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L D S Machado, F F D Santos, C K Togashi, D L D C Abreu, J C Pimentel, L Sesti, V L D A Pereira, E R D Nascimento
Mycoplasma gallisepticum causes coughing, ocular and nasal discharge, reduction in feed intake, lower and uneven growth, decline in egg production and quality, and increase in mortality. Among the attenuated vaccination strains, MGF can reduce clinical signs and lesions in layer hens, stimulate immune responses of cellular and humoral basis, act as an instrument of competitive exclusion in relation to field strains, and reduce the use of antimicrobials. This study aimed to investigate the effects of attenuated MG F-strain vaccination on egg quality in 3 groups of 30 hens each, being one control and 2 vaccinated...
October 12, 2016: Poultry Science
Sungsik Shin, Jung U Shin, Youngin Lee, Tae Gwang Kwon, Ju Hee Lee
BACKGROUND: Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor-containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient. AIMS: We performed a randomized controlled split-face study to assess the effects of a multigrowth factor (MGF)-containing cream on patients recovering from laser treatment. MATERIALS AND METHODS: Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF-containing cream or control cream...
September 16, 2016: Journal of Cosmetic Dermatology
C M Vivek Vardhan, M Srimurali
A novel sorbent, Lanthanum-Impregnated Bauxite (LIB), was prepared to remove fluoride from water. To understand the surface chemical composition and morphology, LIB was characterized using X-ray diffraction and scanning electron microscopy techniques. Experiments were performed to evaluate the sorption potential, dose of sorbent, kinetics, equilibrium sorption capacity, pH and influence of anions for defluoridation by LIB. Equilibrium isothermal studies were conducted to model the sorption and regeneration studies were carried out to evaluate the reusability of LIB...
2016: SpringerPlus
Hailong Chen, Ke Lv, Zhongquan Dai, Guohua Ji, Tingmei Wang, Yanli Wang, Yongliang Zhang, Guanghan Kan, Yinghui Li, Lina Qu
OBJECTIVE: To investigate the expression of memory-related antioxidant genes and miRNAs under simulated weightlessness and the regulation of mechano growth factor (MGF) E domain, the peptide preventing nerve damage. RESULTS: Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after 14 days tail suspension to simulate weightlessness which was inhibited with intramuscular injection of E domain peptide...
September 13, 2016: Biotechnology Letters
E L Peters, C Offringa, D Kos, W J Van der Laarse, R T Jaspers
A major problem in chronic heart failure is the inability of hypertrophied cardiomyocytes to maintain the required power output. A Hill-type oxygen diffusion model predicts that oxygen supply is limiting in hypertrophied cardiomyocytes at maximal rates of oxygen consumption and that this limitation can be reduced by increasing the myoglobin (Mb) concentration. We explored how cardiac hypertrophy, oxidative capacity, and Mb expression in right ventricular cardiomyocytes are regulated at the transcriptional and translational levels in an early stage of experimental pulmonary hypertension, in order to identify targets to improve the oxygen supply/demand ratio...
October 2016: Pflügers Archiv: European Journal of Physiology
Timsi Rao, Rui Gao, Saeko Takada, Muthana Al Abo, Xiang Chen, Kylie J Walters, Yves Pommier, Hideki Aihara
Tyrosyl DNA phosphodiesterase 2 (TDP2) is a multifunctional protein implicated in DNA repair, signal transduction and transcriptional regulation. In its DNA repair role, TDP2 safeguards genome integrity by hydrolyzing 5'-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) cleavage complexes to allow error-free repair of DNA double-strand breaks, thereby conferring cellular resistance against Top2 poisons. TDP2 consists of a C-terminal catalytic domain responsible for its phosphodiesterase activity, and a functionally uncharacterized N-terminal region...
August 19, 2016: Nucleic Acids Research
Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Yolanda Marin-Zambrana, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloza
Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. Due to the limited success of available treatments, AD patients are in a tremendous need of new therapeutic options. Natural polyphenols, and concretely Mangifera indica Linn extract (MGF), have been reported to have antiinflammatory, antioxidant and antidiabetic activities. We have analyzed the role of MGF in central complications associated with T2D, after long-term treatment of db/db mice with MGF...
