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https://www.readbyqxmd.com/read/29054118/efficacy-of-laryngectomy-alone-for-treatment-of-locally-advanced-laryngeal-cancer-a-stage-and-subsite-specific-survival-analysis
#1
Brian P Cervenka, Shyam Rao, D Gregory Farwell, Arnaud F Bewley
OBJECTIVE: Total laryngectomy is a well-established treatment for locally advanced laryngeal cancer. Evidence for the benefit of post-operative radiotherapy after laryngectomy in patients with locally advanced primaries and N0 or N1 nodal disease is limited. This study aims to determine whether total laryngectomy alone is adequate therapy for certain patient subgroups with locally advanced laryngeal cancer. DESIGN: We performed a retrospective survival analysis of patients in the surveillance epidemiology and end results (SEER) database with locally advanced laryngeal cancer between 2004-2012...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054111/dipeptidyl-peptidase-4-inhibitors-attenuates-the-decline-of-skeletal-muscle-mass-in-patients-with-type-2-diabetes
#2
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
BACKGROUND: Activation of dipeptidyl peptidase 4 (DPP4) has been reported to be associated with impairment of insulin signaling in skeletal muscle mass, presumably leading to loss of muscle function. This study was aimed to investigate whether the use of DPP4 inhibitors (DPP4i) could attenuate the progressive loss of muscle mass in patients with type 2 diabetes. METHODS: A total 105 patients with type 2 diabetes (mean age 62 ± 12 years; 39% female) were studied in this retrospective observational study...
October 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29054110/mortality-burden-from-seasonal-influenza-and-2009-h1n1-pandemic-influenza-in-beijing-china-2007-2013
#3
REVIEW
Shuangsheng Wu, Zaihua Wei, Carolyn M Greene, Peng Yang, Jianting Su, Ying Song, A Danielle Iuliano, Quanyi Wang
BACKGROUND: Data about influenza mortality burden in northern China are limited. This study estimated mortality burden in Beijing associated with seasonal influenza from 2007-2013 and the 2009 H1N1 pandemic. METHODS: We estimated influenza-associated excess mortality by fitting a negative binomial model using weekly mortality data as the outcome of interest with the percent of influenza positive samples by type/subtype as predictor variables. RESULTS: From 2007 to 2013, an average of 2,375 (CI 1,002-8,688) deaths was attributed to influenza per season, accounting for 3% of all deaths...
October 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29054106/age-of-diagnosis-incidence-and-prevalence-of-recurrent-respiratory-papillomatosis-a-south-african-perspective
#4
R Y Seedat, R Schall
OBJECTIVES: To determine the distribution of the age of onset of recurrent respiratory papillomatosis (RRP) and to determine the incidence and prevalence of RRP in both adults and children in the Free State province of South Africa in order to provide data from a population in sub-Saharan African. DESIGN: Retrospective record review. PARTICIPANTS: All patients with recurrent respiratory papillomatosis in the Free State province of South Africa between 2011 and 2015...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054073/discourse-production-of-mandarin-speaking-children-with-high-functioning-autism-the-effect-of-mental-and-action-verbs-semantic-pragmatic-features
#5
Yiqi Song, Zhongheng Jia, Shunhua Liu, Dandan Liang
The present study investigated the syntactic and pragmatic performance of children with high-functioning autism (HFA) during a discourse production task with mental verbs. Children with HFA and typically developing (TD) children were matched by chronological age, verbal IQ (VIQ) and full-scale IQ (FIQ). We found that children with HFA tended to select a nominal object given a mental verb with either a nominal or clausal object. They committed few syntactic errors but generated syntactic stereotypes with mental verbs...
October 16, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29054051/the-incidence-and-risk-factors-of-epilepsy-in-children-born-preterm-a-nationwide-register-study
#6
Mikko Hirvonen, Riitta Ojala, Päivi Korhonen, Paula Haataja, Kai Eriksson, Mika Gissler, Tiina Luukkaala, Outi Tammela
OBJECTIVES: The aim was to compare the incidence of epilepsy between very preterm (VP) (<32(+0) weeks), moderately preterm (MP) (32(+0)-33(+6) weeks), late preterm (LP) (34(+0)-36(+6) weeks) and term infants (≥37 weeks) and to establish and compare risk factors of epilepsy in these groups. METHODS: The national register study included all live born infants in Finland in 1991-2008. Excluding infants with missing gestational age, a total of 1,033,349 infants were included in the analysis and they were analyzed in four subgroups (VP, MP, LP and term) and three time periods (1991-1995, 1996-2001 and 2002-2008)...
October 14, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29054044/metacognitive-deficits-in-categorization-tasks-in-a-population-with-impaired-inner-speech
#7
Peter Langland-Hassan, Christopher Gauker, Michael J Richardson, Aimee Dietz, Frank R Faries
This study examines the relation of language use to a person's ability to perform categorization tasks and to assess their own abilities in those categorization tasks. A silent rhyming task was used to confirm that a group of people with post-stroke aphasia (PWA) had corresponding covert language production (or "inner speech") impairments. The performance of the PWA was then compared to that of age- and education-matched healthy controls on three kinds of categorization tasks and on metacognitive self-assessments of their performance on those tasks...
