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Periodontal ligament

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https://www.readbyqxmd.com/read/28091721/influence-of-tooth-dimension-on-the-initial-mobility-based-on-plaster-casts-and-x-ray-images-a-numerical-study
#1
Martin Hartmann, Cornelius Dirk, Susanne Reimann, Ludger Keilig, Anna Konermann, Andreas Jäger, Christoph Bourauel
AIMS: The goal was to determine the influence of different geometric parameters of the tooth on the initial tooth mobility and the position of the center of resistance employing numerical models based on scaled X-ray images and plaster casts. METHODS: The dimensions of tooth 21 were measured in 21 patients, using radiographs and dental casts. Length and mesiodistal width of the tooth were obtained from the X-ray image and the orovestibular diameter from the plaster cast...
January 13, 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/28081294/xenogeneic-bio-root-prompts-the-constructive-process-characterized-by-macrophage-phenotype-polarization-in-rodents-and-nonhuman-primates
#2
Hui Li, Jingjing Sun, Jie Li, Hefeng Yang, Xiangyou Luo, Jinlong Chen, Li Xie, Fangjun Huo, Tian Zhu, Weihua Guo, Weidong Tian
Tissue or organ regeneration using xenogeneic matrices is a promising approach to address the shortage of donor matrices for allotransplantation. Success of such approach has been demonstrated to correlate with macrophage-mediated fibrotic homeostasis and tissue remodeling. The previous studies have demonstrated that treated dentin matrix (TDM) could be a suitable bioactive substrate for allogeneic tooth root regeneration. This study constructed xenogeneic bioengineered tooth root (bio-root) via a combination of porcine TDM (pTDM) with allogeneic dental follicle cells (DFCs)...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28078876/comparative-molecular-analysis-of-bacterial-species-associated-with-periodontal-disease
#3
V De Iuliis, S Ursi, L M Di Tommaso, M Caruso, A Marino, S D Ercole, S Caputi, B Sinjari, F Festa, M Macri, S Martinotti, G Vitullo, E Toniato
Periodontal disease is an inflammatory disorder affecting the supporting teeth structures, including gingiva, periodontal ligament and alveolar bone, causing loss of connective tissue, reabsorption of alveolar bone and formation of periodontal pockets. The aim of this study is to find a correlation between bacterial growth and periodontal disease. Fifty-seven patients aged between 21 and 65 years, median age 46 years, were enrolled. According to gingival pocket depth, ranging from 3 to 7 mm, patients were divided into two groups: the first (30 patients, 53%) with deep pockets ³ 5 mm and the second (27 patients, 47%) less than 5 mm...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078846/mir-2861-is-involved-in-osteogenic-commitment-of-human-periodontal-ligament-stem-cells-grown-onto-3d-scaffold
#4
F Diomede, I Merciaro, S Martinotti, M F X B Cavalcanti, S Caputi, E Mazzon, O Trubiani
miR-2861 endorsing osteoblast differentiation through the overexpression of Runt-related transcription factor 2 (RUNX2) protein has been recently described. In this study we evaluated: the performance of living construct, composed by human Periodontal Ligament Stem Cells (hPDLSCs) and 3D scaffold (EXg), and the behaviour of miR-2861/RUNX2 expression pathway on the osteogenic commitment. Human PDLSCs were seeded with and without EXg scaffold and cultured under basal and osteogenic conditions. Morphological features, adhesiveness and differentiation abilities were analysed using scanning electron and confocal laser scanning microscopy...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28071181/cd8-t-cells-mediate-the-regenerative-pth-effect-in-hpdl-cells-via-wnt10b-signaling
#5
Michael Wolf, Stefan Lossdörfer, Jana Marciniak, Piero Römer, Christian Kirschneck, Rogerio Craveiro, James Deschner, Andreas Jäger
It was the aim of the present investigation to examine whether the stimulating effect of parathyroid hormone (PTH) on human periodontal ligament (hPDL) cell proliferation and differentiation would be enhanced by hPDL/T-cell interaction involving Wnt10b signaling as a mediating pathway. hPDL cells were cultured from healthy premolar tissues of three adolescent orthodontic patients and exposed to PTH(1-34) in monocultures or co-cultures with CD8(+) T cells. At harvest, proliferation, alkaline phosphatase-specific activity (ALP), and osteocalcin production were determined by immunofluorescence cytochemistry, real-time PCR, biochemical assay, and ELISA...
