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Dexamethasone. Spinal Anaesthesia

Ahmed M Maged, Wesam Sayed Deeb, Sahar Elbaradie, Ahmed R Elzayat, Ahmed A Metwally, Mohamed Hamed, Ahmed Shaker
OBJECTIVE: To compare the effect of local infiltration and intravenous dexamethasone on postoperative pain and recovery after Cesarean Section (CS). MATERIAL AND METHODS: A Prospective, randomized study conducted on 120 pregnant women attending the labor wards. All participants were scheduled for elective CS under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1 received 16 mg Dexamethasone IV drip. Group II received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo (500 cc saline infusion)...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
M M Haque, M A Aleem, F H Haque, A B Siddique, R Afrose
Spinal anaesthesia with local anaesthetics has limited duration. Different additives have been used to prolong spinal anaesthesia. The aim of this study was to determine the efficacy of adding dexamethasone to bupivacaine in spinal anaesthesia specially whether it would prolong the duration of sensory block/ surgical analgesia and post-operative analgesia/pain free period or not. This randomized, prospective, double-blind, clinical study was conducted in the Department of Anaesthesia, Analgesia and Critical Care of Combined Military Hospital, Chittagong from October 2016 to August 2017...
April 2018: Mymensingh Medical Journal: MMJ
N P Edomwonyi, M O Osazuwa, O I Iribhogbe, S E Esangbedo
CONTEXT: Effective management of postcesarean section (CS) pain is important for the well-being of mother and child; even in limited-resource areas, there are drug options which can be explored to achieve this. AIM: This study aimed to compare the analgesic effects of a combination of bupivacaine wound infiltration with either intravenous (IV) dexamethasone or tramadol after CS. SETTING AND DESIGN: This study was a randomized, double-blind, comparative study in a tertiary hospital...
December 2017: Nigerian Journal of Clinical Practice
Archana B Narayanappa, Shivakumar Gurulingaswamy, Umesh N Prabhakaraiah, Somsundar R Gurushanth, Vinay Sapare, Nagaraj Goud
BACKGROUND AND AIMS: Post-operative nausea and vomiting (PONV) is one of the most common complications in patients undergoing gynaecological surgeries under spinal anaesthesia (SA). Palonosetron has the unique property of controlling 'delayed chemotherapy-induced nausea and vomiting' when compared to older serotonin antagonists. This study compared the effectiveness of palonosetron with a combination of ramosetron and dexamethasone in preventing PONV. METHODS: Sixty patients undergoing gynaecological surgeries under SA were randomly allocated into two groups of thirty each, to receive either a combination of 0...
February 2017: Indian Journal of Anaesthesia
R Vlok, T M Melhuish, C Chong, T Ryan, Leigh D White
The infiltration of local anaesthetic agents has been shown to reduce post-tonsillectomy pain. A number of recent studies have shown that the addition of agents such as clonidine and dexamethasone improve the efficacy of nerve blocks and spinal anaesthesia. The aim of this review was to determine whether additives to local anaesthetic agents improve post-tonsillectomy outcomes. Four major databases were systematically searched for all relevant studies published up to August 2016. All study designs with a control group receiving local anaesthetic infiltration and an intervention receiving the same infiltration with an added agent were included in this review...
August 2017: Journal of Anesthesia
Szilard Szucs, David Jessop, Gabriella Iohom, George D Shorten
BACKGROUND: Fractured neck of femur is a common cause of hospital admission in the elderly and usually requires operative fixation. In a variety of clinical settings, preoperative glucocorticoid administration has improved analgesia and decreased opioid consumption. Our objective was to define the postoperative analgesic efficacy of single dose of dexamethasone administered preoperatively in patients undergoing operative fixation of fractured neck of femur. METHODS: Institutional ethical approval was granted and written informed consent was obtained from each patient...
September 22, 2016: BMC Anesthesiology
Suresh Kumar N, Kiran N, Ravi M, Don Sebastian, Punith Gowda Rm
BACKGROUND: Patients with fracture femur experience severe pain on movement during positioning for spinal anaesthesia. Fascia Iliaca Compartment Block (FICB) has been used effectively for providing analgesia during positioning of the patient for spinal anaesthesia. AIM: To test the hypothesis that, adding dexamethasone would significantly prolong the duration of Bupivacaine in FICB. MATERIALS AND METHODS: Sixty patients aged 18 to 80 years posted for ORIF (Open Reduction and Internal Fixation) of fracture femur were included to receive FICB...
