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Hemlata Bhatia, Erik Read, Cyrus Agarabi, Kurt Brorson, Scott Lute, Seongkyu Yoon
A unique "design space (DSp) exploration strategy," defined as a function of four key scenarios, was successfully integrated and validated to enhance the DSp building exercise, by increasing the accuracy of analyses and interpretation of processed data. The four key scenarios, defining the strategy, were based on cumulative analyses of individual models developed for the Critical Quality Attributes (23 Glycan Profiles) considered for the study. The analyses of the CQA estimates and model performances were interpreted as (1) Inside Specification/Significant Model (2) Inside Specification/Non-significant Model (3) Outside Specification/Significant Model (4) Outside Specification/Non-significant Model...
October 15, 2016: International Journal of Pharmaceutics
Shoko Furuta, Rika Kuwahara, Eri Hiraki, Koichiro Ohnuki, Shinobu Yasuo, Kuniyoshi Shimizu
Hericium erinaceus (HE), an edible mushroom, has been used as a herbal medicine in several Asian countries since ancient times. HE has potential as a medicine for the treatment and prevention of dementia, a disorder closely linked with circadian rhythm. This study investigated the effects of the intake of HE extracts on behavioral rhythm, photosensitivity of the circadian clock, and clock gene mRNA expression in the suprachiasmatic nucleus (SCN), a central clock, in mice. Although the HE ethanol extract only affected the offset time of activity, the HE water extract advanced the sleep-wake cycle without affecting the free-running period, photosensitivity, or the clock gene mRNA expression in SCN...
2016: Biomedical Research
Mathieu Amand, Charlotte Erpicum, Christine Gilles, Agnès Noël, Souad Rahmouni
Therapeutic perspectives targeting angiogenesis in cancer stimulated an intense investigation of the mechanisms triggering and governing angiogenic processes. Several publications have highlighted the importance of typical dual-specificity phosphatases (DSPs) or MKPs in endothelial cells and their role in controlling different biological functions implicated in angiogenesis such as migration, proliferation, apoptosis, tubulogenesis, and cell adhesion. However, among atypical DSPs, the only one investigated in angiogenesis was DUSP3...
2016: Methods in Molecular Biology
Michael H Smolensky, Ramon C Hermida, Alain Reinberg, Linda Sackett-Lundeen, Francesco Portaluppi
Biological processes are organized in time as innate rhythms defined by the period (τ), phase (peak [Φ] and trough time), amplitude (A, peak-trough difference) and mean level. The human time structure in its entirety is comprised of ultradian (τ < 20 h), circadian (20 h > τ < 28 h) and infradian (τ > 28 h) bioperiodicities. The circadian time structure (CTS) of human beings, which is more complicated than in lower animals, is orchestrated and staged by a brain central multioscillator system that includes a prominent pacemaker - the suprachiasmatic nuclei of the hypothalamus...
2016: Chronobiology International
Fumiyuki Goto, Miki Arai, Mitusru Kitamura, Tomoko Otomo, Ryoto Nagai, Shuujiro Minami, Takanobu Shimada, Tatsuo Matsunaga, Kouichi Tsunoda, Masato Fujii
INTRODUCTION: The aim of this case report was to investigate the relationship between sleep disorders and audio vestibular symptoms. CASE REPORT: A case of undiagnosed sleep disorder, presenting as a temporary auditory processing difficulty, is presented. The disorder was initially treated as sudden deafness with dizziness. A 23-year-old male patient complained of acute hearing disturbance despite normal results on pure tone audiometry. The patient was initially administered a steroid injection in the hospital...
March 2016: Iranian Journal of Otorhinolaryngology
E Boni, L Bassi, A Dallai, F Guidi, V Meacci, A Ramalli, S Ricci, P Tortoli
Open scanners offer an increasing support to the ultrasound researchers who are involved in the experimental test of novel methods. Each system presents specific performance in terms of number of channels, flexibility, processing power, data storage capability and overall dimensions. This paper reports the design criteria and hardware/software implementation details of a new 256-channel ULtrasound Advanced Open Platform (ULA-OP 256). This system is organized in a modular architecture including multiple front-end boards, interconnected by a high-speed (80 Gbit/s) ring, capable of finely controlling all transmit and receive signals...
