keyword
https://read.qxmd.com/read/38474257/extracorporeal-photopheresis-in-dermatological-diseases
#21
REVIEW
Hanna Terhaar, Mohammad Saleem, Nabiha Yusuf
Extracorporeal photopheresis (ECP) is an apheresis procedure that is conventionally used as a first-line treatment for cutaneous and leukemic subtypes of T-cell lymphoma, such as Sezary's syndrome and mycosis fungoides. Over the past three decades, its immunotherapeutic properties have been tested on a variety of autoimmune conditions, including many dermatologic diseases. There is ample evidence of ECP's ability to modify leukocytes and alter cytokine production for certain dermatologic diseases that have been refractory to first-line treatments, such as atopic dermatitis...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473401/the-neutrophil-to-lymphocyte-ratio-as-a-biomarker-in-cutaneous-oncology-a-systematic-review-of-evidence-beyond-malignant-melanoma
#22
REVIEW
Konstantinos Seretis, Konstantinos Sfaelos, Elena Boptsi, Georgios Gaitanis, Ioannis D Bassukas
With the ongoing progress of basic research along with the introduction of new pharmaceutical options spanning almost all therapeutic areas, the need for biomarkers that will be implemented into the personalized medical approach is higher than ever. Their use can be incorporated into clinical practice and can be applied to the classification of disorders and the evaluation of disease severity but also to the monitoring of the progress of therapeutic/pharmaceutical interventions. This systematic review collects the findings of hematologic biomarkers in various cutaneous malignancies, excluding malignant melanoma, to support their potential use in the prognosis but also in the assessment of therapeutic strategies for the specific category of skin disorders...
March 4, 2024: Cancers
https://read.qxmd.com/read/38473391/a-descriptive-study-of-103-primary-cutaneous-b-cell-lymphomas-clinical-and-pathological-characteristics-and-treatment-from-the-spanish-lymphoma-oncology-group-gotel
#23
JOURNAL ARTICLE
Natividad Martínez-Banaclocha, Francisca Martínez-Madueño, Berta Caballé, Joan Badia, Mar Blanes, David Aguiar Bujanda, Virginia Calvo, Jose Gómez Codina, Cristina Quero Blanco, Pablo Espinosa, Javier Lavernia, Francisco Ramón García Arroyo, María Guirado Risueño, Cristina Llorca, Raquel Cumeras, Mariano Provencio Pulla, Josep Gumà
Primary cutaneous B-cell lymphomas (PCBCLs) are B-cell lymphomas that can occur in the skin without evidence of extracutaneous involvement. The 2005 WHO/EORTC classification of cutaneous lymphomas and its 2018 update have distinguished three main categories based on clinicopathological, immunohistochemical, and genetic characteristics: primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle centre lymphoma (PCFCL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT)...
March 3, 2024: Cancers
https://read.qxmd.com/read/38473329/anti-pd-1-therapy-in-advanced-pediatric-malignancies-in-nationwide-study-good-outcome-in-skin-melanoma-and-hodgkin-lymphoma
#24
JOURNAL ARTICLE
Agata Marjańska, Katarzyna Pawińska-Wąsikowska, Aleksandra Wieczorek, Monika Drogosiewicz, Bożenna Dembowska-Bagińska, Katarzyna Bobeff, Wojciech Młynarski, Katarzyna Adamczewska-Wawrzynowicz, Jacek Wachowiak, Małgorzata A Krawczyk, Ninela Irga-Jaworska, Jadwiga Węcławek-Tompol, Krzysztof Kałwak, Małgorzata Sawicka-Żukowska, Maryna Krawczuk-Rybak, Anna Raciborska, Agnieszka Mizia-Malarz, Agata Sobocińska-Mirska, Paweł Łaguna, Walentyna Balwierz, Jan Styczyński
BACKGROUND/AIM: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment of childhood cancers is still evolving. The aim of this nationwide retrospective study was to assess the safety and effectiveness of ICIs used in a group of 42 patients, with a median age of 13.6 years, with various types of advanced malignancies treated in pediatric oncology centers in Poland between 2015 and 2023. RESULTS: The indications for treatment with anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); and other malignancies (14)...
February 28, 2024: Cancers
https://read.qxmd.com/read/38469302/editorial-the-underlying-pathophysiology-and-therapeutic-approaches-for-cutaneous-t-cell-lymphoma
#25
EDITORIAL
Patrizia Fuschiotti
No abstract text is available yet for this article.
2024: Frontiers in Immunology
https://read.qxmd.com/read/38468637/incidence-of-de-novo-post-transplant-malignancies-in-thai-adult-kidney-transplant-recipients-a-single-center-population-controlled-retrospective-cohort-study-at-the-highest-volume-kidney-transplant-center-in-thailand
#26
JOURNAL ARTICLE
Praopilad Srisuwarn, Napun Sutharattanapong, Sinee Disthabanchong, Surasak Kantachuvesiri, Chagriya Kitiyakara, Bunyong Phakdeekitcharoen, Atiporn Ingsathit, Vasant Sumethkul
Kidney transplant recipients (KTRs) are at increased risk of developing de novo post-transplant malignancies (PTMs), with regional differences in types with excess risk compared to the general population. A single-center, population-controlled, retrospective cohort study was conducted at a tertiary care center in Thailand among all adults who underwent their first kidney transplant from 1986 to 2018. Standardized incidence ratios (SIRs) of malignancy by age, sex, and place of residence were obtained using data from the National Cancer Registry of Thailand as population control...
