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Periodontal ligament

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https://www.readbyqxmd.com/read/28444165/proinflammatory-mediators-related-to-orthodontically-induced-periapical-root-resorption-in-rat-mandibular-molars
#1
Yoshiro Matsumoto, Siripen Sringkarnboriboon, Takashi Ono
Objectives: The early phase of orthodontic tooth movement involves acute inflammatory response that may induce bone resorption. The aim of this study was to localize and quantify cells in the periodontium expressing proinflammatory mediators during orthodontically induced periapical root resorption of the rat mandibular molars. Materials and methods: The levels of proinflammatory cytokines interleukin-1 (IL-1) α and β, tumor necrosis factor-α (TNF-α), inflammatory enzymes cyclooxygenase (COX) 1 and 2, and their product prostaglandin E2 (PGE2) in the root resorption site were compared to those in the corresponding area of the untreated periodontal ligament (PDL) of physiologically drifting teeth...
April 22, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28440742/leptin-overexpression-in-bone-marrow-stromal-cells-promotes-periodontal-regeneration-in-a-rat-model-of-osteoporosis
#2
Baoyu Zheng, Jun Jiang, Yuling Chen, Minkui Lin, Zhibin Du, Yin Xiao, Kai Luo, Fuhua Yan
BACKGROUND: Osteoporosis (OP) is associated with widespread periodontitis and impaired periodontal healing. However, there is a lack of information about the outcomes of regenerative approaches under the influence of OP. This study investigated the effect of leptin (LEP) overexpression on the regenerative potential of bone marrow stromal cells (BMSCs) in an osteoporotic rat periodontal fenestration defect model. METHODS: Rat BMSCs were transfected with adenoviruses harboring the human (h) LEP gene...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28437177/periodontal-derived-mesenchymal-cell-sheets-promote-periodontal-regeneration-in-inflammatory-microenvironment
#3
Shujuan Guo, Jian Kang, Baohui Ji, Weihua Guo, Yi Ding, Yafei Wu, Weidong Tian
In this study, we investigated the periodontal regenerative potential of dental follicle cell (DFC) sheets and periodontal ligament cell (PDLC) sheets in the simulating inflammatory microenvironment of periodontitis, in order to confirm their regenerative potential for clinical application and explain the possible mechanism. The biological characteristics of DFC sheets and PDLC sheets were explored in lipopolysaccharid from Porphyromonas gingivalis (P. gingivalis LPS) induced inflammation microenvironment in vitro, then cell sheets were transplanted into canine periodontal defects with experimental periodontitis in situ for three months...
February 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28435460/size-dependent-effects-of-gold-nanoparticles-on-osteogenic-differentiation-of-human-periodontal-ligament-progenitor-cells
#4
Yangheng Zhang, Na Kong, Yuanchao Zhang, Wenrong Yang, Fuhua Yan
Gold nanoparticles (AuNPs) have been reported to promote osteogenic differentiation of mesenchymal stem cells and osteoblasts, but little is known about their effects on human periodontal ligament progenitor cells (PDLPs). In this study, we evaluated the effects of AuNPs with various diameters (5, 13 and 45 nm) on the osteogenic differentiation of PDLPs and explored the underlying mechanisms. 5 nm AuNPs reduced the alkaline phosphatase activity, mineralized nodule formation and expression of osteogenic genes, while 13 and 45 nm AuNPs increased these osteogenic markers...
2017: Theranostics
https://www.readbyqxmd.com/read/28435369/in-vitro-comparative-evaluation-of-different-storage-media-hank-s-balanced-salt-solution-propolis-aloe-vera-and-pomegranate-juice-for-preservation-of-avulsed-tooth
#5
Prashant Babaji, Mahesh Melkundi, Raghu Devanna, B S Suresh, Vishwajit Rampratap Chaurasia, P V Gopinath
OBJECTIVES: Prognosis of the avulsed teeth is mostly affected by extraoral dry period and storage medium used to store teeth before reimplantation. However, ability of storage media can affect cell viability and success of treatment. Various storage media were tried with some success. The present study was undertaken to comparatively evaluate the efficacy of hank's balanced salt solution (HBSS), propolis, Aloe vera, and pomegranate juice (PJ) in preserving the vitality of periodontal ligament (PDL) cells of avulsed teeth...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434685/influence-of-inhomogeneous-dental-posts-on-stress-distribution-in-tooth-root-and-interfaces-three-dimensional-finite-element-analysis
#6
Mojtaba Mahmoudi, Ali Reza Saidi, Parviz Amini, Maryam Alsadat Hashemipour
STATEMENT OF PROBLEM: In post-core crown restorations, the use of flexible posts concentrates stresses at the dentin and the use of stiff posts concentrates stresses at the interfaces. A class of inhomogeneous materials (called functionally graded materials) has been proposed for posts to resolve the weaknesses of both flexible and rigid posts. PURPOSE: The purpose of this in vitro study was to design an inhomogeneous post and investigate its influence on the stress distribution of post-core crown restorations...
