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Ahmed Ba-Ssalamah, Nina Bastati, Andreas Wibmer, Romana Fragner, Jacqueline C Hodge, Michael Trauner, Christian J Herold, Mustafa R Bashir, Bernard E Van Beers
: MRI has emerged as the most comprehensive noninvasive diagnostic tool for focal liver lesions and diffuse hepatobiliary disorders. The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, particularly in the functional imaging of chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD). GA-enhanced MRI (GA-MRI) may help to distinguish between the two subgroups of NAFLD, simple steatosis and nonalcoholic steatohepatitis...
November 8, 2016: Journal of Magnetic Resonance Imaging: JMRI
Michele Di Martino, Lucia Pacifico, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Claudio Chiesa, Carlo Catalano
AIM: To establish a threshold value for liver fat content between healthy children and those with non-alcoholic fatty liver disease (NAFLD) by using magnetic resonance imaging (MRI), with liver biopsy serving as a reference standard. METHODS: The study was approved by the local ethics committee, and written informed consent was obtained from all participants and their legal guardians before the study began. Twenty-seven children with NAFLD underwent liver biopsy to assess the presence of nonalcoholic steatohepatitis...
October 21, 2016: World Journal of Gastroenterology: WJG
Michael Pavlides, Rajarshi Banerjee, Elizabeth M Tunnicliffe, Catherine Kelly, Jane Collier, Lai Mun Wang, Kenneth A Fleming, Jeremy F Cobbold, Matthew D Robson, Stefan Neubauer, Eleanor Barnes
BACKGROUND AND AIMS: The diagnosis of non-alcoholic steatohepatitis (NASH) and fibrosis staging are central to non-alcoholic fatty liver disease (NAFLD) assessment. We evaluated multi-parametric magnetic resonance (MR) in the assessment of NASH and fibrosis using histology as standard in NAFLD. METHODS: Seventy one patients with suspected NAFLD were recruited within one month of liver biopsy. MR data were used to define the liver inflammation and fibrosis score (LIF 0-4)...
October 25, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Jean-Michel Petit, Jean-Pierre Cercueil, Romaric Loffroy, Damien Denimal, Benjamin Bouillet, Coralie Fourmont, Olivier Chevallier, Laurence Duvillard, Bruno Vergès
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is very frequent in type 2 diabetes with increased risk of further development of liver fibrosis. Animal studies have shown that GLP-1 receptor agonists may reduce liver lipogenesis. However, data in humans are scarce. OBJECTIVE: To study the effect of liraglutide 1.2 mg/d on liver fat content (LFC) in patients with uncontrolled type 2 diabetes and to evaluate the factors potentially associated with liraglutide-induced modification of LFC...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Stefan Z Lutz, Andreas Peter, Fausto Machicao, Apostolia Lamprinou, Jürgen Machann, Fritz Schick, Ingmar Königsrainer, Alfred Königsrainer, Andreas Fritsche, Harald Staiger, Hans-Ulrich Häring, Norbert Stefan, Konstantinos Kantartzis
CONTEXT/OBJECTIVE: Acute pharmacological inhibition of 11β-hydroxysteroid-dehydrogenase 1 (11β-HSD1), which converts cortisone into the much more potent cortisol in peripheral tissues, results in reduction of total-, visceral- and liver fat, but not of insulin resistance. We now investigated whether lifelong alterations of 11β-HSD1 activity similarly affect these cardiometabolic risk parameters, by studying single nucleotide polymorphisms (SNPs) in the 11β-HSD1-coding gene (HSD11B1)...
October 7, 2016: Journal of Clinical Endocrinology and Metabolism
Gavin Hamilton, Alexandra N Schlein, Michael S Middleton, Catherine A Hooker, Tanya Wolfson, Anthony C Gamst, Rohit Loomba, Claude B Sirlin
PURPOSE: To investigate the regional variability of adipose tissue triglyceride composition in vivo using (1) H MRS, examining potential confounders and corrections for artifacts, to allow for adipose tissue spectrum estimation. MATERIALS AND METHODS: (1) H magnetic resonance (MR) stimulated echo acquisition mode (STEAM) spectra were acquired in vivo at 3T from 340 adult patients (mean age 48.9 years, range 21-79 years; 172 males, 168 females; mean body mass index [BMI] 34...
August 29, 2016: Journal of Magnetic Resonance Imaging: JMRI
Nimantha M W de Alwis, Quentin M Anstee, Christopher P Day
Patients with nonalcoholic fatty liver disease (NAFLD) are asymptomatic and present with either unexplained abnormal liver blood tests or a bright liver on ultrasonography. Some patients will have normal liver blood tests raising the issue of whether patients with risk factors for NAFLD (diabetes and/or metabolic syndrome [MS]) should be screened for its presence with biomarkers, such as the fatty liver index (FLI). The diagnosis of NAFLD requires the exclusion of other causes of chronic liver disease and steatosis, especially heavy alcohol consumption and viral hepatitis particularly HCV genotype 3...
