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https://www.readbyqxmd.com/read/29094243/alleviation-of-cardiac-damage-by-dietary-fenugreek-trigonella-foenum-graecum-seeds-is-potentiated-by-onion-allium-cepa-in-experimental-diabetic-rats-via-blocking-renin-angiotensin-system
#1
Seetur R Pradeep, Krishnapura Srinivasan
Hyperglycemia is one of the metabolic and homeostatic abnormalities that increase the cardiovascular mortality in diabetic patients by increased oxidative stress. We have recently reported amelioration of oxidative stress in cardiac tissue by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats. The mechanistic aspects of the cardio-protective influence of dietary fenugreek seeds (10%) and onion (3% powder) both individually and in combination on hyperglycemia-mediated cardiac damage was further investigated in this study on streptozotocin-induced diabetic rats...
November 1, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29068452/alleviation-of-oxidative-stress-mediated-nephropathy-by-dietary-fenugreek-trigonella-foenum-graecum-seeds-and-onion-allium-cepa-in-streptozotocin-induced-diabetic-rats
#2
Seetur R Pradeep, Krishnapura Srinivasan
Oxidative stress plays a major role in the progression of diabetes and the pathogenesis of diabetic nephropathy. In this study, the beneficial influence of dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) on oxidative stress-mediated renal injury was evaluated in streptozotocin-induced diabetic rats. Diabetes was induced in adult Wistar rats by the administration of streptozotocin (i.p. 45 mg kg(-1)). Dietary interventions were made with 10% fenugreek seeds or 3% onion (freeze-dried) or their combination for 6 weeks...
October 25, 2017: Food & Function
https://www.readbyqxmd.com/read/29066172/effects-of-nanosized-titanium-dioxide-on-the-photosynthetic-metabolism-of-fenugreek-trigonella-foenum-graecum-l
#3
Takwa Missaoui, Moêz Smiri, Hajer Chmingui, Amor Hafiane
The potential toxicity of nanoparticles in plants is scarce and contradictory. Despite the diversity of research efforts, a detailed explanation of the TiO2NPS effects in plant photosynthesis is still missing. The present work gives a new approach to examine the impact of the TiO2NPs on crop production (development and photosynthesis) and plant protection (tolerance and defense systems) in fenugreek (Trigonella foenum graecum L.). Seedlings were assessed in greenhouse trials to estimate the influence of TiO2NPs on physiological characters for 16 days...
October 21, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28986580/fenugreek-supplementation-during-high-fat-feeding-improves-specific-markers-of-metabolic-health
#4
Eric J Knott, Allison J Richard, Randall L Mynatt, David Ribnicky, Jacqueline M Stephens, Annadora Bruce-Keller
To assess the metabolically beneficial effects of fenugreek (Trigonella foenum-graecum), C57BL/6J mice were fed a low- or high-fat diet for 16 weeks with or without 2% (w/w) fenugreek supplementation. Body weight, body composition, energy expenditure, food intake, and insulin/glucose tolerance were measured regularly, and tissues were collected for histological and biochemical analysis after 16 weeks of diet exposure. Fenugreek did not alter body weight, fat mass, or food intake in either group, but did transiently improve glucose tolerance in high fat-fed mice...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28975089/traditional-uses-of-medicinal-plants-to-prevent-and-treat-diabetes-an-updated-review-of-ethnobotanical-studies-in-iran
#5
REVIEW
Majid Asadi-Samani, Mohammad-Taghi Moradi, Leila Mahmoodnia, Shahla Alaei, Fatemeh Asadi-Samani, Tahra Luther
BACKGROUND: Obesity and physical inactivity are currently on the rise due to industrialization of the communities, which has recently led to increased incidence of different diseases such as diabetes. Epidemiological studies and figures have demonstrated the growing incidence of diabetes. Relevantly, the side effects of chemical drugs have led patients to use medicinal plants and traditional approaches despite advances in development of chemical drugs. The aim of this review article is to report the medicinal plants and their traditional uses to prevent and treat diabetes according to the findings of ethnobotanical studies conducted in different regions of Iran...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28937913/dietary-euphorbia-hirta-extract-improved-the-resistance-of-sharptooth-catfish-clarias-gariepinus-to-aeromonas-hydrophila
#6
Atefeh Sheikhlar, Goh Yong Meng, Razak Alimon, Nicholas Romano, Mahdi Ebrahimi
Aqueous and methanol extracts of lemon Citrus limon peel, Euphorbia hirta (aerial parts), and fenugreek Trigonella foenum-graecum seeds were tested for their in vitro antimicrobial activities against the bacterium Aeromonas hydrophila. A swab paper disk method showed that the methanol extract of E. hirta (EHE) had the largest inhibition zone and the lowest minimal inhibitory concentration compared to all other herbal extracts. Based on these results, EHE was included in the diets of Sharptooth Catfish Clarias gariepinus at 0 (control), 2, 5, or 7 g/kg of diet (experiment 1)...