2024: Transplant International
https://read.qxmd.com/read/38465934/additional-findings-of-18f-aif-fapi-42-pet-ct-in-a-patient-with-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-comparisons-with-18f-fdg-pet-ct
#27
JOURNAL ARTICLE
Guanghui Liu, Yaming Li, Bulin Du, Yan Cui, Xuena Li
A 44-year-old woman presented with extensive skin patches and pruritus persisting for 3 years. Histopathological examination of the skin from the right abdomen confirmed mycosis fungoides-type cutaneous T-cell lymphoma. Staging PET with 18F-FDG PET/CT) showed increased uptake in the skin on the right abdomen and left hip. Subsequently 18F-FAPI-42 PET/CT revealed additional foci of abnormal uptake on the skin of the chest and back.
February 29, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38465570/subcutaneous-panniculitis-like-t-cell-lymphoma-a-case-report
#28
JOURNAL ARTICLE
Ana Maria Lé, Rita Peixeiro, André Coelho, Renata Cabral, Iolanda Fernandes
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38465562/primary-cutaneous-extranodal-natural-killer-t-cell-lymphoma-with-delayed-expression-of-cd56
#29
JOURNAL ARTICLE
Aiko Kobayashi, Hiroyuki Goto, Airi Negishi-Asano, Junko Sowa-Osako, Sayaka Tanaka, Chisato Ohe, Kenichi Kohashi, Daisuke Tsuruta, Chiharu Tateishi
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38465552/linear-iga-bullous-dermatosis-in-association-with-nodal-peripheral-t-cell-lymphoma-with-a-t-follicular-helper-phenotype-and-multiple-myeloma-a-case-report-and-literature-review
#30
JOURNAL ARTICLE
Momone Masuda, Yukiko Kiniwa, Asuka Mikoshiba, Mariko Kasuga, Sayaka Nishina, Misae Oguchi, Norito Ishii, Ryuhei Okuyama
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38465551/acceleration-of-cutaneous-t-cell-lymphoma-mistaken-for-atopic-dermatitis-following-jak-inhibitor-use
#31
JOURNAL ARTICLE
Manon Lamolet, Cindy Barbarin, Olivier Renaud, Yusuf Sahin, Ewa Wierzbicka-Hainaut, Marie Masson Regnault
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38465548/epidemiological-trends-in-cutaneous-lymphomas-in-greece
#32
JOURNAL ARTICLE
Stella Kaliampou, Vasiliki Nikolaou, Aikaterini Niforou, Ioanna Kotsiopoulou, Maria Gerochristou, Asimina Papanikolaou, Georgios Kanellis, Evangelia Papadavid, Antonios Tsimpidakis, Evdoxia Pouliou, Elisavet Economaki, Evdoxia Panou, Christos Nikolaou, Alexander J Stratigos, Androniki Naska, Leonidas Marinos
Primary cutaneous lymphomas (PCLs) are a heterogenous group of non-Hodgkin lymphomas arising in the skin from T- or B-lymphocytes, for which there is limited epidemiological data available. To describe the disease characteristics and estimate annual incidence rates (IRs) and temporal trends of PCLs and their subtypes in Attica, Greece. A retrospective analysis of all PCL patients, diagnosed in Attica's main haemopathology referral centre from 2009 to 2021, was conducted. In total, 1,189 patients were included; 725 males and 464 females (males__females=1...
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38465544/pigmented-purpura-dermatosis-like-mycosis-fungoides-four-case-reports-and-a-review-of-published-cases
#33
REVIEW
Jingru Sun, Kecen Liu, Jingyang Dang, Shan Xiong, Haihao Pan, Yang Wang
Mycosis fungoides (MF) is the most prevalent type of cutaneous T-cell lymphoma and is generally characterized by multiple patches or plaques with fine scales. One of its variants manifests with multiple purpuric eruptions, mimicking benign pigmented purpuric dermatosis (PPD). To investigate clinicopathological features of PPD-like MF patients. We report four PPD-like MF cases and summarize the clinicopathological features described in reports of nine PPD-like MF cases published in the past 20 years. Compared with benign PPD, petechial lesions in PPD-like MF are more generalized, persistent, and resistant to conventional steroid treatment...
