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https://www.readbyqxmd.com/read/29924825/second-harmonic-generation-microscopy-provides-accurate-automated-staging-of-liver-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#1
Pik Eu Chang, George Boon Bee Goh, Wei Qiang Leow, Liang Shen, Kiat Hon Lim, Chee Kiat Tan
BACKGROUND: Assessment of severity of liver fibrosis is essential in the management of non-alcoholic fatty liver disease (NAFLD). Second Harmonic Generation (SHG) microscopy is a novel optical tissue imaging system that provides automated quantification of fibrosis based on unique architectural features of collagen. This study aims to develop and validate a SHG-based index for automated staging of liver fibrosis in patients with NAFLD. METHODS: SHG microscopy was performed on archived liver biopsy specimens from 83 patients with NAFLD...
2018: PloS One
https://www.readbyqxmd.com/read/29924824/effect-of-adiposity-on-tissue-specific-adiponectin-secretion
#2
James Reneau, Matthew Goldblatt, Jon Gould, Tammy Kindel, Andrew Kastenmeier, Rana Higgins, L Rosemary Rengel, Katherine Schoyer, Roland James, Brittaney Obi, Andrea Moosreiner, Kay Nicholson, Daisy Sahoo, Srividya Kidambi
Circulating adiponectin levels are lower in individuals with increased BMI and central adiposity. However, they are paradoxically higher in those with peripheral adiposity. We hypothesized that adiponectin secretion from central and peripheral adipose tissue depots may be associated with adiposity levels and its distribution. A total of 55 subjects (69% women) undergoing elective abdominal surgery (mean age: 53 ± 13 years) were recruited. Health history, anthropometrics, and cardiovascular disease risk factor measurements were obtained...
2018: PloS One
https://www.readbyqxmd.com/read/29924818/limb-bone-histology-records-birth-in-mammals
#3
Carmen Nacarino-Meneses, Meike Köhler
The annual cyclicality of cortical bone growth marks (BGMs) allows reconstruction of some important life history traits, such as longevity, growth rate or age at maturity. Little attention has been paid, however, to non-cyclical BGMs, though some record key life history events such as hatching (egg-laying vertebrates), metamorphosis (amphibians), or weaning (suggested for Microcebus and the hedgehog). Here, we investigate the relationship between non-cyclical BGMs and a stressful biological event in mammals: the moment of birth...
2018: PloS One
https://www.readbyqxmd.com/read/29924755/clinicopathological-study-of-oral-focal-mucinosis-a-retrospective-case-series
#4
A-K-G Gonzaga, D-H-I-P de Oliveira, M-L-D-S Lopes, T-J-S Filho, L-M-G Queiroz, É-J-D da Silveira
BACKGROUND: Oral focal mucinosis (OFM) is a rare soft tissue lesion of unknown etiology that exhibits tumor-like growth. It is considered the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst. This is a retrospective study of oral OFM diagnosed over a period of 42 years at an oral pathology service. MATERIAL AND METHODS: Clinical, histopathological and immunohistochemical data were analyzed. Alcian blue staining and S-100 immunohistochemistry were performed...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924345/recurrent-amplification-of-the-heterochromatin-protein-1-hp1-gene-family-across-dipter
#5
Quentin Helleu, Mia T Levine
The heterochromatic genome compartment mediates strictly conserved cellular processes such as chromosome segregation, telomere integrity, and genome stability. Paradoxically, heterochromatic DNA sequence is wildly unconserved. Recent reports that many hybrid incompatibility genes encode heterochromatin proteins, together with the observation that inter-species hybrids suffer aberrant heterochromatin-dependent processes, suggest that heterochromatic DNA packaging requires species-specific innovations. Testing this model of co-evolution between fast-evolving heterochromatic DNA and its packaging proteins begins with defining the latter...
