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https://www.readbyqxmd.com/read/29236391/age-related-changes-phospholipids-of-sterlet-in-liver-and-dorsal-muscles
#1
R R Suleimanova, E A Hudz, D O Melnychuk, L H Kalachniuk
Study of phospholipids changes peculiarities in the liver and dorsal muscles of sterlet (Acipenser ruthenus Linnaeus) may be important to determine the etiology and pathogenesis of fatty liver. We established that the content of total phospholipids in tissues of the liver and dorsal muscles of three-year-old sterlet was less than for two-year-old fish by 15% and 20% (P ≤ 0.01), respectively. The amount of phosphatidylcholine (P ≤ 0.05), phosphatidylethanolamine, phosphatidylserine (P ≤ 0.01), phosphatidylinositol (P ≤ 0...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236276/5-ht7-receptors-are-over-expressed-in-patients-with-nasal-polyps
#2
Muhammed Yayla, Zekai Halici, Duygu Kose, Arzu Tatar, Mustafa Sitki Gozeler
Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control). The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236205/a-novel-fibrin-based-artificial-ovary-prototype-resembling-human-ovarian-tissue-in-terms-of-architecture-and-rigidity
#3
Maria Costanza Chiti, Marie-Madeleine Dolmans, Lucie Mortiaux, Flanco Zhuge, Emna Ouni, Parinaz Asiabi Kohneh Shahri, Evelyne Van Ruymbeke, Sophie-Demoustier Champagne, Jacques Donnez, Christiani Andrade Amorim
PURPOSE: The aim of this study is to optimize fibrin matrix composition in order to mimic human ovarian tissue architecture for human ovarian follicle encapsulation and grafting. METHODS: Ultrastructure of fresh human ovarian cortex in age-related women (n = 3) and different fibrin formulations (F12.5/T1, F30/T50, F50/T50, F75/T75), rheology of fibrin matrices and histology of isolated and encapsulated human ovarian follicles in these matrices. RESULTS: Fresh human ovarian cortex showed a highly fibrous and structurally inhomogeneous architecture in three age-related patients, but the mean ± SD of fiber thickness (61...
December 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29236161/genetic-analysis-of-adults-heterozygous-for-alpl-mutations
#4
Agnès Taillandier, Christelle Domingues, Annika Dufour, Françoise Debiais, Pascal Guggenbuhl, Christian Roux, Catherine Cormier, Bernard Cortet, Valérie Porquet-Bordes, Fabienne Coury, David Geneviève, Jean Chiesa, Thierry Colin, Elaine Fletcher, Agnès Guichet, Rose-Marie Javier, Michel Laroche, Michael Laurent, Ekkehart Lausch, Bruno LeHeup, Cédric Lukas, Georg Schwabe, Ineke van der Burgt, Christine Muti, Brigitte Simon-Bouy, Etienne Mornet
Hypophosphatasia (HPP) is a rare inherited metabolic bone disease due to a deficiency of the tissue nonspecific alkaline phosphatase isoenzyme (TNSALP) encoded by the ALPL gene. Patients have consistently low serum alkaline phosphatase (AP), so that this parameter is a good hallmark of the disease. Adult HPP is heterogeneous, and some patients present only mild nonpathognomonic symptoms which are also common in the general population such as joint pain, osteomalacia and osteopenia, chondrocalcinosis, arthropathy and musculoskeletal pain...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29235262/corrugated-bruch-s-membrane-in-high-myopia
#5
Jost B Jonas, Rahul A Jonas, Kyoko Ohno-Matsui, Leonard Holbach, Songhomitra Panda-Jonas
PURPOSE: To assess the appearance of Bruch's membrane (BM) in axially elongated eyes. METHODS: The light-microscopical investigation included histological anterior-posterior sections of human eyes. Using a light microscope, we assessed whether BM in the posterior segment was straight or locally corrugated. Corrugation of BM was defined as an elevation of BM with a height >20 μm over a basis of 50 μm without collateral proliferations of retinal pigment epithelium or choroidal swelling...
