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https://www.readbyqxmd.com/read/29475036/adamts-6-is-a-predictor-of-poor-prognosis-in-patients-with-esophageal-squamous-cell-carcinoma
#1
Lan Liu, Zhaoting Yang, Weidong Ni, Yanhua Xuan
BACKGROUND: A disintegrin and metalloprotease with thrombospondin motif (ADAMTS) enzymes play important roles in cell functions including adhesion, invasion, migration, and proliferation. ADAMTS-6 is a member of the ADAMTS family; reports of its relationship with esophageal squamous cell carcinoma (ESCC) progression are rare. It is unclear whether ADAMTS-6 could be an independent ESCC biomarker. METHODS: ADAMTS-6 expression was detected by immunohistochemistry (IHC) in 171 paraffin-embedded ESCC specimens; relationships with patients' clinicopathological features and Twist-1 expression were analyzed by the Pearson Chi-square method, respectively...
February 20, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29474873/expression-of-nucleotide-excision-repair-in-alzheimer-s-disease-is-higher-in-brain-tissue-than-in-blood
#2
Helge Leander B Jensen, Meryl S Lillenes, Alberto Rabano, Clara-Cecilie Günther, Tahira Riaz, Shewit T Kalayou, Ingun D Ulstein, Thomas Bøhmer, Tone Tønjum
Age-related changes are increased in patients with Alzheimer's disease (AD), including oxidative stress and DNA damage. We propose that genotoxic stress and DNA repair responses influence neurodegeneration in the pathogenesis of AD. Here, we focus on nucleotide excision repair (NER). Real-time qPCR and mass spectrometry were employed to determine the expression levels of selected NER components. The mRNA levels of the genes encoding the NER proteins RAD23B, RPA1, ERCC1, PCNA and LIG3 as well as the NER-interacting base excision repair protein MPG in blood and brain tissue from four brain regions in patients with AD or mild cognitive impairment and healthy controls (HC), were assessed...
February 20, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29474509/blepharoplasty-anatomy-planning-techniques-and-safety
#3
Mohammed Alghoul
Blepharoplasty is one of the most commonly performed cosmetic surgical procedures. To date it remains the most powerful method of periorbital rejuvenation when compared to other non-surgical modalities, especially in the aging face. Despite that, the procedure has its shortcomings that include a steep learning curve, prolonged recovery and potential for appearance and life-changing complications. Attaining successful outcomes rely on solid understanding of facial topography, patient and technique selection, and, when appropriate, following a conservative approach...
February 21, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29474484/transgenerational-effects-of-prenatal-restricted-diet-on-gene-expression-and-histone-modifications-in-the-rat
#4
Joanna Nowacka-Woszuk, Izabela Szczerbal, Anna M Malinowska, Agata Chmurzynska
Dietary triggers acting on a developing fetus can affect the functioning of the body in later life; this can be observed on various levels, including epigenetic modifications and gene expression. Early-life programmed changes may be transmitted to successive generations. In this study, the impact of prenatal restricted diet was studied in four generations of rats. We hypothesized that this diet can induce changes in the expression of major genes involved in two epigenetic mechanisms: DNA methylation and histone modifications...
2018: PloS One
https://www.readbyqxmd.com/read/29474424/the-longitudinal-association-between-changes-in-lung-function-and-changes-in-abdominal-visceral-obesity-in-korean-non-smokers
#5
Eun Kyung Choe, Hae Yeon Kang, Young Lee, Seung Ho Choi, Hee Joung Kim, Joo Sung Kim
Obesity, particularly abdominal obesity, might be related to decreased lung function. We aimed to investigate whether obesity indices are associated with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) in asymptomatic non-smokers through a longitudinal cohort study. The clinical records of 1,145 subjects (428 males, mean age 52.3 years) who underwent a comprehensive health evaluation, including spirometry and abdominal fat computed tomography, at least twice between 2007 and 2014 were retrospectively reviewed and analysed...
