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https://www.readbyqxmd.com/read/28440368/mangiferin-functionalized-radioactive-gold-nanoparticles-mgf-198-aunps-in-prostate-tumor-therapy-green-nanotechnology-for-production-in-vivo-tumor-retention-and-evaluation-of-therapeutic-efficacy
#1
A Y Al-Yasiri, M Khoobchandani, C S Cutler, L Watkinson, T Carmack, C J Smith, M Kuchuk, S K Loyalka, A B Lugão, K V Katti
We report here an innovative feature of green nanotechnology-focused work showing that mangiferin-a glucose functionalized xanthonoid, found in abundance in mango peels-serves dual roles of chemical reduction and in situ encapsulation, to produce gold nanoparticles with optimum in vivo stability and tumor specific characteristics. The interaction of mangiferin with a Au-198 gold precursor affords MGF-(198)AuNPs as the beta emissions of Au-198 provide unique advantages for tumor therapy while gamma rays are used for the quantitative estimation of gold within the tumors and various organs...
April 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28362741/microresonator-stabilized-extended-cavity-diode-laser-for-supercavity-frequency-stabilization
#2
Jinkang Lim, Anatoliy A Savchenkov, Andrey B Matsko, Shu-Wei Huang, Lute Maleki, Chee Wei Wong
We demonstrate a simple, compact, and cost-effective laser noise reduction method for stabilizing an extended-cavity diode laser to a 3×10<sup>5</sup> finesse mirror Fabry-Perot (F-P) cavity, corresponding to a resonance linewidth of 10 kHz, by using a crystalline MgF<sub>2</sub> whispering gallery mode microresonator. The laser linewidth is reduced to sub-kilohertz such that a stable Pound-Drever-Hall error signal is built up. The wavelength of the pre-stabilized laser is tunable within a large bandwidth covering the high-reflection mirror coating of an F-P supercavity...
April 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28344830/exploring-and-validating-physicochemical-properties-of-mangiferin-through-gastroplus-%C3%A2-software
#3
Rajneet Kaur Khurana, Ranjot Kaur, Manninder Kaur, Rajpreet Kaur, Jasleen Kaur, Harpreet Kaur, Bhupinder Singh
AIM: Mangiferin (Mgf), a promising therapeutic polyphenol, exhibits poor oral bioavailability. Hence, apt delivery systems are required to facilitate its gastrointestinal absorption. The requisite details on its physicochemical properties have not yet been well documented in literature. Accordingly, in order to have explicit insight into its physicochemical characteristics, the present work was undertaken using GastroPlus™ software. RESULTS: Aqueous solubility (0...
March 2017: Future Science OA
https://www.readbyqxmd.com/read/28214583/remediation-of-fluoride-from-drinking-water-using-magnetic-iron-oxide-coated-hydrotalcite-chitosan-composite
#4
Kalimuthu Pandi, Soodamani Periyasamy, Natrayasamy Viswanathan
The present study was performed to examine the probability of magnetic iron oxide fabricated hydrotalcite/chitosan (Fe3O4@HTCS) composite for the removal of excess fluoride content from drinking water. The developed Fe3O4@HTCS composite not only demonstrate the good separation ability but also display an extreme enhanced defluoridation capacity (DC) when compared to other base components and composite. The DCs of Fe3O4@HTCS composite, Fe3O4@HT composite, Fe3O4, HT and CS was found to be 5032, 3041, 1050, 1030 and 52 mgF(-)/kg respectively...
February 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28183052/electronic-structure-of-the-polar-molecules-xf-x-be-mg-ca-with-rovibrational-and-dipole-moment-calculations
#5
Nayla El-Kork, Nariman Abu El Kher, Farah Korjieh, John Anwar Chtay, Mahmoud Korek
A theoretical investigation for the feasibility of laser-cooling is performed through the calculation of accurate potential energy curves, static dipole moments, spectroscopic constants and rovibrational calculations for 24, 26 and 27 highly excited electronic states for BeF, CaF and MgF molecules respectively. In order to understand the electronic structure of their lowest lying electronic states and to learn the characteristic behavior of their chemical bonding, a high level of calculation is realized by using the complete active space self-consistent field (CASSCF) with multi-reference configuration interaction MRCI method including single and double excitations with Davidson correction (+Q) for the three considered molecules...
