keyword
MENU ▼
Read by QxMD icon Read
search

(age OR aging OR ageing) AND tissue

keyword
https://www.readbyqxmd.com/read/29457783/cellular-senescence-in-brain-aging-and-neurodegenerative-diseases-evidence-and-perspectives
#1
Darren J Baker, Ronald C Petersen
Along with a general decline in overall health, most chronic degenerative human diseases are inherently associated with increasing age. Age-associated cognitive impairments and neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases, are potentially debilitating conditions that lack viable options for treatment, resulting in a tremendous economic and societal cost. Most high-profile clinical trials for neurodegenerative diseases have led to inefficacious results, suggesting that novel approaches to treating these pathologies are needed...
February 19, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29457655/importance-of-growth-rate-on-hg-and-pcb-bioaccumulation-in-fish
#2
Jiajia Li, G Douglas Haffner, Gordon Paterson, David M Walters, Michael D Burtnyk, Ken G Drouillard
To evaluate the effect of fish growth on mercury (Hg) and polychlorinated biphenyls (PCBs) bioaccumulation, a non-steady state toxicokinetic model, combined with a Wisconsin bioenergetics model, was developed to simulate Hg and PCB bioaccumulation in Bluegill (Lepomis macrochirus). The model was validated by comparing observed versus predicted Hg and PCB 180 concentrations across 5 age classes from five different waterbodies across North America. The non-steady state model generated accurate predictions for Hg and PCB bioaccumulation in three of five waterbodies: Apsey, Sharbot and Stonelick Lake...
February 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29457439/-antero-medial-incision-of-knee-joint-for-the-treatment-of-intercondylar-fracture-of-femur
#3
Zi-Fei Yin, Bin-Feng Sun, Xiao-Hai Yang, Qing Wang, Ping-Kang Qian, Xiao-Feng Wu, Feng Xu
OBJECTIVE: To explore the clinical effect of antero-medial incision of knee joint in treating intercondylar fracture of femur. METHODS: From September 2012 to March 2015, 24 patients with intercondylar fracture of femur were selected, including 17 males and 7 females, aged from 20 to 65 years old with an average of(38.3±9.5) years old. Among them, 12 cases were caused by traffic accident, 8 cases were caused by falling injury and 4 cases were caused by falling down...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457437/-clinical-application-value-of-mri-on-malignant-fibrous-histiocytoma-in-soft-tissue
#4
Wan-Li Xu, Xiao Wu, Hai-Feng Qian, Dong Liu
OBJECTIVE: To investigate imaging manifestation and clinical application of MRI on malignant fibrous histiocytoma (MFH) in soft tissue. METHODS: Imaging and pathological data of 16 patients with malignant fibrous histiocytoma (MFH) in soft tissue confirmed by surgery and pathology were retrospectively analyzed from January 2009 to August 2016. There were 9 males and 7 females, aged from 34 to 67 years old with an average of 52 years. The courses of disease ranged from 5 to 48 months with an average of 27 months...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457436/-clinical-application-of-tibial-composite-saphenous-nervetissue-flap-for-the-treatment-of-traumatic-bone-skin-defect-of-leg
#5
Zhi-Wei Zhao, Wen-Jing Liu, Zhu-Qing Zha, Yan-Feng Li, Hui-Jun Fan
OBJECTIVE: To investigate the effect of tibial composite saphenous nerve tissue flap in repairing traumatic bone-skin defect of leg. METHODS: From February 2009 to May 2015, 23 patients with focile skin defect caused by trauma were treated, including 18 males and 5 females, aged from 8 to 59 years old with an average age of 35.6 years old. Length of tibia bone cortex defect ranged from 4 to 12 cm, width ranged from 2 to 2.5cm, skin defect ranged from 8 cm× 3 cm to 18 cm× 11 cm, all the wound surfaces had purulent exudation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457435/-repair-soft-tissue-defect-in-forefoot-with-reversed-lateral-soleus-muscle-flap
#6
Gong-Lin Zhang, Ping Zhen, Ke-Ming Chen, Lai-Xu Zhao, Jun-Lin Yang, Jan-Hua Zhou, Qin-Yi Xue
OBJECTIVE: To summarize clinical application results of repair soft tissue defect in forefoot with a reversed lateral soleus muscle flap on peroneal artery pedicle. METHODS: From January 2005 to January 2013, 8 patients with soft-tissue defect on forefoot were underwent reconstruction with a reversed lateral soleus muscle flap on peroneal artery pedicle. There were 6 males and 2 female, aged from 16 to 48 years with an average of 26.8 years old. The reversed lateral soleus muscle flap was transposed to the forefoot defect area, then immediate coverage of the muscle flaps were performed by a meshed split-thickness free skin graft...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457409/-analysis-of-risk-factors-of-infection-for-complex-tibial-plateau-fractures-after-operation
#7
Ju-Lei Ma, Yun-Qin Xu, Tu-Gang Shen, Qiang Li