2018: PloS One
https://www.readbyqxmd.com/read/29474278/operating-room-efficiency-examining-the-impact-of-personnel-handoffs
#6
Julia Geynisman-Tan, Oluwateniola Brown, Margaret Mueller, Katarzyna Bochenska, Sarah Collins, Christina Lewicky-Gaupp, Kimberly Kenton
OBJECTIVES: This study aimed to determine if personnel handoffs or number of learners in the operating room (OR) are associated with longer OR times in women having pelvic organ prolapse surgery. METHODS: A retrospective review of women undergoing prolapse surgery in 2016 was conducted. Demographics; procedure; OR, anesthetic, and surgical time; number of handoffs between anesthesia members, circulators, and surgical technologies; and number of learners were abstracted...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29473959/reconstruction-using-a-constrained-type-hip-tumor-prosthesis-after-resection-of-malignant-periacetabular-tumors-a-study-by-the-japanese-musculoskeletal-oncology-group-jmog
#7
Koichi Ogura, Michiro Susa, Hideo Morioka, Akihiko Matsumine, Takeshi Ishii, Kenichiro Hamada, Takafumi Ueda, Akira Kawai
BACKGROUND: We conducted a nationwide survey of prosthetic reconstruction using a constrained-type hip tumor prosthesis (C-THA) following resection of periacetabular tumors. METHODS: Eighty patients with periacetabular tumors underwent wide resection and prosthetic reconstruction using C-THA at JMOG-affiliated institutions (39 males and 41 females; mean age, 46.7 years; mean follow-up period, 65 months). Primary bone or soft tissue sarcoma accounted for 75% of the cases...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473815/incidence-of-symptomatic-tethered-spinal-cord-in-pediatric-patients-presenting-with-neurofibromatosis-types-1-and-2
#8
Carolyn S Quinsey, Katie Krause, Lissa C Baird, Christina M Sayama, Nathan R Selden
OBJECTIVE The relationship between a tethered cord (TC) and neurofibromatosis type 1 (NF1) and NF2 is not known. The purpose of this study was to define the incidence of TC in pediatric neurosurgical patients who present with NF. METHODS The authors performed a single-institution (tertiary care pediatric hospital) 10-year retrospective analysis of patients who were diagnosed with or who underwent surgery for a TC and/or NF. Clinical and radiological characteristics were analyzed, as was histopathology. RESULTS A total of 424 patients underwent surgery for a TC during the study period, and 67 patients with NF were seen in the pediatric neurosurgery clinic...
February 23, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29473463/markers-of-neutrophil-extracellular-traps-are-associated-with-adverse-clinical-outcome-in-stable-coronary-artery-disease
#9
Miriam Sjåstad Langseth, Trine Baur Opstad, Vibeke Bratseth, Svein Solheim, Harald Arnesen, Alf Åge Pettersen, Ingebjørg Seljeflot, Ragnhild Helseth
Background Neutrophil extracellular traps, comprising chromatin and granule proteins, have been implicated in atherothrombosis. Design and methods We investigated whether the circulating neutrophil extracellular traps markers, double-stranded DNA and myeloperoxidase-DNA were associated with clinical outcome and hypercoagulability in patients with stable coronary artery disease. Patients with angiographically verified stable coronary artery disease ( n = 1001) were included. Follow-up was 2 years, recording 106 clinical endpoints (unstable angina, non-haemorrhagic stroke, myocardial infarction or death)...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29473323/adult-spinal-opioid-receptor-%C3%A2%C2%B51-expression-after-incision-is-altered-by-early-life-repetitive-tactile-and-noxious-procedures-in-rats
#10
Nynke J van den Hoogen, Roel Ri van Reij, Jacob Patijn, Dick Tibboel, Elbert Aj Joosten
Clinical and experimental data suggests that noxious stimulation at critical stages of development results in long-term changes on nociceptive processing in later life. Here, we use an established, well-documented rat model of repetitive noxious procedures closely mimicking the clinical situation in the NICU. In order to understand molecular changes underlying the long-term consequences of repetitive stimulation of the developing nociceptive system the present study aims to analyse the presence of the µ-opioid-receptor-1 (OPRM1)...