June 19, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29924332/a-single-swede-midge-diptera-cecidomyiidae-larva-can-render-cauliflower-unmarketable
#6
Chase A Stratton, Elisabeth A Hodgdon, Samuel G Zuckerman, Anthony M Shelton, Yolanda H Chen
Swede midge, Contarinia nasturtii Kieffer (Diptera: Cecidomyiidae), is an invasive pest causing significant damage on Brassica crops in the Northeastern United States and Eastern Canada. Heading brassicas, like cauliflower, appear to be particularly susceptible. Swede midge is difficult to control because larvae feed concealed inside meristematic tissues of the plant. In order to develop damage and marketability thresholds necessary for integrated pest management, it is important to determine how many larvae render plants unmarketable and whether the timing of infestation affects the severity of damage...
May 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29924184/the-influence-of-inspiratory-muscle-training-combined-with-the-pilates-method-on-lung-function-in-elderly-women-a-randomized-controlled-trial
#7
Guilherme Medeiros de Alvarenga, Simone Arando Charkovski, Larissa Kelin Dos Santos, Mayara Alves Barbosa da Silva, Guilherme Oliveira Tomaz, Humberto Remigio Gamba
OBJECTIVE: Aging is progressive, and its effects on the respiratory system include changes in the composition of the connective tissues of the lung that influence thoracic and lung compliance. The Powerbreathe® K5 is a device used for inspiratory muscle training with resistance adapted to the level of the inspiratory muscles to be trained. The Pilates method promotes muscle rebalancing exercises that emphasize the powerhouse. The aim of this study was to evaluate the influence of inspiratory muscle training combined with the Pilates method on lung function in elderly women...
2018: Clinics
https://www.readbyqxmd.com/read/29924008/pacman-flap-for-oncologic-reconstruction-of-soft-tissue-defects-after-tumor-resection-a-retrospective-case-series
#8
Guangxue Li, Lan Mu, Ye Bi, Kai Yang, Yan Liu, Zhe Peng, Yi Zhu, Huiran Zang, Saisai Cao, Peiyang Zhang, Youlei Qian
INTRODUCTION: The Pacman flap is a novel modality for repairing round soft-tissue defects after tumor resection. This modality provides a robust blood supply without microsurgical tissue rearrangement. This article reviews the authors' experience with Pacman flap for reconstruction of round soft-tissue defects. The safety and effectiveness of the Pacman flap are investigated. METHODS: Here, we describe a method for oncologic reconstruction of round soft-tissue defects with a Pacman flap after tumor resection...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923984/clinicopathological-and-prognostic-significance-of-pd-l1-expression-in-sarcoma-a-systematic-review-and-meta-analysis
#9
Chuanxi Zheng, Wei You, Peng Wan, Xiaochun Jiang, Jinquan Chen, Yuchen Zheng, Wei Li, Jifeng Tan, Shiquan Zhang
Programmed cell death-ligands 1 (PD-L1) is a key immune checkpoint protein and a promising therapeutic target for malignancy tumor immunotherapy. The prognostic value of PD-L1 in patients with bone and soft tissue sarcoma remains controversial. Therefore, this meta-analysis is conducted to evaluate the associations of PD-L1 expression with overall survival (OS), progression-free survival (PFS), and clinicopathological characteristics of sarcomaA comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted for relevant studies...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923868/neurofibromatosis-type-2-related-eye-disease-correlated-with-genetic-severity-type
#10
Sally L Painter, Zuzana Sipkova, Beatrice Emmanouil, Dorothy Halliday, Allyson Parry, John S Elston
OBJECTIVE: Neurofibromatosis type 2 (NF2) is an uncommon but well-recognized disorder characterized by multiple schwannomas and meningiomas. Adults typically present with hearing loss and balance disturbance, and children with ocular, dermatological, and neurological signs. Clinical diagnosis is confirmed by neuroimaging and genetic testing. Although ophthalmic features are present in patients with NF2, there are no reports correlating genetic severity subtypes with ophthalmic involvement...
