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https://www.readbyqxmd.com/read/29760344/is-there-any-clinical-significance-of-the-acute-antral-lesion-size-after-pulmonary-vein-isolation-using-different-balloon-technologies-or-ablation-energy
#1
Tolga Aksu, Tümer Erdem Guler, Serdar Bozyel, Kazım Serhan Ozcan, Kivanc Yalin
No abstract text is available yet for this article.
May 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29755640/melatonin-and-tumeric-ameliorate-aging-induced-changes-implication-of-immunoglobulins-cytokines-dj-1-nrf2-and-apoptosis-regulation
#2
Ismail Ahmed Ismail, Hanan A El-Bakry, Safaa S Soliman
Aging is associated with several biological, physiological, cellular and histological changes. In the present study, we investigated the effect of aging on different signaling pathways, including antioxidant system, apoptosis and immune status. Several natural products were used to ameliorate and block aging-related changes. Melatonin and turmeric have been known to ameliorate and decrease aging-related changes. However, the exact mechanism(s) of their action is not fully understood. In the present study, we tried to uncover the regulatory mechanism(s) by which melatonin and turmeric work against aging...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29747146/verteporfin-mediated-sequence-dependent-combination-therapy-against-ovarian-cancer-cell-line
#3
S Sibel Erdem, Vildan Akgul Obeidin, Turkan Yigitbasi, S Serranur Tumer, Pakize Yigit
Ovarian Cancer is one of the deadliest gynecological cancer showing high resistance to chemotherapy. Non-overlapping and synergistic combination therapies are the best option to overcome this multi-pathological silent disease. Cationic peptides (CPs) with high targeting feature and ability to pass through cell membrane induce apoptosis via disruption of cancer cell membrane. Photodynamic Therapy (PDT) is a noninvasive clinically approved treatment modality combining light activated photosensitizer, light and oxygen...
May 1, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29746437/hematologic-findings-of-inherited-metabolic-disease-they-are-more-than-expected
#4
Ertan Sal, Idil Yenicesu, Ilyas Okur, Zuhre Kaya, Fatih S Ezgu, Ulker Kocak, Leyla Tumer, Turkiz Gursel, Alev Hasanoglu
Inherited metabolic diseases are pathologic conditions that generally develop as a result of impairment of the production or breakdown of protein, carbohydrate, and fatty acids. Early determination of hematological findings has a positive effect on the prognosis of metabolic diseases. Three hundred eighteen patients who were being followed-up within the previous 6 months at Department of Pediatric Nutrition and Metabolism, Gazi University, Turkey, were included in the study. The hematological findings were classified under 7 main groups: anemia of chronic disease, iron deficiency anemia, vitamin B12 deficiency anemia, hemophagocytosis, leukocytosis, and thrombocytosis...
May 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29729383/ameliorative-potential-of-lavandula-stoechas-in-metabolic-syndrome-via-multitarget-interactions
#5
S S Kulabas, H Ipek, A R Tufekci, S Arslan, I Demirtas, R Ekren, U Sezerman, T B Tumer
ETHNOPHARMACOLOGICAL IMPORTANCE: Decoction and infusion prepared from aerial parts of Lavandula stoechas L. (L. stoechas) have been traditionally used as remedy against several components of metabolic syndrome (MetS) and associated disorders including type II diabetes and cardiovascular diseases by Anatolian people. AIM OF THE STUDY: The aim is to elucidate the potential ameliorative effects of L. stoechas aqueous extracts on insulin resistance and inflammation models through multitarget in vitro approaches and also to elucidate mechanism of action by analyzing transcriptional and metabolic responses...