2016: Digestive Diseases
Rocío Gallego-Durán, Pablo Cerro-Salido, Emilio Gomez-Gonzalez, María Jesús Pareja, Javier Ampuero, María Carmen Rico, Rafael Aznar, Eduardo Vilar-Gomez, Elisabetta Bugianesi, Javier Crespo, Francisco José González-Sánchez, Reyes Aparcero, Inmaculada Moreno, Susana Soto, María Teresa Arias-Loste, Javier Abad, Isidora Ranchal, Raúl Jesús Andrade, Jose Luis Calleja, Miguel Pastrana, Oreste Lo Iacono, Manuel Romero-Gómez
There is a need, in NAFLD management, to develop non-invasive methods to detect steatohepatitis (NASH) and to predict advanced fibrosis stages. We evaluated a tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH and fibrosis detection by investigating patients with biopsy-proven NAFLD who underwent magnetic resonance (MR) protocols using 1.5T General Electric (GE) or Philips devices. Two imaging biomarkers (NASHMRI and FibroMRI) were developed, standardised and validated using area under the receiver operating characteristic curve (AUROC) analysis...
August 12, 2016: Scientific Reports
Pegah Golabi, Cameron T Locklear, Patrick Austin, Sophie Afdhal, Melinda Byrns, Lynn Gerber, Zobair M Younossi
AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease (NAFLD) patients. METHODS: Ovid-Medline, PubMed, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: "NASH", "NAFLD", "non-alcoholic steatohepatitis", "non-alcoholic fatty liver disease", "fat", "steatosis", "diet", "exercise", "MR spectroscopy" and "liver biopsy"...
July 21, 2016: World Journal of Gastroenterology: WJG
Jeffrey Cui, Len Philo, Phirum Nguyen, Heather Hofflich, Carolyn Hernandez, Ricki Bettencourt, Lisa Richards, Joanie Salotti, Archana Bhatt, Jonathan Hooker, William Haufe, Catherine Hooker, David A Brenner, Claude B Sirlin, Rohit Loomba
BACKGROUND & AIMS: Uncontrolled studies show sitagliptin, an oral DPP-4 inhibitor, may improve alanine aminotransferase and liver histology in non-alcoholic fatty liver disease (NAFLD) patients. We aimed to compare sitagliptin vs. the efficacy of a placebo in reducing liver fat measured by MRI-derived proton density-fat fraction (MRI-PDFF). METHODS: This randomized, double-blind, allocation-concealed, placebo-controlled trial included 50 NAFLD patients with prediabetes or early diabetes randomized to sitagliptin orally 100mg/day or placebo for 24weeks...
August 2016: Journal of Hepatology
Peter M Graffy, Perry J Pickhardt
Trends in obesity have continued to increase in the developed world over the past few decades, along with related conditions such as metabolic syndrome, which is strongly associated with this epidemic. Novel and innovative methods to assess relevant obesity-related biomarkers are needed to determine the clinical significance, allow for surveillance and intervene if appropriate. Aggregations of specific types of fat, specifically hepatic and visceral adiposity, are now known to be correlated with these conditions, and there are a variety of imaging techniques to identify and quantify their distributions and provide diagnostic information...
June 2016: British Journal of Radiology
Sonja Kinner, Scott B Reeder, Takeshi Yokoo
Conventional imaging modalities, including ultrasonography (US), computed tomography (CT), and magnetic resonance (MR), play an important role in the diagnosis and management of patients with nonalcoholic fatty liver disease (NAFLD) by allowing noninvasive diagnosis of hepatic steatosis. However, conventional imaging modalities are limited as biomarkers of NAFLD for various reasons. Multi-parametric quantitative MRI techniques overcome many of the shortcomings of conventional imaging and allow comprehensive and objective evaluation of NAFLD...
May 2016: Digestive Diseases and Sciences
Sara Heebøll, Martin Kreuzfeldt, Stephen Hamilton-Dutoit, Marianne Kjær Poulsen, Hans Stødkilde-Jørgensen, Holger Jon Møller, Niels Jessen, Kasper Thorsen, Ylva Kristina Hellberg, Steen Bønløkke Pedersen, Henning Grønbæk
OBJECTIVE: "The obesity epidemic" has led to an increase in obesity-related conditions including non-alcoholic fatty liver disease (NAFLD), for which effective treatments are in demand. The polyphenol resveratrol prevents the development of experimental NAFLD through modulation of cellular pathways involved in calorie restriction. We aimed to test the hypothesis that resveratrol alleviates NAFLD in a randomised, clinical trial. MATERIALS AND METHODS: A total of 28 overweight patients with transaminasemia and histological NAFLD were randomised 1:1 to placebo or resveratrol 1...
