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https://www.readbyqxmd.com/read/27880884/anti-atherosclerosis-and-cardio-protective-effects-of-the-angong-niuhuang-pill-on-a-high-fat-and-vitamin-d3-induced-rodent-model-of-atherosclerosis
#1
Wen-Juan Fu, Ting Lei, Zhen Yin, Jian-Hao Pan, Yu-Shuang Chai, Xiao-Yun Xu, Yi-Xi Yan, Zhi-Hua Wang, Jian Ke, Gang Wu, Ren-He Xu, Manish Paranjpe, Lintao Qu, Hong Nie
ETHNOPHARMACOLOGICAL RELEVANCE: The Angong Niuhuang Pill (ANP) is a well known Chinese traditional therapeutic for the treatment for diseases affecting the Central Nervous System (CNS). Components of the ANP formulation, including Bovis Calculus Sativus, Pulvis Bubali Comus Concentratus, Moschus, Margarita, Cinnabaris, Realgar, Coptidis Rhizoma, Scutellariae Radix, Gardeniae Fructus, Curcumae Radix, and Bomeolum Syntheticum, have been used for the treatment of stroke, encephalitis and emergency meningitis across Asia, especially in China for hundreds of years...
November 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27853367/caveolin-1-contributes-to-realgar-nanoparticle-therapy-in-human-chronic-myelogenous-leukemia-k562-cells
#2
Dan Shi, Yan Liu, Ronggang Xi, Wei Zou, Lijun Wu, Zhiran Zhang, Zhongyang Liu, Chao Qu, Baoli Xu, Xiaobo Wang
Chronic myelogenous leukemia (CML) is characterized by the t(9;22) (q34;q11)-associated Bcr-Abl fusion gene, which is an essential element of clinical diagnosis. As a traditional Chinese medicine, realgar has been widely used for the treatment of various diseases for >1,500 years. Inspired by nano-drug, realgar nanoparticles (NPs) have been prepared with an average particle size of <100 nm in a previous work. Compared with coarse realgar, the realgar NPs have higher bioavailability. As a principal constituent protein of caveolae, caveolin-1 (Cav-1) participates in regulating various cellular physiological and pathological processes including tumorigenesis and tumor development...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27730751/repression-of-microrna-372-by-arsenic-sulfide-inhibits-prostate-cancer-cell-proliferation-and-migration-through-regulation-of-lats2
#3
Hongwen Cao, Yigeng Feng, Lei Chen
As the main component of realgar, arsenic sulfide (As4 S4 ) contains anti-tumour activity by repressing cancer cell proliferation and migration in many tumours. However, the detailed mechanism of these processes is not clear yet. MicroRNAs (miRNAs) can function as tumour suppressor or oncogene based on their target mRNAs in different tumour tissues. Here, we found that As4 S4 could repress the over-expression of microRNA-372 (miR-372) in two prostate cancer cell lines and its over-expression promoted cell proliferation and migration...
October 12, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27720469/complete-removal-of-arsenic-and-zinc-from-a-heavily-contaminated-acid-mine-drainage-via-an-indigenous-srb-consortium
#4
Pierre Le Pape, Fabienne Battaglia-Brunet, Marc Parmentier, Catherine Joulian, Cindy Gassaud, Lidia Fernandez-Rojo, Jean-Michel Guigner, Maya Ikogou, Lucie Stetten, Luca Olivi, Corinne Casiot, Guillaume Morin
Acid mine drainages (AMD) are major sources of pollution to the environment. Passive bio-remediation technologies involving sulfate-reducing bacteria (SRB) are promising for treating arsenic contaminated waters. However, mechanisms of biogenic As-sulfide formation need to be better understood to decontaminate AMDs in acidic conditions. Here, we show that a high-As AMD effluent can be decontaminated by an indigenous SRB consortium. AMD water from the Carnoulès mine (Gard, France) was incubated with the consortium under anoxic conditions and As, Zn and Fe concentrations, pH and microbial activity were monitored during 94days...
September 28, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27668550/analytical-investigation-of-mud%C3%A3-jar-polychrome-on-the-carpentry-in-the-casa-de-pilatos-palace-in-seville-using-non-destructive-xrf-and-complementary-techniques
#5
M A Garrote, M D Robador, J L Perez-Rodriguez
The pigments, execution technique and repainting used on the polychrome wood ceilings and doors in the Casa de Pilatos (Seville, Spain) were studied using portable X-ray fluorescence equipment. Cross-sections of small samples were also analysed by optical microscopy, SEM with EDX analysis, micro-Raman and micro-infrared spectroscopy and X-ray diffraction. These carpentry works are magnificent examples of the Mudéjar art made in Spain in the early 16th century. Portable X-ray fluorescence gave good information on the different components of the polychrome...