May 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29669352/macrophage-migration-inhibitory-factor-173gc-variant-might-increase-the-risk-of-beh%C3%A3-et-s-disease
#6
Ayse Feyda Nursal, Serbulent Yigit, Ercan Tural, Goknur Kalkan, Mehmet Kemal Tumer, Akin Tekcan
OBJECTIVE: The aim of the present study was to investigate any possible association between macrophage migration inhibitory factor (MIF) -173GC variant and Behçet's Disease (BD) in a group of Turkish patients. SUBJECTS AND METHODS: In this case-control study performed in a university hospital, 111 patients with BD and 100 healthy age-matched controls participated. Genomic DNA was extracted from peripheral lymphocytes. MIF -173GC variant was genotyped using (PCR-RFLP)...
April 18, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29603867/delineating-the-psychiatric-and-behavioral-phenotype-of-recurrent-2q13-deletions-and-duplications
#7
Kate Wolfe, Andrew McQuillin, Viola Alesi, Elise Boudry Labis, Peter Cutajar, Bruno Dallapiccola, Maria Lisa Dentici, Anne Dieux-Coeslier, Benedicte Duban-Bedu, Tina Duelund Hjortshøj, Himanshu Goel, Sara Loddo, Deborah Morrogh, Anne-Laure Mosca-Boidron, Antonio Novelli, Laurence Olivier-Faivre, Jennifer Parker, Michael J Parker, Christine Patch, Anna L Pelling, Thomas Smol, Zeynep Tümer, Olivier Vanakker, Arie van Haeringen, Clémence Vanlerberghe, Andre Strydom, David Skuse, Nick Bass
Recurrent deletions and duplications at the 2q13 locus have been associated with developmental delay (DD) and dysmorphisms. We aimed to undertake detailed clinical characterization of individuals with 2q13 copy number variations (CNVs), with a focus on behavioral and psychiatric phenotypes. Participants were recruited via the Unique chromosomal disorder support group, U.K. National Health Service Regional Genetics Centres, and the DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) database...
March 31, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29549928/catheter-ablation-of-bradyarrhythmia-from-the-beginning-to-the-future
#8
REVIEW
Tolga Aksu, Tumer Erdem Guler, Kivanc Yalin, Ferit Onur Mutluer, Kazim Serhan Ozcan, Leonardo Calò
Enhanced parasympathetic tone may cause sinus bradycardia or pauses, transient or permanent atrioventricular block, with resultant vasovagal syncope. A substantial portion of these patients may be highly symptomatic and refractory to the conventional therapies and may require cardiac pacemaker implantation. Cardioneuroablation is a little known technique for management of patients with excessive vagal activation based on radiofrequency catheter ablation of main parasympathetic autonomic ganglia around the heart...
March 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29473178/pas-c-platelets-contain-less-plasma-protein-lower-anti-a-and-anti-b-titers-and-decreased-hla-antibody-specificities-compared-to-plasma-platelets
#9
Stuart P Weisberg, Beth H Shaz, Gizem Tumer, Chris C Silliman, Marguerite R Kelher, Claudia S Cohn
BACKGROUND: Platelets (PLTs) collected and stored in PLT additive solution Intersol (PAS-C) are presumed to reduce recipient exposure to donor plasma components; however, the effects of PAS-C on PLT supernatant composition are poorly defined. Therefore, we compared the total protein concentration, isohemagglutinin titers, and HLA antibodies in supernatants of PAS-C PLTs to plasma PLTs. STUDY DESIGN AND METHODS: Apheresis PLTs from group O blood donors were collected into either 100% donor plasma (n = 50) or a mixture of 65% PAS-C/35% donor plasma (n = 50)...
April 2018: Transfusion
https://www.readbyqxmd.com/read/29468807/fatigue-and-quasi-static-mechanical-behavior-of-bio-degradable-porous-biomaterials-based-on-magnesium-alloys
#10
R Hedayati, S M Ahmadi, K Lietaert, N Tümer, Y Li, S Amin Yavari, A A Zadpoor
Magnesium and its alloys have the intrinsic capability of degrading over time in vivo without leaving toxic degradation products. They are therefore suitable for use as biodegradable scaffolds that are replaced by the regenerated tissues. One of the main concerns for such applications, particularly in load-bearing areas, is the sufficient mechanical integrity of the scaffold before sufficient volumes of de novo tissue is generated. In the majority of the previous studies on the effects of biodegradation on the mechanical properties of porous biomaterials, the change in the elastic modulus has been studied...