November 2016: Innate Immunity
https://www.readbyqxmd.com/read/28068493/bmp1-and-tll1-are-required-for-maintaining-periodontal-homeostasis
#6
J Wang, D Massoudi, Y Ren, A M Muir, S E Harris, D S Greenspan, J Q Feng
Mutations in bone morphogenetic protein 1 (BMP1) in humans or deletion of BMP1 and related protease tolloid like 1 (TLL1) in mice lead to osteogenesis imperfecta (OI). Here, we show progressive periodontal defects in mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to play key roles in normal alveolar bone formation), significant loss in alveolar bone mass ( P < 0.01), and a sharp reduction in cellular cementum. Molecular mechanism studies revealed a dramatic increase in the uncleaved precursor of type I collagen (procollagen I) and a reduction in dentin matrix protein 1 (DMP1), which is partially responsible for defects in extracellular matrix (ECM) formation and mineralization...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28066875/evaluating-the-effects-of-consolidation-on-intrusion-and-retraction-using-temporary-anchorage-devices-a-fem-study
#7
Monica Namburi, Sleevaraju Nagothu, Chetan S Kumar, N Chakrapani, C H Hanumantharao, Supradeep K Kumar
BACKGROUND: Extraction of premolars and retracting the anterior teeth using mini-implants and anterior retraction hooks became advent now a day. In such treatments, consolidation of arches is not done in regular practice. So, the present study is concentrated on effects of consolidation in two implant and three implant combinations of retraction and intrusion. METHODS: A three-dimensional FEM model of maxillary teeth and periodontal ligament housed in the alveolar bone with the first premolars extracted is generated with appropriate number of elements and nodes...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28061389/in-vitro-proliferation-of-periodontal-ligament-like-tissue-on-extracted-teeth
#8
T Iwata, C Mino, T Kawata
OBJECTIVE: Transplantation of autologous teeth is a routine component of orthodontic treatment. The aim of this study was to develop a method for the regeneration of damaged periodontal ligament (PDL) on extracted teeth using a three-dimensional culture system. DESIGN: We used the maxillary first premolars or third molars extracted from patients for orthodontic treatment. The extracted teeth were stained with toluidine blue to measure the residual PDL area. After confirming damage of the periodontal tissue on the root surface of the extracted teeth, we tried to regenerate the periodontal tissue...
November 30, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/28060561/aspirin-blocks-orthodontic-relapse-via-inhibition-of-cd4-t-lymphocytes
#9
Y Liu, T Zhang, C Zhang, S S Jin, R L Yang, X D Wang, N Jiang, Y H Gan, X X Kou, Y H Zhou
Immunologic response plays an important role in orthodontic tooth movement (OTM) and relapse. Nonsteroidal anti-inflammatory drugs, such as aspirin, affect immune cells and clinical orthodontic treatment. However, the mechanisms by which nonsteroidal anti-inflammatory drugs regulate immune cells to affect orthodontic relapse are unclear. In this study, male Sprague-Dawley rats were grouped as relapse and relapse + aspirin for 10 d after 14 d of OTM. Silicone impressions of the rats' maxillary dentitions were obtained to record the distance of OTM at the indicated time point...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28053317/jawbone-microenvironment-promotes-periodontium-regeneration-by-regulating-the-function-of-periodontal-ligament-stem-cells
#10
Bin Zhu, Wenjia Liu, Yihan Liu, Xicong Zhao, Hao Zhang, Zhuojing Luo, Yan Jin
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052093/bone-morphogenetic-protein-9-enhances-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-via-the-jnk-pathway
#11
Pei Wang, Yanen Wang, Weizhong Tang, Xingxing Wang, Yanan Pang, Su Yang, Yibo Wei, Haochen Gao, Dalin Wang, Zhizhong Cao
Bone morphogenetic protein-9 (BMP9) shows great osteoinductive potential in bone regeneration. Periodontal ligament stem cells (PDLSCs) with multi-differentiation capability and low immunogenicity are increasingly used as seed cells for periodontal regenerative therapies. In the present study, we investigated the potent osteogenic activity of BMP9 on human PDLSCs (hPDLSCs), in which the c-Jun N-terminal kinase (JNK) pathway is possibly involved. Our results showed that JNK inhibition by the specific inhibitor SP600125 or adenovirus expressing small interfering RNA (siRNA) targeting JNK (AdR-si-JNK) significantly decreased BMP9-induced gene and protein expression of early and late osteogenic markers, such as runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP), osteopontin (OPN), and osteocalcin (OCN), in hPDLSCs...
