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https://www.readbyqxmd.com/read/28214690/safety-and-efficacy-of-a-polyherbal-formulation-for-the-management-of-dyslipidemia-and-hyperglycemia-in-patients-with-advanced-stage-of-type-2-diabetes
#1
Mahdi Zarvandi, Hassan Rakhshandeh, Mohammad Abazari, Reza Shafiee-Nick, Ahmad Ghorbani
The present clinical trial was designed to evaluate the safety and efficacy of a polyherbal formulation (PHF) consisted of Allium sativum, Aloe vera, Nigella sativa, Plantago psyllium, Silybum marianum and Trigonella foenum-graecum for controlling dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes. An open-label phase I trial was carried out on 30 patients who had hyperlipidemia and hyperglycemia before the beginning of the trial in spite of receiving statins and oral hypoglycemic drugs...
February 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28199188/trigonella-seed-extract-ameliorates-inflammation-via-regulation-of-the-inflammasome-adaptor-protein-asc
#2
Nidhi Sharma, Samyuktha Suresh, Ananya Debnath, Sushmita Jha
Trigonella foenum-graecum (fenugreek) is an important medicinal plant, well known for its anti-inflammatory properties. However, the underlying cellular and molecular mechanisms of its action remain largely unknown. The apoptosis associated speck like protein containing a caspase recruitment domain (CARD) (ASC) is central to inflammatory and cell death pathways in innate and adaptive immunity. Here, we show that fenugreek seed extract provides cytoprotection to bacterial lipopolysaccharide (LPS) inflammed and nanosilica-treated fibroblasts via a reactive oxygen species independent pathway...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28161815/next-generation-sequencing-of-representational-difference-analysis-products-for-identification-of-genes-involved-in-diosgenin-biosynthesis-in-fenugreek-trigonella-foenum-graecum
#3
Joanna Ciura, Magdalena Szeliga, Michalina Grzesik, Mirosław Tyrka
Representational difference analysis of cDNA was performed and differential products were sequenced and annotated. Candidate genes involved in biosynthesis of diosgenin in fenugreek were identified. Detailed mechanism of diosgenin synthesis was proposed. Fenugreek (Trigonella foenum-graecum L.) is a valuable medicinal and crop plant. It belongs to Fabaceae family and has a unique potential to synthesize valuable steroidal saponins, e.g., diosgenin. Elicitation (methyl jasmonate) and precursor feeding (cholesterol and squalene) were used to enhance the content of sterols and steroidal sapogenins in in vitro grown plants for representational difference analysis of cDNA (cDNA-RDA)...
February 4, 2017: Planta
https://www.readbyqxmd.com/read/28157172/extraction-of-fenugreek-trigonella-foenum-graceum-l-seed-oil-using-subcritical-butane-characterization-and-process-optimization
#4
Ling-Biao Gu, Xiao-Ning Liu, Hua-Min Liu, Hui-Li Pang, Guang-Yong Qin
In this study, the subcritical butane extraction process of fenugreek seed oil was optimized using response surface methodology with a Box-Behnken design. The optimum conditions for extracted oil from fenugreek seed was as follows: extraction temperature of 43.24 °C , extraction time of 32.80 min, and particle size of 0.26 mm. No significant differences were found between the experimental and predicted values. The physical and chemical properties of the oil showed that the oil could be used as edible oil. Fatty acid composition of oils obtained by subcritical butane under the optimum conditions and by accelerated solvent extraction showed negligible difference...