October 17, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29054023/charting-the-territory-describing-the-functional-abilities-of-children-with-progressive-neurological-conditions
#8
Sandy K Tatla, Liisa Holsti, Gail Stephanie Andrews, Leanne Feichtinger, Rose Steele, Harold Siden
AIMS: Little is known about the functional abilities of children with progressive genetic, metabolic, or neurological conditions (PNCs). In this study, children with PNCs were followed over a 2-year period to assess their functional abilities over time. Specific aims were to: 1) describe the changes in functional skills and the effects of age for children with PNCs, 2) assess changes in these children's need for caregiver assistance over time, and 3) examine relationships between these children's functional skills and need for caregiver assistance...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29053994/dietary-resveratrol-confers-apoptotic-resistance-to-oxidative-stress-in-myoblasts
#9
Satoshi Haramizu, Shinichi Asano, David C Butler, David A Stanton, Ameena Hajira, Junaith S Mohamed, Stephen E Alway
High levels of reactive oxygen species (ROS) contribute to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not known if resveratrol would protect muscle stem cells during repair or regeneration when oxidative stress is high. To test the protective role of resveratrol on muscle stem cells directly, we treated the C2C12 mouse myoblast cell line with moderate (100 μM) or very high (1 mM) levels of H2O2 in the presence or absence of resveratrol...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053991/molecular-mechanisms-of-development-of-the-human-fetal-female-reproductive-tract
#10
Gerald R Cunha, Takeshi Kurita, Mei Cao, Joel Shen, Stanley Robboy, Laurence Baskin
Human female reproductive tract development rests mostly upon hematoxilyn and eosin stained sections despite recent advances on molecular mechanisms in mouse studies. We report application of immunohistochemical methods to explore the ontogeny of epithelial and mesenchymal differentiation markers (keratins, homobox proteins, steroid receptors), transcription factors and signaling molecules (TP63 and RUNX1) during human female reproductive tract development. Keratins 6, 7, 8, 10, 14 and 19 (KRT6, KRT7, KRT8, KRT10, KRT14, KRT19) were expressed in a temporally and spatially dynamic fashion...
July 29, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29053989/psychometric-properties-of-the-child-anxiety-life-interference-scale-preschool-version
#11
Tamsyn J Gilbertson, Amy J Morgan, Ronald M Rapee, Heidi J Lyneham, Jordana K Bayer
Despite growing recognition of childhood anxiety as a common and often debilitating clinical concern, we have limited knowledge of the particular ways in which anxiety interferes with daily life for young children who have not yet entered formal schooling. The present study evaluated the psychometric properties of the Child Anxiety Life Interference Scale - Preschool Version (CALIS-PV). The CALIS-PV is a brief (18 item) parent-report measure of the impacts of a young child's anxiety on their own life and that of her or his parent...
October 13, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29053986/metacognitions-in-smoking-evidence-from-a-cross-cultural-validation-of-the-metacognitions-about-smoking-questionnaire-in-a-turkish-sample
#12
Leyla Alma, Marcantonio M Spada, Bruce A Fernie, Adviye Esin Yilmaz-Samanci, Gabriele Caselli, Ana V Nikčević
Metacognitions about the positive and negative effects of smoking have been associated with cigarette use and nicotine dependence. The aim of the present study was to validate the Turkish version of the Metacognitions about Smoking Questionnaire (MSQ; Nikčević et al., 2015). The sample consisted of 859 self-declared smokers (452 female) aged between 18 and 68 years (mean = 28.3; SD = 7.9). Once the English to Turkish translation of the MDQ was completed, confirmatory factor analyses were conducted based on the four-factor structure of the original measure...
October 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29053982/a-longitudinal-test-of-the-predictions-of-the-interpersonal-psychological-theory-of-suicidal-behaviour-for-passive-and-active-suicidal-ideation-in-a-large-community-based-cohort
#13
Philip J Batterham, Jennie Walker, Liana S Leach, Jennifer Ma, Alison L Calear, Helen Christensen
BACKGROUND: The Interpersonal-Psychological Theory of Suicide (IPTS) aims to elucidate the key antecedents of suicide deaths. Limited research has tested the IPTS in a community setting, and very little longitudinal research has been conducted. The current study longitudinally tested the predictions of the IPTS for suicidal ideation in a large population-based sample. METHODS: The PATH through Life study assesses three age cohorts (20's, 40's, 60's) every four years...
October 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053980/incident-mental-disorders-in-the-aftermath-of-traumatic-events-a-prospective-longitudinal-community-study
#14
Eva Asselmann, Hans-Ulrich Wittchen, Roselind Lieb, Axel Perkonigg, Katja Beesdo-Baum
BACKGROUND: Few strictly prospective-longitudinal community studies examined the role of traumatic events for risk of developing a broad range of incident mental disorders over several years. METHOD: A representative community sample of adolescents and young adults (n = 2797, baseline age 14-24) was prospectively examined in up to three assessment waves over up to 10 years. Traumatic events and DSM-IV mental disorders were assessed at each wave using the DIA-X/M-CIDI...