December 13, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29235194/dual-sensitivity-multiple-sclerosis-lesion-and-csf-segmentation-for-multichannel-3t-brain-mri
#6
Dominik S Meier, Charles R G Guttmann, Subhash Tummala, Nicola Moscufo, Michele Cavallari, Shahamat Tauhid, Rohit Bakshi, Howard L Weiner
BACKGROUND AND PURPOSE: A pipeline for fully automated segmentation of 3T brain MRI scans in multiple sclerosis (MS) is presented. This 3T morphometry (3TM) pipeline provides indicators of MS disease progression from multichannel datasets with high-resolution 3-dimensional T1-weighted, T2-weighted, and fluid-attenuated inversion-recovery (FLAIR) contrast. 3TM segments white (WM) and gray matter (GM) and cerebrospinal fluid (CSF) to assess atrophy and provides WM lesion (WML) volume. METHODS: To address nonuniform distribution of noise/contrast (eg, posterior fossa in 3D-FLAIR) of 3T magnetic resonance imaging, the method employs dual sensitivity (different sensitivities for lesion detection in predefined regions)...
December 13, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29235037/expression-and-significance-of-cytokeratin-7-a-squamocolumnar-junction-marker-in-head-and-neck-squamous-cell-carcinoma
#7
Mitra Mehrad, William D Dupont, W Dale Plummer, James S Lewis
The favorable features of high-risk human papillomavirus (HPV) in the head and neck are limited to those harboring transcriptionally-active HPV, which occur predominantly in the oropharynx (OP). Factors rendering the OP susceptible to HPV oncogenesis are largely unexplored. The role of cytokeratin 7 (CK7) in predisposition to HPV and cancer in the cervix has been evaluated. However, its significance in the H&N is unknown. CK7 immunohistochemistry was performed on a tissue microarray cohort of OP and non-oropharyngeal (NOP) squamous cell carcinomas (SCC) with known clinical follow-up and HPV E6/7 mRNA status...
December 12, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29234911/increased-dot1l-in-synovial-biopsies-of-patients-with-oa-and-ra
#8
Dongyi He, Jia Liu, Yamei Hai, Qi Zhu, Yu Shen, Shicheng Guo, Wenzheng Zhang, Xiaodong Zhou
The studies aimed to determine the changes of histone methylation in synovial tissues of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Synovial tissues were obtained from 30 patients including 12 OA, 16 RA, and 2 trauma that were used as control. A histone methyltransferase DOT1L of the tissues was examined for transcript level with quantitative RT-PCR and protein expression with western blot. Methylation status of DOT1L substrate, H3K79, was examined with immunohistochemistry and western blot...
December 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29234894/amputation-neuroma-mimicking-lymph-node-metastasis-of-remnant-gastric-cancer-a-case-report
#9
Kenichiro Furukawa, Yutaka Tanizawa, Kimihide Kusafuka, Noriyuki Nishiwaki, Keiichi Fujiya, Hayato Omori, Sanae Kaji, Makoto Hikage, Rie Makuuchi, Tomoyuki Irino, Masanori Tokunaga, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: Amputation neuromas (ANs) are reactive hyperplasia of nerve tissues that occur after a trauma or surgery involving the peripheral nerves. Only two previous reports of ANs occurring around the stomach and post gastrectomy have been reported. We report the case of a patient with AN near the remnant stomach who underwent distal gastrectomy for gastric cancer. CASE PRESENTATION: A 76-year-old man underwent distal gastrectomy, D1+ lymphadenectomy, and Billroth-I reconstruction for early gastric cancer in another hospital at 63 years of age...
December 12, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29234609/outcomes-of-open-repair-of-mycotic-aortic-aneurysms-with-in-situ-replacement
#10
Hyo-Hyun Kim, Do Jung Kim, Hyun-Chel Joo
Background: Mycotic aortic aneurysms are rare and life-threatening. Unfortunately, no established guidelines exist for the treatment of patients with mycotic aortic aneurysms. The purpose of this study was to evaluate the midterm outcomes of the open repair of mycotic thoracic and thoracoabdominal aneurysms and suggest a therapeutic strategy. Methods: From 2006 to 2016, 19 patients underwent open repair for an aortic aneurysm. All infected tissue was extensively debrided and covered with soft tissue...
