia E Perez, Adam Poust, Raajit Rampal, Vivek Roy, Hope S Rugo, Ayman A Saad, Lee S Schwartzberg, Sepideh Shayani, Mahsa Talbott, Saroj Vadhan-Raj, Sumithira Vasu, Martha Wadleigh, Peter Westervelt, Jennifer L Burns, Lenora Pluchino
Myeloid growth factors (MGFs) are given as supportive care to patients receiving myelosuppressive chemotherapy to reduce the incidence of neutropenia. This selection from the NCCN Guidelines for MGFs focuses on the evaluation of regimen- and patient-specific risk factors for the development of febrile neutropenia (FN), the prophylactic use of MGFs for the prevention of chemotherapy-induced FN, and assessing the risks and benefits of MGF use in clinical practice.
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
Pamela Maree Ramirez, Barry Peterson, Christine Holtshopple, Kristina Borja, Vincent Torres, Lucille Valdivia-Peppers, Julio Harriague, Melanie D Joe
PURPOSE: Four incident reports involving missed doses of myeloid growth factors (MGFs) triggered the need for an outcome-driven initiative. From March 1, 2015, to February 29, 2016, at University of California Irvine Health Chao Infusion Center, 116 of 3,300 MGF doses were missed (3.52%), including pegfilgrastim, filgrastim, and sargramostim. We hypothesized that with the application of Lean Six Sigma methodology, we would achieve our primary objective of reducing the number of missed MGF doses to < 0...
November 14, 2017: Journal of Oncology Practice
Marco A S Fortes, Maria V M Scervino, Gabriel N Marzuca-Nassr, Kaio F Vitzel, Carlos H da Justa Pinheiro, Rui Curi
Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whether the overload-induced hypertrophy can counteract the hypotrophy associated to the diabetic state. The experiments were performed in oxidative (soleus) or glycolytic (EDL) muscles...
2017: Frontiers in Physiology
Alexander Rehmer, Kerstin Scheurell, Gudrun Scholz, Erhard Kemnitz
The fluorolytic sol-gel synthesis for binary metal fluorides (AlF₃, CaF₂, MgF₂) has been extended to ternary and quaternary alkaline earth metal fluorides (CaAlF₅, Ca₂AlF₇, LiMgAlF₆). The formation and crystallization of nanoscopic ternary CaAlF₅ and Ca₂AlF₇ sols in ethanol were studied by (19)F liquid and solid state NMR (nuclear magnetic resonance) spectroscopy, as well as transmission electron microscopy (TEM). The crystalline phases of the annealed CaAlF₅, Ca₂AlF₇, and LiMgAlF₆ xerogels between 500 and 700 °C could be determined by X-ray powder diffraction (XRD) and (19)F solid state NMR spectroscopy...
November 2, 2017: Nanomaterials
A L Rusanov, N A Petushkova, E V Poverennaya, K V Nakhod, O V Larina, A V Lisitsa, N G Luzgina
The effects of sodium dodecyl sulfate (25 mg/ml) and Triton X-100 (12.5 mg/ml and 25 mg/ml) on the HaCaT immortalized keratinocytes exposed to these surfactants for 48 h were studied. Using shotgun proteomics, a comparative analysis of the proteomic profiles of control and experimental cells after surfactants exposure was carried out. 260 common proteins were identified in control and experimental cells; 33 proteins were found in cells exposed to all three treatments, but not in control cells. These 33 proteins apparently reflect a nonspecific (universal) response of cells to toxic damage by the surfactants...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
R M Ahmedbeyli
The aim of the study was to evaluate the efficacy of dental caries prevention program with 3 years follow-up in children living in areas with fluoride and iodine deficiency. The study involved 625 school-aged children aged 6, 12 and 15 years receiving endogenous prevention with fluoridated and iodinated salt (300±50 mgF/kg and 40±10 mgI/kg). Enamel and dentine concentrations of CA, P, F and I were measured in 98 intact deciduous teeth by X-ray microanalysis before and after prevention program. Enamel and dentin microhardness was assessed in the same 98 teeth by Vickers Hardness Test...
