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Periodontal ligament

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https://www.readbyqxmd.com/read/28212613/porphyromonas-gingivalis-can-invade-periodontal-ligament-stem-cells
#1
Chunling Pan, Junchao Liu, Hongyan Wang, Jia Song, Lisi Tan, Haijiao Zhao
BACKGROUND: Porphyromonas gingivalis is strongly associated with the development, progression, severity and recurrence of periodontitis. Periodontal ligament stem cells (PDLSCs) play an important role in the maintenance of periodontal tissue self-renewal and repair. The purpose of this study was to investigate the ability of P. gingivalis to infect PDLSCs using an in vitro monolayer model. METHODS: We separated and cultured primary PDLSCs using the tissue block with limiting dilution method...
February 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28208578/role-of-cortico-cancellous-heterologous-bone-in-human-periodontal-ligament-stem-cell-xeno-free-culture-studied-by-synchrotron-radiation-phase-contrast-microtomography
#2
Serena Mazzoni, Sara Mohammadi, Giuliana Tromba, Francesca Diomede, Adriano Piattelli, Oriana Trubiani, Alessandra Giuliani
This study was designed to quantitatively demonstrate via three-dimensional (3D) images, through the Synchrotron Radiation Phase-Contrast Microtomography (SR-PhC-MicroCT), the osteoinductive properties of a cortico-cancellous scaffold (Osteobiol Dual Block-DB) cultured with human Periodontal Ligament Stem Cells (hPDLSCs) in xeno-free media. In vitro cultures of hPDLSCs, obtained from alveolar crest and horizontal fibers of the periodontal ligament, were seeded onto DB scaffolds and cultured in xeno-free media for three weeks...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28207939/chemokine-in-inflamed-periodontal-tissues-activates-healthy-periodontal-ligament-stem-cell-migration
#3
Jung-Seok Lee, Jong-Bin Lee, Jae-Kook Cha, Eun-Young Choi, So-Yon Park, Kyoo-Sung Cho, Chang-Sung Kim
AIM: The present study aimed to characterize the expression pattern of chemokines obtained from inflamed periodontal defects and to determine the characteristics of human periodontal-ligament stem cells (hPDLSCs) migrated by each specific chemokine. MATERIALS AND METHODS: Both inflamed and healthy periodontal tissues were obtained from periodontitis patients (n=11), and the chemokine expression levels were analyzed. The periodontal-tissue-specific chemokines were applied to healthy hPDLSCs from extracted teeth (n=3), with FGF-2 acting as a positive control...
February 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28203004/-a-method-for-rapid-extracting-three-dimensional-root-model-of-vivo-tooth-from-cone-beam-computed-tomography-data-based-on-the-anatomical-characteristics-of-periodontal-ligament
#4
Y J Zhao, S W Wang, Y Liu, Y Wang
OBJECTIVE: To explore a new method for rapid extracting and rebuilding three-dimensional (3D) digital root model of vivo tooth from cone beam computed tomography (CBCT) data based on the anatomical characteristics of periodontal ligament, and to evaluate the extraction accuracy of the method. METHODS: In the study, 15 extracted teeth (11 with single root, 4 with double roots) were collected from oral clinic and 3D digital root models of each tooth were obtained by 3D dental scanner with a high accuracy 0...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28202998/-comparative-study-of-proliferative-and-periodontal-differentiation-propensity-of-induced-pluripotent-stem-cells-at-different-passages
#5
J W Li, X H Yin, Q X Luan