February 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29377879/expert-consensus-document-clinical-and-molecular-diagnosis-screening-and-management-of-beckwith-wiedemann-syndrome-an-international-consensus-statement
#11
REVIEW
Frédéric Brioude, Jennifer M Kalish, Alessandro Mussa, Alison C Foster, Jet Bliek, Giovanni Battista Ferrero, Susanne E Boonen, Trevor Cole, Robert Baker, Monica Bertoletti, Guido Cocchi, Carole Coze, Maurizio De Pellegrin, Khalid Hussain, Abdulla Ibrahim, Mark D Kilby, Malgorzata Krajewska-Walasek, Christian P Kratz, Edmund J Ladusans, Pablo Lapunzina, Yves Le Bouc, Saskia M Maas, Fiona Macdonald, Katrin Õunap, Licia Peruzzi, Sylvie Rossignol, Silvia Russo, Caroleen Shipster, Agata Skórka, Katrina Tatton-Brown, Jair Tenorio, Chiara Tortora, Karen Grønskov, Irène Netchine, Raoul C Hennekam, Dirk Prawitt, Zeynep Tümer, Thomas Eggermann, Deborah J G Mackay, Andrea Riccio, Eamonn R Maher
Beckwith-Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth, macroglossia, abdominal wall defects, neonatal hypoglycaemia, lateralized overgrowth and predisposition to embryonal tumours. Delineation of the molecular defects within the imprinted 11p15.5 region can predict familial recurrence risks and the risk (and type) of embryonal tumour. Despite recent advances in knowledge, there is marked heterogeneity in clinical diagnostic criteria and care...
April 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29299989/curcuminoids-plus-piperine-modulate-adipokines-in-type-2-diabetes-mellitus
#12
Amirhossein Sahebkar, Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Stephen L Atkin, Muhammed Majeed
OBJECTIVE: Curcumin is a naturally occurring polyphenol derived from tumeric that has been reported to have anti-inflammatory properties with effects on adipokine and ghrelin levels. Adiponectin, leptin and ghrelin modulate energy homeostasis but each have modulatory effects on inflammatory cytokines and the immune system. Therefore this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin. METHODS: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period...
January 3, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29250858/structural-and-sequence-variants-in-patients-with-silver-russell-syndrome-or-similar-features-curation-of-a-disease-database
#13
Zeynep Tümer, Julia Angélica López-Hernández, Irène Netchine, Miriam Elbracht, Karen Grønskov, Lene Bjerring Gede, Jana Sachwitz, Johan T den Dunnen, Thomas Eggermann
Silver-Russell syndrome (SRS) is a clinically and molecularly heterogeneous disorder involving prenatal and postnatal growth retardation, and the term SRS-like is broadly used to describe individuals with clinical features resembling SRS. The main molecular subgroups are loss of methylation of the distal imprinting control region (H19/IGF2:IG-DMR) on 11p15.5 (50%) and maternal uniparental disomy of chromosome 7 (5%-10%). Through a comprehensive literature search, we identified 91 patients/families with various structural and small sequence variants, which were suggested as additional molecular defects leading to SRS/SRS-like phenotypes...
March 2018: Human Mutation
https://www.readbyqxmd.com/read/29242158/additively-manufactured-biodegradable-porous-magnesium
#14
Y Li, J Zhou, P Pavanram, M A Leeflang, L I Fockaert, B Pouran, N Tümer, K-U Schröder, J M C Mol, H Weinans, H Jahr, A A Zadpoor
An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly challenging. Here we present topologically ordered porous magnesium (WE43) scaffolds based on the diamond unit cell that were fabricated by selective laser melting (SLM) and satisfy all the requirements...
