Moritz Weigl, Teresa L Krammer, Marianne Pultar, Matthias Wieser, Selim Chaib, Masayoshi Suda, Andreas Diendorfer, Kseniya Khamina-Kotisch, Nino Giorgadze, Tamar Pirtskhalava, Kurt O Johnson, Christina L Inman, Ailing Xue, Ingo Lämmermann, Barbara Meixner, Lichao Wang, Ming Xu, Regina Grillari, Mikolaj Ogrodnik, Tamar Tchkonia, Matthias Hackl, James L Kirkland, Johannes Grillari
In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into clinical trials, creating an unmet need for minimally invasive biomarkers of senescent cell load to identify patients at need for senotherapy. We created a landscape of miRNA and mRNA expression in five human cell types induced to senescence in-vitro and provide proof-of-principle evidence that miRNA expression can track senescence burden dynamically in-vivo using transgenic p21 high senescent cell clearance in HFD fed mice...
April 10, 2024: bioRxiv