April 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28146515/soliton-dual-frequency-combs-in-crystalline-microresonators
#6
N G Pavlov, G Lihachev, S Koptyaev, E Lucas, M Karpov, N M Kondratiev, I A Bilenko, T J Kippenberg, M L Gorodetsky
We present a novel compact dual-comb source based on a monolithic optical crystalline MgF<sub>2</sub> multi-resonator stack. The coherent soliton combs generated in the two microresonators of the stack with the repetition rate of 12.1 GHz and difference of 1.62 MHz provided after heterodyning a 300 MHz wide radio frequency comb. An analogous system can be used for dual-comb spectroscopy, coherent LIDAR applications, and massively parallel optical communications.
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28125630/fluoride-regulate-osteoblastic-transforming-growth-factor-%C3%AE-1-signaling-by-mediating-recycling-of-the-type-i-receptor-alk5
#7
Chen Yang, Yan Wang, Hui Xu
This study aimed to preliminary investigate the role of activin receptor-like kinase (ALK) 5 as one of TGF-βR1 subtypes in bone turnover and osteoblastic differentiation induced by fluoride. We analyzed bone mineral density and the expression of genes related with transforming growth factor-β1(TGF-β1) signaling and bone turnover in rats treated by different concentrations of fluoride with or without SB431542 in vivo. Moreover, MTT assay, alkaline phosphatase staining, RT-PCR, immunocytochemical analysis and western blot analysis were used to detect the influence on bone marrow stem cells (BMSC) after stimulating by varying concentration of fluoride with or without SB431542 in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28035768/detection-and-in-vitro-metabolism-of-the-confiscated-peptides-bpc-157-and-mgf-r23h
#8
H D Cox, G D Miller, D Eichner
A new peptide, body protecting compound (BPC), BPC 157, and a variant of mechano-growth factor (MGF), MGF R23H, were identified in confiscated vials. BPC 157 has the amino acid sequence, GEPPPGKPADDAGLV, and is currently under investigation for the promotion of healing and recovery in a variety of tissues. In vitro metabolism experiments in plasma demonstrate that MGF R23H has good stability and should be detectable in urine, while BPC 157 forms a stable metabolite that should be detectable in urine. A weak cation exchange solid phase extraction method was validated for detection of BPC 157 in urine...
December 29, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28025072/enhancing-biopharmaceutical-attributes-of-phospholipid-complex-loaded-nanostructured-lipidic-carriers-of-mangiferin-systematic-development-characterization-and-evaluation
#9
Rajneet Kaur Khurana, Arvind K Bansal, Sarwar Beg, Andrea Julie Burrow, O P Katare, Kamalinder K Singh, Bhupinder Singh
Mangiferin (Mgf), largely expressed out from the leaves and stem bark of Mango, is a potent antioxidant. However, its in vivo activity gets tremendously reduced owing to poor aqueous solubility and inconsistent gastrointestinal absorption, high hepatic first-pass metabolism and high P-gp efflux. The current research work, therefore, was undertaken to overcome the biopharmaceutical hiccups by developing the Mgf-phospholipid complex (PLCs) loaded in nanostructured lipidic carriers (NLCs). The PLCs and NLCs were prepared using refluxing, solvent evaporation and hot emulsification technique, respectively with three molar ratios of Mgf and Phospholipon 90G, i...