2016: Scandinavian Journal of Gastroenterology
Jeffrey Cui, Elhamy Heba, Carolyn Hernandez, William Haufe, Jonathan Hooker, Michael P Andre, Mark A Valasek, Hamed Aryafar, Claude B Sirlin, Rohit Loomba
UNLABELLED: Magnetic resonance elastography (MRE), an advanced magnetic resonance-based imaging technique, and acoustic radiation force impulse (ARFI), an ultrasound-based imaging technique, are accurate for diagnosing nonalcoholic fatty liver disease (NAFLD) fibrosis. However, no head-to-head comparisons between MRE and ARFI for diagnosing NAFLD fibrosis have been performed. We compared MRE versus ARFI head-to-head for diagnosing fibrosis in well-characterized patients with biopsy-proven NAFLD...
February 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Emil Achmad, Takeshi Yokoo, Gavin Hamilton, Elhamy R Heba, Jonathan C Hooker, Christopher Changchien, Michael Schroeder, Tanya Wolfson, Anthony Gamst, Jeffrey B Schwimmer, Joel E Lavine, Claude B Sirlin, Michael S Middleton
PURPOSE: To assess feasibility of and agreement between magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for estimating hepatic proton density fat fraction (PDFF) in children with known or suspected nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: Children were included in this study from two previous research studies in each of which three MRI and three MRS acquisitions were obtained. Sequence acceptability, and MRI- and MRS-estimated PDFF were evaluated...
October 2015: Abdominal Imaging
Daniella Braz Parente, Fernando Fernandes Paiva, Jaime Araújo Oliveira Neto, Lilian Machado-Silva, Fatima Aparecida Ferreira Figueiredo, Valeria Lanzoni, Carlos Frederico Ferreira Campos, Pedro Emmanuel Alvarenga Americano do Brasil, Marilia de Brito Gomes, Renata de Mello Perez, Rosana Souza Rodrigues
OBJECTIVE: To evaluate the capability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) to assess steatohepatitis and fibrosis determined by histopathology in type 2 diabetic patients. METHODS: Fifty-nine type 2 diabetic patients (49 women, 10 men; mean age, 54 ± 9 years) were submitted to liver biopsy for the evaluation of non-alcoholic fatty liver disease (NAFLD) and underwent DWI on a 3.0T MR system using 10 b values. Institutional approval and patient consent were obtained...
2015: PloS One
Ilkay S Idilman, Onur Keskin, Azim Celik, Berna Savas, Atilla Halil Elhan, Ramazan Idilman, Musturay Karcaaltincaba
BACKGROUND: Many imaging methods have been defined for quantification of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, studies comparing the efficiency of magnetic resonance imaging-proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and liver histology for quantification of liver fat content are limited. PURPOSE: To compare the efficiency of MRI-PDFF and MRS in the quantification of liver fat content in individuals with NAFLD...
March 2016: Acta Radiologica
Ilkay S Idilman, Ali Tuzun, Berna Savas, Atilla Halil Elhan, Azim Celik, Ramazan Idilman, Musturay Karcaaltincaba
PURPOSE: The purpose of the present study was to determine liver, pancreas, kidney, and vertebral fat deposition in NAFLD patients by proton density fat fraction (PDFF) using magnetic resonance imaging (MRI) and to evaluate the relationships among them. METHODS: A total of 41 biopsy-proven NAFLD patients underwent MRI-PDFF with IDEAL-IQ. MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling...
August 2015: Abdominal Imaging
Stergios A Polyzos, Panagiotis Nikolopoulos, Angeliki Stogianni, Iordanis Romiopoulos, Panagiotis Katsinelos, Jannis Kountouras
CONTEXT: Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. OBJECTIVES: The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging), nonalcoholic fatty liver disease fibrosis score and HSENSI (Homocysteine, serum glutamic oxaloacetic transaminase, Erythrocyte sedimentation rate, nonalcoholic steatohepatitis Index) in nonalcoholic steatohepatitis patients. METHODS: Thirteen adult patients with biopsy-proven nonalcoholic steatohepatitis, asymptomatic for gastrointestinal disease, underwent 13C urea breath test; Hp positive patients received eradication therapy until repeat test become negative...
July 2014: Arquivos de Gastroenterologia
An Tang, Ajinkya Desai, Gavin Hamilton, Tanya Wolfson, Anthony Gamst, Jessica Lam, Lisa Clark, Jonathan Hooker, Tanya Chavez, Brandon D Ang, Michael S Middleton, Michael Peterson, Rohit Loomba, Claude B Sirlin
PURPOSE: To evaluate the diagnostic performance of previously proposed high-specificity magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) thresholds for diagnosis of steatosis grade 1 or higher (PDFF threshold of 6.4%), grade 2 or higher (PDFF threshold of 17.4%), and grade 3 (PDFF threshold of 22.1%) by using histologic findings as a reference in an independent cohort of adults known to have or suspected of having nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: This prospective, cross-sectional, institutional review board-approved, HIPAA-compliant single-center study was conducted in an independent cohort of 89 adults known to have or suspected of having NAFLD who underwent contemporaneous liver biopsy...
February 2015: Radiology
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