2017: PloS One
https://www.readbyqxmd.com/read/28050317/association-between-dental-implants-in-the-posterior-region-and-traumatic-occlusion-in-the-adjacent-premolars-a-long-term-follow-up-clinical-and-radiographic-analysis
#12
Jae-Hong Lee, Helen Hye-In Kweon, Seong-Ho Choi, Young-Taek Kim
PURPOSE: The aim of this retrospective study was to determine the association between dental implants in the posterior region and traumatic occlusion in the adjacent premolars, using data collected during from 2002 to 2015. METHODS: Traumatic occlusion in the adjacent premolars was assessed by examining clinical parameters (bleeding on probing, probing pocket depth, fremitus, and tooth mobility) and radiographic parameters (loss of supporting bone and widening of the periodontal ligament space) over a mean follow-up of 5 years...
December 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28044198/meloxicam-medication-reduces-orthodontically-induced-dental-root-resorption-and-tooth-movement-velocity-a-combined-in-vivo-and-in-vitro-study-of-dental-periodontal-cells-and-tissue
#13
Christian Kirschneck, Matthias Meier, Kathrin Bauer, Peter Proff, Jochen Fanghänel
Non-steroidal anti-inflammatory drugs (NSAID) are used to alleviate pain sensations during orthodontic therapy but are also assumed to interfere with associated pseudo-inflammatory reactions. In particular, the effects of partially selective COX-2 inhibition over the constitutively expressed COX-1 (11:1) on periodontal cells and tissue, as induced by the NSAID meloxicam, remain unclear. We investigate possible adverse side-effects and potentially useful beneficial effects during orthodontic therapy and examine underlying cellular and tissue reactions...
January 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28042273/gingival-crevicular-fluid-periostin-levels-in-chronic-periodontitis-patients-following-nonsurgical-periodontal-treatment-with-low-level-laser-therapy
#14
Dhanangchaayan Kumaresan, Aruna Balasundaram, Vanaja Krishna Naik, Deva Priya Appukuttan
OBJECTIVE: Periostin is a matricellular protein highly expressed in periosteum, periodontal ligament and is essential for tissue integrity and maturation. It plays a role in collagen fibrillogenesis and is downregulated in periodontal disease. Biostimulation utilizing low-level laser therapy (LLLT) influences periodontal ligament fibroblast proliferation. This study was conducted with the objective of estimating periostin levels in chronic periodontitis (CP) patients following LLLT as an adjunct to root surface debridement (RSD)...
October 2016: European Journal of Dentistry
https://www.readbyqxmd.com/read/28042260/effect-of-platelet-rich-plasma-concentrations-on-the-proliferation-of-periodontal-cells-an-in-vitro-study
#15
Sara Tavassoli-Hojjati, Mandana Sattari, Tayebeh Ghasemi, Rahil Ahmadi, Abbas Mashayekhi
OBJECTIVE: The purpose of this study was to evaluate the effect of different concentrations of platelet-rich plasma (PRP) on the proliferation of undifferentiated periodontal ligament (PDL) fibroblasts. MATERIALS AND METHODS: The undifferentiated PDL fibroblasts were obtained from two healthy human premolar teeth and cultured in Dulbecco's modified Eagle's medium. Cell wells were divided into five groups. Experimental groups received 0.1%, 5%, or 50% PRP; the positive and negative control groups were cultured in fetal bovine serum (FBS) 12% and in a medium without FBS 12%, respectively...