OBJECTIVE: To analyze the risk factor of infection for complex tibial plateau fractures after operation. METHODS: Totally clinical data of 293 patients with complex tibial plateau fractures underwent open reduction and internal fixation were retrospectively analyzed from September 2010 to March 2015, including 199 males and 94 females, ranging in age from 17 to 80 years old with an average of 47.3 years old. The possible risk factors such as gender, age, smoking, diabetes, type of fracture(open/closed), classification of open fracture(Gustilo-Anderson classification), classification of soft tissue injury in closed fracture (Tscherne-Gotzen classification), fracture classification(Schatzker V/VI), osteofascial compartment syndrome, ASA score, anesthesia, timing of surgery, operative time(<=150 min/>150 min), surgical approach, combined approach or not, internal fixation site were studied...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457402/-clinical-study-on-negative-pressure-closed-drainage-combined-with-vancomycin-loaded-calcium-sulfate-and-autogenous-bone-in-the-treatment-of-chronic-osteomyelitis
#8
Qiang Li, Shi-Feng Song, Wei Zhang, Guo-Zhi Wu, Li-Zhu Liu
OBJECTIVE: To study the clinical effects of negative pressure closed drainage combined with vancomycin loaded calcium sulfate and autogenous bone in the treatment of chronic osteomyelitis. METHODS: From June 2013 to December 2016, there were 35 cases of chronic osteomyelitis patients in our department, including 23 males and 12 females, ranging in age from 11 to 65 years old, with an average of 34 years old. The course of disease ranged from 8 to 46 months, with an average of 26 months...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457302/innate-lymphoid-cells-at-the-human-maternal-fetal-interface-in-spontaneous-preterm-labor
#9
Yi Xu, Roberto Romero, Derek Miller, Pablo Silva, Bogdan Panaitescu, Kevin R Theis, Afrah Arif, Sonia S Hassan, Nardhy Gomez-Lopez
PROBLEM: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor. METHODS OF STUDY: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls...
February 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29457265/the-role-of-type-2-diabetes-mellitus-on-hypertensive-related-aortic-stiffness
#10
Edoardo Sciatti, Enrico Vizzardi, Assunta Castiello, Francesca Valentini, Ivano Bonadei, Sandro Gelsomino, Roberto Lorusso, Marco Metra
BACKGROUND: Hypertension is strongly related to arterial stiffness in a cause-effect fashion. Diabetes mellitus is also thought to determine vascular damage, mostly by means of advanced glycosylation end-products (AGEs). Aim of our study was to study the role of type 2 diabetes mellitus (T2DM) as regard ascending aortic elastic properties in hypertensive patients. METHODS: We prospectively enrolled outpatients with hypertension (n = 99) and type 2 diabetes mellitus plus hypertension (n = 42) without cardiovascular events...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29457119/effects-of-glucose-insulin-infusion-during-major-oral-and-maxillofacial-surgery-on-postoperative-complications-and-outcomes
#11
Akina Tohya, Atsushi Kohjitani, Sachi Ohno, Kaoru Yamashita, Yozo Manabe, Mitsutaka Sugimura
Background: Secretion of hormones, which antagonize the action of insulin, is facilitated in response to surgery, and acute resistance to the action of insulin develops. Our aim is to elucidate the effects of intraoperative glycemic control by glucose-insulin (GI) infusion on postoperative complications and outcomes in major oral and maxillofacial surgery. Findings: Thirty patients aged ≥ 60 years undergoing a radical operation of oral malignant tumors with tissue reconstruction (≥ 8 h) were analyzed...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#12
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456946/detection-of-epstein-barr-and-human-papilloma-viruses-in-the-middle-ear-squamous-cell-carcinoma
#13
Agus Surono, Bambang Hariwiyanto, Edhie Samodra
The uncommon ear tumor of middle ear squamous cell carcinoma (MESCC) is thought to be associated with the history of long-term chronic otitis media in the most cases. The main etiologic factor of MESCC is still unclear and may be multifactorial. Infections of Epstein-Barr virus (EBV) and Human Papillomavirus (HPV) are considered as one of the etiologic factor of MESCC. Previous studies have shown that the EBV and HPV have been detected in MESCC. Although the EBV and HPV have been implicated in human malignancies, their roles in pathogenesis of MESCC have not been elucidated...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456720/mir-494-inhibits-cervical-cancer-cell-proliferation-through-upregulation-of-socs6-expression
#14
Lei Cheng, Beihua Kong, Ying Zhao, Jie Jiang
It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the human cervical cancer HeLa cell line. The expression of miR-494 was determined using reverse transcription-quantitative polymerase chain reaction. In addition, TargetScan was used to predict miR-494 target genes and the luciferase reporter assay was used to determine whether SOCS6 was a direct target of miR-494...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456719/estrogen-receptor-%C3%AE-promoter-methylation-is-a-biomarker-for-outcome-prediction-of-cisplatin-resistance-in-triple-negative-breast-cancer