February 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29216723/effect-of-aquaporin-1-and-4-on-masticatory-muscles-degeneration-as-a-result-of-aging
#15
M K Tumer, M Demir, M Cicek
OBJECTIVE: The changes in the mouth structures due to aging cause some structural and functional changes by affecting masticatory muscles over time. The aim of this study was to evaluate the aging-related histopathologic changes and immunohistochemically assessed aquaporin 1 and 4 expressions on masseter and temporal muscles. MATERIAL AND METHODS: 14 Balb/c white mice (50-80 g) were used in this study. Group I consisted of young animals (2-month-individuals) (n = 7) and Group II consisted of older animals (18-month-old) (n = 7)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29208256/combined-cryoballoon-and-radiofrequency-ablation-versus-radiofrequency-ablation-alone-for-long-standing-persistent-atrial-fibrillation
#16
COMPARATIVE STUDY
Tümer Erdem Guler, Tolga Aksu, Kivanc Yalin, Sukriye Ebru Golcuk, Ferit Onur Mutluer, Serdar Bozyel
BACKGROUND: To achieve sinus rhythm, ablation of long-standing persistent atrial fibrillation (LSPAF) usually requires substrate modification in addition to pulmonary vein isolation (PVI). In the present article, we aimed to compare clinical and substrate modification effects of 2 distinct PVI strategies during stepwise ablation in patients with LSPAF: (1) Combined approach: cryoballoon (CB) for PVI and radiofrequency (RF) ablation for substrate modification and (2) RF-only approach: RF ablation for both PVI and substrate modification...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29138218/lecture-attendance-improves-success-in-medical-physiology
#17
Enver Ahmet Demir, Okan Tutuk, Hatice Dogan, Duygu Egeli, Cemil Tumer
The educators have underlined the importance of lecture attendance for decades. Nowadays, students have ample online educational sources, which began a debate on the necessity of in-class lectures. In the present study, we investigated the influence of lecture attendance on the exam success. To this aim, we adopted a novel approach and matched second-year medicine students' answers in three interim exams with the lectures related to those questions. Thereby, we were able to evaluate if attending lectures increases the chance of giving a correct answer to the exam question generated from the attended lecture...
December 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/29131966/activation-of-the-central-melanocortin-system-in-rats-persistently-reduces-body-and-fat-mass-independently-of-caloric-reduction
#18
Isabelle Côté, Sara M Green, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
Recent evidence indicate that melanotan II (MTII) reduces body mass independently of caloric reduction. Because MTII induces a transient hypophagia, caloric reduction is still considered a primary mechanism for MTII-mediated body mass loss. To examine the contribution of caloric reduction to long-term body mass loss in response to MTII, we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison with a group of animals that were pair-fed (PF) to the MTII group. Food intake and body mass were recorded daily, and body composition was assessed biweekly...
March 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29127065/fatigue-performance-of-additively-manufactured-meta-biomaterials-the-effects-of-topology-and-material-type
#19
S M Ahmadi, R Hedayati, Y Li, K Lietaert, N Tümer, A Fatemi, C D Rans, B Pouran, H Weinans, A A Zadpoor
Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is, however, not clear to what extent the material type is important in determining the fatigue behavior of such biomaterials. We therefore aimed to determine the isolated and modulated effects of topological design and material type on the fatigue response of metallic meta-biomaterials fabricated with selective laser melting...
January 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29125933/can-use-of-rigid-fixation-after-consolidation-increase-stability-in-cleft-patients-following-distraction-osteogenesis
#20
Reza Tabrizi, Kemal Tumer, Shervin Shafiei, Ashkan Rashad
PURPOSE: The stability of distraction osteogenesis (DO) is an important issue in maxillary advancement for patients with cleft lip and palate (CLP). The aim of this study was to evaluate postoperative stability in patients with and without internal fixation after removing maxillary distraction devices. MATERIALS AND METHODS: This randomized clinical trial assessed patients with CLP who needed maxillary advancement greater than 6 mm; they were randomly assigned to 1 of 2 groups...
October 16, 2017: Journal of Oral and Maxillofacial Surgery
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