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38464827/rosmarinic-acid-protects-skin-keratinocytes-from-particulate-matter-2-5-induced-apoptosis
#34
JOURNAL ARTICLE
Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Jin Won Hyun
Background: The exposure of the human skin to particulate matter 2.5 (PM2.5 ) results in adverse health outcomes, such as skin aging, wrinkle formation, pigment spots, and atopic dermatitis. It has previously been shown that rosmarinic acid (RA) can protect keratinocytes from ultraviolet B radiation by enhancing cellular antioxidant systems and reducing oxidative damage; however, its protective action against the adverse effects of PM2.5 on skin cells remains unclear. Therefore, in this study, we explored the mechanism underlying the protective effects of RA against PM2...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38457671/febrile-ulceronecrotic-mucha-habermann-disease-associated-with-hemophagocytic-lymphohistiocytosis-a-case-report-and-review-of-the-literature
#35
JOURNAL ARTICLE
Caroline Chen, Lauren M Fahmy, Celine M Schreidah, Cynthia M Magro, Larisa J Geskin
Mucha-Habermann disease (MHD) is an inflammatory skin disease characterized by polymorphous eruptions of erythematous, necrotic macules that have been reported for similarities to cutaneous T-cell lymphoma. Febrile ulceronecrotic MHD (FUMHD) represents a severe variant of MHD, marked by ulcers, hemorrhagic bullae, and systemic symptoms. Herein, we report a case of a severely atypical lymphomatoid expression of FUMHD associated with hemophagocytic lymphohistiocytosis (HLH). A previously healthy 21-year-old woman was admitted to the hospital with a rapidly progressive necrotic papular rash...
April 1, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38454766/a-case-of-nasal-extranodal-nk-t-cell-lymphoma-of-lower-limb-muscle-revealed-by-18f-fdg-pet-ct
#36
Xianwen Hu, Wenxin Li, Dandan Li, Pan Wang, Jiong Cai
BACKGROUND: Extranodal NK/T-cell lymphoma (ENKTCL) is a type of malignant non-Hodgkin's lymphoma originating from mature T cells and NK cells, mainly involving the upper aerodigestive tract, including the nasal cavity, nasopharynx, oropharynx, oral cavity, hypopharynx, larynx, and occasionally the skin, salivary glands, testes, and gastrointestinal tract, but rarely the skeletal muscle. CASE PRESENTATION: An 82-year-old man presented with redness, swelling, and pain in his right lower limb for 3 months...
March 7, 2024: Current medical imaging
https://read.qxmd.com/read/38452514/epidermal-loss-of-bcl6-exacerbates-mc903-induced-atopic-dermatitis-like-skin-inflammation
#37
JOURNAL ARTICLE
Kaori Kanemaru, Kento Nagasawa, Yuta Kunugi, Asahi Tanaka, Shunsuke Ikeoku, Yuki Tai, Yohsuke Harada, Yoshikazu Nakamura
Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. In the lesional skin of AD, keratinocytes show differentiation defects and secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We previously reported that inducible loss of B-cell lymphoma 6 (Bcl6), a transcription repressor and a master transcriptional regulator of follicular helper T cells and germinal center B cells, in the whole body results in upregulation of Th2-related cytokines in mouse skin...
March 1, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38450476/immunobiology-and-treatment-of-cutaneous-t-cell-lymphoma
#38
REVIEW
Rishi R Goel, Alain H Rook
INTRODUCTION: Primary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders. AREAS COVERED: In this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome. EXPERT OPINION: Recent advances in immunology have provided new insights into the biology of malignant T cells...
March 7, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38449891/an-unusual-presentation-of-subcutaneous-panniculitis-like-t-cell-lymphoma-extensive-necrosis-and-hemophagocytic-lymphohistiocytosis-a-case-report
#39
Mehdi Loukhnati, Khaoula Khalil, Fatima Ezzahra Lahlimi, Illias Tazi
KEY CLINICAL MESSAGE: Subcutaneous panniculitis-like T-cell lymphoma, a primary cutaneous lymphoma, which is described as following a slow course, could claim life. The occurrence of facial and breast nodules, the association with hemophagocytic lymphohistiocytosis, and the extent of necrosis and ulceration are signs of its aggressive nature needing early diagnosis and prompt treatment. ABSTRACT: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare skin disease that accounts for <1% of all peripheral T-cell lymphomas...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38446533/satisfaction-and-effectiveness-of-switching-from-intravenous-to-subcutaneous-belimumab-treatment-in-daily-clinical-practice
#40
JOURNAL ARTICLE
Beatriz Frade-Sosa, Tarek Carlos Salman-Monte, Javier Narváez, Irene Peralta, Sebastian Sandoval, Berta Magallares, Sergi Heredia, Nuria Sapena, Anne Riveros-Frutos, Alejandro Olivé, Hector Corominas, Josefina Cortés-Hernández, José A Gómez-Puerta
BACKGROUND: In 2017, belimumab (BEL) was approved in subcutaneous (SQ) administration. The effectiveness after switching from intravenous (IV) to SQ and patient satisfaction in daily clinical practice has not been studied. During the pandemic, patient follow-up and treatment were significantly affected, and some patients need a change from IV to SQ. Our aim was to evaluate daily clinical practice satisfaction to SQ BEL therapy in patients previously treated IV BEL. We hypothesized that SQ BEL in SLE patients previously treated with IV BEL was similar in effectiveness and conferred higher satisfaction...
March 6, 2024: Lupus
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