December 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29234568/long-term-quality-of-life-of-retroperitoneal-sarcoma-patients-treated-with-pre-operative-radiotherapy-and-surgery
#11
Philip Wong, Zahra Kassam, Amanda N Springer, Rebecca Gladdy, Peter Chung, Jolie Ringash, Charles Catton
PURPOSE: Retroperitoneal sarcomas (RPS) are connective tissue cancers that are often large and anatomically in close proximity to critical and radiation-sensitive normal structures and organs within the abdomen and pelvis. The management of RPS may include preoperative radiotherapy (RT) and surgery. We aimed to examine how treatment-related toxicities affect patient quality of life (QOL).  Methods and materials: Within two prospective cohort studies, 48 RPS patients who were treated with preoperative RT from 1998-2012 were recruited and assessed for QOL (EORTC-QLQ-C30) and to determine toxicities potentially related to RT and surgery (graded using CTCAE V...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29233704/risk-factors-for-post-operative-complications-after-procedures-for-autologous-bone-augmentation-from-different-donor-sites
#12
Andreas Sakkas, Alexander Schramm, Karsten Winter, Frank Wilde
AIM: The aim of this study has been to identify risk factors for post-operative complications after grafting bone from different donor sites prior to implant placement. MATERIAL AND METHODS: The study encompassed 279 patients who underwent autologous bone augmentations in a 2-stage procedure, harvested from three intraoral and one extraoral donor sites, as well as sinus floor elevations prior to implant placement. The following complications were recorded: soft tissue dehiscence; wound infection; bone graft exposure; sensory disturbance; sinusitis symptoms; haemorrhage; graft failure; implant failure...
November 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233698/ex-corpore-linguae-a-cohort-analysis-after-a-unique-surgical-technique-in-oral-cancer-resection
#13
Jan-Falco Wilbrand, Daniel Schmermund, Michael Knitschke, Philipp Streckbein, Christopher Kähling, Heiko Kerkmann, Heidrun Schaaf, Hans-Peter Howaldt, Sebastian Böttger
OBJECTIVE: Resection of posteriorly located oral squamous cell carcinomas (OSCCs) remains challenging for head and neck surgeons. However, several surgical techniques, such as lip and mandibular splitting, as well as submental "visor drop-down" of intraoral soft tissues, have been proposed for this purpose. Merrick et al. suggested that a pedicled genial drop-down surgical approach should be used to resect dorsally located OSCCs. Our study investigated patient outcomes following this surgical procedure, as no previous study has analyzed long-term follow-up data...
November 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233634/epicardial-adipose-tissue-density-and-volume-are-related-to-subclinical-atherosclerosis-inflammation-and-major-adverse-cardiac-events-in-asymptomatic-subjects
#14
Markus Goeller, Stephan Achenbach, Mohamed Marwan, Mhairi K Doris, Sebastien Cadet, Frederic Commandeur, Xi Chen, Piotr J Slomka, Heidi Gransar, J Jane Cao, Nathan D Wong, Moritz H Albrecht, Alan Rozanski, Balaji K Tamarappoo, Daniel S Berman, Damini Dey
BACKGROUND: We investigated whether epicardial adipose tissue (EAT) volume and density are related to early atherosclerosis, plaque inflammation and major adverse cardiac events (MACE, cardiac death and myocardial infarction) in asymptomatic subjects. METHODS: EAT volume and density were quantified from non-contrast cardiac CT in 456 asymptomatic individuals (age 60.3 ± 8.3; 68% with CCS>0) from the prospective EISNER trial. EAT volume and density were examined in relation to coronary calcium score (CCS), inflammatory biomarkers and MACE...