August 2014: Journal of Clinical and Diagnostic Research: JCDR
K U Tobi, C O Imarengiaye, F E Amadasun
BACKGROUND: Post-operative nausea and vomiting (PONV); early or late, has detrimental effects on surgical patients such as surgical wound disruption, esophageal tear and delayed discharge from the post anesthetic care unit. This study evaluated the effects of dexamethasone-metoclopramide (DM) in the prevention of early and late PONV in women undergoing myomectomy under subarachnoid block. MATERIALS AND METHODS: Following approval from the Research and Ethics Committee of the Hospital, informed consent was obtained from each prospective patient...
July 2014: Nigerian Journal of Clinical Practice
R G Bagomedov, V D Slepushkin, Kh M Omarova
The article deals with data of comparison of different antiemetic drugs used for prophylactics of intraoperative nausea and vomiting (IONV) during caesarian operation. 150 women included in the study were divided into three groups. Patients of the group-1 (80 women) received dproperidol 0.08-0.12 mg kg(-1) intravenously and atropine 0.006-0.009 mg kg(-1). Patients of the group-2 (50 women) received dexamethasone 0.04-0.1 mg kg(-1) intravenously. In the group-3 (20 women) patients received methoklopramide 0...
January 2014: Anesteziologiia i Reanimatologiia
A Akkaya, I Yildiz, U Y Tekelioglu, A Demirhan, H Bayir, T Ozlu, M Bilgi, H Kocoglu
OBJECTIVES: When added to local anaesthetics, dexamethasone can prolong the duration of peripheral blocks. Dexamethasone has a long and efficient glucocorticoid structure and presents anti-inflammatory properties. The aim of this study was to determine the effect of dexamethasone on the block duration added to levobupivacaine used for transversus abdominis block (TAP) applied to patients who underwent caesarean section. PATIENTS AND METHODS: Forty-two patients with spinal anaesthesia in an American Society of Anesthesiologists (ASA) I-II risk group were included in the study and divided into two groups...
2014: European Review for Medical and Pharmacological Sciences
A Demirhan, Y U Tekelioglu, A Akkaya, T Ozlu, I Yildiz, H Bayir, H Kocoglu, B Duran
BACKGROUND: Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of post-delivery intraoperative nausea and vomiting (IONV) during CS under spinal anesthesia. OBJECTIVE: To compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the single use of each agent to decrease the incidence of postdelivery IONV during CS under spinal anesthesia...
June 2013: African Health Sciences
Matthias Voigt, Christian W Fröhlich, Christiane Hüttel, Peter Kranke, Jan Mennen, Oliver Boessneck, Christian Lenz, Thalia Erbes, Jürgen Ernst, Heinz Kerger
BACKGROUND: This paper describes a randomized prospective study conducted in 308 patients undergoing caesarean section in spinal anaesthesia at a single hospital between 2010 and 2012 to find a suitable anti-emetic strategy for these patients. MATERIAL AND METHODS: Spinal anesthesia was performed in left prone position, at L3/L4 with hyperbaric 0.5% Bupivacaine according to a cc/cm body height ratio. There were no opioids given peri-operatively. The patients received either no prophylaxis (Group I) or tropisetron and metoclopramide (Group II) or dimenhydrinate and dexamethasone (Group III), or tropisetron as a single medication (Group IV)...
2013: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Xavier Basurto Ona, Sonia Maria Uriona Tuma, Laura Martínez García, Ivan Solà, Xavier Bonfill Cosp
BACKGROUND: Post-dural (post-lumbar or post-spinal) puncture headache (PDPH) is one of the most common complications of diagnostic, therapeutic or inadvertent lumbar punctures. Many drug options have been used to prevent headache in clinical practice and have also been tested in some clinical studies, but there are still some uncertainties about their clinical effectiveness. OBJECTIVES: To assess the effectiveness and safety of drugs for preventing PDPH in adults and children...