February 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29473197/heritability-of-the-airway-structure-and-head-posture-using-twin-study
#11
Jeong-Hyun Kang, Joohon Sung, Yun-Mi Song, Young-Ho Kim
BACKGROUND: Inherited traits of obstructive sleep apnea (OSA) may have link to the heritability of the airway anatomy. OBJECTIVES: The aim of present study was to investigate heritability of the airway anatomy by comparing skeletal and soft tissue features of Korean monozygotic (MZ) and dizygotic twins (DZ). METHODS: In total, 72 participants (mean age, 41.5 ± 5.9 years; 40 males, 32 females) including 48 MZ (24 pairs) and 24 DZ (12 pairs) with same sex were participated...
February 23, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29473159/developmental-and-degenerative-cardiac-defects-in-the-taiwanese-mouse-model-of-severe-spinal-muscular-atrophy
#12
Gillian K Maxwell, Eva Szunyogova, Hannah K Shorrock, Thomas H Gillingwater, Simon H Parson
Spinal muscular atrophy (SMA), an autosomal recessive disease caused by a decrease in levels of the survival motor neuron (SMN) protein, is the most common genetic cause of infant mortality. Although neuromuscular pathology is the most severe feature of SMA, other organs and tissues, including the heart, are also known to be affected in both patients and animal models. Here, we provide new insights into changes occurring in the heart, predominantly at pre- and early symptomatic ages, in the Taiwanese mouse model of severe SMA...
February 22, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29473153/serum-insulin-like-growth-factor-i-and-insulin-like-growth-factor-binding-protein-3-in-relation-to-terminal-duct-lobular-unit-involution-of-the-normal-breast-in-caucasian-and-african-american-women-the-susan-g-komen-tissue-bank
#13
Hannah Oh, Ruth M Pfeiffer, Roni T Falk, Hisani N Horne, Jackie Xiang, Michael Pollak, Louise A Brinton, Anna Maria V Storniolo, Mark E Sherman, Gretchen L Gierach, Jonine D Figueroa
Lesser degrees of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini/TDLU, are associated with elevated breast cancer risk. In rodent models, the insulin-like growth factor (IGF) system regulates involution of the mammary gland. We examined associations of circulating IGF measures with TDLU involution in normal breast tissues among women without precancerous lesions. Among 715 Caucasian and 283 African American (AA) women who donated normal breast tissue samples to the Komen Tissue Bank between 2009 to 2012 (75% premenopausal), serum concentrations of IGF-I and binding protein (IGFBP)-3 were quantified using enzyme-linked immunosorbent assay...
February 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29473115/the-effects-of-exercise-training-associated-with-low-level-laser-therapy-on-biomarkers-of-adipose-tissue-transdifferentiation-in-obese-women
#14
Raquel Munhoz da Silveira Campos, Ana Raimunda Dâmaso, Deborah Cristina Landi Masquio, Fernanda Oliveira Duarte, Marcela Sene-Fiorese, Antonio Eduardo Aquino, Filippo Aragão Savioli, Pamela Cristina Lopes Quintiliano, Ana Claudia Pelissari Kravchychyn, Liliane Isabel Guimarães, Lian Tock, Lila Missae Oyama, Valter Tadeu Boldarine, Vanderlei Salvador Bagnato, Nivaldo Antonio Parizotto
Investigations suggest the benefits of low-level laser therapy (LLLT) to improve noninvasive body contouring treatments, inflammation, insulin resistance and to reduce body fat. However, the mechanism for such potential effects in association with exercise training (ET) and possible implications in browning adiposity processes remains unclear. Forty-nine obese women were involved, aged between 20 and 40 years with a body mass index (BMI) of 30-40 kg/m2 . The volunteers were divided into Phototherapy (808 nm) and SHAM groups...
February 23, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29472980/pediatric-farm-injuries-morbidity-and-mortality
#15
Clint Rathje, Ashley Venegas, Stephen D Helmer, Rachel M Drake, Jeanette G Ward, James M Haan
Background: Agriculture is an industry where family members often live and work on the same premises. This study evaluated injury patterns and outcomes in children from farm-related accidents. Methods: A 10-year retrospective review of farm-accident related injuries was conducted of patients 17 years and younger. Data collected included demographics, injury mechanism, accident details, injury severity and patterns, treatments required, hospitalization details, and discharge disposition...