May 11, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Najaf Amin, Karla V Allebrandt, Ashley van der Spek, Bertram Müller-Myhsok, Karin Hek, Maris Teder-Laving, Caroline Hayward, Tõnu Esko, Josine G van Mill, Hamdi Mbarek, Nathaniel F Watson, Scott A Melville, Fabiola M Del Greco, Enda M Byrne, Edwin Oole, Ivana Kolcic, Ting-Hsu Chen, Daniel S Evans, Josef Coresh, Nicole Vogelzangs, Juha Karjalainen, Gonneke Willemsen, Sina A Gharib, Lina Zgaga, Evelin Mihailov, Katie L Stone, Harry Campbell, Rutger Ww Brouwer, Ayse Demirkan, Aaron Isaacs, Zoran Dogas, Kristin D Marciante, Susan Campbell, Fran Borovecki, Annemarie I Luik, Man Li, Jouke Jan Hottenga, Jennifer E Huffman, Mirjam Cgn van den Hout, Steven R Cummings, Yurii S Aulchenko, Philip R Gehrman, André G Uitterlinden, Heinz-Erich Wichmann, Martina Müller-Nurasyid, Rudolf Sn Fehrmann, Grant W Montgomery, Albert Hofman, Wen Hong Linda Kao, Ben A Oostra, Alan F Wright, Jacqueline M Vink, James F Wilson, Peter P Pramstaller, Andrew A Hicks, Ozren Polasek, Naresh M Punjabi, Susan Redline, Bruce M Psaty, Andrew C Heath, Martha Merrow, Gregory J Tranah, Daniel J Gottlieb, Dorret I Boomsma, Nicholas G Martin, Igor Rudan, Henning Tiemeier, Wilfred Fj van IJcken, Brenda W Penninx, Andres Metspalu, Thomas Meitinger, Lude Franke, Till Roenneberg, Cornelia M van Duijn
Time to fall asleep (sleep latency) is a major determinant of sleep quality. Chronic, long sleep latency is a major characteristic of sleep-onset insomnia and/or delayed sleep phase syndrome. In this study we aimed to discover common polymorphisms that contribute to the genetics of sleep latency. We performed a meta-analysis of genome-wide association studies (GWAS) including 2 572 737 single nucleotide polymorphisms (SNPs) established in seven European cohorts including 4242 individuals. We found a cluster of three highly correlated variants (rs9900428, rs9907432 and rs7211029) in the RNA-binding protein fox-1 homolog 3 gene (RBFOX3) associated with sleep latency (P-values=5...
October 2016: European Journal of Human Genetics: EJHG
T I Bron, D Bijlenga, J J S Kooij, S W N Vogel, D Wynchank, A T F Beekman, B W J H Penninx
BACKGROUND: Comorbid ADHD symptoms may partly account for circadian rhythm disturbances in depression and anxiety disorders. METHODS: Self-reported sleep characteristics of 2090 participants in the Netherlands Study of Depression and Anxiety were assessed using the Munich Chronotype Questionnaire. We defined 3 groups: healthy controls (HC), persons with lifetime depression and/or anxiety disorders (LDA), and those with both LDA and high ADHD symptoms (LDA+ADHD), using the Conner's Adult ADHD Rating Scale...
August 2016: Journal of Affective Disorders
Irvin Janjua, Ran D Goldman
QUESTION: A mother brought her 12-year-old son into my office because she is concerned that he has difficulty falling asleep almost every night. Her job involves shift work and she uses melatonin herself to help her fall asleep. She asked if her son could take melatonin. What are the recommendations and considerations for using melatonin in otherwise healthy children and adolescents? ANSWER: Insomnia is reported in up to a quarter of healthy children and in three-quarters of children with neurodevelopmental and psychiatric conditions, resulting in negative consequences...
April 2016: Canadian Family Physician Médecin de Famille Canadien
Peng Yin, Xiaoqi Feng, Thomas Astell-Burt, Andrew Page, Jiangmei Liu, Yunning Liu, Shiwei Liu, Lijun Wang, Limin Wang, Maigeng Zhou
OBJECTIVES: We aimed to explore the temporal trends and geographic variations in dementia mortality in China. MATERIALS AND METHODS: Annual dementia mortality counts (years 2006 to 2012) in 161 counties and districts (Disease Surveillance Points, DSP) were extracted from the nationally representative China Mortality Surveillance System and stratified by 5-year age group (aged >65), sex, and time. These counts were linked to annually adjusted denominator populations...
March 18, 2016: Alzheimer Disease and Associated Disorders
Alka Shankar, Nisha Agrawal, Manisha Sharma, Amita Pandey, Margarita Girdhar K Pandey
Reversible protein phosphorylation is a crucial regulatory mechanism that controls many biological processes in eukaryotes. In plants, phosphorylation events primarily occur on serine (Ser) and threonine (Thr) residues, while in certain cases, it was also discovered on tyrosine (Tyr) residues. In contrary to plants, extensive reports on Tyr phosphorylation regulating a large numbers of biological processes exist in animals. Despite of such prodigious function in animals, Tyr phosphorylation is a least studied mechanism of protein regulation in plants...
August 2015: Current Genomics
Qin He, Yeji Chen, Dan Dai, Wei Xu, Xiuya Xing, Zhirong Liu
OBJECTIVE: To analyze the demographic characteristics and the death causes of the residents in Anhui province, and provide evidence for the disease prevention and control. METHODS: Using descriptive epidemiological analysis, the demographic characteristics and death data of the national disease surveillance points (DSPs) in Anhui province in 2013 were analyed by areas. RESULTS: The aging of the population was observed in all the areas in Anhui, which was most obvious in Jianghuai, followed by Wannan and Huaibei...