February 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28143746/structure-functional-and-antioxidant-properties-in-tunisian-beef-sausage-of-a-novel-polysaccharide-from-trigonella-foenum-graecum-seeds
#5
Naourez Ktari, Amal Feki, Imen Trabelsi, Mehdi Triki, Hana Maalej, Sirine Ben Slima, Moncef Nasri, Ibtissem Ben Amara, Riadh Ben Salah
A novel polysaccharide named Fenugreek Water-Soluble Polysaccharide (FWSP), consisting of a gluconic acid polymer, was isolated from fenugreek seeds. It was structurally characterized by Fourier transformed infrared (FT-IR), X-ray diffraction (XRD), High performance liquid chromatograpy (HPLC), and Nuclear magnetic resonance (NMR) spectroscopies. FT-IR and NMR spectra showed the characteristic bands of polysaccharides. According to XRD spectrum, FWSP is a semi-crystalline polymer. Functional properties of FWSP were investigated based on Water Holding Capacity (WHC), Oil Holding Capacity (OHC), emulsification activity, and foaming ability...
January 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28138310/efficacy-of-furosap-tm-a-novel-trigonella-foenum-graecum-seed-extract-in-enhancing-testosterone-level-and-improving-sperm-profile-in-male-volunteers
#6
Anuj Maheshwari, Narsingh Verma, Anand Swaroop, Manashi Bagchi, Harry G Preuss, Kiran Tiwari, Debasis Bagchi
Background: Dietary fiber rich fenugreek (Trigonella foenum-graecum) seeds have exhibited cardioprotective, hypolipidemic and other health benefits. Furosap (FS), an innovative, patented, 20% protodioscin-enriched extract was developed in our laboratory from fenugreek seeds. This study examined the free and total testosterone levels, sperm profile and morphology, sexual health, mood and mental alertness, and broad spectrum safety parameters of FS in 50 male volunteers following supplementation over a period of 12 weeks...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28126941/genome-sequence-of-the-symbiotic-type-strain-rhizobium-tibeticum-ccbau85039t
#7
Gonzalo Torres Tejerizo, Daniel Wibberg, Anika Winkler, Ernesto Ormeño-Orrillo, Esperanza Martínez-Romero, Karsten Niehaus, Alfred Pühler, Jörn Kalinowski, Antonio Lagares, Andreas Schlüter, Mariano Pistorio
Rhizobium tibeticum was originally isolated from root nodules of Trigonella archiducis-nicolai grown in Tibet, China. This species is also able to nodulate Medicago sativa and Phaseolus vulgaris The whole-genome sequence of the type strain, R. tibeticum CCBAU85039(T), is reported in this study.
January 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28107731/natural-amelioration-of-zinc-oxide-nanoparticle-toxicity-in-fenugreek%C3%A2-trigonella-foenum-gracum-by-arbuscular-mycorrhizal-glomus-intraradices-secretion-of-glomalin
#8
Narges Ghasemi Siani, Seyfollah Fallah, Lok Raj Pokhrel, Ali Rostamnejadi
Owing to rising production and use of engineered nanoparticles (ENPs) in the myriad of consumer applications, ENPs are being released into the environment where their potential fate and effects have remained unclear. With naturally occurring arbuscular mycorrhizal fungus (AMF; Glomus intraradices) in soils, their influence (positive or negative) on ENPs toxicity in plants is not well documented. Herein, we investigated potential influence of AMF on the growth and development in fenugreek (Trigonella foenum-graecum) under varied Zinc oxide nanoparticles (ZnONPs) treatments (0, 125, 250, 375 and 500 μg g(-1))...