April 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28434170/establishment-and-characterization-of-novel-epithelial-like-cell-lines-derived-from-human-periodontal-ligament-tissue-in-vitro
#7
Kallapat Tansriratanawong, Hiroshi Ishikawa, Junko Toyomura, Soh Sato
In this study, novel human-derived epithelial-like cells (hEPLCs) lines were established from periodontal ligament (PDL) tissues, which were composed of a variety of cell types and exhibited complex cellular activities. To elucidate the putative features distinguishing these from epithelial rest of Malassez (ERM), we characterized hEPLCs based on cell lineage markers and tight junction protein expression. The aim of this study was, therefore, to establish and characterize hEPLCs lines from PDL tissues. The hEPLCs were isolated from PDL of third molar teeth...
April 22, 2017: Human Cell
https://www.readbyqxmd.com/read/28425840/standardization-of-criteria-defining-periodontal-ligament-stem-cells
#8
P M Bartold, S Gronthos
No abstract text is available yet for this article.
May 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28422843/hypoxia-regulated-human-periodontal-ligament-cells-via-wnt-%C3%AE-catenin-signaling-pathway
#9
Zhili Xiao, Yineng Han, Yan Zhang, Xiaonan Zhang
BACKGROUND: The aim of this study is to investigate the effects of hypoxia on the proliferation, morphology, migration ability, hypoxia inducible factor (HIF) 1 (HIF-1) expression, and the relationship with Wnt/β-catenin signaling of human periodontal ligament cells (hPDLCs) in vitro. METHODS: hPDLCs (4th passage) cultured by the tissue culture method were randomly assigned to slight (5% O2), severe hypoxia (1% O2) groups, and the control (21% O2) group, respectively...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28416306/histologic-findings-of-a-human-immature-revascularized-regenerated-tooth-with-symptomatic-irreversible-pulpitis
#10
Chufang Peng, Yuming Zhao, Wenjun Wang, Yuan Yang, Man Qin, Lihong Ge
INTRODUCTION: Pulp revascularization/regeneration in immature permanent teeth with necrotic pulp and/or apical periodontitis is an effective approach for inducing root maturation. Previous histologic studies showed cementoid/osteoid tissue and/or periodontal ligament-like tissue formed within the root canals. This case report describes the histologic findings of a human symptomatic irreversible pulpitis immature permanent tooth with most of the pulp removed after a revascularization/regeneration procedure...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28416159/new-finite-element-study-protocol-clinical-simulation-of-orthodontic-tooth-movement
#11
Antoine Bouton, Yohann Simon, Florent Goussard, Luciano Teresi, Vittorio Sansalone
The aim of this work was to model tooth movement in a more clinically-exact fashion, thanks to the use of new IT tools and imaging systems (cone-beam). Image segmentation and 3D reconstruction now enable us to model the anatomy realistically, while finite element (FE) analysis makes it possible to evaluate stresses and their distribution on the level of the tooth, the periodontal ligament (PDL) and the alveolar bone when a force is applied. The principle is to monitor tooth movement by obtaining optical impressions at each stage of treatment...
April 13, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28412975/effect-of-cryopreservation-on-proliferation-and-differentiation-of-periodontal-ligament-stem-cell-sheets
#12
Mengying Li, Cheng Feng, Xiuge Gu, Qin He, Fulan Wei
BACKGROUND: Cryopreservation has been extensively applied to the long-term storage of a diverse range of biological materials. However, no comprehensive study is currently available on the cryopreservation of periodontal ligament stem cell (PDLSC) sheets which have been suggested as excellent transplant materials for periodontal tissue regeneration. The aim of this study is to investigate the effect of cryopreservation on the structural integrity and functional viability of PDLSC sheets...
April 17, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28412790/-a-preliminary-study-of-three-dimensional-bio-printing-by-polycaprolactone-and-periodontal-ligament-stem-cells
#13
J Xu, M Hu
Objective: To investigate the technical scheme of three-dimensional (3D) bio-printing by polycaprolactone (PCL) and periodontal ligament stem cells (PDLSC). Methods: To manufacture a 3D bio-printing body, PDLSC were used as seed cells, and polycaprolactone (PCL) was used as the 3D printing scaffold material. Print size was designed at 13.0 mm×13.0 mm, and mesh size was 0.25 mm×0.25 mm (group A) and 0.75 mm×0.75 mm (group B). Cell counting kit-8 was used to detect the proliferation of PDLSC on day 1, day 3 and day 5 respectively...
