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https://www.readbyqxmd.com/read/29783752/pro-apoptotic-and-anti-cancer-properties-of-diosgenin-a-comprehensive-and-critical-review
#1
REVIEW
Gautam Sethi, Muthu K Shanmugam, Sudha Warrier, Myriam Merarchi, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee
Novel and alternative options are being adopted to combat the initiation and progression of human cancers. One of the approaches is the use of molecules isolated from traditional medicinal herbs, edible dietary plants and seeds that play a pivotal role in the prevention/treatment of cancer, either alone or in combination with existing chemotherapeutic agents. Compounds that modulate these oncogenic processes are potential candidates for cancer therapy and may eventually make it to clinical applications. Diosgenin is a naturally occurring steroidal sapogenin and is one of the major bioactive compounds found in dietary fenugreek ( Trigonella foenum-graecum ) seeds...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29768242/antibacterial-anticancer-and-antioxidant-potential-of-silver-nanoparticles-engineered-using-trigonella-foenum-graecum-seed-extract
#2
Shivangi Goyal, Nidhi Gupta, Ajeet Kumar, Sreemoyee Chatterjee, Surendra Nimesh
In this study, the authors report a simple and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using Trigonella foenum-graecum (TFG) seed extract. They explored several parameters dictating the biosynthesis of TFG-AgNPs such as reaction time, temperature, concentration of AgNO3 , and TFG extract amount. Physicochemical characterisation of TFG-AgNPs was done on dynamic light scattering (DLS), field emission electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29749534/comparative-whole-genome-transcriptome-analysis-and-fenugreek-leaf-extract-modulation-on-cadmium%C3%A2-induced-toxicity-in-liver-cells
#3
Caroline Odewumi, Lekan M Latinwo, Roy Leonard Lyles, Veera L D Badisa, Cobb-Abdullah Ahkinyala, Marijo Kent-First
Cadmium (Cd), an economically valuable metal, is widely used in various industrial processes. Although it is of economic value, it is hazardous to human health. Cd accumulates in vital organs where it causes various diseases. Natural compounds with chelating or antioxidant properties have been tested to reduce the toxic effect of Cd. The anti‑oxidant, anti‑diabetic and hypocholesterolemic properties of fenugreek (Trigonella foenum-graecum) leaves make it a candidate for investigation as protective agent against Cd‑induced toxicity...
May 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29744355/herbal-medicine-for-oligomenorrhea-and-amenorrhea-a-systematic-review-of-ancient-and-conventional-medicine
#4
REVIEW
Arezoo Moini Jazani, Kobra Hamdi, Mojgan Tansaz, Hossein Nazemiyeh, Homayoun Sadeghi Bazargani, Seyed Mohammad Bagher Fazljou, Ramin Nasimi Doost Azgomi
Introduction: Menstrual bleeding cessation is one of the most frequent gynecologic disorders among women in reproductive age. The treatment is based on hormone therapy. Due to the increasing request for alternative medicine remedies in the field of women's diseases, in present study, it was tried to overview medicinal plants used to treat oligomenorrhea and amenorrhea according to the pharmaceutical textbooks of traditional Persian medicine (TPM) and review the evidence in the conventional medicine...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29743896/investigating-the-effectiveness-of-the-trigonella-foenum-graecum-l-fenugreek-seeds-in-mild-asthma-a-randomized-controlled-trial
#5
Majid Emtiazy, Laleh Oveidzadeh, Minoo Habibi, Leila Molaeipour, Daryush Talei, Zahra Jafari, Mahmoud Parvin, Mohammad Kamalinejad
Background: Asthma is one of the important chronic diseases. The asthma prevalence is increasing in last decades. Despite the presence of good controller drugs like corticosteroids, about 60% of asthmatic patients use alternative medicine. This study was done to determine the effectiveness of Tregonella foenum graceum (fenugreek) seeds in mild asthma. Methods: It is a double blind trial with placebo effect. One of the ancient prescriptions from Persian Medicine was selected...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29705508/biosynthesis-of-iron-nanoparticles-using-trigonella-foenum-graecum-seed-extract-for-photocatalytic-methyl-orange-dye-degradation-and-antibacterial-applications
#6
Ibrahim Ali Radini, Nazim Hasan, Maqsood Ahmad Malik, Zaheer Khan
Trigonella foenum-graecum is the source of various biological and chemical constituents with a wide area of applications, especially in the treatment/prevention of diabetes and other chronic diseases such as cancer. Multiple biological and organic moieties in the aqueous or the organic phase of Trigonella foenum-graecum carry soft reduction properties to reduce the metal cations to nanoparticles. In this investigation, the Trigonella foenum-graecum was found in the seed extract for the first time in an aqueous medium...