September 20, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27663031/functional-characterization-and-unique-diversity-of-genes-and-microorganisms-involved-in-arsenite-oxidation-from-the-tailings-of-a-realgar-mine
#6
Xian-Chun Zeng, Guoji E, Jianing Wang, Nian Wang, Xiaoming Chen, Yao Mu, Hao Li, Ye Yang, Yichen Liu, Yanxin Wang
: The tailings of Shimen realgar mine have unique geochemical features. Arsenite oxidation is one of the major biogeochemical processes occurred in the tailings. However, little is known about the functional and molecular aspects of the microbial community involved in arsenite oxidation. Here, we fully explored the functional and molecular features of the microbial communities from the tailings of Shimen realgar mine. We collected six samples from the sites A, B, C, D, E and F of the tailings, respectively...
September 23, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27412851/effects-of-realgar-on-gsh-synthesis-in-the-mouse-hippocampus-involvement-of-system-xag-system-xc-mrp-1-and-nrf2
#7
Yanlei Wang, Mo Chen, Yinghua Zhang, Taoguang Huo, Ying Fang, Xuexin Jiao, Mingmei Yuan, Hong Jiang
Realgar is a type of mineral drug that contains arsenic and has neurotoxicity. Glutathione (GSH), which is the main antioxidant in the central nervous system, plays a key role in antioxidant defenses and the detoxification of arsenic. However, whether realgar interferes with the synthesis of GSH in the brain and the molecular mechanisms underlying its effects are largely unknown. Here, we used mouse models of exposure to realgar to show that realgar affects the synthesis of GSH in the hippocampus, leading to ultrastructural changes in hippocampal neurons and synapses and deficiencies in cognitive abilities, and that the mechanisms that cause this effect may be associated with alterations in the expression of system XAG(-), system XC(-), multidrug resistance-associated protein 1(MRP-1), nuclear factor E2-related factor 2 (Nrf2), γ-glutamylcysteine synthetase (γ-GCS), and the levels of glutamate (Glu) and cysteine (Cys) in the extracellular fluid...
October 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27383126/fabrication-of-water-soluble-polymer-encapsulated-as4s4-to-increase-oral-bioavailability-and-chemotherapeutic-efficacy-in-aml-mice
#8
Qiang Ma, Chuan Wang, Xiaojin Li, Hua Guo, Jie Meng, Jian Liu, Haiyan Xu
Realgar (As4S4) has been demonstrated to be effective for the treatment of acute myeloid leukemia (AML); it has the advantages of no drug resistance and oral administration. Nevertheless, its poor solubility has been an obstacle to its bioavailability, requiring high-dose administration over a long period. We investigated whether crushing realgar crystals to the nanoscale and encapsulating the particles in a water-soluble polymer in one step using hot-melt extrusion would increase the bioavailability of As4S4...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27377338/-1-hnmr-based-metabonomic-study-of-sub-chronic-hepatotoxicity-induced-by-realgar
#9
Taoguang Huo, Ying Fang, Longshan Zhao, Zhili Xiong, Yinghua Zhang, Yanlei Wang, Cong Feng, Mingmei Yuan, Shouyun Wang, Mo Chen, Hong Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: Realgar has been used as a traditional Chinese medicine (TCM) for thousands of years. Recently, a number of realgar or realgar-containing medicines poisoning cases have been reported. However, the toxicological mechanism of realgar has not been clearly clarified. In present study, the subchronic hepatotoxicity of realgar on mice was investigated using (1)HNMR-based metabonomic approaches. MATERIALS AND METHODS: Twenty-eight male mice were divided into control group and low (0...
July 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27322078/bayesian-network-meta-analysis-comparing-five-contemporary-treatment-strategies-for-newly-diagnosed-acute-promyelocytic-leukaemia
#10
Fenfang Wu, Di Wu, Yong Ren, Chongyang Duan, Shangwu Chen, Anlong Xu
Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. The optimum regimen for newly diagnosed APL remains inconclusive. In this Bayesian network meta-analysis, we compared the effectiveness of five regimens-arsenic trioxide (ATO) + all-trans retinoic acid (ATRA), realgar-indigo naturalis formula (RIF) which contains arsenic tetrasulfide + ATRA, ATRA + anthracycline-based chemotherapy (CT), ATO alone and ATRA alone, based on fourteen randomized controlled trials (RCTs), which included 1407 newly diagnosed APL patients...