April 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28408960/molecular-characterization-and-function-of-tenomodulin-a-marker-of-tendons-and-ligaments-that-integrate-musculoskeletal-components
#14
REVIEW
Chisa Shukunami, Yuki Yoshimoto, Aki Takimoto, Hiroshi Yamashita, Yuji Hiraki
Tendons and ligaments are dense fibrous bands of connective tissue that integrate musculoskeletal components in vertebrates. Tendons connect skeletal muscles to the bone and function as mechanical force transmitters, whereas ligaments bind adjacent bones together to stabilize joints and restrict unwanted joint movement. Fibroblasts residing in tendons and ligaments are called tenocytes and ligamentocytes, respectively. Tenomodulin (Tnmd) is a type II transmembrane glycoprotein that is expressed at high levels in tenocytes and ligamentocytes, and is also present in periodontal ligament cells and tendon stem/progenitor cells...
November 2016: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28407986/intravenous-bisphosphonate-therapy-does-not-thicken-cementum-or-change-periodontal-ligaments-of-cancer-patients
#15
Mariana de Pauli Paglioni, Wagner Gomes Silva, Juliana Pereira, César Augusto Migliorati, Marcio Ajudarte Lopes, Oslei Paes de Almeida, Mario Fernando Goes, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Alan Roger Santos-Silva
OBJECTIVE: To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. STUDY DESIGN: Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy...
May 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28403356/fluoxetine-effects-on-periodontogenesis-histomorphometrical-and-immunohistochemical-analyses-in-rats
#16
Luciana Silva Regueira, Priscylla Gonçalves Correia Leite de Marcelos, Isabela Maria Santiago-Jaegger, Danyel Elias da Cruz Perez, Joaquim Evêncio, Liriane Baratella-Evêncio
Objective: This study aimed to assess the effects of fluoxetine, a selective serotonin reuptake inhibitor, on the formation of the periodontal ligament during pregnancy and lactation in rat pups. Material and Methods: Twelve pregnant rats of Wistar lineage were divided into four study groups. In the control group, 0.9% sodium chloride solution was administered orally, throughout the entire period of the 21 days of pregnancy (CG group) and in the CGL group, it was administrated during pregnancy and lactation (from day 1 of pregnancy to the 21st day after birth)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28403352/effects-of-grape-seed-extract-on-periodontal-disease-an-experimental-study-in-rats
#17
Feyza Otan Özden, Elif Eser Sakallioğlu, Umur Sakallioğlu, Bülent Ayas, Züleyha Erişgin
Objective: This study aimed to demonstrate the effect of grape seed extract (GSE) on periodontitis. Material and Methods: Ligature induced periodontitis was created in 40 rats and they were assigned to four equal groups. One group was fed laboratory diet (group A) while three groups received GSE additionally. Silk ligatures were placed around the cervical area of the mandibular first molars for four weeks to induce periodontitis. The GSE groups were reallocated regarding GSE consumption as: for two weeks before ligation (group B; totally eight weeks), from ligation to two weeks after removal of the ligature (group C; totally six weeks), and for two weeks from ligature removal (group D; totally two weeks)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28401196/periodontal-ligament-stem-cells-regulate-apoptosis-of-neutrophils
#18
Qing Wang, Gang Ding, Xin Xu
Periodontal ligament stem cells (PDLSCs) are promising cell resource for the cell-based therapy for periodontitis and regeneration of bio-root. In this study, we investigated the effect of PDLSCs on neutrophil, a critical constituent of innate immunity, and the underlying mechanisms. The effect of PDLSCs on the proliferation and apoptosis of resting neutrophils and IL-8 activated neutrophils was tested under cell-cell contact culture and Transwell culture, with or without anti-IL-6 neutralizing antibody. We found that PDLSCs could promote the proliferation and reduce the apoptosis of neutrophils whether under cell-cell contact or Transwell culture...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28398106/interleukin-12-il-12-induces-receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-expression-by-human-periodontal-ligament-cells
#19
Benjar Issaranggun Na Ayuthaya, Vincent Everts, Prasit Pavasant
BACKGROUND: An increased level of the pro-inflammatory cytokine interleukin-12 (IL-12) correlates with the severity of periodontitis. Yet, a possible role of IL-12 in periodontal disease has not been clarified. The aim of this study was to investigate whether IL-12 affects the expression of receptor activator of nuclear factor kappa-B ligand (RANKL), a potent osteoclast-stimulating factor, by human periodontal ligament (hPDL) cells. METHODS: To determine the effect of IL-12, hPDL cells were incubated with recombinant human IL-12 (p70) in a dose- (0-10 ng/ml) and time-dependent manner...
March 3, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28396689/corrigendum-to-fabrication-of-core-shell-pei-pbmp2-plga-electrospun-scaffold-for-gene-delivery-to-periodontal-ligament-stem-cells
#20
Qiao Xie, Lie-Ni Jia, Hong-Yu Xu, Xiang-Gang Hu, Wei Wang, Jun Jia
[This corrects the article DOI: 10.1155/2016/5385137.].
2017: Stem Cells International
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