June 19, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29923636/multiphotonic-staging-of-chronic-wounds-and-evaluation-of-sterile-optical-transparent-bacterial-nanocellulose-covering-a-diagnostic-window-into-human-skin
#11
S Springer, M Zieger, U C Hipler, J Lademann, V Albrecht, R Bueckle, C Meß, M Kaatz, V Huck
BACKGROUND: Diagnostics of healing, infection, and inflammation in chronic wounds in comparison with physiological wound healing in acute wounds may help for therapy decisions toward individualized therapy management. With emerging new optical techniques the coupling of optical diagnostic devices with tissue provides a great challenge. Traditional coupling with cover slips is used since the early days of microscopy. In modern health care, hygienic covering of surfaces is necessary to avoid infections and cross-contaminations...
June 20, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29923341/organochlorine-pesticide-residues-in-human-breast-tissue-and-their-relationships-with-clinical-and-pathological-characteristics-of-breast-cancer
#12
Rachel E Ellsworth, Paul J Kostyniak, Lai-Har Chi, Craig D Shriver, Nicholas S Costantino, Darrell L Ellsworth
Agricultural pesticides are abundant environmental contaminants worldwide, prompting interest in studying their possible detrimental health effects. We examined organochlorine residues by quadrant (n = 245) in breast adipose tissues from 51 women with various stages of breast health to determine patterns of bioaccumulation within the breast and to assess relationships with patient clinical characteristics. Three organochlorine residues-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), hexachlorobenzene (HCB), and mirex-assayed by high resolution gas chromatography were abundant in breast tissue...
June 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29923191/effects-of-endurance-exercise-training-on-inflammatory-circulating-progenitor-cell-content-in-lean-and-obese-adults
#13
Grace M Niemiro, Jacob M Allen, Lucy J Mailing, Naiman A Khan, Hannah D Holscher, Jeffrey A Woods, Michael De Lisio
KEY POINTS: Chronic inflammation underlies many of the health decrements associated with obesity. Circulating progenitor cells can sense and respond to inflammatory stimuli, increasing the local inflammatory response within tissues. Here we show that 6 weeks of endurance exercise training significantly decreases inflammatory circulating progenitor cells in obese adults. These findings provide novel cellular mechanisms for the beneficial effects of exercise in obese adults. ABSTRACT: Circulating progenitor cells (CPCs) and subpopulations are normally found in the bone marrow, but can migrate to peripheral tissues to participate in local inflammation and/or remodelling...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29923043/current-treatment-of-endolymphatic-sac-tumor-of-the-temporal-bone
#14
REVIEW
William M Mendenhall, Carlos Suárez, Alena Skálová, Primož Strojan, Asterios Triantafyllou, Kenneth O Devaney, Michelle D Williams, Alessandra Rinaldo, Alfio Ferlito
An endolymphatic sac tumor (ELST) is a rare, indolent but locally aggressive tumor arising in the posterior petrous ridge. Patients present with sensorineural hearing loss and tinnitus. As the tumor progresses, patients may experience vertigo, ataxia, facial nerve paresis, pain and otorrhea. Most patients present in their 4th or 5th decade with a wide age range. Patients with von Hippel-Lindau disease have an increased likelihood of developing ELST. Histologically, ELST is a low-grade adenocarcinoma. As it progresses, it destroys bone and extends into adjacent tissues...
June 19, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29922963/endocrine-treatment-of-aging-transgender-people
#15
REVIEW
Louis J Gooren, Guy T'Sjoen
High quality empirical data assessing morbidity and mortality and cancer incidence among transgender people are almost non-existent. Sex hormone treatment of conditions in older non-transgender people might as yet be taken as the best available analogy to hormone administration to aging transgender persons. Testosterone administration to transgender men carries little risk with regard to cardiovascular disease and cancer. A dose adaptation may be needed in men with a high hematocrit or cardiac insufficiency...