December 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#7
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28898430/effect-of-drying-methods-on-the-structure-thermo-and-functional-properties-of-fenugreek-trigonella-foenuem-graecum-protein-isolate
#8
Samira Feyzi, Mehdi Varidi, Fatemeh Zare, Mohammad Javad Varidi
BACKGROUND: Different drying methods due to protein denaturation could alter proteins' functional properties, as well as structure. So, this study focused on the effect of different drying methods on amino acid content, thermo and functional properties, and protein structure of fenugreek protein isolate. RESULTS: Freeze and spray drying methods resulted in comparable protein solubility, dynamic surface and interfacial tensions, foaming and emulsifying properties except for emulsion stability...
September 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28894630/an-ethnobotanical-survey-of-galactogenic-plants-of-the-berhoum-district-m-sila-algeria
#9
Sarri Madani, Boudjelal Amel, Hendel Noui, Sarri Djamel, Hamdaoui Hadjer
BACKGROUND/AIM: This work aimed an ethnobatanical study on the galactogenic plants used in the Berhoum region (East of M'sila, Algeria) as a part of different studies on the medicinal plants related to M'sila region. METHODS: The fieldwork was undertaken as an ethnobotanical survey involving 76 informants (mean age: 50; 64% women, 36% men). Used the medicinal plants were identified, and the results were analyzed according to literature investigation dealing with ethnobotany...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28816550/a-review-on-biosynthesis-analytical-techniques-and-pharmacological-activities-of-trigonelline-as-a-plant-alkaloid
#10
Neda Mohamadi, Fariba Sharififar, Mostafa Pournamdari, Mehdi Ansari
Trigonelline (TRG) as a polar hydrophilic alkaloid is extracted from many plant species, for example, Trigonella foenum-graecum, Allium sepapea, Coffea sp, Pissum sativum, Glycine max, and Lycopersicon esculentum. Numerous biological activities have been reported for TRG such as protection of heart and liver and treatment of hyperglycemia, hypercholesterolemia, nervous and hormonal disorders, and cancers. Thus, the aim of this review is to summarize some information about TRG's biosynthesis pathway, pharmacological activity, pharmacokinetics, and analytical techniques to introduce TRG as an alternative choice to treat the various diseases...
August 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28729836/an-overview-of-herbal-products-and-secondary-metabolites-used-for-management-of-type-two-diabetes
#11
REVIEW
Ajda Ota, Nataša P Ulrih
Diabetes mellitus is a common effect of uncontrolled high blood sugar and it is associated with long-term damage, dysfunction, and failure of various organs. In the adult population, the global prevalence of diabetes has nearly doubled since 1980. Without effective prevention and management programs, the continuing significant rise in diabetes will have grave consequences on the health and lifespan of the world population, and also on the world economy. Supplements can be used to correct nutritional deficiencies or to maintain an adequate intake of certain nutrients...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28707431/efficacy-of-a-proprietary-trigonella-foenum-graecum-l-de-husked-seed-extract-in-reducing-menopausal-symptoms-in-otherwise-healthy-women-a-double-blind-randomized-placebo-controlled-study
#12
RANDOMIZED CONTROLLED TRIAL
E Steels, M L Steele, M Harold, S Coulson
Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed)...
September 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28694778/north-african-medicinal-plants-traditionally-used-in-cancer-therapy
#13
REVIEW
Jorge M Alves-Silva, Abderrahmane Romane, Thomas Efferth, Lígia Salgueiro
Background: Cancer is a major cause of mortality worldwide with increasing numbers by the years. In North Africa, the number of cancer patients is alarming. Also shocking is that a huge number of cancer patients only have access to traditional medicines due to several factors, e.g., economic difficulties. In fact, medicinal plants are widely used for the treatment of several pathologies, including cancer. Truthfully, herbalists and botanists in North African countries prescribe several plants for cancer treatment...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28679380/a-novel-botanical-formula-prevents-diabetes-by-improving-insulin-resistance
#14
Juntao Kan, Rodney A Velliquette, Kerry Grann, Charlie R Burns, Jeff Scholten, Feng Tian, Qi Zhang, Min Gui
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigonella foenum graecum) seed, mulberry (Morus alba L.) leaf and American ginseng (Panax quinquefolius) root can improve glycemia in various animal models and humans with impaired glucose metabolism and T2DM. The aim of this study was to design an optimized botanical formula containing these herbal extracts as a nutritional strategy for the prevention of insulin resistance and T2DM...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28663151/a-comparison-of-chemical-structural-and-functional-properties-of-fenugreek-trigonella-foenum-graecum-protein-isolates-produced-using-different-defatting-solvents
#15
Samira Feyzi, Mehdi Varidi, Fatemeh Zare, Mohammad Javad Varidi
This study showed defatting solvents including hexane, diethyl ether, chloroform, ethanol and acetone, due to their influence on protein denaturation and structure, have considerable effect on the amino acid composition, thermal characterizations, surface and functional properties of fenugreek protein isolate. FTIR analysis while confirmed the presence of secondary structures in all fenugreek protein isolates, showed differences in these structures. Hexane and diethyl ether resulted in comparable coagulated protein percentage, interfacial tension, emulsifying properties, surface hydrophobicity, Td and SDS-PAGE profile in fenugreek protein isolates...