June 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27097602/unexpected-reactivity-of-%C3%AE-5-1-2-4-tbu3-c5-h2-ni-%C3%AE-3-p3-towards-main-group-nucleophiles-and-by-reduction
#11
Eric Mädl, Gábor Balázs, Eugenia V Peresypkina, Manfred Scheer
The reduction of [Cp'''Ni(η(3) -P3 )] (1; Cp'''=η(5) -1,2,4-tBu3 C5 H2 ) with potassium produces the complex anion [(Cp'''Ni)2 (μ,η(2:2) -P8 )](2-) (2), which contains a realgar-like P8 unit. The anionic triple-decker sandwich complex [(Cp'''Ni)2 (μ,η(3:3) -P3 )](-) (3) with a cyclo-P3 middle deck is obtained when 1 is treated with NaNH2 as a nucleophile. Na[3] can subsequently be oxidized with AgOTf to the neutral triple-decker complex [(Cp'''Ni)2 (μ,η(3:3) -P3 )] (4). In contrast, 1 reacts with LiPPh2 to give the anionic compound [(Cp'''Ni)2 (μ,η(2:2) -P6 PPh2 )](-) (5), a complex containing a bicyclic P7 fragment capped by two Cp'''Ni units...
June 27, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27060218/assessment-of-arsenic-speciation-and-bioaccessibility-in-mine-impacted-materials
#12
Cameron J Ollson, Euan Smith, Kirk G Scheckel, Aaron R Betts, Albert L Juhasz
Mine-impacted materials were collected from Victoria, Australia and categorized into three source materials; tailings (n=35), calcinated (n=10) and grey slimes (n=5). Arsenic (As) concentrations in these materials varied over several orders of magnitude (30-47,000mgkg(-1)), with median concentrations of 500, 10,800 and 1500mgkg(-1), respectively. When As bioaccessibility was assessed using the Solubility Bioaccessibility Research Consortium (SBRC) assay, As bioaccessibility ranged between 4 and 90%, with mean gastric phase values of 30%, 49% and 82% for tailings, calcinated and grey slimes, respectively...
August 5, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27039309/effects-of-glycyrrhetinic-acid-on-gsh-synthesis-induced-by-realgar-in-the-mouse-hippocampus-involvement-of-system-formula-see-text-system-formula-see-text-mrp-1-and-nrf2
#13
Yan-Lei Wang, Mo Chen, Tao-Guang Huo, Ying-Hua Zhang, Ying Fang, Cong Feng, Shou-Yun Wang, Hong Jiang
Realgar, a type of mineral drug-containing arsenic, exhibits neurotoxicity. Brain glutathione (GSH) is crucial to protect the nervous system and to resist arsenic toxicity. Therefore, the main aim of this study was to explore the neurotoxic mechanisms of realgar and the protective effects of glycyrrhetinic acid (GA) by observing the effects of GA on the hippocampal GSH biosynthetic pathway after exposure to realgar. Institute of Cancer Research (ICR) mice were randomly divided into five groups: a control group, a GA control group, a realgar alone group, a low-dose GA intervention group, and a high-dose GA intervention group...
April 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26924273/synthesis-and-structural-characterization-of-magnesium-substituted-polystibides-lmg-4sb8
#14
Chelladurai Ganesamoorthy, Christoph Wölper, Anton S Nizovtsev, Stephan Schulz
Redox reactions of [(L(1,2) Mg)2 ] and Sb2 R4 (R=Me, Et) yielded the first Mg-substituted realgar-type Sb8 polystibides [(L(1,2) Mg)4 (μ4 ,η(2:2:2:2) -Sb8)] (L(1) =HC[C(Me)N(2,4,6-Me3 C6 H2)]2, L(2) =HC[C(Me)N(2,6-i-Pr2 C6 H3)]2). Compounds [(L(1,2) Mg)2] serve both as reducing agents, initiating the cleavage of the Sb-C bonds, and as stabilizers for the resulting Sb8 polyanion. The polystibides were characterized by NMR and IR spectroscopies, elemental analysis, and X-ray structure analysis. In addition, results from quantum chemical calculations are presented...
March 18, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/26899650/the-molecular-diversity-of-arbuscular-mycorrhizal-fungi-in-the-arsenic-mining-impacted-sites-in-hunan-province-of-china
#15
Yuqing Sun, Xin Zhang, Zhaoxiang Wu, Yajun Hu, Songlin Wu, Baodong Chen
Arbuscular mycorrhizal fungi (AMF) can establish a mutualistic association with most terrestrial plants even in heavy metal contaminated environments. It has been documented that high concentrations of toxic metals, such as arsenic (As) in soil could adversely affect the diversity and function of AMF. However, there are still gaps in understanding the community composition of AMF under long-term As contaminations. In the present study, six sampling sites with different As concentrations were selected in the Realgar mining area in Hunan Province of China...