2017: Stomatologii︠a︡
José M Garrido-Balsells, F Javier Lopez-Martinez, Miguel Castillo-Vázquez, Antonio Jurado-Navas, Antonio Puerta-Notario
We analyze the performance of a free-space optical (FSO) link affected by atmospheric turbulence and line-of-sight (LOS) blockage. For this purpose, the atmospheric turbulence induced fading is modeled by the ℳ distribution, which includes the Gamma-Gamma distribution as special case. We exploit the fact that the physical interpretation of the ℳ distribution allows to split the optical energy through the propagation link into three different components: two coherent components and one incoherent scatter component...
October 16, 2017: Optics Express
Jianhua He, Lili Dong, Kang Xu, Yuna Qian, Chunli Wang, Yongqiang Sha, Juila Li Zhong, Wanqian Liu, Yonggang Lv, Yang Song, Li Yang
OBJECTIVE: To evaluate the effects of mechano growth factor E peptide (MGF) on the invasive properties of melanoma cells. RESULTS: Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h. Their invasive properties were investigated by transwell assay. Cytoskeleton reorganization was assessed via staining with phalloidin-FITC; lysyl oxidase (LOX) family gene expression was tested by qRT-PCR, and western blotting was used to detect expression of the matrix metalloproteinases (MMPs) and endoplasmic reticulum (ER) stress...
October 6, 2017: Biotechnology Letters
Arudo Hiraoka, Satsuki Fukushima, Shigeru Miyagawa, Yasushi Yoshikawa, Shunsuke Saito, Keitaro Domae, Taichi Sakaguchi, Koichi Toda, Yoshiki Sawa
OBJECTIVES: Graft flow in coronary artery bypass grafting (CABG) may be determined by the anatomical and pathological characteristics of the coronary artery and target myocardium. Our goal was to explore the relationships between graft flow and the cardiac/coronary parameters in CABG. METHODS: We enrolled 63 patients who underwent isolated CABG and were examined by cardiac computed tomography. We statistically analysed the correlation between the intraoperative graft flow, such as the mean graft flow (MGF) or the pulsatile index (PI), and the computed tomography scan-based anatomy of the coronary artery tree and the left ventricle in 104 individually bypassed grafts...
November 1, 2017: European Journal of Cardio-thoracic Surgery
Guang-Kai Xu, Chen-Yu Sun, Xiao-Ying Qin, Yu Han, Yi Li, Guo-Yong Xie, Qin Min-Jian
The present study was designed to explore the mechanism by which ethanol extract of Bombax ceiba leaves (BCE) and its main constituent mangiferin (MGF) affect diabetic nephropathy by combating oxidative stress. Oral administration of BCE and MGF to normal and streptozotocin (STZ)-induced diabetic mice were carried out. Fasting blood glucose, 24-h urinary albumin, serum creatinine, and blood urea nitrogen were tested, histopathology, and immunohistochemical analysis of kidney tissues were performed. Moreover, mesangial cells were treated with BCE and MGF for 48 h with or without 25 mmol·L(-1) of glucose...
August 2017: Chinese Journal of Natural Medicines
Yongqiang Sha, Yonggang Lv, Zhiling Xu, Li Yang, Xiaoying Hao, Ruli Afandi
AIMS: Severe hypoxia always inhibits the cell proliferation, osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), and hinders bone defect repair. Herein we explored the effects of mechano-growth factor (MGF) E peptide on the proliferation and osteogenic differentiation of BMSCs under severe hypoxia. MATERIALS AND METHODS: CoCl2 was utilized to simulate severe hypoxia. MTS was used to detect cell viability. Cell proliferation was verified through flow cytometry and EdU assay...
November 15, 2017: Life Sciences
Thanaphum Osathanon, Jeeranan Manokawinchoke, Hiroshi Egusa, Prasit Pavasant
Notch signaling is involved in osteogenic differentiation; however, its role differs depending on cell type and differentiation stage. Here, we investigated the involvement of Notch signaling in the osteogenic differentiation of retinoic acid-treated embryoid bodies derived from mouse gingival fibroblast-derived induced pluripotent stem cells (mGF-iPSCs). When cultured in osteogenic media, mGF-iPSCs showed an increase in their expression of osteogenic marker genes and deposited a mineralized matrix. Furthermore, increased levels of mRNA for Notch1, Notch2, and Hey1 were observed...