#15
Junnan Xu, Tao Sun, Xiangyu Guo, Yan Wang, Mingxi Jing
A number of previous studies have indicated the presence of a link between estrogen receptor-α (ERα) methylation and triple-negative breast cancer (TNBC). However, the association between ERα methylation and drug resistance during the treatment of TNBC remains unclear. Methylation-specific polymerase chain reaction was used to investigate the methylation of ERα in the genomic DNA of 35 patients with TNBC who were defined as cisplatin-based chemotherapy-resistant using chemosensitivity testing. Survival probabilities by covariates were assessed using Kaplan-Meier estimator survival analysis and Cox's proportional hazards models, adjusting for age, menopausal status, tumor size, lymph node metastasis and ERα promoter DNA methylation...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456303/impact-of-nonsurgical-periodontal-therapy-on-total-antioxidant-capacity-in-chronic-periodontitis-patients
#16
Neha Bansal, Narender Dev Gupta, Afshan Bey, Vivek Kumar Sharma, Namita Gupta, Himanshu Trivedi
Aim: The aim of this study was to determine the utility of plasma total antioxidant capacity (TAC) as marker of periodontal disease by estimating TAC of periodontally healthy and chronic periodontitis patients and the impact of scaling and root planning on total antioxidant status of periodontitis patients. Materials and Methods: Blood plasma samples were collected from randomly selected eighty individuals (40 periodontally healthy controls and 40 chronic periodontitis patients), with an age range of 20-45 years and were analyzed for TAC by ferric reducing antioxidant power assay...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29456223/knowledge-and-attitude-toward-organ-donation-among-people-in-lanja-a-rural-town-in-india
#17
Vaishaly K Bharambe, Vasanti U Arole, Vatsalaswamy Puranam, Preeti P Kulkarni, Prashant B Kulkarni
Organ shortage is the greatest challenge facing the field of organ transplantation today. We aimed to study the attitude and knowledge toward body and organ donation among people in rural India. The present study was conducted in a rural town called Lanja, in the Konkan region of Maharashtra in India. A questionnaire covering demographic data, knowledge, and attitude of the participants was distributed to 400 students, middle-aged and senior citizens; 91.5% of the respondents were aware about organ donation...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455879/transient-and-regional-ischemia-related-to-continuous-saline-solution-infusion-during-radial-artery-access
#18
Nicholas Xiao, Jonathan Lindquist, Robert L Vogelzang
This case series illustrates a radial access complication seen in 7 of 9 consecutive patients (age range, 44-53 y) undergoing uterine artery embolization in May and June 2017. Demonstrative images and videos identify a transient and clinically consequential skin ischemia caused by intraprocedural saline solution infusion through the occlusive radial artery sheath. All complications documented were classified as mild adverse events (class A) according to Society of Interventional Radiology criteria. Complication severity ranged from transient blanching to ischemic necrosis of the skin...
March 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29455631/periosteal-flap-augmentation-of-the-modified-brostr%C3%A3-m-gould-procedure-for-chronic-lateral-ankle-instability
#19
Chee Ping Chew, Kevin Oon Thien Koo, Denny Tjiauw Tjoen Lie
INTRODUCTION: Chronic lateral ankle instability occurs in up to 20% of ankle injuries. Most can be treated conservatively, but surgical reconstruction is required if conservative treatment fails. Modified Broström-Gould procedure is an effective surgical treatment and the augmentation of this procedure with a periosteal flap may confer additional stability. We report on the outcome of a technique combining a modified Broström-Gould procedure augmented with a periosteal flap in patients with chronic lateral ankle instability...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29455533/effect-of-dietary-protein-level-on-the-expression-of-proteins-in-the-gastrointestinal-tract-of-young-pigs
#20
Xianyong Ma, Xianyong Ma, Zhimei Tian, Dun Deng, Yiyan Cui, Yueqin Qiu
The objective of this research is to investigate the effect of protein level on proteins expression in the gastrointestinal tract of young pigs. Eighteen piglets (Duroc×Landrace×Yorkshire) were weaned at 28 days of age and randomly assigned to 3 diets with 20%, 17%, and 14% CP level and four essential AA: Lys, Met, Thr and Trp in three diets meet the requirements of weaned piglets. The experimental period lasts 45d. RESULTS: Compared with the control (20% CP level), the average daily feed intake, the average daily gain and gain feed ratio of the 17% CP group did not decrease (P > 0...
February 17, 2018: Journal of Agricultural and Food Chemistry
keyword
keyword
81355
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"