OBJECTIVE: To compare the proliferative and periodontal specific differentiation abilities of induced pluripotent stem cells (iPSCs) at different passages, and to investigate whether long term culturing would have a negative influence on their proliferation and specific differentiation capacity, thus providing a theoretical basis for further in-depth research on periodontal regeneration and the possible clinical applications of iPSCs. METHODS: IPSCs derived from human gingival fibroblasts at passages 5, 10, 15 and 20 were recovered and cultured in vitro...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199848/discoidin-domain-receptor-1-mediates-myosin-dependent-collagen-contraction
#6
Nuno M Coelho, Pamma D Arora, Sander van Putten, Stellar Boo, Petar Petrovic, Alyna Xue Lin, Boris Hinz, Christopher A McCulloch
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion receptor that mediates cell migration through association with non-muscle myosin IIA (NMIIA). Because DDR1 is implicated in cancer fibrosis, we hypothesized that DDR1 interacts with NMIIA to enable collagen compaction by traction forces. Mechanical splinting of rat dermal wounds increased DDR1 expression and collagen alignment. In periodontal ligament of DDR1 knockout mice, collagen mechanical reorganization was reduced >30%. Similarly, cultured cells with DDR1 knockdown or expressing kinase-deficient DDR1d showed 50% reduction of aligned collagen...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28198538/role-of-pin1-on-in-vivo-periodontal-tissue-and-in-vitro-cells
#7
K-H Park, E-H Cho, W-J Bae, H-S Kim, H-C Lim, Y-D Park, M-O Lee, E-S Cho, E-C Kim
BACKGROUND: Although expression of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) was reported in bone tissue, the precise role of PIN1 in periodontal tissue and cells remain unclear. MATERIAL & METHODS: To elucidate the roles of PIN1 in periodontal tissue, its expression in periodontal tissue and cells, and effects on in vitro 4 osteoblast differentiation and the underlying signaling mechanisms were evaluated. RESULTS: PIN1 was expressed in mouse periodontal tissues including periodontal ligament cells (PDLCs), cementoblasts and osteoblasts at the developing root formation stage (postnatal, PN14) and functional stage of tooth (PN28)...
February 15, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28195408/microrna-22-promoted-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-by-targeting-hdac6
#8
Guang-Qi Yan, Xue Wang, Fan Yang, Min-Liang Yang, Guo-Kun Wang, Qing Zhou
Stem cells transplantation is a promising therapy strategy for accelerating periodontal regeneration and reconstruction. Genetic modification could induce stem cells directional differentiation to facilitate recovery of physiological functions. In this study, we investigated the role and mechanism of miR-22 on human periodontal ligament stem cells (PDLSCs). Firstly, a cellular model of osteogenic differentiation was first established by osteogenic inductive cocktail. Real-time PCR determined that expression of miR-22 was significantly increased during PDLSCs osteogenic differentiation...
February 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28194495/florid-cemento-osseous-dysplasia-review-of-an-uncommon-fibro-osseous-lesion-of-the-jaw-with-important-clinical-implications
#9
REVIEW
Sarah Fenerty, Wei Shaw, Rahul Verma, Ali B Syed, Riya Kuklani, Jie Yang, Sayed Ali
Florid cemento-osseous dysplasia (FCOD) is a rare, benign, multifocal fibro-osseous dysplastic process affecting tooth-bearing areas of the jaw, characterized by replacement of normal trabecular bone with osseous tissue and dense acellular cementum in a fibrous stroma. It is one clinicopathologic variant in a spectrum of related non-neoplastic fibro-osseous lesions known as cemento-osseous dysplasias (CODs), thought to arise from elements of the periodontal ligament. Diagnosis primarily relies upon radiographic and clinical findings; unnecessary biopsy should be avoided, as inoculation with oral pathogens may precipitate chronic infection in these hypovascular lesions...