2017: Journal of Oral Science
Charlotte Suetta
In order to study the influence of disuse and aging on skeletal muscle homeostasis, different human models were employed. Effects of chronic disuse were investigated in elderly patients suffering from uni-lateral hip-osteoarthritis, whereas the effect of short-term disuse (4 and 14 days of unilateral lower limb immobilisation) was assessed in healthy young and old individuals. In summary, chronic muscle disuse in the elderly was associated with marked quantitative as well as qualitative neuromuscular impairments...
August 2017: Danish Medical Journal
Sandeep Kumar, Thogluva Janardhanan Dhilip Kumar
Porous metal-graphyne framework (MGF) made up of graphyne linker decorated with lithium has been investigated for hydrogen storage. Applying density functional theory spin-polarized generalized gradient approximation with the Perdew-Burke-Ernzerhof functional containing Grimme's diffusion parameter with double numeric polarization basis set, the structural stability, and physicochemical properties have been analyzed. Each linker binds two Li atoms over the surface of the graphyne linker forming MGF-Li8 by Dewar coordination...
August 30, 2017: ACS Applied Materials & Interfaces
A López-Herradón, R Fujikawa, M Gómez-Marín, J P Stedile-Lovatel, F Mulero, J A Ardura, P Ruiz, I Muñoz, P Esbrit, I Mahíllo-Fernández, A Ortega-de Mues
Evidence suggests that chiropractic manipulation might exert positive effects in osteoporotic patients. The aim of this study was to evaluate the effects of chiropractic manipulation on bone structure and skeletal muscle in rats with bone loss caused by ovariectomy (OVX). The 6-month old Sprague-Dawley rats at 10 weeks following OVX or sham operation (Sh) did not suffer chiropractic manipulation (NM group) or were submitted to true chiropractic manipulation using the chiropractic adjusting instrument Activator V(®) three times/week for 6 weeks as follows: Force 1 setting was applied onto the tibial tubercle of the rat right hind limb (TM group), whereas the corresponding left hind limb received a false manipulation (FM group) consisting of ActivatorV(®) firing in the air and slightly touching the tibial tubercle...
July 28, 2017: Calcified Tissue International
Jason J Tang, Jewel L Podratz, Miranda Lange, Heidi J Scrable, Mi-Hyeon Jang, Anthony J Windebank
Mechano growth factor (MGF) is a splice variant of IGF-1 first described in skeletal muscle. MGF induces muscle cell proliferation in response to muscle stress and injury. In control mice we found endogenous expression of MGF in neurogenic areas of the brain and these levels declined with age. To better understand the role of MGF in the brain, we used transgenic mice that constitutively overexpressed MGF from birth. MGF overexpression significantly increased the number of BrdU+ proliferative cells in the dentate gyrus (DG) of the hippocampus and subventricular zone (SVG)...
July 7, 2017: Molecular Brain
Tomas Cajka, Oliver Fiehn
This protocol describes the analysis, specifically the identification, of blood plasma lipids. Plasma lipids are extracted using methyl tert-butyl ether (MTBE), methanol, and water followed by separation and data acquisition of isolated lipids using reversed-phase liquid chromatography coupled to quadrupole/time-of-flight mass spectrometry (RPLC-QTOFMS) operated in MS/MS mode. For lipid identification, acquired MS/MS spectra are converted to the mascot generic format (MGF) followed by library search using the in-silico MS/MS library LipidBlast...
2017: Methods in Molecular Biology
Dan Sun, Chun-Ze Zhang, Rui-Xue Ran, Yun-Feng Cao, Zuo Du, Zhi-Wei Fu, Chun-Ting Huang, Zhen-Ying Zhao, Wei-Hua Zhang, Zhong-Ze Fang
Mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera Indica L., has been investigated extensively because of its remarkable pharmacological effects. In vitro recombinant UGTs-catalyzed glucuronidation of 4-methylumbelliferone (4-MU) was used to investigate the inhibition of mangiferin and aglycone norathyriol towards various isoforms of UGTs in our study, which evaluated the inhibitory capacity of MGF and its aglycone norathyriol (NTR) towards UDP-glucuronosyltransferase (UGT) isoforms...
June 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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