December 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28625957/studies-on-antihyperlipidemic-and-endothelium-modulatory-activities-of-polyherbal-formulation-pol4-and-its-ingredients-in-high-fat-diet-fed-rats
#16
Abdul Malik, Malik Hassan Mehmood, Muhammad Shoaib Akhtar, Ghulam Haider, Anwarul Hassan Gilani
A compound herbal formulation (POL4) is used traditionally in interior parts (Distt. Badin) of Sindh, Pakistan, for the treatment of metabolic disorders like diabetes and hyperlipidemia. This study is aimed to determine the effectiveness of POL4 and its ingredients in hyperlipidemia and associated endothelial dysfunction and hypertension. POL4 is composed of equal proportion of Nigella sativa, Cichorium intybus, Trigonella foenum graecum and Gymnema sylvestre mixed in powdered form. Chronic (6 to 7 weeks) administration of POL4 and its ingredients mixed in diet caused a notable attenuation in total cholesterol, low density lipoprotein cholesterol, triglycerides, atherogenic index, C-reactive protein and glucose, while it has increased high density lipoprotein levels...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28618121/specificity-traits-consistent-with-legume-rhizobia-coevolution-displayed-by-ensifer-meliloti-rhizosphere-colonization
#17
María Eugenia Salas, Mauricio Javier Lozano, José Luis López, Walter Omar Draghi, Javier Serrania, Gonzalo Arturo Torres Tejerizo, Francisco Javier Albicoro, Juliet Fernanda Nilsson, Mariano Pistorio, María Florencia Del Papa, Gustavo Parisi, Anke Becker, Antonio Lagares
Rhizobia are α- and ß-proteobacteria that associate with legumes in symbiosis to fix atmospheric nitrogen. The chemical communication between roots and rhizobia begins in the rhizosphere. Using signature-tagged-Tn5 mutagenesis (STM) we performed a genome-wide screening for Ensifer meliloti genes that participate in colonizing the rhizospheres of alfalfa and other legumes. The analysis of ca. 6,000 mutants indicated that genes relevant for rhizosphere colonization account for nearly 2% of the rhizobial genome and that most (ca...
June 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28599386/amelioration-of-hyperglycemia-and-associated-metabolic-abnormalities-by-a-combination-of-fenugreek-trigonella-foenum-graecum-seeds-and-onion-allium-cepa-in-experimental-diabetes
#18
Seetur R Pradeep, Krishnapura Srinivasan
BACKGROUND: Fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) are independently known to have antidiabetic effects through different mechanisms. The beeneficial influence of a combination of dietary fenugreek seeds and onion on hyperglycemia and its associated metabolic abnormalities were evaluated in streptozotocin-induced diabetic rats. METHODS: Diabetes was experimentally induced with streptozotocin and diabetic rats were fed with 10% fenugreek or 3% onion or their combination for 6 weeks...
September 26, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28584446/antimicrobial-activity-of-various-ethanolic-plant-extracts-against-pathogenic-multi-drug-resistant-candida-spp
#19
Shaista Khan, Mohd Imran, Mohammed Imran, Nuzhat Pindari
A total of 50 Candida isolates were isolated and identified from clinical specimens and these were tested for resistance to various antifungal drugs. It was observed multi-drug resistance in all candida isolates by 84%, 62%, 60%, 76%, 46, 30%, and 22% against fluconazole, clotrimazole, Amphotericin B, itraconazole, ketoconazole, miconazole and nystatin tested respectively. The isolates, which were found to be resistant to antifungal drugs were selected and subjected to antifungal testing against six ethanolic plants, extract namely Azadiracta indica, Allium sativum, Cordia dichotoma Ocimum sanctum, Syzygium cumini and Trigonella foenum grecum...
2017: Bioinformation
https://www.readbyqxmd.com/read/28558255/anti-inflammatory-subfractions-separated-from-acidified-chloroform-fraction-of-fenugreek-seeds-trigonella-foenum-graecum-l
#20
Mostafa Pournamdari, Ali Mandegary, Fariba Sharififar, Ghazaleh Zarei, Rahele Zareshahi, Amir Asadi, Mohammad Mehdipour
Considering the side effects of current anti-inflammatory drugs, novel therapeutic agents are desired. We have succeeded in separating flavonoid-rich fractions with anti-inflammatory effect from fenugreek seeds (Trigonella foenum-graecum L.). In this work, we aimed to carry out further fractionation to find active anti-inflammatory subfractions. Trigonelline content of the plant was determined by spectrophotometric method. Fenugreek seeds were extracted consecutively with petroleum ether, acidified chloroform (ACC), alkaline chloroform (AKC), methanol, and water...
May 30, 2017: Journal of Dietary Supplements
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