February 13, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28194401/clinical-application-of-cone-beam-computed-tomography-of-the-rabbit-head-part-2-dental-disease
#10
G G Riggs, Derek D Cissell, Boaz Arzi, David C Hatcher, Philip H Kass, Amy Zhen, Frank J M Verstraete
Domestic rabbits are increasing in popularity as household pets; therefore, veterinarians need to be familiar with the most common diseases afflicting rabbits including dental disease. Current diagnostic approaches include gross oral examination, endoscopic oral examination, skull radiography, and computed tomography (CT). Cone beam computed tomography (CBCT), a new oral and maxillofacial imaging modality that has the capability to produce high-resolution images, has not yet been described for use in evaluating dental disease in rabbits...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28192031/neural-crest-stem-cells-can-differentiate-to-a-cardiomyogenic-lineage-with-an-ability-to-contract-in-response-to-pulsed-infrared-stimulation
#11
Jordan M Greenberg, Vicente Lumbreras, Daniel Pelaez, Suhrud M Rajguru, Herman S Cheung
INTRODUCTION: Cellular cardiomyoplasty has rapidly risen to prominence in the clinic following a myocardial infarction; however, low engraftment of transplanted cells limits the therapeutic benefit to these procedures. Recently, lineage-specific stem cells differentiated into cardiomyocytes have gained much attention to assist in the repair of an injured heart tissue; however, questions regarding the ideal cell source remain. In the present study, we have identified a source that is easy to extract stem cells from and show that the cells present have a high plasticity toward the cardiomyogenic lineage...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28191762/periodontal-tissue-regeneration-using-syngeneic-adipose-derived-stromal-cells-in-a-mouse-model
#12
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28191670/involvement-of-the-phosphoinositide-3-kinase-akt-signaling-pathway-in-bone-morphogenetic-protein-9-stimulated-osteogenic-differentiation-and-stromal-cell-derived-factor-1-production-in-human-periodontal-ligament-fibroblasts
#13
Kirara Furue, Kotaro Sena, Kenji Sakoda, Toshiaki Nakamura, Kazuyuki Noguchi
Recent studies have shown that bone morphogenetic protein 9 (BMP-9) can induce osteogenic differentiation in human periodontal stem cells and human periodontal ligament fibroblasts (PDLFs). Bone morphogenetic protein 9 may be used in periodontal tissue regeneration because of its potent osteoinductive ability. Human periodontal ligament cells also have been demonstrated to produce stromal cell-derived factor 1 (SDF-1), which is important for stem-cell homing and recruitment to injured sites. In the present study, we examined the involvement of the phosphoinositide 3-kinase (PI3K)/Akt signaling axis in osteogenic differentiation and SDF-1 production in human PDLFs stimulated with BMP-9 in osteogenic medium supplemented with dexamethasone and ascorbic acid...
February 13, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28187321/development-and-parameter-identification-of-a-visco-hyperelastic-model-for-the-periodontal-ligament
#14
Huixiang Huang, Wencheng Tang, Qiyan Tan, Bin Yan
The present study developed and implemented a new visco-hyperelastic model that is capable of predicting the time-dependent biomechanical behavior of the periodontal ligament. The constitutive model has been implemented into the finite element package ABAQUS by means of a user-defined material subroutine (UMAT). The stress response is decomposed into two constitutive parts in parallel which are a hyperelastic and a time-dependent viscoelastic stress response. In order to identify the model parameters, the indentation equation based on V-W hyperelastic model and the indentation creep model are developed...
January 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28186709/in-vitro-evaluation-of-the-biological-compatibility-and-antibacterial-activity-of-a-bone-substitute-material-consisting-of-silver-doped-hydroxyapatite-and-bio-oss-%C3%A2
#15
Jingjue Gong, Lei Yang, Qi He, Ting Jiao
This study evaluated biological compatibility and antibacterial activity of a bone substitute material consisting of silver-doped hydroxyapatite (AgHA) and Bio-Oss(®) with different mixture ratios in vitro and investigated its antibacterial mechanism. AgHA was synthesized by a chemical precipitation method. After characterization, AgHA was mixed with Bio-Oss(®) at three ratios: 1:1, 1:2, and 1:4 by weight. Then, Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were used to test the antibacterial activity of the mixture...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28182066/effects-of-alkaline-treatment-for-fibroblastic-adhesion-on-titanium
#16
Miryam Cuellar-Flores, Laura Susana Acosta-Torres, Omar Martínez-Alvarez, Benjamin Sánchez-Trocino, Javier de la Fuente-Hernández, Rigoberto Garcia-Garduño, Rene Garcia-Contreras
BACKGROUND: The surface energy of titanium (Ti) implants is very important when determining hydrophilicity or hydrophobicity, which is vital in osseointegration. The purpose of this study was to determine how Ti plates with an alkaline treatment (NaOH) affect the adhesion and proliferation of human periodontal ligament fibroblasts (HPLF). MATERIALS AND METHODS: In vitro experimental study was carried out. Type 1 commercially pure Ti plates were analyzed with atomic force microscopy to evaluate surface roughness...