December 23, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27958443/tri-band-transparent-conductive-coating-of-indium-tin-oxide
#10
Huafei Du, Mingyun Lv, Junhui Meng, Weiyu Zhu
A tri-band transparent conductive indium tin oxide (In<sub>2</sub>O<sub>3</sub>:Sn, ITO) film for the visible, near-infrared (NIR) and mid-infrared (MIR) was deposited on a sapphire substrate by radio frequency (RF) magnetron sputtering. Deposition parameters, including RF power, substrate temperature, and oxygen flow rate, were optimized to improve the optical property without reducing the conductivity of the film by maximizing the Hall mobility and minimizing the carrier concentration...
December 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27906310/harmonization-of-chaos-into-a-soliton-in-kerr-frequency-combs
#11
V E Lobanov, G V Lihachev, N G Pavlov, A V Cherenkov, T J Kippenberg, M L Gorodetsky
Dissipative Kerr solitons have paved the way to broadband and fully coherent optical frequency combs in microresonators. Here, we demonstrate numerically that slow frequency tuning of the pump laser in conjunction with phase or amplitude modulation corresponding to the free spectral range of the microresonator, provides reliable convergence of an initially excited chaotic comb state to a single dissipative Kerr soliton (DKS) state. The efficiency of this approach depends on both frequency tuning speed and modulation depth...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27898012/hydrodechlorination-of-tetrachloromethane-over-palladium-catalysts-supported-on-mixed-mgf%C3%A2-mgo-carriers
#12
Magdalena Bonarowska, Maria Wojciechowska, Maciej Zieliński, Angelika Kiderys, Michał Zieliński, Piotr Winiarek, Zbigniew Karpiński
Pd/MgO, Pd/MgF₂ and Pd/MgO-MgF₂ catalysts were investigated in the reaction of CCl₄ hydrodechlorination. All the catalysts deactivated in time on stream, but the degree of deactivation varied from catalyst to catalyst. The MgF₂-supported palladium with relatively large metal particles appeared the best catalyst, characterized by good activity and selectivity to C₂-C₅ hydrocarbons. Investigation of post-reaction catalyst samples allowed to find several details associated with the working state of hydrodechlorination catalysts...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27888539/macrophage-depletion-impairs-skeletal-muscle-regeneration-the-roles-of-regulatory-factors-for-muscle-regeneration
#13
Xiaoguang Liu, Yu Liu, Linlin Zhao, Zhigang Zeng, Weihua Xiao, Peijie Chen
Though macrophages are essential for skeletal muscle regeneration, which is a complex process, the roles and mechanisms of the macrophages in the process of muscle regeneration are still not fully understood. The objective of this study is to explore the roles of macrophages and the mechanisms involved in the regeneration of injured skeletal muscle. One hundred and twelve C57BL/6 mice were randomly divided into muscle contusion and macrophages depleted groups. Their gastrocnemius muscles were harvested at the time points of 12 h, 1, 3, 5, 7, 14 d post-injury...
March 2017: Cell Biology International
https://www.readbyqxmd.com/read/27863093/potential-effect-of-mechano-growth-factor-e-domain-peptide-on-axonal-guidance-growth-in-primary-cultured-cortical-neurons-of-rats
#14
Meili Liu, Xufeng Niu, Gang Zhou, Zhengtai Jia, Ping Li, Yubo Fan
Establishing appropriate synaptic connections and plasticity is a critical need in neuronal regeneration and development. Mechano growth factor (MGF) and its C-terminal E-domain peptide with 24 amino acids, MGF-Ct24E, are potential neuroprotective agents. Our preliminary study indicates that Netrin-1 can guide axonal growth and its expression is sensitive to MGF, but how MGF regulates the expression of Netrin-1 and its receptor DCC is still unclear. Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27857315/single-step-fabrication-of-thin-film-linear-variable-bandpass-filters-based-on-metal-insulator-metal-geometry
#15
Calum Williams, Girish Rughoobur, Andrew J Flewitt, Timothy D Wilkinson
A single-step fabrication method is presented for ultra-thin, linearly variable optical bandpass filters (LVBFs) based on a metal-insulator-metal arrangement using modified evaporation deposition techniques. This alternate process methodology offers reduced complexity and cost in comparison to conventional techniques for fabricating LVBFs. We are able to achieve linear variation of insulator thickness across a sample, by adjusting the geometrical parameters of a typical physical vapor deposition process. We demonstrate LVBFs with spectral selectivity from 400 to 850 nm based on Ag (25 nm) and MgF<sub>2</sub> (75-250 nm)...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27851817/outage-probability-of-mrc-for-%C3%AE%C2%BA-%C3%AE-shadowed-fading-channels-under-co-channel-interference
#16
Changfang Chen, Minglei Shu, Yinglong Wang, Ming Yang, Chongqing Zhang
In this paper, exact closed-form expressions are derived for the outage probability (OP) of the maximal ratio combining (MRC) scheme in the κ-μ shadowed fading channels, in which both the independent and correlated shadowing components are considered. The scenario assumes the received desired signals are corrupted by the independent Rayleigh-faded co-channel interference (CCI) and background white Gaussian noise. To this end, first, the probability density function (PDF) of the κ-μ shadowed fading distribution is obtained in the form of a power series...