April 17, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29681009/effect-of-trigonella-foenum-graecum-linn-seeds-methanol-extract-on-learning-and-memory
#7
Tahira Assad, Rafeeq Alam Khan, Muhammad Ali Rajput
Prevention and delay in the onset of memory disorders will have a great impact on society by reducing the disease burden and finances. Drugs available for the treatment of learning and memory disorders are few. There is need to develop a better drug, several studies have shown the therapeutic effectiveness of herbal extracts for the learning and memory disorders because of their neuroprotective effects, hence herbs should be evaluated scientifically to form a basis for the future discovery of newer drugs. In this study, effect of Trigonella-foenum graecum L...
April 21, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29676912/bioactivity-guided-isolation-of-potential-antidiabetic-and-antihyperlipidemic-compounds-from-trigonella-stellata
#8
Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly
The in vitro antidiabetic and antihyperlipidemic activities of an alcoholic extract of Trigonella stellata were evaluated in terms of the activation of PPARα and PPARγ in human hepatoma (HepG2) cells. The extract was investigated phytochemically, aiming at the isolation of the most active compounds to be used as a platform for drug discovery. Three new isoflavans, (3 S,4 R)-4,2',4'-trihydroxy)-7-methoxyisoflavan (1), (3 R,4 S)-4,2',4'-trihydroxy-7-methoxy-4'- O-β-d-glucopyranosylisoflavan (2), and (2 S,3 R,4 R)-4,2',4'-trihydroxy-2,7-dimethoxyisoflavan (3), were isolated and characterized along with the five known compounds p-hydroxybenzoic acid (4), 7,4'-dihydroxyflavone (5), dihydromelilotoside (6), quercetin-3,7- O-α-l-dirhamnoside (7), and soyasaponin I (8)...
April 20, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#9
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29621421/role-of-bulk-and-nanosized-sio-2-to-overcome-salt-stress-during-fenugreek-germination-trigonella-foenum-graceum-l
#10
Reihane Ivani, Seyed Hossein Sanaei Nejad, Bijan Ghahraman, Ali Reza Astaraei, Hassan Feizi
The effects of bulk and Nanosized SiO2 on seed germination and seedling growth indices of fenugreek under salinity stress were studied in the College of Agriculture, Ferdowsi University of Mashhad, Iran, in 2013. The experimental treatments included four levels of salinity stress (0, 50, 100 and 150 mM), two concentrations of bulk (50 and 100 ppm), two concentrations of nanosized SiO2 (50 and 100 ppm), and control (without any SiO2 types). Seedling growth attributes significantly improved when bulk and nanosized SiO2 concentrations applied singly or with different levels of salt stress...
April 5, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29577753/purification-of-the-total-steroidal-saponins-from-fenugreek-seeds-trigonella-foenum-graecum-l-using-aqueous-two-phase-system-and-determination-of-diosgenin-content-using-micellar-electrokinetic-chromatography-method
#11
Na Wang, Famei He, Wenliang Li, Xu Fang, Hailing Li
The total steroidal saponins, particularly its major steroidal sapogenin (diosgenin), are the main active principles of fenugreek seed extract. In this study, an ethanol-salt aqueous two-phase system (ATPS) was explored for the purification of the total steroidal saponins, and the process conditions were optimized by response surface methodology (RSM). Under the optimized conditions, the RSM predicted recovery of the total steroidal saponins in the top phase of ATPS was 97.9%, which agreed with the average experimental recovery (98...
March 26, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29556428/improving-changes-in-physical-sensory-and-texture-properties-of-cake-supplemented-with-purified-amylase-from-fenugreek-trigonella-foenum-graecum-seeds
#12
Bassem Khemakhem, Slim Smaoui, Hanen El Abed, Imen Fendri, Hajer Hammami, Mohamed Ali Ayadi
Three different concentrations of a purified maltogenic amylase (FSA) from fenugreek ( Trigonella foenum graecum ) seeds were incorporated into the cake formulation. The addition of FSA at 0.003, 0.005 and 0.01 U/g of cake increased the loaf volume, the number of holes (gas cells), and water absorption. Textural study revealed an improvement of the cake quality, resulting in the decrease of hardness and the increase of cohesion. Environmental scanning electron microscopy was performed on different cakes to evaluate the influence of amylase activity on microstructure...
March 2018: 3 Biotech
https://www.readbyqxmd.com/read/29534453/fenugreek-trigonella-foenum-graecum-seed-flour-and-diosgenin-preserve-endothelium-dependent-arterial-relaxation-in-a-rat-model-of-early-stage-metabolic-syndrome
#13
Katalin Szabó, Rudolf Gesztelyi, Nóra Lampé, Rita Kiss, Judit Remenyik, Georgina Pesti-Asbóth, Dániel Priksz, Zoltán Szilvássy, Béla Juhász
Fenugreek is a common herb possessing several bioactive components including diosgenin. Here, dietary fenugreek seed flour and diosgenin were evaluated on a model of endothelium-dependent vasorelaxation by abdominal aortas isolated from rats receiving high-fat, high-sugar diet (HFHSD). 60 male Wistar rats were randomized into six groups: (i) negative control getting conventional rat feed regimen; (ii) positive control receiving HFHSD; (iii) a test group fed 2 g/kg bw/day fenugreek seed flour (containing 10 mg/kg bw/day diosgenin) + HFHSD; (iv) three test groups fed 1, 10 and 50 mg/kg bw/day diosgenin + HFHSD...