November 24, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29233593/anterior-mediastinal-tissue-volume-is-correlated-with-antiacetylcholine-receptor-antibody-level-in-myasthenia-gravis
#15
Akihiro Takahagi, Mitsugu Omasa, Toyofumi F Chen-Yoshikawa, Masatsugu Hamaji, Akihiko Yoshizawa, Takashi Sozu, Makoto Sonobe, Hiroshi Date
OBJECTIVES: Extended thymectomy is a treatment option for myasthenia gravis (MG), but the surgical indications are controversial. Pathologic features of the thymus can be used to predict surgical outcomes, but there is no reliable method for evaluating these characteristics preoperatively. The purpose of this study was to determine whether anterior mediastinal tissue volume, as measured via 3-dimensional computed tomography (3DCT) volumetry, correlates with serum anti-acetylcholine receptor antibody (AChRAb) levels in patients undergoing thymectomy for myasthenia gravis...
November 8, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29233126/positive-prognostic-value-of-her2-her3-co-expression-and-p-mtor-in-gastric-cancer-patients
#16
Guo-Dong Cao, Ke Chen, Bo Chen, Mao-Ming Xiong
BACKGROUND: The HER2-HER3 heterodimer significantly decreases survival in breast cancer patients. However, the prognostic value of HER2-HER3 overexpression remains unknown in gastric cancer (GC). METHODS: The expression levels of HER2, HER3, Akt, p-Akt, mTOR and p-mTOR were examined in specimens from 120 GC patients by immunohistochemistry and quantitative reverse transcription-PCR. The associations of HER proteins, PI3K/Akt/mTOR pathway-related proteins, clinicopathological features of GC, and overall survival (OS) were assessed...
December 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29232896/dietary-animal-plasma-proteins-improve-the-intestinal-immune-response-in-senescent-mice
#17
Lluïsa Miró, Alba Garcia-Just, Concepció Amat, Javier Polo, Miquel Moretó, Anna Pérez-Bosque
Increased life expectancy has promoted research on healthy aging. Aging is accompanied by increased non-specific immune activation (inflammaging) which favors the appearance of several disorders. Here, we study whether dietary supplementation with spray-dried animal plasma (SDP), which has been shown to reduce the activation of gut-associated lymphoid tissue (GALT) in rodents challenged by S. aureus enterotoxin B (SEB), and can also prevent the effects of aging on immune system homeostasis. We first characterized GALT in a mouse model of accelerated senescence (SAMP8) at different ages (compared to mice resistant to accelerated senescence; SAMR1)...
December 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29232702/adipose-tissue-deficiency-of-hormone-sensitive-lipase-causes-fatty-liver-in-mice
#18
Bo Xia, Guo He Cai, Hao Yang, Shu Pei Wang, Grant A Mitchell, Jiang Wei Wu
Fatty liver is a major health problem worldwide. People with hereditary deficiency of hormone-sensitive lipase (HSL) are reported to develop fatty liver. In this study, systemic and tissue-specific HSL-deficient mice were used as models to explore the underlying mechanism of this association. We found that systemic HSL deficient mice developed fatty liver in an age-dependent fashion between 3 and 8 months of age. To further explore the mechanism of fatty liver in HSL deficiency, liver-specific HSL knockout mice were created...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232676/progressive-development-of-aberrant-smooth-muscle-cell-phenotype-in-abdominal-aortic-aneurysm-disease
#19
Kirsten Riches, Emily Clark, Rebecca J Helliwell, Timothy G Angelini, Karen E Hemmings, Marc A Bailey, Katherine I Bridge, D Julian A Scott, Karen E Porter
Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage aneurysm. Human AAA-SMC presented a secretory phenotype and expressed elevated levels of the differentiation marker miR-145 (2...
December 13, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29232563/immunologic-burden-links-periodontitis-to-acute-coronary-syndrome
#20
John M Liljestrand, Susanna Paju, Milla Pietiäinen, Kåre Buhlin, G Rutger Persson, Markku S Nieminen, Juha Sinisalo, Päivi Mäntylä, Pirkko J Pussinen
BACKGROUND AND AIMS: Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal pathogens and their subgingival levels associate with each other, periodontitis, and coronary artery disease. METHODS: The Parogene cohort included 505 Finnish patients (mean age 63 y) who underwent coronary angiography, and clinical and radiographic oral examinations...
December 6, 2017: Atherosclerosis
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