2016: PloS One
https://www.readbyqxmd.com/read/27738118/egg-quality-in-laying-hens-exposed-to-mycoplasma-gallisepticum-f-strain-attenuated-vaccine
#17
L D S Machado, F F D Santos, C K Togashi, D L D C Abreu, J C Pimentel, L Sesti, V L D A Pereira, E R D Nascimento
Mycoplasma gallisepticum causes coughing, ocular and nasal discharge, reduction in feed intake, lower and uneven growth, decline in egg production and quality, and increase in mortality. Among the attenuated vaccination strains, MGF can reduce clinical signs and lesions in layer hens, stimulate immune responses of cellular and humoral basis, act as an instrument of competitive exclusion in relation to field strains, and reduce the use of antimicrobials. This study aimed to investigate the effects of attenuated MG F-strain vaccination on egg quality in 3 groups of 30 hens each, being one control and 2 vaccinated...
October 12, 2016: Poultry Science
https://www.readbyqxmd.com/read/27633651/the-effects-of-a-multigrowth-factor-containing-cream-on-recovery-after-laser-treatment-a-double-blinded-randomized-split-face-controlled-study
#18
Sungsik Shin, Jung U Shin, Youngin Lee, Tae Gwang Kwon, Ju Hee Lee
BACKGROUND: Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor-containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient. AIMS: We performed a randomized controlled split-face study to assess the effects of a multigrowth factor (MGF)-containing cream on patients recovering from laser treatment. MATERIALS AND METHODS: Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF-containing cream or control cream...
September 16, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27625980/removal-of-fluoride-from-water-using-a-novel-sorbent-lanthanum-impregnated-bauxite
#19
C M Vivek Vardhan, M Srimurali
A novel sorbent, Lanthanum-Impregnated Bauxite (LIB), was prepared to remove fluoride from water. To understand the surface chemical composition and morphology, LIB was characterized using X-ray diffraction and scanning electron microscopy techniques. Experiments were performed to evaluate the sorption potential, dose of sorbent, kinetics, equilibrium sorption capacity, pH and influence of anions for defluoridation by LIB. Equilibrium isothermal studies were conducted to model the sorption and regeneration studies were carried out to evaluate the reusability of LIB...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27623796/intramuscular-injection-of-mechano-growth-factor-e-domain-peptide-regulated-expression-of-memory-related-sod-mir-134-and-mir-125b-3p-in-rat-hippocampus-under-simulated-weightlessness
#20
Hailong Chen, Ke Lv, Zhongquan Dai, Guohua Ji, Tingmei Wang, Yanli Wang, Yongliang Zhang, Guanghan Kan, Yinghui Li, Lina Qu
OBJECTIVE: To investigate the expression of memory-related antioxidant genes and miRNAs under simulated weightlessness and the regulation of mechano growth factor (MGF) E domain, the peptide preventing nerve damage. RESULTS: Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide...
December 2016: Biotechnology Letters
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