January 3, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28092841/phytochemical-study-and-protective-effect-of-trigonella-foenum-graecum-fenugreek-seeds-against-carbon-tetrachloride-induced-toxicity-in-liver-and-kidney-of-male-rat
#9
Sakhria Mbarki, Hichem Alimi, Hafsia Bouzenna, Abdelfettah Elfeki, Najla Hfaiedh
Liver and kidney diseases are a global concern, therefore considerable efforts to obtain fine herbs useful as drugs from medicinal plants are currently in progress. The aim of this work was to study the antioxidant effects of previous supplementation with fenugreek seeds (FS) against carbon tetrachloride (CCl4) toxicity in the liver and kidney. CCl4 toxicity was induced by one dose (i.g. 5ml CCl4/kg of body weight, 50% CCl4 in olive oil) after 7 weeks of normal diet or diet rich in 10% of grinded fenugreek seeds (20g of pellet rat food/rat/day)...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28088256/ethnobotanics-used-in-folk-medicine-of-tamil-culture-in-sri-lanka-a-scientific-review
#10
REVIEW
Anternite Shanthi Jesuthasan, Deepthi Inoka Uluwaduge
Tamil culture has recognized the potential use of plant herbs for prevention and treatment of different diseases. These folk remedies have been practiced by Sri Lankan Tamils even after modernization. This review focuses on frequently used medicinal plants among Sri Lankan Tamil communities, such as Cuminum cyminum, Azadirechta indica, Coriandrum sativum, Sesamum indicum, Zingiber officinale, Trigonella foenum-graecum, Moringa oleifera, Plectranthus amboinicus, Allium sativum and Curcuma longa, for their documented medicinal properties, which include antimicrobial, antioxidant, antitumor, anti-inflammatory, antihypertensive, hypocholesterolemic, antidiabetic and diuretic effects...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28049474/ethnopharmacological-survey-of-medicinal-plants-used-by-patients-with-psoriasis-in-the-west-bank-of-palestine
#11
Ramzi Shawahna, Nidal Amin Jaradat
BACKGROUND: Psoriasis is a frequent skin inflammatory disorder that inflicts millions of patients around the globe. To meet their healthcare needs, patients with psoriasis often seek treatment outside the allopathic paradigm. Use of medicinal plants has emerged as one of the most common and preferred modalities of complementary and alternative medicine (CAM). The aim of this study was to investigate the use of medicinal plants by patients with psoriasis in the West Bank of Palestine. METHODS: The current study was a questionnaire based cross-sectional descriptive study on the use of medicinal plants by psoriasis patients in the West Bank of Palestine...
January 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27975996/enhancement-of-diosgenin-extraction-from-fenugreek-trigonella-foenum-graecum-with-a-new-ionic-liquid-based-assisted-method
#12
S Aminkar, A Shojaeiyan, M Ayyari
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27939889/trigonella-foenum-graecum-alleviates-airway-inflammation-of-allergic-asthma-in-ovalbumin-induced-mouse-model
#13
Chun Hua Piao, Thi Tho Bui, Chang Ho Song, Hee Soon Shin, Dong-Hwa Shon, Ok Hee Chai
Trigonella foenum-graecum, a member oldest medicinal plant in the fabaceae (legumes) family, is used as a herb, spice, and vegetable, and known for its olfactory, laxative, and galactogogue effects. However, the inhibitory effect of Trigonella foenum-graecum on allergic inflammatory response remains unclear, therefore, we investigated the precise role of Trigonella foenum-graecum in the allergic asthma and revealed the effects of Trigonella foenum-graecum in regulating airway inflammation and its possible mechanism...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27914964/antioxidant-and-hemolytic-activities-and-effects-in-rat-cutaneous-wound-healing-of-a-novel-polysaccharide-from-fenugreek-trigonella-foenum-graecum-seeds
#14
Naourez Ktari, Imen Trabelsi, Sana Bardaa, Mehdi Triki, Intidhar Bkhairia, Rabab Ben Slama-Ben Salem, Moncef Nasri, Riadh Ben Salah
The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenum-graecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes. The application of FWEP hydrogel on the wound site in a rat model enhanced significantly wound healing activity and accelerated the wound closure after 14days of wound induction...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27893738/fenugreek-seed-powder-nullified-aluminium-chloride-induced-memory-loss-biochemical-changes-a%C3%AE-burden-and-apoptosis-via-regulating-akt-gsk3%C3%AE-signaling-pathway
#15
Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Mohammed D Akbar, Mohammed Akbar
Alzheimer's disease (AD) is the most common form of dementia that mainly affects the cognitive functions of the aged populations. Trigonella foenum-graecum (L.) (fenugreek), a traditionally well utilized medicinal plant ubiquitously used as one of the main food additive worldwide, is known to have numerous beneficial health effects. Fenugreek seed extract could be able to inhibit the activity of acetylcholinesterase (AChE), a key enzyme involved in the pathogenesis of AD, and further shown to have anti-parkinsonic effect...