June 19, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29922939/a-decrease-in-vitamin-d-levels-is-associated-with-methotrexate-induced-oral-mucositis-in-children-with-acute-lymphoblastic-leukemia
#16
N Oosterom, N F Dirks, S G Heil, R de Jonge, W J E Tissing, R Pieters, M M van den Heuvel-Eibrink, A C Heijboer, S M F Pluijm
PURPOSE: Children with acute lymphoblastic leukemia (ALL) are at increased risk of vitamin D deficiency, which might make them more susceptible to developing adverse events. Previous studies showed that low vitamin D levels were associated with an increased inflammatory mucosal state and impaired mucosal tissue barriers. We examined the prevalence of vitamin D deficiency and studied the association between vitamin D levels and methotrexate (MTX)-induced oral mucositis in pediatric ALL...
June 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29922898/measurements-in-cervical-vertebrae-ct-of-pediatric-cases-normal-values
#17
Yeliz Akturk, Serra Ozbal Gunes
PURPOSE: This study aims to determine the normal limits of atlanto-dental interval (ADI), basion-dens interval (BDI), basion-cartilaginous dens interval (BCDI), and prevertebral soft tissue thickness (PVSTT) according to age groups for normal pediatric cases. MATERIALS AND METHODS: CT images of 256 pediatric patients aged between 1 and 15 years were retrospectively evaluated. ADI, BDI, BCDI and PVSTT measurements were performed. RESULTS: Upper normal limit (UNL) values for ADI were 2...
June 19, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29922706/soy-protein-improves-tibial-whole-bone-and-tissue-level-biomechanical-properties-in-ovariectomized-and-ovary-intact-low-fit-female-rats
#18
Pamela S Hinton, Laura C Ortinau, Rebecca K Dirkes, Emily L Shaw, Matthew W Richard, Terese Z Zidon, Steven L Britton, Lauren G Koch, Victoria J Vieira-Potter
Background: Osteoporosis and related fractures, decreased physical activity, and metabolic dysfunction are serious health concerns for postmenopausal women. Soy protein might counter the negative effects of menopause on bone and metabolic health due to the additive or synergistic effects of its bioactive components. Objective: To evaluate the effects of ovariectomy (OVX) and a soy-protein diet (SOY) on bone outcomes in female, low-capacity running (LCR) rats selectively bred for low aerobic fitness as a model of menopause...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29922541/chest-wall-reconstruction-with-porcine-acellular-dermal-matrix-strattice-and-autologous-tissue-transfer-for-high-risk-patients-with-chest-wall-tumors
#19
Haitham H Khalil, Maninder Kalkat, Marco N Malahias, Saif Rhobaye, Tarek Ashour, Madava G Djearaman, Babu Naidu
Background: Tenets of chest wall reconstruction for malignancy are well known; however, the insertion of synthetic prosthetic material to achieve rigid and nonrigid skeletal reconstruction could be associated with more complications including infection and extrusion especially in high risk patients. This includes fungating, infected tumors, previous radiotherapy, scars, smoking, diabetes, and morbid obesity. Bioprosthesis Acelluar Dermal Matrix Strattice would be a substitute to resist infection and provide stable coverage...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29922536/respiratory-epithelial-adenomatoid-hamartoma-an-important-differential-of-sinonasal-masses
#20
Darren Rom, Migie Lee, Edward Chandraratnam, Ronald Chin, Niranjan Sritharan
Background Respiratory epithelial adenomatoid hamartomas (REAH) are rare, glandular proliferations of the aerodigestive tract lined by ciliated respiratory epithelium. We report nine cases of REAH and devised a histopathological guide to differentiate these lesions from its main differentials. Methods Patients with biopsy-proven REAH were included in the series. Lesions were removed endoscopically and sent for histopathological analysis. The macroscopic and microscopic features were reviewed. Results Nine patients (age 59 ± 15...
April 17, 2018: Curēus
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