September 2015: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Anna Ashworth, Catherine M Hill, Annette Karmiloff-Smith, Dagmara Dimitriou
Sleep plays an active role in memory consolidation. Because children with Down syndrome (DS) and Williams syndrome (WS) experience significant problems with sleep and also with learning, we predicted that sleep-dependent memory consolidation would be impaired in these children when compared to typically developing (TD) children. This is the first study to provide a cross-syndrome comparison of sleep-dependent learning in school-aged children. Children with DS (n = 20) and WS (n = 22) and TD children (n = 33) were trained on the novel Animal Names task where they were taught pseudo-words as the personal names of ten farm and domestic animals, e...
December 22, 2015: Developmental Science
Mari Hysing, Astri J Lundervold, Maj-Britt Posserud, Børge Sivertsen
Sleep problems and symptoms of ADHD are common in adolescence, but detailed epidemiological assessment of their association is lacking. Using data from a recent population-based study, 9,846 adolescents aged 16 to 19 provided detailed information on sleep and symptoms of ADHD. Results confirmed a large overlap between self-reported symptoms of ADHD and all sleep variables studied. Symptoms of ADHD were linked to shorter sleep duration, longer sleep latency, and nocturnal wake time, as well as larger sleep deficiency...
September 2016: Behavioral Sleep Medicine
Rachel A Mumford, Louise V Mahon, Simon Jones, Brian Bigger, Maria Canal, Dougal Julian Hare
BACKGROUND: Sleep disturbance is part of the behavioural phenotype of the rare genetic condition mucopolysaccharidosis (MPS) type III. A growing body of evidence suggests that underlying disturbance in circadian rhythm functioning may explain sleep problems within the MPS III population. METHODS: Actigraphic data were recorded in eight children with MPS III over 7-10 days and compared to age-matched typically developing controls. Parameters of circadian rhythmicity and activity levels across a 24-h period were analysed...
2015: Journal of Neurodevelopmental Disorders
Binru Wang, Xianrong Xu, Gengtian Liang, Yingying Zhang, Li Liu, Juan Zhang
OBJECTIVE: To research the serum levels of BDNF, H2S and S-100β as metabolic product of hippocampus and cerebral cortex in moderate to severe obstructive sleep apnea hypopnea syndrome(OSAHS) patients before and after surgery, and to analyze their correlations with cognitive impairment. METHOD: Forty-four randomly selected diagnosed OSAHS patients were divided into two groups according to Montreal Cognitive Assessment (MoCA), 19 cases in cognitively normal group and 25 cases in cognitive dysfunction group...
April 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Pierre Alexis Geoffroy, Bruno Etain, Jean-Arthur Micoulaud Franchi, Frank Bellivier, Philipp Ritter
Bipolar disorders (BD) present with abnormalities of circadian rhythmicity and sleep homeostasis, even during phases of remission. These abnormalities are linked to the underlying neurobiology of genetic susceptibility to BD. Melatonin is a pineal gland secreted neurohormone that induces circadian-related and sleep-related responses. Exogenous melatonin has demonstrated efficacy in treating primary insomnia, delayed sleep phase disorder, improving sleep parameters and overall sleep quality, and some psychiatric disorders like autistic spectrum disorders...
2015: Current Pharmaceutical Design
Maria Gardani, Eleni Morfiri, Allan Thomson, Brian O'Neill, Thomas M McMillan
OBJECTIVE: To explore the presence and types of sleep disorders in chronic patients with severe traumatic brain injury (TBI) undergoing inpatient rehabilitation using formal diagnostic criteria based on the International Classification of Sleep Disorders, 2nd edition. DESIGN: Cross-sectional study. SETTING: Inpatient brain injury rehabilitation units. PARTICIPANTS: Chronic inpatients with severe TBI (N=30) were evaluated during rehabilitation...
September 2015: Archives of Physical Medicine and Rehabilitation
Ryuichiro Yamamoto, Yoshitaka Kaneita, Yoneatsu Osaki, Hideyuki Kanda, Kenji Suzuki, Susumu Higuchi, Maki Ikeda, Shuji Kondo, Takeshi Munezawa, Takashi Ohida
BACKGROUND AND AIM: No nationally representative survey of irritable bowel syndrome (IBS) among adolescents has ever been performed in Japan. In the present study, we aimed to clarify the prevalence of IBS among Japanese adolescents and the factors associated with it. METHODS: The items related to the diagnostic criteria for IBS based on the Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders were included in a cross-sectional nationwide survey of "alcohol consumption and smoking habits among junior and senior high school students...
September 2015: Journal of Gastroenterology and Hepatology
Shu-qun Shi, Terry Jo Bichell, Rebecca A Ihrie, Carl Hirschie Johnson
BACKGROUND: The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman syndrome (AS) is a disorder arising from a deletion or mutation of the maternal Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep disorders such as short sleep duration and increased sleep onset latency are very common in AS. RESULTS: We found a unique link between neuronal imprinting of Ube3a and circadian rhythms in two mouse models of AS, including enfeebled circadian activity behavior and slowed molecular rhythms in ex vivo brain tissues...
March 2, 2015: Current Biology: CB
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