October 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053975/depression-among-female-heads-of-household-in-rural-mozambique-a-cross-sectional-population-based-survey
#15
Carolyn M Audet, Milton L Wainberg, Maria A Oquendo, Qiongru Yu, Meridith Blevins Peratikos, Cristiane S Duarte, Samuel Martinho, Ann F Green, Lazaro González-Calvo, Troy D Moon
BACKGROUND: An estimated 350 million people live with depression worldwide. In Mozambique, there are no national data quantifying the burden of mental illnesses. With the sixth highest suicide rate in the world, there is strong evidence of an unmet mental health need. We conducted a survey to measure the prevalence of depression among female heads of household and assess individual, social, and cultural risk factors associated with a positive depression screening. METHODS: This survey was conducted across 14 rural districts in central Mozambique in 2014...
October 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053973/duration-of-moderate-to-vigorous-daily-activity-is-negatively-associated-with-slow-walking-speed-independently-from-step-counts-in-elderly-women-aged-75-years-or-over-a-cross-sectional-study
#16
Takuji Adachi, Yuji Kono, Kotaro Iwatsu, Yuko Shimizu, Sumio Yamada
OBJECTIVES: This study aimed 1) to examine whether objectively measured duration of moderate to vigorous physical activity (MVPA) was associated with slow walking speed, independent from step counts, in elderly women aged 75 or over (old-old) and 2) to determine a possible cut-off value for duration of MVPA related to slow walking speed. METHODS: Participants were 350 community-dwelling old-old women. Slow walking speed was defined as usual walking speed <1.0m/s...
October 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29053942/do-elite-breath-hold-divers-suffer-from-mild-short-term-memory-impairments
#17
François Billaut, Patrice Gueit, Sylvane Faure, Guillaume Costalat, Frédéric Lemaitre
Repeated apneas are associated with severe hypoxemia that may ultimately lead to loss of consciousness in some breath-hold divers. Despite increasing number of practitioners, the relationship between apnea-induced hypoxia and neurocognitive functions is still poorly understood in the sport of free diving. To shed light onto this phenomenon, we examined the impact of long-term breath-hold diving training on attentional processing, short-term memory, and long-term mnesic and executive functions. Thirty-six men matched for age, height and weight were separated into three groups [12 elite breath-hold divers (EBHD, mean static apnea best time 371 sec, 105 months mean apnea experience); 12 novice breath-hold divers (NBHD, mean best time 243 sec, 8...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053937/studies-with-herpes-zoster-vaccines-in-immune-compromised-patients
#18
Myron J Levin, Eddy Bresnitz, Zoran Popmihajlov, Adriana Weinberg, Kai-Li Liaw, English Willis, Jeffrey R Curtis
INTRODUCTION: The active component of the herpes zoster vaccine (ZVL), recommended for people ≥50 years of age, is a live attenuated varicella-zoster virus. ZVL is contraindicated for immune compromised individuals, with limited regard to the degree of immunosuppression. Areas covered: This review evaluates phase I and II, and observational studies for ZVL and published reports of the off-label use of ZVL, for conditions and therapies for which investigators considered the risk-benefit for using ZVL to be favorable...
October 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29053933/chronic-administration-of-ellagic-acid-improved-the-cognition-in-male-middle-aged-overweight
#19
Ying Liu, Shuyi Yu, Fen Wang, Haitao Yu, Xueli Li, Wanru Dong, Ruichao Lin, Qingshan Liu
This study aims to investigate whether ellagic acid has beneficial effects on cognitive deficits in middle-aged overweight individuals and the possible mechanism. A total of 150 middle-aged male participants, including 76 normal weight and 74 overweight, aged between 45 to 55 years were recruited for this study. Both normal weight and overweight participants were administered either 50 mg ellagic acid or placebo cellulose daily for 12 weeks. Blood lipids, peripheral brain-derived neurotrophic factor (BDNF) and saliva cortisol were assessed on the last day of the procedure to investigate the effects induced by ellagic acid...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053913/morphological-changes-of-the-internal-carotid-artery-prevalence-and-characteristics-a-clinic-and-ultrasonographic-study-in-a-series-of-19-804-patients-over-25-years-old
#20
Hugo F G Martins, Alexandra Mayer, Paulo Batista, Fátima Soares, Vanessa Almeida, Ana Júlia Pedro, Victor Oliveira
BACKGROUND: Morphological changes of the internal carotid arteries (McICA) are frequently found during cervical ultrasound studies. However, McICA's etiology remains controversial. During this study, the prevalence and demographic characteristics of McICA such as kinking, coiling or looping, identified by Doppler ultrasound, were analysed and its relationship with vascular risk factors and stroke was assessed. METHODS: A retrospective study was performed by analysing 19,804 patients between Jan 2000 and Jun 2012 who were submitted to cervical ultrasonographic study...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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