November 2017: Kansas Journal of Medicine
https://www.readbyqxmd.com/read/29472744/properties-of-body-composition-of-female-representatives-of-the-polish-national-fencing-team-the-sabre-event
#16
Władysław Jagiełło, Jagiełło Marina, Kalina Roman Maciej, Barczyński Bartłomiej Jan, Litwiniuk Artur, Klimczak Jarosław
Fencing is a combat sport whose form of direct confrontation involves hitting the opponent with a weapon. The purpose of the study was to determine the properties of body composition of female representatives of the Polish national fencing team. The study involved 11 female athletes of the Polish national fencing team. Their age was 16-22 years (19±2.32), body weight 52-78 kg (59.7±7.4), body height 158-183 cm (167.46±6.10) and the training experience 7.64±3.47 years. The reference group consisted of 153 students of Warsaw University of Technology (Poland)...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29472706/atm-reactivation-reverses-ataxia-telangiectasia-phenotypes-in-vivo
#17
Sara Di Siena, Federica Campolo, Roberto Gimmelli, Chiara Di Pietro, Daniela Marazziti, Susanna Dolci, Andrea Lenzi, Andre Nussenzweig, Manuela Pellegrini
Hereditary deficiencies in DNA damage signaling are invariably associated with cancer predisposition, immunodeficiency, radiation sensitivity, gonadal abnormalities, premature aging, and tissue degeneration. ATM kinase has been established as a central player in DNA double-strand break repair and its deficiency causes ataxia telangiectasia, a rare, multi-system disease with no cure. So ATM represents a highly attractive target for the development of novel types of gene therapy or transplantation strategies...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29472133/vaccine-safety-testing-using-magnetic-resonance-imaging-in-suckling-pigs
#18
Maren Bernau, Bernd Große Liesner, Sebastian Schwanitz, Ann-Sophie Kraus, Almuth Falkenau, Miriam Leipig-Rudolph, Walter Hermanns, Armin Manfred Scholz
Safety testing is one major part of the licensing procedure for veterinary vaccines and demands a large number of animals. Magnetic resonance imaging (MRI) was tested as an alternative, which may lead to a reduction in numbers of animals required for safety testing, and, correspondingly to a detailed description of the three-dimensional extent of the local tissue reaction repetitively in live pigs. In previous pig studies the following questions arose:To answer these questions the following study was performed by comparing two vaccine groups of suckling piglets (8 animals per group; A and B) with two control groups (4 animals per group; C and D)...
February 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29472042/identification-of-predictors-for-wound-complications-following-preoperative-or-postoperative-radiotherapy-in-extremity-soft-tissue-sarcoma
#19
Marc G Stevenson, Jan F Ubbels, Jelena Slump, Marijn A Huijing, Esther Bastiaannet, Elisabeth Pras, Harald J Hoekstra, Lukas B Been
INTRODUCTION: In extremity soft tissue sarcoma (ESTS), external beam radiotherapy (EBRT) has been used in addition to limb-sparing surgery (LSS). This study aims to identify predictors for major wound complication (MWC) development following EBRT and LSS in ESTS. METHODS: This retrospective study includes ESTS patients treated with EBRT and LSS between 2005 and 2017. Two groups were formed; Group I included preoperatively irradiated patients, whereas Group II included patients who underwent postoperative EBRT...
February 9, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29471816/idiopathic-pulmonary-fibrosis-pathogenesis-and-management
#20
REVIEW
Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone, Luca Richeldi
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor prognosis. This review will present the substantial advances achieved in the understanding of IPF pathogenesis and in the therapeutic options that can be offered to patients, and will address the issues regarding diagnosis and management that are still open. MAIN BODY: Over the last two decades much has been clarified about the pathogenic pathways underlying the development and progression of the lung scarring in IPF...
February 22, 2018: Respiratory Research
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