November 2016: Dental Research Journal
https://www.readbyqxmd.com/read/28181691/microrna-195-5p-regulates-osteogenic-differentiation-of-periodontal-ligament-cells-under-mechanical-loading
#17
Maolin Chang, Heng Lin, Haidi Fu, Beike Wang, Guangli Han, Mingwen Fan
Osteogenic differentiation and bone formation are tightly regulated by several factors, including microRNAs (miRNAs). However, miRNA expression patterns and function during mechanical loading-induced osteogenic differentiation of human periodontal ligament cells (PDLCs) remain unclear. Here, we investigated the differential expression of miRNA-195-5p in the periodontal tissues of mice under orthodontic mechanical loading and in primary human PDLCs exposed to a simulated tension strain. miR-195-5p was observed to be down-regulated and negatively correlated with osteogenic differentiation...
February 9, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28179939/autogenous-transplantation-for-replacing-a-hopeless-tooth
#18
Mehrsa Zakershahrak, Amirabbas Moshari, Mehdi Vatanpour, Zohreh Khalilak, Afsoon Jalali Ara
Autogenous tooth transplantation (ATT) is a simple and reasonable choice for replacing the missing teeth when a proper donor tooth is available. This report presents a case of successful ATT of a maxillary right third molar for replacement of mandibular right second molar with a concomitant endodontic-periodontal disease. The mandibular second molar was believed to be hopeless due to a severe damage to coronal tooth structure, inappropriate root canal treatment and apical radiolucency. After extraction of mandibular second molar and maxillary third molar (the donor), the tooth was re-implanted into the extracted socket of second molar site...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28179886/does-oxidative-stress-induced-by-alcohol-consumption-affect-orthodontic-treatment-outcome
#19
REVIEW
Jorge M Barcia, Sandra Portolés, Laura Portolés, Alba C Urdaneta, Verónica Ausina, Gema M A Pérez-Pastor, Francisco J Romero, Vincent M Villar
HIGHLIGHTS Ethanol, Periodontal ligament, Extracellular matrix, Orthodontic movement. Alcohol is a legal drug present in several drinks commonly used worldwide (chemically known as ethyl alcohol or ethanol). Alcohol consumption is associated with several disease conditions, ranging from mental disorders to organic alterations. One of the most deleterious effects of ethanol metabolism is related to oxidative stress. This promotes cellular alterations associated with inflammatory processes that eventually lead to cell death or cell cycle arrest, among others...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28177531/recruitment-of-bone-marrow-derived-cells-to-the-periodontal-ligament-via-the-stromal-cell-derived-factor-1-c-x-c-chemokine-receptor-type-4-axis
#20
M Kaku, M Kitami, J M Rosales Rocabado, T Ida, Y Akiba, K Uoshima
BACKGROUND/OBJECTIVES: The periodontal ligament (PDL) is a non-mineralized connective tissue that exists between the alveolar bone and root surface cementum and plays important roles in tooth function. The PDL harbors a remarkable reserve of multipotent stem cells, which maintain various types of cells. However, the sources of these stem cells, other than their developmental origin, are not well understood. MATERIAL AND METHODS: To elucidate the recruitment of bone marrow (BM)-derived stem cells in the PDL, green fluorescent protein (GFP)-expressing BM-derived cells were transplanted into the femoral BM of immunodeficient rats, and the distribution and expression of stem cell markers in the PDL were analyzed in vivo...
February 8, 2017: Journal of Periodontal Research
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