2016: PloS One
https://www.readbyqxmd.com/read/27879673/4-hydroxyisoleucine-from-fenugreek-trigonella-foenum-graecum-effects-on-insulin-resistance-associated-with-obesity
#16
REVIEW
Anaguiven Avalos-Soriano, Ricardo De la Cruz-Cordero, Jorge L Rosado, Teresa Garcia-Gasca
Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effects on nonadipose tissues. 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27856325/effects-of-dietary-administration-of-fenugreek-seeds-alone-or-in-combination-with-probiotics-on-growth-performance-parameters-humoral-immune-response-and-gene-expression-of-gilthead-seabream-sparus-aurata-l
#17
A Bahi, F A Guardiola, C Messina, A Mahdhi, R Cerezuela, A Santulli, A Bakhrouf, M A Esteban
The use of immunostimulants is considered a promising preventive practice that may help to maintain animal welfare and a healthy environment, while increasing production and providing higher profits. The purpose of this study was to evaluate the effects on gilthead seabream (Sparus aurata L.) of the dietary administration of fenugreek (Trigonella foenum graecum) seeds, alone or combined with one of the following probiotic strains: Bacillus licheniformis (TSB27), Lactobacillus plantarum or Bacillus subtilis (B46)...
November 14, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27757260/medicinal-plants-used-by-traditional-healers-from-south-west-algeria-an-ethnobotanical-study
#18
Bachir Benarba
BACKGROUND/AIM: This study aimed to document and analyzes the local knowledge of medicinal plants' use by traditional healers in South-west Algeria. METHODS: The ethnobotanical survey was conducted in two Saharian regions of South-west of Algeria: Adrar and Bechar. In total, 22 local traditional healers were interviewed using semi-structured questionnaire and open questions. Use value (UV), fidelity level (FL), and informant consensus factor (FIC) were used to analyze the obtained data...
September 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27756958/anti-inflammatory-activity-of-fenugreek-trigonella-foenum-graecum-linn-seed-petroleum-ether-extract
#19
Kilambi Pundarikakshudu, Deepak H Shah, Aashish H Panchal, Gordhanbhai C Bhavsar
OBJECTIVES: The aim of the present work was to study the anti-inflammatory and anti-arthritic activities of petroleum ether extract of fenugreek seeds. MATERIALS AND METHODS: Fenugreek seed powder was extracted in petroleum ether by cold maceration. This fenugreek seed petroleum ether extract (FSPEE) was analyzed by gas-liquid chromatography (GLC) and tested on rats against carrageenan and formaldehyde-induced paw edema, complete Freund's adjuvant (CFA)-induced arthritis and cotton pellet-induced granuloma...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27733237/a-multicenter-clinical-study-to-determine-the-efficacy-of-a-novel-fenugreek-seed-trigonella-foenum-graecum-extract-fenfuro%C3%A2-in-patients-with-type-2-diabetes
#20
Narsingh Verma, Kauser Usman, Naresh Patel, Arvind Jain, Sudhir Dhakre, Anand Swaroop, Manashi Bagchi, Pawan Kumar, Harry G Preuss, Debasis Bagchi
BACKGROUND: Trigonella foenum-graecum (fenugreek) seeds are known to exhibit potent antioxidant, hypoglycemic, and nephroprotective activities, as well as serve as excellent membrane stabilizers especially because of their content of novel furostanolic saponins. Our previous studies exhibited the broad spectrum safety and efficacy of Fenfuro, a novel T. foenum-graecum seed extract enriched in furostanolic saponins, in type 2 diabetes (T2D) in rats. DESIGN: This multicenter, randomized, placebo-controlled, double-blind, add-on clinical study evaluated over a period of 90 consecutive days the efficacy of Fenfuro (daily dosage: 500 mg bid) in 154 subjects (male: 108; female: 46; age: 25-60 years) with T2D...
2016: Food & Nutrition Research
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