February 28, 2013: Cochrane Database of Systematic Reviews
Monica M S Cardoso, Alexandre O Leite, Elisa A Santos, Judymara L Gozzani, Lígia A S T Mathias
CONTEXT: Spinal morphine is a common form of postoperative analgesia after caesarean section, but it is associated with postoperative nausea and vomiting. OBJECTIVE: To evaluate the hypothesis that dexamethasone reduces nausea and vomiting in patients undergoing caesarean section under spinal anaesthesia with morphine. DESIGN: Interventional, randomised, double-blinded, placebo-controlled study to evaluate a preoperative single dose of dexamethasone...
March 2013: European Journal of Anaesthesiology
Pik Yan Chan, Monica Pik Lin Lee, Hester Yui Shan Cheung, Chi Chui Chung, Michael Ka Wah Li
OBJECTIVE: To identify the risk factors associated with unplanned admission after day-case haemorrhoidectomy. METHODS: This was a retrospective review of the outcomes of patients who underwent elective, intended day-case haemorrhoidectomy in a surgical institution between January 2005 and December 2009. Data were generated from a computerized database. Information on patient demographics, type of surgery, mode of anaesthesia, operative time, operation end time, and perioperative drugs were collected and analysed...
October 2010: Asian Journal of Surgery
A Tshibangu-N, F Motte-Neuville, E Gepts, A Bailly, T Nguyen, L Hirsoux
INTRODUCTION: Early feeding is well tolerated in patients undergoing caesarean section under general or regional anaesthesia. Intrathecal morphine is effective for postoperative analgesia but can induce nausea and vomiting which may hamper feeding. This study assessed prospectively the effects of intrathecal morphine on early feeding in patients undergoing caesarean section. METHODOLOGY: After ethical committee approval, 66 consenting women scheduled for caesarean section were randomized to receive intrathecal morphine 0...
February 2010: Annales Françaises D'anesthèsie et de Rèanimation
O Mathiesen, L S Jacobsen, H E Holm, S Randall, L Adamiec-Malmstroem, B K Graungaard, P E Holst, K L Hilsted, J B Dahl
BACKGROUND: Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure. METHODS: One hundred and twenty patients were randomly allocated to either Group A (placebo), Group B (pregabalin 300 mg), or Group C (pregabalin 300 mg+dexamethasone 8 mg). The medication and acetaminophen 1 g were given before operation...
October 2008: British Journal of Anaesthesia
A G Besocke, R Santamarina, L Martín Romano, R Alfredo Femminini
INTRODUCTION: Drug-induced aseptic meningitis (DIAM) is an uncommon adverse reaction secondary to the administration of numerous agents. It is diagnosed by exclusion, and its outcome is generally excellent with complete long term recovery. There are few reports of DIAM associated to intrathecal administration of bupivacaine in the literature. CASE REPORT: We present a 16 year-old male patient who received spinal anaesthesia with 10 mg of bupivacaine prior to orthopedic surgery...
October 2007: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Johannes G Förster, Per H Rosenberg
PURPOSE OF REVIEW: In this review, emphasis is placed on adjuvant drugs that are already in clinical use. The list of adjuvants studied during the review period includes adrenaline, clonidine, ketamine, neostigmine, nondepolarizing muscle relaxants, and nonsteroidal antiinflammatory drugs. Some future aspects are considered in a couple of experimental studies on slow-release local anaesthetic formulations. RECENT FINDINGS: Adrenaline not only acts as a vasoconstrictor, it may also produce analgesia through an alpha2-adrenergic mechanism...
October 2003: Current Opinion in Anaesthesiology
S-A Nortcliffe, J Shah, D J Buggy
BACKGROUND: Low-dose intrathecal (spinal) morphine (0.1-0.2 mg) for Caesarean section delivers excellent postoperative analgesia but is associated with significant nausea and vomiting. We compared the antiemetic efficacy of cyclizine, dexamethasone, and placebo in this clinical setting. METHODS: Ninety-nine women undergoing elective Caesarean section under spinal anaesthesia were allocated randomly, in a double-blind study design, to receive either cyclizine 50 mg, dexamethasone 8 mg, or placebo as a single-dose infusion in saline 0...
May 2003: British Journal of Anaesthesia
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