January 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/26685413/-one-case-of-a-pregnant-femal-taking-realgar-induceing-congenital-inner-ear-malformation
#16
Mingfang Diao, Jianjun Sun, Yang Liu
A pregnant female taken realgar because of superstition, which caused the baby congenital deafness. Auditory test indicated that bilateral auditory brainstem response (ABR) hearing threshold level was greater than 90 dB nHL and auditory steady state response (ASSR) hearing level ranging from 0.5 kHz to 4 kHz was beyond 110 dB HL. Temporal bone CT showed that bilateral cochlear and semicircular canal malformations, with internal auditory canal broadened.
August 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26653746/determination-of-20-trace-elements-and-arsenic-species-for-a-realgar-containing-traditional-chinese-medicine-niuhuang-jiedu-tablets-by-direct-inductively-coupled-plasma-mass-spectrometry-and-high-performance-liquid-chromatography-inductively-coupled-plasma
#17
Pengfei Jin, Xiaoli Liang, Lufeng Xia, Farid Jahouh, Rong Wang, Yongmei Kuang, Xin Hu
Niuhuang Jiedu tablet (NHJDT) is a realgar-containing traditional Chinese medicine. A direct inductively coupled plasma-mass spectrometry (ICP-MS) method for the simultaneous determination of 20 trace elements (Mg, K, Ca, Na, Fe, As, Zn, Sr, Ba, Cu, Mn, Ni, Pb, V, Cr, Se, Co, Mo, Cd, Hg) in NHJDT, as well as in water, gastric fluid and intestinal fluid was established. Meanwhile, a high performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) method was developed for the determination of arsenite (As(III)), arsenate (As(V)), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and for the identification of arsenobetaine (AsB) and arsenocholine (AsC) in these extracts...
January 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/26622649/long-term-outcome-of-31-cases-of-refractory-acute-promyelocytic-leukemia-treated-with-compound-realgar-natural-indigo-tablets-administered-alternately-with-chemotherapy
#18
Yanfeng Liu, Pengcheng He, Xiaoyan Cheng, Mei Zhang
The aim of the present study was to investigate the long-term survival of patients with refractory acute promyelocytic leukemia (APL) that were administered alternately with compound realgar natural indigo tablet (CRNIT) treatment and chemotherapy. In total, 31 patients with refractory APL were administered with CRNIT treatment alternately with chemotherapy. The complete remission (CR) and relapse rates were estimated by bone marrow (BM) examination. The expression of the promyelocytic leukemia-retinoic acid receptor α (PML-RARα) fusion protein and the apoptosis rate in the retinoic acid (RA)-resistant NB4-R1 cell line administered with CRNIT treatment in vitro were measured by western blot analysis and flow cytometry, respectively...
August 2015: Oncology Letters
https://www.readbyqxmd.com/read/26541839/-effect-of-nano-realgar-on-proliferation-and-apoptosis-of-human-cervical-carcinoma-cells
#19
Lijie Li, Luying Wang, Songshu Xiao, Yueran Li, Chunxia Cheng, Min Xue
OBJECTIVE: To investigate the effect of nano-realgar on proliferation and apoptosis of cervical cancer cells.
 METHODS: Different cervical cancer cell lines (Caski/HPV16+, adeno carcinoma; Hela/HPV18+, squmous carcinoma; C33A/HPV-, adeno carcinoma) were incubated with nano-realgar at different concentrations (5, 10, 20, 40 mg/L) for different times (24, 48, 72, 96 h). The morphology was observed under phase contrast microscope. The cell viability and apoptosis were examined by MTT and flow cytometry, respectively...
October 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/26405541/realgar-quantum-dots-induce-apoptosis-and-necrosis-in-hepg2-cells-through-endoplasmic-reticulum-stress
#20
Y U Qin, Huan Wang, Zheng-Yun Liu, Jie Liu, Jin-Zhu Wu
Realgar (As4S4) has been used in traditional Chinese medicines for treatment of malignancies. However, the poor water solubility of realgar limits its clinical application. To overcome this problem, realgar quantum dots (RQDs; 5.48±1.09 nm) were prepared by a photoluminescence method. The mean particle size was characterized by high-resolution transmission electron microscopy and scanning electron microscopy. Our recent studies revealed that the RQDs were effective against tumor growth in tumor-bearing mice without producing apparent toxicity...
September 2015: Biomedical Reports
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