August 18, 2016: Brain Pathology
Ekaterina Vladimirovna Fomenko, Yuling Chi
The recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt this trend. Natural products have long been and continue to be an attractive source of nutritional and pharmacological therapeutics. One such natural product is mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera indica L. Reports on biological and pharmacological effects of MGF increased exponentially in recent years...
August 18, 2016: BioFactors
Umer Javed, Di He, Peilin Liu
The transmission of signals in a hybrid satellite-terrestrial system (HSTS) in the presence of co-channel interference (CCI) is considered in this study. Specifically, we examine the problem of amplify-and-forward (AF)-based relaying in a hybrid satellite-terrestrial link, where the relay node is operating in the presence of a dominant co-channel interferer. It is assumed that direct connection between a source node (satellite) and a destination node (terrestrial receiver) is not available due to masking by obstacles in the surrounding...
2016: Sensors
Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Irene Delgado-Olmos, Carlos Gamero-Carrasco, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloza
Alzheimer's disease (AD) is the most common cause of dementia; however, available treatments have had limited success. Therefore AD patients are in tremendous need of new pharmacological approaches that may delay or slow the progression of the disease. In addition to the classical neuropathological features, immunological and inflammatory processes are also involved in AD pathogenesis. Naturally occurring compounds, such as Mangifera indica Linn (MGF) extracts have previously been shown to significantly reduce peripheral inflammatory processes...
July 21, 2016: Molecular Neurobiology
A Carati, A M Maiocchi
We propose a new phenomenological law for the shape of the spectral lines in the infrared, which accounts for the exponential decay of the extinction coefficient in the high-frequency region, observed in many spectra. We apply this law to the measured infrared spectra of LiF, NaCl, and MgF<sub>2</sub>, finding good agreement over a wide range of frequencies.
June 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Gabriele Di Giammarco, Daniele Marinelli, Massimiliano Foschi, Michele Di Mauro
Transit-time flow measurement (TTFM) is a reliable method to check the graft function intraoperatively in coronary surgery. The given parameters are: Mean Graft Flow (MGF); Pulsatility Index (PI) and Insufficiency Ratio (%BF). Some cutoffs of these parameters have been identified as predictors for unfair 1-y clinical outcome: mean graft flow (MGF) less than 20 ml/min and high pulsatility index greater than 5. Other cutoffs have been found as related to postoperative angiography: MGF 15 ml/min or less and pulsatility index at least 3 (sensitivity 94%; specificity 61%); MGF less than 15 ml/min and pulsatility index greater than 3 for left coronary artery or pulsatility index greater than 5 for right coronary artery (sensitivity 96%; specificity 77%); MGF 15 ml/min or less and pulsatility index at least 5...
June 29, 2016: Journal of Cardiovascular Medicine
Joseph A M J L Janssen
Physical exercise may be vital to the maintenance of the endocrine system with aging and its helps to restore loss of activity of the endocrine system with aging. There is evidence that physical exercise induces activity of the growth hormone-insulin-like growth factor-1 axis and so produces anabolic effects in skeletal muscles. Mechano growth factor (MGF), a locally produced isoform of IGF-1, has been hypothesized to be important for the maintenance of skeletal muscles with aging. Short-term high-resistance exercise results in an increase of MGF mRNA in young but not in elderly subjects...
2016: Frontiers of Hormone Research
Bingyu Zhang, Qing Luo, Dongdong Kuang, Yang Ju, Guanbin Song
OBJECTIVES: To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon. RESULTS: A significantly increased Achilles functional index was found in the MGF-C25E-treated tendons relative to the saline-treated tendons. Macroscopic observation showed that the repair of MGF-C25E-treated (1000 ng/ml) tendons was superior to that of the saline-treated tendons. The mean value of the stiffness of the repaired tendons was significantly increased in the MGF-C25E-treated (1000 ng/ml) tendons relative to the saline-treated tendons...