October 2016: European Journal of Dentistry
https://www.readbyqxmd.com/read/28035302/analysis-of-the-priority-of-anatomic-structures-according-to-the-diagnostic-task-in-cone-beam-computed-tomographic-images
#16
Jin-Woo Choi
PURPOSE: This study was designed to evaluate differences in the required visibility of anatomic structures according to the diagnostic tasks of implant planning and periapical diagnosis. MATERIALS AND METHODS: Images of a real skull phantom were acquired under 24 combinations of different exposure conditions in a cone-beam computed tomography scanner (60, 70, 80, 90, 100, and 110 kV and 4, 6, 8, and 10 mA). Five radiologists evaluated the visibility of anatomic structures and the image quality for diagnostic tasks using a 6-point scale...
December 2016: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28035300/review-of-common-conditions-associated-with-periodontal-ligament-widening
#17
REVIEW
Hamed Mortazavi, Maryam Baharvand
PURPOSE: The aim of this article is to review a group of lesions associated with periodontal ligament (PDL) widening. MATERIALS AND METHODS: An electronic search was performed using specialized databases such as Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus to find relevant studies by using keywords such as "periodontium", "periodontal ligament", "periodontal ligament space", "widened periodontal ligament", and "periodontal ligament widening"...
December 2016: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28027709/conditioned-medium-from-periodontal-ligament-stem-cells-enhances-periodontal-regeneration
#18
Mizuki Nagata, Kengo Iwasaki, Keiko Akazawa, Motohiro Komaki, Naoki Yokoyama, Yuichi Izumi, Ikuo Morita
Periodontal disease is one of the most common infectious diseases in adults and is characterized by the destruction of tooth-supporting tissues. Mesenchymal stem cells (MSCs) comprise the mesoderm-originating stem cell population, which has been studied and used for cell therapy. However, because of the lower rate of cell survival after MSC transplantation in various disease models, paracrine factions of MSCs have been receiving increased attentions as a regenerative mechanism. The aim of this study was to investigate the regenerative potential of transplanted of conditioned medium (CM) obtained from cultured periodontal ligament stem cells (PDLSCs), the adult stem cell population in tooth-supporting tissues, using a rat periodontal defect model...
December 27, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28013443/periostin-is-required-for-matricellular-localization-of-ccn3-in-periodontal-ligament-of-mice
#19
Issei Takayama, Hideyuki Tanabe, Takashi Nishiyama, Harumi Ito, Norio Amizuka, Minqi Li, Ken-Ichi Katsube, Isao Kii, Akira Kudo
CCN3 is a matricellular protein that belongs to the CCN family. CCN3 consists of 4 domains: insulin-like growth factor-binding protein-like domain (IGFBP), von Willebrand type C-like domain (VWC), thrombospondin type 1-like domain (TSP1), and the C-terminal domain (CT) having a cysteine knot motif. Periostin is a secretory protein that binds to extracellular matrix proteins such as fibronectin and collagen. In this study, we found that CCN3 interacted with periostin. Immunoprecipitation analysis revealed that the TSP1-CT interacted with the 4 repeats of the Fas 1 domain of periostin...
December 24, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28004379/die-intraligament%C3%A3-re-an%C3%A3-sthesie-eine-wertvolle-alternative-zu-konventionellen-techniken
#20
Jan Samuel Schenkel, Heinz-Theo Lübbers, Philipp Metzler
Reliable analgesia can nowadays be achieved with several techniques and different anesthetic solutions, but side effects may be encountered. Severe and potentially fatal cardiovascular reactions can be the result of an intravascular injection. An easy to use, effective and safe alternative is the periodontal ligament injection. Nerve damage or cardiovascular side effects are not to be expected. This type of anesthesia can be of advantage for many dental procedures. With new devices like the computer-controlled local anesthetic delivery system, the periodontal ligament injection is a convenient way of local anesthesia for both patient and dentist...
2016: Swiss Dental Journal
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