March 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29485633/effects-of-fermented-ginger-rhizome-zingiber-officinale-and-fenu-greek-trigonella-foenum-graceum-supplements-on-oxidative-stress-and-lipid-peroxidation-biomarkers-in-poloxamer-407-induced-hyperlipidemic-wistar-rats
#14
Y Tanko, A Kabiru, A Abdulrasak, K A Mohammed, A I Salisu, A Jimoh, N M Gidado, N M Sada
This research was aimed at investigating the Effects of Fermented Ginger Rhizome (Zingiber officinale) and Fenu Greek (Trigonella foenum-graceum) on Oxidative stress and Lipid Peroxidation Biomarkers in Poloxamer 407Induced-Hyperlipidemic Wistar Rats. Hyperlipidaemia was induced with poloxamer P407 (1.5 g/kg   b.w. i.p.) The Animals were grouped into six of five animals each group. Group 1 normal control, Group 2 served as the hyperlipidemic control, Group 3 administered 0.26 g/kg cholestyramine, Group 4 fed on Fenugreek 25% supplement...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29462748/dietary-administration-effects-of-fenugreek-seeds-on-skin-mucosal-antioxidant-and-immunity-status-of-gilthead-seabream-sparus-aurata-l
#15
F A Guardiola, A Bahi, A M Jiménez-Monreal, M Martínez-Tomé, M A Murcia, M A Esteban
Improving fish defense through the preventive administration of immunostimulants has an important role in controlling the outbreak of the disease in aquaculture. As a continuity of our previous studies, this paper describes the effects of dietary fenugreek (Trigonella foenum graecum) seeds on the skin mucosal antioxidant status and immune response of gilthead seabream (Sparus aurata L.). Fish were fed with four experimental diets: one a basal diet (control) and three diets with powdered fenugreek seeds incorporated in the fish feed at 1%, 5%, and 10%...
April 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#16
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29366863/green-synthesis-of-titanium-dioxide-tio-2-nanoparticles-by-trigonella-foenum-graecum-extract-and-its-antimicrobial-properties
#17
S Subhapriya, P Gomathipriya
In recent years, biosynthesis of nanoparticles has received considerable attention due to the growing need to develop clean and nontoxic chemicals, low-cost approaches, eco - friendly solvents and renewable materials. In the current study, the biosynthesis of TiO2 nanoparticles (TiO2 NPs) was attained by a chemical and biosynthesized method by using the aqueous leaf extract of Trigonella foenum-graecum (TF-TiO2 NP). TiO2 NPs were characterized by FTIR, UV, XRD, HR-TEM and HR-SEM methods. The X-ray diffraction displayed the existence of TF-TiO2 NPs which is confirmed by the incidence of peaks at 25...
March 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29366034/anti-diabetic-effect-of-trigonella-foenum-greacum-seed-acetone-fraction-in-a-type-2-diabetes-model-of-rats
#18
Nitin Kumar, R K Khanna
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29337247/effects-of-dietary-administration-of-fenugreek-seeds-on-metabolic-parameters-and-immune-status-of-gilthead-seabream-sparus-aurata-l
#19
F A Guardiola, A Bahi, M A Esteban
Medical plants could be used as a prophylactic method in aquaculture because they are considered safe and so very promising alternatives to the use of chemicals. The aim of the present work was to examine the effects of dietary fenugreek (Trigonella foenum graecum) seeds administered for 8 weeks on the metabolic and immune status of gilthead seabream (Sparus aurata L.). Four experimental groups were designated: one receiving a basal diet (control) and three fed powdered fenugreek seeds incorporated in the fish feed at 1%, 5% and 10%...
March 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29275179/haemato-protective-influence-of-dietary-fenugreek-trigonella-foenum-graecum-l-seeds-is-potentiated-by-onion-allium-cepa-l-in-streptozotocin-induced-diabetic-rats
#20
Seetur R Pradeep, Krishnapura Srinivasan
We have recently reported the beneficial modulation of metabolic abnormalities and oxidative stress in diabetic rats by dietary fenugreek seeds and onion. This investigation evaluated the protective influence of dietary fenugreek seeds (100 g kg-1 ) and onion (30 g kg-1 ) on erythrocytes of streptozotocin-induced diabetic rats, through modulation of reduced haematological indices and antisickling potency. This study also evaluated the altered erythrocyte membrane lipid profile and beneficial countering of increased lipid peroxidation, osmotic fragility, along with reduced membrane fluidity and deformability, nitric oxide production and echinocyte formation...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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