October 2016: Biotechnology Letters
Juha P Ahtiainen, Juha J Hulmi, Maarit Lehti, William J Kraemer, Kai Nyman, Harri Selänne, Markku Alen, Jyrki Komulainen, Vuokko Kovanen, Antti A Mero, Anastassios Philippou, Eija K Laakkonen, Keijo Häkkinen
Insulin-like growth factor-I (IGF-I) and its splice variants Insulin-like growth factor-I isoform Ea (IGF-IEa) and mechano growth factor (MGF) may play an important role in muscular adaptations to resistance training (RT) that may be modulated by ageing. It has been suggested that IGF-I induces cellular responses via AKT8 virus oncogene cellular homolog (Akt) and Extracellular signal-regulated kinase (Erk) signalling pathways. Therefore, resistance exercise-induced changes in skeletal muscle IGF-IEa and MGF messenger ribonucleic acid (mRNA), and MGF, Erk1/2, Akt and p70S6K protein expression were investigated before and after 21 weeks of RT in younger (YM, 20-34 yrs...
November 2016: European Journal of Sport Science
Kazuya Yamada, Akihiko Uchiyama, Akihito Uehara, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi, Mark C Udey, Osamu Ishikawa, Sei-Ichiro Motegi
Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas that express it. We found that mouse bone marrow-derived mesenchymal stromal cells (MSC) expressed a substantial amount of MFG-E8. To assess its expression from this cell type, we implanted melanoma cells and MSC derived from wild type (WT) or MFG-E8 deficient [knockout (KO)] into mice and monitored tumor growth...
July 15, 2016: Cancer Research
Vivian O'Donnell, Lauren G Holinka, Brenton Sanford, Peter W Krug, Jolene Carlson, Juan M Pacheco, Bo Reese, Guillermo R Risatti, Douglas P Gladue, Manuel V Borca
African swine fever virus (ASFV) produces a contagious disease of domestic pigs that results in severe economic consequences to the swine industry. Control of the disease has been hampered by the unavailability of vaccines. We recently reported the development of two experimental vaccine strains (ASFV-G-Δ9GL and ASFV-G-ΔMGF) based on the attenuation of the highly virulent and epidemiologically relevant Georgia2007 isolate. Deletion of the 9GL gene or six genes of the MGF360/505 group produced two attenuated ASFV strains which were able to confer protection to animals when challenged with the virulent parental virus...
August 2, 2016: Virus Research
Ivan S Grudinin, Kamjou Mansour, Nan Yu
We study crystalline fluoride microresonators for mid-infrared (mid-IR) applications. Whispering gallery mode resonators were fabricated with BaF<sub>2</sub>, CaF<sub>2</sub>, and MgF<sub>2</sub> crystals. The quality factors were measured at wavelengths of 1.56 and 4.58 μm. The impacts of post-fabrication processing, impurities, and surface water are highlighted. The mid-IR optical losses due to multiphoton absorption are measured. It is found that MgF<sub>2</sub> resonators have a room temperature Q-factor of 8...
May 15, 2016: Optics Letters
Xiaoting Tian, Zhou Xu, Zhixiong Li, Yuanjie Ma, Shan Lian, Xiaozhen Guo, Pei Hu, Yu Gao, Chenggang Huang
The poor bioavailability of mangiferin (MGF) is a major obstacle on its further development. Aimed to illustrate the underlying mechanism and improve its poor exposure, the compared PK profiles of MGF and norathyriol (NTR) after different MGF preparation were performed: pure MGF, the Rhizoma Anemarrhenae (Zhi-mu) decoction, MGF, and timosaponin B2 (TB-2) combination. Furthermore, the potential contributing factors, including uridine diphosphoglucuronosyltransferase (UGT), cytochrome P450 (CYP450), P-gp, and enterobacterial were investigated by comparing the PK profiles with and without the corresponding inhibitors or in different rat models...
May 6, 2016: BioFactors
R M Bussell, R Nichol, K J Toumba
AIM: To provide a comprehensive report of fluoride concentration in UK infant milks and estimate their contribution to daily fluoride intake. METHODS: A total of 60 formula milk products available commercially or within a hospital environment were analysed, along with eight pasteurised cow's milk samples. Formula milk products requiring preparation were reconstituted with fresh Leeds tap water (0.02 ppmF). Fluoride concentration was measured for all products directly using an ion selective electrode after addition of low-level total ionic strength adjustment buffer...
June 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
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